| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AASTROM BIOSCIENCES INC | COM | 00253U305 | 1,437 | 5,189,214 | SH | | DFND | 1 | 0 | 5,189,214 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 11,719 | 426,600 | SH | | DFND | 1 | 0 | 426,600 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 81,976 | 29,842 | SH | Call | DFND | 1 | 0 | 29,842 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225958 | 2,288 | 833 | SH | Put | DFND | 1 | 0 | 833 | 0 |
| ACCURAY INC | COM | 004397105 | 739 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| ACCURAY INC | COM | 004397905 | 188 | 254 | SH | Call | DFND | 1 | 0 | 254 | 0 |
| ACCURAY INC | COM | 004397955 | 1,035 | 1,400 | SH | Put | DFND | 1 | 0 | 1,400 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 1,595 | 148,070 | SH | | DFND | 1 | 0 | 148,070 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T900 | 215 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 1,464 | 484,879 | SH | | DFND | 1 | 0 | 484,879 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 7,290 | 24,139 | SH | Call | DFND | 1 | 0 | 24,139 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 802 | 2,654 | SH | Put | DFND | 1 | 0 | 2,654 | 0 |
| ACORDA THERAPEUTICS INC | COM | 00484M106 | 369 | 108 | SH | Call | DFND | 1 | 0 | 108 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 22,209 | 259,119 | SH | | DFND | 1 | 0 | 259,119 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E902 | 18,856 | 2,200 | SH | Call | DFND | 1 | 0 | 2,200 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E952 | 26,390 | 3,079 | SH | Put | DFND | 1 | 0 | 3,079 | 0 |
| AGENUS INC | COM | 00847G705 | 4,885 | 1,763,663 | SH | | DFND | 1 | 0 | 1,763,663 | 0 |
| AGENUS INC | COM | 00847G905 | 96 | 347 | SH | Call | DFND | 1 | 0 | 347 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 12,963 | 1,116 | SH | Call | DFND | 1 | 0 | 1,116 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384909 | 1,044 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALLERGAN INC | COM | 018490902 | 22,974 | 2,540 | SH | Call | DFND | 1 | 0 | 2,540 | 0 |
| ALLERGAN INC | COM | 018490952 | 18,388 | 2,033 | SH | Put | DFND | 1 | 0 | 2,033 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111206 | 1,162 | 183,845 | SH | | DFND | 1 | 0 | 183,845 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111906 | 7,302 | 11,554 | SH | Call | DFND | 1 | 0 | 11,554 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111956 | 1,951 | 3,087 | SH | Put | DFND | 1 | 0 | 3,087 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U201 | 7,053 | 1,754,600 | SH | | DFND | 1 | 0 | 1,754,600 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V959 | 109 | 264 | SH | Put | DFND | 1 | 0 | 264 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 10,835 | 20,560 | SH | Call | DFND | 1 | 0 | 20,560 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 1,459 | 2,769 | SH | Put | DFND | 1 | 0 | 2,769 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A100 | 581 | 31,553 | SH | | DFND | 1 | 0 | 31,553 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 1,601 | 870 | SH | Call | DFND | 1 | 0 | 870 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 2,997 | 1,629 | SH | Put | DFND | 1 | 0 | 1,629 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797909 | 250 | 439 | SH | Call | DFND | 1 | 0 | 439 | 0 |
| ASTEX PHARMACEUTICALS INC | COM | 04624B103 | 845 | 99,703 | SH | | DFND | 1 | 0 | 99,703 | 0 |
| ASTEX PHARMACEUTICALS INC | COM | 04624B903 | 740 | 873 | SH | Call | DFND | 1 | 0 | 873 | 0 |
| ASTEX PHARMACEUTICALS INC | COM | 04624B953 | 861 | 1,015 | SH | Put | DFND | 1 | 0 | 1,015 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353108 | 1,381 | 26,585 | SH | | DFND | 1 | 0 | 26,585 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353908 | 1,252 | 241 | SH | Call | DFND | 1 | 0 | 241 | 0 |
| ASTRAZENECA PLC-SPONS ADR | ADR | 046353958 | 10,698 | 2,060 | SH | Put | DFND | 1 | 0 | 2,060 | 0 |
| ATHERSYS INC | COM | 04744L906 | 22 | 133 | SH | Call | DFND | 1 | 0 | 133 | 0 |
| ATHERSYS INC | COM | 04744L956 | 40 | 245 | SH | Put | DFND | 1 | 0 | 245 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P401 | 282 | 66,518 | SH | | DFND | 1 | 0 | 66,518 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P951 | 1,074 | 2,534 | SH | Put | DFND | 1 | 0 | 2,534 | 0 |
| BAXTER INTERNATIONAL INC | COM | 071813909 | 10,944 | 1,666 | SH | Call | DFND | 1 | 0 | 1,666 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V903 | 446 | 613 | SH | Call | DFND | 1 | 0 | 613 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 21,042 | 874 | SH | Call | DFND | 1 | 0 | 874 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G901 | 3,012 | 417 | SH | Call | DFND | 1 | 0 | 417 | 0 |
| BLACKBERRY LTD | COM | 09228F953 | 5,005 | 6,296 | SH | Put | DFND | 1 | 0 | 6,296 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 28,411 | 6,139 | SH | Call | DFND | 1 | 0 | 6,139 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122958 | 278 | 60 | SH | Put | DFND | 1 | 0 | 60 | 0 |
| CELGENE CORP | COM | 151020904 | 12,422 | 807 | SH | Call | DFND | 1 | 0 | 807 | 0 |
| CELGENE CORP | COM | 151020954 | 18,133 | 1,178 | SH | Put | DFND | 1 | 0 | 1,178 | 0 |
| CELLDEX THERAPEUTICS INC | COM | 15117B103 | 1,133 | 31,979 | SH | | DFND | 1 | 0 | 31,979 | 0 |
| CELLDEX THERAPEUTICS INC | COM | 15117B903 | 16,234 | 4,582 | SH | Call | DFND | 1 | 0 | 4,582 | 0 |
| CELLDEX THERAPEUTICS INC | COM | 15117B953 | 4,032 | 1,138 | SH | Put | DFND | 1 | 0 | 1,138 | 0 |
| CELSION CORPORATION | COM | 15117N905 | 689 | 5,990 | SH | Call | DFND | 1 | 0 | 5,990 | 0 |
| CELSION CORPORATION | COM | 15117N955 | 710 | 6,174 | SH | Put | DFND | 1 | 0 | 6,174 | 0 |
| CEMPRA INC | COM | 15130J109 | 1,709 | 148,572 | SH | | DFND | 1 | 0 | 148,572 | 0 |
| CHEMOCENTRYX INC | COM | 16383L956 | 86 | 155 | SH | Put | DFND | 1 | 0 | 155 | 0 |
| CONATUS PHARMACEUTICALS INC | COM | 20600T108 | 921 | 91,600 | SH | | DFND | 1 | 0 | 91,600 | 0 |
| CORONADO BIOSCIENCES INC | COM | 21976U909 | 748 | 1,066 | SH | Call | DFND | 1 | 0 | 1,066 | 0 |
| CORONADO BIOSCIENCES INC | COM | 21976U959 | 304 | 433 | SH | Put | DFND | 1 | 0 | 433 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678907 | 13,968 | 2,198 | SH | Call | DFND | 1 | 0 | 2,198 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678957 | 394 | 62 | SH | Put | DFND | 1 | 0 | 62 | 0 |
| CYBERONICS INC | COM | 23251P102 | 303 | 5,977 | SH | | DFND | 1 | 0 | 5,977 | 0 |
| CYBERONICS INC | COM | 23251P952 | 8,590 | 1,693 | SH | Put | DFND | 1 | 0 | 1,693 | 0 |
| CYTRX CORP | COM | 232828909 | 40 | 125 | SH | Call | DFND | 1 | 0 | 125 | 0 |
| DENDREON CORP | COM | 24823Q107 | 263 | 89,800 | SH | | DFND | 1 | 0 | 89,800 | 0 |
| DENDREON CORP | COM | 24823Q957 | 421 | 1,436 | SH | Put | DFND | 1 | 0 | 1,436 | 0 |
| DYAX CORP | COM | 26746E103 | 682 | 99,458 | SH | | DFND | 1 | 0 | 99,458 | 0 |
| EDAP TMS SA -ADR | ADR | 268311107 | 3,187 | 1,259,500 | SH | | DFND | 1 | 0 | 1,259,500 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E908 | 11,823 | 1,698 | SH | Call | DFND | 1 | 0 | 1,698 | 0 |
| ELAN CORPORATION PLC | ADR | 284131908 | 1,714 | 1,100 | SH | Call | DFND | 1 | 0 | 1,100 | 0 |
| ELI LILLY & CO | COM | 532457108 | 1,669 | 33,156 | SH | | DFND | 1 | 0 | 33,156 | 0 |
| ELI LILLY & CO | COM | 532457958 | 2,048 | 407 | SH | Put | DFND | 1 | 0 | 407 | 0 |
| ENDOCYTE INC | COM | 29269A902 | 143 | 107 | SH | Call | DFND | 1 | 0 | 107 | 0 |
| ENDOCYTE INC | COM | 29269A952 | 547 | 410 | SH | Put | DFND | 1 | 0 | 410 | 0 |
| ENTREMED INC | COM | 29382F202 | 2,063 | 1,178,956 | SH | | DFND | 1 | 0 | 1,178,956 | 0 |
| EXACT SCIENCES CORP | COM | 30063P905 | 1,211 | 1,025 | SH | Call | DFND | 1 | 0 | 1,025 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 2,425 | 4,167 | SH | Call | DFND | 1 | 0 | 4,167 | 0 |
| FIBROCELL SCIENCE INC | COM | 315721209 | 1,099 | 251,000 | SH | | DFND | 1 | 0 | 251,000 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 1,814 | 7,990 | SH | Put | DFND | 1 | 0 | 7,990 | 0 |
| GERON CORP | COM | 374163103 | 366 | 109,375 | SH | | DFND | 1 | 0 | 109,375 | 0 |
| GERON CORP | COM | 374163903 | 376 | 1,122 | SH | Call | DFND | 1 | 0 | 1,122 | 0 |
| GERON CORP | COM | 374163953 | 697 | 2,080 | SH | Put | DFND | 1 | 0 | 2,080 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 9,732 | 154,871 | SH | | DFND | 1 | 0 | 154,871 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 15,710 | 2,500 | SH | Call | DFND | 1 | 0 | 2,500 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 53,452 | 8,506 | SH | Put | DFND | 1 | 0 | 8,506 | 0 |
| GLAXOSMITHKLINE PLC | ADR | 37733W905 | 32,766 | 6,531 | SH | Call | DFND | 1 | 0 | 6,531 | 0 |
| GLAXOSMITHKLINE PLC | ADR | 37733W955 | 5,920 | 1,180 | SH | Put | DFND | 1 | 0 | 1,180 | 0 |
| HOLOGIC INC | COM | 436440901 | 2,292 | 1,110 | SH | Call | DFND | 1 | 0 | 1,110 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536955 | 914 | 3,557 | SH | Put | DFND | 1 | 0 | 3,557 | 0 |
| INCYTE CORP | COM | 45337C902 | 1,644 | 431 | SH | Call | DFND | 1 | 0 | 431 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G903 | 886 | 508 | SH | Call | DFND | 1 | 0 | 508 | 0 |
| INSMED INC | COM | 457669957 | 2,248 | 1,440 | SH | Put | DFND | 1 | 0 | 1,440 | 0 |
| INTERMUNE INC | COM | 45884X903 | 6,400 | 4,164 | SH | Call | DFND | 1 | 0 | 4,164 | 0 |
| INTERMUNE INC | COM | 45884X953 | 2,596 | 1,689 | SH | Put | DFND | 1 | 0 | 1,689 | 0 |
| ISHARES 20+ YEAR TREASURY BOND ETF | ETF | 464287902 | 45,220 | 4,250 | SH | Call | DFND | 1 | 0 | 4,250 | 0 |
| ISHARES 20+ YEAR TREASURY BOND ETF | ETF | 464287952 | 23,940 | 2,250 | SH | Put | DFND | 1 | 0 | 2,250 | 0 |
| ISHARES MSCI JAPAN ETF | ETF | 464286848 | 298 | 25,000 | SH | | DFND | 1 | 0 | 25,000 | 0 |
| ISHARES MSCI JAPAN ETF | ETF | 464286958 | 59,550 | 50,000 | SH | Put | DFND | 1 | 0 | 50,000 | 0 |
| ISHARES RUSSELL 2000 ETF | ETF | 464287955 | 37,082 | 3,478 | SH | Put | DFND | 1 | 0 | 3,478 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330109 | 438 | 11,663 | SH | | DFND | 1 | 0 | 11,663 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330909 | 488 | 130 | SH | Call | DFND | 1 | 0 | 130 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330959 | 3,762 | 1,002 | SH | Put | DFND | 1 | 0 | 1,002 | 0 |
| ISORAY INC | COM | 46489V104 | 1,079 | 1,663,098 | SH | | DFND | 1 | 0 | 1,663,098 | 0 |
| KALOBIOS PHARMACEUTICALS INC | COM | 48344T100 | 476 | 105,408 | SH | | DFND | 1 | 0 | 105,408 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515101 | 383 | 37,890 | SH | | DFND | 1 | 0 | 37,890 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515901 | 554 | 549 | SH | Call | DFND | 1 | 0 | 333 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 2,304 | 2,281 | SH | Put | DFND | 1 | 0 | 2,281 | 0 |
| MANNKIND CORP | COM | 56400P201 | 5,324 | 934,021 | SH | | DFND | 1 | 0 | 934,021 | 0 |
| MANNKIND CORP | COM | 56400P901 | 20,024 | 35,130 | SH | Call | DFND | 1 | 0 | 35,130 | 0 |
| MANNKIND CORP | COM | 56400P951 | 9,043 | 15,865 | SH | Put | DFND | 1 | 0 | 15,865 | 0 |
| MAST THERAPEUTICS INC | COM | 576314108 | 1,598 | 3,639,571 | SH | | DFND | 1 | 0 | 3,639,571 | 0 |
| MEDICINES CO | COM | 584688905 | 2,028 | 605 | SH | Call | DFND | 1 | 0 | 605 | 0 |
| MEDIVATION INC | COM | 58501N101 | 6,764 | 112,849 | SH | | DFND | 1 | 0 | 112,849 | 0 |
| MEDIVATION INC | COM | 58501N901 | 6,863 | 1,145 | SH | Call | DFND | 1 | 0 | 1,145 | 0 |
| MEDIVATION INC | COM | 58501N951 | 29,478 | 4,918 | SH | Put | DFND | 1 | 0 | 4,918 | 0 |
| MEI PHARMA | COM | 55279B902 | 454 | 400 | SH | Call | DFND | 1 | 0 | 400 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 82,165 | 17,258 | SH | Call | DFND | 1 | 0 | 17,258 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 1,395 | 293 | SH | Put | DFND | 1 | 0 | 293 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T900 | 751 | 522 | SH | Call | DFND | 1 | 0 | 522 | 0 |
| NANOSPHERE INC | COM | 63009F105 | 690 | 345,121 | SH | | DFND | 1 | 0 | 345,121 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268908 | 686 | 656 | SH | Call | DFND | 1 | 0 | 656 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268958 | 941 | 900 | SH | Put | DFND | 1 | 0 | 900 | 0 |
| NEUROMETRIX INC | COM | 64125C109 | 361 | 218,849 | SH | | DFND | 1 | 0 | 218,849 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 9,033 | 4,810 | SH | Call | DFND | 1 | 0 | 4,810 | 0 |
| NORTHWEST BIOTHERAPEUTICS | COM | 66737P600 | 3,278 | 978,359 | SH | | DFND | 1 | 0 | 978,359 | 0 |
| NOVAVAX INC | COM | 670002104 | 2,765 | 875,000 | SH | | DFND | 1 | 0 | 875,000 | 0 |
| NUPATHE INC | COM | 67059M950 | 369 | 1,531 | SH | Put | DFND | 1 | 0 | 1,531 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A106 | 3,806 | 410,577 | SH | | DFND | 1 | 0 | 410,577 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A956 | 1,527 | 1,647 | SH | Put | DFND | 1 | 0 | 1,647 | 0 |
| ONCOLYTICS BIOTECH INC | COM | 682310907 | 24 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| ONCOTHYREON INC | COM | 682324108 | 1,359 | 659,600 | SH | | DFND | 1 | 0 | 659,600 | 0 |
| ONCOTHYREON INC | COM | 682324908 | 230 | 1,116 | SH | Call | DFND | 1 | 0 | 1,116 | 0 |
| ONYX PHARMACEUTICALS INC | COM | 683399109 | 504 | 4,045 | SH | | DFND | 1 | 0 | 4,045 | 0 |
| ONYX PHARMACEUTICALS INC | COM | 683399909 | 2,481 | 199 | SH | Call | DFND | 1 | 0 | 199 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 16,767 | 19,032 | SH | Call | DFND | 1 | 0 | 19,032 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 6,027 | 6,841 | SH | Put | DFND | 1 | 0 | 6,841 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164904 | 3,741 | 6,093 | SH | Call | DFND | 1 | 0 | 6,093 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164954 | 345 | 562 | SH | Put | DFND | 1 | 0 | 562 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 1,605 | 162,000 | SH | | DFND | 1 | 0 | 162,000 | 0 |
| OXYGEN BIOTHERAPEUTICS INC | COM | 69207P308 | 54 | 36,715 | SH | | DFND | 1 | 0 | 36,715 | 0 |
| PBF ENERGY INC | CL A | 69318G906 | 4,479 | 1,995 | SH | Call | DFND | 1 | 0 | 1,995 | 0 |
| PHARMACYCLICS INC | COM | 716933106 | 1,709 | 12,350 | SH | | DFND | 1 | 0 | 12,350 | 0 |
| PHARMACYCLICS INC | COM | 716933906 | 6,229 | 450 | SH | Call | DFND | 1 | 0 | 450 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 2,146 | 155 | SH | Put | DFND | 1 | 0 | 155 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 351 | 1,038 | SH | Put | DFND | 1 | 0 | 1,038 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 31,318 | 1,001 | SH | Call | DFND | 1 | 0 | 1,001 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F957 | 5,694 | 182 | SH | Put | DFND | 1 | 0 | 182 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H209 | 3,961 | 147,783 | SH | | DFND | 1 | 0 | 147,783 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H909 | 2,318 | 865 | SH | Call | DFND | 1 | 0 | 865 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 15,362 | 5,732 | SH | Put | DFND | 1 | 0 | 5,732 | 0 |
| REXAHN PHARMACEUTICALS INC | COM | 761640101 | 1,013 | 2,250,840 | SH | | DFND | 1 | 0 | 2,250,840 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559603 | 710 | 198,259 | SH | | DFND | 1 | 0 | 198,259 | 0 |
| SALIX PHARMACEUTICALS LTD | COM | 795435106 | 473 | 7,073 | SH | | DFND | 1 | 0 | 7,073 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 24,656 | 522,041 | SH | | DFND | 1 | 0 | 522,041 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 12,795 | 2,709 | SH | Call | DFND | 1 | 0 | 2,709 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 61,531 | 13,028 | SH | Put | DFND | 1 | 0 | 13,028 | 0 |
| SEQUENOM INC | COM | 817337405 | 41 | 15,400 | SH | | DFND | 1 | 0 | 15,400 | 0 |
| SEQUENOM INC | COM | 817337905 | 78 | 293 | SH | Call | DFND | 1 | 0 | 293 | 0 |
| SEQUENOM INC | COM | 817337955 | 55 | 205 | SH | Put | DFND | 1 | 0 | 205 | 0 |
| SOLAZYME INC | COM | 83415T101 | 2,136 | 198,350 | SH | | DFND | 1 | 0 | 198,350 | 0 |
| SOLAZYME INC | COM | 83415T950 | 2,115 | 1,964 | SH | Put | DFND | 1 | 0 | 1,964 | 0 |
| SPDR S&P 500 ETF TRUST TRUST UNITS | UNIT | 78462F953 | 37,823 | 2,250 | SH | Put | DFND | 1 | 0 | 2,250 | 0 |
| SUPERCONDUCTOR TECHNOLOGIES | COM | 867931404 | 1,004 | 619,600 | SH | | DFND | 1 | 0 | 619,600 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A903 | 5,825 | 920 | SH | Call | DFND | 1 | 0 | 920 | 0 |
| SYNTA PHARMACEUTICALS CORP | COM | 87162T206 | 1,584 | 250,952 | SH | | DFND | 1 | 0 | 250,952 | 0 |
| SYNTA PHARMACEUTICALS CORP | COM | 87162T906 | 791 | 1,253 | SH | Call | DFND | 1 | 0 | 1,253 | 0 |
| SYNTA PHARMACEUTICALS CORP | COM | 87162T956 | 1,887 | 2,991 | SH | Put | DFND | 1 | 0 | 2,991 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | COM | 881624209 | 1,081 | 28,603 | SH | | DFND | 1 | 0 | 28,603 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | COM | 881624909 | 2,520 | 667 | SH | Call | DFND | 1 | 0 | 667 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | COM | 881624959 | 3,589 | 950 | SH | Put | DFND | 1 | 0 | 950 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 | 1,402 | 275,479 | SH | | DFND | 1 | 0 | 275,479 | 0 |
| THERAVANCE INC | COM | 88338T904 | 2,380 | 582 | SH | Call | DFND | 1 | 0 | 582 | 0 |
| TONIX PHARMACEUTICALS HOLDING | COM | 890110109 | 1,024 | 288,454 | SH | | DFND | 1 | 0 | 288,454 | 0 |
| TRANSCEPT PHARMACEUTICALS INC | COM | 89354M106 | 552 | 173,500 | SH | | DFND | 1 | 0 | 173,500 | 0 |
| TRANSCEPT PHARMACEUTICALS INC | COM | 89354M956 | 551 | 1,733 | SH | Put | DFND | 1 | 0 | 1,733 | 0 |
| UNI-PIXEL INC | COM | 904572903 | 1,200 | 677 | SH | Call | DFND | 1 | 0 | 677 | 0 |
| UNI-PIXEL INC | COM | 904572953 | 1,769 | 998 | SH | Put | DFND | 1 | 0 | 998 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 1,325 | 168 | SH | Call | DFND | 1 | 0 | 168 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659908 | 2,004 | 1,827 | SH | Call | DFND | 1 | 0 | 1,827 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659958 | 1,662 | 1,515 | SH | Put | DFND | 1 | 0 | 1,515 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 25,548 | 336,955 | SH | | DFND | 1 | 0 | 336,955 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 188,716 | 24,890 | SH | Call | DFND | 1 | 0 | 24,890 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 49,670 | 6,551 | SH | Put | DFND | 1 | 0 | 6,551 | 0 |
| VICAL INC | COM | 925602104 | 727 | 581,595 | SH | | DFND | 1 | 0 | 581,595 | 0 |
| VIVUS INC | COM | 928551900 | 722 | 775 | SH | Call | DFND | 1 | 0 | 775 | 0 |
| VIVUS INC | COM | 928551950 | 572 | 614 | SH | Put | DFND | 1 | 0 | 614 | 0 |
| WELLCARE HEALTH PLANS INC | COM | 94946T906 | 12,979 | 1,861 | SH | Call | DFND | 1 | 0 | 1,861 | 0 |
| XOMA CORP | COM | 98419J107 | 2,041 | 455,672 | SH | | DFND | 1 | 0 | 455,672 | 0 |
| XOMA CORP | COM | 98419J957 | 742 | 1,656 | SH | Put | DFND | 1 | 0 | 1,656 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P901 | 972 | 2,462 | SH | Call | DFND | 1 | 0 | 2,462 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P951 | 712 | 1,803 | SH | Put | DFND | 1 | 0 | 1,803 | 0 |
