| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 | 14,702 | 355,626 | SH | | DFND | 1 | 0 | 355,626 | 0 |
| ABBVIE INC | COM | 00287Y909 | 12,096 | 2,926 | SH | Call | DFND | 1 | 0 | 2,926 | 0 |
| ABBVIE INC | COM | 00287Y959 | 38,252 | 9,253 | SH | Put | DFND | 1 | 0 | 9,253 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 14,597 | 804,255 | SH | | DFND | 1 | 0 | 804,255 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 45,705 | 25,182 | SH | Call | DFND | 1 | 0 | 25,182 | 0 |
| ACCURAY INC | COM | 004397105 | 244 | 42,491 | SH | | DFND | 1 | 0 | 42,491 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 6,119 | 7,480 | SH | Call | DFND | 1 | 0 | 7,480 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 1,773 | 2,167 | SH | Put | DFND | 1 | 0 | 2,167 | 0 |
| ACORDA THERAPEUTICS INC | COM | 00484M906 | 10,748 | 3,258 | SH | Call | DFND | 1 | 0 | 3,258 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 37,615 | 593,862 | SH | | DFND | 1 | 0 | 593,862 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E902 | 7,189 | 1,135 | SH | Call | DFND | 1 | 0 | 1,135 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E952 | 15,012 | 2,370 | SH | Put | DFND | 1 | 0 | 2,370 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351909 | 3,588 | 389 | SH | Call | DFND | 1 | 0 | 389 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384909 | 890 | 2,050 | SH | Call | DFND | 1 | 0 | 2,050 | 0 |
| ALIGN TECHNOLOGY INC | COM | 016255901 | 3,293 | 889 | SH | Call | DFND | 1 | 0 | 889 | 0 |
| ALLERGAN INC | COM | 018490902 | 30,318 | 3,599 | SH | Call | DFND | 1 | 0 | 3,599 | 0 |
| ALLERGAN INC | COM | 018490952 | 4,254 | 505 | SH | Put | DFND | 1 | 0 | 505 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 1,451 | 468 | SH | Call | DFND | 1 | 0 | 468 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111206 | 1,457 | 251,271 | SH | | DFND | 1 | 0 | 251,271 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111906 | 4,938 | 8,513 | SH | Call | DFND | 1 | 0 | 8,513 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111956 | 3,921 | 6,761 | SH | Put | DFND | 1 | 0 | 6,761 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U102 | 7,066 | 15,259,074 | SH | | DFND | 1 | 0 | 15,259,074 | 0 |
| ARCA BIOPHARMA INC | COM | 00211Y209 | 1,276 | 988,934 | SH | | DFND | 1 | 0 | 988,934 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 7,865 | 10,214 | SH | Call | DFND | 1 | 0 | 10,214 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 7,236 | 9,398 | SH | Put | DFND | 1 | 0 | 9,398 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 514 | 294 | SH | Call | DFND | 1 | 0 | 294 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 836 | 478 | SH | Put | DFND | 1 | 0 | 478 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797209 | 4,554 | 2,276,980 | SH | | DFND | 1 | 0 | 2,276,980 | 0 |
| ASTEX PHARMACEUTICALS INC | COM | 04624B903 | 948 | 2,307 | SH | Call | DFND | 1 | 0 | 2,307 | 0 |
| ASTEX PHARMACEUTICALS INC | COM | 04624B953 | 429 | 1,043 | SH | Put | DFND | 1 | 0 | 1,043 | 0 |
| ASTRAZENECA PLC - ADR | ADR | 046353908 | 22,841 | 4,829 | SH | Call | DFND | 1 | 0 | 4,829 | 0 |
| ATHERSYS INC | COM | 04744L106 | 499 | 300,745 | SH | | DFND | 1 | 0 | 300,745 | 0 |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D107 | 6,205 | 3,731 | SH | Call | DFND | 1 | 0 | 3,731 | 0 |
| AVANIR PHARMACEUTICALS INC | COM | 05348P401 | 1,150 | 250,000 | SH | | DFND | 1 | 0 | 250,000 | 0 |
| BAXTER INTERNATIONAL INC | COM | 071813109 | 800 | 11,553 | SH | | DFND | 1 | 0 | 11,553 | 0 |
| BAXTER INTERNATIONAL INC | COM | 071813909 | 16,909 | 2,441 | SH | Call | DFND | 1 | 0 | 2,441 | 0 |
| BIODEL INC | COM | 09064M904 | 1,271 | 3,041 | SH | Call | DFND | 1 | 0 | 3,041 | 0 |
| BIODEL INC | COM | 09064M954 | 322 | 771 | SH | Put | DFND | 1 | 0 | 771 | 0 |
| BRIDGEPOINT EDUCATION INC | COM | 10807M905 | 3,812 | 3,130 | SH | Call | DFND | 1 | 0 | 3,130 | 0 |
| BRIDGEPOINT EDUCATION INC | COM | 10807M955 | 5,335 | 4,380 | SH | Put | DFND | 1 | 0 | 4,380 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 7,575 | 1,695 | SH | Call | DFND | 1 | 0 | 1,695 | 0 |
| CARDICA INC | COM | 14141R101 | 354 | 318,984 | SH | | DFND | 1 | 0 | 318,984 | 0 |
| CELGENE CORP | COM | 151020904 | 55,789 | 4,772 | SH | Call | DFND | 1 | 0 | 4,772 | 0 |
| CELGENE CORP | COM | 151020954 | 6,711 | 574 | SH | Put | DFND | 1 | 0 | 574 | 0 |
| CELSION CORPORATION | COM | 15117N905 | 659 | 6,462 | SH | Call | DFND | 1 | 0 | 6,462 | 0 |
| CELSION CORPORATION | COM | 15117N955 | 235 | 2,302 | SH | Put | DFND | 1 | 0 | 2,302 | 0 |
| CEMPRA INC | COM | 15130J109 | 1,175 | 150,000 | SH | | DFND | 1 | 0 | 150,000 | 0 |
| CERUS CORP | COM | 157085901 | 211 | 477 | SH | Call | DFND | 1 | 0 | 477 | 0 |
| COPART INC | COM | 217204906 | 5,541 | 1,799 | SH | Call | DFND | 1 | 0 | 1,799 | 0 |
| CORONADO BIOSCIENCES INC | COM | 21976U909 | 420 | 488 | SH | Call | DFND | 1 | 0 | 488 | 0 |
| CORONADO BIOSCIENCES INC | COM | 21976U959 | 283 | 329 | SH | Put | DFND | 1 | 0 | 329 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678907 | 6,168 | 1,277 | SH | Call | DFND | 1 | 0 | 1,277 | 0 |
| CYBERONICS INC | COM | 23251P102 | 8,450 | 162,625 | SH | | DFND | 1 | 0 | 162,625 | 0 |
| CYBERONICS INC | COM | 23251P952 | 30,911 | 5,949 | SH | Put | DFND | 1 | 0 | 5,949 | 0 |
| DENDREON CORP | COM | 24823Q907 | 2,809 | 6,819 | SH | Call | DFND | 1 | 0 | 6,819 | 0 |
| DENDREON CORP | COM | 24823Q957 | 700 | 1,700 | SH | Put | DFND | 1 | 0 | 1,700 | 0 |
| EDAP TMS SA -ADR | ADR | 268311107 | 3,268 | 1,197,086 | SH | | DFND | 1 | 0 | 1,197,086 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E908 | 11,411 | 1,698 | SH | Call | DFND | 1 | 0 | 1,698 | 0 |
| ELAN CORPORATION PLC - ADR | ADR | 284131908 | 11,777 | 8,329 | SH | Call | DFND | 1 | 0 | 8,329 | 0 |
| ELI LILLY & CO | COM | 532457108 | 895 | 18,222 | SH | | DFND | 1 | 0 | 18,222 | 0 |
| ELI LILLY & CO | COM | 532457908 | 50,289 | 10,238 | SH | Call | DFND | 1 | 0 | 10,238 | 0 |
| ELI LILLY & CO | COM | 532457958 | 1,999 | 407 | SH | Put | DFND | 1 | 0 | 407 | 0 |
| ENDO HEALTH SOLUTIONS INC | COM | 29264F955 | 5,129 | 1,394 | SH | Put | DFND | 1 | 0 | 1,394 | 0 |
| ENTREMED INC | COM | 29382F202 | 2,369 | 1,172,590 | SH | | DFND | 1 | 0 | 1,172,590 | 0 |
| EXELIXIS INC | COM | 30161Q104 | 217 | 478 | SH | Call | DFND | 1 | 0 | 478 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 287 | 1,291 | SH | Put | DFND | 1 | 0 | 1,291 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 8,916 | 174,108 | SH | | DFND | 1 | 0 | 174,108 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 13,857 | 2,706 | SH | Call | DFND | 1 | 0 | 2,706 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 38,561 | 7,530 | SH | Put | DFND | 1 | 0 | 7,530 | 0 |
| GTX INC | COM | 40052B908 | 578 | 876 | SH | Call | DFND | 1 | 0 | 876 | 0 |
| INCYTE CORP | COM | 45337C902 | 948 | 431 | SH | Call | DFND | 1 | 0 | 431 | 0 |
| INFINITY PHARMACEUTICALS | COM | 45665G303 | 474 | 29,188 | SH | | DFND | 1 | 0 | 29,188 | 0 |
| INFINITY PHARMACEUTICALS | COM | 45665G903 | 1,082 | 666 | SH | Call | DFND | 1 | 0 | 666 | 0 |
| INSMED INC | COM | 457669907 | 2,243 | 1,875 | SH | Call | DFND | 1 | 0 | 1,875 | 0 |
| INSPIREMD INC | COM | 45779A309 | 235 | 106,800 | SH | | DFND | 1 | 0 | 106,800 | 0 |
| INTERMUNE INC | COM | 45884X903 | 3,121 | 3,244 | SH | Call | DFND | 1 | 0 | 3,244 | 0 |
| INTERMUNE INC | COM | 45884X953 | 1,625 | 1,689 | SH | Put | DFND | 1 | 0 | 1,689 | 0 |
| ISHARES 20+ YEAR TREASURY | COM | 464287432 | 11,491 | 104,050 | SH | | DFND | 1 | 0 | 104,050 | 0 |
| ISHARES 20+ YEAR TREASURY | COM | 464287952 | 22,088 | 2,000 | SH | Put | DFND | 1 | 0 | 2,000 | 0 |
| ISHARES RUSSELL 2000 INDEX FUND | COM | 464287655 | 48,580 | 5,000 | SH | Put | DFND | 1 | 0 | 5,000 | 0 |
| ISIS PHARMACEUTICALS INC SHS | COM | 464330909 | 2,714 | 1,010 | SH | Call | DFND | 1 | 0 | 1,010 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515101 | 5,568 | 745,435 | SH | | DFND | 1 | 0 | 745,435 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515901 | 683 | 914 | SH | Call | DFND | 1 | 0 | 914 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 6,880 | 9,210 | SH | Put | DFND | 1 | 0 | 9,210 | 0 |
| LINN ENERGY LLC PARTNERSHIP UNIT | UNIT | 536020900 | 4,370 | 1,317 | SH | Call | DFND | 1 | 0 | 1,317 | 0 |
| LINN ENERGY LLC PARTNERSHIP UNIT | UNIT | 536020950 | 332 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| LPATH INC | COM | 548910306 | 312 | 70,907 | SH | | DFND | 1 | 0 | 70,907 | 0 |
| MAKO SURGICAL CORP | COM | 560879908 | 2,645 | 2,195 | SH | Call | DFND | 1 | 0 | 2,195 | 0 |
| MANNKIND CORP | COM | 56400P201 | 832 | 128,007 | SH | | DFND | 1 | 0 | 128,007 | 0 |
| MANNKIND CORP | COM | 56400P901 | 25,221 | 38,801 | SH | Call | DFND | 1 | 0 | 38,801 | 0 |
| MANNKIND CORP | COM | 56400P951 | 5,824 | 8,960 | SH | Put | DFND | 1 | 0 | 8,960 | 0 |
| MAST THERAPEUTICS INC | COM | 576314108 | 3,310 | 7,711,867 | SH | | DFND | 1 | 0 | 7,711,867 | 0 |
| MEDGENICS INC | COM | 58436Q203 | 1,625 | 427,684 | SH | | DFND | 1 | 0 | 427,684 | 0 |
| MEDIVATION INC | COM | 58501N101 | 2,357 | 47,900 | SH | | DFND | 1 | 0 | 47,900 | 0 |
| MEDIVATION INC | COM | 58501N901 | 3,715 | 755 | SH | Call | DFND | 1 | 0 | 755 | 0 |
| MEDIVATION INC | COM | 58501N951 | 6,219 | 1,264 | SH | Put | DFND | 1 | 0 | 1,264 | 0 |
| MEI PHARMA INC | COM | 55279B202 | 760 | 106,600 | SH | | DFND | 1 | 0 | 106,600 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 61,523 | 13,245 | SH | Call | DFND | 1 | 0 | 13,245 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 1,361 | 293 | SH | Put | DFND | 1 | 0 | 293 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T900 | 786 | 522 | SH | Call | DFND | 1 | 0 | 522 | 0 |
| MYRIAD GENETICS INC | COM | 62855J904 | 11,087 | 4,126 | SH | Call | DFND | 1 | 0 | 4,126 | 0 |
| MYRIAD GENETICS INC | COM | 62855J954 | 4,122 | 1,534 | SH | Put | DFND | 1 | 0 | 1,534 | 0 |
| NAVIDEA BIOPHARMACEUTICALS INC | COM | 63937X103 | 603 | 2,260 | SH | Call | DFND | 1 | 0 | 2,260 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 5,166 | 3,861 | SH | Call | DFND | 1 | 0 | 3,861 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C959 | 1,412 | 1,055 | SH | Put | DFND | 1 | 0 | 1,055 | 0 |
| NEUROMETRIX INC | COM | 641255302 | 357 | 178,387 | SH | | DFND | 1 | 0 | 178,387 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 7,825 | 3,968 | SH | Call | DFND | 1 | 0 | 3,968 | 0 |
| NORTHWEST BIOTHERAPEUTICS | COM | 66737P600 | 2,908 | 870,543 | SH | | DFND | 1 | 0 | 870,543 | 0 |
| NUSTAR ENERGY LP | UNIT | 67058H102 | 1,077 | 23,584 | SH | | DFND | 1 | 0 | 23,584 | 0 |
| NUSTAR ENERGY LP | UNIT | 67058H102 | 6,163 | 1,350 | SH | Call | DFND | 1 | 0 | 1,350 | 0 |
| NUSTAR ENERGY LP | UNIT | 67058H102 | 1,379 | 302 | SH | Put | DFND | 1 | 0 | 302 | 0 |
| ONCOGENEX PHARMACEUTICAL | COM | 68230A106 | 3,888 | 396,730 | SH | | DFND | 1 | 0 | 396,730 | 0 |
| ONCOGENEX PHARMACEUTICAL | COM | 68230A956 | 1,735 | 1,770 | SH | Put | DFND | 1 | 0 | 1,770 | 0 |
| ONYX PHARMACEUTICALS INC | COM | 683399909 | 21,454 | 2,470 | SH | Call | DFND | 1 | 0 | 2,470 | 0 |
| ONYX PHARMACEUTICALS INC | COM | 683399959 | 2,354 | 271 | SH | Put | DFND | 1 | 0 | 271 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 3,011 | 4,241 | SH | Put | DFND | 1 | 0 | 4,241 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164904 | 4,447 | 7,602 | SH | Call | DFND | 1 | 0 | 7,602 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164954 | 255 | 436 | SH | Put | DFND | 1 | 0 | 436 | 0 |
| PALATIN TECHNOLOGIES INC | COM | 696077403 | 257 | 427,609 | SH | | DFND | 1 | 0 | 427,609 | 0 |
| PBF ENERGY INC | COM | 69318G906 | 805 | 311 | SH | Call | DFND | 1 | 0 | 311 | 0 |
| PEREGRINE PHARMACEUTICALS | COM | 713661304 | 385 | 298,200 | SH | | DFND | 1 | 0 | 298,200 | 0 |
| PEREGRINE PHARMACEUTICALS | COM | 713661904 | 320 | 2,478 | SH | Call | DFND | 1 | 0 | 2,478 | 0 |
| PEREGRINE PHARMACEUTICALS | COM | 713661954 | 486 | 3,770 | SH | Put | DFND | 1 | 0 | 3,770 | 0 |
| PERRIGO CO | COM | 714290903 | 27,104 | 2,240 | SH | Call | DFND | 1 | 0 | 2,240 | 0 |
| QLT INC | COM | 746927102 | 295 | 67,300 | SH | | DFND | 1 | 0 | 67,300 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 48,057 | 2,137 | SH | Call | DFND | 1 | 0 | 2,137 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F957 | 12,751 | 567 | SH | Put | DFND | 1 | 0 | 567 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H209 | 1,146 | 62,090 | SH | | DFND | 1 | 0 | 62,090 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H909 | 369 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 4,325 | 2,344 | SH | Put | DFND | 1 | 0 | 2,344 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374902 | 1,747 | 4,839 | SH | Call | DFND | 1 | 0 | 4,839 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 304 | 842 | SH | Put | DFND | 1 | 0 | 842 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 17,309 | 454,899 | SH | | DFND | 1 | 0 | 454,899 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 8,595 | 2,259 | SH | Call | DFND | 1 | 0 | 2,259 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 20,817 | 5,471 | SH | Put | DFND | 1 | 0 | 5,471 | 0 |
| SOLAZYME INC | COM | 83415T901 | 3,004 | 2,563 | SH | Call | DFND | 1 | 0 | 2,563 | 0 |
| SOLAZYME INC | COM | 83415T951 | 1,808 | 1,543 | SH | Put | DFND | 1 | 0 | 1,543 | 0 |
| SPDR S&P 500 ETF TRUST | UNIT | 78462F953 | 72,005 | 4,500 | SH | Put | DFND | 1 | 0 | 4,500 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328601 | 939 | 180,300 | SH | | DFND | 1 | 0 | 180,300 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328951 | 1,042 | 2,000 | SH | Put | DFND | 1 | 0 | 2,000 | 0 |
| SYNERGY PHARMACEUTICALS WTS | COM | 871639118 | 610 | 331,486 | SH | Call | DFND | 1 | 0 | 331,486 | 0 |
| SYNTA PHARMACEUTICALS CORP | COM | 87162T206 | 1,079 | 216,268 | SH | | DFND | 1 | 0 | 216,268 | 0 |
| SYNTA PHARMACEUTICALS CORP | COM | 87162T956 | 1,087 | 2,179 | SH | Put | DFND | 1 | 0 | 2,179 | 0 |
| TARGACEPT INC | COM | 87611R906 | 352 | 824 | SH | Call | DFND | 1 | 0 | 824 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES | ADR | 881624909 | 4,363 | 1,113 | SH | Call | DFND | 1 | 0 | 1,113 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES | ADR | 881624959 | 7,428 | 1,895 | SH | Put | DFND | 1 | 0 | 1,895 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES | ADR | 881624209 | 813 | 20,736 | SH | | DFND | 1 | 0 | 20,736 | 0 |
| THERAPEUTICSMD INC | COM | 88338N107 | 944 | 311,584 | SH | | DFND | 1 | 0 | 311,584 | 0 |
| THERAVANCE INC | COM | 88338T904 | 3,660 | 950 | SH | Call | DFND | 1 | 0 | 950 | 0 |
| TRANSCEPT PHARMACEUTICALS | COM | 89354M106 | 610 | 202,036 | SH | | DFND | 1 | 0 | 202,036 | 0 |
| TRANSCEPT PHARMACEUTICALS | COM | 89354M956 | 523 | 1,732 | SH | Put | DFND | 1 | 0 | 1,732 | 0 |
| UNI-PIXEL INC | COM | 904572953 | 871 | 592 | SH | Put | DFND | 1 | 0 | 592 | 0 |
| VALEANT PHARMACEUTICALS INTERNATIONAL | COM | 91911K902 | 12,266 | 1,425 | SH | Call | DFND | 1 | 0 | 1,425 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 459 | 56,843 | SH | | DFND | 1 | 0 | 56,843 | 0 |
| VENTRUS BIOSCIENCES INC | COM | 922822101 | 1,669 | 695,400 | SH | | DFND | 1 | 0 | 695,400 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 1,207 | 15,108 | SH | | DFND | 1 | 0 | 15,108 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 184,220 | 23,065 | SH | Call | DFND | 1 | 0 | 23,065 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 41,988 | 5,257 | SH | Put | DFND | 1 | 0 | 5,257 | 0 |
| VICAL INC | COM | 925602904 | 1,030 | 3,291 | SH | Call | DFND | 1 | 0 | 3,291 | 0 |
| VICAL INC | COM | 925602954 | 325 | 1,038 | SH | Put | DFND | 1 | 0 | 1,038 | 0 |
| VIVUS INC | COM | 928551900 | 2,568 | 2,041 | SH | Call | DFND | 1 | 0 | 2,041 | 0 |
| VIVUS INC | COM | 928551950 | 1,510 | 1,200 | SH | Put | DFND | 1 | 0 | 1,200 | 0 |
| WELLCARE HEALTH PLANS INC | COM | 94946T906 | 10,027 | 1,805 | SH | Call | DFND | 1 | 0 | 1,805 | 0 |
| WELLPOINT INC | COM | 94973V907 | 12,693 | 1,551 | SH | Call | DFND | 1 | 0 | 1,551 | 0 |
| WELLPOINT INC | COM | 94973V957 | 12,693 | 1,551 | SH | Put | DFND | 1 | 0 | 1,551 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P901 | 688 | 3,276 | SH | Call | DFND | 1 | 0 | 3,276 | 0 |
| ZOETIS INC | CL A | 98978V103 | 14,210 | 460,030 | SH | | DFND | 1 | 0 | 460,030 | 0 |
| ZOETIS INC | CL A | 98978V903 | 3,784 | 1,225 | SH | Call | DFND | 1 | 0 | 1,225 | 0 |
| ZOETIS INC | CL A | 98978V953 | 16,962 | 5,491 | SH | Put | DFND | 1 | 0 | 5,491 | 0 |
