Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in the Registration Statement (FormS-8) pertaining to the 2018 Equity Incentive Plan and 2018 Employee Stock Purchase Plan of Principia Biopharma Inc. of our report dated March 10, 2020, with respect to the consolidated financial statements of Principia Biopharma Inc., included in its Annual Report (Form10-K) for the year ended December 31, 2019, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Redwood City, California
March 10, 2020