| Document and Entity Information | Jan. 05, 2024 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Jan. 05, 2024 |
| Entity Registrant Name | Personalis, Inc. |
| Entity Central Index Key | 0001527753 |
| Entity Emerging Growth Company | false |
| Entity File Number | 001-38943 |
| Entity Incorporation State Country Code | DE |
| Entity Tax Identification Number | 27-5411038 |
| Entity Address, Address Line One | 6600 Dumbarton Circle |
| Entity Address, City or Town | Fremont |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 94555 |
| City Area Code | 650 |
| Local Phone Number | 752-1300 |
| Written Communications | false |
| Soliciting Material | false |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.0001 par value per share |
| Trading Symbol | PSNL |
| Security Exchange Name | NASDAQ |
