Alkermes (ALKS) 10-Q 23 Oct 19 2019 Q3 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	9 Months Ended
	Sep. 30, 2019	Oct. 18, 2019
Cover [Abstract]
Entity Registrant Name	Alkermes plc.
Entity Central Index Key	0001520262
Document Type	10-Q
Document Period End Date	Sep. 30, 2019
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Common Stock, Shares Outstanding		157,522,247
Document Fiscal Year Focus	2019
Document Fiscal Period Focus	Q3
Trading Symbol	ALKS
Entity File Number	001-35299
Entity Incorporation, State or Country Code	L2
Entity Tax Identification Number	98-1007018
Entity Address, Address Line One	Connaught House
Entity Address, Address Line Two	1 Burlington Road
Entity Address, City or Town	Dublin 4
Entity Address, Country	IE
Entity Address, Postal Zip Code	D04 C5Y6
City Area Code	353
Local Phone Number	1-772-8000
Document Quarterly Report	true
Document Transition Report	false
Title of 12(b) Security	Ordinary shares, $0.01 par value
Security Exchange Name	NASDAQ

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
CURRENT ASSETS:
Cash and cash equivalents	$ 261,426	$ 266,762
Investments—short-term	325,756	272,533
Receivables, net	250,234	292,223
Contract assets	5,022	8,230
Inventory	100,987	90,196
Prepaid expenses and other current assets	54,493	53,308
Total current assets	997,918	983,252
PROPERTY, PLANT AND EQUIPMENT, NET	341,406	309,987
INTANGIBLE ASSETS, NET	160,814	191,001
GOODWILL	92,873	92,873
DEFERRED TAX ASSETS	87,615	85,807
CONTINGENT CONSIDERATION	27,400	65,200
INVESTMENTS—LONG-TERM	21,352	80,744
RIGHT-OF-USE ASSETS	13,835
OTHER ASSETS	14,782	16,143
TOTAL ASSETS	1,757,995	1,825,007
CURRENT LIABILITIES:
Accounts payable and accrued expenses	357,126	333,762
Operating lease liabilities—short-term	8,627
Long-term debt—short-term	2,843	2,843
Contract liabilities—short-term	1,798	3,169
Total current liabilities	370,394	339,774
LONG-TERM DEBT	274,838	276,465
CONTRACT LIABILITIES—LONG-TERM	11,188	9,525
OPERATING LEASE LIABILITIES—LONG-TERM	6,657
OTHER LONG-TERM LIABILITIES	26,734	27,958
Total liabilities	689,811	653,722
COMMITMENTS AND CONTINGENT LIABILITIES (Note 14)
SHAREHOLDERS’ EQUITY:
Preferred shares, par value, $0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at September 30, 2019 and December 31, 2018, respectively
Ordinary shares, par value, $0.01 per share; 450,000,000 shares authorized; 160,203,448 and 158,180,833 shares issued; 157,496,990 and 155,757,344 shares outstanding at September 30, 2019 and December 31, 2018, respectively	1,599	1,579
Treasury shares, at cost (2,706,458 and 2,423,489 shares at September 30, 2019 and December 31, 2018, respectively)	(118,300)	(108,969)
Additional paid-in capital	2,563,157	2,467,323
Accumulated other comprehensive loss	(1,638)	(3,280)
Accumulated deficit	(1,376,634)	(1,185,368)
Total shareholders’ equity	1,068,184	1,171,285
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY	$ 1,757,995	$ 1,825,007

CONDENSED CONSOLIDATED BALANC_2

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Sep. 30, 2019	Dec. 31, 2018
Statement Of Financial Position [Abstract]
Preferred stock shares, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock shares, authorized	50,000,000	50,000,000
Preferred stock shares, issued	0	0
Preferred stock shares, outstanding	0	0
Ordinary shares, par value (in dollars per share)	$ 0.01	$ 0.01
Ordinary shares, shares authorized	450,000,000	450,000,000
Ordinary shares, shares issued	160,203,448	158,180,833
Ordinary shares, shares outstanding	157,496,990	155,757,344
Treasury shares	2,706,458	2,423,489

CONDENSED CONSOLIDATED STATEMEN

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
REVENUES:
Total revenues	$ 255,243	$ 248,720	$ 758,217	$ 778,512
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	42,319	39,410	133,903	127,303
Research and development	107,671	101,265	314,676	316,434
Selling, general and administrative	148,701	128,777	444,996	385,181
Amortization of acquired intangible assets	10,173	16,426	30,187	48,742
Total expenses	308,864	285,878	923,762	877,660
OPERATING LOSS	(53,621)	(37,158)	(165,545)	(99,148)
OTHER (EXPENSE) INCOME, NET:
Interest income	3,509	2,561	10,785	5,946
Interest expense	(3,385)	(3,346)	(10,405)	(11,959)
Change in the fair value of contingent consideration	1,300	4,200	(27,800)	(17,300)
Other expense, net	(1,664)	(90)	(1,534)	(2,815)
Total other (expense) income, net	(240)	3,325	(28,954)	(26,128)
LOSS BEFORE INCOME TAXES	(53,861)	(33,833)	(194,499)	(125,276)
INCOME TAX (BENEFIT) PROVISION	(983)	611	(3,233)	4,322
NET LOSS	$ (52,878)	$ (34,444)	$ (191,266)	$ (129,598)
LOSS PER ORDINARY SHARE:
Basic and diluted (in dollars loss per ordinary share)	$ (0.34)	$ (0.22)	$ (1.22)	$ (0.84)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic and diluted (in shares)	157,199	155,328	156,845	154,979
COMPREHENSIVE LOSS:
Net loss	$ (52,878)	$ (34,444)	$ (191,266)	$ (129,598)
Holding gain (loss), net of a tax provision (benefit) of $(15), $95, $479 and $42, respectively	(24)	314	1,642	126
COMPREHENSIVE LOSS	(52,902)	(34,130)	(189,624)	(129,472)
Product sales, net
REVENUES:
Total revenues	138,774	116,035	374,890	317,684
Manufacturing and royalty revenues
REVENUES:
Total revenues	103,783	116,411	340,595	359,253
Research and development revenue
REVENUES:
Total revenues	$ 12,686	$ 16,274	41,732	53,325
License revenue
REVENUES:
Total revenues			$ 1,000	$ 48,250

CONDENSED CONSOLIDATED STATEM_2

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (Parenthetical) - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2019	Sep. 30, 2018
Income Statement [Abstract]
Tax (benefit) provision	$ (15)	$ 265	$ 229	$ 95	$ 47	$ (100)	$ 479	$ 42

CONDENSED CONSOLIDATED STATEM_3

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (191,266)	$ (129,598)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	59,901	77,758
Share-based compensation expense	79,590	76,043
Deferred income taxes	(3,025)	3,879
Change in the fair value of contingent consideration	27,800	17,300
Loss on debt refinancing		2,298
Payment made for debt refinancing		(2,251)
Other non-cash charges	90	1,209
Changes in assets and liabilities:
Receivables	41,988	(17,322)
Contract assets	3,207	(4,366)
Inventory	(10,324)	(2,596)
Prepaid expenses and other assets	2,120	(3,291)
Right-of-use assets	6,306
Accounts payable and accrued expenses	20,542	12,899
Contract liabilities	292	2,485
Operating lease liabilities	(6,845)
Other long-term liabilities	(369)	4,321
Cash flows provided by operating activities	30,007	38,768
CASH FLOWS FROM INVESTING ACTIVITIES:
Additions of property, plant and equipment	(58,972)	(51,841)
Proceeds from the sale of equipment	900	428
Proceeds from contingent consideration	10,000
Purchases of investments	(141,749)	(307,603)
Sales and maturities of investments	149,459	344,624
Cash flows used in investing activities	(40,362)	(14,392)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the issuance of ordinary shares under share-based compensation arrangements	16,381	18,318
Employee taxes paid related to net share settlement of equity awards	(9,230)	(15,785)
Principal payments of long-term debt	(2,132)	(1,421)
Payment made for debt refinancing		(743)
Cash flows provided by financing activities	5,019	369
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS	(5,336)	24,745
CASH AND CASH EQUIVALENTS—Beginning of period	266,762	191,296
CASH AND CASH EQUIVALENTS—End of period	261,426	216,041
Non-cash investing and financing activities:
Purchased capital expenditures included in accounts payable and accrued expenses	$ 14,664	$ 7,117

CONDENSED CONSOLIDATED STATEM_4

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Ordinary Shares	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Treasury Stock
BALANCE at Dec. 31, 2017	$ 1,202,808	$ 1,557	$ 2,338,755	$ (3,792)	$ (1,044,365)	$ (89,347)
BALANCE (in shares) at Dec. 31, 2017		156,057,632				(2,048,176)
Issuance of ordinary shares under employee stock plans	13,165	$ 6	13,159
Issuance of ordinary shares under employee stock plans (in shares)		539,563
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(15,724)	$ 7	(7)			$ (15,724)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		716,123				(261,159)
Share-based compensation expense	20,176		20,176
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	(337)			(337)
Cumulative effect adjustment related to the adoption of new accounting standards	(1,692)				(1,692)
Net loss	(62,505)				(62,505)
BALANCE at Mar. 31, 2018	1,155,891	$ 1,570	2,372,083	(4,129)	(1,108,562)	$ (105,071)
BALANCE (in shares) at Mar. 31, 2018		157,313,318				(2,309,335)
BALANCE at Dec. 31, 2017	1,202,808	$ 1,557	2,338,755	(3,792)	(1,044,365)	$ (89,347)
BALANCE (in shares) at Dec. 31, 2017		156,057,632				(2,048,176)
Net loss	(129,598)
BALANCE at Sep. 30, 2018	1,150,715	$ 1,574	2,433,594	(3,666)	(1,175,655)	$ (105,132)
BALANCE (in shares) at Sep. 30, 2018		157,674,736				(2,310,756)
BALANCE at Mar. 31, 2018	1,155,891	$ 1,570	2,372,083	(4,129)	(1,108,562)	$ (105,071)
BALANCE (in shares) at Mar. 31, 2018		157,313,318				(2,309,335)
Issuance of ordinary shares under employee stock plans	3,835	$ 2	3,833
Issuance of ordinary shares under employee stock plans (in shares)		297,889
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(18)	$ 1	(2)			$ (17)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		1,250				(369)
Share-based compensation expense	30,947		30,947
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	149			149
Net loss	(32,649)				(32,649)
BALANCE at Jun. 30, 2018	1,158,155	$ 1,573	2,406,861	(3,980)	(1,141,211)	$ (105,088)
BALANCE (in shares) at Jun. 30, 2018		157,612,457				(2,309,704)
Issuance of ordinary shares under employee stock plans	1,318	$ 1	1,317
Issuance of ordinary shares under employee stock plans (in shares)		56,945
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(43)		1			$ (44)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		5,334				(1,052)
Share-based compensation expense	25,415		25,415
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	314			314
Net loss	(34,444)				(34,444)
BALANCE at Sep. 30, 2018	1,150,715	$ 1,574	2,433,594	(3,666)	(1,175,655)	$ (105,132)
BALANCE (in shares) at Sep. 30, 2018		157,674,736				(2,310,756)
BALANCE at Dec. 31, 2018	1,171,285	$ 1,579	2,467,323	(3,280)	(1,185,368)	$ (108,969)
BALANCE (in shares) at Dec. 31, 2018		158,180,833				(2,423,489)
Issuance of ordinary shares under employee stock plans	10,554	$ 7	10,547
Issuance of ordinary shares under employee stock plans (in shares)		656,352
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(8,880)	$ 7	93			$ (8,980)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		740,689				(269,357)
Share-based compensation expense	24,810		24,810
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	770			770
Net loss	(96,398)				(96,398)
BALANCE at Mar. 31, 2019	1,102,141	$ 1,593	2,502,773	(2,510)	(1,281,766)	$ (117,949)
BALANCE (in shares) at Mar. 31, 2019		159,577,874				(2,692,846)
BALANCE at Dec. 31, 2018	1,171,285	$ 1,579	2,467,323	(3,280)	(1,185,368)	$ (108,969)
BALANCE (in shares) at Dec. 31, 2018		158,180,833				(2,423,489)
Net loss	(191,266)
BALANCE at Sep. 30, 2019	1,068,184	$ 1,599	2,563,157	(1,638)	(1,376,634)	$ (118,300)
BALANCE (in shares) at Sep. 30, 2019		160,203,448				(2,706,458)
BALANCE at Mar. 31, 2019	1,102,141	$ 1,593	2,502,773	(2,510)	(1,281,766)	$ (117,949)
BALANCE (in shares) at Mar. 31, 2019		159,577,874				(2,692,846)
Issuance of ordinary shares under employee stock plans	2,054	$ 2	2,052
Issuance of ordinary shares under employee stock plans (in shares)		197,953
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(194)					$ (194)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		20,289				(6,397)
Share-based compensation expense	28,261		28,261
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	896			896
Net loss	(41,990)				(41,990)
BALANCE at Jun. 30, 2019	1,091,168	$ 1,595	2,533,086	(1,614)	(1,323,756)	$ (118,143)
BALANCE (in shares) at Jun. 30, 2019		159,796,116				(2,699,243)
Issuance of ordinary shares under employee stock plans	3,773	$ 3	3,770
Issuance of ordinary shares under employee stock plans (in shares)		383,957
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(156)	$ 1				$ (157)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share based awards (in shares)		23,375				(7,215)
Share-based compensation expense	26,301		26,301
Unrealized gain (loss) on marketable securities, net of tax provision (benefit)	(24)			(24)
Net loss	(52,878)				(52,878)
BALANCE at Sep. 30, 2019	$ 1,068,184	$ 1,599	$ 2,563,157	$ (1,638)	$ (1,376,634)	$ (118,300)
BALANCE (in shares) at Sep. 30, 2019		160,203,448				(2,706,458)

CONDENSED CONSOLIDATED STATEM_5

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (Parenthetical) - USD ($) $ in Thousands	3 Months Ended						9 Months Ended
	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Sep. 30, 2019	Sep. 30, 2018
Statement Of Stockholders Equity [Abstract]
Tax (benefit) provision	$ (15)	$ 265	$ 229	$ 95	$ 47	$ (100)	$ 479	$ 42

The Company

The Company	9 Months Ended
	Sep. 30, 2019
Organization Consolidation And Presentation Of Financial Statements [Abstract]
The Company	1. THE COMPANY Alkermes plc is a fully integrated, global biopharmaceutical company that applies its scientific expertise and proprietary technologies to research, develop and commercialize, both with partners and on its own, pharmaceutical products that are designed to address unmet medical needs of patients in major therapeutic areas. The Company has a diversified portfolio of commercial drug products and a clinical pipeline of product candidates focused on CNS disorders such as schizophrenia, depression, addiction and MS, and oncology. Headquartered in Dublin, Ireland, the Company has an R&D center in Waltham, Massachusetts; an R&D and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio.

Summary of Significant Accounti

Summary of Significant Accounting Policies	9 Months Ended
	Sep. 30, 2019
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The accompanying condensed consolidated financial statements of the Company for the three and nine months ended September 30, 2019 and 2018 are unaudited and have been prepared on a basis substantially consistent with the audited financial statements for the year ended December 31, 2018. The year-end condensed consolidated balance sheet data, which is presented for comparative purposes, was derived from audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the U.S. (commonly referred to as “GAAP”). In the opinion of management, the condensed consolidated financial statements include all adjustments, which are of a normal recurring nature, that are necessary to state fairly the results of operations for the reported periods. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto of the Company, which are contained in the Annual Report. The results of the Company’s operations for any interim period are not necessarily indicative of the results of the Company’s operations for any other interim period or for any full fiscal year. Principles of Consolidation The condensed consolidated financial statements include the accounts of Alkermes plc and its wholly-owned subsidiaries as disclosed in Note 2, Summary of Significant Accounting Policies, Use of Estimates The preparation of the Company’s condensed consolidated financial statements in accordance with GAAP requires management to make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, the Company evaluates its estimates, judgments and methodologies, including those related to revenue from contracts with its customers and related allowances, impairment and amortization of intangibles and long-lived assets, share-based compensation, income taxes including the valuation allowance for deferred tax assets, valuation of investments, contingent consideration and litigation. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions. Segment Information The Company operates as one business segment, which is the business of developing, manufacturing and commercializing medicines. The Company’s chief decision maker, the Chairman of the Board and Chief Executive Officer, reviews the Company’s operating results on an aggregate basis and manages the Company’s operations as a single operating unit. Income Taxes The Company’s income tax (benefit) provision primarily relates to U.S. federal and state taxes. The Company records a deferred tax asset or liability based on the difference between the financial statement and tax basis of its assets and liabilities, as measured by enacted jurisdictional tax rates assumed to be in effect when these differences reverse. At September 30, 2019, the Company maintained a valuation allowance against certain of its U.S. and foreign deferred tax assets. The Company evaluates, at each reporting period, the need for a valuation allowance on its deferred tax assets on a jurisdiction-by-jurisdiction basis. New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board (“FASB”) or other standard-setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued guidance that are not yet effective will not have a material impact on its financial position or results of operations upon adoption. Effective January 1, 2019, the Company adopted the requirements under Accounting Standards Update (“ASU”) 2016-02, Leases Leases In June 2016, the FASB issued ASU 2016-13, Measurement of Credit Losses on Financial Instruments In June 2018, the FASB issued ASU 2018-07, Improvements to Nonemployee Share-Based Payment Accounting Compensation – Stock Compensation In August 2018, the FASB issued ASU 2018-14, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement Conceptual Framework for Financial Reporting - Chapter 8: Notes to Financial Statements In August 2018, the FASB issued ASU 2018-15, Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract , which aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license). This ASU also requires the entity to expense the capitalized implementation costs of a hosting arrangement that is a service contract over the term of the hosting arrangement, which includes reasonably certain renewals. This ASU becomes effective for the Company in the year ending December 31, 2020 and early adoption is permitted. The Company has not yet adopted this ASU and is currently assessing the impact that this ASU will have on its consolidated financial statements. In November 2018, the FASB issued ASU 2018-18, Clarifying the Interaction Between Topic 808 and Topic 606

Revenue from Contracts with Cus

Revenue from Contracts with Customers	9 Months Ended
	Sep. 30, 2019
Revenue From Contract With Customer [Abstract]
Revenue from Contracts with Customers	3. REVENUE FROM CONTRACTS WITH CUSTOMERS Under Topic 606, the Company recognizes revenues when its customer obtains control of promised goods or services, in an amount that reflects the consideration the Company expects to receive in exchange for those goods or services. The Company recognizes revenues following the five-step model prescribed under Topic 606: (i) identify contract(s) with a customer; (ii) identify the performance obligation(s) in the contract(s); (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligation(s) in the contract(s); and (v) recognize revenues when (or as) the Company satisfies the performance obligation(s). Product Sales, Net The Company’s product sales, net consist of sales of VIVITROL and ARISTADA (together with ARISTADA INITIO) in the U.S., primarily to wholesalers, specialty distributors and pharmacies. Product sales, net are recognized when the customer obtains control of the product, which is when the product has been received by the customer. During the three and nine months ended September 30, 2019 and 2018, the Company recorded product sales, net, as follows: Three Months Ended September 30, Nine Months Ended September 30, (In thousands) 2019 2018 2019 2018 VIVITROL $ 85,164 $ 79,893 $ 242,546 $ 218,778 ARISTADA 53,610 36,142 132,344 98,906 Total product sales, net $ 138,774 $ 116,035 $ 374,890 $ 317,684 Manufacturing and Royalty Revenues During the three and nine months ended September 30, 2019 and 2018, the Company recorded manufacturing and royalty revenues as follows: Three Months Ended September 30, 2019 Nine Months Ended September 30, 2019 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total INVEGA SUSTENNA/XEPLION & INVEGA TRINZA/TREVICTA $ — $ 68,382 $ 68,382 $ — $ 188,968 $ 188,968 RISPERDAL CONSTA 4,520 3,813 8,333 42,948 12,266 55,214 AMPYRA/FAMPYRA 5,134 2,582 7,716 17,287 12,405 29,692 Other 6,428 12,924 19,352 25,173 41,548 66,721 $ 16,082 $ 87,701 $ 103,783 $ 85,408 $ 255,187 $ 340,595 Three Months Ended September 30, 2018 Nine Months Ended September 30, 2018 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total INVEGA SUSTENNA/XEPLION & INVEGA TRINZA/TREVICTA $ — $ 65,620 $ 65,620 $ — $ 174,956 $ 174,956 RISPERDAL CONSTA 7,267 4,316 11,583 42,296 13,922 56,218 AMPYRA/FAMPYRA 12,894 7,445 20,339 38,000 30,276 68,276 Other 5,036 13,833 18,869 19,420 40,383 59,803 $ 25,197 $ 91,214 $ 116,411 $ 99,716 $ 259,537 $ 359,253 Research and Development Revenue The Company recorded research and development (“R&D”) revenue of $12.1 million and $39.5 million during the three and nine months ended September 30, 2019, respectively, and $15.7 million and $51.0 million during the three and nine months ended September 30, 2018, respectively, related to its license and collaboration agreement with Biogen for diroximel fumarate (“BIIB098”). The Company expects to earn an additional $26.9 million in R&D revenue under this agreement with Biogen through 2021. Contract Assets —Contract assets include unbilled amounts resulting from sales under certain of the Company’s manufacturing contracts where revenue is recognized over time. The products included in the contract assets table below complete the manufacturing process in ten days to eight weeks. Contract assets are classified as current. Contract assets consisted of the following: (In thousands) Contract Assets Contract assets at January 1, 2019 $ 8,230 Additions 24,506 Transferred to receivables, net (27,714 ) Contract assets at September 30, 2019 $ 5,022 Contract Liabilities —Contract liabilities consist of contractual obligations related to deferred revenue. Contract liabilities consisted of the following: (In thousands) Contract Liabilities Contract liabilities at January 1, 2019 $ 12,694 Additions 2,182 Amounts recognized into revenue (1,890 ) Contract liabilities at September 30, 2019 $ 12,986

Investments

Investments	9 Months Ended
	Sep. 30, 2019
Investments Debt And Equity Securities [Abstract]
Investments	4. INVESTMENTS Investments consisted of the following (in thousands): Gross Unrealized Losses Amortized Less than Greater than Estimated September 30, 2019 Cost Gains One Year One Year Fair Value Short-term investments: Available-for-sale securities: Corporate debt securities $ 159,490 $ 775 $ (5 ) $ (7 ) $ 160,253 U.S. government and agency debt securities 99,582 490 (1 ) — 100,071 International government agency debt securities 65,133 306 — (7 ) 65,432 Total short-term investments 324,205 1,571 (6 ) (14 ) 325,756 Long-term investments: Available-for-sale securities: Corporate debt securities 11,017 — (8 ) (30 ) 10,979 U.S. government and agency debt securities 3,497 — (2 ) — 3,495 International government agency debt securities 3,351 — (8 ) — 3,343 17,865 — (18 ) (30 ) $ 17,817 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Fixed term deposit account 1,667 48 — — 1,715 3,487 48 — — 3,535 Total long-term investments 21,352 48 (18 ) (30 ) 21,352 Total investments $ 345,557 $ 1,619 $ (24 ) $ (44 ) $ 347,108 December 31, 2018 Short-term investments: Available-for-sale securities: Corporate debt securities $ 120,197 $ 57 $ (62 ) $ (274 ) $ 119,918 U.S. government and agency debt securities 80,055 115 (11 ) (87 ) 80,072 International government agency debt securities 72,091 85 (8 ) (117 ) 72,051 272,343 257 (81 ) (478 ) 272,041 Held-to-maturity securities: Corporate debt securities 492 — — — 492 Total short-term investments 272,835 257 (81 ) (478 ) 272,533 Long-term investments: Available-for-sale securities: Corporate debt securities 53,505 — (185 ) (93 ) $ 53,227 U.S. government and agency debt securities 18,474 — (21 ) (12 ) 18,441 International government agency debt securities 5,457 — (4 ) — 5,453 77,436 — (210 ) (105 ) 77,121 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Fixed term deposit account 1,667 136 — — 1,803 3,487 136 — — 3,623 Total long-term investments 80,923 136 (210 ) (105 ) 80,744 Total investments $ 353,758 $ 393 $ (291 ) $ (583 ) $ 353,277 The proceeds from the sales and maturities of marketable securities, which were identified using the specific identification method and were primarily reinvested, were as follows: Nine Months Ended September 30, (In thousands) 2019 2018 Proceeds from the sales and maturities of marketable securities $ 149,459 $ 344,624 Realized gains $ — $ 4 Realized losses $ 497 $ 268 The Company’s available-for-sale and held-to-maturity securities at September 30, 2019 had contractual maturities in the following periods: Available-for-sale Held-to-maturity Amortized Estimated Amortized Estimated (In thousands) Cost Fair Value Cost Fair Value Within 1 year $ 232,284 $ 232,939 $ 1,820 $ 1,820 After 1 year through 5 years 109,786 110,634 1,667 1,715 Total $ 342,070 $ 343,573 $ 3,487 $ 3,535 At September 30, 2019, the Company believed that the unrealized losses on its available-for-sale investments were temporary. The investments with unrealized losses consisted primarily of corporate debt securities. In making the determination that the decline in fair value of these securities was temporary, the Company considered various factors, including, but not limited to: the length of time each security was in an unrealized loss position; the extent to which fair value was less than cost; financial condition and near-term prospects of the issuers; the Company’s intent not to sell these securities; and the assessment that it is more likely than not that the Company would not be required to sell these securities before the recovery of their amortized cost basis. In May 2014, the Company entered into an agreement whereby it is committed to provide up to €7.4 million to a partnership, Fountain Healthcare Partners II, L.P. of Ireland (“Fountain”), which was created to carry on the business of investing exclusively in companies and businesses engaged in the healthcare, pharmaceutical and life sciences sectors. As of September 30, 2019, the Company’s total contribution in Fountain was equal to €5.6 million. The Company’s commitment represents approximately 7% of the partnership’s total funding. The Company is accounting for its investment in Fountain under the equity method. During the three and nine months ended September 30, 2019, the Company recorded a decrease in its investment in Fountain of $0.3 million and $0.4 million, respectively. During the three and nine months ended September 30, 2018, the Company recorded an increase in its investment in Fountain of less than $0.1 million and a decrease in its investment in Fountain of $0.4 million, respectively. The changes recorded 5.3

Fair Value Measurements

Fair Value Measurements	9 Months Ended
	Sep. 30, 2019
Fair Value Disclosures [Abstract]
Fair Value Measurements	5. FAIR VALUE MEASUREMENTS The following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value: September 30, (In thousands) 2019 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 25,155 $ 25,155 $ — $ — U.S. government and agency debt securities 103,566 66,573 36,993 — Corporate debt securities 171,232 — 169,279 1,953 International government agency debt securities 68,775 — 68,775 — Contingent consideration 27,400 — — 27,400 Common stock warrants 2,111 — — 2,111 Total $ 398,239 $ 91,728 $ 275,047 $ 31,464 December 31, 2018 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 54,590 $ 54,590 $ — $ — U.S. government and agency debt securities 98,513 60,107 38,406 — Corporate debt securities 173,637 — 173,145 492 International government agency debt securities 77,504 — 77,504 — Contingent consideration 65,200 — — 65,200 Common stock warrants 1,205 — — 1,205 Total $ 470,649 $ 114,697 $ 289,055 $ 66,897 The Company transfers its financial assets and liabilities, measured at fair value on a recurring basis, between the fair value hierarchies at the end of each reporting period. There were no transfers of any securities between the fair value hierarchies during the nine months ended September 30, 2019. The following table is a rollforward of the fair value of the Company’s assets whose fair values were determined using Level 3 inputs at September 30, 2019: (In thousands) Fair Value Balance, January 1, 2019 $ 66,897 Purchase of corporate debt security 1,953 Change in the fair value of contingent consideration (27,800 ) Payments received from contingent consideration (10,000 ) Impairment of corporate debt security (492 ) Increase in the fair value of warrants 906 Balance, September 30, 2019 $ 31,464 The Company’s investments in U.S. government and agency debt securities, international government agency debt securities and corporate debt securities classified as Level 2 within the fair value hierarchy were initially valued at the transaction price and subsequently valued, at the end of each reporting period, utilizing market-observable data. The market-observable data included reportable trades, benchmark yields, credit spreads, broker/dealer quotes, bids, offers, current spot rates and other industry and economic events. The Company validated the prices developed using the market-observable data by obtaining market values from other pricing sources, analyzing pricing data in certain instances and confirming that the relevant markets are active. The Company’s contingent consideration relates to the divestiture of its Gainesville, GA facility in March 2015 (the “Gainesville Transaction”). On December 20, 2018, the Company entered into a Second Amendment to the Purchase and Sale Agreement (“Purchase and Sale Agreement Amendment”) with Recro Pharma, Inc. (“Recro”), pursuant to which the Company received a $5.0 million payment in the first quarter of 2019 and another $5.0 million payment in the second quarter of 2019; the Company is eligible to receive low double-digit royalties on net sales of IV/IM and parenteral forms of Meloxicam and any other product with the same active ingredient as Meloxicam IV/IM that is discovered or identified using certain of the Company’s IP to which Recro was provided a right of use, through license or transfer (the “Meloxicam Product(s)”); and is eligible to receive up to $130.0 million in milestone payments upon the achievement of certain regulatory and sales milestones related to the Meloxicam Products. In accordance with the accounting standard for fair value measurements, the Company’s contingent consideration has been classified as a Level 3 asset as its fair value is based on significant inputs not observable in the market. The fair value of the contingent consideration at September 30, 2019 was determined as follows: • The Company received a $5.0 million payment in the first quarter of 2019 and another $5.0 million payment in the second quarter of 2019; the Company is entitled to receive $5.0 million upon regulatory approval of a New Drug Application (“NDA”) for the first Meloxicam Product; and $45.0 million in seven equal, annual installments beginning on the first anniversary of such approval. The fair value of the regulatory milestone was estimated based on applying the likelihood of achieving the regulatory milestone and applying a discount rate from the expected time the milestone will occur to the balance sheet date. The Company expects the regulatory milestone event to occur in the third quarter of 2020 and used a discount rate of 16.7%; • The Company is entitled to receive future royalties on net sales of Meloxicam Products. To estimate the fair value of the future royalties, the Company assessed the likelihood of a Meloxicam Product being approved for sale and estimated the expected future sales given approval and IP protection. These expected payments were then discounted using a discount rate of 17.0%, which the Company believes captures a market participant’s view of the risk associated with the expected payments; and • The Company is entitled to receive payments of up to $80.0 million upon achieving certain sales milestones on future sales of the Meloxicam Products. The sales milestones were determined through the use of a real options approach, where net sales are simulated in a risk-neutral world. To employ this methodology, the Company used a risk-adjusted expected growth rate based on its assessments of expected growth in net sales of the approved Meloxicam Product, adjusted by an appropriate factor capturing their respective correlation with the market. A resulting expected (probability-weighted) milestone payment was then discounted at a cost of debt of 16.7%. Significant judgment was employed in determining the appropriateness of these assumptions at the acquisition date and for each subsequent period. Accordingly, changes in assumptions described above could have a material impact on the increase or decrease in the fair value of contingent consideration recorded in any given period. In March 2019, Recro received a second complete response letter (“CRL”) from the U.S. Food and Drug Administration (“FDA”) regarding its NDA for IV Meloxicam. As a result of Recro’s receipt of this second CRL, the Company delayed its anticipated date for the FDA’s approval of the IV Meloxicam NDA and reduced the probability of success and amount of forecasted sales due to this delay in our valuation model. At September 30, 2019 and December 31, 2018, the Company determined that the value of the contingent consideration was $27.4 million and $65.2 million, respectively. The Company recorded an increase of $1.3 million and a decrease of $27.8 million during the three and nine months ended September 30, 2019, respectively, and an increase of $4.2 million and a decrease of $17.3 million during the three and nine months ended September 30, 2018, respectively, within “Change in the fair value of contingent consideration” in the accompanying condensed consolidated statements of operations and comprehensive loss. The carrying amounts reflected in the condensed consolidated balance sheets for cash and cash equivalents, accounts receivable, other current assets, accounts payable and accrued expenses approximate fair value due to their short-term nature.

Inventory

Inventory	9 Months Ended
	Sep. 30, 2019
Inventory Disclosure [Abstract]
Inventory	6. INVENTORY Inventory is stated at the lower of cost and net realizable value. Cost is determined using the first-in, first-out method. Inventory consisted of the following: September 30, December 31, (In thousands) 2019 2018 Raw materials $ 34,336 $ 31,824 Work in process 48,315 38,019 Finished goods (1) 18,336 20,353 Total inventory $ 100,987 $ 90,196 (1) At September 30, 2019 and December 31, 2018, the Company had $11.5 million and $11.0 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

Property, Plant and Equipment

Property, Plant and Equipment	9 Months Ended
	Sep. 30, 2019
Property Plant And Equipment [Abstract]
Property, Plant and Equipment	7. PROPERTY, PLANT AND EQUIPMENT Property, plant and equipment consisted of the following: September 30, December 31, (In thousands) 2019 2018 Land $ 6,560 $ 6,486 Building and improvements 173,220 157,053 Furniture, fixtures and equipment 332,886 314,831 Leasehold improvements 20,737 20,105 Construction in progress 114,905 88,983 Subtotal 648,308 587,458 Less: accumulated depreciation (306,902 ) (277,471 ) Total property, plant and equipment, net $ 341,406 $ 309,987

Goodwill and Intangible Assets

Goodwill and Intangible Assets	9 Months Ended
	Sep. 30, 2019
Goodwill And Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets	8. GOODWILL AND INTANGIBLE ASSETS Goodwill and intangible assets consisted of the following: September 30, 2019 December 31, 2018 (In thousands) Weighted Amortizable Life (Years) Gross Carrying Amount Accumulated Amortization Net Carrying Amount Gross Carrying Amount Accumulated Amortization Net Carrying Amount Goodwill $ 92,873 $ — $ 92,873 $ 92,873 $ — $ 92,873 Finite-lived intangible assets: Collaboration agreements 12 $ 465,590 $ (341,214 ) $ 124,376 $ 465,590 $ (319,311 ) $ 146,279 NanoCrystal technology 13 74,600 (44,800 ) 29,800 74,600 (38,942 ) 35,658 OCR (1) 12 42,560 (35,922 ) 6,638 42,560 (33,496 ) 9,064 Total $ 582,750 $ (421,936 ) $ 160,814 $ 582,750 $ (391,749 ) $ 191,001 (1) OCR refers to the Company’s oral control released technologies. Based on the Company’s most recent analysis, amortization of intangible assets included within its condensed consolidated balance sheet at September 30, 2019 is expected to be approximately $40.0 million, $40.0 million, $40.0 million, $35.0 million and $35.0 million in the years ending December 31, 2019 through 2023, respectively. Although the Company believes such available information and assumptions are reasonable, given the inherent risks and uncertainties underlying its expectations regarding such future revenues, there is the potential for the Company’s actual results to vary significantly from such expectations. If revenues are projected to change, the related amortization of the intangible assets will change in proportion to the change in revenues.

Leases

Leases	9 Months Ended
	Sep. 30, 2019
Leases [Abstract]
Leases	9. LEASES The Company adopted Topic 842 on January 1, 2019. Upon adoption, the Company elected the package of transition practical expedients, which allowed it to carry forward prior conclusions related to whether any expired or existing contracts are or contain leases, the lease classification for any expired or existing leases and initial direct costs for existing leases. The Company also elected the practical expedient to not reassess certain land easements and made an accounting policy election to not recognize leases with an initial term of 12 months or less within its condensed consolidated balance sheets and to instead recognize those lease payments on a straight-line basis in its condensed consolidated statements of operations over the lease term. The Company elected to adopt this standard using the optional modified retrospective transition method with no restatement of its prior periods or cumulative adjustment to retained earnings. With the adoption of Topic 842 , the Company’s condensed consolidated balance sheet now contains the following line items: Right-of-use assets, Operating lease liabilities—short-term and Operating lease liabilities—long-term. The Company determined that it held the following significant operating leases of office and laboratory space as of January 1, 2019 : • An operating lease for 175,000 square feet of office and laboratory space in Waltham, Massachusetts that expires in 2021, with an option to extend the term for up to two five-year periods • An operating lease for 67,000 square feet of office space in Waltham, Massachusetts that expires in 2020, with an option to extend the term for up to two one-year periods; • An operating lease for 14,600 square feet of office space in Dublin, Ireland that expires in 2022, with an option to extend the term for an additional five-year period; and • An operating lease for 7,000 square feet of corporate office and administrative space in Washington, D.C. that expires in 2029 and includes an option to extend the term for an additional five-year period The Company also has two additional operating leases that are included in its lease accounting but are not considered significant. As all the existing leases subject to the new lease standard were previously classified as operating leases by the Company, they were similarly classified as operating leases under the new standard. The Company has determined that the identified operating leases did not contain non-lease components and require no further allocation of the total lease cost. Additionally, the agreements in place did not contain information to determine the rate implicit in the leases. As such, the Company calculated the incremental borrowing rate based on the assumed remaining lease term for each lease in order to calculate the present value of the remaining lease payments. At September 30, 2019, the weighted average incremental borrowing rate and the weighted average remaining lease term for the operating leases held by the Company were 4.71% and 4.1 years, respectively. As of September 30, 2019, right-of-use assets and liabilities arising from operating leases were $13.8 million and $15.3 million, respectively. During the three and nine months ended September 30, 2019, cash paid for amounts included for the measurement of lease liabilities was $2.2 million and $6.8 million, respectively and the Company recorded operating lease expense of $2.1 million and $6.3 million, respectively. Future lease payments under non-cancelable leases as of September 30, 2019 and December 31, 2018 consisted of the following: September 30, December 31, (In thousands) 2019 2018 2019 $ 2,219 $ 9,394 2020 8,610 10,717 2021 2,482 4,706 2022 500 2,455 2023 509 2,389 Thereafter 3,101 23,940 Total lease payments $ 17,421 $ 53,601 Less: imputed interest (2,137 ) — Total operating lease liabilities $ 15,284 $ 53,601 In March 2018, the Company entered into a lease agreement for approximately 220,000 square feet of office and laboratory space located in a building that is being built at 900 Winter Street, Waltham, Massachusetts (“900 Winter Street”). The Company plans to occupy the premises in early 2020. The initial term of the lease shall commence on the earlier of: (i) the Delivery Date (defined as the later of (a) January 20, 2020, or (b) the date on which the landlord substantially completes its work in accordance with the terms of the lease), or (ii) the date the Company enters into possession of all or any substantial portion of 900 Winter Street for the conduct of its business (the “Commencement Date”). The initial lease term expires on the last day of the calendar month in which the fifteenth (15 th As the Company (a) does not have the right to obtain or control the leased premises during the construction period ; ( b ) does not have the right of payment for the partially constructed assets and, thus, could be potentially leased to another tenant ; and ( c ) does not legally own or control the land on which the property improvements are being constructed , it was not included as a right-of-use asset at September 3 0 , 2019 . Additionally, the future lease payments, outlined above, included the 900 Winter Street payments as of December 31, 201 8 ; these payments are not included in the table as of September 30, 2019, under Topic 84 2.

Accounts Payable and Accrued Ex

Accounts Payable and Accrued Expenses	9 Months Ended
	Sep. 30, 2019
Payables And Accruals [Abstract]
Accounts Payable and Accrued Expenses	10. ACCOUNTS PAYABLE AND ACCRUED EXPENSES Accounts payable and accrued expenses consisted of the following: September 30, December 31, (In thousands) 2019 2018 Accounts payable $ 81,417 $ 39,767 Accrued compensation 69,191 67,613 Accrued sales discounts, allowances and reserves 130,107 152,911 Accrued other 76,411 73,471 Total accounts payable and accrued expenses $ 357,126 $ 333,762

Long-term Debt

Long-term Debt	9 Months Ended
	Sep. 30, 2019
Debt Disclosure [Abstract]
Long-term Debt	11. LONG-TERM DEBT Long-term debt consisted of the following: September 30, December 31, (In thousands) 2019 2018 2023 Term Loans, due March 26, 2023 $ 277,681 $ 279,308 Less: current portion (2,843 ) (2,843 ) Long-term debt $ 274,838 $ 276,465 In March 2018, the Company amended and refinanced its existing term loan, referred to as Term Loan B-1 (as so amended and refinanced, the “2023 Term Loans”), in order to, among other things, extend the due date of the loan from September 25, 2021 to March 26, 2023, reduce the interest payable from LIBOR plus 2.75% with a LIBOR floor of 0.75% to LIBOR 2.25 0 The Refinancing involved multiple lenders who were considered members of a loan syndicate. In determining whether the Refinancing was to be accounted for as a debt extinguishment or a debt modification, the Company considered whether creditors remained the same or changed and whether the changes in debt terms were substantial. A change in the debt terms was considered to be substantial if the present value of the remaining cash flows under the new terms of the 2023 Term Loans was at least 10% different from the present value of the remaining cash flows under the former Term Loan B-1 (commonly referred to as the “10% Test”). The Company performed a separate 10% Test for each individual creditor participating in the loan syndication. With the exception of one lender, who owned 1% of the total outstanding principal amount of Term Loan B-1 at the date of the Refinancing and was accounted for as a debt extinguishment, the Refinancing was accounted for as a debt modification. The Refinancing resulted in a $2.3 million charge in the three months ended March 31, 2018, which was included in “Interest expense” in the accompanying condensed consolidated statement of operations and comprehensive loss. The estimated fair value of the 2023 Term Loans, which was based on quoted market price indications (Level 2 in the fair value hierarchy, as described in Note 5, Fair Value Measurements

Share-based Compensation

Share-based Compensation	9 Months Ended
	Sep. 30, 2019
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based Compensation	12. SHARE-BASED COMPENSATION Share-based compensation expense consisted of the following: Three Months Ended Nine Months Ended September 30, September 30, (In thousands) 2019 2018 2019 2018 Cost of goods manufactured and sold $ 2,912 $ 2,140 $ 7,395 $ 6,012 Research and development 8,195 7,937 24,076 23,203 Selling, general and administrative 15,622 14,991 48,119 46,828 Total share-based compensation expense $ 26,729 $ 25,068 $ 79,590 $ 76,043 At September 30, 2019 and December 31, 2018, $2.5 million and $2.7 million, respectively, of share-based compensation cost was capitalized and recorded as “Inventory” in the accompanying condensed consolidated balance sheets. In February 2017, the compensation committee of the Company’s board of directors approved awards of restricted stock units (“RSUs”) to all employees employed by the Company during 2017, in each case subject to vesting on the achievement of the following performance criteria: (i) FDA approval of the NDA for ALKS 5461, (ii) the achievement of the pre-specified primary efficacy endpoints in each of two phase 3 studies of ALKS 3831, and (iii) revenues equal to or greater than a pre-specified amount for the year ending December 31, 2019. These performance criteria are being assessed over a performance period of three years from the date of the grant. In December 2018, the Company achieved the pre-specified primary efficacy endpoints on its second of the two phase 3 studies of ALKS 3831, resulting in the vesting of a portion of the performance-based RSUs and the recognition of $17.1 million in share-based compensation expense related to these awards. The Company recognized $2.1 million, $6.7 million and $8.3 million of this expense in cost of goods manufactured and sold; R&D expense; and SG&A expense, respectively. At September 30, 2019, there was $31.6 million of unrecognized compensation cost related to the remaining unvested portion of the performance-based RSUs, which would be recognized in accordance with the terms of the award if and when the Company deems it probable that the performance criteria will be met. The unvested portion of the awards will expire if the performance conditions have not been met on or before the three-year anniversary of the grant date.

Loss Per Share

Loss Per Share	9 Months Ended
	Sep. 30, 2019
Earnings Per Share [Abstract]
Loss Per Share	13. LOSS PER SHARE Basic loss per ordinary share is calculated based upon net loss available to holders of ordinary shares divided by the weighted average number of shares outstanding. For the three and nine months ended September 30, 2019 and 2018, as the Company was in a net loss position, the diluted loss per share calculation did not assume conversion or exercise of stock options and awards as they would have had an anti-dilutive effect on loss per share. The following potential ordinary share equivalents have not been included in the net loss per ordinary share calculation because the effect would have been anti-dilutive: Three Months Ended Nine Months Ended September 30, September 30, (In thousands) 2019 2018 2019 2018 Stock options 13,867 11,553 14,077 10,274 Restricted stock units 3,344 2,678 3,110 2,621 Total 17,211 14,231 17,187 12,895

Commitments and Contingent Liab

Commitments and Contingent Liabilities	9 Months Ended
	Sep. 30, 2019
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingent Liabilities	14. COMMITMENTS AND CONTINGENT LIABILITIES Litigation From time to time, the Company may be subject to legal proceedings and claims in the ordinary course of business. On a quarterly basis, the Company reviews the status of each significant matter and assesses its potential financial exposure. If the potential loss from any claim, asserted or unasserted, or legal proceeding is considered probable and the amount can be reasonably estimated, the Company would accrue a liability for the estimated loss. Because of uncertainties related to claims and litigation, accruals are based on the Company’s best estimates, utilizing all available information. On a periodic basis, as additional information becomes available, or based on specific events such as the outcome of litigation or settlement of claims, the Company may reassess the potential liability related to these matters and may revise these estimates, which could result in material adverse adjustments to the Company’s operating results. At September 30, 2019, there were no potential material losses from claims, asserted or unasserted, or legal proceedings the Company determined were probable of occurring. INVEGA SUSTENNA ANDA Litigation In January 2018 and in August 2019, Janssen Pharmaceuticals NV and Janssen Pharmaceuticals, Inc. initiated patent infringement lawsuits in the United States District Court for the District of New Jersey against Teva entities (Teva Pharmaceuticals USA, Inc.(“Teva”) and Teva Pharmaceuticals Industries, Ltd. (“Teva PI”)) and Mylan entities (Mylan Laboratories Limited (“Mylan Labs”), Mylan Pharmaceuticals Inc. (“Mylan”), and Mylan Institutional LLC), respectively, following filings by each of Teva and Mylan Labs of an abbreviated new drug application (“ANDA”) seeking approval to market a generic version of INVEGA SUSTENNA before the expiration of U.S. Patent No. 9,439,906. Requested judicial remedies in each of the lawsuits included recovery of litigation costs and injunctive relief. The Company is not a party to either of these proceedings. For information about risks relating to the INVEGA SUSTENNA Paragraph IV litigation, see “Part I, Item 1A—Risk Factors” of the Annual Report, including the section entitled “—We or our licensees may face claims against intellectual property rights covering our products and competition from generic drug manufacturers.” AMPYRA ANDA Litigation Eleven separate Paragraph IV Certification Notices had been received by the Company and/or its partner Acorda from: Accord Healthcare, Inc. (“Accord”); Actavis Laboratories FL, Inc. (“Actavis”); Alkem Laboratories Ltd. (“Alkem”); Apotex Corporation and Apotex, Inc. (collectively, “Apotex”); Aurobindo Pharma Ltd. (“Aurobindo”); MicroLabs Limited (“MicroLabs”); Mylan; Par Pharmaceutical, Inc. (“Par”); Roxane Laboratories, Inc. (“Roxane”); Sun Pharmaceutical Industries Limited and Sun Pharmaceuticals Industries Inc. (collectively, “Sun”); and Teva (collectively with Accord, Actavis, Alkem, Apotex, Aurobindo, MicroLabs, Mylan, Par, Roxane and Sun, the “ANDA Filers”) advising that each of the ANDA Filers had submitted an ANDA to the FDA seeking marketing approval for generic versions of AMPYRA (dalfampridine) Extended-Release Tablets, 10 mg. The ANDA Filers challenged the validity of one or more of the Orange Book-listed patents for AMPYRA, and they also asserted that their generic versions do not infringe certain claims of these patents. In response, the Company and/or Acorda filed lawsuits against the ANDA Filers asserting infringement of one or more of the Orange Book-listed patents for AMPYRA. Requested judicial remedies included recovery of litigation costs and injunctive relief. All lawsuits were filed within 45 days from the date of receipt of each of the Paragraph IV Certification Notices from the ANDA Filers. As a result, a 30-month statutory stay of approval period applied to each of the ANDA Filers’ ANDAs under the U.S. Drug Price Competition and Patent Term Restoration Act of 1984 (the “Hatch-Waxman Act”). The first 30-month stay restricted the FDA from approving the ANDA Filers’ ANDAs until July 2017 at the earliest, unless a Federal district court issued a decision adverse to all of the asserted Orange Book-listed patents prior to that date. Lawsuits with eight of the ANDA Filers were consolidated into a single case. The Company and/or Acorda entered into a settlement agreement with each of Accord, Actavis, Alkem, Apotex, Aurobindo, MicroLabs, Par and Sun to resolve the patent litigation that the Company and/or Acorda brought against these settling ANDA Filers. The settlements with these settling ANDA Filers did not impact the patent litigation that the Company and Acorda brought against the remaining ANDA Filers, including as described below. I n M arch 2017, after a bench trial, the U.S. District Court for the District of Delaware (the “Delaware Court ”) issued an opinion (the “Delaware Court Decision”), which, among other things, invalidated U.S. Patent Nos. 8,007,826; 8,354,437; 8,440,703; and 8,663,685 . The Delaware Court also upheld the validity of the U.S. Patent No. 5,540,938 which pertain ed to the formulation of AMPYRA, but that patent expired on July 30, 2018. In May 2017, Acorda filed an appeal with the Federal Circuit of the Delaware Court Decision with respect to the findings on U.S. Patent Nos. 8,007,826; 8,354,437; 8,440,703; and 8,663,685. On September 10, 2018, the Federal Circuit affirmed the Delaware Court Decision, which invalidated U.S. Patent Nos. 8,007,826; 8,354,437; 8,440,703; and 8,663,685 . I n October 2018 , Acorda filed a petition for rehearing and rehearing en banc of the Federal Circuit’s decision . I n January 2019, the Federal Circuit denied Acorda’s petition. I n April 2019 , Acorda filed a petition for writ of certiorari to the Supreme Court of the United States (the “Supreme Court”). On October 7, 2019, the Supreme Court denied Acorda’s petition requesting review of the case , rendering the Federal Circuit decision as final. For information about risks relating to the AMPYRA Paragraph IV litigation and other proceedings see “Part I, Item 1A—Risk Factors” of the Annual Report, including the section entitled “—We or our licensees may face claims against intellectual property rights covering our products and competition from generic drug manufacturers.” VIVITROL IPR Proceeding In April 2018, Amneal Pharmaceuticals LLC (“Amneal”) filed a petition with the Patent Trial and Appeal Board (the “PTAB”) of the U.S. Patent and Trademark Office seeking an inter partes review (“IPR”) of U.S. Patent Number 7,919,499 (the “’499 Patent”), which is an Orange Book-listed patent for VIVITROL, and specifically requesting the cancellation of claims 1-13 of the ’499 Patent. In November 2018, the PTAB instituted an IPR of all of the challenged claims. On July 26, 2019, the Company entered into a settlement and license agreement (the “Settlement Agreement”) with Amneal. Under the terms of the Settlement Agreement, the parties agreed to request termination of the IPR and Alkermes granted Amneal the non-exclusive right to market a generic formulation of VIVITROL in the U.S. beginning sometime in 2028 or earlier under certain circumstances. The PTAB subsequently cancelled the scheduled IPR hearing and terminated the IPR. RISPERDAL CONSTA European Opposition Proceedings In December 2016, Nanjing Luye Pharmaceutical Co., Ltd., Pharmathen SA, Teva PI and Dehns Ltd (a law firm representing an unidentified opponent) filed notices of opposition with the European Patent Office (the “EPO”) in respect of EP 2 269 577 B (the “EP ’577” Patent), which is a patent directed to certain risperidone microsphere compositions, including RISPERDAL CONSTA. Following a hearing on the matter in January 2019, the EPO issued a written decision revoking the EP’577 Patent in April 2019. The Company filed a notice of appeal of the decision to the EPO’s Technical Boards of Appeal on June 12, 2019 and will continue to vigorously defend the EP ’577 Patent. For information about risks relating to the EP ’577 Patent opposition proceedings see “Part I, Item 1A—Risk Factors” of the Annual Report, including the sections entitled “— Patent protection for our products is important and uncertain” and “— Uncertainty over intellectual property in the biopharmaceutical industry has been the source of litigation, which is inherently costly and unpredictable, could significantly delay or prevent approval or commercialization of our products, and could adversely affect our business.” RISPERDAL CONSTA ANDA Litigation On July 17, 2019, the Company, together with Janssen Pharmaceuticals, Inc., initiated a patent infringement lawsuit in the United States District Court for the District of Delaware against Luye Pharma Group Ltd., Luye Pharma (USA) Ltd., Nanjing Luye Pharmaceutical Co., Ltd. and Shandong Luye Pharmaceutical Co., Ltd. (collectively, “Luye”). Luye filed a 505(b)(2) NDA seeking approval to market a competing product to RISPERDAL CONSTA before the expiration of U.S. Patent No. 6,667,061. Requested judicial remedies included, among other things, recovery of litigation costs and injunctive relief. On July 23, 2019, Luye filed its answer and affirmative defenses. For information about risks relating to the RISPERDAL CONSTA Paragraph IV litigation, see “Part I, Item 1A—Risk Factors” of the Annual Report, including the section entitled “—We or our licensees may face claims against intellectual property rights covering our products and competition from generic drug manufacturers.” Government Matters In June 2017 and January 2019, the Company received a subpoena and a civil investigative demand, respectively, each from an Office of the U.S. Attorney for documents related to VIVITROL. The Company is cooperating with the government. Securities Litigation In November 2017, a purported stockholder of the Company filed a putative class action against the Company and certain of its officers (collectively, “Defendants”) in the United States District Court for the Southern District of New York (the “SDNY District Court”) captioned Gagnon v. Alkermes plc, et al., No. 1:17-cv-09178 In December 2018 and January 2019, purported stockholders of the Company filed putative class actions against the Company and certain of its officers in the United States District Court for the Eastern District of New York (the “EDNY District Court”) captioned Karimian v. Alkermes plc, et al., No. 1:18-cv-07410 McDermott v. Alkermes plc, et al., No. 1:19-cv-00624,

Subsequent Events

Subsequent Events	9 Months Ended
	Sep. 30, 2019
Subsequent Events [Abstract]
Subsequent Events	15. SUBSEQUENT EVENTS Following a review of the Company’s operations, cost structure and growth opportunities, on October 18, 2019, the Board of Directors of the Company approved a plan of restructuring, which includes the elimination of approximately 160 current positions across the Company and other cost-saving measures (the “Restructuring”). The Company expects to record a charge in the range of $13.0 million to $15.0 million in the fourth quarter of 2019 as a result of the Restructuring, consisting of one-time termination benefits for employee severance, benefits and related costs, all of which are expected to result in cash expenditures and substantially all of which will be paid out over the next 12 months.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	9 Months Ended
	Sep. 30, 2019
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The accompanying condensed consolidated financial statements of the Company for the three and nine months ended September 30, 2019 and 2018 are unaudited and have been prepared on a basis substantially consistent with the audited financial statements for the year ended December 31, 2018. The year-end condensed consolidated balance sheet data, which is presented for comparative purposes, was derived from audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the U.S. (commonly referred to as “GAAP”). In the opinion of management, the condensed consolidated financial statements include all adjustments, which are of a normal recurring nature, that are necessary to state fairly the results of operations for the reported periods. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto of the Company, which are contained in the Annual Report. The results of the Company’s operations for any interim period are not necessarily indicative of the results of the Company’s operations for any other interim period or for any full fiscal year.
Principles of Consolidation	Principles of Consolidation The condensed consolidated financial statements include the accounts of Alkermes plc and its wholly-owned subsidiaries as disclosed in Note 2, Summary of Significant Accounting Policies,
Use of Estimates	Use of Estimates The preparation of the Company’s condensed consolidated financial statements in accordance with GAAP requires management to make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, the Company evaluates its estimates, judgments and methodologies, including those related to revenue from contracts with its customers and related allowances, impairment and amortization of intangibles and long-lived assets, share-based compensation, income taxes including the valuation allowance for deferred tax assets, valuation of investments, contingent consideration and litigation. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different assumptions or conditions.
Segment Information	Segment Information The Company operates as one business segment, which is the business of developing, manufacturing and commercializing medicines. The Company’s chief decision maker, the Chairman of the Board and Chief Executive Officer, reviews the Company’s operating results on an aggregate basis and manages the Company’s operations as a single operating unit.
Income Taxes	Income Taxes The Company’s income tax (benefit) provision primarily relates to U.S. federal and state taxes. The Company records a deferred tax asset or liability based on the difference between the financial statement and tax basis of its assets and liabilities, as measured by enacted jurisdictional tax rates assumed to be in effect when these differences reverse. At September 30, 2019, the Company maintained a valuation allowance against certain of its U.S. and foreign deferred tax assets. The Company evaluates, at each reporting period, the need for a valuation allowance on its deferred tax assets on a jurisdiction-by-jurisdiction basis.
New Accounting Pronouncements	New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board (“FASB”) or other standard-setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued guidance that are not yet effective will not have a material impact on its financial position or results of operations upon adoption. Effective January 1, 2019, the Company adopted the requirements under Accounting Standards Update (“ASU”) 2016-02, Leases Leases In June 2016, the FASB issued ASU 2016-13, Measurement of Credit Losses on Financial Instruments In June 2018, the FASB issued ASU 2018-07, Improvements to Nonemployee Share-Based Payment Accounting Compensation – Stock Compensation In August 2018, the FASB issued ASU 2018-14, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement Conceptual Framework for Financial Reporting - Chapter 8: Notes to Financial Statements In August 2018, the FASB issued ASU 2018-15, Customer’s Accounting for Implementation Costs Incurred in a Cloud Computing Arrangement That Is a Service Contract , which aligns the requirements for capitalizing implementation costs incurred in a hosting arrangement that is a service contract with the requirements for capitalizing implementation costs incurred to develop or obtain internal-use software (and hosting arrangements that include an internal-use software license). This ASU also requires the entity to expense the capitalized implementation costs of a hosting arrangement that is a service contract over the term of the hosting arrangement, which includes reasonably certain renewals. This ASU becomes effective for the Company in the year ending December 31, 2020 and early adoption is permitted. The Company has not yet adopted this ASU and is currently assessing the impact that this ASU will have on its consolidated financial statements. In November 2018, the FASB issued ASU 2018-18, Clarifying the Interaction Between Topic 808 and Topic 606

Revenue from Contracts with C_2

Revenue from Contracts with Customers (Tables)	9 Months Ended
	Sep. 30, 2019
Schedule of Contract Assets and Contract Liabilities	Contract assets consisted of the following: (In thousands) Contract Assets Contract assets at January 1, 2019 $ 8,230 Additions 24,506 Transferred to receivables, net (27,714 ) Contract assets at September 30, 2019 $ 5,022 Contract liabilities consisted of the following: (In thousands) Contract Liabilities Contract liabilities at January 1, 2019 $ 12,694 Additions 2,182 Amounts recognized into revenue (1,890 ) Contract liabilities at September 30, 2019 $ 12,986
Product sales, net
Schedule of Disaggregation of Revenues	During the three and nine months ended September 30, 2019 and 2018, the Company recorded product sales, net, as follows: Three Months Ended September 30, Nine Months Ended September 30, (In thousands) 2019 2018 2019 2018 VIVITROL $ 85,164 $ 79,893 $ 242,546 $ 218,778 ARISTADA 53,610 36,142 132,344 98,906 Total product sales, net $ 138,774 $ 116,035 $ 374,890 $ 317,684
Manufacturing and royalty revenues
Schedule of Disaggregation of Revenues	During the three and nine months ended September 30, 2019 and 2018, the Company recorded manufacturing and royalty revenues as follows: Three Months Ended September 30, 2019 Nine Months Ended September 30, 2019 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total INVEGA SUSTENNA/XEPLION & INVEGA TRINZA/TREVICTA $ — $ 68,382 $ 68,382 $ — $ 188,968 $ 188,968 RISPERDAL CONSTA 4,520 3,813 8,333 42,948 12,266 55,214 AMPYRA/FAMPYRA 5,134 2,582 7,716 17,287 12,405 29,692 Other 6,428 12,924 19,352 25,173 41,548 66,721 $ 16,082 $ 87,701 $ 103,783 $ 85,408 $ 255,187 $ 340,595 Three Months Ended September 30, 2018 Nine Months Ended September 30, 2018 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total INVEGA SUSTENNA/XEPLION & INVEGA TRINZA/TREVICTA $ — $ 65,620 $ 65,620 $ — $ 174,956 $ 174,956 RISPERDAL CONSTA 7,267 4,316 11,583 42,296 13,922 56,218 AMPYRA/FAMPYRA 12,894 7,445 20,339 38,000 30,276 68,276 Other 5,036 13,833 18,869 19,420 40,383 59,803 $ 25,197 $ 91,214 $ 116,411 $ 99,716 $ 259,537 $ 359,253

Investments (Tables)

Investments (Tables)	9 Months Ended
	Sep. 30, 2019
Investments Debt And Equity Securities [Abstract]
Schedule of Investments	Investments consisted of the following (in thousands): Gross Unrealized Losses Amortized Less than Greater than Estimated September 30, 2019 Cost Gains One Year One Year Fair Value Short-term investments: Available-for-sale securities: Corporate debt securities $ 159,490 $ 775 $ (5 ) $ (7 ) $ 160,253 U.S. government and agency debt securities 99,582 490 (1 ) — 100,071 International government agency debt securities 65,133 306 — (7 ) 65,432 Total short-term investments 324,205 1,571 (6 ) (14 ) 325,756 Long-term investments: Available-for-sale securities: Corporate debt securities 11,017 — (8 ) (30 ) 10,979 U.S. government and agency debt securities 3,497 — (2 ) — 3,495 International government agency debt securities 3,351 — (8 ) — 3,343 17,865 — (18 ) (30 ) $ 17,817 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Fixed term deposit account 1,667 48 — — 1,715 3,487 48 — — 3,535 Total long-term investments 21,352 48 (18 ) (30 ) 21,352 Total investments $ 345,557 $ 1,619 $ (24 ) $ (44 ) $ 347,108 December 31, 2018 Short-term investments: Available-for-sale securities: Corporate debt securities $ 120,197 $ 57 $ (62 ) $ (274 ) $ 119,918 U.S. government and agency debt securities 80,055 115 (11 ) (87 ) 80,072 International government agency debt securities 72,091 85 (8 ) (117 ) 72,051 272,343 257 (81 ) (478 ) 272,041 Held-to-maturity securities: Corporate debt securities 492 — — — 492 Total short-term investments 272,835 257 (81 ) (478 ) 272,533 Long-term investments: Available-for-sale securities: Corporate debt securities 53,505 — (185 ) (93 ) $ 53,227 U.S. government and agency debt securities 18,474 — (21 ) (12 ) 18,441 International government agency debt securities 5,457 — (4 ) — 5,453 77,436 — (210 ) (105 ) 77,121 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Fixed term deposit account 1,667 136 — — 1,803 3,487 136 — — 3,623 Total long-term investments 80,923 136 (210 ) (105 ) 80,744 Total investments $ 353,758 $ 393 $ (291 ) $ (583 ) $ 353,277
Schedule of Proceeds From Sales and Maturities of Marketable Securities Plus the Resulting Realized Gains and Losses	The proceeds from the sales and maturities of marketable securities, which were identified using the specific identification method and were primarily reinvested, were as follows: Nine Months Ended September 30, (In thousands) 2019 2018 Proceeds from the sales and maturities of marketable securities $ 149,459 $ 344,624 Realized gains $ — $ 4 Realized losses $ 497 $ 268
Schedule of Contractual Maturities of Available-for-Sale and Held-to-Maturity Securities	The Company’s available-for-sale and held-to-maturity securities at September 30, 2019 had contractual maturities in the following periods: Available-for-sale Held-to-maturity Amortized Estimated Amortized Estimated (In thousands) Cost Fair Value Cost Fair Value Within 1 year $ 232,284 $ 232,939 $ 1,820 $ 1,820 After 1 year through 5 years 109,786 110,634 1,667 1,715 Total $ 342,070 $ 343,573 $ 3,487 $ 3,535

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	9 Months Ended
	Sep. 30, 2019
Fair Value Disclosures [Abstract]
Summary of the Company's Assets and Liabilities Measured at Fair Value on a Recurring Basis	The following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy of the valuation techniques the Company utilized to determine such fair value: September 30, (In thousands) 2019 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 25,155 $ 25,155 $ — $ — U.S. government and agency debt securities 103,566 66,573 36,993 — Corporate debt securities 171,232 — 169,279 1,953 International government agency debt securities 68,775 — 68,775 — Contingent consideration 27,400 — — 27,400 Common stock warrants 2,111 — — 2,111 Total $ 398,239 $ 91,728 $ 275,047 $ 31,464 December 31, 2018 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 54,590 $ 54,590 $ — $ — U.S. government and agency debt securities 98,513 60,107 38,406 — Corporate debt securities 173,637 — 173,145 492 International government agency debt securities 77,504 — 77,504 — Contingent consideration 65,200 — — 65,200 Common stock warrants 1,205 — — 1,205 Total $ 470,649 $ 114,697 $ 289,055 $ 66,897
Rollforward of the Fair Value of the Assets Determined using Level 3 Inputs	The following table is a rollforward of the fair value of the Company’s assets whose fair values were determined using Level 3 inputs at September 30, 2019: (In thousands) Fair Value Balance, January 1, 2019 $ 66,897 Purchase of corporate debt security 1,953 Change in the fair value of contingent consideration (27,800 ) Payments received from contingent consideration (10,000 ) Impairment of corporate debt security (492 ) Increase in the fair value of warrants 906 Balance, September 30, 2019 $ 31,464

Inventory (Tables)

Inventory (Tables)	9 Months Ended
	Sep. 30, 2019
Inventory Disclosure [Abstract]
Schedule of Inventories	Inventory is stated at the lower of cost and net realizable value. Cost is determined using the first-in, first-out method. Inventory consisted of the following: September 30, December 31, (In thousands) 2019 2018 Raw materials $ 34,336 $ 31,824 Work in process 48,315 38,019 Finished goods (1) 18,336 20,353 Total inventory $ 100,987 $ 90,196 (1) At September 30, 2019 and December 31, 2018, the Company had $11.5 million and $11.0 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

Property, Plant and Equipment (

Property, Plant and Equipment (Tables)	9 Months Ended
	Sep. 30, 2019
Property Plant And Equipment [Abstract]
Schedule of Property, Plant and Equipment	Property, plant and equipment consisted of the following: September 30, December 31, (In thousands) 2019 2018 Land $ 6,560 $ 6,486 Building and improvements 173,220 157,053 Furniture, fixtures and equipment 332,886 314,831 Leasehold improvements 20,737 20,105 Construction in progress 114,905 88,983 Subtotal 648,308 587,458 Less: accumulated depreciation (306,902 ) (277,471 ) Total property, plant and equipment, net $ 341,406 $ 309,987

Goodwill and Intangible Assets

Goodwill and Intangible Assets (Tables)	9 Months Ended
	Sep. 30, 2019
Goodwill And Intangible Assets Disclosure [Abstract]
Schedule of Goodwill and Intangible Assets	Goodwill and intangible assets consisted of the following: September 30, 2019 December 31, 2018 (In thousands) Weighted Amortizable Life (Years) Gross Carrying Amount Accumulated Amortization Net Carrying Amount Gross Carrying Amount Accumulated Amortization Net Carrying Amount Goodwill $ 92,873 $ — $ 92,873 $ 92,873 $ — $ 92,873 Finite-lived intangible assets: Collaboration agreements 12 $ 465,590 $ (341,214 ) $ 124,376 $ 465,590 $ (319,311 ) $ 146,279 NanoCrystal technology 13 74,600 (44,800 ) 29,800 74,600 (38,942 ) 35,658 OCR (1) 12 42,560 (35,922 ) 6,638 42,560 (33,496 ) 9,064 Total $ 582,750 $ (421,936 ) $ 160,814 $ 582,750 $ (391,749 ) $ 191,001 (1) OCR refers to the Company’s oral control released technologies.

Leases (Tables)

Leases (Tables)	9 Months Ended
	Sep. 30, 2019
Leases [Abstract]
Summary of Future Lease Payments Under Non-Cancelable Leases	Future lease payments under non-cancelable leases as of September 30, 2019 and December 31, 2018 consisted of the following: September 30, December 31, (In thousands) 2019 2018 2019 $ 2,219 $ 9,394 2020 8,610 10,717 2021 2,482 4,706 2022 500 2,455 2023 509 2,389 Thereafter 3,101 23,940 Total lease payments $ 17,421 $ 53,601 Less: imputed interest (2,137 ) — Total operating lease liabilities $ 15,284 $ 53,601

Accounts Payable and Accrued _2

Accounts Payable and Accrued Expenses (Tables)	9 Months Ended
	Sep. 30, 2019
Payables And Accruals [Abstract]
Schedule of Accounts Payable and Accrued Expenses	Accounts payable and accrued expenses consisted of the following: September 30, December 31, (In thousands) 2019 2018 Accounts payable $ 81,417 $ 39,767 Accrued compensation 69,191 67,613 Accrued sales discounts, allowances and reserves 130,107 152,911 Accrued other 76,411 73,471 Total accounts payable and accrued expenses $ 357,126 $ 333,762

Long-term Debt (Tables)

Long-term Debt (Tables)	9 Months Ended
	Sep. 30, 2019
Debt Disclosure [Abstract]
Schedule of Long-term Debt	Long-term debt consisted of the following: September 30, December 31, (In thousands) 2019 2018 2023 Term Loans, due March 26, 2023 $ 277,681 $ 279,308 Less: current portion (2,843 ) (2,843 ) Long-term debt $ 274,838 $ 276,465

Share-based Compensation (Table

Share-based Compensation (Tables)	9 Months Ended
	Sep. 30, 2019
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Schedule of Share-based Compensation Expense	Share-based compensation expense consisted of the following: Three Months Ended Nine Months Ended September 30, September 30, (In thousands) 2019 2018 2019 2018 Cost of goods manufactured and sold $ 2,912 $ 2,140 $ 7,395 $ 6,012 Research and development 8,195 7,937 24,076 23,203 Selling, general and administrative 15,622 14,991 48,119 46,828 Total share-based compensation expense $ 26,729 $ 25,068 $ 79,590 $ 76,043

Loss Per Share (Tables)

Loss Per Share (Tables)	9 Months Ended
	Sep. 30, 2019
Earnings Per Share [Abstract]
Schedule of Anti-Dilutive Potential Common Share Equivalents Excluded from Calculation of Net (Loss) Income Per Share	The following potential ordinary share equivalents have not been included in the net loss per ordinary share calculation because the effect would have been anti-dilutive: Three Months Ended Nine Months Ended September 30, September 30, (In thousands) 2019 2018 2019 2018 Stock options 13,867 11,553 14,077 10,274 Restricted stock units 3,344 2,678 3,110 2,621 Total 17,211 14,231 17,187 12,895

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Additional Information (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2019USD ($)segment	Jan. 01, 2019USD ($)	Dec. 31, 2018USD ($)
Accounting Policies [Abstract]
Number of business segments | segment	1
Operating lease, right-of-use asset	$ 13,835	$ 20,100
Operating lease liability	$ 15,284	$ 22,100	$ 53,601

Revenue from Contracts with C_3

Revenue from Contracts with Customers - Schedule of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Disaggregation Of Revenue [Line Items]
Total revenues	$ 255,243	$ 248,720	$ 758,217	$ 778,512
VIVITROL
Disaggregation Of Revenue [Line Items]
Total revenues	85,164	79,893	242,546	218,778
ARISTADA
Disaggregation Of Revenue [Line Items]
Total revenues	53,610	36,142	132,344	98,906
Product sales, net
Disaggregation Of Revenue [Line Items]
Total revenues	$ 138,774	$ 116,035	$ 374,890	$ 317,684

Revenue from Contracts with C_4

Revenue from Contracts with Customers - Schedule of Manufacturing and Royalty Revenues (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Disaggregation Of Revenue [Line Items]
Total revenues	$ 255,243	$ 248,720	$ 758,217	$ 778,512
Manufacturing Revenue
Disaggregation Of Revenue [Line Items]
Total revenues	16,082	25,197	85,408	99,716
Manufacturing Revenue | AMPYRA/ FAMPYRA
Disaggregation Of Revenue [Line Items]
Total revenues	5,134	12,894	17,287	38,000
Manufacturing Revenue | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	4,520	7,267	42,948	42,296
Manufacturing Revenue | Other
Disaggregation Of Revenue [Line Items]
Total revenues	6,428	5,036	25,173	19,420
Royalty Revenue
Disaggregation Of Revenue [Line Items]
Total revenues	87,701	91,214	255,187	259,537
Royalty Revenue | INVEGA SUSTENNA/XEPLION and INVEGA TRINZA/TREVICTA
Disaggregation Of Revenue [Line Items]
Total revenues	68,382	65,620	188,968	174,956
Royalty Revenue | AMPYRA/ FAMPYRA
Disaggregation Of Revenue [Line Items]
Total revenues	2,582	7,445	12,405	30,276
Royalty Revenue | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	3,813	4,316	12,266	13,922
Royalty Revenue | Other
Disaggregation Of Revenue [Line Items]
Total revenues	12,924	13,833	41,548	40,383
Manufacturing and royalty revenues
Disaggregation Of Revenue [Line Items]
Total revenues	103,783	116,411	340,595	359,253
Manufacturing and royalty revenues | INVEGA SUSTENNA/XEPLION and INVEGA TRINZA/TREVICTA
Disaggregation Of Revenue [Line Items]
Total revenues	68,382	65,620	188,968	174,956
Manufacturing and royalty revenues | AMPYRA/ FAMPYRA
Disaggregation Of Revenue [Line Items]
Total revenues	7,716	20,339	29,692	68,276
Manufacturing and royalty revenues | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	8,333	11,583	55,214	56,218
Manufacturing and royalty revenues | Other
Disaggregation Of Revenue [Line Items]
Total revenues	$ 19,352	$ 18,869	$ 66,721	$ 59,803

Revenue from Contracts with C_5

Revenue from Contracts with Customers - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018	Dec. 31, 2021
Disaggregation Of Revenue [Line Items]
Total revenues related to license and collaboration agreement for Diroximel fumarate	$ 255,243	$ 248,720	$ 758,217	$ 778,512
Minimum
Disaggregation Of Revenue [Line Items]
Manufacturing Process period				10 days
Maximum
Disaggregation Of Revenue [Line Items]
Manufacturing Process period				56 days
Biogen
Disaggregation Of Revenue [Line Items]
Total revenues related to license and collaboration agreement for Diroximel fumarate	12,100	15,700	39,500	$ 51,000
Research and development revenue
Disaggregation Of Revenue [Line Items]
Total revenues related to license and collaboration agreement for Diroximel fumarate	$ 12,686	$ 16,274	$ 41,732	$ 53,325
Research and development revenue | Biogen | Forecast
Disaggregation Of Revenue [Line Items]
Additional revenue expected					$ 26,900

Revenue from Contracts with C_6

Revenue from Contracts with Customers - Schedule of Contract Assets and Contract Liabilities (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2019USD ($)
Contract Asset [Abstract]
Contract assets at beginning of period	$ 8,230
Additions	24,506
Transferred to receivables, net	(27,714)
Contract assets at end of period	5,022
Contract Liabilities [Abstract]
Contract liabilities at beginning of the period	12,694
Additions	2,182
Amounts recognized into revenue	(1,890)
Contract liabilities at end of the period	$ 12,986

Investments - Schedule of Inves

Investments - Schedule of Investments (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Available-for-sale securities:
Amortized Cost	$ 342,070
Estimated Fair Value	343,573
Held-to-maturity securities:
Estimated Fair Value	3,535
Long-term Investments
Amortized Cost	21,352	$ 80,923
Gross Unrealized Gains	48	136
Gross Unrealized Losses, Less than One Year	(18)	(210)
Gross Unrealized Losses, Greater than One Year	(30)	(105)
Total long-term investments	21,352	80,744
Total investments
Amortized Cost	345,557	353,758
Gross Unrealized Gains	1,619	393
Gross Unrealized Losses, Less than One Year	(24)	(291)
Gross Unrealized Losses, Greater than One Year	(44)	(583)
Estimated Fair Value	347,108	353,277
Short-term Investments
Amortized Cost		272,835
Gross Unrealized Gains		257
Gross Unrealized Losses, Less than One Year		(81)
Gross Unrealized Losses, Greater than One Year		(478)
Total short-term investments		272,533
Short-term investments
Available-for-sale securities:
Amortized Cost	324,205	272,343
Gross Unrealized Gains	1,571	257
Gross Unrealized Losses, Less than One Year	(6)	(81)
Gross Unrealized Losses, Greater than One Year	(14)	(478)
Estimated Fair Value	325,756	272,041
Short-term investments | Corporate debt securities
Available-for-sale securities:
Amortized Cost	159,490	120,197
Gross Unrealized Gains	775	57
Gross Unrealized Losses, Less than One Year	(5)	(62)
Gross Unrealized Losses, Greater than One Year	(7)	(274)
Estimated Fair Value	160,253	119,918
Held-to-maturity securities:
Amortized Cost		492
Estimated Fair Value		492
Short-term investments | U.S. government and agency debt securities
Available-for-sale securities:
Amortized Cost	99,582	80,055
Gross Unrealized Gains	490	115
Gross Unrealized Losses, Less than One Year	(1)	(11)
Gross Unrealized Losses, Greater than One Year		(87)
Estimated Fair Value	100,071	80,072
Short-term investments | International government agency debt securities
Available-for-sale securities:
Amortized Cost	65,133	72,091
Gross Unrealized Gains	306	85
Gross Unrealized Losses, Less than One Year		(8)
Gross Unrealized Losses, Greater than One Year	(7)	(117)
Estimated Fair Value	65,432	72,051
Long-term investments
Available-for-sale securities:
Amortized Cost	17,865	77,436
Gross Unrealized Losses, Less than One Year	(18)	(210)
Gross Unrealized Losses, Greater than One Year	(30)	(105)
Estimated Fair Value	17,817	77,121
Held-to-maturity securities:
Amortized Cost	3,487	3,487
Gross Unrealized Gains	48	136
Estimated Fair Value	3,535	3,623
Long-term investments | Certificates of deposit
Held-to-maturity securities:
Amortized Cost	1,820	1,820
Estimated Fair Value	1,820	1,820
Long-term investments | Corporate debt securities
Available-for-sale securities:
Amortized Cost	11,017	53,505
Gross Unrealized Losses, Less than One Year	(8)	(185)
Gross Unrealized Losses, Greater than One Year	(30)	(93)
Estimated Fair Value	10,979	53,227
Long-term investments | U.S. government and agency debt securities
Available-for-sale securities:
Amortized Cost	3,497	18,474
Gross Unrealized Losses, Less than One Year	(2)	(21)
Gross Unrealized Losses, Greater than One Year		(12)
Estimated Fair Value	3,495	18,441
Long-term investments | International government agency debt securities
Available-for-sale securities:
Amortized Cost	3,351	5,457
Gross Unrealized Losses, Less than One Year	(8)	(4)
Estimated Fair Value	3,343	5,453
Long-term investments | Fixed Term Deposit Account
Held-to-maturity securities:
Amortized Cost	1,667	1,667
Gross Unrealized Gains	48	136
Estimated Fair Value	$ 1,715	$ 1,803

Investments - Schedule of Proce

Investments - Schedule of Proceeds From Sales and Maturities of Marketable Securities Plus the Resulting Realized Gains and Losses (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018
Investments Debt And Equity Securities [Abstract]
Proceeds from the sales and maturities of marketable securities	$ 149,459	$ 344,624
Realized gains		4
Realized losses	$ 497	$ 268

Investments - Schedule of Contr

Investments - Schedule of Contractual Maturities of Available-for-Sale and Held-to-Maturity Securities (Details) $ in Thousands	Sep. 30, 2019USD ($)
Available-for-sale, Amortized Cost
Within 1 year	$ 232,284
After 1 year through 5 years	109,786
Amortized Cost	342,070
Available-for-sale, Estimated Fair Value
Within 1 year	232,939
After 1 year through 5 years	110,634
Total	343,573
Held-to-maturity, Amortized Cost
Within 1 year	1,820
After 1 year through 5 years	1,667
Total	3,487
Held-to-maturity, Estimated Fair Value
Within 1 year	1,820
After 1 year through 5 years	1,715
Total	$ 3,535

Investments - Additional Inform

Investments - Additional Information (Details) - Fountain Healthcare Partners II, LP of Ireland $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2019USD ($)	Sep. 30, 2018USD ($)	Sep. 30, 2019USD ($)	Sep. 30, 2018USD ($)	Sep. 30, 2019EUR (€)	Dec. 31, 2018USD ($)	May 31, 2014EUR (€)
Equity method investment
Funding commitment as percentage of partnership's total funding	7.00%		7.00%		7.00%
Increase (decrease) in carrying value of investment of the entity, which represents the Company's share of investee's net gains (losses)	$ (0.3)		$ (0.4)	$ (0.4)
Maximum
Equity method investment
Maximum commitment on equity method investment | €							€ 7,400,000
Increase (decrease) in carrying value of investment of the entity, which represents the Company's share of investee's net gains (losses)		$ 0.1
Other Assets
Equity method investment
Total equity method commitment | €					€ 5,600,000
Carrying value of equity investment	$ 5.3		$ 5.3			$ 5.5

Fair Value Measurements - Summa

Fair Value Measurements - Summary of the Company's Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Fair value
Debt securities	$ 343,573
Contingent consideration	27,400	$ 65,200
Recurring Basis
Fair value
Cash equivalents	25,155	54,590
Contingent consideration	27,400	65,200
Common stock warrants	2,111	1,205
Assets, Total	398,239	470,649
Recurring Basis | Level 1
Fair value
Cash equivalents	25,155	54,590
Assets, Total	91,728	114,697
Recurring Basis | Level 2
Fair value
Assets, Total	275,047	289,055
Recurring Basis | Level 3
Fair value
Contingent consideration	27,400	65,200
Common stock warrants	2,111	1,205
Assets, Total	31,464	66,897
U.S. government and agency debt securities | Recurring Basis
Fair value
Debt securities	103,566	98,513
U.S. government and agency debt securities | Recurring Basis | Level 1
Fair value
Debt securities	66,573	60,107
U.S. government and agency debt securities | Recurring Basis | Level 2
Fair value
Debt securities	36,993	38,406
Corporate debt securities | Recurring Basis
Fair value
Debt securities	171,232	173,637
Corporate debt securities | Recurring Basis | Level 2
Fair value
Debt securities	169,279	173,145
Corporate debt securities | Recurring Basis | Level 3
Fair value
Debt securities	1,953	492
International government agency debt securities | Recurring Basis
Fair value
Debt securities	68,775	77,504
International government agency debt securities | Recurring Basis | Level 2
Fair value
Debt securities	$ 68,775	$ 77,504

Fair Value Measurements - Addit

Fair Value Measurements - Additional Information (Details)	3 Months Ended				9 Months Ended
	Sep. 30, 2019USD ($)itemMilestone	Jun. 30, 2019USD ($)	Mar. 31, 2019USD ($)	Sep. 30, 2018USD ($)	Sep. 30, 2019USD ($)itemMilestone	Sep. 30, 2018USD ($)	Sep. 30, 2020item	Dec. 31, 2018USD ($)
Fair Value
Transfers between the levels					$ 0
Contingent consideration	$ 27,400,000				27,400,000			$ 65,200,000
Increase (decrease) in the fair value of contingent consideration	$ 1,300,000			$ 4,200,000	$ (27,800,000)	$ (17,300,000)
Discount Rate | Real options approach
Fair Value
Discount rate (as a percent) | item	16.7				16.7
Discount Rate | Future royalties
Fair Value
Discount rate (as a percent) | item	17				17
Recro
Fair Value
Milestone payments received		$ 5,000,000	$ 5,000,000
Milestone payments receivable upon achievement of certain regulatory and sales milestones					$ 130,000,000
Milestone payment upon regulatory approval of New Drug Application					5,000,000
Milestone annual payable	$ 45,000,000				$ 45,000,000
Number of milestone payment upon approval of New Drug Application | Milestone	7				7
Recro | Maximum
Fair Value
Milestone payments receivable					$ 80,000,000
Recro | Discount Rate | Forecast
Fair Value
Discount rate (as a percent) | item							16.7

Fair Value Measurements - Rollf

Fair Value Measurements - Rollforward of the Fair Value of the Assets Determined using Level 3 Inputs (Details) $ in Thousands	9 Months Ended
	Sep. 30, 2019USD ($)
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Balance at the beginning of the period	$ 66,897
Payments received from contingent consideration	(10,000)
Impairment of corporate debt security	(492)
Balance at the end of the period	31,464
Corporate Debt Security
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Purchase of corporate debt security	1,953
Change In The Fair Value Of Contingent Consideration
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Change in the fair value	(27,800)
Warrants
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Change in the fair value	$ 906

Inventory - Schedule of Invento

Inventory - Schedule of Inventories (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Inventory Disclosure [Abstract]
Raw materials	$ 34,336	$ 31,824
Work in process	48,315	38,019
Finished goods	18,336	20,353
Total inventory	$ 100,987	$ 90,196

Inventory - Schedule of Inven_2

Inventory - Schedule of Inventories (Parenthetical) (Details) - USD ($) $ in Millions	Sep. 30, 2019	Dec. 31, 2018
Inventory Disclosure [Abstract]
Finished goods inventory located at third-party warehouse and shipping service provider	$ 11.5	$ 11

Property, Plant and Equipment -

Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Property, plant and equipment
Property, plant and equipment, gross	$ 648,308	$ 587,458
Less: accumulated depreciation	(306,902)	(277,471)
Total property, plant and equipment, net	341,406	309,987
Land
Property, plant and equipment
Property, plant and equipment, gross	6,560	6,486
Building and Improvements
Property, plant and equipment
Property, plant and equipment, gross	173,220	157,053
Furniture, Fixtures and Equipment
Property, plant and equipment
Property, plant and equipment, gross	332,886	314,831
Leasehold Improvements
Property, plant and equipment
Property, plant and equipment, gross	20,737	20,105
Construction in Progress
Property, plant and equipment
Property, plant and equipment, gross	$ 114,905	$ 88,983

Goodwill and Intangible Asset_2

Goodwill and Intangible Assets - Schedule of Goodwill and Intangible Assets (Details) - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2019	Dec. 31, 2018
Goodwill
Gross Carrying Amount	$ 92,873	$ 92,873
Net Carrying Amount	92,873	92,873
Finite-lived intangible assets:
Gross Carrying Amount	582,750	582,750
Accumulated Amortization	(421,936)	(391,749)
Net Carrying Amount	$ 160,814	191,001
Collaboration agreements
Finite-lived intangible assets:
Weighted Amortizable Life	12 years
Gross Carrying Amount	$ 465,590	465,590
Accumulated Amortization	(341,214)	(319,311)
Net Carrying Amount	$ 124,376	146,279
NanoCrystal technology
Finite-lived intangible assets:
Weighted Amortizable Life	13 years
Gross Carrying Amount	$ 74,600	74,600
Accumulated Amortization	(44,800)	(38,942)
Net Carrying Amount	$ 29,800	35,658
OCR technologies
Finite-lived intangible assets:
Weighted Amortizable Life	12 years
Gross Carrying Amount	$ 42,560	42,560
Accumulated Amortization	(35,922)	(33,496)
Net Carrying Amount	$ 6,638	$ 9,064

Goodwill and Intangible Asset_3

Goodwill and Intangible Assets - Additional Information (Details) $ in Millions	Sep. 30, 2019USD ($)
Expected amortization of intangible assets
2019	$ 40
2020	40
2021	40
2022	35
2023	$ 35

Leases - Additional Information

Leases - Additional Information (Details) $ in Thousands	Jan. 01, 2019USD ($)ft²Option	Mar. 31, 2018ft²	Sep. 30, 2019USD ($)	Sep. 30, 2019USD ($)lease	Dec. 31, 2018USD ($)
Lessee Lease Description [Line Items]
Area of real estate property		220,000
Lessee operating lease term of option to extend		10 years
Operating lease, existence of option to extend		true
Number of additional operating leases | lease				2
Weighted average incremental borrowing rate			4.71%	4.71%
Weighted average remaining lease term			4 years 1 month 6 days	4 years 1 month 6 days
Right-of-use assets | $	$ 20,100		$ 13,835	$ 13,835
Operating lease liability | $	$ 22,100		15,284	15,284	$ 53,601
Payments for operating leases | $			2,200	6,800
Operating lease expense | $			$ 2,100	$ 6,300
MASSACHUSETTS | Corporate office and administrative space expire in 2021
Lessee Lease Description [Line Items]
Area of real estate property	175,000
Maximum number of option to extend lease term | Option	2
Lessee operating lease term of option to extend	5 years
Operating lease, existence of option to extend	true
MASSACHUSETTS | Corporate office and administrative space expire in 2020
Lessee Lease Description [Line Items]
Area of real estate property	67,000
Maximum number of option to extend lease term | Option	2
Lessee operating lease term of option to extend	1 year
Operating lease, existence of option to extend	true
Ireland | Corporate office and administrative space expire in 2022
Lessee Lease Description [Line Items]
Area of real estate property	14,600
Lessee operating lease term of option to extend	5 years
Operating lease, existence of option to extend	true
Washington | Corporate office and administrative space expire In 2029
Lessee Lease Description [Line Items]
Area of real estate property	7,000
Lessee operating lease term of option to extend	5 years
Operating lease, existence of option to extend	true

Leases - Summary of Future Leas

Leases - Summary of Future Lease Payments Under Non-Cancelable Leases (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Jan. 01, 2019	Dec. 31, 2018
Leases [Abstract]
2019	$ 2,219
2020	8,610
2021	2,482
2022	500
2023	509
Thereafter	3,101
Total lease payments	17,421
Less: imputed interest	(2,137)
Total operating lease liabilities	$ 15,284	$ 22,100	$ 53,601
2019			9,394
2020			10,717
2021			4,706
2022			2,455
2023			2,389
Thereafter			23,940
Total lease payments			$ 53,601

Accounts Payable and Accrued _3

Accounts Payable and Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Payables And Accruals [Abstract]
Accounts payable	$ 81,417	$ 39,767
Accrued compensation	69,191	67,613
Accrued sales discounts, allowances and reserves	130,107	152,911
Accrued other	76,411	73,471
Total accounts payable and accrued expenses	$ 357,126	$ 333,762

Long-term Debt - Schedule of Lo

Long-term Debt - Schedule of Long-term Debt (Details) - USD ($) $ in Thousands	Sep. 30, 2019	Dec. 31, 2018
Long-term debt
Less: current portion	$ (2,843)	$ (2,843)
Long-term debt	274,838	276,465
2023 Term Loans
Long-term debt
2023 Term Loans, due March 26, 2023	277,681	279,308
Less: current portion	(2,843)	(2,843)
Long-term debt	$ 274,838	$ 276,465

Long-term Debt - Additional Inf

Long-term Debt - Additional Information (Details) $ in Millions	Oct. 12, 2016	Mar. 31, 2019Lender	Mar. 31, 2018USD ($)	Sep. 30, 2019USD ($)	Mar. 31, 2019	Dec. 31, 2018USD ($)
Long-term debt
Number of lender holding percentage of outstanding amount | Lender		1
Percentage of outstanding principal amount held by lender		1.00%
Level 2
Long-term debt
Amount to be realized in the future				$ 273.3		$ 274.7
Interest Expense
Long-term debt
Refinancing charges			$ 2.3
Minimum
Long-term debt
Threshold percentage comparing present value of remaining cash flows		10.00%
Term Loan B-1
Long-term debt
Due date of loan	Sep. 25, 2021
Term Loan B-1 | LIBOR
Long-term debt
Interest rate added to base rate (as a percent)	2.75%
Interest rate, variable interest rate floor (as a percent)	0.75%
2023 Term Loans
Long-term debt
Due date of loan					Mar. 26, 2023
Variable interest rate base				LIBOR
2023 Term Loans | LIBOR
Long-term debt
Interest rate added to base rate (as a percent)					2.25%
Interest rate, variable interest rate floor (as a percent)					0.00%

Share-based Compensation - Sche

Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Share-based compensation Expense
Total share-based compensation expense	$ 26,729	$ 25,068	$ 79,590	$ 76,043
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	2,912	2,140	7,395	6,012
Research and development
Share-based compensation Expense
Total share-based compensation expense	8,195	7,937	24,076	23,203
Selling, General and Administrative
Share-based compensation Expense
Total share-based compensation expense	$ 15,622	$ 14,991	$ 48,119	$ 46,828

Share-based Compensation - Addi

Share-based Compensation - Additional Information (Details) $ in Thousands	1 Months Ended	3 Months Ended		9 Months Ended		12 Months Ended
	Dec. 31, 2018USD ($)	Sep. 30, 2019USD ($)	Sep. 30, 2018USD ($)	Sep. 30, 2019USD ($)item	Sep. 30, 2018USD ($)	Dec. 31, 2018USD ($)
Share-based compensation Expense
Share-based compensation expense		$ 26,729	$ 25,068	$ 79,590	$ 76,043
Cost of goods manufactured and sold
Share-based compensation Expense
Share-based compensation expense		2,912	2,140	7,395	6,012
Research and development
Share-based compensation Expense
Share-based compensation expense		8,195	7,937	24,076	23,203
Selling, General and Administrative
Share-based compensation Expense
Share-based compensation expense		15,622	$ 14,991	$ 48,119	$ 46,828
Performance-based RSUs
Share-based compensation Expense
Number of Phase 3 studies of ALKS 3831 | item				2
Number of years from the date of the grant				3 years
Unrecognized compensation cost		$ 31,600		$ 31,600
Expiration period				3 years
Share-based compensation expense	$ 17,100
Performance-based RSUs | Cost of goods manufactured and sold
Share-based compensation Expense
Share-based compensation expense	2,100
Performance-based RSUs | Research and development
Share-based compensation Expense
Share-based compensation expense	6,700
Performance-based RSUs | Selling, General and Administrative
Share-based compensation Expense
Share-based compensation expense	$ 8,300
Inventory
Share-based compensation Expense
Share based compensation cost capitalized				$ 2,500		$ 2,700

Loss Per Share - Schedule of An

Loss Per Share - Schedule of Anti-Dilutive Potential Common Share Equivalents Excluded from Calculation of Net (Loss) Income Per Share (Details) - shares shares in Thousands	3 Months Ended		9 Months Ended
	Sep. 30, 2019	Sep. 30, 2018	Sep. 30, 2019	Sep. 30, 2018
Denominator:
Anti-dilutive potential common equivalent shares excluded from calculation of net loss per ordinary share	17,211	14,231	17,187	12,895
Stock Options
Denominator:
Anti-dilutive potential common equivalent shares excluded from calculation of net loss per ordinary share	13,867	11,553	14,077	10,274
Restricted Stock Units
Denominator:
Anti-dilutive potential common equivalent shares excluded from calculation of net loss per ordinary share	3,344	2,678	3,110	2,621

Commitments and Contingent Li_2

Commitments and Contingent Liabilities - Additional Information (Details)	9 Months Ended
	Sep. 30, 2019USD ($)NoticeFiler
Commitments And Contingencies [Line Items]
Potential losses from claims, legal proceedings probable of occurring | $	$ 0
Number of separate Paragraph IV notices received | Notice	11
Maximum number of days for lawsuit	45 days
Minimum number of months before FDA can approve patent request	30 months
Number of ANDA Filers consolidated to a single case | Filer	8
Loss contingency lead plaintiff filing date	April 2019
Loss contingency denied date	Jul. 2, 2019
Amneal
Commitments And Contingencies [Line Items]
Settlement agreement entered date	Jul. 26, 2019

Subsequent Events - Additional

Subsequent Events - Additional Information (Details) - Subsequent Events $ in Millions	Oct. 18, 2019USD ($)Position
Subsequent Event [Line Items]
Restructuring and related activities, initiation date	Oct. 18, 2019
Expected number of positions eliminated | Position	160
Restructuring and related activities description	The Company expects to record a charge in the range of $13.0 million to $15.0 million in the fourth quarter of 2019 as a result of the Restructuring, consisting of one-time termination benefits for employee severance, benefits and related costs, all of which are expected to result in cash expenditures and substantially all of which will be paid out over the next 12 months
Minimum
Subsequent Event [Line Items]
Restructuring and related expected charges	$ 13
Maximum
Subsequent Event [Line Items]
Restructuring and related expected charges	$ 15