| Cover Page | Sep. 29, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | Sep. 29, 2022 |
| Entity Registrant Name | SKYE BIOSCIENCE, INC. |
| Entity Incorporation, State or Country Code | NV |
| Entity File Number | 000-55136 |
| Entity Tax Identification Number | 45-0692882 |
| Entity Address, Address Line One | 11250 El Camino Real |
| Entity Address, Address Line Two | Suite 100 |
| Entity Address, City or Town | San Diego |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 92130 |
| City Area Code | 858 |
| Local Phone Number | 410-0266 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
| Amendment Flag | false |
| Entity Central Index Key | 0001516551 |
