| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y909 | 38,730 | 7,535 | SH | Call | DFND | 1 | 0 | 7,535 | 0 |
| ABBVIE INC | COM | 00287Y959 | 15,312 | 2,979 | SH | Put | DFND | 1 | 0 | 2,979 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 11,268 | 463,146 | SH | | DFND | 1 | 0 | 463,146 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 64,929 | 26,687 | SH | Call | DFND | 1 | 0 | 26,687 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225958 | 810 | 333 | SH | Put | DFND | 1 | 0 | 333 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 556 | 46,316 | SH | | DFND | 1 | 0 | 46,316 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T900 | 563 | 469 | SH | Call | DFND | 1 | 0 | 469 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T950 | 2,789 | 2,322 | SH | Put | DFND | 1 | 0 | 2,322 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 4,834 | 14,693 | SH | Call | DFND | 1 | 0 | 14,693 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 376 | 1,142 | SH | Put | DFND | 1 | 0 | 1,142 | 0 |
| ADAMIS PHARMACEUTICALS CORP | COM | 00547W208 | 386 | 60,767 | SH | | DFND | 1 | 0 | 60,767 | 0 |
| ADVAXIS INC | WAR | 007624117 | 181 | 144,935 | SH | | DFND | 1 | 0 | 144,935 | 0 |
| ADVAXIS INC | COM | 007624958 | 314 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 1,587 | 34,420 | SH | | DFND | 1 | 0 | 34,420 | 0 |
| AGENUS INC | COM | 00847G705 | 589 | 185,830 | SH | | DFND | 1 | 0 | 185,830 | 0 |
| AGENUS INC | COM | 00847G905 | 477 | 1,506 | SH | Call | DFND | 1 | 0 | 1,506 | 0 |
| AGENUS INC | COM | 00847G955 | 78 | 245 | SH | Put | DFND | 1 | 0 | 245 | 0 |
| ALEXZA PHARMACEUTICALS INC SHS | COM | 015384909 | 904 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALIMERA SCIENCES INC | COM | 016259103 | 3,945 | 500,000 | SH | | DFND | 1 | 0 | 500,000 | 0 |
| ALIMERA SCIENCES INC | COM | 016259953 | 820 | 1,039 | SH | Put | DFND | 1 | 0 | 1,039 | 0 |
| ALKERMES PLC | SHS | G01767105 | 226 | 5,126 | SH | | DFND | 1 | 0 | 5,126 | 0 |
| ALKERMES PLC | SHS | G01767905 | 763 | 173 | SH | Call | DFND | 1 | 0 | 173 | 0 |
| ALKERMES PLC | SHS | G01767955 | 683 | 155 | SH | Put | DFND | 1 | 0 | 155 | 0 |
| ALLERGAN INC | COM | 018490902 | 44,105 | 3,554 | SH | Call | DFND | 1 | 0 | 3,554 | 0 |
| ALLERGAN INC | COM | 018490952 | 10,710 | 863 | SH | Put | DFND | 1 | 0 | 863 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111206 | 2,392 | 1,321,622 | SH | | DFND | 1 | 0 | 1,321,622 | 0 |
| AMARIN CORPORATION PLC -ADR | ADR | 023111906 | 36 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| AMGEN INC | COM | 031162100 | 5,219 | 42,311 | SH | | DFND | 1 | 0 | 42,311 | 0 |
| AMGEN INC | COM | 031162950 | 14,036 | 1,138 | SH | Put | DFND | 1 | 0 | 1,138 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T109 | 260 | 41,000 | SH | | DFND | 1 | 0 | 41,000 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T959 | 1,064 | 1,676 | SH | Put | DFND | 1 | 0 | 1,676 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U201 | 2,305 | 688,037 | SH | | DFND | 1 | 0 | 688,037 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U901 | 108 | 322 | SH | Call | DFND | 1 | 0 | 322 | 0 |
| APPLE INC | COM | 037833900 | 31,077 | 579 | SH | Call | DFND | 1 | 0 | 579 | 0 |
| APPLE INC | COM | 037833950 | 31,077 | 579 | SH | Put | DFND | 1 | 0 | 579 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V109 | 27 | 12,503 | SH | | DFND | 1 | 0 | 12,503 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V959 | 313 | 1,457 | SH | Put | DFND | 1 | 0 | 1,457 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047102 | 1,359 | 215,700 | SH | | DFND | 1 | 0 | 215,700 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 1,736 | 2,756 | SH | Put | DFND | 1 | 0 | 2,756 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 5,819 | 7,220 | SH | Call | DFND | 1 | 0 | 7,220 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 4,821 | 5,981 | SH | Put | DFND | 1 | 0 | 5,981 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797909 | 1,686 | 1,027 | SH | Call | DFND | 1 | 0 | 1,027 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797959 | 4,069 | 2,478 | SH | Put | DFND | 1 | 0 | 2,478 | 0 |
| ATHERSYS INC | COM | 04744L906 | 191 | 588 | SH | Call | DFND | 1 | 0 | 588 | 0 |
| ATHERSYS INC | COM | 04744L956 | 339 | 1,045 | SH | Put | DFND | 1 | 0 | 1,045 | 0 |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D907 | 10,826 | 3,983 | SH | Call | DFND | 1 | 0 | 3,983 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P901 | 1,835 | 5,000 | SH | Call | DFND | 1 | 0 | 5,000 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P951 | 1,376 | 3,750 | SH | Put | DFND | 1 | 0 | 3,750 | 0 |
| AVEO PHARMACEUTICALS INC | COM | 053588109 | 857 | 573,416 | SH | | DFND | 1 | 0 | 573,416 | 0 |
| BIO PATH HOLDINGS INC | COM | 09057N102 | 8,781 | 3,313,600 | SH | | DFND | 1 | 0 | 3,313,600 | 0 |
| BIODEL INC | COM | 09064M954 | 50 | 182 | SH | Put | DFND | 1 | 0 | 182 | 0 |
| BIODELIVERY SCIENCES INTERNATIONAL INC | COM | 09060J956 | 3,335 | 3,952 | SH | Put | DFND | 1 | 0 | 3,952 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 63,468 | 2,075 | SH | Call | DFND | 1 | 0 | 2,075 | 0 |
| BIOGEN IDEC INC | COM | 09062X953 | 1,529 | 50 | SH | Put | DFND | 1 | 0 | 50 | 0 |
| BIOLINERX LTD-SPONS ADR | ADR | 09071M106 | 4,243 | 1,902,800 | SH | | DFND | 1 | 0 | 1,902,800 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 2,315 | 101,786 | SH | | DFND | 1 | 0 | 101,786 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 86,606 | 16,671 | SH | Call | DFND | 1 | 0 | 16,671 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122958 | 894 | 172 | SH | Put | DFND | 1 | 0 | 172 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 2,022 | 626,077 | SH | | DFND | 1 | 0 | 626,077 | 0 |
| CELGENE CORP | COM | 151020104 | 2,722 | 19,499 | SH | | DFND | 1 | 0 | 19,499 | 0 |
| CELGENE CORP | COM | 151020954 | 28,534 | 2,044 | SH | Put | DFND | 1 | 0 | 2,044 | 0 |
| CEL-SCI CORP | COM | 150837508 | 20 | 12,888 | SH | | DFND | 1 | 0 | 12,888 | 0 |
| CEL-SCI CORP-W | WAR | 150837177 | 2,684 | 6,316,000 | SH | | DFND | 1 | 0 | 6,316,000 | 0 |
| CELSION CORP | COM | 15117N404 | 766 | 227,156 | SH | | DFND | 1 | 0 | 227,156 | 0 |
| CELSION CORP | COM | 15117N954 | 2,549 | 7,565 | SH | Put | DFND | 1 | 0 | 7,565 | 0 |
| CELSUS THERAPEUTICS-SPON ADR | ADR | 15119A202 | 4,342 | 669,080 | SH | | DFND | 1 | 0 | 669,080 | 0 |
| CEMPRA INC | COM | 15130J109 | 4,689 | 405,946 | SH | | DFND | 1 | 0 | 405,946 | 0 |
| CEMPRA INC | COM | 15130J909 | 140 | 121 | SH | Call | DFND | 1 | 0 | 121 | 0 |
| CERES INC | COM | 156773103 | 1,488 | 1,695,700 | SH | | DFND | 1 | 0 | 1,695,700 | 0 |
| CESCA THERAPEUTICS INC | COM | 157131103 | 900 | 529,298 | SH | | DFND | 1 | 0 | 529,298 | 0 |
| CLEVELAND BIOLABS INC | COM | 185860103 | 1,244 | 1,826,158 | SH | | DFND | 1 | 0 | 1,826,158 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464900 | 13,376 | 1,931 | SH | Call | DFND | 1 | 0 | 1,931 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464950 | 6,927 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| COMPUGEN LTD | ORD | M25722905 | 1,353 | 1,287 | SH | Call | DFND | 1 | 0 | 1,287 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352902 | 174 | 400 | SH | Call | DFND | 1 | 0 | 400 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678107 | 1,214 | 16,590 | SH | | DFND | 1 | 0 | 16,590 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678957 | 4,411 | 603 | SH | Put | DFND | 1 | 0 | 603 | 0 |
| CYTOKINETICS INC | COM | 23282W905 | 628 | 661 | SH | Call | DFND | 1 | 0 | 661 | 0 |
| DEPOMED INC | COM | 249908904 | 103 | 551 | SH | Call | DFND | 1 | 0 | 551 | 0 |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 1,455 | 51,510 | SH | | DFND | 1 | 0 | 51,510 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668403 | 670 | 311,673 | SH | | DFND | 1 | 0 | 311,673 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668903 | 304 | 1,414 | SH | Call | DFND | 1 | 0 | 1,414 | 0 |
| DYAX CORP | COM | 26746E103 | 2,065 | 230,000 | SH | | DFND | 1 | 0 | 230,000 | 0 |
| DYAX CORP | COM | 26746E903 | 146 | 163 | SH | Call | DFND | 1 | 0 | 163 | 0 |
| EDAP TMS SA -ADR | ADR | 268311107 | 66 | 23,200 | SH | | DFND | 1 | 0 | 23,200 | 0 |
| EDAP TMS SA -ADR | ADR | 268311907 | 143 | 500 | SH | Call | DFND | 1 | 0 | 500 | 0 |
| ELI LILLY | COM | 532457908 | 10,118 | 1,719 | SH | Call | DFND | 1 | 0 | 1,719 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M906 | 408 | 102 | SH | Call | DFND | 1 | 0 | 102 | 0 |
| ENDOCYTE INC | COM | 29269A902 | 367 | 154 | SH | Call | DFND | 1 | 0 | 154 | 0 |
| ENDOCYTE INC | COM | 29269A952 | 2,786 | 1,170 | SH | Put | DFND | 1 | 0 | 1,170 | 0 |
| ENTREMED INC | COM | 29382F202 | 1,949 | 1,065,217 | SH | | DFND | 1 | 0 | 1,065,217 | 0 |
| EPIZYME INC | COM | 29428V104 | 3,443 | 151,220 | SH | | DFND | 1 | 0 | 151,220 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 | 765 | 54,000 | SH | | DFND | 1 | 0 | 54,000 | 0 |
| EXACT SCIENCES CORP | COM | 30063P955 | 928 | 655 | SH | Put | DFND | 1 | 0 | 655 | 0 |
| EXELIXIS INC | COM | 30161Q104 | 1,519 | 429,000 | SH | | DFND | 1 | 0 | 429,000 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 754 | 2,129 | SH | Call | DFND | 1 | 0 | 2,129 | 0 |
| EXELIXIS INC | COM | 30161Q954 | 430 | 1,216 | SH | Put | DFND | 1 | 0 | 1,216 | 0 |
| FURIEX PHARMACEUTICALS INC | COM | 36106P101 | 625 | 7,180 | SH | | DFND | 1 | 0 | 7,180 | 0 |
| FURIEX PHARMACEUTICALS INC | COM | 36106P901 | 1,322 | 152 | SH | Call | DFND | 1 | 0 | 152 | 0 |
| GALENA BIOPHARMA INC | COM | 363256108 | 1,770 | 708,089 | SH | | DFND | 1 | 0 | 708,089 | 0 |
| GALENA BIOPHARMA INC | COM | 363256908 | 350 | 1,400 | SH | Call | DFND | 1 | 0 | 1,400 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 2,946 | 11,782 | SH | Put | DFND | 1 | 0 | 11,782 | 0 |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 360 | 31,401 | SH | | DFND | 1 | 0 | 31,401 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 10,988 | 155,073 | SH | | DFND | 1 | 0 | 155,073 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 21,208 | 2,993 | SH | Call | DFND | 1 | 0 | 2,993 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 79,122 | 11,166 | SH | Put | DFND | 1 | 0 | 11,166 | 0 |
| HORIZON PHARMA INC | COM | 44047T959 | 331 | 219 | SH | Put | DFND | 1 | 0 | 219 | 0 |
| IDENIX PHARMACEUTICALS INC | COM | 45166R904 | 785 | 1,302 | SH | Call | DFND | 1 | 0 | 1,302 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K306 | 61 | 15,000 | SH | | DFND | 1 | 0 | 15,000 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K906 | 162 | 398 | SH | Call | DFND | 1 | 0 | 398 | 0 |
| IGNYTA INC | COM | 451731103 | 2,837 | 341,810 | SH | | DFND | 1 | 0 | 341,810 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536955 | 293 | 2,405 | SH | Put | DFND | 1 | 0 | 2,405 | 0 |
| INCYTE CORP | COM | 45337C902 | 5,598 | 1,046 | SH | Call | DFND | 1 | 0 | 1,046 | 0 |
| INSMED INC | COM | 457669907 | 2,479 | 1,302 | SH | Call | DFND | 1 | 0 | 1,302 | 0 |
| INSMED INC | COM | 457669957 | 581 | 305 | SH | Put | DFND | 1 | 0 | 305 | 0 |
| INTERMUNE INC | COM | 45884X903 | 22,171 | 6,624 | SH | Call | DFND | 1 | 0 | 6,624 | 0 |
| INTERMUNE INC | COM | 45884X953 | 15,667 | 4,681 | SH | Put | DFND | 1 | 0 | 4,681 | 0 |
| INTEROIL CORP | COM | 460951106 | 2,743 | 42,361 | SH | | DFND | 1 | 0 | 42,361 | 0 |
| INTEROIL CORP | COM | 460951956 | 5,796 | 895 | SH | Put | DFND | 1 | 0 | 895 | 0 |
| ISHARES | ETF | 464287655 | 10,354 | 890 | SH | Put | DFND | 1 | 0 | 890 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330909 | 6,844 | 1,584 | SH | Call | DFND | 1 | 0 | 1,584 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330959 | 8,979 | 2,078 | SH | Put | DFND | 1 | 0 | 2,078 | 0 |
| ISORAY INC | COM | 46489V104 | 496 | 225,375 | SH | | DFND | 1 | 0 | 225,375 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515101 | 2,863 | 167,999 | SH | | DFND | 1 | 0 | 167,999 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 8,926 | 5,238 | SH | Put | DFND | 1 | 0 | 5,238 | 0 |
| LIGAND PHARMACEUTICALS INC | COM | 53220K904 | 2,825 | 420 | SH | Call | DFND | 1 | 0 | 420 | 0 |
| MACROGENICS INC | COM | 556099109 | 4,190 | 150,553 | SH | | DFND | 1 | 0 | 150,553 | 0 |
| MANNKIND CORP | COM | 56400P901 | 1,019 | 2,536 | SH | Call | DFND | 1 | 0 | 2,536 | 0 |
| MANNKIND CORP | COM | 56400P951 | 8,486 | 21,110 | SH | Put | DFND | 1 | 0 | 21,110 | 0 |
| MEDGENICS INC | WAR | 58436Q112 | 940 | 817,050 | SH | | DFND | 1 | 0 | 817,050 | 0 |
| MEDICINES CO | COM | 584688955 | 523 | 184 | SH | Put | DFND | 1 | 0 | 184 | 0 |
| MEDIVATION INC | COM | 58501N901 | 2,768 | 430 | SH | Call | DFND | 1 | 0 | 430 | 0 |
| MELA SCIENCES INC | COM | 55277R100 | 2,320 | 3,724,475 | SH | | DFND | 1 | 0 | 3,724,475 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 11,445 | 2,016 | SH | Call | DFND | 1 | 0 | 2,016 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 39,705 | 6,994 | SH | Put | DFND | 1 | 0 | 6,994 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 213 | 18,274 | SH | | DFND | 1 | 0 | 18,274 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T900 | 2,014 | 1,729 | SH | Call | DFND | 1 | 0 | 1,729 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T950 | 445 | 382 | SH | Put | DFND | 1 | 0 | 382 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 608 | 50,177 | SH | | DFND | 1 | 0 | 50,177 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268958 | 1,771 | 1,461 | SH | Put | DFND | 1 | 0 | 1,461 | 0 |
| NEOSTEM INC | COM | 640650954 | 538 | 763 | SH | Put | DFND | 1 | 0 | 763 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 2,104 | 1,307 | SH | Call | DFND | 1 | 0 | 1,307 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C959 | 161 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 4,760 | 1,676 | SH | Call | DFND | 1 | 0 | 1,676 | 0 |
| NEWLINK GENETICS CORP | COM | 651511957 | 472 | 166 | SH | Put | DFND | 1 | 0 | 166 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P900 | 399 | 551 | SH | Call | DFND | 1 | 0 | 551 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 628 | 868 | SH | Put | DFND | 1 | 0 | 868 | 0 |
| NOVAVAX INC | COM | 670002104 | 1,139 | 251,500 | SH | | DFND | 1 | 0 | 251,500 | 0 |
| NOVAVAX INC | COM | 670002954 | 3,595 | 7,935 | SH | Put | DFND | 1 | 0 | 7,935 | 0 |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 641 | 60,726 | SH | | DFND | 1 | 0 | 60,726 | 0 |
| OMEROS CORP | COM | 682143102 | 241 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| ONCOGENEX PHARMACEUTICALS INC | COM | 68230A906 | 641 | 545 | SH | Call | DFND | 1 | 0 | 545 | 0 |
| ONCOTHYREON INC | COM | 682324908 | 152 | 511 | SH | Call | DFND | 1 | 0 | 511 | 0 |
| OPHTHOTECH CORP | COM | 683745103 | 570 | 15,944 | SH | | DFND | 1 | 0 | 15,944 | 0 |
| OPHTHOTECH CORP | COM | 683745953 | 1,430 | 400 | SH | Put | DFND | 1 | 0 | 400 | 0 |
| OPKO HEALTH INC | COM | 68375N103 | 7,747 | 831,237 | SH | | DFND | 1 | 0 | 831,237 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 18,735 | 20,102 | SH | Call | DFND | 1 | 0 | 20,102 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 21,648 | 23,227 | SH | Put | DFND | 1 | 0 | 23,227 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164104 | 291 | 44,784 | SH | | DFND | 1 | 0 | 44,784 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164954 | 896 | 1,379 | SH | Put | DFND | 1 | 0 | 1,379 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 3,195 | 357,354 | SH | | DFND | 1 | 0 | 357,354 | 0 |
| OXYGEN BIOTHERAPEUTICS INC | COM | 69207P308 | 11,770 | 2,120,754 | SH | | DFND | 1 | 0 | 2,120,754 | 0 |
| OXYGEN BIOTHERAPEUTICS INC | COM | 69207P908 | 152 | 274 | SH | Call | DFND | 1 | 0 | 274 | 0 |
| PACIFIC ETHANOL INC | COM | 69423U955 | 797 | 512 | SH | Put | DFND | 1 | 0 | 512 | 0 |
| PEREGRINE PHARMACEUTICALS INC | COM | 713661304 | 6,017 | 238,409 | SH | | DFND | 1 | 0 | 238,409 | 0 |
| PFIZER INC | COM | 717081903 | 13,815 | 4,301 | SH | Call | DFND | 1 | 0 | 4,301 | 0 |
| PFIZER INC | COM | 717081953 | 2,088 | 650 | SH | Put | DFND | 1 | 0 | 650 | 0 |
| PHARMACYCLICS INC | COM | 716933906 | 15,033 | 1,500 | SH | Call | DFND | 1 | 0 | 1,500 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 15,324 | 1,529 | SH | Put | DFND | 1 | 0 | 1,529 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R102 | 938 | 253,383 | SH | | DFND | 1 | 0 | 253,383 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 3,553 | 9,603 | SH | Put | DFND | 1 | 0 | 9,603 | 0 |
| PRANA BIOTECHNOLOGY LTD | ADR | 739727105 | 48 | 17,300 | SH | | DFND | 1 | 0 | 17,300 | 0 |
| PRANA BIOTECHNOLOGY LTD | ADR | 739727905 | 838 | 2,994 | SH | Call | DFND | 1 | 0 | 2,994 | 0 |
| PRANA BIOTECHNOLOGY LTD | ADR | 739727955 | 62 | 222 | SH | Put | DFND | 1 | 0 | 222 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187106 | 2,118 | 517,794 | SH | | DFND | 1 | 0 | 517,794 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187906 | 324 | 794 | SH | Call | DFND | 1 | 0 | 794 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187956 | 122 | 298 | SH | Put | DFND | 1 | 0 | 298 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800908 | 862 | 225 | SH | Call | DFND | 1 | 0 | 225 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800958 | 479 | 125 | SH | Put | DFND | 1 | 0 | 125 | 0 |
| PSIVIDA CORP | COM | 74440J901 | 41 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| PSIVIDA CORP | COM | 74440J951 | 262 | 640 | SH | Put | DFND | 1 | 0 | 640 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V907 | 5,332 | 512 | SH | Call | DFND | 1 | 0 | 512 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V957 | 2,822 | 271 | SH | Put | DFND | 1 | 0 | 271 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 1,647 | 227,793 | SH | | DFND | 1 | 0 | 227,793 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 5,162 | 17,191 | SH | | DFND | 1 | 0 | 17,191 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F907 | 36,514 | 1,216 | SH | Call | DFND | 1 | 0 | 1,216 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F957 | 39,006 | 1,299 | SH | Put | DFND | 1 | 0 | 1,299 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 5,980 | 3,371 | SH | Put | DFND | 1 | 0 | 3,371 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 7,155 | 5,652 | SH | Put | DFND | 1 | 0 | 5,652 | 0 |
| SALIX PHARMACEUTICALS LTD | COM | 795435106 | 225 | 2,170 | SH | | DFND | 1 | 0 | 2,170 | 0 |
| SALIX PHARMACEUTICALS LTD | COM | 795435956 | 1,533 | 148 | SH | Put | DFND | 1 | 0 | 148 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 3,205 | 177,265 | SH | | DFND | 1 | 0 | 177,265 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677906 | 18,098 | 10,010 | SH | Call | DFND | 1 | 0 | 10,010 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 8,461 | 352,100 | SH | | DFND | 1 | 0 | 352,100 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 843 | 351 | SH | Call | DFND | 1 | 0 | 351 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 9,756 | 4,060 | SH | Put | DFND | 1 | 0 | 4,060 | 0 |
| SEATTLE GENETICS INC | COM | 812578902 | 16,907 | 3,711 | SH | Call | DFND | 1 | 0 | 3,711 | 0 |
| SEATTLE GENETICS INC | COM | 812578952 | 15,932 | 3,497 | SH | Put | DFND | 1 | 0 | 3,497 | 0 |
| SEMLER SCIENTIFIC INC | COM | 81684M104 | 1,664 | 318,198 | SH | | DFND | 1 | 0 | 318,198 | 0 |
| SPDR S&P 500 ETF TR | UNIT | 78462F103 | 25,026 | 1,338 | SH | Put | DFND | 1 | 0 | 1,338 | 0 |
| SPDR SERIES TRUST | TR | 78464A870 | 6,233 | 43,745 | SH | | DFND | 1 | 0 | 43,745 | 0 |
| SPDR SERIES TRUST | TR | 78464A950 | 28,581 | 2,006 | SH | Put | DFND | 1 | 0 | 2,006 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328901 | 2,075 | 3,139 | SH | Call | DFND | 1 | 0 | 3,139 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328951 | 541 | 818 | SH | Put | DFND | 1 | 0 | 818 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A103 | 1,123 | 13,538 | SH | | DFND | 1 | 0 | 13,538 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A953 | 11,043 | 1,331 | SH | Put | DFND | 1 | 0 | 1,331 | 0 |
| SYNERGY PHARMACEUTICALS | WAR | 871639308 | 718 | 377,908 | SH | | DFND | 1 | 0 | 377,908 | 0 |
| TEKMIRA PHARMACEUTICALS CORP | COM | 87911B909 | 967 | 450 | SH | Call | DFND | 1 | 0 | 450 | 0 |
| TESARO INC | COM | 881569107 | 2,904 | 98,500 | SH | | DFND | 1 | 0 | 98,500 | 0 |
| TESARO INC | COM | 881569907 | 413 | 140 | SH | Call | DFND | 1 | 0 | 140 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624209 | 19,273 | 364,741 | SH | | DFND | 1 | 0 | 364,741 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 80,275 | 15,192 | SH | Call | DFND | 1 | 0 | 15,192 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 123,820 | 23,433 | SH | Put | DFND | 1 | 0 | 23,433 | 0 |
| THERAVANCE INC | COM | 88338T104 | 1,068 | 34,531 | SH | | DFND | 1 | 0 | 34,531 | 0 |
| THERAVANCE INC | COM | 88338T954 | 1,661 | 537 | SH | Put | DFND | 1 | 0 | 537 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 4,645 | 38,630 | SH | | DFND | 1 | 0 | 38,630 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556902 | 13,226 | 1,100 | SH | Call | DFND | 1 | 0 | 1,100 | 0 |
| TONIX PHARMACEUTICALS HOLDIN | COM | 890260201 | 2,863 | 275,000 | SH | | DFND | 1 | 0 | 275,000 | 0 |
| TROVAGENE INC | COM | 897238309 | 115 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| UNIQURE B.V. | SHS | N90064101 | 5,505 | 354,000 | SH | | DFND | 1 | 0 | 354,000 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 4,796 | 510 | SH | Call | DFND | 1 | 0 | 510 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C952 | 2,040 | 217 | SH | Put | DFND | 1 | 0 | 217 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 169,728 | 24,000 | SH | Call | DFND | 1 | 0 | 24,000 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 41,909 | 5,926 | SH | Put | DFND | 1 | 0 | 5,926 | 0 |
| VIVUS INC | COM | 928551100 | 131 | 22,032 | SH | | DFND | 1 | 0 | 22,032 | 0 |
| VIVUS INC | COM | 928551950 | 112 | 189 | SH | Put | DFND | 1 | 0 | 189 | 0 |
| XOMA CORP | COM | 98419J107 | 858 | 164,728 | SH | | DFND | 1 | 0 | 164,728 | 0 |
| XOMA CORP | COM | 98419J907 | 559 | 1,073 | SH | Call | DFND | 1 | 0 | 1,073 | 0 |
| XOMA CORP | COM | 98419J957 | 564 | 1,082 | SH | Put | DFND | 1 | 0 | 1,082 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P101 | 506 | 110,573 | SH | | DFND | 1 | 0 | 110,573 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P901 | 316 | 690 | SH | Call | DFND | 1 | 0 | 690 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P951 | 667 | 1,457 | SH | Put | DFND | 1 | 0 | 1,457 | 0 |
