| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 1847 GOEDEKER INC | COM | 28252C109 | 948 | 301,751 | SH | | DFND | 1 | 0 | 301,751 | 0 |
| 1847 GOEDEKER INC | COM | 28252C959 | 2,140 | 6,816 | SH | Put | DFND | 1 | 0 | 6,816 | 0 |
| 9 METERS BIOPHARMA INC | COM | 654405909 | 475 | 3,655 | SH | Call | DFND | 1 | 0 | 3,655 | 0 |
| 9 METERS BIOPHARMA INC | COM | 654405959 | 3,168 | 24,371 | SH | Put | DFND | 1 | 0 | 24,371 | 0 |
| ABVC BIOPHARMA INC | COM | 00091F106 | 165 | 71,558 | SH | | DFND | 1 | 0 | 71,558 | 0 |
| ACTINIUM PHARMACEUTICALS INC | COM | 00507W906 | 182 | 205 | SH | Call | DFND | 1 | 0 | 205 | 0 |
| ACTINIUM PHARMACEUTICALS INC | COM | 00507W206 | 235 | 26,488 | SH | | DFND | 1 | 0 | 26,488 | 0 |
| ACTINIUM PHARMACEUTICALS INC | COM | 00507W956 | 3,329 | 3,757 | SH | Put | DFND | 1 | 0 | 3,757 | 0 |
| ACUTUS MED INC | COM | 005111109 | 1,059 | 119,755 | SH | | DFND | 1 | 0 | 119,755 | 0 |
| ADAMIS PHARMACEUTICALS CORP | COM | 00547W908 | 210 | 2,161 | SH | Call | DFND | 1 | 0 | 2,161 | 0 |
| ADAMIS PHARMACEUTICALS CORP | COM | 00547W958 | 293 | 3,024 | SH | Put | DFND | 1 | 0 | 3,024 | 0 |
| ADITXT INC | COM | 007025109 | 208 | 122,863 | SH | | DFND | 1 | 0 | 122,863 | 0 |
| ADITXT INC | COM | 007025959 | 361 | 2,135 | SH | Put | DFND | 1 | 0 | 2,135 | 0 |
| ADOMANI INC | COM | 00726A100 | 232 | 850,000 | SH | | DFND | 1 | 0 | 850,000 | 0 |
| AMARIN CORP PLC | ADR | 023111206 | 759 | 148,771 | SH | | DFND | 1 | 0 | 148,771 | 0 |
| AMARIN CORP PLC | ADR | 023111906 | 4,201 | 8,238 | SH | Call | DFND | 1 | 0 | 8,238 | 0 |
| AMARIN CORP PLC | ADR | 023111956 | 2,102 | 4,122 | SH | Put | DFND | 1 | 0 | 4,122 | 0 |
| AMPLITECH GROUP INC | COM | 03211Q200 | 1,093 | 305,255 | SH | | DFND | 1 | 0 | 305,255 | 0 |
| AMPLITECH GROUP INC | *W | 03211Q119 | 453 | 348,673 | SH | | DFND | 1 | 0 | 348,673 | 0 |
| ARCADIA BIOSCIENCES INC | COM | 039014954 | 684 | 3,304 | SH | Put | DFND | 1 | 0 | 3,304 | 0 |
| ASLAN PHARMACEUTICALS LTD | ADS | 04522R101 | 1,225 | 688,400 | SH | | DFND | 1 | 0 | 688,400 | 0 |
| ASLAN PHARMACEUTICALS LTD | ADS | 04522R951 | 54 | 304 | SH | Put | DFND | 1 | 0 | 304 | 0 |
| ATERIAN INC | COM | 02156U951 | 1,404 | 1,296 | SH | Put | DFND | 1 | 0 | 1,296 | 0 |
| ATHERSYS INC NEW | COM | 04744L956 | 41 | 307 | SH | Put | DFND | 1 | 0 | 307 | 0 |
| ATHERSYS INC NEW | COM | 04744L106 | 155 | 116,444 | SH | | DFND | 1 | 0 | 116,444 | 0 |
| ATHERSYS INC NEW | COM | 04744L906 | 881 | 6,621 | SH | Call | DFND | 1 | 0 | 6,621 | 0 |
| ATOSSA THERAPEUTICS INC | COM | 04962H906 | 713 | 2,187 | SH | Call | DFND | 1 | 0 | 2,187 | 0 |
| ATOSSA THERAPEUTICS INC | COM | 04962H956 | 5,126 | 15,725 | SH | Put | DFND | 1 | 0 | 15,725 | 0 |
| AURINIA PHARMACEUTICALS INC | COM | 05156V902 | 1,038 | 469 | SH | Call | DFND | 1 | 0 | 469 | 0 |
| AUTOLUS THERAPEUTICS LTD | ADS | 05280R900 | 268 | 409 | SH | Call | DFND | 1 | 0 | 409 | 0 |
| AUTOLUS THERAPEUTICS LTD | ADS | 05280R100 | 1,965 | 300,000 | SH | | DFND | 1 | 0 | 300,000 | 0 |
| BARCLAYS BANK PLC | IPTH | 06747R477 | 11,132 | 400,000 | SH | | DFND | 1 | 0 | 400,000 | 0 |
| BARCLAYS BANK PLC | IPTH | 06747R907 | 14,850 | 5,336 | SH | Call | DFND | 1 | 0 | 5,336 | 0 |
| BIO-KEY INTL INC | COM | 09060C408 | 70 | 20,001 | SH | | DFND | 1 | 0 | 20,001 | 0 |
| BIO-KEY INTL INC | COM | 09060C958 | 571 | 1,623 | SH | Put | DFND | 1 | 0 | 1,623 | 0 |
| BIOPHYTIS SA | ADS | 09076G104 | 893 | 103,263 | SH | | DFND | 1 | 0 | 103,263 | 0 |
| BIOVIE INC | CL A | 09074F207 | 3,378 | 504,861 | SH | | DFND | 1 | 0 | 504,861 | 0 |
| BIT DIGITAL INC | SHS | G1144A955 | 4,039 | 5,586 | SH | Put | DFND | 1 | 0 | 5,586 | 0 |
| BIT DIGITAL INC | SHS | G1144A105 | 30,484 | 4,216,310 | SH | | DFND | 1 | 0 | 4,216,310 | 0 |
| BIT MINING LTD | ADR | 055474950 | 2,336 | 2,859 | SH | Put | DFND | 1 | 0 | 2,859 | 0 |
| BIT MINING LTD | ADR | 055474100 | 16,340 | 2,000,000 | SH | | DFND | 1 | 0 | 2,000,000 | 0 |
| BRAINSTORM CELL | COM | 10501E201 | 1,572 | 476,325 | SH | | DFND | 1 | 0 | 476,325 | 0 |
| BRAINSTORM CELL | COM | 10501E951 | 1,626 | 4,928 | SH | Put | DFND | 1 | 0 | 4,928 | 0 |
| BUTTERFLY NETWORK INC | COM | 124155902 | 3,657 | 3,503 | SH | Call | DFND | 1 | 0 | 3,503 | 0 |
| CALADRIUS BIOSCIENCES INC | COM | 128058953 | 776 | 6,362 | SH | Put | DFND | 1 | 0 | 6,362 | 0 |
| CALADRIUS BIOSCIENCES INC | COM | 128058203 | 1,164 | 954,235 | SH | | DFND | 1 | 0 | 954,235 | 0 |
| CANAAN INC | ADS | 134748952 | 4,812 | 7,875 | SH | Put | DFND | 1 | 0 | 7,875 | 0 |
| CANAAN INC | ADS | 134748102 | 1,515 | 247,929 | SH | | DFND | 1 | 0 | 247,929 | 0 |
| CARDIFF ONCOLOGY INC | COM | 14147L958 | 113 | 170 | SH | Put | DFND | 1 | 0 | 170 | 0 |
| CASTOR MARITIME INC | SHS | Y1146L955 | 637 | 2,612 | SH | Put | DFND | 1 | 0 | 2,612 | 0 |
| CASTOR MARITIME INC | SHS | Y1146L125 | 666 | 273,130 | SH | | DFND | 1 | 0 | 273,130 | 0 |
| CATALYST BIOSCIENCES INC | COM | 14888D908 | 350 | 852 | SH | Call | DFND | 1 | 0 | 852 | 0 |
| CATALYST BIOSCIENCES INC | COM | 14888D208 | 435 | 105,742 | SH | | DFND | 1 | 0 | 105,742 | 0 |
| CBAK ENERGY TECH INC | COM | 14986C102 | 41 | 17,548 | SH | | DFND | 1 | 0 | 17,548 | 0 |
| CBAK ENERGY TECH INC | COM | 14986C952 | 920 | 3,521 | SH | Put | DFND | 1 | 0 | 3,521 | 0 |
| CITIUS PHARMACEUTICALS INC | COM | 17322U957 | 100 | 491 | SH | Put | DFND | 1 | 0 | 491 | 0 |
| COCRYSTAL PHARMA INC | COM | 19188J300 | 5,424 | 5,165,416 | SH | | DFND | 1 | 0 | 5,165,416 | 0 |
| COLOR STAR TECH CO LTD | SHS | G2287A100 | 3,386 | 6,177,524 | SH | | DFND | 1 | 0 | 6,177,524 | 0 |
| CONTRAFECT CORP | COM | 212326300 | 673 | 166,175 | SH | | DFND | 1 | 0 | 166,175 | 0 |
| CURIS INC | COM | 231269200 | 785 | 100,200 | SH | | DFND | 1 | 0 | 100,200 | 0 |
| CURIS INC | COM | 231269900 | 843 | 1,087 | SH | Call | DFND | 1 | 0 | 1,087 | 0 |
| CYREN LTD | SHS | M26895108 | 1,240 | 2,000,000 | SH | | DFND | 1 | 0 | 2,000,000 | 0 |
| DAXOR CORP | COM | 239467103 | 677 | 57,924 | SH | | DFND | 1 | 0 | 57,924 | 0 |
| DIGINEX LIMITED | SHS | Y2074E959 | 41 | 125 | SH | Put | DFND | 1 | 0 | 125 | 0 |
| DIGINEX LIMITED | SHS | Y2074E109 | 172 | 53,055 | SH | | DFND | 1 | 0 | 53,055 | 0 |
| DIGINEX LTD | SHS | Y2074E959 | 78 | 242 | SH | Put | DFND | 1 | 0 | 242 | 0 |
| DIGINEX LTD | SHS | Y2074E109 | 193 | 59,478 | SH | | DFND | 1 | 0 | 59,478 | 0 |
| DIGITAL ALLY INC | COM | 25382P958 | 1,561 | 12,899 | SH | Put | DFND | 1 | 0 | 12,899 | 0 |
| DIGITAL ALLY INC | COM | 25382P208 | 1,854 | 1,531,958 | SH | | DFND | 1 | 0 | 1,531,958 | 0 |
| ECOARK HOLDINGS INC | COM | 27888N307 | 77 | 14,603 | SH | | DFND | 1 | 0 | 14,603 | 0 |
| EKSO BIONICS HLDGS INC | COM | 282644301 | 1,941 | 420,179 | SH | | DFND | 1 | 0 | 420,179 | 0 |
| ENOCHIAN BIOSCIENCES INC | COM | 29350E104 | 534 | 79,314 | SH | | DFND | 1 | 0 | 79,314 | 0 |
| EVOFEM BIOSCIENCES INCV | COM | 30048L954 | 54 | 725 | SH | Put | DFND | 1 | 0 | 725 | 0 |
| EVOKE PHARMA INC | COM | 30049G104 | 107 | 81,975 | SH | | DFND | 1 | 0 | 81,975 | 0 |
| EXELA TECHS INC | COM | 30162V959 | 983 | 5,067 | SH | Put | DFND | 1 | 0 | 5,067 | 0 |
| FLUX POWER HOLDINGS | COM | 344057302 | 3,317 | 653,016 | SH | | DFND | 1 | 0 | 653,016 | 0 |
| FLUX PWR HLDGS INC | COM | 344057302 | 316 | 62,195 | SH | | DFND | 1 | 0 | 62,195 | 0 |
| FUELCELL ENERGY INC | COM | 35952H901 | 134 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| GLOBUS MARITIME LTD | COM | Y27265956 | 368 | 1,259 | SH | Put | DFND | 1 | 0 | 1,259 | 0 |
| GLOBUS MARITIME LTD | COM | Y27265126 | 1,626 | 556,883 | SH | | DFND | 1 | 0 | 556,883 | 0 |
| GROM SOCIAL ENTERPRISES INC | *W | 39878L118 | 32 | 29,471 | SH | | DFND | 1 | 0 | 29,471 | 0 |
| GUARDFORCE AI CO LTD | *W | G4236L120 | 816 | 1,020,389 | SH | | DFND | 1 | 0 | 1,020,389 | 0 |
| GUARDFORCE AI CO LTD | SHS | G4236L112 | 2,881 | 727,647 | SH | | DFND | 1 | 0 | 727,647 | 0 |
| HARBOR CUSTOM DEVELOPMENT INC | *W | 41150T116 | 83 | 148,975 | SH | | DFND | 1 | 0 | 148,975 | 0 |
| HUMANCO ACQUISITION CORP | *W | 44487N117 | 198 | 200,314 | SH | | DFND | 1 | 0 | 200,314 | 0 |
| HUMANCO ACQUISITION CORP | CL A | 44487N109 | 3,997 | 404,185 | SH | | DFND | 1 | 0 | 404,185 | 0 |
| INFINITY PHARMACEUTICALS | COM | 45665G303 | 241 | 70,431 | SH | | DFND | 1 | 0 | 70,431 | 0 |
| INFINITY PHARMACEUTICALS | COM | 45665G903 | 1,318 | 3,853 | SH | Call | DFND | 1 | 0 | 3,853 | 0 |
| INHIBIKASE THERAPEUTICS INC | COM | 45719W106 | 808 | 425,014 | SH | | DFND | 1 | 0 | 425,014 | 0 |
| INSPIRA TECHNOLOGIES OXY BHN | *W | M53637118 | 208 | 253,063 | SH | | DFND | 1 | 0 | 253,063 | 0 |
| INSPIRA TECHNOLOGIES OXY BHN | SHS | M53637100 | 275 | 102,553 | SH | | DFND | 1 | 0 | 102,553 | 0 |
| ION GEOPHYSICAL CORP | COM | 462044907 | 92 | 692 | SH | Call | DFND | 1 | 0 | 692 | 0 |
| ION GEOPHYSICAL CORP | NOTE | 462044AJ7 | 272,551 | 3,150,000 | PRN | | DFND | 1 | 0 | 3,150,000 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222950 | 2,837 | 846 | SH | Put | DFND | 1 | 0 | 846 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 2,837 | 84,600 | SH | | DFND | 1 | 0 | 84,600 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287905 | 32,813 | 1,500 | SH | Call | DFND | 1 | 0 | 1,500 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 39,244 | 1,794 | SH | Put | DFND | 1 | 0 | 1,794 | 0 |
| IT TECH PACKAGING | COM | 46527C950 | 17 | 254 | SH | Put | DFND | 1 | 0 | 254 | 0 |
| JUPITER WELLNESS INC | COM | 48208F105 | 582 | 412,915 | SH | | DFND | 1 | 0 | 412,915 | 0 |
| KADMON HOLDINGS INC | COM | 48283N106 | 526 | 60,351 | SH | | DFND | 1 | 0 | 60,351 | 0 |
| KANDI TECHNOLOGIES GROUP INC | COM | 483709101 | 1,502 | 337,430 | SH | | DFND | 1 | 0 | 337,430 | 0 |
| KANDI TECHNOLOGIES GROUP INC | COM | 483709951 | 4,335 | 9,742 | SH | Put | DFND | 1 | 0 | 9,742 | 0 |
| KEMPHARM INC | COM | 488445206 | 387 | 41,531 | SH | | DFND | 1 | 0 | 41,531 | 0 |
| KEMPHARM INC | COM | 488445956 | 2,717 | 2,912 | SH | Put | DFND | 1 | 0 | 2,912 | 0 |
| KIROMIC BIOPHARMA INC | COM | 497634105 | 1,468 | 478,122 | SH | | DFND | 1 | 0 | 478,122 | 0 |
| LEXARIA BIOSCIENCE CORP. | *W | 52886N117 | 699 | 332,971 | SH | | DFND | 1 | 0 | 332,971 | 0 |
| MARATHON DIGITAL HOLDINGS INC | COM | 565788106 | 2,294 | 72,643 | SH | | DFND | 1 | 0 | 72,643 | 0 |
| MARATHON DIGITAL HOLDINGS INC | COM | 565788956 | 6,269 | 1,985 | SH | Put | DFND | 1 | 0 | 1,985 | 0 |
| MEATECH 3D LTD | ADS | 583435102 | 443 | 72,700 | SH | | DFND | 1 | 0 | 72,700 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 885 | 5,000 | SH | | DFND | 1 | 0 | 5,000 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T905 | 3,414 | 193 | SH | Call | DFND | 1 | 0 | 193 | 0 |
| MMTEC INC | SHS | G6181K106 | 1,303 | 1,104,286 | SH | | DFND | 1 | 0 | 1,104,286 | 0 |
| MOGO INC | COM | 60800C109 | 1,780 | 412,059 | SH | | DFND | 1 | 0 | 412,059 | 0 |
| MOGO INC | COM | 60800C959 | 2,379 | 5,506 | SH | Put | DFND | 1 | 0 | 5,506 | 0 |
| NABRIVA THERAPEUTICS PLC | COM | G63637113 | 44 | 36,735 | SH | | DFND | 1 | 0 | 36,735 | 0 |
| NABRIVA THERAPEUTICS PLC | COM | G63637953 | 94 | 790 | SH | Put | DFND | 1 | 0 | 790 | 0 |
| NANOVIBRONIX INC | COM | 63008J108 | 21 | 10,000 | SH | | DFND | 1 | 0 | 10,000 | 0 |
| NEMAURA MEDICAL INC | COM | 640442958 | 792 | 1,318 | SH | Put | DFND | 1 | 0 | 1,318 | 0 |
| NEWAGE INC | COM | 650194103 | 3,180 | 2,288,078 | SH | | DFND | 1 | 0 | 2,288,078 | 0 |
| NEWAGE INC | COM | 650194903 | 1,489 | 10,710 | SH | Call | DFND | 1 | 0 | 10,710 | 0 |
| NOVAN INC | COM | 66988N205 | 156 | 19,132 | SH | | DFND | 1 | 0 | 19,132 | 0 |
| NRX PHARMACEUTICALS INC | COM | 629444950 | 858 | 926 | SH | Put | DFND | 1 | 0 | 926 | 0 |
| NUZEE INC | COM | 67073S208 | 1,098 | 499,047 | SH | | DFND | 1 | 0 | 499,047 | 0 |
| OCEAN POWER TECHS | COM | 674870956 | 703 | 3,029 | SH | Put | DFND | 1 | 0 | 3,029 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 | 1,420 | 142,000 | SH | | DFND | 1 | 0 | 142,000 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A900 | 5,115 | 5,115 | SH | Call | DFND | 1 | 0 | 5,115 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A950 | 2,097 | 2,097 | SH | Put | DFND | 1 | 0 | 2,097 | 0 |
| ORAMED PHARMACEUTICALS INC | COM | 68403P203 | 887 | 40,344 | SH | | DFND | 1 | 0 | 40,344 | 0 |
| ORAMED PHARMACEUTICALS INC | COM | 68403P953 | 2,136 | 972 | SH | Put | DFND | 1 | 0 | 972 | 0 |
| ORBITAL ENERGY GROUP INC | COM | 68559A109 | 1,471 | 477,500 | SH | | DFND | 1 | 0 | 477,500 | 0 |
| PAINREFORM LTD | SHS | M77798102 | 326 | 117,528 | SH | | DFND | 1 | 0 | 117,528 | 0 |
| PALISADE BIO INC | COM | 696389105 | 139 | 52,500 | SH | | DFND | 1 | 0 | 52,500 | 0 |
| PDS BIOTECHNOLOGY CORP | COM | 70465T907 | 1,387 | 931 | SH | Call | DFND | 1 | 0 | 931 | 0 |
| PDS BIOTECHNOLOGY CORP | COM | 70465T957 | 423 | 284 | SH | Put | DFND | 1 | 0 | 284 | 0 |
| PHARMACYTE BIOTECH INC | COM | 71715X203 | 3,202 | 1,010,146 | SH | | DFND | 1 | 0 | 1,010,146 | 0 |
| PHARMACYTE BIOTECH INC | COM | 71715X953 | 140 | 441 | SH | Put | DFND | 1 | 0 | 441 | 0 |
| PHIO PHARMACEUTICALS CORP | COM | 71880W303 | 83 | 40,684 | SH | | DFND | 1 | 0 | 40,684 | 0 |
| PHIO PHARMACEUTICALS CORP | COM | 71880W953 | 281 | 1,383 | SH | Put | DFND | 1 | 0 | 1,383 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R950 | 197 | 742 | SH | Put | DFND | 1 | 0 | 742 | 0 |
| PROGENITY INC | COM | 74319F957 | 772 | 5,077 | SH | Put | DFND | 1 | 0 | 5,077 | 0 |
| PURPLE BIOTECH LTD | ADS | 74638P959 | 57 | 125 | SH | Put | DFND | 1 | 0 | 125 | 0 |
| RECON TECHNOLOGY LTD | SHS | G7415M124 | 3,623 | 1,280,097 | SH | | DFND | 1 | 0 | 1,280,097 | 0 |
| RECON TECHNOLOGY LTD | SHS | G7415M954 | 319 | 1,128 | SH | Put | DFND | 1 | 0 | 1,128 | 0 |
| RED CAT HLDGS INC | COM | 75644T100 | 4,731 | 1,359,385 | SH | | DFND | 1 | 0 | 1,359,385 | 0 |
| REWALK ROBOTICS LTD | SHS | M8216Q200 | 2,465 | 1,632,770 | SH | | DFND | 1 | 0 | 1,632,770 | 0 |
| REWALK ROBOTICS LTD | SHS | M8216Q950 | 127 | 839 | SH | Put | DFND | 1 | 0 | 839 | 0 |
| RIOT BLOCKCHAIN INC | COM | 767292105 | 2,083 | 81,052 | SH | | DFND | 1 | 0 | 81,052 | 0 |
| RIOT BLOCKCHAIN INC | COM | 767292955 | 2,619 | 1,019 | SH | Put | DFND | 1 | 0 | 1,019 | 0 |
| SECOND SIGHT MEDICAL PRODS INC | COM | 81362J209 | 931 | 291,973 | SH | | DFND | 1 | 0 | 291,973 | 0 |
| SECOND SIGHT MEDICAL PRODS INC | COM | 81362J959 | 680 | 2,132 | SH | Put | DFND | 1 | 0 | 2,132 | 0 |
| SORRENTO THERAPEUTICS | COM | 83587F202 | 12,957 | 1,698,107 | SH | | DFND | 1 | 0 | 1,698,107 | 0 |
| SORRENTO THERAPEUTICS | COM | 83587F952 | 16,669 | 21,846 | SH | Put | DFND | 1 | 0 | 21,846 | 0 |
| SPDR S&P 500 ETF TR | ETF | 78462F903 | 32,186 | 750 | SH | Call | DFND | 1 | 0 | 750 | 0 |
| SPDR S&P 500 ETF TR | ETF | 78462F953 | 19,054 | 444 | SH | Put | DFND | 1 | 0 | 444 | 0 |
| SPDR SERIES TRUST | ETF | 78464A870 | 440 | 3,500 | SH | | DFND | 1 | 0 | 3,500 | 0 |
| SPDR SERIES TRUST | ETF | 78464A950 | 21,534 | 1,713 | SH | Put | DFND | 1 | 0 | 1,713 | 0 |
| SPHERE 3D CORP | COM | 84841L958 | 3,018 | 5,081 | SH | Put | DFND | 1 | 0 | 5,081 | 0 |
| SPI ENERGY CO LTD | SHS | G8651P950 | 1,571 | 3,130 | SH | Put | DFND | 1 | 0 | 3,130 | 0 |
| SPLASH BEVERAGE GROUP INC | *W | 84862C112 | 321 | 605,659 | SH | | DFND | 1 | 0 | 605,659 | 0 |
| STATERA BIOPHARMA INC | COM | 857561104 | 847 | 366,460 | SH | | DFND | 1 | 0 | 366,460 | 0 |
| SURGALIGN HOLDINGS INC | COM | 86882C105 | 35 | 31,927 | SH | | DFND | 1 | 0 | 31,927 | 0 |
| SURGALIGN HOLDINGS INC | COM | 86882C955 | 193 | 1,773 | SH | Put | DFND | 1 | 0 | 1,773 | 0 |
| TAKUNG ART LTD | COM | 87407Q207 | 4,620 | 608,740 | SH | | DFND | 1 | 0 | 608,740 | 0 |
| TANZANIAN GOLD CORP | COM | 87601A107 | 6 | 12,213 | SH | | DFND | 1 | 0 | 12,213 | 0 |
| TANZANIAN GOLD CORP | COM | 87601A957 | 20 | 404 | SH | Put | DFND | 1 | 0 | 404 | 0 |
| THE9 LTD | ADS | 88337K302 | 543 | 52,691 | SH | | DFND | 1 | 0 | 52,691 | 0 |
| THE9 LTD | ADS | 88337K902 | 297 | 288 | SH | Call | DFND | 1 | 0 | 288 | 0 |
| THE9 LTD | ADS | 88337K952 | 2,330 | 2,260 | SH | Put | DFND | 1 | 0 | 2,260 | 0 |
| TITAN PHARMACEUTICALS INC | COM | 888314956 | 34 | 184 | SH | Put | DFND | 1 | 0 | 184 | 0 |
| TRICIDA INC | COM | 89610F101 | 2,204 | 475,000 | SH | | DFND | 1 | 0 | 475,000 | 0 |
| TRICIDA INC | COM | 89610F901 | 68 | 146 | SH | Call | DFND | 1 | 0 | 146 | 0 |
| TRILLIUM THERAPEUTICS INC | COM | 89620X506 | 1,229 | 70,000 | SH | | DFND | 1 | 0 | 70,000 | 0 |
| TRILLIUM THERAPEUTICS INC | COM | 89620X906 | 211 | 120 | SH | Call | DFND | 1 | 0 | 120 | 0 |
| TRILLIUM THERAPEUTICS INC | COM | 89620X956 | 1,947 | 1,109 | SH | Put | DFND | 1 | 0 | 1,109 | 0 |
| TWIN VEE POWERCATS CO | COM | 90177C101 | 319 | 88,777 | SH | | DFND | 1 | 0 | 88,777 | 0 |
| UCOMMUNE INTL LTD | COM | G9449A100 | 260 | 298,798 | SH | | DFND | 1 | 0 | 298,798 | 0 |
| VASCULAR BIOGENICS LTD | COM | M96883909 | 41 | 198 | SH | Call | DFND | 1 | 0 | 198 | 0 |
| VAXCYTE INC | COM | 92243G108 | 1,687 | 66,483 | SH | | DFND | 1 | 0 | 66,483 | 0 |
| VINCERX PHARMA INC | COM | 92731L106 | 3,234 | 200,000 | SH | | DFND | 1 | 0 | 200,000 | 0 |
| VIRPAX PHARMACEUTICALS INC | COM | 928251107 | 4,766 | 993,000 | SH | | DFND | 1 | 0 | 993,000 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H952 | 67 | 244 | SH | Put | DFND | 1 | 0 | 244 | 0 |
| WIMI HOLOGRAM CLOUD INC | ADS | 97264L100 | 1,581 | 383,791 | SH | | DFND | 1 | 0 | 383,791 | 0 |
| WIMI HOLOGRAM CLOUD INC | ADS | 97264L950 | 1,403 | 3,405 | SH | Put | DFND | 1 | 0 | 3,405 | 0 |
| XPRESSPA GROUP INC | COM | 98420U953 | 1,756 | 11,948 | SH | Put | DFND | 1 | 0 | 11,948 | 0 |
