Orchid Island Capital (ORC) 10-Q 2021 Q1 Quarterly report

Exhibit 32.1

CERTIFICATION

PURSUANT TO SECTION 906 OF THE

SARBANES-OXLEY ACT OF 2002, 10 U.S.C. SECTION 1350

In connection with the quarterly report on Form 10-Q of Orchid Island Capital,Inc. (the “Company”) for

the period ended March 31, 2021 to be filed with the Securities and ExchangeCommission on or about

the date hereof (the ”Report”), I, Robert E. Cauley, Chairman of the Board and Chief Executive Officer of

the Company, certify,pursuant to Section 906 of the Sarbanes-Oxley Act of 2002,18 U.S.C.

Section 1350, that:

1.

The Report fully complies with the requirements of Section 13(a) or 15(d)of the Securities Exchange

Act of 1934, as amended; and

2.

The information contained in the Report fairly presents, in all materialrespects, the financial

condition and results of operations of the Company at the dates of, andfor the periods covered by, the

Report.

It is not intended that this statement be deemed to be filed for purposes of theSecurities Exchange Act of

1934.

April 30, 2021

/s/ Robert E. Cauley

Robert E. Cauley,

Chairman of the Board and

Chief Executive Officer