| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y109 | 2,730 | 517 | SH | Call | DFND | 1 | 0 | 517 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 13,920 | 557,013 | SH | | DFND | 1 | 0 | 557,013 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225909 | 74,628 | 29,863 | SH | Call | DFND | 1 | 0 | 29,863 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225959 | 1,422 | 569 | SH | Put | DFND | 1 | 0 | 569 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 903 | 79,833 | SH | | DFND | 1 | 0 | 79,833 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T900 | 580 | 513 | SH | Call | DFND | 1 | 0 | 513 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 1,505 | 453,380 | SH | | DFND | 1 | 0 | 453,380 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 7,496 | 22,579 | SH | Call | DFND | 1 | 0 | 22,579 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 495 | 1,491 | SH | Put | DFND | 1 | 0 | 1,491 | 0 |
| ADAMIS PHARMACEUTICALS CORP | COM | 00547W208 | 2,601 | 407,024 | SH | | DFND | 1 | 0 | 407,024 | 0 |
| ADVAXIS INC-CW18 | WAR | 007624117 | 276 | 162,375 | SH | | DFND | 1 | 0 | 162,375 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 8,276 | 116,626 | SH | | DFND | 1 | 0 | 116,626 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E902 | 9,757 | 1,375 | SH | Call | DFND | 1 | 0 | 1,375 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E952 | 12,915 | 1,820 | SH | Put | DFND | 1 | 0 | 1,820 | 0 |
| AGENUS INC | COM | 00847G905 | 79 | 301 | SH | Call | DFND | 1 | 0 | 301 | 0 |
| ALCOBRA LTD | SHS | M2239P109 | 2,278 | 126,629 | SH | | DFND | 1 | 0 | 126,629 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351909 | 5,176 | 389 | SH | Call | DFND | 1 | 0 | 389 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384909 | 965 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALLERGAN INC | COM | 018490902 | 62,083 | 5,589 | SH | Call | DFND | 1 | 0 | 5,589 | 0 |
| ALLERGAN INC | COM | 018490952 | 17,951 | 1,616 | SH | Put | DFND | 1 | 0 | 1,616 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111206 | 204 | 103,800 | SH | | DFND | 1 | 0 | 103,800 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111906 | 588 | 2,986 | SH | Call | DFND | 1 | 0 | 2,986 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111956 | 38 | 193 | SH | Put | DFND | 1 | 0 | 193 | 0 |
| AMBIT BIOSCIENCES CORP | COM | 02318X100 | 627 | 65,000 | SH | | DFND | 1 | 0 | 65,000 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T109 | 162 | 22,758 | SH | | DFND | 1 | 0 | 22,758 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T959 | 275 | 386 | SH | Put | DFND | 1 | 0 | 386 | 0 |
| ANI PHARMACEUTICALS INC | COM | 00182C103 | 24 | 1,219 | SH | | DFND | 1 | 0 | 1,219 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U201 | 5,265 | 1,714,958 | SH | | DFND | 1 | 0 | 1,714,958 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U901 | 94 | 307 | SH | Call | DFND | 1 | 0 | 307 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V109 | 28 | 10,638 | SH | | DFND | 1 | 0 | 10,638 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V959 | 281 | 1,060 | SH | Put | DFND | 1 | 0 | 1,060 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 5,371 | 9,181 | SH | Call | DFND | 1 | 0 | 9,181 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 4,283 | 7,322 | SH | Put | DFND | 1 | 0 | 7,322 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 3,328 | 4,880 | SH | Call | DFND | 1 | 0 | 4,880 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 1,575 | 2,309 | SH | Put | DFND | 1 | 0 | 2,309 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797909 | 1,352 | 1,246 | SH | Call | DFND | 1 | 0 | 1,246 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797959 | 971 | 895 | SH | Put | DFND | 1 | 0 | 895 | 0 |
| ATHERSYS INC | COM | 04744L906 | 89 | 354 | SH | Call | DFND | 1 | 0 | 354 | 0 |
| ATHERSYS INC | COM | 04744L956 | 119 | 477 | SH | Put | DFND | 1 | 0 | 477 | 0 |
| AVANIR PHARMACEUTICALS INC | COM | 05348P401 | 381 | 113,308 | SH | | DFND | 1 | 0 | 113,308 | 0 |
| AVANIR PHARMACEUTICALS INC | COM | 05348P901 | 559 | 1,663 | SH | Call | DFND | 1 | 0 | 1,663 | 0 |
| AVANIR PHARMACEUTICALS INC | COM | 05348P951 | 1,097 | 3,264 | SH | Put | DFND | 1 | 0 | 3,264 | 0 |
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 2,742 | 1,490,121 | SH | | DFND | 1 | 0 | 1,490,121 | 0 |
| BAXTER INTERNATIONAL INC | COM | 071813109 | 15,009 | 2,158 | SH | Call | DFND | 1 | 0 | 2,158 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V903 | 1,198 | 1,576 | SH | Call | DFND | 1 | 0 | 1,576 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V953 | 602 | 792 | SH | Put | DFND | 1 | 0 | 792 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 25,261 | 903 | SH | Call | DFND | 1 | 0 | 903 | 0 |
| BIOGEN IDEC INC | COM | 09062X953 | 6,099 | 218 | SH | Put | DFND | 1 | 0 | 218 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 2,141 | 102,035 | SH | | DFND | 1 | 0 | 102,035 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 50,455 | 9,493 | SH | Call | DFND | 1 | 0 | 9,493 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122958 | 1,233 | 232 | SH | Put | DFND | 1 | 0 | 232 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 2,181 | 679,592 | SH | | DFND | 1 | 0 | 679,592 | 0 |
| CELGENE CORP | COM | 151020904 | 3,548 | 210 | SH | Call | DFND | 1 | 0 | 210 | 0 |
| CELGENE CORP | COM | 151020954 | 10,949 | 648 | SH | Put | DFND | 1 | 0 | 648 | 0 |
| CELLDEX THERAPEUTICS INC | COM | 15117B903 | 8,188 | 3,382 | SH | Call | DFND | 1 | 0 | 3,382 | 0 |
| CELLDEX THERAPEUTICS INC | COM | 15117B953 | 1,666 | 688 | SH | Put | DFND | 1 | 0 | 688 | 0 |
| CEL-SCI CORP | COM | 150837508 | 983 | 1,662,788 | SH | | DFND | 1 | 0 | 1,662,788 | 0 |
| CELSION CORPORATION | COM | 15117N904 | 2,330 | 5,990 | SH | Call | DFND | 1 | 0 | 5,990 | 0 |
| CELSION CORPORATION | COM | 15117N954 | 3,643 | 9,364 | SH | Put | DFND | 1 | 0 | 9,364 | 0 |
| CEMPRA INC | COM | 15130J109 | 2,936 | 237,000 | SH | | DFND | 1 | 0 | 237,000 | 0 |
| CHELSEA THERAPEUTICS INTERNATIONAL LTD | COM | 163428105 | 369 | 83,200 | SH | | DFND | 1 | 0 | 83,200 | 0 |
| CHELSEA THERAPEUTICS INTERNATIONAL LTD | COM | 163428955 | 1,113 | 2,509 | SH | Put | DFND | 1 | 0 | 2,509 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464900 | 205 | 34 | SH | Call | DFND | 1 | 0 | 34 | 0 |
| CONATUS PHARMACEUTICALS INC | COM | 20600T108 | 683 | 105,860 | SH | | DFND | 1 | 0 | 105,860 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678907 | 2,591 | 1,329 | SH | Call | DFND | 1 | 0 | 1,329 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678957 | 23,209 | 3,370 | SH | Put | DFND | 1 | 0 | 3,370 | 0 |
| CYTOKINETICS INC | COM | 23282W905 | 138 | 212 | SH | Call | DFND | 1 | 0 | 212 | 0 |
| CYTRX CORP | COM | 232828509 | 78 | 125 | SH | Call | DFND | 1 | 0 | 125 | 0 |
| DELCATH SYSTEMS INC | COM | 24661P104 | 1,593 | 6,246,652 | SH | | DFND | 1 | 0 | 6,246,652 | 0 |
| DENDREON CORP | COM | 24823Q107 | 393 | 131,500 | SH | | DFND | 1 | 0 | 131,500 | 0 |
| DENDREON CORP | COM | 24823Q957 | 429 | 1,436 | SH | Put | DFND | 1 | 0 | 1,436 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668403 | 1,350 | 600,000 | SH | | DFND | 1 | 0 | 600,000 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668903 | 23 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| DYAX CORP | COM | 26746E103 | 1,028 | 136,581 | SH | | DFND | 1 | 0 | 136,581 | 0 |
| DYAX CORP | COM | 26746E903 | 179 | 238 | SH | Call | DFND | 1 | 0 | 238 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158102 | 980 | 500,000 | SH | | DFND | 1 | 0 | 500,000 | 0 |
| EDAP TMS SA -ADR | ADR | 268311107 | 2,289 | 770,618 | SH | | DFND | 1 | 0 | 770,618 | 0 |
| EDWARDS LIFESCIENCES CORP | COM | 28176E908 | 11,166 | 1,698 | SH | Call | DFND | 1 | 0 | 1,698 | 0 |
| ELI LILLY & CO | COM | 532457108 | 2,076 | 40,700 | SH | | DFND | 1 | 0 | 40,700 | 0 |
| ELI LILLY & CO | COM | 532457958 | 2,076 | 407 | SH | Put | DFND | 1 | 0 | 407 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M106 | 2,345 | 85,946 | SH | | DFND | 1 | 0 | 85,946 | 0 |
| ENDOCYTE INC | COM | 29269A102 | 597 | 55,849 | SH | | DFND | 1 | 0 | 55,849 | 0 |
| ENDOCYTE INC | COM | 29269A902 | 114 | 107 | SH | Call | DFND | 1 | 0 | 107 | 0 |
| ENDOCYTE INC | COM | 29269A952 | 973 | 910 | SH | Put | DFND | 1 | 0 | 910 | 0 |
| ENTREMED INC | COM | 29382F202 | 2,206 | 1,289,929 | SH | | DFND | 1 | 0 | 1,289,929 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 | 464 | 39,729 | SH | | DFND | 1 | 0 | 39,729 | 0 |
| EXACT SCIENCES CORP | COM | 30063P905 | 1,198 | 1,025 | SH | Call | DFND | 1 | 0 | 1,025 | 0 |
| EXACT SCIENCES CORP | COM | 30063P955 | 1,631 | 1,395 | SH | Put | DFND | 1 | 0 | 1,395 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 2,427 | 3,960 | SH | Call | DFND | 1 | 0 | 3,960 | 0 |
| EXELIXIS INC | COM | 30161Q954 | 214 | 349 | SH | Put | DFND | 1 | 0 | 349 | 0 |
| FIBROCELL SCIENCE INC | COM | 315721209 | 363 | 89,500 | SH | | DFND | 1 | 0 | 89,500 | 0 |
| GALENA BIOPHARMA INC | COM | 363256908 | 709 | 1,430 | SH | Call | DFND | 1 | 0 | 1,430 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 4,524 | 9,121 | SH | Put | DFND | 1 | 0 | 9,121 | 0 |
| GERON CORP | COM | 374163103 | 133 | 28,013 | SH | | DFND | 1 | 0 | 28,013 | 0 |
| GEVO INC | COM | 374396109 | 663 | 463,552 | SH | | DFND | 1 | 0 | 463,552 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 5,862 | 78,000 | SH | | DFND | 1 | 0 | 78,000 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 15,030 | 2,000 | SH | Call | DFND | 1 | 0 | 2,000 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 51,162 | 6,808 | SH | Put | DFND | 1 | 0 | 6,808 | 0 |
| GLAXOSMITHKLINE PLC | ADR | 37733W905 | 33,636 | 6,300 | SH | Call | DFND | 1 | 0 | 6,300 | 0 |
| GLAXOSMITHKLINE PLC | ADR | 37733W955 | 470 | 88 | SH | Put | DFND | 1 | 0 | 88 | 0 |
| HALOZYME THERAPEUTICS INC | COM | 40637H909 | 1,049 | 700 | SH | Call | DFND | 1 | 0 | 700 | 0 |
| HORIZON PHARMA INC | COM | 44047T959 | 85 | 111 | SH | Put | DFND | 1 | 0 | 111 | 0 |
| IDENIX PHARMACEUTICALS INC | COM | 45166R904 | 761 | 1,273 | SH | Call | DFND | 1 | 0 | 1,273 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536105 | 23 | 25,000 | SH | | DFND | 1 | 0 | 25,000 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536955 | 426 | 3,737 | SH | Put | DFND | 1 | 0 | 3,737 | 0 |
| INCYTE CORP | COM | 45337C902 | 2,182 | 431 | SH | Call | DFND | 1 | 0 | 431 | 0 |
| INCYTE CORP | COM | 45337C952 | 947 | 187 | SH | Put | DFND | 1 | 0 | 187 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 967 | 70,000 | SH | | DFND | 1 | 0 | 70,000 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G903 | 702 | 508 | SH | Call | DFND | 1 | 0 | 508 | 0 |
| INSMED INC | COM | 457669907 | 3,387 | 1,991 | SH | Call | DFND | 1 | 0 | 1,991 | 0 |
| INSMED INC | COM | 457669957 | 2,938 | 1,727 | SH | Put | DFND | 1 | 0 | 1,727 | 0 |
| INTERMUNE INC | COM | 45884X903 | 6,175 | 4,192 | SH | Call | DFND | 1 | 0 | 4,192 | 0 |
| INTERMUNE INC | COM | 45884X953 | 2,707 | 1,838 | SH | Put | DFND | 1 | 0 | 1,838 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287905 | 57,655 | 5,000 | SH | Call | DFND | 1 | 0 | 5,000 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 23,062 | 2,000 | SH | Put | DFND | 1 | 0 | 2,000 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330109 | 524 | 13,157 | SH | | DFND | 1 | 0 | 13,157 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330909 | 518 | 130 | SH | Call | DFND | 1 | 0 | 130 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330959 | 9,307 | 2,336 | SH | Put | DFND | 1 | 0 | 2,336 | 0 |
| ISORAY INC | COM | 46489V104 | 311 | 621,526 | SH | | DFND | 1 | 0 | 621,526 | 0 |
| KALOBIOS PHARMACEUTICALS INC | COM | 48344T100 | 356 | 80,650 | SH | | DFND | 1 | 0 | 80,650 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515901 | 13,140 | 10,147 | SH | Call | DFND | 1 | 0 | 10,147 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 767 | 592 | SH | Put | DFND | 1 | 0 | 592 | 0 |
| KYTHERA BIOPHARMACEUTICALS INC | COM | 501570105 | 2,466 | 66,200 | SH | | DFND | 1 | 0 | 66,200 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 1,800 | 1,000,000 | SH | | DFND | 1 | 0 | 1,000,000 | 0 |
| LIGAND PHARMACEUTICALS INC | COM | 53220K904 | 8,106 | 1,541 | SH | Call | DFND | 1 | 0 | 1,541 | 0 |
| MANNKIND CORP | COM | 56400P201 | 20,485 | 3,931,850 | SH | | DFND | 1 | 0 | 3,931,850 | 0 |
| MANNKIND CORP | COM | 56400P901 | 15,938 | 30,592 | SH | Call | DFND | 1 | 0 | 30,592 | 0 |
| MANNKIND CORP | COM | 56400P951 | 8,689 | 16,678 | SH | Put | DFND | 1 | 0 | 16,678 | 0 |
| MEDIVATION INC | COM | 58501N101 | 4,788 | 75,016 | SH | | DFND | 1 | 0 | 75,016 | 0 |
| MEDIVATION INC | COM | 58501N951 | 31,387 | 4,918 | SH | Put | DFND | 1 | 0 | 4,918 | 0 |
| MEI PHARMA INC | COM | 55279B202 | 1,105 | 138,000 | SH | | DFND | 1 | 0 | 138,000 | 0 |
| MEI PHARMA INC | COM | 55279B902 | 216 | 270 | SH | Call | DFND | 1 | 0 | 270 | 0 |
| MELA SCIENCES INC | COM | 55277R100 | 2,746 | 4,290,716 | SH | | DFND | 1 | 0 | 4,290,716 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 64,224 | 12,832 | SH | Call | DFND | 1 | 0 | 12,832 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 203 | 12,213 | SH | | DFND | 1 | 0 | 12,213 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T900 | 4,574 | 2,587 | SH | Call | DFND | 1 | 0 | 2,587 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T950 | 233 | 132 | SH | Put | DFND | 1 | 0 | 132 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 6 | 500 | SH | | DFND | 1 | 0 | 500 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268958 | 182 | 160 | SH | Put | DFND | 1 | 0 | 160 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 1,221 | 1,307 | SH | Call | DFND | 1 | 0 | 1,307 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 10,739 | 4,879 | SH | Call | DFND | 1 | 0 | 4,879 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P900 | 44 | 118 | SH | Call | DFND | 1 | 0 | 118 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 683 | 1,812 | SH | Put | DFND | 1 | 0 | 1,812 | 0 |
| NOVAVAX INC | COM | 670002104 | 154 | 30,000 | SH | | DFND | 1 | 0 | 30,000 | 0 |
| NOVAVAX INC | COM | 670002954 | 984 | 1,922 | SH | Put | DFND | 1 | 0 | 1,922 | 0 |
| NUPATHE INC | COM | 67059M100 | 293 | 89,751 | SH | | DFND | 1 | 0 | 89,751 | 0 |
| NUPATHE INC | COM | 67059M950 | 2,294 | 7,014 | SH | Put | DFND | 1 | 0 | 7,014 | 0 |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 779 | 59,984 | SH | | DFND | 1 | 0 | 59,984 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A106 | 2,942 | 352,800 | SH | | DFND | 1 | 0 | 352,800 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A906 | 231 | 277 | SH | Call | DFND | 1 | 0 | 277 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A956 | 105 | 126 | SH | Put | DFND | 1 | 0 | 126 | 0 |
| ONCOTHYREON INC | COM | 682324108 | 1,264 | 718,000 | SH | | DFND | 1 | 0 | 718,000 | 0 |
| ONCOTHYREON INC | COM | 682324908 | 120 | 679 | SH | Call | DFND | 1 | 0 | 679 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 16,507 | 19,558 | SH | Call | DFND | 1 | 0 | 19,558 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 7,956 | 9,427 | SH | Put | DFND | 1 | 0 | 9,427 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164904 | 1,273 | 2,261 | SH | Call | DFND | 1 | 0 | 2,261 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164954 | 68 | 120 | SH | Put | DFND | 1 | 0 | 120 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 1,392 | 152,336 | SH | | DFND | 1 | 0 | 152,336 | 0 |
| OXIGENE INC | COM | 691828404 | 871 | 345,658 | SH | | DFND | 1 | 0 | 345,658 | 0 |
| PHARMACYCLICS INC | COM | 716933106 | 303 | 2,860 | SH | | DFND | 1 | 0 | 2,860 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 772 | 73 | SH | Put | DFND | 1 | 0 | 73 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 353 | 1,003 | SH | Put | DFND | 1 | 0 | 1,003 | 0 |
| PRANA BIOTECHNOLOGY LTD | ADR | 739727905 | 321 | 458 | SH | Call | DFND | 1 | 0 | 458 | 0 |
| PROGENICS PHARMACEUTICALS INC | COM | 743187956 | 159 | 298 | SH | Put | DFND | 1 | 0 | 298 | 0 |
| PROSENSA HOLDING N.V. | SHS | N71546950 | 56 | 120 | SH | Put | DFND | 1 | 0 | 120 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 | 504 | 19,000 | SH | | DFND | 1 | 0 | 19,000 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V907 | 1,988 | 192 | SH | Call | DFND | 1 | 0 | 192 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 17,946 | 652 | SH | Call | DFND | 1 | 0 | 652 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F957 | 275 | 10 | SH | Put | DFND | 1 | 0 | 10 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H909 | 485 | 265 | SH | Call | DFND | 1 | 0 | 265 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 5,371 | 2,935 | SH | Put | DFND | 1 | 0 | 2,935 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559603 | 2,174 | 762,900 | SH | | DFND | 1 | 0 | 762,900 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 2,171 | 1,976 | SH | Put | DFND | 1 | 0 | 1,976 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 10,342 | 507,700 | SH | | DFND | 1 | 0 | 507,700 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 4,292 | 2,107 | SH | Call | DFND | 1 | 0 | 2,107 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 15,223 | 7,473 | SH | Put | DFND | 1 | 0 | 7,473 | 0 |
| SEQUENOM INC | COM | 817337405 | 48 | 20,500 | SH | | DFND | 1 | 0 | 20,500 | 0 |
| SEQUENOM INC | COM | 817337905 | 69 | 293 | SH | Call | DFND | 1 | 0 | 293 | 0 |
| SEQUENOM INC | COM | 817337955 | 48 | 205 | SH | Put | DFND | 1 | 0 | 205 | 0 |
| SORRENTO THERAPEUTICS INC | COM | 83587F202 | 1,798 | 222,026 | SH | | DFND | 1 | 0 | 222,026 | 0 |
| SPDR S&P 500 ETF TRUST | ETF | 78462F903 | 164,966 | 8,933 | SH | Call | DFND | 1 | 0 | 8,933 | 0 |
| SPDR S&P 500 ETF TRUST | ETF | 78462F953 | 24,709 | 1,338 | SH | Put | DFND | 1 | 0 | 1,338 | 0 |
| SPDR S&P BIOTECHNOLOGY | ETF | 78464A950 | 28,175 | 2,164 | SH | Put | DFND | 1 | 0 | 2,164 | 0 |
| STAAR SURGICAL CO | COM | 852312905 | 1,094 | 676 | SH | Call | DFND | 1 | 0 | 676 | 0 |
| STAAR SURGICAL CO | COM | 852312955 | 314 | 194 | SH | Put | DFND | 1 | 0 | 194 | 0 |
| STEMCELLS INC | COM | 85857R204 | 1,041 | 846,622 | SH | | DFND | 1 | 0 | 846,622 | 0 |
| STEMLINE THERAPEUTICS INC | COM | 85858C107 | 1,335 | 68,100 | SH | | DFND | 1 | 0 | 68,100 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328601 | 530 | 111,847 | SH | | DFND | 1 | 0 | 111,847 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328901 | 672 | 1,418 | SH | Call | DFND | 1 | 0 | 1,418 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328951 | 360 | 760 | SH | Put | DFND | 1 | 0 | 760 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A903 | 1,845 | 285 | SH | Call | DFND | 1 | 0 | 285 | 0 |
| SYNERGY PHARMACEUTICALS-CW16 | WAR | 871639118 | 751 | 349,217 | SH | | DFND | 1 | 0 | 349,217 | 0 |
| TARGACEPT INC | COM | 87611R306 | 148 | 35,761 | SH | | DFND | 1 | 0 | 35,761 | 0 |
| TARGACEPT INC | COM | 87611R906 | 187 | 451 | SH | Call | DFND | 1 | 0 | 451 | 0 |
| TEKMIRA PHARMACEUTICALS CORP | COM | 87911B209 | 4,138 | 519,200 | SH | | DFND | 1 | 0 | 519,200 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624209 | 18,690 | 466,312 | SH | | DFND | 1 | 0 | 466,312 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 2,673 | 667 | SH | Call | DFND | 1 | 0 | 667 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 34,088 | 8,505 | SH | Put | DFND | 1 | 0 | 8,505 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 | 257 | 66,000 | SH | | DFND | 1 | 0 | 66,000 | 0 |
| THERAVANCE INC | COM | 88338T904 | 809 | 227 | SH | Call | DFND | 1 | 0 | 227 | 0 |
| TRANSCEPT PHARMACEUTICALS INC | COM | 89354M106 | 945 | 281,330 | SH | | DFND | 1 | 0 | 281,330 | 0 |
| TROVAGENE INC | COM | 897238309 | 115 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| TWITTER INC | COM | 90184L102 | 4,602 | 72,300 | SH | | DFND | 1 | 0 | 72,300 | 0 |
| TWITTER INC | COM | 90184L952 | 395 | 62 | SH | Put | DFND | 1 | 0 | 62 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 1,816 | 146,350 | SH | | DFND | 1 | 0 | 146,350 | 0 |
| VENTRUS BIOSCIENCES INC | COM | 922822951 | 61 | 160 | SH | Put | DFND | 1 | 0 | 160 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 198,091 | 26,661 | SH | Call | DFND | 1 | 0 | 26,661 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 72,576 | 9,768 | SH | Put | DFND | 1 | 0 | 9,768 | 0 |
| VIVUS INC | COM | 928551900 | 342 | 377 | SH | Call | DFND | 1 | 0 | 377 | 0 |
| VIVUS INC | COM | 928551950 | 1,450 | 1,597 | SH | Put | DFND | 1 | 0 | 1,597 | 0 |
| WELLCARE HEALTH PLANS INC | COM | 94946T906 | 14,661 | 2,082 | SH | Call | DFND | 1 | 0 | 2,082 | 0 |
| WELLCARE HEALTH PLANS INC | COM | 94946T956 | 282 | 40 | SH | Put | DFND | 1 | 0 | 40 | 0 |
| XOMA CORP | COM | 98419J107 | 2,782 | 413,390 | SH | | DFND | 1 | 0 | 413,390 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P901 | 1,118 | 2,577 | SH | Call | DFND | 1 | 0 | 2,577 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P951 | 1,114 | 2,567 | SH | Put | DFND | 1 | 0 | 2,567 | 0 |
| ZOGENIX INC | COM | 98978L105 | 882 | 256,500 | SH | | DFND | 1 | 0 | 256,500 | 0 |
