| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AASTROM BIOSCIENCES INC | COM | 00253U404 | 2,497 | 876,173 | SH | | DFND | 1 | 0 | 876,173 | 0 |
| ABBVIE INC | COM | 00287Y909 | 43,938 | 7,607 | SH | Call | DFND | 1 | 0 | 7,607 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 00404A109 | 16,424 | 663,324 | SH | | DFND | 1 | 0 | 663,324 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 00404A909 | 69,509 | 28,073 | SH | Call | DFND | 1 | 0 | 28,073 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 00404A959 | 2,530 | 1,022 | SH | Put | DFND | 1 | 0 | 1,022 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q201 | 579 | 57,971 | SH | | DFND | 1 | 0 | 57,971 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 14,187 | 14,215 | SH | Call | DFND | 1 | 0 | 14,215 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 3,930 | 3,938 | SH | Put | DFND | 1 | 0 | 3,938 | 0 |
| ACTAVIS PLC SHS | SHS | G0083B108 | 15,016 | 62,233 | SH | | DFND | 1 | 0 | 62,233 | 0 |
| ACTAVIS PLC SHS | SHS | G0083B908 | 36,988 | 1,533 | SH | Call | DFND | 1 | 0 | 1,533 | 0 |
| ACTAVIS PLC SHS | SHS | G0083B958 | 48,449 | 2,008 | SH | Put | DFND | 1 | 0 | 2,008 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U901 | 28,667 | 5,031 | SH | Call | DFND | 1 | 0 | 5,031 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U951 | 9,476 | 1,663 | SH | Put | DFND | 1 | 0 | 1,663 | 0 |
| ALCOBRA LTD | SHS | M2239P909 | 900 | 583 | SH | Call | DFND | 1 | 0 | 583 | 0 |
| ALCOBRA LTD | SHS | M2239P959 | 5,649 | 3,659 | SH | Put | DFND | 1 | 0 | 3,659 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384909 | 475 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALIMERA SCIENCES INC | COM | 016259103 | 271 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| ALIMERA SCIENCES INC | COM | 016259903 | 376 | 693 | SH | Call | DFND | 1 | 0 | 693 | 0 |
| ALIMERA SCIENCES INC | COM | 016259953 | 266 | 490 | SH | Put | DFND | 1 | 0 | 490 | 0 |
| ALKERMES PLC | SHS | G01767105 | 1,702 | 39,695 | SH | | DFND | 1 | 0 | 39,695 | 0 |
| ALKERMES PLC | SHS | G01767905 | 5,740 | 1,339 | SH | Call | DFND | 1 | 0 | 1,339 | 0 |
| ALKERMES PLC | SHS | G01767955 | 3,061 | 714 | SH | Put | DFND | 1 | 0 | 714 | 0 |
| ALLERGAN INC | COM | 018490902 | 2,512 | 141 | SH | Call | DFND | 1 | 0 | 141 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 18,393 | 2,355 | SH | Call | DFND | 1 | 0 | 2,355 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q957 | 6,037 | 773 | SH | Put | DFND | 1 | 0 | 773 | 0 |
| AMERICAN TOWER CORP | COM | 03027X900 | 2,743 | 293 | SH | Call | DFND | 1 | 0 | 293 | 0 |
| AMERICAN TOWER CORP | COM | 03027X950 | 234 | 25 | SH | Put | DFND | 1 | 0 | 25 | 0 |
| AMGEN INC | COM | 031162900 | 15,493 | 1,103 | SH | Call | DFND | 1 | 0 | 1,103 | 0 |
| AMGEN INC | COM | 031162950 | 7,711 | 549 | SH | Put | DFND | 1 | 0 | 549 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T109 | 497 | 140,800 | SH | | DFND | 1 | 0 | 140,800 | 0 |
| AMPIO PHARMACEUTICALS INC | COM | 03209T959 | 497 | 1,408 | SH | Put | DFND | 1 | 0 | 1,408 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U901 | 131 | 683 | SH | Call | DFND | 1 | 0 | 683 | 0 |
| APPLE INC | COM | 037833900 | 3,023 | 300 | SH | Call | DFND | 1 | 0 | 300 | 0 |
| APPLE INC | COM | 037833950 | 3,023 | 300 | SH | Put | DFND | 1 | 0 | 300 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V109 | 26 | 17,800 | SH | | DFND | 1 | 0 | 17,800 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V959 | 130 | 864 | SH | Put | DFND | 1 | 0 | 864 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047102 | 1,151 | 274,782 | SH | | DFND | 1 | 0 | 274,782 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 966 | 2,306 | SH | Call | DFND | 1 | 0 | 2,306 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047952 | 1,738 | 4,149 | SH | Put | DFND | 1 | 0 | 4,149 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A100 | 1,093 | 202,445 | SH | | DFND | 1 | 0 | 202,445 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 1,227 | 2,272 | SH | Call | DFND | 1 | 0 | 2,272 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 1,316 | 2,437 | SH | Put | DFND | 1 | 0 | 2,437 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797209 | 451 | 30,513 | SH | | DFND | 1 | 0 | 30,513 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 042797959 | 1,477 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| ASTRAZENECA PLC | ADR | 046353108 | 21 | 215,323 | SH | | DFND | 1 | 0 | 215,323 | 0 |
| ASTRAZENECA PLC | ADR | 046353908 | 18,874 | 1,503 | SH | Call | DFND | 1 | 0 | 1,503 | 0 |
| ASTRAZENECA PLC | ADR | 046353958 | 40,365 | 4,639 | SH | Put | DFND | 1 | 0 | 4,639 | 0 |
| ATHERSYS INC | COM | 04744L906 | 90 | 647 | SH | Call | DFND | 1 | 0 | 647 | 0 |
| ATHERSYS INC | COM | 04744L956 | 142 | 1,023 | SH | Put | DFND | 1 | 0 | 1,023 | 0 |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 3,080 | 120,000 | SH | | DFND | 1 | 0 | 120,000 | 0 |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D907 | 11,483 | 3,847 | SH | Call | DFND | 1 | 0 | 3,847 | 0 |
| AVALANCHE BIOTECHNOLOGIES IN | COM | 05337G107 | 1,710 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| AVANIR PHARMACEUTICALS INC | CL A | 05348P901 | 2,839 | 2,382 | SH | Call | DFND | 1 | 0 | 2,382 | 0 |
| BAXANO SURGICAL INC | COM | 071773105 | 232 | 1,269,646 | SH | | DFND | 1 | 0 | 1,269,646 | 0 |
| BIODEL INC | COM | 09064M204 | 2,493 | 1,492,803 | SH | | DFND | 1 | 0 | 1,492,803 | 0 |
| BIODEL INC | COM | 09064M954 | 30 | 182 | SH | Put | DFND | 1 | 0 | 182 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 138,279 | 4,180 | SH | Call | DFND | 1 | 0 | 4,180 | 0 |
| BIOGEN IDEC INC | COM | 09062X953 | 10,817 | 327 | SH | Put | DFND | 1 | 0 | 327 | 0 |
| BIOLINERX LTD | ADR | 0971M106 | 2,902 | 1,884,410 | SH | | DFND | 1 | 0 | 1,884,410 | 0 |
| BLUEBIRD BIO INC | COM | 09609G100 | 882 | 24,574 | SH | | DFND | 1 | 0 | 24,574 | 0 |
| BLUEBIRD BIO INC | COM | 09609G900 | 3,563 | 993 | SH | Call | DFND | 1 | 0 | 993 | 0 |
| BRAINSTORM CELL THERAPEUTICS | COM | 10501E201 | 3,322 | 808,256 | SH | | DFND | 1 | 0 | 808,256 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 46,748 | 9,134 | SH | Call | DFND | 1 | 0 | 9,134 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122958 | 12,073 | 2,359 | SH | Put | DFND | 1 | 0 | 2,359 | 0 |
| CARDICA INC | COM | 14141R101 | 1,090 | 1,019,137 | SH | | DFND | 1 | 0 | 1,019,137 | 0 |
| CASI PHARMACEUTICALS INC | COM | 14757U109 | 1,411 | 788,485 | SH | | DFND | 1 | 0 | 788,485 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 271 | 107,129 | SH | | DFND | 1 | 0 | 107,129 | 0 |
| CELGENE CORP | COM | 151020904 | 21,989 | 2,320 | SH | Call | DFND | 1 | 0 | 2,320 | 0 |
| CELGENE CORP | COM | 151020954 | 26,046 | 2,748 | SH | Put | DFND | 1 | 0 | 2,748 | 0 |
| CELLADON CORP | COM | 15117E107 | 743 | 71,000 | SH | | DFND | 1 | 0 | 71,000 | 0 |
| CELLECTAR BIOSCIENCES INC | COM | 15117F203 | 1,658 | 730,609 | SH | | DFND | 1 | 0 | 730,609 | 0 |
| CELLECTAR BIOSCIENCES-WARRANTS | *W | 15117F112 | 365 | 608,800 | SH | | DFND | 1 | 0 | 608,800 | 0 |
| CEL-SCI CORP | COM | 150837508 | 12 | 12,888 | SH | | DFND | 1 | 0 | 12,888 | 0 |
| CEL-SCI CORP-WARRANTS | *W | 150837177 | 874 | 3,972,437 | SH | | DFND | 1 | 0 | 3,972,437 | 0 |
| CELSION CORP | COM | 15117N404 | 324 | 109,435 | SH | | DFND | 1 | 0 | 109,435 | 0 |
| CELSION CORP | COM | 15117N954 | 2,415 | 8,160 | SH | Put | DFND | 1 | 0 | 8,160 | 0 |
| CELSUS THERAPEUTICS | ADR | 15119A202 | 5,059 | 860,453 | SH | | DFND | 1 | 0 | 860,453 | 0 |
| CEMPRA INC | COM | 15130J109 | 776 | 70,804 | SH | | DFND | 1 | 0 | 70,804 | 0 |
| CEMPRA INC | COM | 15130J909 | 1,247 | 1,138 | SH | Call | DFND | 1 | 0 | 1,138 | 0 |
| CEMPRA INC | COM | 15130J959 | 1,168 | 1,066 | SH | Put | DFND | 1 | 0 | 1,066 | 0 |
| CERES INC | COM | 156773103 | 205 | 500,000 | SH | | DFND | 1 | 0 | 500,000 | 0 |
| CESCA THERAPEUTICS INC | COM | 157131103 | 4,332 | 3,551,081 | SH | | DFND | 1 | 0 | 3,551,081 | 0 |
| CLEVELAND BIOLABS INC | COM | 185860103 | 404 | 881,056 | SH | | DFND | 1 | 0 | 881,056 | 0 |
| COMPUGEN LTD | ORD | M25722105 | 29 | 3,400 | SH | | DFND | 1 | 0 | 3,400 | 0 |
| CONATUS PHARMACEUTICALS INC | COM | 20600T108 | 294 | 48,000 | SH | | DFND | 1 | 0 | 48,000 | 0 |
| CORIUM INTERNATIONAL INC | COM | 21887L107 | 803 | 130,732 | SH | | DFND | 1 | 0 | 130,732 | 0 |
| COVIDIEN PLC | SHS | G2554F113 | 5,775 | 66,752 | SH | | DFND | 1 | 0 | 66,752 | 0 |
| COVIDIEN PLC | SHS | G2554F953 | 7,890 | 912 | SH | Put | DFND | 1 | 0 | 912 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L906 | 420 | 1,735 | SH | Call | DFND | 1 | 0 | 1,735 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L956 | 62 | 256 | SH | Put | DFND | 1 | 0 | 256 | 0 |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 1,709 | 249,900 | SH | | DFND | 1 | 0 | 249,900 | 0 |
| CYTORI THERAPEUTICS INC | COM | 23283K105 | 2,363 | 3,495,368 | SH | | DFND | 1 | 0 | 3,495,368 | 0 |
| DEPOMED INC NOTE 2.5% | NOTE | 249908AA2 | 316,689 | 30,000 | SH | | DFND | 1 | 0 | 30,000 | 0 |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 3,310 | 260,000 | SH | | DFND | 1 | 0 | 260,000 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668403 | 120 | 65,000 | SH | | DFND | 1 | 0 | 65,000 | 0 |
| DISCOVERY LABORATORIES INC | COM | 254668903 | 262 | 1,424 | SH | Call | DFND | 1 | 0 | 1,424 | 0 |
| DYAX CORP | COM | 26746E103 | 882 | 872 | SH | Call | DFND | 1 | 0 | 872 | 0 |
| EDAP TMS SA | ADR | 268311107 | 19 | 14,524 | SH | | DFND | 1 | 0 | 14,524 | 0 |
| EDAP TMS SA | ADR | 268311907 | 55 | 423 | SH | Call | DFND | 1 | 0 | 423 | 0 |
| EDAP TMS SA | ADR | 268311957 | 18 | 139 | SH | Put | DFND | 1 | 0 | 139 | 0 |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 223 | 19,997 | SH | | DFND | 1 | 0 | 19,997 | 0 |
| ELI LILLY & CO | COM | 532457908 | 28,268 | 4,359 | SH | Call | DFND | 1 | 0 | 4,359 | 0 |
| ENANTA PHARMACEUTICALS INC | COM | 29251M906 | 514 | 130 | SH | Call | DFND | 1 | 0 | 130 | 0 |
| ENDOCYTE INC | COM | 29269A102 | 69 | 11,300 | SH | | DFND | 1 | 0 | 11,300 | 0 |
| ENDOCYTE INC | COM | 29269A902 | 97 | 159 | SH | Call | DFND | 1 | 0 | 159 | 0 |
| ENDOCYTE INC | COM | 29269A952 | 525 | 863 | SH | Put | DFND | 1 | 0 | 863 | 0 |
| EXACT SCIENCES CORP | COM | 30063P105 | 425 | 21,952 | SH | | DFND | 1 | 0 | 21,952 | 0 |
| EXACT SCIENCES CORP | COM | 30063P955 | 2,236 | 1,154 | SH | Put | DFND | 1 | 0 | 1,154 | 0 |
| EXELIXIS INC | COM | 30161Q104 | 430 | 281,322 | SH | | DFND | 1 | 0 | 281,322 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 496 | 3,244 | SH | Call | DFND | 1 | 0 | 3,244 | 0 |
| EXELIXIS INC | COM | 30161Q954 | 438 | 2,864 | SH | Put | DFND | 1 | 0 | 2,864 | 0 |
| FOAMIX PHARMACEUTICALS LTD | COM | M46135105 | 1,478 | 271,200 | SH | | DFND | 1 | 0 | 271,200 | 0 |
| GALENA BIOPHARMA INC | COM | 363256108 | 582 | 282,704 | SH | | DFND | 1 | 0 | 282,704 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 1,615 | 7,839 | SH | Put | DFND | 1 | 0 | 7,839 | 0 |
| GERON CORP | COM | 374163903 | 2,454 | 4,859 | SH | Call | DFND | 1 | 0 | 4,859 | 0 |
| GERON CORP | COM | 374163953 | 65 | 107 | SH | Put | DFND | 1 | 0 | 107 | 0 |
| GEVO INC | COM | 374396109 | 1,524 | 4,448,220 | SH | | DFND | 1 | 0 | 4,448,220 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 24,356 | 2,288 | SH | Call | DFND | 1 | 0 | 2,288 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 146,933 | 13,803 | SH | Put | DFND | 1 | 0 | 13,803 | 0 |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 2,021 | 250 | SH | Call | DFND | 1 | 0 | 250 | 0 |
| HARVARD APPARATUS REGENERATIVE TECH. | COM | 41690A106 | 451 | 55,621 | SH | | DFND | 1 | 0 | 55,621 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 | 1,541 | 185,000 | SH | | DFND | 1 | 0 | 185,000 | 0 |
| HORIZON PHARMA ORD | SHS | G4617B905 | 6,095 | 4,963 | SH | Call | DFND | 1 | 0 | 4,963 | 0 |
| HORIZON PHARMA ORD | SHS | G4617B955 | 296 | 241 | SH | Put | DFND | 1 | 0 | 241 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K306 | 1,923 | 839,923 | SH | | DFND | 1 | 0 | 839,923 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K906 | 808 | 3,529 | SH | Call | DFND | 1 | 0 | 3,529 | 0 |
| IGNYTA INC | COM | 451731103 | 1,851 | 229,701 | SH | | DFND | 1 | 0 | 229,701 | 0 |
| IMMUNOCELLULAR THERAPEUTICS LTD | COM | 452536955 | 21 | 237 | SH | Put | DFND | 1 | 0 | 237 | 0 |
| INCYTE CORP | COM | 45337C902 | 2,114 | 431 | SH | Call | DFND | 1 | 0 | 431 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 73 | 5,438 | SH | | DFND | 1 | 0 | 5,438 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G903 | 1,326 | 988 | SH | Call | DFND | 1 | 0 | 988 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G953 | 1,813 | 1,351 | SH | Put | DFND | 1 | 0 | 1,351 | 0 |
| INSMED INC | COM | 457669307 | 131 | 10,000 | SH | | DFND | 1 | 0 | 10,000 | 0 |
| INTELLIPHARMACEUTICS INTERNAINC COM | COM | 458173951 | 207 | 689 | SH | Put | DFND | 1 | 0 | 689 | 0 |
| INTERCEPT PHARMACEUTICALS INC | COM | 45845P908 | 1,302 | 55 | SH | Call | DFND | 1 | 0 | 55 | 0 |
| INTEROIL CORP | COM | 460951106 | 12,153 | 223,979 | SH | | DFND | 1 | 0 | 223,979 | 0 |
| INTEROIL CORP | COM | 460951956 | 23,603 | 4,350 | SH | Put | DFND | 1 | 0 | 4,350 | 0 |
| INTREXON CORP | COM | 46122T102 | 471 | 25,333 | SH | | DFND | 1 | 0 | 25,333 | 0 |
| INTREXON CORP | COM | 46122T902 | 1,858 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| INTREXON CORP | COM | 46122T952 | 1,858 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| IRONWOOD PHARMACEUTICALS INC | COM | 46333X908 | 464 | 142 | SH | Call | DFND | 1 | 0 | 142 | 0 |
| ISHARES RUSSELL 2000 ETF | ETF | 464287955 | 57,835 | 5,289 | SH | Put | DFND | 1 | 0 | 5,289 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330909 | 1,476 | 380 | SH | Call | DFND | 1 | 0 | 380 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515901 | 344 | 250 | SH | Call | DFND | 1 | 0 | 250 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 138 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| LPATH INC | COM | 548910306 | 5,731 | 1,628,100 | SH | | DFND | 1 | 0 | 1,628,100 | 0 |
| MANNKIND CORP | COM | 56400P201 | 3,457 | 584,918 | SH | | DFND | 1 | 0 | 584,918 | 0 |
| MANNKIND CORP | COM | 56400P901 | 19,763 | 33,440 | SH | Call | DFND | 1 | 0 | 33,440 | 0 |
| MANNKIND CORP | COM | 56400P951 | 15,099 | 25,548 | SH | Put | DFND | 1 | 0 | 25,548 | 0 |
| MEDGENICS INC | COM | 58436Q953 | 75 | 145 | SH | Put | DFND | 1 | 0 | 145 | 0 |
| MEDGENICS INC-WARRANTS | *W | 58436Q112 | 673 | 841,712 | SH | | DFND | 1 | 0 | 841,712 | 0 |
| MEDICINES CO | COM | 584688955 | 315 | 141 | SH | Put | DFND | 1 | 0 | 141 | 0 |
| MEDIVATION INC | COM | 58501N901 | 17,678 | 1,788 | SH | Call | DFND | 1 | 0 | 1,788 | 0 |
| MEDIVATION INC | COM | 58501N951 | 257 | 26 | SH | Put | DFND | 1 | 0 | 26 | 0 |
| MEI PHARMA INC | COM | 55279B202 | 1,820 | 263,723 | SH | | DFND | 1 | 0 | 263,723 | 0 |
| MELA SCIENCES INC | COM | 55277R308 | 128 | 74,188 | SH | | DFND | 1 | 0 | 74,188 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 37,465 | 6,320 | SH | Call | DFND | 1 | 0 | 6,320 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 16,587 | 2,798 | SH | Put | DFND | 1 | 0 | 2,798 | 0 |
| NEOSTEM INC | COM | 640650404 | 63 | 11,423 | SH | | DFND | 1 | 0 | 11,423 | 0 |
| NEOSTEM INC | COM | 640650904 | 192 | 348 | SH | Call | DFND | 1 | 0 | 348 | 0 |
| NEOSTEM INC | COM | 640650954 | 145 | 263 | SH | Put | DFND | 1 | 0 | 263 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 2,625 | 1,675 | SH | Call | DFND | 1 | 0 | 1,675 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C959 | 2,059 | 1,314 | SH | Put | DFND | 1 | 0 | 1,314 | 0 |
| NEUROMETRIX INC | COM | 641255302 | 561 | 311,530 | SH | | DFND | 1 | 0 | 311,530 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 1,687 | 3,353 | SH | Put | DFND | 1 | 0 | 3,353 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 375 | 14,408 | SH | | DFND | 1 | 0 | 14,408 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P903 | 1,300 | 500 | SH | Call | DFND | 1 | 0 | 500 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P953 | 1,336 | 514 | SH | Put | DFND | 1 | 0 | 514 | 0 |
| OCERA THERAPEUTICS INC | COM | 67221A108 | 2,067 | 421,747 | SH | | DFND | 1 | 0 | 421,747 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 | 4,448 | 297,107 | SH | | DFND | 1 | 0 | 297,107 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H200 | 575 | 79,300 | SH | | DFND | 1 | 0 | 79,300 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H900 | 62 | 855 | SH | Call | DFND | 1 | 0 | 855 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A106 | 2,102 | 787,088 | SH | | DFND | 1 | 0 | 787,088 | 0 |
| ONCOTHYREON INC | COM | 682324108 | 2,181 | 1,136,094 | SH | | DFND | 1 | 0 | 1,136,094 | 0 |
| ONCOTHYREON INC | COM | 682324908 | 32 | 168 | SH | Call | DFND | 1 | 0 | 168 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 18,997 | 22,323 | SH | Call | DFND | 1 | 0 | 22,323 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 1,489 | 1,750 | SH | Put | DFND | 1 | 0 | 1,750 | 0 |
| ORIENT PAPER INC | COM | 68619F205 | 1,426 | 1,033,214 | SH | | DFND | 1 | 0 | 1,033,214 | 0 |
| OXIGENE INC | COM | 691828404 | 2,554 | 1,187,598 | SH | | DFND | 1 | 0 | 1,187,598 | 0 |
| OXIGENE INC | COM | 691828904 | 74 | 344 | SH | Call | DFND | 1 | 0 | 344 | 0 |
| OXIGENE INC | COM | 691828954 | 48 | 222 | SH | Put | DFND | 1 | 0 | 222 | 0 |
| PACIFIC ETHANOL INC | COM | 69423U305 | 320 | 22,900 | SH | | DFND | 1 | 0 | 22,900 | 0 |
| PACIFIC ETHANOL INC | COM | 69423U955 | 443 | 317 | SH | Put | DFND | 1 | 0 | 317 | 0 |
| PFIZER INC | COM | 717081903 | 15,258 | 5,160 | SH | Call | DFND | 1 | 0 | 5,160 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 341 | 29 | SH | Put | DFND | 1 | 0 | 29 | 0 |
| PHARMATHENE INC | COM | 71714G902 | 219 | 1,230 | SH | Call | DFND | 1 | 0 | 1,230 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R102 | 340 | 119,011 | SH | | DFND | 1 | 0 | 119,011 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 943 | 3,296 | SH | Put | DFND | 1 | 0 | 3,296 | 0 |
| PROQR THERAPEUTICS NV | SHS | N71542109 | 6,554 | 381,249 | SH | | DFND | 1 | 0 | 381,249 | 0 |
| PSIVIDA CORP | COM | 74440J101 | 394 | 89,078 | SH | | DFND | 1 | 0 | 89,078 | 0 |
| PSIVIDA CORP | COM | 74440J901 | 155 | 350 | SH | Call | DFND | 1 | 0 | 350 | 0 |
| PSIVIDA CORP | COM | 74440J951 | 393 | 890 | SH | Put | DFND | 1 | 0 | 890 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V907 | 8,541 | 358 | SH | Call | DFND | 1 | 0 | 358 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V957 | 5,583 | 234 | SH | Put | DFND | 1 | 0 | 234 | 0 |
| QUEST RESOURCE HOLDING CORP | COM | 74836W104 | 3,997 | 2,323,783 | SH | | DFND | 1 | 0 | 2,323,783 | 0 |
| RECEPTOS INC | COM | 756207906 | 627 | 101 | SH | Call | DFND | 1 | 0 | 101 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 821 | 277,502 | SH | | DFND | 1 | 0 | 277,502 | 0 |
| REGADO BIOSCIENCE INC | COM | 75874Q107 | 1,143 | 1,011,550 | SH | | DFND | 1 | 0 | 1,011,550 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 9,734 | 270 | SH | Call | DFND | 1 | 0 | 270 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H209 | 2,927 | 295,621 | SH | | DFND | 1 | 0 | 295,621 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H909 | 1,076 | 1,087 | SH | Call | DFND | 1 | 0 | 1,087 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 3,425 | 3,460 | SH | Put | DFND | 1 | 0 | 3,460 | 0 |
| RETROPHIN INC | COM | 761299906 | 1,542 | 1,710 | SH | Call | DFND | 1 | 0 | 1,710 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 | 1,852 | 95,800 | SH | | DFND | 1 | 0 | 95,800 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374102 | 1,934 | 211,635 | SH | | DFND | 1 | 0 | 211,635 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 4,758 | 5,206 | SH | Put | DFND | 1 | 0 | 5,206 | 0 |
| SALIX PHARMACEUTICALS LTD | COM | 795435106 | 312 | 2,000 | SH | | DFND | 1 | 0 | 2,000 | 0 |
| SALIX PHARMACEUTICALS LTD | COM | 795435906 | 3,125 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 4,531 | 420,123 | SH | | DFND | 1 | 0 | 420,123 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677906 | 10,798 | 10,012 | SH | Call | DFND | 1 | 0 | 10,012 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,251 | 106,663 | SH | | DFND | 1 | 0 | 106,663 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 7,541 | 3,574 | SH | Call | DFND | 1 | 0 | 3,574 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 893 | 423 | SH | Put | DFND | 1 | 0 | 423 | 0 |
| SEATTLE GENETICS INC | COM | 812578102 | 1,935 | 52,047 | SH | | DFND | 1 | 0 | 52,047 | 0 |
| SEATTLE GENETICS INC | COM | 812578902 | 784 | 211 | SH | Call | DFND | 1 | 0 | 211 | 0 |
| SEATTLE GENETICS INC | COM | 812578952 | 2,870 | 772 | SH | Put | DFND | 1 | 0 | 772 | 0 |
| SEMLER SCIENTIFIC INC | COM | 81684M104 | 789 | 281,951 | SH | | DFND | 1 | 0 | 281,951 | 0 |
| SHIRE PLC | ADR | 82481R106 | 4,741 | 9,955 | SH | | DFND | 1 | 0 | 9,955 | 0 |
| SHIRE PLC | ADR | 82481R956 | 2,579 | 183 | SH | Put | DFND | 1 | 0 | 183 | 0 |
| SKYSTAR BIO-PHARMACEUTICAL | COM | 830884300 | 1,211 | 289,110 | SH | | DFND | 1 | 0 | 289,110 | 0 |
| SPDR S&P 500 ETF TRUST | TR UNIT | 78462F953 | 86,413 | 4,386 | SH | Put | DFND | 1 | 0 | 4,386 | 0 |
| STEMCELLS INC | COM | 85857R204 | 6,081 | 4,826,383 | SH | | DFND | 1 | 0 | 4,826,383 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328901 | 2,912 | 4,079 | SH | Call | DFND | 1 | 0 | 4,079 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328951 | 650 | 910 | SH | Put | DFND | 1 | 0 | 910 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A103 | 9,987 | 145,200 | SH | | DFND | 1 | 0 | 145,200 | 0 |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A953 | 9,987 | 1,452 | SH | Put | DFND | 1 | 0 | 1,452 | 0 |
| SYNERGY PHARMACEUTICALS - WARRANTS | *W | 871639118 | 321 | 386,391 | SH | | DFND | 1 | 0 | 386,391 | 0 |
| T2 BIOSYSTEMS INC | COM | 89853L104 | 1,906 | 105,367 | SH | | DFND | 1 | 0 | 105,367 | 0 |
| TEKMIRA PHARMACEUTICALS CORP. | COM | 87911B909 | 1,867 | 883 | SH | Call | DFND | 1 | 0 | 883 | 0 |
| TEKMIRA PHARMACEUTICALS CORP. | COM | 87911B959 | 2,562 | 1,212 | SH | Put | DFND | 1 | 0 | 1,212 | 0 |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 11,006 | 2,800,500 | SH | | DFND | 1 | 0 | 2,800,500 | 0 |
| TESARO INC | COM | 881569907 | 4,326 | 1,607 | SH | Call | DFND | 1 | 0 | 1,607 | 0 |
| TESARO INC NOTE 3.00 % | NOTE | 881569AA5 | 313,125 | 30,000 | SH | | DFND | 1 | 0 | 30,000 | 0 |
| TESLA MOTORS INC | COM | 88160R101 | 7,927 | 32,663 | SH | | DFND | 1 | 0 | 32,663 | 0 |
| TESLA MOTORS INC | COM | 88160R951 | 28,175 | 1,161 | SH | Put | DFND | 1 | 0 | 1,161 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 5,612 | 1,044 | SH | Call | DFND | 1 | 0 | 1,044 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 7,611 | 1,416 | SH | Put | DFND | 1 | 0 | 1,416 | 0 |
| TONIX PHARMACEUTICALS HOLDING CORP | COM | 890260201 | 345 | 50,394 | SH | | DFND | 1 | 0 | 50,394 | 0 |
| TONIX PHARMACEUTICALS HOLDING CORP | COM | 890260901 | 171 | 249 | SH | Call | DFND | 1 | 0 | 249 | 0 |
| TONIX PHARMACEUTICALS HOLDING CORP | COM | 890260951 | 708 | 1,033 | SH | Put | DFND | 1 | 0 | 1,033 | 0 |
| TROVAGENE INC | COM | 897238309 | 92 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| TRUPANION INC | COM | 898202106 | 1,998 | 235,000 | SH | | DFND | 1 | 0 | 235,000 | 0 |
| UNIQURE B.V. | SHS | N90064101 | 620 | 67,313 | SH | | DFND | 1 | 0 | 67,313 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 11,193 | 870 | SH | Call | DFND | 1 | 0 | 870 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659108 | 847 | 81,600 | SH | | DFND | 1 | 0 | 81,600 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659908 | 1,999 | 3,316 | SH | Call | DFND | 1 | 0 | 3,316 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 254,596 | 22,669 | SH | Call | DFND | 1 | 0 | 22,669 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 107,728 | 9,592 | SH | Put | DFND | 1 | 0 | 9,592 | 0 |
| WAFERGEN BIO-SYSTEMS INC | COM | 93041P308 | 2,421 | 556,600 | SH | | DFND | 1 | 0 | 556,600 | 0 |
| XENCOR INC | COM | 98401F105 | 1,595 | 171,275 | SH | | DFND | 1 | 0 | 171,275 | 0 |
| XOMA CORP | COM | 98419J107 | 1,828 | 434,318 | SH | | DFND | 1 | 0 | 434,318 | 0 |
| XOMA CORP | COM | 98419J907 | 1,301 | 3,090 | SH | Call | DFND | 1 | 0 | 3,090 | 0 |
| XOMA CORP | COM | 98419J957 | 513 | 1,218 | SH | Put | DFND | 1 | 0 | 1,218 | 0 |
| ZAFGEN INC | COM | 98885E103 | 6,437 | 327,566 | SH | | DFND | 1 | 0 | 327,566 | 0 |
