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Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
RXi Pharmaceuticals Corporation
Westborough, Massachusetts
We hereby consent to the incorporation by reference in the Registration Statement on Form S-8 (No. 333-183633) of RXi Pharmaceuticals Corporation of our report dated March 28, 2014, relating to the financial statements, which appear in this
Form 10-K.
/s/ BDO USA, LLP
Boston, Massachusetts
March 28, 2014