| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y909 | 72,813 | 12,901 | SH | Call | DFND | 1 | 0 | 12,901 | 0 |
| ABBVIE INC | COM | 00287Y959 | 15,307 | 2,712 | SH | Put | DFND | 1 | 0 | 2,712 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 13,311 | 589,264 | SH | | DFND | 1 | 0 | 589,264 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 62,064 | 27,474 | SH | Call | DFND | 1 | 0 | 27,474 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225958 | 2,169 | 960 | SH | Put | DFND | 1 | 0 | 960 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T100 | 1,055 | 102,900 | SH | | DFND | 1 | 0 | 102,900 | 0 |
| ACELRX PHARMACEUTICALS INC | COM | 00444T950 | 2,613 | 2,549 | SH | Put | DFND | 1 | 0 | 2,549 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 12,102 | 15,987 | SH | Call | DFND | 1 | 0 | 15,987 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 1,269 | 1,677 | SH | Put | DFND | 1 | 0 | 1,677 | 0 |
| ACTAVIS PLC | SHS | G0083B108 | 7,445 | 33,376 | SH | | DFND | 1 | 0 | 33,376 | 0 |
| ACTAVIS PLC | SHS | G0083B908 | 17,286 | 775 | SH | Call | DFND | 1 | 0 | 775 | 0 |
| ACTAVIS PLC | SHS | G0083B958 | 16,729 | 750 | SH | Put | DFND | 1 | 0 | 750 | 0 |
| ADVAXIS INC | COM | 007624208 | 60 | 19,000 | SH | | DFND | 1 | 0 | 19,000 | 0 |
| ADVAXIS INC | COM | 007624958 | 315 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| ADVAXIS INC-CW18 | *W | 007624117 | 46 | 45,354 | SH | | DFND | 1 | 0 | 45,354 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E902 | 8,664 | 2,700 | SH | Call | DFND | 1 | 0 | 2,700 | 0 |
| AGENUS INC | COM | 00847G955 | 79 | 245 | SH | Put | DFND | 1 | 0 | 245 | 0 |
| ALCOBRA LTD | SHS | M2239P959 | 344 | 199 | SH | Put | DFND | 1 | 0 | 199 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384909 | 932 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALIMERA SCIENCES INC | COM | 016259103 | 598 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| ALIMERA SCIENCES INC | COM | 016259903 | 533 | 891 | SH | Call | DFND | 1 | 0 | 891 | 0 |
| ALIMERA SCIENCES INC | COM | 016259953 | 293 | 490 | SH | Put | DFND | 1 | 0 | 490 | 0 |
| ALKERMES PLC | SHS | G01767905 | 7,051 | 1,401 | SH | Call | DFND | 1 | 0 | 1,401 | 0 |
| ALLERGAN INC | COM | 018490902 | 16,888 | 998 | SH | Call | DFND | 1 | 0 | 998 | 0 |
| ALLERGAN INC | COM | 018490952 | 3,097 | 183 | SH | Put | DFND | 1 | 0 | 183 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 758 | 12,000 | SH | | DFND | 1 | 0 | 12,000 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 600 | 95 | SH | Call | DFND | 1 | 0 | 95 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q957 | 6,797 | 1,076 | SH | Put | DFND | 1 | 0 | 1,076 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111206 | 1,144 | 650,000 | SH | | DFND | 1 | 0 | 650,000 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111906 | 950 | 5,396 | SH | Call | DFND | 1 | 0 | 5,396 | 0 |
| AMGEN INC | COM | 031162100 | 5,883 | 49,703 | SH | | DFND | 1 | 0 | 49,703 | 0 |
| AMGEN INC | COM | 031162950 | 13,175 | 1,113 | SH | Put | DFND | 1 | 0 | 1,113 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 334 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T109 | 397 | 47,500 | SH | | DFND | 1 | 0 | 47,500 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T959 | 1,495 | 1,791 | SH | Put | DFND | 1 | 0 | 1,791 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U201 | 1,519 | 448,000 | SH | | DFND | 1 | 0 | 448,000 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U901 | 138 | 406 | SH | Call | DFND | 1 | 0 | 406 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V109 | 23 | 10,203 | SH | | DFND | 1 | 0 | 10,203 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V959 | 340 | 1,510 | SH | Put | DFND | 1 | 0 | 1,510 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047102 | 690 | 117,822 | SH | | DFND | 1 | 0 | 117,822 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 179 | 306 | SH | Call | DFND | 1 | 0 | 306 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 2,404 | 4,102 | SH | Put | DFND | 1 | 0 | 4,102 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A100 | 808 | 126,884 | SH | | DFND | 1 | 0 | 126,884 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 165 | 259 | SH | Call | DFND | 1 | 0 | 259 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 1,208 | 1,896 | SH | Put | DFND | 1 | 0 | 1,896 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797209 | 2,466 | 172,353 | SH | | DFND | 1 | 0 | 172,353 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797909 | 1,013 | 708 | SH | Call | DFND | 1 | 0 | 708 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797959 | 4,277 | 2,989 | SH | Put | DFND | 1 | 0 | 2,989 | 0 |
| ASTRAZENECA PLC | ADR | 046353108 | 4,182 | 56,275 | SH | | DFND | 1 | 0 | 56,275 | 0 |
| ASTRAZENECA PLC | ADR | 046353908 | 8,561 | 1,152 | SH | Call | DFND | 1 | 0 | 1,152 | 0 |
| ASTRAZENECA PLC | ADR | 046353958 | 7,372 | 992 | SH | Put | DFND | 1 | 0 | 992 | 0 |
| ATHERSYS INC | COM | 04744L906 | 30 | 170 | SH | Call | DFND | 1 | 0 | 170 | 0 |
| ATHERSYS INC | COM | 04744L956 | 207 | 1,159 | SH | Put | DFND | 1 | 0 | 1,159 | 0 |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 1,114 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D907 | 7,701 | 3,839 | SH | Call | DFND | 1 | 0 | 3,839 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P401 | 2,448 | 434,000 | SH | | DFND | 1 | 0 | 434,000 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P901 | 1,055 | 1,870 | SH | Call | DFND | 1 | 0 | 1,870 | 0 |
| BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 994 | 77,987 | SH | | DFND | 1 | 0 | 77,987 | 0 |
| BIODEL INC | COM | 09064M204 | 520 | 240,600 | SH | | DFND | 1 | 0 | 240,600 | 0 |
| BIODEL INC | COM | 09064M954 | 39 | 182 | SH | Put | DFND | 1 | 0 | 182 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 109,980 | 3,488 | SH | Call | DFND | 1 | 0 | 3,488 | 0 |
| BIOGEN IDEC INC | COM | 09062X953 | 15,040 | 477 | SH | Put | DFND | 1 | 0 | 477 | 0 |
| BIOLINERX LTD | ADR | 09071M106 | 4,204 | 2,021,347 | SH | | DFND | 1 | 0 | 2,021,347 | 0 |
| BLUEBIRD BIO INC | COM | 09609G900 | 2,661 | 690 | SH | Call | DFND | 1 | 0 | 690 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 1,453 | 29,949 | SH | | DFND | 1 | 0 | 29,949 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122908 | 6,854 | 1,413 | SH | Call | DFND | 1 | 0 | 1,413 | 0 |
| BRISTOL-MYERS SQUIBB CO | COM | 110122958 | 9,188 | 1,894 | SH | Put | DFND | 1 | 0 | 1,894 | 0 |
| CBS CORP-CLASS B NON VOTING | CL B | 124857202 | 2,989 | 48,100 | SH | | DFND | 1 | 0 | 48,100 | 0 |
| CBS OUTDOOR AMERICAS INC | COM | 14987J106 | 1,148 | 35,142 | SH | | DFND | 1 | 0 | 35,142 | 0 |
| CBS OUTDOOR AMERICAS INC | COM | 14987J956 | 9,321 | 1,500 | SH | Put | DFND | 1 | 0 | 1,500 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 1,011 | 341,624 | SH | | DFND | 1 | 0 | 341,624 | 0 |
| CELGENE CORP | COM | 151020904 | 28,066 | 3,268 | SH | Call | DFND | 1 | 0 | 3,268 | 0 |
| CELGENE CORP | COM | 151020954 | 26,846 | 3,126 | SH | Put | DFND | 1 | 0 | 3,126 | 0 |
| CEL-SCI CORP | COM | 150837508 | 16 | 12,888 | SH | | DFND | 1 | 0 | 12,888 | 0 |
| CEL-SCI CORP- CW18 | *W | 150837177 | 1,165 | 4,849,000 | SH | | DFND | 1 | 0 | 4,849,000 | 0 |
| CELSION CORP | COM | 15117N404 | 521 | 150,047 | SH | | DFND | 1 | 0 | 150,047 | 0 |
| CELSION CORP | COM | 15117N954 | 2,781 | 8,014 | SH | Put | DFND | 1 | 0 | 8,014 | 0 |
| CELSUS THERAPEUTICS-SPON ADR | ADR | 15119A202 | 4,510 | 819,911 | SH | | DFND | 1 | 0 | 819,911 | 0 |
| CEMPRA INC | COM | 15130J109 | 1,599 | 149,000 | SH | | DFND | 1 | 0 | 149,000 | 0 |
| CEMPRA INC | COM | 15130J909 | 268 | 250 | SH | Call | DFND | 1 | 0 | 250 | 0 |
| CERES INC | COM | 156773103 | 989 | 1,484,866 | SH | | DFND | 1 | 0 | 1,484,866 | 0 |
| CESCA THERAPEUTICS INC | COM | 157131103 | 4,612 | 3,317,805 | SH | | DFND | 1 | 0 | 3,317,805 | 0 |
| CLEVELAND BIOLABS INC | COM | 185860103 | 147 | 306,165 | SH | | DFND | 1 | 0 | 306,165 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 828 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464900 | 8,274 | 1,998 | SH | Call | DFND | 1 | 0 | 1,998 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464950 | 853 | 206 | SH | Put | DFND | 1 | 0 | 206 | 0 |
| COMPUGEN LTD | ORD | M25722905 | 135 | 150 | SH | Call | DFND | 1 | 0 | 150 | 0 |
| CORIUM INTERNATIONAL INC | COM | 21887L107 | 1,031 | 132,722 | SH | | DFND | 1 | 0 | 132,722 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678107 | 1,263 | 18,086 | SH | | DFND | 1 | 0 | 18,086 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678957 | 421,015 | 603 | SH | Put | DFND | 1 | 0 | 603 | 0 |
| CYTORI THERAPEUTICS INC | COM | 23283K105 | 4,292 | 1,795,963 | SH | | DFND | 1 | 0 | 1,795,963 | 0 |
| DEPOMED INC | COM | 249908904 | 766 | 551 | SH | Call | DFND | 1 | 0 | 551 | 0 |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 3,453 | 152,994 | SH | | DFND | 1 | 0 | 152,994 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668403 | 562 | 315,661 | SH | | DFND | 1 | 0 | 315,661 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668903 | 246 | 1,384 | SH | Call | DFND | 1 | 0 | 1,384 | 0 |
| EDAP TMS SA | ADR | 268311907 | 372 | 746 | SH | Call | DFND | 1 | 0 | 746 | 0 |
| EDAP TMS SA | ADR | 268311957 | 162 | 326 | SH | Put | DFND | 1 | 0 | 326 | 0 |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 1,898 | 143,974 | SH | | DFND | 1 | 0 | 143,974 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M906 | 440 | 102 | SH | Call | DFND | 1 | 0 | 102 | 0 |
| ENDOCYTE INC | COM | 29269A902 | 764 | 1,160 | SH | Call | DFND | 1 | 0 | 1,160 | 0 |
| ENDOCYTE INC | COM | 29269A952 | 569 | 863 | SH | Put | DFND | 1 | 0 | 863 | 0 |
| EPIZYME INC | COM | 29428V104 | 1,518 | 48,790 | SH | | DFND | 1 | 0 | 48,790 | 0 |
| EPIZYME INC | COM | 29428V904 | 479 | 154 | SH | Call | DFND | 1 | 0 | 154 | 0 |
| EXELIXIS INC | COM | 30161Q104 | 549 | 162,000 | SH | | DFND | 1 | 0 | 162,000 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 1,138 | 3,356 | SH | Call | DFND | 1 | 0 | 3,356 | 0 |
| EXELIXIS INC | COM | 30161Q954 | 890 | 2,625 | SH | Put | DFND | 1 | 0 | 2,625 | 0 |
| FURIEX PHARMACEUTICALS INC | COM | 36106P901 | 2,049 | 193 | SH | Call | DFND | 1 | 0 | 193 | 0 |
| GALENA BIOPHARMA INC | COM | 363256108 | 812 | 265,350 | SH | | DFND | 1 | 0 | 265,350 | 0 |
| GALENA BIOPHARMA INC | COM | 363256908 | 448 | 1,466 | SH | Call | DFND | 1 | 0 | 1,466 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 2,190 | 7,156 | SH | Put | DFND | 1 | 0 | 7,156 | 0 |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 306 | 31,401 | SH | | DFND | 1 | 0 | 31,401 | 0 |
| GERON CORP | COM | 374163903 | 1,172 | 3,651 | SH | Call | DFND | 1 | 0 | 3,651 | 0 |
| GERON CORP | COM | 374163953 | 34 | 107 | SH | Put | DFND | 1 | 0 | 107 | 0 |
| GEVO INC | COM | 374396109 | 478 | 555,456 | SH | | DFND | 1 | 0 | 555,456 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 16,623 | 3,006 | SH | Call | DFND | 1 | 0 | 3,006 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 1,393 | 168 | SH | Put | DFND | 1 | 0 | 168 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 78,665 | 9,488 | SH | Put | DFND | 1 | 0 | 9,488 | 0 |
| GW PHARMACEUTICALS PLC | ADS | 36197T903 | 5,204 | 485 | SH | Call | DFND | 1 | 0 | 485 | 0 |
| GW PHARMACEUTICALS PLC | ADS | 36197T953 | 2,017 | 188 | SH | Put | DFND | 1 | 0 | 188 | 0 |
| HARVARD APPARATUS REGENERATION | COM | 41690A106 | 290 | 27,730 | SH | | DFND | 1 | 0 | 27,730 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 | 1,667 | 135,281 | SH | | DFND | 1 | 0 | 135,281 | 0 |
| HORIZON PHARMA INC | COM | 44047T959 | 346 | 219 | SH | Put | DFND | 1 | 0 | 219 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K306 | 1,788 | 616,600 | SH | | DFND | 1 | 0 | 616,600 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K906 | 156 | 538 | SH | Call | DFND | 1 | 0 | 538 | 0 |
| IGNYTA INC | COM | 451731103 | 445 | 49,000 | SH | | DFND | 1 | 0 | 49,000 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536955 | 22 | 194 | SH | Put | DFND | 1 | 0 | 194 | 0 |
| INCYTE CORP | COM | 45337C902 | 2,433 | 431 | SH | Call | DFND | 1 | 0 | 431 | 0 |
| INSMED INC | COM | 457669907 | 873 | 438 | SH | Call | DFND | 1 | 0 | 438 | 0 |
| INTELLIPHARMACEUTICS INTERNAINC COM | COM | 458173101 | 1,196 | 314,000 | SH | | DFND | 1 | 0 | 314,000 | 0 |
| INTERCEPT PHARMACEUTICALS INC | COM | 45845P908 | 1,609 | 68 | SH | Call | DFND | 1 | 0 | 68 | 0 |
| INTERMUNE INC | COM | 45884X903 | 5,453 | 1,235 | SH | Call | DFND | 1 | 0 | 1,235 | 0 |
| INTERMUNE INC | COM | 45884X953 | 5,819 | 1,318 | SH | Put | DFND | 1 | 0 | 1,318 | 0 |
| INTEROIL CORP | COM | 460951106 | 8,427 | 131,794 | SH | | DFND | 1 | 0 | 131,794 | 0 |
| INTEROIL CORP | COM | 460951956 | 21,529 | 3,367 | SH | Put | DFND | 1 | 0 | 3,367 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 49,496 | 4,166 | SH | Put | DFND | 1 | 0 | 4,166 | 0 |
| KYTHERA BIOPHARMACEUTICALS INC | COM | 501570905 | 1,151 | 300 | SH | Call | DFND | 1 | 0 | 300 | 0 |
| LIPOCINE INC | COM | 53630X104 | 2,542 | 416,700 | SH | | DFND | 1 | 0 | 416,700 | 0 |
| MACROGENICS INC | COM | 556099109 | 3,256 | 149,839 | SH | | DFND | 1 | 0 | 149,839 | 0 |
| MANNKIND CORP | COM | 56400P901 | 25,293 | 23,015 | SH | Call | DFND | 1 | 0 | 23,015 | 0 |
| MANNKIND CORP | COM | 56400P951 | 22,172 | 20,175 | SH | Put | DFND | 1 | 0 | 20,175 | 0 |
| MEDGENICS INC - CW18 | *W | 58436Q112 | 1,113 | 830,312 | SH | | DFND | 1 | 0 | 830,312 | 0 |
| MEDICINES CO | COM | 584688105 | 231 | 7,948 | SH | | DFND | 1 | 0 | 7,948 | 0 |
| MEDICINES CO | COM | 584688955 | 535 | 184 | SH | Put | DFND | 1 | 0 | 184 | 0 |
| MEI PHARMA INC | COM | 55279B202 | 1,712 | 270,000 | SH | | DFND | 1 | 0 | 270,000 | 0 |
| MELA SCIENCES INC | COM | 55277R100 | 1,056 | 3,288,019 | SH | | DFND | 1 | 0 | 3,288,019 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 1,736 | 300 | SH | Put | DFND | 1 | 0 | 300 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 648 | 50,514 | SH | | DFND | 1 | 0 | 50,514 | 0 |
| NEOSTEM INC | COM | 640650404 | 542 | 83,167 | SH | | DFND | 1 | 0 | 83,167 | 0 |
| NEOSTEM INC | COM | 640650954 | 658 | 1,009 | SH | Put | DFND | 1 | 0 | 1,009 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 1,969 | 1,327 | SH | Call | DFND | 1 | 0 | 1,327 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C959 | 148 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| NEUROMETRIX INC | COM | 641255302 | 226 | 116,400 | SH | | DFND | 1 | 0 | 116,400 | 0 |
| NEWLINK GENETICS CORP | COM | 651511107 | 1,224 | 46,098 | SH | | DFND | 1 | 0 | 46,098 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 2,620 | 987 | SH | Call | DFND | 1 | 0 | 987 | 0 |
| NEWLINK GENETICS CORP | COM | 651511957 | 435 | 164 | SH | Put | DFND | 1 | 0 | 164 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P900 | 254 | 378 | SH | Call | DFND | 1 | 0 | 378 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 1,235 | 1,841 | SH | Put | DFND | 1 | 0 | 1,841 | 0 |
| NOVAVAX INC | COM | 670002104 | 1,933 | 418,378 | SH | | DFND | 1 | 0 | 418,378 | 0 |
| NOVAVAX INC | COM | 670002954 | 2,516 | 5,445 | SH | Put | DFND | 1 | 0 | 5,445 | 0 |
| NOVO NORDISK A/S | ADR | 670100955 | 1,958 | 424 | SH | Put | DFND | 1 | 0 | 424 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 993 | 30,058 | SH | | DFND | 1 | 0 | 30,058 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P953 | 4,346 | 1,315 | SH | Put | DFND | 1 | 0 | 1,315 | 0 |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 1,156 | 151,358 | SH | | DFND | 1 | 0 | 151,358 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H200 | 940 | 98,800 | SH | | DFND | 1 | 0 | 98,800 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H900 | 745 | 783 | SH | Call | DFND | 1 | 0 | 783 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H950 | 487 | 512 | SH | Put | DFND | 1 | 0 | 512 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A106 | 3,441 | 922,562 | SH | | DFND | 1 | 0 | 922,562 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A906 | 164 | 439 | SH | Call | DFND | 1 | 0 | 439 | 0 |
| ONCOTHYREON INC | COM | 682324908 | 76 | 236 | SH | Call | DFND | 1 | 0 | 236 | 0 |
| OPKO HEALTH INC | COM | 68375N103 | 10,555 | 1,193,955 | SH | | DFND | 1 | 0 | 1,193,955 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 2,044 | 22,661 | SH | Call | DFND | 1 | 0 | 22,661 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 23,215 | 26,261 | SH | Put | DFND | 1 | 0 | 26,261 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164104 | 309 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164954 | 865 | 1,400 | SH | Put | DFND | 1 | 0 | 1,400 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 1,657 | 180,690 | SH | | DFND | 1 | 0 | 180,690 | 0 |
| OXIGENE INC | COM | 691828404 | 2,879 | 1,111,798 | SH | | DFND | 1 | 0 | 1,111,798 | 0 |
| OXIGENE INC | COM | 691828904 | 71 | 275 | SH | Call | DFND | 1 | 0 | 275 | 0 |
| OXYGEN BIOTHERAPEUTICS INC | COM | 69207P308 | 11,110 | 2,722,929 | SH | | DFND | 1 | 0 | 2,722,929 | 0 |
| OXYGEN BIOTHERAPEUTICS INC | COM | 69207P908 | 244 | 599 | SH | Call | DFND | 1 | 0 | 599 | 0 |
| PACIFIC ETHANOL INC | COM | 69423U305 | 604 | 39,500 | SH | | DFND | 1 | 0 | 39,500 | 0 |
| PACIFIC ETHANOL INC | COM | 69423U955 | 783 | 512 | SH | Put | DFND | 1 | 0 | 512 | 0 |
| PEREGRINE PHARMACEUTICAL | COM | 713661304 | 7,028 | 291,600 | SH | | DFND | 1 | 0 | 291,600 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 260 | 29 | SH | Put | DFND | 1 | 0 | 29 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R102 | 125 | 39,900 | SH | | DFND | 1 | 0 | 39,900 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 1,039 | 3,321 | SH | Put | DFND | 1 | 0 | 3,321 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187106 | 1,574 | 365,186 | SH | | DFND | 1 | 0 | 365,186 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187906 | 211 | 490 | SH | Call | DFND | 1 | 0 | 490 | 0 |
| PROGENICS PHARMACEUTICALS | COM | 743187956 | 50 | 117 | SH | Put | DFND | 1 | 0 | 117 | 0 |
| PROTHENA CORP PLC | SHS | G72800108 | 221 | 9,800 | SH | | DFND | 1 | 0 | 9,800 | 0 |
| PROTHENA CORP PLC | SHS | G72800958 | 226 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| PSIVIDA CORP | COM | 74440J901 | 152 | 350 | SH | Call | DFND | 1 | 0 | 350 | 0 |
| PSIVIDA CORP | COM | 74440J951 | 386 | 890 | SH | Put | DFND | 1 | 0 | 890 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V907 | 495 | 75 | SH | Call | DFND | 1 | 0 | 75 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V957 | 290 | 44 | SH | Put | DFND | 1 | 0 | 44 | 0 |
| QUINPARIO ACQUISITION CORP | COM | 74874R108 | 4,844 | 461,756 | SH | | DFND | 1 | 0 | 461,756 | 0 |
| QUINPARIO ACQUISITION - CW18 | *W | 74874R116 | 82 | 60,400 | SH | | DFND | 1 | 0 | 60,400 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 1,497 | 186,940 | SH | | DFND | 1 | 0 | 186,940 | 0 |
| REGADO BIOSCIENCE INC | COM | 75874Q107 | 889 | 131,000 | SH | | DFND | 1 | 0 | 131,000 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 13,609 | 48,177 | SH | | DFND | 1 | 0 | 48,177 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F907 | 32,936 | 1,166 | SH | Call | DFND | 1 | 0 | 1,166 | 0 |
| REGENERON PHARMACEUTICALS | COM | 75886F957 | 54,037 | 1,913 | SH | Put | DFND | 1 | 0 | 1,913 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H209 | 1,141 | 65,978 | SH | | DFND | 1 | 0 | 65,978 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 5,969 | 3,450 | SH | Put | DFND | 1 | 0 | 3,450 | 0 |
| RETROPHIN INC | COM | 761299906 | 1,961 | 1,670 | SH | Call | DFND | 1 | 0 | 1,670 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 | 2,285 | 67,200 | SH | | DFND | 1 | 0 | 67,200 | 0 |
| RICEBRAN TECHNOLOGIES | COM | 762831204 | 2,857 | 541,044 | SH | | DFND | 1 | 0 | 541,044 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 6,476 | 5,401 | SH | Put | DFND | 1 | 0 | 5,401 | 0 |
| SALIX PHARMACEUTICALS | COM | 795435106 | 6,094 | 49,403 | SH | | DFND | 1 | 0 | 49,403 | 0 |
| SALIX PHARMACEUTICALS | COM | 795435906 | 1,690 | 137 | SH | Call | DFND | 1 | 0 | 137 | 0 |
| SALIX PHARMACEUTICALS | COM | 795435956 | 2,331 | 189 | SH | Put | DFND | 1 | 0 | 189 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 6,769 | 443,286 | SH | | DFND | 1 | 0 | 443,286 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677906 | 15,288 | 10,012 | SH | Call | DFND | 1 | 0 | 10,012 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,777 | 126,772 | SH | | DFND | 1 | 0 | 126,772 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 4,880 | 1,638 | SH | Call | DFND | 1 | 0 | 1,638 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 5,043 | 1,693 | SH | Put | DFND | 1 | 0 | 1,693 | 0 |
| SEATTLE GENETICS INC | COM | 812578902 | 807 | 211 | SH | Call | DFND | 1 | 0 | 211 | 0 |
| SEATTLE GENETICS INC | COM | 812578952 | 673 | 176 | SH | Put | DFND | 1 | 0 | 176 | 0 |
| SEMLER SCIENTIFIC INC | COM | 81684M104 | 1,380 | 334,038 | SH | | DFND | 1 | 0 | 334,038 | 0 |
| SPDR S&P BIOTECH | ETF | 78464A950 | 1,632 | 106 | SH | Put | DFND | 1 | 0 | 106 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328901 | 2,480 | 3,803 | SH | Call | DFND | 1 | 0 | 3,803 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328951 | 752 | 1,153 | SH | Put | DFND | 1 | 0 | 1,153 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A953 | 13,949 | 1,331 | SH | Put | DFND | 1 | 0 | 1,331 | 0 |
| SYNERGY PHARMACEUTICALS - CW16 | *W | 871639118 | 515 | 389,982 | SH | | DFND | 1 | 0 | 389,982 | 0 |
| TESARO INC | COM | 881569907 | 3,985 | 1,281 | SH | Call | DFND | 1 | 0 | 1,281 | 0 |
| TESARO INC | COM | 881569957 | 1,556 | 500 | SH | Put | DFND | 1 | 0 | 500 | 0 |
| TESLA MOTORS INC | COM | 88160R101 | 5,175 | 21,557 | SH | | DFND | 1 | 0 | 21,557 | 0 |
| TESLA MOTORS INC | COM | 88160R951 | 23,886 | 995 | SH | Put | DFND | 1 | 0 | 995 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624209 | 53,117 | 1,013,302 | SH | | DFND | 1 | 0 | 1,013,302 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 36,013 | 6,870 | SH | Call | DFND | 1 | 0 | 6,870 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 81,639 | 15,574 | SH | Put | DFND | 1 | 0 | 15,574 | 0 |
| TONIX PHARMACEUTICALS HOLDING CORP | COM | 890260201 | 2,696 | 187,894 | SH | | DFND | 1 | 0 | 187,894 | 0 |
| TONIX PHARMACEUTICALS HOLDING CORP | COM | 890260951 | 1,435 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| TRI POINTE HOMES INC | COM | 87265h109 | 290 | 18,438 | SH | | DFND | 1 | 0 | 18,438 | 0 |
| TRI POINTE HOMES INC | COM | 87265H959 | 12,397 | 7,886 | SH | Put | DFND | 1 | 0 | 7,886 | 0 |
| TROVAGENE INC | COM | 897238309 | 70 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| UNIQURE B.V. | SHS | N90064101 | 3,059 | 225,081 | SH | | DFND | 1 | 0 | 225,081 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 3,442 | 389 | SH | Call | DFND | 1 | 0 | 389 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C952 | 1,053 | 119 | SH | Put | DFND | 1 | 0 | 119 | 0 |
| UNITEDHEALTH GROUP INC | COM | 91324P902 | 3,679 | 450 | SH | Call | DFND | 1 | 0 | 450 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 2,103 | 130,000 | SH | | DFND | 1 | 0 | 130,000 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659908 | 2,751 | 1,700 | SH | Call | DFND | 1 | 0 | 1,700 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 282,487 | 29,836 | SH | Call | DFND | 1 | 0 | 29,836 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 94,358 | 9,966 | SH | Put | DFND | 1 | 0 | 9,966 | 0 |
| VIVUS INC | COM | 928551900 | 795 | 1,495 | SH | Call | DFND | 1 | 0 | 1,495 | 0 |
| WELLPOINT INC | COM | 94973V907 | 5,940 | 552 | SH | Call | DFND | 1 | 0 | 552 | 0 |
| WEYERHAEUSER CO | COM | 962166104 | 64,558 | 1,950,977 | SH | | DFND | 1 | 0 | 1,950,977 | 0 |
| WEYERHAEUSER CO | COM | 962166954 | 44,672 | 13,500 | SH | Put | DFND | 1 | 0 | 13,500 | 0 |
| XENCOR INC | COM | 98401F105 | 2,437 | 209,686 | SH | | DFND | 1 | 0 | 209,686 | 0 |
| XOMA CORP | COM | 98419J107 | 1,297 | 282,594 | SH | | DFND | 1 | 0 | 282,594 | 0 |
| XOMA CORP | COM | 98419J907 | 265 | 578 | SH | Call | DFND | 1 | 0 | 578 | 0 |
| XOMA CORP | COM | 98419J957 | 547 | 1,191 | SH | Put | DFND | 1 | 0 | 1,191 | 0 |
| ZIOPHARM ONCOLOGY INC | COM | 98973P901 | 269 | 668 | SH | Call | DFND | 1 | 0 | 668 | 0 |
