| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y909 | 83,711 | 12,792 | SH | Call | DFND | 1 | 0 | 12,792 | 0 |
| ABBVIE INC | COM | 00287Y959 | 5,052 | 772 | SH | Put | DFND | 1 | 0 | 772 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 27,446 | 864,437 | SH | | DFND | 1 | 0 | 864,437 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 90,056 | 28,364 | SH | Call | DFND | 1 | 0 | 28,364 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225958 | 3,089 | 973 | SH | Put | DFND | 1 | 0 | 973 | 0 |
| ACHILLION PHARMACEUTICALS | COM | 00448Q201 | 12,301 | 1,004,187 | SH | | DFND | 1 | 0 | 1,004,187 | 0 |
| ACHILLION PHARMACEUTICALS | COM | 00448Q901 | 3,331 | 2,719 | SH | Call | DFND | 1 | 0 | 2,719 | 0 |
| ACHILLION PHARMACEUTICALS | COM | 00448Q951 | 363 | 296 | SH | Put | DFND | 1 | 0 | 296 | 0 |
| ACTAVIS PLC | SHS | G0083B108 | 16,778 | 65,181 | SH | | DFND | 1 | 0 | 65,181 | 0 |
| ACTAVIS PLC | SHS | G0083B108 | 59,668 | 2,318 | SH | Call | DFND | 1 | 0 | 2,318 | 0 |
| ACTAVIS PLC | SHS | G0083B958 | 25,895 | 1,006 | SH | Put | DFND | 1 | 0 | 1,006 | 0 |
| AEGERION PHARMACEUTICALS INC | COM | 00767E902 | 1,047 | 500 | SH | Call | DFND | 1 | 0 | 500 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U101 | 6,755 | 165,008 | SH | | DFND | 1 | 0 | 165,008 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U901 | 13,662 | 3,337 | SH | Call | DFND | 1 | 0 | 3,337 | 0 |
| AGILENT TECHNOLOGIES INC | COM | 00846U951 | 700 | 171 | SH | Put | DFND | 1 | 0 | 171 | 0 |
| AGIOS PHARMACEUTICALS INC | COM | 00847X904 | 359 | 32 | SH | Put | DFND | 1 | 0 | 32 | 0 |
| ALEXZA PHARMACEUTICALS INC | COM | 015384209 | 304 | 2,040 | SH | Call | DFND | 1 | 0 | 2,040 | 0 |
| ALKERMES PLC | SHS | G01767105 | 810 | 13,827 | SH | | DFND | 1 | 0 | 13,827 | 0 |
| ALKERMES PLC | SHS | G01767905 | 316 | 54 | SH | Call | DFND | 1 | 0 | 54 | 0 |
| ALKERMES PLC | SHS | G01767955 | 7,355 | 1,256 | SH | Put | DFND | 1 | 0 | 1,256 | 0 |
| ALLERGAN INC | COM | 018490902 | 31,889 | 1,500 | SH | Call | DFND | 1 | 0 | 1,500 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 6,848 | 706 | SH | Call | DFND | 1 | 0 | 706 | 0 |
| AMERICAN TOWER CORP | COM | 03027X900 | 4,567 | 462 | SH | Call | DFND | 1 | 0 | 462 | 0 |
| AMERICAN TOWER CORP | COM | 03027X950 | 247 | 25 | SH | Put | DFND | 1 | 0 | 25 | 0 |
| AMGEN INC | COM | 031162900 | 9,239 | 580 | SH | Call | DFND | 1 | 0 | 580 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 2,053 | 246,697 | SH | | DFND | 1 | 0 | 246,697 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W909 | 454 | 546 | SH | Call | DFND | 1 | 0 | 546 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W959 | 1,329 | 1,597 | SH | Put | DFND | 1 | 0 | 1,597 | 0 |
| ARENA PHARMACEUTICALS INC | COM | 040047902 | 45 | 130 | SH | Call | DFND | 1 | 0 | 130 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A100 | 439 | 63,888 | SH | | DFND | 1 | 0 | 63,888 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A900 | 178 | 259 | SH | Call | DFND | 1 | 0 | 259 | 0 |
| ARIAD PHARMACEUTICALS INC | COM | 04033A950 | 1,588 | 2,311 | SH | Put | DFND | 1 | 0 | 2,311 | 0 |
| ARROWHEAD RESEARCH CORP | COM | 42797959 | 537 | 727 | SH | Put | DFND | 1 | 0 | 727 | 0 |
| ASTRAZENECA PLC | ADR | 046353108 | 13,517 | 192,055 | SH | | DFND | 1 | 0 | 192,055 | 0 |
| ASTRAZENECA PLC | ADR | 046353908 | 17,616 | 2,503 | SH | Call | DFND | 1 | 0 | 2,503 | 0 |
| ASTRAZENECA PLC | ADR | 046353958 | 30,531 | 4,338 | SH | Put | DFND | 1 | 0 | 4,338 | 0 |
| ATHERSYS INC | COM | 04744L906 | 80 | 508 | SH | Call | DFND | 1 | 0 | 508 | 0 |
| ATHERSYS INC | COM | 04744L956 | 253 | 1,599 | SH | Put | DFND | 1 | 0 | 1,599 | 0 |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 2,624 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| AUXILIUM PHARMACEUTICALS INC | COM | 05334D907 | 13,630 | 3,964 | SH | Call | DFND | 1 | 0 | 3,964 | 0 |
| AVALANCHE BIOTECHNOLOGIES IN | COM | 05337G107 | 7,711 | 142,803 | SH | | DFND | 1 | 0 | 142,803 | 0 |
| BELLICUM PHARMACEUTICALS INC | COM | 079481107 | 7,638 | 331,515 | SH | | DFND | 1 | 0 | 331,515 | 0 |
| BIODEL INC | COM | 09064M204 | 2,148 | 1,615,143 | SH | | DFND | 1 | 0 | 1,615,143 | 0 |
| BIODEL INC | COM | 09064M954 | 24 | 182 | SH | Put | DFND | 1 | 0 | 182 | 0 |
| BIOGEN IDEC INC | COM | 09062X903 | 155,468 | 4,580 | SH | Call | DFND | 1 | 0 | 4,580 | 0 |
| BIOGEN IDEC INC | COM | 09062X953 | 11,100 | 327 | SH | Put | DFND | 1 | 0 | 327 | 0 |
| BIOLINERX LTD | ADR | 09071M106 | 1,505 | 928,758 | SH | | DFND | 1 | 0 | 928,758 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 456 | 5,039 | SH | | DFND | 1 | 0 | 5,039 | 0 |
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G901 | 8,344 | 923 | SH | Call | DFND | 1 | 0 | 923 | 0 |
| BLUEBIRD BIO INC | COM | 09609G900 | 12,630 | 1,377 | SH | Call | DFND | 1 | 0 | 1,377 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122908 | 146,176 | 24,763 | SH | Call | DFND | 1 | 0 | 24,763 | 0 |
| BRISTOL MYERS SQUIBB CO | COM | 110122958 | 13,925 | 2,359 | SH | Put | DFND | 1 | 0 | 2,359 | 0 |
| CARDICA INC | COM | 14141R101 | 2,203 | 3,146,657 | SH | | DFND | 1 | 0 | 3,146,657 | 0 |
| CASI PHARMACEUTICALS INC | COM | 14757U109 | 1,112 | 836,092 | SH | | DFND | 1 | 0 | 836,092 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 275 | 140,234 | SH | | DFND | 1 | 0 | 140,234 | 0 |
| CELGENE CORP | COM | 151020904 | 3,132 | 280 | SH | Call | DFND | 1 | 0 | 280 | 0 |
| CELGENE CORP | COM | 151020954 | 783 | 70 | SH | Put | DFND | 1 | 0 | 70 | 0 |
| CELLECTAR BIOSCIENCES INC | COM | 15117F203 | 1,915 | 619,632 | SH | | DFND | 1 | 0 | 619,632 | 0 |
| CELLECTAR BIOSCIENCES-CW19 | *W | 15117F112 | 505 | 630,900 | SH | | DFND | 1 | 0 | 630,900 | 0 |
| CEL-SCI CORP | COM | 150837508 | 8 | 12,888 | SH | | DFND | 1 | 0 | 12,888 | 0 |
| CEL-SCI CORP-CW18 | *W | 150837177 | 438 | 3,064,745 | SH | | DFND | 1 | 0 | 3,064,745 | 0 |
| CELSION CORP | COM | 15117N404 | 1,056 | 453,356 | SH | | DFND | 1 | 0 | 453,356 | 0 |
| CELSION CORP | COM | 15117N954 | 907 | 3,892 | SH | Put | DFND | 1 | 0 | 3,892 | 0 |
| CELSUS THERAPEUTICS | ADR | 15119A202 | 2,586 | 538,703 | SH | | DFND | 1 | 0 | 538,703 | 0 |
| CEMPRA INC | COM | 15130J909 | 5,962 | 2,536 | SH | Call | DFND | 1 | 0 | 2,536 | 0 |
| CEMPRA INC | COM | 15130J959 | 4,895 | 2,082 | SH | Put | DFND | 1 | 0 | 2,082 | 0 |
| CERES INC | COM | 156773103 | 53 | 222,600 | SH | | DFND | 1 | 0 | 222,600 | 0 |
| CESCA THERAPEUTICS INC | COM | 157131103 | 3,775 | 3,701,695 | SH | | DFND | 1 | 0 | 3,701,695 | 0 |
| CLEVELAND BIOLABS INC | COM | 185860103 | 108 | 377,156 | SH | | DFND | 1 | 0 | 377,156 | 0 |
| COMMUNITY HEALTH SYSTEMS INC | COM | 203668108 | 2,320 | 43,027 | SH | | DFND | 1 | 0 | 43,027 | 0 |
| COMMUNITY HEALTH SYSTEMS INC | COM | 203668908 | 226 | 42 | SH | Call | DFND | 1 | 0 | 42 | 0 |
| COMMUNITY HEALTH SYSTEMS INC | COM | 203668958 | 8,503 | 1,577 | SH | Put | DFND | 1 | 0 | 1,577 | 0 |
| CONATUS PHARMACEUTICALS INC | COM | 20600T908 | 118 | 169 | SH | Call | DFND | 1 | 0 | 169 | 0 |
| COVIDIEN PLC | SHS | G2554F113 | 6,703 | 65,537 | SH | | DFND | 1 | 0 | 65,537 | 0 |
| COVIDIEN PLC | SHS | G2554F953 | 19,546 | 1,911 | SH | Put | DFND | 1 | 0 | 1,911 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L106 | 578 | 245,000 | SH | | DFND | 1 | 0 | 245,000 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L906 | 1,642 | 6,956 | SH | Call | DFND | 1 | 0 | 6,956 | 0 |
| CTI BIOPHARMA CORP | COM | 12648L956 | 60 | 256 | SH | Put | DFND | 1 | 0 | 256 | 0 |
| CUBIST PHARMACEUTICALS INC | COM | 229678907 | 8,787 | 873 | SH | Call | DFND | 1 | 0 | 873 | 0 |
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 991 | 100,800 | SH | | DFND | 1 | 0 | 100,800 | 0 |
| CYTORI THERAPEUTICS INC | COM | 23283K105 | 1,025 | 2,096,392 | SH | | DFND | 1 | 0 | 2,096,392 | 0 |
| CYTRX CORP | COM | 232828959 | 27 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| DANAHER CORP | COM | 235851102 | 4,719 | 55,053 | SH | | DFND | 1 | 0 | 55,053 | 0 |
| DANAHER CORP | COM | 235851902 | 8,571 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| DANAHER CORP | COM | 235851952 | 8,571 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| DARA BIOSCIENCES INC | COM | 23703P304 | 110 | 124,890 | SH | | DFND | 1 | 0 | 124,890 | 0 |
| DEPOMED INC 2.5% | NOTE | 249908AA2 | 323,814 | 3,000,000 | SH | | DFND | 1 | 0 | 3,000,000 | 0 |
| DERMIRA INC | COM | 24983L104 | 6,376 | 352,088 | SH | | DFND | 1 | 0 | 352,088 | 0 |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 2,403 | 145,919 | SH | | DFND | 1 | 0 | 145,919 | 0 |
| DYAX CORP | COM | 26746E903 | 4,772 | 3,394 | SH | Call | DFND | 1 | 0 | 3,394 | 0 |
| EDAP TMS SA | COM | 268311957 | 39 | 168 | SH | Put | DFND | 1 | 0 | 168 | 0 |
| ELEVEN BIOTHERAPEUTICS IN | COM | 286221106 | 8,286 | 697,470 | SH | | DFND | 1 | 0 | 697,470 | 0 |
| ELI LILLY & CO SHS | COM | 532457908 | 44,188 | 6,405 | SH | Call | DFND | 1 | 0 | 6,405 | 0 |
| ENDO INTERNATIONAL PLC | SHS | G30401906 | 1,825 | 253 | SH | Call | DFND | 1 | 0 | 253 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W905 | 833 | 206 | SH | Call | DFND | 1 | 0 | 206 | 0 |
| EXACT SCIENCES CORP | COM | 30063P955 | 2,942 | 1,072 | SH | Put | DFND | 1 | 0 | 1,072 | 0 |
| EXELIXIS INC | COM | 30161Q104 | 66 | 45,622 | SH | | DFND | 1 | 0 | 45,622 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 290 | 2,014 | SH | Call | DFND | 1 | 0 | 2,014 | 0 |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 1,145 | 163,300 | SH | | DFND | 1 | 0 | 163,300 | 0 |
| GALECTIN THERAPEUTICS INC | COM | 363225202 | 55 | 15,842 | SH | | DFND | 1 | 0 | 15,842 | 0 |
| GALENA BIOPHARMA INC | COM | 363256108 | 213 | 140,944 | SH | | DFND | 1 | 0 | 140,944 | 0 |
| GALENA BIOPHARMA INC | COM | 363256908 | 21 | 139 | SH | Call | DFND | 1 | 0 | 139 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 997 | 6,600 | SH | Put | DFND | 1 | 0 | 6,600 | 0 |
| GEVO INC | COM | 374396109 | 601 | 1,878,020 | SH | | DFND | 1 | 0 | 1,878,020 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 10,676 | 113,260 | SH | | DFND | 1 | 0 | 113,260 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 7,513 | 797 | SH | Call | DFND | 1 | 0 | 797 | 0 |
| GILEAD SCIENCES INC | COM | 375558953 | 114,856 | 12,185 | SH | Put | DFND | 1 | 0 | 12,185 | 0 |
| HCA HOLDINGS INC | COM | 40412C901 | 107 | 192 | SH | Call | DFND | 1 | 0 | 192 | 0 |
| HEARTWARE INTERNATIONAL INC | COM | 422368950 | 977 | 133 | SH | Put | DFND | 1 | 0 | 133 | 0 |
| HERON THERAPEUTICS INC | COM | 427746102 | 1,639 | 162,900 | SH | | DFND | 1 | 0 | 162,900 | 0 |
| HISTOGENICS CORP | COM | 43358V109 | 554 | 50,367 | SH | | DFND | 1 | 0 | 50,367 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B905 | 755 | 586 | SH | Call | DFND | 1 | 0 | 586 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B955 | 427 | 331 | SH | Put | DFND | 1 | 0 | 331 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K906 | 1,611 | 3,652 | SH | Call | DFND | 1 | 0 | 3,652 | 0 |
| IGNYTA INC | COM | 451731103 | 2,132 | 311,191 | SH | | DFND | 1 | 0 | 311,191 | 0 |
| INCYTE CORP | COM | 45337C102 | 772 | 10,564 | SH | | DFND | 1 | 0 | 10,564 | 0 |
| INCYTE CORP | COM | 45337C952 | 1,996 | 273 | SH | Put | DFND | 1 | 0 | 273 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G903 | 3,150 | 1,865 | SH | Call | DFND | 1 | 0 | 1,865 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G953 | 3,052 | 1,807 | SH | Put | DFND | 1 | 0 | 1,807 | 0 |
| INSMED INC | COM | 457669907 | 458 | 296 | SH | Call | DFND | 1 | 0 | 296 | 0 |
| INSPIREMD INC | COM | 45779A309 | 1,957 | 2,517,334 | SH | | DFND | 1 | 0 | 2,517,334 | 0 |
| INTELLIPHARMACEUTICS INTL INC | COM | 458173101 | 47 | 20,626 | SH | | DFND | 1 | 0 | 20,626 | 0 |
| INTELLIPHARMACEUTICS INTL INC | COM | 458173951 | 286 | 1,265 | SH | Put | DFND | 1 | 0 | 1,265 | 0 |
| INTEROIL CORP | COM | 460951106 | 13,189 | 270,330 | SH | | DFND | 1 | 0 | 270,330 | 0 |
| INTEROIL CORP | COM | 460951956 | 21,863 | 4,481 | SH | Put | DFND | 1 | 0 | 4,481 | 0 |
| INTREXON CORP | COM | 46122T902 | 2,753 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| INTREXON CORP | COM | 46122T952 | 2,717 | 987 | SH | Put | DFND | 1 | 0 | 987 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 65,747 | 5,494 | SH | Put | DFND | 1 | 0 | 5,494 | 0 |
| ISIS PHARMACEUTICALS INC | COM | 464330909 | 7,464 | 1,209 | SH | Call | DFND | 1 | 0 | 1,209 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515901 | 354 | 250 | SH | Call | DFND | 1 | 0 | 250 | 0 |
| KERYX BIOPHARMACEUTICALS | COM | 492515951 | 181 | 128 | SH | Put | DFND | 1 | 0 | 128 | 0 |
| KEYSIGHT TECHNOLOGIES INC | COM | 49338L103 | 2,836 | 83,978 | SH | | DFND | 1 | 0 | 83,978 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872104 | 184 | 202,700 | SH | | DFND | 1 | 0 | 202,700 | 0 |
| LPATH INC-CLASS A | COM | 548910306 | 3,520 | 1,248,097 | SH | | DFND | 1 | 0 | 1,248,097 | 0 |
| MANNKIND CORP | COM | 56400P201 | 4,489 | 860,751 | SH | | DFND | 1 | 0 | 860,751 | 0 |
| MANNKIND CORP | COM | 56400P901 | 5,981 | 11,468 | SH | Call | DFND | 1 | 0 | 11,468 | 0 |
| MANNKIND CORP | COM | 56400P951 | 9,838 | 18,865 | SH | Put | DFND | 1 | 0 | 18,865 | 0 |
| MAST THERAPEUTICS INC | COM | 576314108 | 1,982 | 3,539,779 | SH | | DFND | 1 | 0 | 3,539,779 | 0 |
| MEDGENICS INC-CW18 | *W | 58436Q112 | 922 | 1,271,240 | SH | | DFND | 1 | 0 | 1,271,240 | 0 |
| MEDICINES COMPANY | COM | 584688955 | 448 | 162 | SH | Put | DFND | 1 | 0 | 162 | 0 |
| MEDIVATION INC | COM | 58501N901 | 7,023 | 705 | SH | Call | DFND | 1 | 0 | 705 | 0 |
| MEI PHARMA INC | COM | 55279B202 | 2,562 | 600,000 | SH | | DFND | 1 | 0 | 600,000 | 0 |
| MELA SCIENCES INC | COM | 55277R308 | 719 | 599,262 | SH | | DFND | 1 | 0 | 599,262 | 0 |
| MERCK & CO. INC. | COM | 58933Y105 | 11,990 | 211,130 | SH | | DFND | 1 | 0 | 211,130 | 0 |
| MERCK & CO. INC. | COM | 58933Y905 | 8,388 | 1,477 | SH | Call | DFND | 1 | 0 | 1,477 | 0 |
| MERCK & CO. INC. | COM | 58933Y955 | 17,196 | 3,028 | SH | Put | DFND | 1 | 0 | 3,028 | 0 |
| MOBILEYE N.V. | SHS | N51488907 | 844 | 208 | SH | Call | DFND | 1 | 0 | 208 | 0 |
| MOBILEYE N.V. | SHS | N51488957 | 8,347 | 2,058 | SH | Put | DFND | 1 | 0 | 2,058 | 0 |
| NANOSPHERE INC | COM | 63009F105 | 872 | 2,225,081 | SH | | DFND | 1 | 0 | 2,225,081 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268908 | 3,689 | 2,380 | SH | Call | DFND | 1 | 0 | 2,380 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 3,559 | 1,593 | SH | Call | DFND | 1 | 0 | 1,593 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C959 | 3,606 | 1,614 | SH | Put | DFND | 1 | 0 | 1,614 | 0 |
| NEUROMETRIX INC | COM | 641255302 | 708 | 362,874 | SH | | DFND | 1 | 0 | 362,874 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 1,816 | 3,394 | SH | Put | DFND | 1 | 0 | 3,394 | 0 |
| NOVAVAX INC | COM | 670002904 | 2,062 | 3,478 | SH | Call | DFND | 1 | 0 | 3,478 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 1,491 | 41,670 | SH | | DFND | 1 | 0 | 41,670 | 0 |
| NPS PHARMACEUTICALS INC | COM | 62936P903 | 2,125 | 594 | SH | Call | DFND | 1 | 0 | 594 | 0 |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 2,739 | 429,945 | SH | | DFND | 1 | 0 | 429,945 | 0 |
| OCULAR THERAPEUTIX INC | COM | 67576A100 | 2,327 | 98,951 | SH | | DFND | 1 | 0 | 98,951 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H200 | 417 | 50,000 | SH | | DFND | 1 | 0 | 50,000 | 0 |
| ONCOGENEX PHARMACEUTICAL INC | COM | 68230A106 | 1,058 | 461,957 | SH | | DFND | 1 | 0 | 461,957 | 0 |
| ONCOTHYREON INC | COM | 682324108 | 1,377 | 724,500 | SH | | DFND | 1 | 0 | 724,500 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 21,825 | 21,847 | SH | Call | DFND | 1 | 0 | 21,847 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 1,276 | 1,277 | SH | Put | DFND | 1 | 0 | 1,277 | 0 |
| ORIENT PAPER INC | COM | 68619F205 | 265 | 238,800 | SH | | DFND | 1 | 0 | 238,800 | 0 |
| OXIGENE INC | COM | 691828404 | 1,260 | 782,674 | SH | | DFND | 1 | 0 | 782,674 | 0 |
| PEREGRINE PHARMACEUTICAL INC | COM | 713661304 | 5,196 | 237,797 | SH | | DFND | 1 | 0 | 237,797 | 0 |
| PERRIGO CO | COM | G97822903 | 4,797 | 287 | SH | Call | DFND | 1 | 0 | 287 | 0 |
| PFIZER INC | COM | 717081103 | 39,090 | 1,254,894 | SH | | DFND | 1 | 0 | 1,254,894 | 0 |
| PFIZER INC | COM | 717081903 | 24,319 | 7,807 | SH | Call | DFND | 1 | 0 | 7,807 | 0 |
| PFIZER INC | COM | 717081953 | 64,829 | 20,812 | SH | Put | DFND | 1 | 0 | 20,812 | 0 |
| PHARMACYCLICS INC | COM | 716933956 | 355 | 29 | SH | Put | DFND | 1 | 0 | 29 | 0 |
| PHARMATHENE INC | COM | 71714G902 | 221 | 1,220 | SH | Call | DFND | 1 | 0 | 1,220 | 0 |
| PLASMATECH BIOPHARMACEU-CW19 | *W | 72754H117 | 834 | 1,016,725 | SH | | DFND | 1 | 0 | 1,016,725 | 0 |
| PLASMATECH BIOPHARMACEUTICAL | COM | 72754H109 | 3,467 | 990,595 | SH | | DFND | 1 | 0 | 990,595 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 193 | 771 | SH | Put | DFND | 1 | 0 | 771 | 0 |
| PROGENICS PHARMACEUTICALS INC | COM | 743187106 | 484 | 63,999 | SH | | DFND | 1 | 0 | 63,999 | 0 |
| PROQR THRAPEUTICS NV | SHS | N71542109 | 5,484 | 253,083 | SH | | DFND | 1 | 0 | 253,083 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 3,570 | 18,860 | SH | | DFND | 1 | 0 | 18,860 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V957 | 7,874 | 416 | SH | Put | DFND | 1 | 0 | 416 | 0 |
| QUEST RESOURCE HOLDING CORP | COM | 74836W104 | 4,346 | 3,017,925 | SH | | DFND | 1 | 0 | 3,017,925 | 0 |
| RECEPTOS INC | COM | 756207906 | 1,593 | 130 | SH | Call | DFND | 1 | 0 | 130 | 0 |
| RECRO PHARMA INC | COM | 75629F109 | 2,196 | 767,836 | SH | | DFND | 1 | 0 | 767,836 | 0 |
| REGADO BIOSCIENCE INC | COM | 75874Q107 | 788 | 862,549 | SH | | DFND | 1 | 0 | 862,549 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 1,764 | 43 | SH | Call | DFND | 1 | 0 | 43 | 0 |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 5,651 | 352,278 | SH | | DFND | 1 | 0 | 352,278 | 0 |
| REGULUS THERAPEUTIC INC | COM | 75915K901 | 2,500 | 11,000 | SH | Call | DFND | 1 | 0 | 11,000 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H209 | 2,790 | 279,879 | SH | | DFND | 1 | 0 | 279,879 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H909 | 1,743 | 1,748 | SH | Call | DFND | 1 | 0 | 1,748 | 0 |
| REPROS THERAPEUTICS INC | COM | 76028H959 | 3,152 | 3,161 | SH | Put | DFND | 1 | 0 | 3,161 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 | 1,294 | 76,400 | SH | | DFND | 1 | 0 | 76,400 | 0 |
| RICEBRAN TECHNOLOGIES | COM | 762831204 | 3,325 | 799,200 | SH | | DFND | 1 | 0 | 799,200 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374102 | 2,827 | 275,000 | SH | | DFND | 1 | 0 | 275,000 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374902 | 4,159 | 4,046 | SH | Call | DFND | 1 | 0 | 4,046 | 0 |
| ROCKWELL MEDICAL INC | COM | 774374952 | 5,362 | 5,216 | SH | Put | DFND | 1 | 0 | 5,216 | 0 |
| SALIX PHARMACEUTICALS INC | COM | 795435906 | 1,816 | 158 | SH | Call | DFND | 1 | 0 | 158 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 4,464 | 293,500 | SH | | DFND | 1 | 0 | 293,500 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677906 | 15,466 | 10,168 | SH | Call | DFND | 1 | 0 | 10,168 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,519 | 105,000 | SH | | DFND | 1 | 0 | 105,000 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 9,510 | 6,572 | SH | Call | DFND | 1 | 0 | 6,572 | 0 |
| SEATTLE GENETICS INC | COM | 812578102 | 558 | 17,378 | SH | | DFND | 1 | 0 | 17,378 | 0 |
| SEATTLE GENETICS INC | COM | 812578902 | 678 | 211 | SH | Call | DFND | 1 | 0 | 211 | 0 |
| SEATTLE GENETICS INC | COM | 812578952 | 565 | 176 | SH | Put | DFND | 1 | 0 | 176 | 0 |
| SEMLER SCIENTIFIC INC | COM | 81684M104 | 226 | 115,423 | SH | | DFND | 1 | 0 | 115,423 | 0 |
| SHIRE PLC | ADR | 82481R106 | 2,051 | 9,652 | SH | | DFND | 1 | 0 | 9,652 | 0 |
| SHIRE PLC | ADR | 82481R956 | 3,889 | 183 | SH | Put | DFND | 1 | 0 | 183 | 0 |
| SKYSTAR BIO-PHARMACEUTICAL | COM | 830884300 | 1,333 | 314,367 | SH | | DFND | 1 | 0 | 314,367 | 0 |
| SPDR S&P 500 ETF TRUST UNIT | UNIT | 78462F953 | 155,933 | 7,588 | SH | Put | DFND | 1 | 0 | 7,588 | 0 |
| SPDR S&P BIOTECH ETF SHS | S&P BIOTECH | 78464A950 | 1,661 | 89 | SH | Put | DFND | 1 | 0 | 89 | 0 |
| STEMCELLS INC | COM | 85857R204 | 5,441 | 5,793,994 | SH | | DFND | 1 | 0 | 5,793,994 | 0 |
| SYNERGY PHARMACEUTICALS-CW16 | *W | 871639118 | 336 | 460,745 | SH | | DFND | 1 | 0 | 460,745 | 0 |
| T2 BIOSYSTEMS INC | COM | 89853L104 | 2,574 | 133,809 | SH | | DFND | 1 | 0 | 133,809 | 0 |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 9,026 | 2,350,567 | SH | | DFND | 1 | 0 | 2,350,567 | 0 |
| TENET HEALTHCARE CORP | COM | 88033G907 | 760 | 150 | SH | Call | DFND | 1 | 0 | 150 | 0 |
| TENET HEALTHCARE CORP | COM | 88033G957 | 4,479 | 884 | SH | Put | DFND | 1 | 0 | 884 | 0 |
| TESARO INC | COM | 881569907 | 1,986 | 534 | SH | Call | DFND | 1 | 0 | 534 | 0 |
| TESARO INC NOTE 3.00% | NOTE | 881569AA5 | 747,750 | 6,000,000 | SH | | DFND | 1 | 0 | 6,000,000 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 2,392 | 416 | SH | Call | DFND | 1 | 0 | 416 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 8,517 | 1,481 | SH | Put | DFND | 1 | 0 | 1,481 | 0 |
| THERAPEUTICSMD INC | COM | 88338N107 | 2,447 | 549,864 | SH | | DFND | 1 | 0 | 549,864 | 0 |
| THERAPEUTICSMD INC | COM | 88338N907 | 95 | 214 | SH | Call | DFND | 1 | 0 | 214 | 0 |
| THORATEC CORP | COM | 885175907 | 4,918 | 1,515 | SH | Call | DFND | 1 | 0 | 1,515 | 0 |
| TROVAGENE INC | COM | 897238309 | 86 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| TRUPANION INC | COM | 898202106 | 2,392 | 345,205 | SH | | DFND | 1 | 0 | 345,205 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 25,652 | 1,981 | SH | Call | DFND | 1 | 0 | 1,981 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659908 | 716 | 500 | SH | Call | DFND | 1 | 0 | 500 | 0 |
| VERICEL CORP | COM | 82346J108 | 948 | 311,800 | SH | | DFND | 1 | 0 | 311,800 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 46,106 | 3,881 | SH | Call | DFND | 1 | 0 | 3,881 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 113,953 | 9,592 | SH | Put | DFND | 1 | 0 | 9,592 | 0 |
| WAFERGEN BIO-SYSTEMS INC | COM | 93041P308 | 1,756 | 585,255 | SH | | DFND | 1 | 0 | 585,255 | 0 |
| XOMA CORP | COM | 98419J107 | 1,801 | 501,745 | SH | | DFND | 1 | 0 | 501,745 | 0 |
| XOMA CORP | COM | 98419J907 | 1,977 | 5,507 | SH | Call | DFND | 1 | 0 | 5,507 | 0 |
| XOMA CORP | COM | 98419J957 | 512 | 1,425 | SH | Put | DFND | 1 | 0 | 1,425 | 0 |
| ZAFGEN INC | COM | 98885E103 | 3,431 | 111,259 | SH | | DFND | 1 | 0 | 111,259 | 0 |
