| Cover Page | Dec. 14, 2021 | Sep. 29, 2021 |
| Cover [Abstract] | ||
| Document Type | 8-K | |
| Document Period End Date | Dec. 14, 2021 | |
| Entity Registrant Name | SKYE BIOSCIENCE, INC. | |
| Entity Incorporation, State or Country Code | NV | |
| Entity File Number | 000-55136 | |
| Entity Tax Identification Number | 45-0692882 | |
| Entity Address, Address Line One | 11250 El Camino Real | |
| Entity Address, Address Line Two | Suite 100 | |
| Entity Address, City or Town | San Diego | |
| Entity Address, State or Province | CA | |
| Entity Address, Postal Zip Code | 92130 | |
| City Area Code | 858 | |
| Local Phone Number | 410-0266 | |
| Written Communications | false | |
| Soliciting Material | false | |
| Pre-commencement Tender Offer | false | |
| Pre-commencement Issuer Tender Offer | false | |
| Entity Emerging Growth Company | false | |
| Amendment Flag | false | |
| Entity Central Index Key | 0001516551 |
