Alkermes (ALKS) 10-Q 27 Jul 22 2022 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2022	Jul. 22, 2022
Cover [Abstract]
Entity Registrant Name	Alkermes plc.
Entity Central Index Key	0001520262
Document Type	10-Q
Document Period End Date	Jun. 30, 2022
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Large Accelerated Filer
Entity Common Stock, Shares Outstanding		164,254,275
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Trading Symbol	ALKS
Entity File Number	001-35299
Entity Incorporation, State or Country Code	L2
Entity Tax Identification Number	98-1007018
Entity Address, Address Line One	Connaught House
Entity Address, Address Line Two	1 Burlington Road
Entity Address, City or Town	Dublin 4
Entity Address, Country	IE
Entity Address, Postal Zip Code	D04 C5Y6
City Area Code	353
Local Phone Number	1-772-8000
Document Quarterly Report	true
Document Transition Report	false
Title of 12(b) Security	Ordinary shares, $0.01 par value
Security Exchange Name	NASDAQ

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
CURRENT ASSETS:
Cash and cash equivalents	$ 254,646	$ 337,544
Receivables, net	245,840	313,193
Investments—short-term	326,321	198,767
Inventory	155,608	150,335
Contract assets	16,486	13,363
Prepaid expenses and other current assets	47,090	48,967
Total current assets	1,045,991	1,062,169
PROPERTY, PLANT AND EQUIPMENT, NET	337,146	341,054
INVESTMENTS—LONG-TERM	179,010	229,430
RIGHT-OF-USE ASSETS	111,119	115,627
INTANGIBLE ASSETS, NET	56,011	74,043
GOODWILL	92,873	92,873
DEFERRED TAX ASSETS	123,702	81,833
OTHER ASSETS	11,565	27,455
TOTAL ASSETS	1,957,417	2,024,484
CURRENT LIABILITIES:
Accounts payable and accrued expenses	186,814	208,491
Accrued sales discounts, allowances and reserves	228,973	237,216
Operating lease liabilities—short-term	15,944	16,240
Contract liabilities—short-term	3,787	6,339
Current portion of long-term debt	3,000	3,000
Total current liabilities	438,518	471,286
LONG-TERM DEBT	291,537	292,804
OPERATING LEASE LIABILITIES—LONG-TERM	99,832	104,162
OTHER LONG-TERM LIABILITIES	45,206	43,648
Total liabilities	875,093	911,900
COMMITMENTS AND CONTINGENT LIABILITIES (Note 15)
SHAREHOLDERS’ EQUITY:
Preferred shares, par value, $0.01 per share; 50,000,000 shares authorized; zero issued and outstanding at June 30, 2022 and December 31, 2021, respectively
Ordinary shares, par value, $0.01 per share; 450,000,000 shares authorized; 168,782,701 and 165,790,549 shares issued; 164,232,704 and 161,937,327 shares outstanding at June 30, 2022 and December 31, 2021, respectively	1,688	1,658
Treasury shares, at cost (4,549,997 and 3,853,222 shares at June 30, 2022 and December 31, 2021, respectively)	(160,241)	(142,658)
Additional paid-in capital	2,858,422	2,798,325
Accumulated other comprehensive loss	(10,488)	(3,723)
Accumulated deficit	(1,607,057)	(1,541,018)
Total shareholders’ equity	1,082,324	1,112,584
TOTAL LIABILITIES AND SHAREHOLDERS’ EQUITY	$ 1,957,417	$ 2,024,484

CONDENSED CONSOLIDATED BALANC_2

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) (unaudited) - $ / shares	Jun. 30, 2022	Dec. 31, 2021
Statement Of Financial Position [Abstract]
Preferred stock shares, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock shares, authorized	50,000,000	50,000,000
Preferred stock shares, issued	0	0
Preferred stock shares, outstanding	0	0
Ordinary shares, par value (in dollars per share)	$ 0.01	$ 0.01
Ordinary shares, shares authorized	450,000,000	450,000,000
Ordinary shares, shares issued	168,782,701	165,790,549
Ordinary shares, shares outstanding	164,232,704	161,937,327
Treasury shares	4,549,997	3,853,222

CONDENSED CONSOLIDATED STATEMEN

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE (LOSS) INCOME (unaudited) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
REVENUES:
Total revenues	$ 276,219	$ 303,717	$ 554,764	$ 555,147
EXPENSES:
Cost of goods manufactured and sold (exclusive of amortization of acquired intangible assets shown below)	58,360	53,124	113,519	94,144
Research and development	92,873	97,473	188,826	189,741
Selling, general and administrative	150,377	139,188	295,429	264,356
Amortization of acquired intangible assets	9,066	9,511	18,032	18,917
Total expenses	310,676	299,296	615,806	567,158
OPERATING (LOSS) INCOME	(34,457)	4,421	(61,042)	(12,011)
OTHER (EXPENSE) INCOME, NET:
Interest income	896	623	1,469	1,487
Interest expense	(2,369)	(2,407)	(4,719)	(6,377)
Change in the fair value of contingent consideration	870	3,240	(18,197)	4,518
Other income (expense), net	1,810	(222)	4,241	(615)
Total other (expense) income, net	1,207	1,234	(17,206)	(987)
(LOSS) EARNINGS BEFORE INCOME TAXES	(33,250)	5,655	(78,248)	(12,998)
INCOME TAX (BENEFIT) PROVISION	(3,114)	3,291	(12,209)	7,056
NET (LOSS) INCOME	$ (30,136)	$ 2,364	$ (66,039)	$ (20,054)
(LOSS) EARNINGS PER ORDINARY SHARE:
Basic	$ (0.18)	$ 0.01	$ (0.40)	$ (0.13)
Diluted	$ (0.18)	$ 0.01	$ (0.40)	$ (0.13)
WEIGHTED AVERAGE NUMBER OF ORDINARY SHARES OUTSTANDING:
Basic	163,839	160,817	163,165	160,229
Diluted	163,839	163,937	163,165	160,229
COMPREHENSIVE (LOSS) INCOME:
Net (loss) income	$ (30,136)	$ 2,364	$ (66,039)	$ (20,054)
Holding loss, net of a tax (benefit) provision of $326, $(79), $(1,055) and $(253), respectively	(2,254)	(272)	(6,765)	(873)
COMPREHENSIVE (LOSS) INCOME	(32,390)	2,092	(72,804)	(20,927)
Product sales, net
REVENUES:
Total revenues	190,787	160,808	362,055	290,771
Manufacturing and royalty revenues
REVENUES:
Total revenues	85,326	142,294	190,496	262,141
License revenue
REVENUES:
Total revenues			2,000	1,500
Research and development revenue
REVENUES:
Total revenues	$ 106	$ 615	$ 213	$ 735

CONDENSED CONSOLIDATED STATEM_2

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE (LOSS) INCOME (unaudited) (Parenthetical) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Statement [Abstract]
Tax (benefit) provision	$ 326	$ (1,382)	$ (79)	$ (174)	$ (1,055)	$ (253)

CONDENSED CONSOLIDATED STATEM_3

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (66,039)	$ (20,054)
Adjustments to reconcile net loss to cash flows from operating activities:
Depreciation and amortization	38,588	38,119
Share-based compensation expense	41,720	43,003
Deferred income taxes	(40,815)	10,806
Change in the fair value of contingent consideration	18,197	(4,518)
Loss on debt extinguishment		171
Other non-cash charges	637	1,302
Changes in assets and liabilities:
Receivables	67,382	(22,194)
Contract assets	(3,123)	5,607
Inventory	(4,569)	(11,232)
Prepaid expenses and other assets	(1,986)	2,029
Right-of-use assets	8,331	8,595
Accounts payable and accrued expenses	(29,045)	(52,629)
Contract liabilities	(4,071)	(3,108)
Operating lease liabilities	(8,911)	(7,821)
Other long-term liabilities	3,076	(159)
Cash flows provided by (used in) operating activities	19,372	(12,083)
CASH FLOWS FROM INVESTING ACTIVITIES:
Additions of property, plant and equipment	(17,753)	(14,546)
Proceeds from the sale of equipment		177
Proceeds from contingent consideration	1,043	7,889
Return of Fountain Healthcare Partners II, L.P. investment	485
Payment made for licensed Intellectual Property ("IP")		(1,000)
Purchases of investments	(194,879)	(201,774)
Sales and maturities of investments	109,925	175,499
Cash flows used in investing activities	(101,179)	(33,755)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from the issuance of ordinary shares under share-based compensation arrangements	17,992	20,498
Employee taxes paid related to net share settlement of equity awards	(17,583)	(11,120)
Proceeds from the issuance of long-term debt		23,567
Payment made for debt extinguishment		(977)
Principal payments of long-term debt	(1,500)	(750)
Cash flows (used in) provided by financing activities	(1,091)	31,218
NET DECREASE IN CASH AND CASH EQUIVALENTS	(82,898)	(14,620)
CASH AND CASH EQUIVALENTS—Beginning of period	337,544	272,961
CASH AND CASH EQUIVALENTS—End of period	254,646	258,341
Non-cash investing and financing activities:
Purchased capital expenditures included in accounts payable and accrued expenses	$ 4,863	$ 1,023

CONDENSED CONSOLIDATED STATEM_4

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (unaudited) - USD ($) $ in Thousands	Total	Ordinary Shares	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Accumulated Deficit	Treasury Stock
BALANCE at Dec. 31, 2020	$ 1,066,982	$ 1,620	$ 2,685,647	$ (1,349)	$ (1,492,849)	$ (126,087)
BALANCE (in shares) at Dec. 31, 2020		162,269,220				(3,108,079)
Issuance of ordinary shares under employee stock plans	2,053	$ 18	2,035
Issuance of ordinary shares under employee stock plans (in shares)		1,566,685
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(10,413)					$ (10,413)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)						(529,817)
Share-based compensation	15,552		15,552
Unrealized loss on marketable securities, net of tax (benefit)	(601)			(601)
Net Income (Loss)	(22,418)				(22,418)
BALANCE at Mar. 31, 2021	1,051,155	$ 1,638	2,703,234	(1,950)	(1,515,267)	$ (136,500)
BALANCE (in shares) at Mar. 31, 2021		163,835,905				(3,637,896)
BALANCE at Dec. 31, 2020	1,066,982	$ 1,620	2,685,647	(1,349)	(1,492,849)	$ (126,087)
BALANCE (in shares) at Dec. 31, 2020		162,269,220				(3,108,079)
Unrealized loss on marketable securities, net of tax (benefit)	(873)
Net Income (Loss)	(20,054)
BALANCE at Jun. 30, 2021	1,097,902	$ 1,650	2,748,584	(2,222)	(1,512,903)	$ (137,207)
BALANCE (in shares) at Jun. 30, 2021		164,965,774				(3,669,648)
BALANCE at Mar. 31, 2021	1,051,155	$ 1,638	2,703,234	(1,950)	(1,515,267)	$ (136,500)
BALANCE (in shares) at Mar. 31, 2021		163,835,905				(3,637,896)
Issuance of ordinary shares under employee stock plans	18,445	$ 12	18,433
Issuance of ordinary shares under employee stock plans (in shares)		1,129,869
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(707)					$ (707)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)						(31,752)
Share-based compensation	26,917		26,917
Unrealized loss on marketable securities, net of tax (benefit)	(272)			(272)
Net Income (Loss)	2,364				2,364
BALANCE at Jun. 30, 2021	1,097,902	$ 1,650	2,748,584	(2,222)	(1,512,903)	$ (137,207)
BALANCE (in shares) at Jun. 30, 2021		164,965,774				(3,669,648)
BALANCE at Dec. 31, 2021	1,112,584	$ 1,658	2,798,325	(3,723)	(1,541,018)	$ (142,658)
BALANCE (in shares) at Dec. 31, 2021		165,790,549				(3,853,222)
Issuance of ordinary shares under employee stock plans	1,795	$ 19	1,776
Issuance of ordinary shares under employee stock plans (in shares)		1,953,293
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(17,069)					$ (17,069)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)						(678,209)
Share-based compensation	18,494		18,494
Unrealized loss on marketable securities, net of tax (benefit)	(4,511)			(4,511)
Net Income (Loss)	(35,903)				(35,903)
BALANCE at Mar. 31, 2022	1,075,390	$ 1,677	2,818,595	(8,234)	(1,576,921)	$ (159,727)
BALANCE (in shares) at Mar. 31, 2022		167,743,842				(4,531,431)
BALANCE at Dec. 31, 2021	1,112,584	$ 1,658	2,798,325	(3,723)	(1,541,018)	$ (142,658)
BALANCE (in shares) at Dec. 31, 2021		165,790,549				(3,853,222)
Unrealized loss on marketable securities, net of tax (benefit)	(6,765)
Net Income (Loss)	(66,039)
BALANCE at Jun. 30, 2022	1,082,324	$ 1,688	2,858,422	(10,488)	(1,607,057)	$ (160,241)
BALANCE (in shares) at Jun. 30, 2022		168,782,701				(4,549,997)
BALANCE at Mar. 31, 2022	1,075,390	$ 1,677	2,818,595	(8,234)	(1,576,921)	$ (159,727)
BALANCE (in shares) at Mar. 31, 2022		167,743,842				(4,531,431)
Issuance of ordinary shares under employee stock plans	16,197	$ 11	16,186
Issuance of ordinary shares under employee stock plans (in shares)		1,038,859
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards	(514)					$ (514)
Receipt of Alkermes' shares for the exercise of stock options or to satisfy minimum tax withholding obligations related to share-based awards (in shares)						(18,566)
Share-based compensation	23,641		23,641
Unrealized loss on marketable securities, net of tax (benefit)	(2,254)			(2,254)
Net Income (Loss)	(30,136)				(30,136)
BALANCE at Jun. 30, 2022	$ 1,082,324	$ 1,688	$ 2,858,422	$ (10,488)	$ (1,607,057)	$ (160,241)
BALANCE (in shares) at Jun. 30, 2022		168,782,701				(4,549,997)

CONDENSED CONSOLIDATED STATEM_5

CONDENSED CONSOLIDATED STATEMENTS OF SHAREHOLDERS' EQUITY (unaudited) (Parenthetical) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Statement Of Stockholders Equity [Abstract]
Tax provision (benefit)	$ 326	$ (1,382)	$ (79)	$ (174)	$ (1,055)	$ (253)

The Company

The Company	6 Months Ended
	Jun. 30, 2022
Organization Consolidation And Presentation Of Financial Statements [Abstract]
The Company	1. THE COMPANY Alkermes plc is a fully-integrated, global biopharmaceutical company that applies its scientific expertise and proprietary technologies to research, develop and commercialize, both with partners and on its own, pharmaceutical products that are designed to address unmet medical needs of patients in the fields of neuroscience and oncology. Alkermes has a portfolio of proprietary commercial products focused on alcohol dependence, opioid dependence, schizophrenia and bipolar I disorder and a pipeline of product candidates in development for neurodegenerative disorders and cancer. Headquartered in Dublin, Ireland, the Company has a research and development (“R&D”) center in Waltham, Massachusetts; an R&D and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio.

Summary of Significant Accounti

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The accompanying condensed consolidated financial statements of the Company for the three and six months ended June 30, 2022 and 2021 are unaudited and have been prepared on a basis substantially consistent with the audited financial statements for the year ended December 31, 2021. The year-end condensed consolidated balance sheet data, which is presented for comparative purposes, was derived from audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the U.S. (commonly referred to as “GAAP”). In the opinion of management, the condensed consolidated financial statements include all adjustments of a normal recurring nature that are necessary to state fairly the results of operations for the reported periods. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto of the Company, which are contained in the Company’s Annual Report. The results of the Company’s operations for any interim period are not necessarily indicative of the results of the Company’s operations for any other interim period or for any full fiscal year. Principles of Consolidation The accompanying condensed consolidated financial statements include the accounts of Alkermes plc and its wholly-owned subsidiaries as disclosed in Note 2, Summary of Significant Accounting Policies, Reclassification The Company reclassified certain prior year amounts on the condensed consolidated balance sheet to conform to the current year presentation. These reclassifications had no impact on the previously reported total assets, liabilities or shareholders’ equity. Use of Estimates The preparation of the Company’s condensed consolidated financial statements in accordance with GAAP requires that Company management make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, the Company evaluates its estimates, judgments and methodologies, including, but not limited to, those related to revenue from contracts with its customers and related allowances, impairment and amortization of intangibles and long-lived assets, share-based compensation, income taxes including the valuation allowance for deferred tax assets, valuation of investments, contingent consideration and litigation. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different conditions or using different assumptions. Segment Information The Company operates as one business segment, which is the business of developing, manufacturing and commercializing medicines designed to address unmet medical needs of patients in major therapeutic areas. The Company’s chief decision maker, its Chief Executive Officer and chairman of its board of directors, reviews the Company’s operating results on an aggregate basis and manages the Company’s operations as a single operating unit. Risks and Uncertainties In March 2020, COVID-19 was declared a global pandemic by the World Health Organization. To date, COVID-19 has surfaced in nearly all regions around the world and resulted in travel restrictions and business slowdowns and/or shutdowns in affected areas. Ireland, all U.S. states, and many local jurisdictions and countries around the world have, at times during the pandemic, issued and implemented quarantines, vaccine and masking mandates, restrictive executive orders and other similar government orders, restrictions, and recommendations for their residents to help control the spread of COVID-19, and may continue to do so while the pandemic persists. Such orders, mandates, restrictions and/or recommendations, and/or the perception that additional orders, mandates, restrictions or recommendations could occur, have, at times during the pandemic, resulted in widespread interruptions and closures of businesses, including healthcare systems that serve people living with addiction and serious mental illness, work stoppages, slowdowns and/or delays, remote work policies and travel restrictions, among other effects. The COVID-19 pandemic has caused, and the Company expects may continue to cause, varying degrees of disruption to its employees and its business operations. While the Company has continued to operate its manufacturing facilities and supply its medicines throughout the pandemic, it has at times during the pandemic experienced labor or supply chain disruptions at its manufacturing facilities, and may continue to experience such disruptions while the pandemic persists. In addition, while the Company has continued to conduct R&D activities, including its ongoing clinical trials, the COVID-19 pandemic has at times impacted the timelines of certain of its early-stage discovery efforts and clinical trials, and may continue to impact such timelines while the pandemic persists. The Company works with its internal teams, its clinical investigators, R&D vendors and critical supply chain vendors to continually assess, and mitigate, the potential impact of COVID-19 on its manufacturing operations and R&D activities. A number of the marketed products from which the Company derives revenue, including manufacturing and royalty revenue, are injectable medications administered by healthcare professionals. Given developments that have transpired to date, and may continue to transpire, in response to the pandemic, including business closures, travel restrictions, quarantine, testing and/or vaccine mandates and other protocols, labor shortages, and other restrictive measures, commercial sales of these marketed products have been adversely impacted to varying degrees during the pandemic and may continue to be adversely impacted while the pandemic persists. In addition, the Company relies upon third parties for many aspects of its business, including the provision of goods and services related to the manufacture of its clinical products and its and its partners’ marketed products, the conduct of its clinical trials, and the sale of its proprietary marketed products and the marketed products of its licensees from which the Company receives manufacturing and royalty revenue. Any prolonged material disruption to the third parties on which the Company relies could negatively impact the Company’s ability to conduct business in the manner and on the timelines presently planned, which could have a material adverse impact on the Company’s business, results of operations and financial condition. Due to numerous uncertainties surrounding the ongoing COVID-19 pandemic, the actual impact of the pandemic on the Company’s financial condition and operating results may differ from its current projections. These uncertainties include, among other things, the ultimate severity and duration of the pandemic and the manner in which it continues to evolve, including the emergence, prevalence and severity of new or existing COVID-19 variants, and future developments in response thereto, which are highly uncertain and cannot be predicted as of the date of this Form 10-Q. New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board (the “FASB”) or other standard-setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued accounting pronouncements that are not yet effective will not have a material impact on its financial position or results of operations upon adoption.

Revenue from Contracts with Cus

Revenue from Contracts with Customers	6 Months Ended
	Jun. 30, 2022
Revenue From Contract With Customer [Abstract]
Revenue from Contracts with Customers	3. REVENUE FROM CONTRACTS WITH CUSTOMERS Product Sales, Net The Company’s product sales, net consist of sales in the U.S. of VIVITROL, ARISTADA and ARISTADA INITIO and, following its commercial launch in October 2021, LYBALVI, primarily to wholesalers, specialty distributors and pharmacies. During the three and six months ended June 30, 2022 and 2021, the Company recorded product sales, net, as follows: Three Months Ended June 30, Six Months Ended June 30, (In thousands) 2022 2021 2022 2021 VIVITROL $ 96,105 $ 88,417 $ 180,959 $ 162,951 ARISTADA and ARISTADA INITIO 74,622 72,391 147,107 127,820 LYBALVI 20,060 — 33,989 — Total product sales, net $ 190,787 $ 160,808 $ 362,055 $ 290,771 Manufacturing and Royalty Revenues During the three and six months ended June 30, 2022 and 2021, the Company recorded manufacturing and royalty revenues as follows: Three Months Ended June 30, 2022 Six Months Ended June 30, 2022 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total Long-acting INVEGA products (1) $ — $ 26,648 $ 26,648 $ — $ 63,702 $ 63,702 VUMERITY 5,650 20,520 26,170 17,045 39,720 56,765 RISPERDAL CONSTA 8,571 1,820 10,391 24,149 3,668 27,817 Other 11,353 10,764 22,117 23,207 19,005 42,212 $ 25,574 $ 59,752 $ 85,326 $ 64,401 $ 126,095 $ 190,496 Three Months Ended June 30, 2021 Six Months Ended June 30, 2021 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total Long-acting INVEGA products (1) $ — $ 81,072 $ 81,072 $ — $ 142,642 $ 142,642 VUMERITY 6,724 13,624 20,348 9,172 24,616 33,788 RISPERDAL CONSTA 12,003 2,448 14,451 22,686 5,927 28,613 Other 10,566 15,857 26,423 22,520 34,578 57,098 $ 29,293 $ 113,001 $ 142,294 $ 54,378 $ 207,763 $ 262,141 (1) “Long-acting INVEGA products”: INVEGA SUSTENNA/XEPLION (paliperidone palmitate), INVEGA TRINZA/TREVICTA (paliperidone palmitate) and INVEGA HAFYERA/BYANNLI (paliperidone palmitate) In November 2021, the Company received notice of partial termination of its license agreement with Janssen Pharmaceutica N.V., a subsidiary of Johnson & Johnson Corporation (“Janssen Pharmaceutica”) in respect of INVEGA SUSTENNA, INVEGA TRINZA and INVEGA HAFYERA, pursuant to which Janssen Pharmaceutica received access and rights to Alkermes’ small particle pharmaceutical compound technology, known as NanoCrystal Technology. When the partial termination became effective in February 2022, Janssen Pharmaceutica ceased paying royalties related to sales of INVEGA SUSTENNA, INVEGA TRINZA and INVEGA HAFYERA in the U.S. and the Company stopped recognizing royalty revenue related to net sales of these products in the U.S. In April 2022, the Company commenced binding arbitration proceedings related to, among other things, Janssen Pharmaceutica’s partial termination of the license agreement and Janssen Pharmaceutica’s royalty and other obligations under the agreement. Refer to Note 15, Commitments and Contingencies Contract Assets Contract assets include unbilled amounts resulting from sales under certain of the Company’s manufacturing contracts where revenue is recognized over time and $5.0 million of expected consideration from the Company’s collaboration with Biogen related to VUMERITY. The amounts included in the contract assets table below are classified as “Current assets” in the accompanying condensed consolidated balance sheets, as they relate to manufacturing processes that are completed in ten days to eight weeks Total contract assets at June 30, 2022 were as follows: (In thousands) Contract Assets Contract assets at December 31, 2021 $ 13,363 Additions 21,883 Transferred to receivables, net (18,760 ) Contract assets at June 30, 2022 $ 16,486 Contract Liabilities Contract liabilities consist of contractual obligations related to deferred revenue. At June 30, 2022 and December 31, 2021, $3.8 million and $6.3 million of the contract liabilities, respectively, were classified as “Contract liabilities–short-term” in the accompanying condensed consolidated balance sheets and $10.0 million and $11.5 million of the contract liabilities, respectively, were classified as “Other long-term liabilities” in the accompanying condensed consolidated balance sheets. Total contract liabilities at June 30, 2022 (In thousands) Contract Liabilities Contract liabilities at December 31, 2021 $ 17,830 Additions 829 Amounts recognized into revenue (4,900 ) Contract liabilities at June 30, 2022 $ 13,759

Investments

Investments	6 Months Ended
	Jun. 30, 2022
Investments Debt And Equity Securities [Abstract]
Investments	4. INVESTMENTS Investments consisted of the following (in thousands): Gross Unrealized Losses Amortized Less than Greater than Estimated June 30, 2022 Cost Gains One Year One Year Fair Value Short-term investments: Available-for-sale securities: Corporate debt securities $ 146,785 $ 4 $ (1,744 ) $ — $ 145,045 U.S. government and agency debt securities 117,944 22 (909 ) — 117,057 Non-U.S. government debt securities 64,786 — (504 ) (63 ) 64,219 Total short-term investments 329,515 26 (3,157 ) (63 ) 326,321 Long-term investments: Available-for-sale securities: Corporate debt securities 94,346 — (2,806 ) (48 ) 91,492 U.S. government and agency debt securities 73,000 — (2,364 ) (50 ) 70,586 Non-U.S. government debt securities 15,679 — (393 ) (174 ) 15,112 183,025 — (5,563 ) (272 ) 177,190 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Total long-term investments 184,845 — (5,563 ) (272 ) 179,010 Total investments $ 514,360 $ 26 $ (8,720 ) $ (335 ) $ 505,331 December 31, 2021 Short-term investments: Available-for-sale securities: Corporate debt securities $ 85,201 $ 177 $ (39 ) $ — $ 85,339 U.S. government and agency debt securities 45,349 35 (24 ) — 45,360 Non-U.S. government debt securities 68,046 75 (53 ) — 68,068 Total short-term investments 198,596 287 (116 ) — 198,767 Long-term investments: Available-for-sale securities: Corporate debt securities 111,793 — (654 ) — 111,139 U.S. government and agency debt securities 81,296 — (517 ) — 80,779 Non-U.S. government debt securities 35,902 — (210 ) — 35,692 228,991 — (1,381 ) — 227,610 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Total long-term investments 230,811 — (1,381 ) — 229,430 Total investments $ 429,407 $ 287 $ (1,497 ) $ — $ 428,197 At June 30, 2022, the Company reviewed its investment portfolio to assess whether the unrealized losses on its available-for-sale investments were temporary. Investments with unrealized losses consisted primarily of corporate debt securities and debt securities issued and backed by U.S. agencies and the U.S. government. At June 30, 2022, the aggregate estimated fair value of investments in an unrealized loss position was $492.1 million. The Company has the intent and ability to hold these investments until recovery, which may be at maturity. In January 2022, the Company purchased a convertible promissory note in the principal amount of $0.5 million from Synchronicity Pharma, Inc. (“Synchronicity”), a related party, that matures on the earlier of September 30, 2022, the closing of a preferred equity financing, the closing of a merger, business combination or sale of stock resulting in Synchronicity’s stockholders owning less than 50 % of the surviving entity, or an event of default. The convertible promissory note was classified as an available-for-sale corporate debt instrument. In May 2014, the Company entered into an agreement to invest in a partnership, Fountain Healthcare Partners II, L.P. of Ireland (“Fountain”), which was created to carry on the business of investing exclusively in companies and businesses engaged in the healthcare, pharmaceutical and life sciences sectors. As of June 30, 2022, the Company’s total contribution in Fountain was equal to €8.0 million, and its commitment represented approximately 7% of the partnership’s total funding. The Company is accounting for its investment in Fountain under the equity method. During the three months ended March 31, 2022, one of the companies within the Fountain portfolio was acquired by a third party. The Company’s proportional share of the proceeds from this transaction was $1.1 million, of which $1.0 million was received during the three months ended March 31, 2022 and the remaining $0.1 million is being held in escrow until May 2023. The transaction was accounted for under the cumulative earnings approach whereby the return on investment of $0.6 million was recorded as a gain within “Other income (expense), net” in the accompanying condensed consolidated statements of operations and comprehensive (loss) income and the return of investment of $0.5 million was recorded as a reduction in the Company’s net investment in Fountain. The Company’s net investment in Fountain was $6.7 million and $6.1 million at June 30, 2022 and December 31, 2021, respectively, and was included within “Other assets” in the accompanying condensed consolidated balance sheets. During the three and six months ended June 30, 2022, the Company recorded an increase of $1.1 million in its investment in Fountain, which represented the Company’s proportional share of Fountain’s net gains. Realized gains and losses on the sales and maturities of investments, which were identified using the specific identification method, were as follows: Six Months Ended June 30, (In thousands) 2022 2021 Proceeds from the sales and maturities of investments $ 109,925 $ 175,499 Realized gains $ — $ — Realized losses $ — $ 977 The Company’s available-for-sale and held-to-maturity securities at June 30, 2022 had contractual maturities in the following periods: Available-for-sale Held-to-maturity Amortized Estimated Amortized Estimated (In thousands) Cost Fair Value Cost Fair Value Within 1 year $ 326,560 $ 323,341 $ 1,820 $ 1,820 After 1 year through 5 years 185,980 180,170 — — Total $ 512,540 $ 503,511 $ 1,820 $ 1,820

Fair Value

Fair Value	6 Months Ended
	Jun. 30, 2022
Fair Value Disclosures [Abstract]
Fair Value	5. FAIR VALUE The following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy and the valuation techniques that the Company utilized to determine such fair value: June 30, (In thousands) 2022 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 14,980 $ 14,980 $ — $ — U.S. government and agency debt securities 187,643 153,482 34,161 — Corporate debt securities 236,537 — 236,037 500 Non-U.S. government debt securities 79,331 — 79,331 — Contingent consideration 3,779 — — 3,779 Total $ 522,270 $ 168,462 $ 349,529 $ 4,279 December 31, 2021 Level 1 Level 2 Level 3 Assets: U.S. government and agency debt securities $ 126,139 $ 96,597 $ 29,542 $ — Corporate debt securities 196,478 — 196,478 — Non-U.S. government debt securities 103,760 — 103,760 — Contingent consideration 23,048 — — 23,048 Total $ 449,425 $ 96,597 $ 329,780 $ 23,048 The Company transfers its financial assets and liabilities, measured at fair value on a recurring basis, between the fair value hierarchies at the end of each reporting period. There were no transfers of any securities between levels during the six months ended June 30, 2022. The following table is a rollforward of the fair value of the Company’s investments with fair values that were determined using Level 3 inputs at June 30, 2022: (In thousands) Fair Value Balance, January 1, 2022 $ 23,048 Purchase of corporate debt security 500 Change in the fair value of contingent consideration (18,197 ) Milestone and royalty payments received by the Company related to contingent consideration (1,043 ) Royalty payments due to the Company related to contingent consideration (29 ) Balance, June 30, 2022 $ 4,279 The Company’s investments in U.S. government and agency debt securities, non-U.S. government agency debt securities and corporate debt securities classified as Level 2 within the fair value hierarchy were initially valued at the transaction price and subsequently valued, at the end of each reporting period, utilizing market-observable data. The market-observable data included reportable trades, benchmark yields, credit spreads, broker/dealer quotes, bids, offers, current spot rates and other industry and economic events. The Company validated the prices developed using the market-observable data by obtaining market values from other pricing sources, analyzing pricing data in certain instances and confirming that the relevant markets are active. In April 2015, the Company sold its Gainesville, GA manufacturing facility, the related manufacturing and royalty revenue associated with certain products manufactured at the facility, and the rights to intravenous/intramuscular (“IV/IM”) and parenteral forms of Meloxicam to Recro Pharma, Inc. (“Recro”) and Recro Gainesville LLC (such transaction, the “Gainesville Transaction”). The Gainesville Transaction included in the purchase price contingent consideration tied to low double digit royalties on net sales of the IV/IM and parenteral forms of Meloxicam and any other product with the same active ingredient as Meloxicam IV/IM that is discovered or identified using certain of the Company’s IP to which Recro was provided a right of use, through license or transfer, pursuant to the Gainesville Transaction (such products, the “Meloxicam Products”), and milestone payments upon the achievement of certain regulatory and sales milestones related to the Meloxicam Products. In November 2019, Recro spun out its acute care segment to Baudax Bio, Inc. (“Baudax”), a publicly-traded pharmaceutical company. As part of this transaction, Recro’s obligations to pay certain contingent consideration from the Gainesville Transaction were assigned and/or transferred to Baudax. At June 30, 2022, the Company determined the fair value of the contingent consideration to be received as follows: • As of December 31, 2021, the Company had received $7.8 million in milestone payments and was due to receive an additional $38.6 million related to the U.S. Food and Drug Administration (“FDA”) approval of the New Drug Application (“NDA”) for ANJESO. This amount is due in six equal, annual installments from March 2022 through March 2027. At June 30, 2022, Baudax had paid the Company $1.0 million of the $6.4 million payment that was due in March 2022; • The Company is entitled to receive future royalties on net sales of Meloxicam Products; and • The Company is entitled to receive payments of up to $80.0 million related to the achievement of certain sales milestones on future sales of the Meloxicam Products. At June 30, 2022, the Company did not believe it was probable that any of the sales milestones would be achieved. In Baudax’s Quarterly Report on Form 10-Q for the three months ended March 31, 2022, Baudax included disclosures regarding its ability to continue as a going concern and its March 2022 reduction in workforce by approximately 80%, which was designed to reduce its operational expenses and conserve its cash resources. In light of Baudax’s disclosures regarding its ability to continue as a going concern and the fact that, as of June 30, 2022, Baudax had paid $1.0 million of the $6.4 million that was due in March 2022, the Company has applied a 100% likelihood that Baudax would default on its obligations and applied a recovery rate of 9% based on an analysis performed by Standard and Poor’s regarding post-default recoveries. However, for avoidance of doubt, the Company has not waived its right to receive any portion of the payments owing by Baudax. For discussion on the calculation of the fair value of the contingent consideration at December 31, 2021, refer to Note 5, Fair Value within the “Notes to Consolidated Financial Statements” in the At June 30, 2022 and December 31, 2021, the Company determined that the fair value of the contingent consideration was $3.8 million and $23.0 million, respectively. At June 30, 2022 and December 31, 2021, $3.8 million and $6.4 million, respectively, of the fair value of the contingent consideration was included within “Prepaid expenses and other current assets” in the accompanying condensed consolidated balance sheets, and none and $16.6 million, respectively, of the fair value of the contingent consideration was included within “Other assets” in the accompanying condensed consolidated balance sheets. Changes in the fair value of the contingent consideration are recorded within “Change in the fair value of contingent consideration” in the accompanying condensed consolidated statements of operations and comprehensive (loss) income. The carrying amounts reflected in the accompanying condensed consolidated balance sheets for cash and cash equivalents, accounts receivable, contract assets, other current assets, accounts payable and accrued expenses approximate fair value due to their short-term nature. The estimated fair value of the Company’s long-term debt under its amended and restated credit agreement (such debt, the “2026 Term Loans”), which was based on quoted market price indications (Level 2 in the fair value hierarchy) and which may not be representative of actual values that could have been, or will be, realized in the future, was $277.7 million and $285.8 million at June 30, 2022 and December 31, 2021, respectively.

Inventory

Inventory	6 Months Ended
	Jun. 30, 2022
Inventory Disclosure [Abstract]
Inventory	6. INVENTORY Inventory is stated at the lower of cost and net realizable value. Cost is determined using the first-in, first-out method. Inventory consisted of the following: June 30, December 31, (In thousands) 2022 2021 Raw materials $ 52,870 $ 56,125 Work in process 70,437 59,105 Finished goods ( 1) 32,301 35,105 Total inventory $ 155,608 $ 150,335 (1) At June 30, 2022 and December 31, 2021, the Company had $25.7 million and $25.1 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

Property, Plant and Equipment

Property, Plant and Equipment	6 Months Ended
	Jun. 30, 2022
Property Plant And Equipment [Abstract]
Property, Plant and Equipment	7. PROPERTY, PLANT AND EQUIPMENT Property, plant and equipment consisted of the following: June 30, December 31, (In thousands) 2022 2021 Land $ 6,560 $ 6,560 Building and improvements 193,914 192,920 Furniture, fixtures and equipment 406,868 398,099 Leasehold improvements 52,526 52,526 Construction in progress 92,839 86,512 Subtotal 752,707 736,617 Less: accumulated depreciation (415,561 ) (395,563 ) Total property, plant and equipment, net $ 337,146 $ 341,054

Goodwill and Intangible Assets

Goodwill and Intangible Assets	6 Months Ended
	Jun. 30, 2022
Goodwill And Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets	8. GOODWILL AND INTANGIBLE ASSETS Goodwill and intangible assets consisted of the following: June 30, 2022 (In thousands) Weighted Amortizable Life (Years) Gross Carrying Amount Accumulated Amortization Net Carrying Amount Goodwill $ 92,873 $ — $ 92,873 Finite-lived intangible assets: Collaboration agreements 12 $ 465,590 $ (421,331 ) $ 44,259 Capitalized IP 11-13 118,160 (106,408 ) 11,752 Total $ 583,750 $ (527,739 ) $ 56,011 Based on the Company’s most recent analysis, amortization of intangible assets included in the accompanying condensed consolidated balance sheet at June 30, 2022 is expected to be approximately $35.0 million, $35.0 million and $1.0 million in the years ending December 31, 2022 through 2024, respectively. Although the Company believes that such analysis, and the available information and assumptions underlying such analysis, are reasonable, given the inherent risks and uncertainties underlying its expectations regarding such future revenues, there is the potential for the Company’s actual results to vary significantly from such expectations. If revenues are projected to change, the related amortization of the intangible assets will change in proportion to the change in revenues.

Leases

Leases	6 Months Ended
	Jun. 30, 2022
Leases [Abstract]
Leases	9. LEASES Future lease payments under non-cancelable leases at June 30, 2022 and December 31, 2021 consisted of the following: June 30, December 31, (In thousands) 2022 2021 2022 $ 9,012 $ 17,991 2023 18,206 17,329 2024 18,476 17,535 2025 18,750 17,808 2026 14,719 13,777 Thereafter 95,289 95,229 Total operating lease payments $ 174,452 $ 179,669 Less: imputed interest (58,676 ) (59,267 ) Total operating lease liabilities $ 115,776 $ 120,402 At June 30, 2022, the weighted average incremental borrowing rate and the weighted average remaining lease term for all operating leases held by the Company were 5.21% and 11.1 years, respectively. Cash paid for lease liabilities was $4.5 million and $8.9 million during the three and six months ended June 30, 2022, respectively, compared to $4.4 million and $8.1 million during the three and six months ended June 30, 2021, respectively. The Company recorded operating lease expense of $4.2 million and $8.3 million during the three and six months ended June 30, 2022, respectively, as compared to $4.4 million and $8.6 million during the three and six months ended June 30, 2021, respectively.

Accounts Payable and Accrued Ex

Accounts Payable and Accrued Expenses	6 Months Ended
	Jun. 30, 2022
Payables And Accruals [Abstract]
Accounts Payable and Accrued Expenses	10. ACCOUNTS PAYABLE AND ACCRUED EXPENSES Accounts payable and accrued expenses consisted of the following: June 30, December 31, (In thousands) 2022 2021 Accounts payable $ 40,047 $ 55,721 Accrued compensation 52,865 77,256 Accrued other 93,902 75,514 Total accounts payable and accrued expenses $ 186,814 $ 208,491 A summary of the Company’s current provision for sales discounts, allowances and reserves is as follows: June 30, December 31, (In thousands) 2022 2021 Medicaid rebates $ 191,458 $ 195,413 Product discounts 13,956 14,951 Medicare Part D 13,087 14,348 Other 10,472 12,504 Total accrued sales discounts, allowances and reserves $ 228,973 $ 237,216

Long-term Debt

Long-term Debt	6 Months Ended
	Jun. 30, 2022
Debt Disclosure [Abstract]
Long-term Debt	11. LONG-TERM DEBT Long-term debt consisted of the following: June 30, December 31, (In thousands) 2022 2021 2026 Term Loans, due March 12, 2026 $ 294,537 $ 295,804 Less: current portion (3,000 ) (3,000 ) Long-term debt $ 291,537 $ 292,804 In March 2021, the Company amended and refinanced its existing term loans, resulting in the 2026 Term Loans (such refinancing, the “Term Loan Refinancing”). The 2026 Term Loans mature on March 12, 2026 and bear interest payable at LIBOR plus 2.50% with a LIBOR floor of 0.5%. The 2026 Term Loans have an incremental facility capacity in the amount of $175.0 million plus additional amounts, provided that the Company meets certain conditions, including a specified leverage ratio. The Company was in compliance with its debt covenants at June 30, 2022. Included in “Interest expense” in the accompanying condensed consolidated statement of operations and comprehensive (loss) income in the six months ended June 30, 2021 was $2.1 million related to the Term Loan Refinancing. Refer to Note 11, Long-Term Debt

Share-based Compensation

Share-based Compensation	6 Months Ended
	Jun. 30, 2022
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-based Compensation	12. SHARE-BASED COMPENSATION The following table presents share-based compensation expense included in the accompanying condensed consolidated statements of operations and comprehensive (loss) income: Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Cost of goods manufactured and sold $ 2,401 $ 2,683 $ 4,783 $ 4,861 Research and development 7,222 7,131 12,830 11,194 Selling, general and administrative 13,754 17,738 24,107 26,948 Total share-based compensation expense $ 23,377 $ 27,552 $ 41,720 $ 43,003 At June 30, 2022 and December 31, 2021, $2.8 million and $2.3 million, respectively, of share-based compensation expense was capitalized and recorded as “Inventory” in the accompanying condensed consolidated balance sheets.

(Loss) Earnings Per Share

(Loss) Earnings Per Share	6 Months Ended
	Jun. 30, 2022
Earnings Per Share [Abstract]
(Loss) Earnings Per Share	13. (LOSS) EARNINGS PER SHARE Basic (loss) earnings per ordinary share is calculated based upon net (loss) income available to holders of ordinary shares divided by the weighted average number of ordinary shares outstanding. For the calculation of diluted (loss) earnings per ordinary share, the Company adjusts the weighted average number of ordinary shares outstanding for the effect of outstanding ordinary share equivalents such as stock options and restricted stock unit awards. Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Numerator: Net (loss) income $ (30,136 ) $ 2,364 $ (66,039 ) $ (20,054 ) Denominator: Weighted average number of ordinary shares outstanding 163,839 160,817 163,165 160,229 Effect of dilutive securities: Stock options — 461 — — Restricted stock unit awards — 2,659 — — Dilutive ordinary share equivalents — 3,120 — — Shares used in calculating diluted (loss) earnings per share 163,839 163,937 163,165 160,229 The following outstanding ordinary share equivalents were not included in the net (loss) earnings per ordinary share calculation because the effect would have been anti-dilutive: Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Stock options 12,781 15,465 12,677 15,265 Restricted stock unit awards 4,718 596 6,251 3,189 Total 17,499 16,061 18,928 18,454

Income Taxes

Income Taxes	6 Months Ended
	Jun. 30, 2022
Income Tax Disclosure [Abstract]
Income Taxes	14. INCOME TAXES The Company recognizes income taxes under the asset and liability method. Deferred income taxes are recognized for differences between the financial reporting and tax bases of assets and liabilities at enacted statutory tax rates in effect for the years in which the differences are expected to reverse. The effect on deferred taxes of a change in tax rates is recognized in income in the period that includes the enactment date. In determining future taxable income, the Company is responsible for assumptions that it utilizes including the amount of Irish and non-Irish pre‑tax operating income, the reversal of temporary differences and the implementation of feasible and prudent tax planning strategies. These assumptions require significant judgment about the forecasts of future taxable income and are consistent with the plans and estimates that the Company uses to manage the underlying business. The Company recorded income tax benefits of $3.1 million and $12.2 million during the three and six months ended June 30, 2022, respectively, which were primarily due to a change to Section 174 of the Tax Cuts and Jobs Act of 2017 (as amended, the “TCJA”), which became effective on January 1, 2022. Under the TCJA, the Company is required to capitalize, and subsequently amortize, R&D expenses over five years for research activities conducted in the U.S. and over fifteen years for research activities conducted outside of the U.S. The capitalization of R&D expenses during these periods resulted in an increase to the Company’s U.S. taxable income and foreign derived intangible income (“FDII”), resulting in a significant increase in the Company’s FDII deduction.

Commitments and Contingent Liab

Commitments and Contingent Liabilities	6 Months Ended
	Jun. 30, 2022
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingent Liabilities	15. COMMITMENTS AND CONTINGENT LIABILITIES Litigation From time to time, the Company may be subject to legal proceedings and claims in the ordinary course of business. On a quarterly basis, the Company reviews the status of each significant matter and assesses its potential financial exposure. If the potential loss from any claim, asserted or unasserted, or legal proceeding is considered probable and the amount can be reasonably estimated, the Company would accrue a liability for the estimated loss. Because of uncertainties related to claims and litigation, accruals are based on the Company’s best estimates, utilizing all available information. On a periodic basis, as additional information becomes available, or based on specific events such as the outcome of litigation or settlement of claims, the Company may reassess the potential liability related to these matters and may revise these estimates, which could result in material adverse adjustments to the Company’s operating results. At June 30, 2022, there were no potential material losses from claims, asserted or unasserted, or legal proceedings that the Company determined were probable of occurring. Janssen Arbitration Proceedings In April 2022, Alkermes Pharma Ireland Limited commenced binding arbitration proceedings to settle, among other things, whether, notwithstanding Janssen Pharmaceutica’s partial termination of two license agreements with the Company, it has a continuing obligation to pay royalties on sales in the U.S. of INVEGA SUSTENNA, INVEGA TRINZA, INVEGA HAFYERA and CABENUVA, products developed under or enabled by these license agreements. The arbitration is to be conducted pursuant to the Institute for Conflict Prevention and Resolution (CPR) Rules for Non-Administered Arbitration. The request for arbitration seeks, among other remedies, a declaration that Janssen Pharmaceutica is in breach of the license agreements and a resumption of royalty payments for sales of the relevant products in the U.S. INVEGA SUSTENNA ANDA Litigation Janssen Pharmaceutica and Janssen Pharmaceuticals, Inc. initiated patent infringement lawsuits in the U.S. District Court for the District of New Jersey (the “NJ District Court”) in January 2018 against Teva Pharmaceuticals USA, Inc. (“Teva”) and Teva Pharmaceuticals Industries, Ltd. (“Teva PI”) (such lawsuit, the “Teva Lawsuit”), in August 2019 against Mylan Laboratories Limited (“Mylan Labs”) and other Mylan entities (the “Mylan Lawsuit”) and in December 2019 against Pharmascience, Inc. (“Pharmascience”), Mallinckrodt plc, and SpecGX LLC (the “Pharmascience Lawsuit”), and in the U.S. District Court for the District of Delaware in December 2021 against Tolmar Holding, Inc., Tolmar Pharmaceuticals, Inc., Tolmar Therapeutics, Inc., and Tolmar, Inc. (“Tolmar” and such lawsuit, the “Tolmar Lawsuit”), following the respective filings by each of Teva, Mylan Labs, Pharmascience and Tolmar of an Abbreviated New Drug Application (“ANDA”) seeking approval from the FDA to market a generic version of INVEGA SUSTENNA before the expiration of U.S. Patent No. 9,439,906. In October 2021, the NJ District Court entered a judgment in favor of the Janssen entities in the Teva Lawsuit. In December 2021, the NJ District Court entered a judgment in favor of the Janssen entities in the Mylan Lawsuit, based on the parties’ prior stipulation to be bound by the judgment in the Teva Lawsuit. The Teva entities and Mylan Labs each filed notices of appeal of their respective judgments with the U.S. Court of Appeals for the Federal Circuit, which were consolidated in January 2022. A trial was scheduled in the Tolmar Lawsuit for October 2023. The Pharmascience Lawsuit remains pending. The Company is not a party to any of these proceedings. INVEGA TRINZA ANDA Litigation In September 2020, Janssen Pharmaceutica, Janssen Pharmaceuticals, Inc., and Janssen Research & Development, LLC, initiated a patent infringement lawsuit in the NJ District Court against Mylan Labs, Mylan, and Mylan Institutional LLC following the filing by Mylan Labs of an ANDA seeking approval from the FDA to market a generic version of INVEGA TRINZA before the expiration of U.S. Patent No. 10,143,693. Requested judicial remedies include recovery of litigation costs and injunctive relief. A trial has been scheduled for October 2022. The Company is not a party to this proceeding. VIVITROL ANDA Litigation In September 2020, Alkermes, Inc. and Alkermes Pharma Ireland Limited filed a patent infringement lawsuit in the NJ District Court against Teva and Teva PI following the filing by Teva of an ANDA seeking approval from the FDA to engage in the commercial manufacture, use or sale of a generic version of VIVITROL (naltrexone for extended-release injectable suspension) before the expiration of the Company’s U.S. Patent No. 7,919,499. Teva filed its a nswer in November 2020, which included counterclaims against the Company. The Company filed its r eply to Teva’s counterclaims in December 2020. The Company intends to vigorously defend its IP . The filing of the lawsuit triggered a stay of FDA approval of the ANDA for up to 30 months in accordance with the U.S. Drug Price Competition and Patent Term Restoration Act of 1984 (the Hatch-Waxman Act). Government Matters The Company has received a subpoena and civil investigative demands from U.S. state and federal governmental authorities for documents related to VIVITROL. The Company is cooperating with the investigations. Product Liability and Other Legal Proceedings The Company is involved in litigation and other legal proceedings incidental to its normal business activities, including product liability cases alleging that the FDA-approved VIVITROL labeling was inadequate and caused the users of the product to suffer from opioid overdose and death. The Company intends to vigorously defend itself in these matters. While the outcome of any of these proceedings cannot be accurately predicted, the Company does not believe the ultimate resolution of any of these existing proceedings would have a material adverse effect on the Company’s business or financial condition.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The accompanying condensed consolidated financial statements of the Company for the three and six months ended June 30, 2022 and 2021 are unaudited and have been prepared on a basis substantially consistent with the audited financial statements for the year ended December 31, 2021. The year-end condensed consolidated balance sheet data, which is presented for comparative purposes, was derived from audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the U.S. (commonly referred to as “GAAP”). In the opinion of management, the condensed consolidated financial statements include all adjustments of a normal recurring nature that are necessary to state fairly the results of operations for the reported periods. These financial statements should be read in conjunction with the audited consolidated financial statements and notes thereto of the Company, which are contained in the Company’s Annual Report. The results of the Company’s operations for any interim period are not necessarily indicative of the results of the Company’s operations for any other interim period or for any full fiscal year.
Principles of Consolidation	Principles of Consolidation The accompanying condensed consolidated financial statements include the accounts of Alkermes plc and its wholly-owned subsidiaries as disclosed in Note 2, Summary of Significant Accounting Policies,
Reclassification	Reclassification The Company reclassified certain prior year amounts on the condensed consolidated balance sheet to conform to the current year presentation. These reclassifications had no impact on the previously reported total assets, liabilities or shareholders’ equity.
Use of Estimates	Use of Estimates The preparation of the Company’s condensed consolidated financial statements in accordance with GAAP requires that Company management make estimates, judgments and assumptions that may affect the reported amounts of assets, liabilities, revenues and expenses, and related disclosure of contingent assets and liabilities. On an ongoing basis, the Company evaluates its estimates, judgments and methodologies, including, but not limited to, those related to revenue from contracts with its customers and related allowances, impairment and amortization of intangibles and long-lived assets, share-based compensation, income taxes including the valuation allowance for deferred tax assets, valuation of investments, contingent consideration and litigation. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgments about the carrying values of assets and liabilities. Actual results may differ from these estimates under different conditions or using different assumptions.
Segment Information	Segment Information The Company operates as one business segment, which is the business of developing, manufacturing and commercializing medicines designed to address unmet medical needs of patients in major therapeutic areas. The Company’s chief decision maker, its Chief Executive Officer and chairman of its board of directors, reviews the Company’s operating results on an aggregate basis and manages the Company’s operations as a single operating unit.
Risks and Uncertainties	Risks and Uncertainties In March 2020, COVID-19 was declared a global pandemic by the World Health Organization. To date, COVID-19 has surfaced in nearly all regions around the world and resulted in travel restrictions and business slowdowns and/or shutdowns in affected areas. Ireland, all U.S. states, and many local jurisdictions and countries around the world have, at times during the pandemic, issued and implemented quarantines, vaccine and masking mandates, restrictive executive orders and other similar government orders, restrictions, and recommendations for their residents to help control the spread of COVID-19, and may continue to do so while the pandemic persists. Such orders, mandates, restrictions and/or recommendations, and/or the perception that additional orders, mandates, restrictions or recommendations could occur, have, at times during the pandemic, resulted in widespread interruptions and closures of businesses, including healthcare systems that serve people living with addiction and serious mental illness, work stoppages, slowdowns and/or delays, remote work policies and travel restrictions, among other effects. The COVID-19 pandemic has caused, and the Company expects may continue to cause, varying degrees of disruption to its employees and its business operations. While the Company has continued to operate its manufacturing facilities and supply its medicines throughout the pandemic, it has at times during the pandemic experienced labor or supply chain disruptions at its manufacturing facilities, and may continue to experience such disruptions while the pandemic persists. In addition, while the Company has continued to conduct R&D activities, including its ongoing clinical trials, the COVID-19 pandemic has at times impacted the timelines of certain of its early-stage discovery efforts and clinical trials, and may continue to impact such timelines while the pandemic persists. The Company works with its internal teams, its clinical investigators, R&D vendors and critical supply chain vendors to continually assess, and mitigate, the potential impact of COVID-19 on its manufacturing operations and R&D activities. A number of the marketed products from which the Company derives revenue, including manufacturing and royalty revenue, are injectable medications administered by healthcare professionals. Given developments that have transpired to date, and may continue to transpire, in response to the pandemic, including business closures, travel restrictions, quarantine, testing and/or vaccine mandates and other protocols, labor shortages, and other restrictive measures, commercial sales of these marketed products have been adversely impacted to varying degrees during the pandemic and may continue to be adversely impacted while the pandemic persists. In addition, the Company relies upon third parties for many aspects of its business, including the provision of goods and services related to the manufacture of its clinical products and its and its partners’ marketed products, the conduct of its clinical trials, and the sale of its proprietary marketed products and the marketed products of its licensees from which the Company receives manufacturing and royalty revenue. Any prolonged material disruption to the third parties on which the Company relies could negatively impact the Company’s ability to conduct business in the manner and on the timelines presently planned, which could have a material adverse impact on the Company’s business, results of operations and financial condition. Due to numerous uncertainties surrounding the ongoing COVID-19 pandemic, the actual impact of the pandemic on the Company’s financial condition and operating results may differ from its current projections. These uncertainties include, among other things, the ultimate severity and duration of the pandemic and the manner in which it continues to evolve, including the emergence, prevalence and severity of new or existing COVID-19 variants, and future developments in response thereto, which are highly uncertain and cannot be predicted as of the date of this Form 10-Q.
New Accounting Pronouncements	New Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board (the “FASB”) or other standard-setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued accounting pronouncements that are not yet effective will not have a material impact on its financial position or results of operations upon adoption.

Revenue from Contracts with C_2

Revenue from Contracts with Customers (Tables)	6 Months Ended
	Jun. 30, 2022
Schedule of Contract Assets and Contract Liabilities	Total contract assets at June 30, 2022 were as follows: (In thousands) Contract Assets Contract assets at December 31, 2021 $ 13,363 Additions 21,883 Transferred to receivables, net (18,760 ) Contract assets at June 30, 2022 $ 16,486 Total contract liabilities at June 30, 2022 (In thousands) Contract Liabilities Contract liabilities at December 31, 2021 $ 17,830 Additions 829 Amounts recognized into revenue (4,900 ) Contract liabilities at June 30, 2022 $ 13,759
Product sales, net
Schedule of Disaggregation of Revenues	During the three and six months ended June 30, 2022 and 2021, the Company recorded product sales, net, as follows: Three Months Ended June 30, Six Months Ended June 30, (In thousands) 2022 2021 2022 2021 VIVITROL $ 96,105 $ 88,417 $ 180,959 $ 162,951 ARISTADA and ARISTADA INITIO 74,622 72,391 147,107 127,820 LYBALVI 20,060 — 33,989 — Total product sales, net $ 190,787 $ 160,808 $ 362,055 $ 290,771
Manufacturing and royalty revenues
Schedule of Disaggregation of Revenues	During the three and six months ended June 30, 2022 and 2021, the Company recorded manufacturing and royalty revenues as follows: Three Months Ended June 30, 2022 Six Months Ended June 30, 2022 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total Long-acting INVEGA products (1) $ — $ 26,648 $ 26,648 $ — $ 63,702 $ 63,702 VUMERITY 5,650 20,520 26,170 17,045 39,720 56,765 RISPERDAL CONSTA 8,571 1,820 10,391 24,149 3,668 27,817 Other 11,353 10,764 22,117 23,207 19,005 42,212 $ 25,574 $ 59,752 $ 85,326 $ 64,401 $ 126,095 $ 190,496 Three Months Ended June 30, 2021 Six Months Ended June 30, 2021 (In thousands) Manufacturing Revenue Royalty Revenue Total Manufacturing Revenue Royalty Revenue Total Long-acting INVEGA products (1) $ — $ 81,072 $ 81,072 $ — $ 142,642 $ 142,642 VUMERITY 6,724 13,624 20,348 9,172 24,616 33,788 RISPERDAL CONSTA 12,003 2,448 14,451 22,686 5,927 28,613 Other 10,566 15,857 26,423 22,520 34,578 57,098 $ 29,293 $ 113,001 $ 142,294 $ 54,378 $ 207,763 $ 262,141 (1) “Long-acting INVEGA products”: INVEGA SUSTENNA/XEPLION (paliperidone palmitate), INVEGA TRINZA/TREVICTA (paliperidone palmitate) and INVEGA HAFYERA/BYANNLI (paliperidone palmitate)

Investments (Tables)

Investments (Tables)	6 Months Ended
	Jun. 30, 2022
Investments Debt And Equity Securities [Abstract]
Schedule of Investments	Investments consisted of the following (in thousands): Gross Unrealized Losses Amortized Less than Greater than Estimated June 30, 2022 Cost Gains One Year One Year Fair Value Short-term investments: Available-for-sale securities: Corporate debt securities $ 146,785 $ 4 $ (1,744 ) $ — $ 145,045 U.S. government and agency debt securities 117,944 22 (909 ) — 117,057 Non-U.S. government debt securities 64,786 — (504 ) (63 ) 64,219 Total short-term investments 329,515 26 (3,157 ) (63 ) 326,321 Long-term investments: Available-for-sale securities: Corporate debt securities 94,346 — (2,806 ) (48 ) 91,492 U.S. government and agency debt securities 73,000 — (2,364 ) (50 ) 70,586 Non-U.S. government debt securities 15,679 — (393 ) (174 ) 15,112 183,025 — (5,563 ) (272 ) 177,190 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Total long-term investments 184,845 — (5,563 ) (272 ) 179,010 Total investments $ 514,360 $ 26 $ (8,720 ) $ (335 ) $ 505,331 December 31, 2021 Short-term investments: Available-for-sale securities: Corporate debt securities $ 85,201 $ 177 $ (39 ) $ — $ 85,339 U.S. government and agency debt securities 45,349 35 (24 ) — 45,360 Non-U.S. government debt securities 68,046 75 (53 ) — 68,068 Total short-term investments 198,596 287 (116 ) — 198,767 Long-term investments: Available-for-sale securities: Corporate debt securities 111,793 — (654 ) — 111,139 U.S. government and agency debt securities 81,296 — (517 ) — 80,779 Non-U.S. government debt securities 35,902 — (210 ) — 35,692 228,991 — (1,381 ) — 227,610 Held-to-maturity securities: Certificates of deposit 1,820 — — — 1,820 Total long-term investments 230,811 — (1,381 ) — 229,430 Total investments $ 429,407 $ 287 $ (1,497 ) $ — $ 428,197
Schedule of Proceeds from Sales and Maturities of Marketable Securities Plus Resulting Realized Gains and Losses	Realized gains and losses on the sales and maturities of investments, which were identified using the specific identification method, were as follows: Six Months Ended June 30, (In thousands) 2022 2021 Proceeds from the sales and maturities of investments $ 109,925 $ 175,499 Realized gains $ — $ — Realized losses $ — $ 977
Schedule of Contractual Maturities of Available-for-Sale and Held-to-Maturity Securities	The Company’s available-for-sale and held-to-maturity securities at June 30, 2022 had contractual maturities in the following periods: Available-for-sale Held-to-maturity Amortized Estimated Amortized Estimated (In thousands) Cost Fair Value Cost Fair Value Within 1 year $ 326,560 $ 323,341 $ 1,820 $ 1,820 After 1 year through 5 years 185,980 180,170 — — Total $ 512,540 $ 503,511 $ 1,820 $ 1,820

Fair Value (Tables)

Fair Value (Tables)	6 Months Ended
	Jun. 30, 2022
Fair Value Disclosures [Abstract]
Summary of the Company's Assets and Liabilities Measured at Fair Value on a Recurring Basis	The following table presents information about the Company’s assets and liabilities that are measured at fair value on a recurring basis and indicates the fair value hierarchy and the valuation techniques that the Company utilized to determine such fair value: June 30, (In thousands) 2022 Level 1 Level 2 Level 3 Assets: Cash equivalents $ 14,980 $ 14,980 $ — $ — U.S. government and agency debt securities 187,643 153,482 34,161 — Corporate debt securities 236,537 — 236,037 500 Non-U.S. government debt securities 79,331 — 79,331 — Contingent consideration 3,779 — — 3,779 Total $ 522,270 $ 168,462 $ 349,529 $ 4,279 December 31, 2021 Level 1 Level 2 Level 3 Assets: U.S. government and agency debt securities $ 126,139 $ 96,597 $ 29,542 $ — Corporate debt securities 196,478 — 196,478 — Non-U.S. government debt securities 103,760 — 103,760 — Contingent consideration 23,048 — — 23,048 Total $ 449,425 $ 96,597 $ 329,780 $ 23,048
Rollforward of the Fair Value of the Assets Determined using Level 3 Inputs	The following table is a rollforward of the fair value of the Company’s investments with fair values that were determined using Level 3 inputs at June 30, 2022: (In thousands) Fair Value Balance, January 1, 2022 $ 23,048 Purchase of corporate debt security 500 Change in the fair value of contingent consideration (18,197 ) Milestone and royalty payments received by the Company related to contingent consideration (1,043 ) Royalty payments due to the Company related to contingent consideration (29 ) Balance, June 30, 2022 $ 4,279

Inventory (Tables)

Inventory (Tables)	6 Months Ended
	Jun. 30, 2022
Inventory Disclosure [Abstract]
Schedule of Inventories	Inventory is stated at the lower of cost and net realizable value. Cost is determined using the first-in, first-out method. Inventory consisted of the following: June 30, December 31, (In thousands) 2022 2021 Raw materials $ 52,870 $ 56,125 Work in process 70,437 59,105 Finished goods ( 1) 32,301 35,105 Total inventory $ 155,608 $ 150,335 (1) At June 30, 2022 and December 31, 2021, the Company had $25.7 million and $25.1 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

Property, Plant and Equipment (

Property, Plant and Equipment (Tables)	6 Months Ended
	Jun. 30, 2022
Property Plant And Equipment [Abstract]
Schedule of Property, Plant and Equipment	Property, plant and equipment consisted of the following: June 30, December 31, (In thousands) 2022 2021 Land $ 6,560 $ 6,560 Building and improvements 193,914 192,920 Furniture, fixtures and equipment 406,868 398,099 Leasehold improvements 52,526 52,526 Construction in progress 92,839 86,512 Subtotal 752,707 736,617 Less: accumulated depreciation (415,561 ) (395,563 ) Total property, plant and equipment, net $ 337,146 $ 341,054

Goodwill and Intangible Assets

Goodwill and Intangible Assets (Tables)	6 Months Ended
	Jun. 30, 2022
Goodwill And Intangible Assets Disclosure [Abstract]
Schedule of Goodwill and Intangible Assets	Goodwill and intangible assets consisted of the following: June 30, 2022 (In thousands) Weighted Amortizable Life (Years) Gross Carrying Amount Accumulated Amortization Net Carrying Amount Goodwill $ 92,873 $ — $ 92,873 Finite-lived intangible assets: Collaboration agreements 12 $ 465,590 $ (421,331 ) $ 44,259 Capitalized IP 11-13 118,160 (106,408 ) 11,752 Total $ 583,750 $ (527,739 ) $ 56,011

Leases (Tables)

Leases (Tables)	6 Months Ended
	Jun. 30, 2022
Leases [Abstract]
Summary of Future Lease Payments Under Non-Cancelable Leases	Future lease payments under non-cancelable leases at June 30, 2022 and December 31, 2021 consisted of the following: June 30, December 31, (In thousands) 2022 2021 2022 $ 9,012 $ 17,991 2023 18,206 17,329 2024 18,476 17,535 2025 18,750 17,808 2026 14,719 13,777 Thereafter 95,289 95,229 Total operating lease payments $ 174,452 $ 179,669 Less: imputed interest (58,676 ) (59,267 ) Total operating lease liabilities $ 115,776 $ 120,402

Accounts Payable and Accrued _2

Accounts Payable and Accrued Expenses (Tables)	6 Months Ended
	Jun. 30, 2022
Payables And Accruals [Abstract]
Schedule of Accounts Payable and Accrued Expenses	Accounts payable and accrued expenses consisted of the following: June 30, December 31, (In thousands) 2022 2021 Accounts payable $ 40,047 $ 55,721 Accrued compensation 52,865 77,256 Accrued other 93,902 75,514 Total accounts payable and accrued expenses $ 186,814 $ 208,491
Summary of Current Provision for Sales, Discounts, Allowances and Reserves	A summary of the Company’s current provision for sales discounts, allowances and reserves is as follows: June 30, December 31, (In thousands) 2022 2021 Medicaid rebates $ 191,458 $ 195,413 Product discounts 13,956 14,951 Medicare Part D 13,087 14,348 Other 10,472 12,504 Total accrued sales discounts, allowances and reserves $ 228,973 $ 237,216

Long-term Debt (Tables)

Long-term Debt (Tables)	6 Months Ended
	Jun. 30, 2022
Debt Disclosure [Abstract]
Schedule of Long-term Debt	Long-term debt consisted of the following: June 30, December 31, (In thousands) 2022 2021 2026 Term Loans, due March 12, 2026 $ 294,537 $ 295,804 Less: current portion (3,000 ) (3,000 ) Long-term debt $ 291,537 $ 292,804

Share-based Compensation (Table

Share-based Compensation (Tables)	6 Months Ended
	Jun. 30, 2022
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Schedule of Share-based Compensation Expense	The following table presents share-based compensation expense included in the accompanying condensed consolidated statements of operations and comprehensive (loss) income: Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Cost of goods manufactured and sold $ 2,401 $ 2,683 $ 4,783 $ 4,861 Research and development 7,222 7,131 12,830 11,194 Selling, general and administrative 13,754 17,738 24,107 26,948 Total share-based compensation expense $ 23,377 $ 27,552 $ 41,720 $ 43,003

(Loss) Earnings Per Share (Tabl

(Loss) Earnings Per Share (Tables)	6 Months Ended
	Jun. 30, 2022
Earnings Per Share [Abstract]
Schedule of Basic (Loss) Earnings Per Ordinary Share	Basic (loss) earnings per ordinary share is calculated based upon net (loss) income available to holders of ordinary shares divided by the weighted average number of ordinary shares outstanding. For the calculation of diluted (loss) earnings per ordinary share, the Company adjusts the weighted average number of ordinary shares outstanding for the effect of outstanding ordinary share equivalents such as stock options and restricted stock unit awards. Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Numerator: Net (loss) income $ (30,136 ) $ 2,364 $ (66,039 ) $ (20,054 ) Denominator: Weighted average number of ordinary shares outstanding 163,839 160,817 163,165 160,229 Effect of dilutive securities: Stock options — 461 — — Restricted stock unit awards — 2,659 — — Dilutive ordinary share equivalents — 3,120 — — Shares used in calculating diluted (loss) earnings per share 163,839 163,937 163,165 160,229
Schedule of Anti-Dilutive Outstanding Common Share Equivalent Excluded from Calculation of Net (Loss) Earnings Per Share	The following outstanding ordinary share equivalents were not included in the net (loss) earnings per ordinary share calculation because the effect would have been anti-dilutive: Three Months Ended Six Months Ended June 30, June 30, (In thousands) 2022 2021 2022 2021 Stock options 12,781 15,465 12,677 15,265 Restricted stock unit awards 4,718 596 6,251 3,189 Total 17,499 16,061 18,928 18,454

Summary of Significant Accoun_3

Summary of Significant Accounting Policies - Additional Information (Details)	6 Months Ended
	Jun. 30, 2022 segment
Accounting Policies [Abstract]
Number of business segments	1

Revenue from Contracts with C_3

Revenue from Contracts with Customers - Schedule of Disaggregation of Revenue (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation Of Revenue [Line Items]
Total revenues	$ 276,219	$ 303,717	$ 554,764	$ 555,147
VIVITROL
Disaggregation Of Revenue [Line Items]
Total revenues	96,105	88,417	180,959	162,951
ARISTADA and ARISTADA INITIO
Disaggregation Of Revenue [Line Items]
Total revenues	74,622	72,391	147,107	127,820
LYBALVI
Disaggregation Of Revenue [Line Items]
Total revenues	20,060		33,989
Product sales, net
Disaggregation Of Revenue [Line Items]
Total revenues	$ 190,787	$ 160,808	$ 362,055	$ 290,771

Revenue from Contracts with C_4

Revenue from Contracts with Customers - Schedule of Manufacturing and Royalty Revenues (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Disaggregation Of Revenue [Line Items]
Total revenues	$ 276,219	$ 303,717	$ 554,764	$ 555,147
Manufacturing Revenue
Disaggregation Of Revenue [Line Items]
Total revenues	25,574	29,293	64,401	54,378
Manufacturing Revenue | VUMERITY
Disaggregation Of Revenue [Line Items]
Total revenues	5,650	6,724	17,045	9,172
Manufacturing Revenue | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	8,571	12,003	24,149	22,686
Manufacturing Revenue | Other
Disaggregation Of Revenue [Line Items]
Total revenues	11,353	10,566	23,207	22,520
Royalty
Disaggregation Of Revenue [Line Items]
Total revenues	59,752	113,001	126,095	207,763
Royalty | Long-Acting INVEGA Products
Disaggregation Of Revenue [Line Items]
Total revenues	26,648	81,072	63,702	142,642
Royalty | VUMERITY
Disaggregation Of Revenue [Line Items]
Total revenues	20,520	13,624	39,720	24,616
Royalty | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	1,820	2,448	3,668	5,927
Royalty | Other
Disaggregation Of Revenue [Line Items]
Total revenues	10,764	15,857	19,005	34,578
Manufacturing and royalty revenues
Disaggregation Of Revenue [Line Items]
Total revenues	85,326	142,294	190,496	262,141
Manufacturing and royalty revenues | Long-Acting INVEGA Products
Disaggregation Of Revenue [Line Items]
Total revenues	26,648	81,072	63,702	142,642
Manufacturing and royalty revenues | VUMERITY
Disaggregation Of Revenue [Line Items]
Total revenues	26,170	20,348	56,765	33,788
Manufacturing and royalty revenues | RISPERDAL CONSTA
Disaggregation Of Revenue [Line Items]
Total revenues	10,391	14,451	27,817	28,613
Manufacturing and royalty revenues | Other
Disaggregation Of Revenue [Line Items]
Total revenues	$ 22,117	$ 26,423	$ 42,212	$ 57,098

Revenue from Contracts with C_5

Revenue from Contracts with Customers - Additional Information (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Disaggregation Of Revenue [Line Items]
Contract assets	$ 16,486	$ 13,363
Contract liabilities	13,759	17,830
Contract liabilities–short-term
Disaggregation Of Revenue [Line Items]
Contract liabilities	3,800	6,300
Other long-term liabilities
Disaggregation Of Revenue [Line Items]
Contract liabilities	10,000	$ 11,500
VUMERITY | Biogen
Disaggregation Of Revenue [Line Items]
Contract assets	$ 5,000
Consideration expected to receive year	2022-11
Minimum
Disaggregation Of Revenue [Line Items]
Manufacturing Process period	10 days
Maximum
Disaggregation Of Revenue [Line Items]
Manufacturing Process period	56 days

Revenue from Contracts with C_6

Revenue from Contracts with Customers - Schedule of Contract Assets and Contract Liabilities (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Contract Asset [Abstract]
Contract assets at beginning of period	$ 13,363
Additions	21,883
Transferred to receivables, net	(18,760)
Contract assets at end of period	16,486
Contract Liabilities [Abstract]
Contract liabilities at beginning of the period	17,830
Additions	829
Amounts recognized into revenue	(4,900)
Contract liabilities at end of the period	$ 13,759

Investments - Schedule of Inves

Investments - Schedule of Investments (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Available-for-sale securities:
Amortized Cost	$ 512,540
Estimated Fair Value	503,511
Held-to-maturity securities:
Estimated Fair Value	1,820
Long-term Investments
Amortized Cost	184,845	$ 230,811
Gross Unrealized Losses, Less than One Year	(5,563)	(1,381)
Gross Unrealized Losses, Greater than One Year	(272)
Total long-term investments	179,010	229,430
Total investments
Amortized Cost	514,360	429,407
Gross Unrealized Gains	26	287
Gross Unrealized Losses, Less than One Year	(8,720)	(1,497)
Gross Unrealized Losses, Greater than One Year	(335)
Estimated Fair Value	505,331	428,197
Short-term investments
Available-for-sale securities:
Amortized Cost	329,515	198,596
Gross Unrealized Gains	26	287
Gross Unrealized Losses, Less than One Year	(3,157)	(116)
Gross Unrealized Losses, Greater than One Year	(63)
Estimated Fair Value	326,321	198,767
Short-term investments | Corporate debt securities
Available-for-sale securities:
Amortized Cost	146,785	85,201
Gross Unrealized Gains	4	177
Gross Unrealized Losses, Less than One Year	(1,744)	(39)
Estimated Fair Value	145,045	85,339
Short-term investments | U.S. government and agency debt securities
Available-for-sale securities:
Amortized Cost	117,944	45,349
Gross Unrealized Gains	22	35
Gross Unrealized Losses, Less than One Year	(909)	(24)
Estimated Fair Value	117,057	45,360
Short-term investments | Non-U.S. government debt securities
Available-for-sale securities:
Amortized Cost	64,786	68,046
Gross Unrealized Gains		75
Gross Unrealized Losses, Less than One Year	(504)	(53)
Gross Unrealized Losses, Greater than One Year	(63)
Estimated Fair Value	64,219	68,068
Long-term investments
Available-for-sale securities:
Amortized Cost	183,025	228,991
Gross Unrealized Losses, Less than One Year	(5,563)	(1,381)
Gross Unrealized Losses, Greater than One Year	(272)
Estimated Fair Value	177,190	227,610
Long-term investments | Certificates of deposit
Held-to-maturity securities:
Amortized Cost	1,820	1,820
Estimated Fair Value	1,820	1,820
Long-term investments | Corporate debt securities
Available-for-sale securities:
Amortized Cost	94,346	111,793
Gross Unrealized Losses, Less than One Year	(2,806)	(654)
Gross Unrealized Losses, Greater than One Year	(48)
Estimated Fair Value	91,492	111,139
Long-term investments | U.S. government and agency debt securities
Available-for-sale securities:
Amortized Cost	73,000	81,296
Gross Unrealized Losses, Less than One Year	(2,364)	(517)
Gross Unrealized Losses, Greater than One Year	(50)
Estimated Fair Value	70,586	80,779
Long-term investments | Non-U.S. government debt securities
Available-for-sale securities:
Amortized Cost	15,679	35,902
Gross Unrealized Losses, Less than One Year	(393)	(210)
Gross Unrealized Losses, Greater than One Year	(174)
Estimated Fair Value	$ 15,112	$ 35,692

Investments - Additional Inform

Investments - Additional Information (Details) € in Millions	1 Months Ended	3 Months Ended			6 Months Ended	12 Months Ended
	Jan. 31, 2022 USD ($)	Jun. 30, 2022 USD ($)	Mar. 31, 2022 USD ($) Portfolio	Jun. 30, 2021 USD ($)	Jun. 30, 2022 USD ($)	Dec. 31, 2021 USD ($)	Jun. 30, 2022 EUR (€)
Investment Holdings [Line Items]
Aggregate estimated fair value of investments in unrealized loss position		$ 492,100,000			$ 492,100,000
Return of Fountain Healthcare Partners II, L.P. investment					$ 485,000
Synchronicity Pharma Inc | Investee | Maximum
Investment Holdings [Line Items]
Equity method investment percentage	50%
Synchronicity Pharma Inc | Convertible Promissory Notes | Investee
Investment Holdings [Line Items]
Purchase of convertible promissory notes	$ 500,000
Convertible promissory notes, maturity date	Sep. 30, 2022
Fountain Healthcare Partners II
Investment Holdings [Line Items]
Funding commitment as percentage of partnership's total funding		7%			7%		7%
Equity method commitment | €							€ 8
Number of portfolio sold | Portfolio			1
Proceeds from sale of portfolio			$ 1,000,000			$ 1,100,000
Escrow deposit			100,000
Gain (loss) on sale of investment		$ 1,100,000			$ 1,100,000
Return of Fountain Healthcare Partners II, L.P. investment			500,000
Fountain Healthcare Partners II | Other Assets
Investment Holdings [Line Items]
Carrying value of equity investment		$ 6,700,000			$ 6,700,000	$ 6,100,000
Other Income (Expense), Net
Investment Holdings [Line Items]
Other-than-temporary impairment charge				$ 900,000
Other Expense, Net | Fountain Healthcare Partners II
Investment Holdings [Line Items]
Gain (loss) on sale of investment			$ 600,000

Investments - Schedule of Proce

Investments - Schedule of Proceeds from Sales and Maturities of Marketable Securities Plus Resulting Realized Gains and Losses (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Investments Debt And Equity Securities [Abstract]
Sales and maturities of investments	$ 109,925	$ 175,499
Realized losses		$ 977

Investments - Schedule of Contr

Investments - Schedule of Contractual Maturities of Available-for-Sale and Held-to-Maturity Securities (Details) $ in Thousands	Jun. 30, 2022 USD ($)
Available-for-sale, Amortized Cost
Within 1 year	$ 326,560
After 1 year through 5 years	185,980
Amortized Cost	512,540
Available-for-sale, Estimated Fair Value
Within 1 year	323,341
After 1 year through 5 years	180,170
Total	503,511
Held-to-maturity, Amortized Cost
Within 1 year	1,820
Total	1,820
Held-to-maturity, Estimated Fair Value
Within 1 year	1,820
Total	$ 1,820

Fair Value - Summary of the Com

Fair Value - Summary of the Company's Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Fair value
Debt securities	$ 503,511
Contingent consideration	3,800	$ 23,000
Recurring Basis
Fair value
Cash equivalents	14,980
Contingent consideration	3,779	23,048
Assets, Total	522,270	449,425
Recurring Basis | Level 1
Fair value
Cash equivalents	14,980
Assets, Total	168,462	96,597
Recurring Basis | Level 2
Fair value
Assets, Total	349,529	329,780
Recurring Basis | Level 3
Fair value
Contingent consideration	3,779	23,048
Assets, Total	4,279	23,048
U.S. government and agency debt securities | Recurring Basis
Fair value
Debt securities	187,643	126,139
U.S. government and agency debt securities | Recurring Basis | Level 1
Fair value
Debt securities	153,482	96,597
U.S. government and agency debt securities | Recurring Basis | Level 2
Fair value
Debt securities	34,161	29,542
Corporate debt securities | Recurring Basis
Fair value
Debt securities	236,537	196,478
Corporate debt securities | Recurring Basis | Level 2
Fair value
Debt securities	236,037	196,478
Corporate debt securities | Recurring Basis | Level 3
Fair value
Debt securities	500
Non-U.S. government debt securities | Recurring Basis
Fair value
Debt securities	79,331	103,760
Non-U.S. government debt securities | Recurring Basis | Level 2
Fair value
Debt securities	$ 79,331	$ 103,760

Fair Value - Additional Informa

Fair Value - Additional Information (Details)	3 Months Ended	6 Months Ended	12 Months Ended
	Mar. 31, 2022 USD ($)	Jun. 30, 2022 USD ($) Installment	Dec. 31, 2021 USD ($)
Fair Value
Transfers between Level 1 to Level 2		$ 0
Transfers between Level 2 to Level 1		0
Milestone payments received			$ 7,800,000
Milestone payment receivable		$ 38,600,000
Number of equal annual installments milestone payment | Installment		6
Contingent consideration		$ 3,800,000	23,000,000
Contingent consideration included within prepaid expenses and other current assets		3,800,000	6,400,000
Contingent consideration included within other assets		0	16,600,000
2026 Term Loans
Fair Value
Amount to be realized in future		277,700,000	$ 285,800,000
Baudax
Fair Value
Milestone payments received		1,000,000
Milestone payment receivable	$ 6,400,000	$ 6,400,000
Percentage of reduction in workforce planned	80%
Weighting percentage of default on obligations		100%
Percentage of discount recovery rate		9%
Baudax | Maximum
Fair Value
Milestone payment receivable		$ 80,000,000

Fair Value - Rollforward of the

Fair Value - Rollforward of the Fair Value of the Assets Determined using Level 3 Inputs (Details) $ in Thousands	6 Months Ended
	Jun. 30, 2022 USD ($)
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Balance at the beginning of the period	$ 23,048
Purchase of corporate debt security	500
Milestone and royalty payments received by the Company related to contingent consideration	(1,043)
Royalty payments due to the Company related to contingent consideration	(29)
Balance at the end of the period	4,279
Change In The Fair Value Of Contingent Consideration
Roll forward of the fair value of the Company's investments whose fair value was determined using Level 3 inputs
Change in the fair value	$ (18,197)

Inventory - Schedule of Invento

Inventory - Schedule of Inventories (Details) - USD ($) $ in Thousands		Jun. 30, 2022	Dec. 31, 2021
Inventory Disclosure [Abstract]
Raw materials		$ 52,870	$ 56,125
Work in process		70,437	59,105
Finished goods	[1]	32,301	35,105
Total inventory		$ 155,608	$ 150,335
[1] At June 30, 2022 and December 31, 2021, the Company had $25.7 million and $25.1 million, respectively, of finished goods inventory located at its third-party warehouse and shipping service provider.

Inventory - Schedule of Inven_2

Inventory - Schedule of Inventories (Parenthetical) (Details) - USD ($) $ in Millions	Jun. 30, 2022	Dec. 31, 2021
Inventory Disclosure [Abstract]
Finished goods inventory located at third-party warehouse and shipping service provider	$ 25.7	$ 25.1

Property, Plant and Equipment -

Property, Plant and Equipment - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Property, plant and equipment
Property, plant and equipment, gross	$ 752,707	$ 736,617
Less: accumulated depreciation	(415,561)	(395,563)
Total property, plant and equipment, net	337,146	341,054
Land
Property, plant and equipment
Property, plant and equipment, gross	6,560	6,560
Building and Improvements
Property, plant and equipment
Property, plant and equipment, gross	193,914	192,920
Furniture, Fixtures and Equipment
Property, plant and equipment
Property, plant and equipment, gross	406,868	398,099
Leasehold Improvements
Property, plant and equipment
Property, plant and equipment, gross	52,526	52,526
Construction in Progress
Property, plant and equipment
Property, plant and equipment, gross	$ 92,839	$ 86,512

Goodwill and Intangible Asset_2

Goodwill and Intangible Assets - Schedule of Goodwill and Intangible Assets (Details) - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Goodwill
Gross Carrying Amount	$ 92,873
Net Carrying Amount	92,873	$ 92,873
Finite-lived intangible assets:
Gross Carrying Amount	583,750
Accumulated Amortization	(527,739)
Net Carrying Amount	$ 56,011	$ 74,043
Collaboration agreements
Finite-lived intangible assets:
Weighted Amortizable Life	12 years
Gross Carrying Amount	$ 465,590
Accumulated Amortization	(421,331)
Net Carrying Amount	44,259
Capitalized IP
Finite-lived intangible assets:
Gross Carrying Amount	118,160
Accumulated Amortization	(106,408)
Net Carrying Amount	$ 11,752
Capitalized IP | Minimum
Finite-lived intangible assets:
Weighted Amortizable Life	11 years
Capitalized IP | Maximum
Finite-lived intangible assets:
Weighted Amortizable Life	13 years

Goodwill and Intangible Asset_3

Goodwill and Intangible Assets - Additional Information (Details) $ in Millions	Jun. 30, 2022 USD ($)
Expected amortization of intangible assets
2022	$ 35
2023	35
2024	$ 1

Leases - Summary of Future Leas

Leases - Summary of Future Lease Payments Under Non-Cancelable Leases (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Leases [Abstract]
Remainder of fiscal year	$ 9,012
Year 1	18,206	$ 17,991
Year 2	18,476	17,329
Year 3	18,750	17,535
Year 4	14,719	17,808
Year 5		13,777
Thereafter		95,229
Thereafter	95,289
Total operating lease payments	174,452	179,669
Less: imputed interest	(58,676)	(59,267)
Total operating lease liabilities	$ 115,776	$ 120,402

Leases - Additional Information

Leases - Additional Information (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Leases [Abstract]
Weighted average incremental borrowing rate	5.21%		5.21%
Payments for operating leases	$ 4.5	$ 4.4	$ 8.9	$ 8.1
Weighted average remaining lease term	11 years 1 month 6 days		11 years 1 month 6 days
Operating lease expense	$ 4.2	$ 4.4	$ 8.3	$ 8.6

Accounts Payable and Accrued _3

Accounts Payable and Accrued Expenses - Schedule of Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Payables And Accruals [Abstract]
Accounts payable	$ 40,047	$ 55,721
Accrued compensation	52,865	77,256
Accrued other	93,902	75,514
Total accounts payable and accrued expenses	$ 186,814	$ 208,491

Accounts Payable and Accrued _4

Accounts Payable and Accrued Expenses - Summary of Current Provision for Sales, Discounts, Allowances and Reserves (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accounts Payable And Accrued Expenses [Line Items]
Total accrued sales discounts, allowances and reserves	$ 228,973	$ 237,216
Medicaid Rebate
Accounts Payable And Accrued Expenses [Line Items]
Total accrued sales discounts, allowances and reserves	191,458	195,413
Product Discounts
Accounts Payable And Accrued Expenses [Line Items]
Total accrued sales discounts, allowances and reserves	13,956	14,951
Medicare Part D
Accounts Payable And Accrued Expenses [Line Items]
Total accrued sales discounts, allowances and reserves	13,087	14,348
Other
Accounts Payable And Accrued Expenses [Line Items]
Total accrued sales discounts, allowances and reserves	$ 10,472	$ 12,504

Long-term Debt - Schedule of Lo

Long-term Debt - Schedule of Long-term Debt (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Long-term debt
Less: current portion	$ (3,000)	$ (3,000)
Long-term debt	291,537	292,804
2026 Term Loans, due March 12, 2026
Long-term debt
Term Loans	294,537	295,804
Less: current portion	(3,000)	(3,000)
Long-term debt	$ 291,537	$ 292,804

Long-term Debt - Additional Inf

Long-term Debt - Additional Information (Details) - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Interest Expense
Long-term debt
Refinancing charges		$ 2.1
2026 Term Loans
Long-term debt
Due date of loan	Mar. 12, 2026
Variable interest rate base	LIBOR
Incremental capacity	$ 175
2026 Term Loans | LIBOR
Long-term debt
Interest rate added to base rate (as a percent)	2.50%
Interest rate, variable interest rate floor (as a percent)	0.50%

Share-based Compensation - Sche

Share-based Compensation - Schedule of Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Share-based compensation Expense
Total share-based compensation expense	$ 23,377	$ 27,552	$ 41,720	$ 43,003
Cost of goods manufactured and sold
Share-based compensation Expense
Total share-based compensation expense	2,401	2,683	4,783	4,861
Research and development
Share-based compensation Expense
Total share-based compensation expense	7,222	7,131	12,830	11,194
Selling, general and administrative
Share-based compensation Expense
Total share-based compensation expense	$ 13,754	$ 17,738	$ 24,107	$ 26,948

Share-based Compensation - Addi

Share-based Compensation - Additional Information (Details) - USD ($) $ in Millions	6 Months Ended	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share based compensation cost capitalized	$ 2.8	$ 2.3

(Loss) Earnings Per Share - Sch

(Loss) Earnings Per Share - Schedule of Basic (Loss) Earnings Per Ordinary Share (Details) - USD ($) shares in Thousands, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Net (loss) income	$ (30,136)	$ (35,903)	$ 2,364	$ (22,418)	$ (66,039)	$ (20,054)
Basic	163,839		160,817		163,165	160,229
Effect of dilutive securities:
Dilutive ordinary share equivalents			3,120
Shares used in calculating diluted (loss) earnings per share	163,839		163,937		163,165	160,229
Stock Options
Effect of dilutive securities:
Dilutive effect of securities			461
Restricted Stock Unit Awards
Effect of dilutive securities:
Dilutive effect of securities			2,659

(Loss) Earnings Per Share - S_2

(Loss) Earnings Per Share - Schedule of Anti-Dilutive Outstanding Common Share Equivalent Excluded from Calculation of Net (Loss) Earnings Per Share (Details) - shares shares in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Denominator:
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share	17,499	16,061	18,928	18,454
Stock Options
Denominator:
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share	12,781	15,465	12,677	15,265
Restricted Stock Unit Awards
Denominator:
Anti-dilutive potential common share equivalent excluded from calculation of net loss per ordinary share	4,718	596	6,251	3,189

Income Taxes - Additional Infor

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Income Tax Disclosure [Abstract]
Income tax benefits	$ 3,114	$ (3,291)	$ 12,209	$ (7,056)

Commitments and Contingent Li_2

Commitments and Contingent Liabilities - Additional Information (Details)	1 Months Ended	6 Months Ended
	Sep. 30, 2020	Jun. 30, 2022 USD ($) Agreement
Commitments And Contingencies [Line Items]
Potential material losses from claims, legal proceedings probable of occurring | $		$ 0
Maximum number of months before FDA can approve patent request	30 months
Janssen Pharmaceutica N.V.
Commitments And Contingencies [Line Items]
Number of license agreements partially terminated | Agreement		2