Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y909	53,853	8,015	SH	Call	DFND	1	0	8,015	0
ABBVIE INC	COM	00287Y959	24,887	3,704	SH	Put	DFND	1	0	3,704	0
ABEONA THERAPEUTICS	COM	00289Y107	808	159,758	SH		DFND	1	0	159,758	0
ACADIA PHARMACEUTICALS INC	COM	004225908	4,913	1,173	SH	Call	DFND	1	0	1,173	0
ACADIA PHARMACEUTICALS INC	COM	004225958	1,801	430	SH	Put	DFND	1	0	430	0
ACELRX PHARMACEUTICALS INC	COM	00444T900	703	1,658	SH	Call	DFND	1	0	1,658	0
ACELRX PHARMACEUTICALS INC	COM	00444T950	79	186	SH	Put	DFND	1	0	186	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	605	142,700	SH		DFND	1	0	142,700	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	6,128	6,916	SH	Call	DFND	1	0	6,916	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q201	167	18,835	SH		DFND	1	0	18,835	0
ADVAXIS INC	COM	007624958	1,417	697	SH	Put	DFND	1	0	697	0
AFFILIATED MANAGERS GROUP INC	COM	008252958	5,203	238	SH	Put	DFND	1	0	238	0
AGIOS PHARMACEUTICALS INC	COM	00847X904	300	27	SH	Call	DFND	1	0	27	0
AGIOS PHARMACEUTICALS INC	COM	00847X954	3,734	336	SH	Put	DFND	1	0	336	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	2,072	266,953	SH		DFND	1	0	266,953	0
ALEXION PHARMACEUTICALS INC	COM	015351959	14,534	804	SH	Put	DFND	1	0	804	0
ALEXION PHARMACEUTICALS INC	COM	015351109	2,873	15,895	SH		DFND	1	0	15,895	0
ALLIQUA BIOMEDICAL INC	COM	019621200	791	150,000	SH		DFND	1	0	150,000	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q907	49,830	4,157	SH	Call	DFND	1	0	4,157	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q957	4,735	395	SH	Put	DFND	1	0	395	0
AMARIN CORPORATION PLC	ADR	023111906	658	2,673	SH	Call	DFND	1	0	2,673	0
AMARIN CORPORATION PLC	ADR	023111956	275	1,118	SH	Put	DFND	1	0	1,118	0
AMICUS THERAPEUTICS INC	COM	03152W909	896	633	SH	Call	DFND	1	0	633	0
AMICUS THERAPEUTICS INC	COM	03152W959	1,779	1,257	SH	Put	DFND	1	0	1,257	0
ANACOR PHARMACEUTICALS INC	COM	032420901	2,625	339	SH	Call	DFND	1	0	339	0
ANADARKO PETROLEUM CORP	COM	032511107	7,101	90,971	SH		DFND	1	0	90,971	0
ANADARKO PETROLEUM CORP	COM	032511907	4,527	580	SH	Call	DFND	1	0	580	0
ANADARKO PETROLEUM CORP	COM	032511957	11,889	1,523	SH	Put	DFND	1	0	1,523	0
ANI PHARMACEUTICALS INC	COM	00182C903	2,482	400	SH	Call	DFND	1	0	400	0
ANTERO MIDSTREAM PARTNERS LP	UNIT	03673L903	2,326	812	SH	Call	DFND	1	0	812	0
ANTERO RESOURCES CORP	COM	03674X106	246	8,580	SH		DFND	1	0	8,580	0
APPLIED DNA SCIENCES EQUITY WARRANTS	*W	03815U110	306	205,347	SH		DFND	1	0	205,347	0
APPLIED DNA SCIENCES INC	COM	03815U201	289	93,368	SH		DFND	1	0	93,368	0
APPLIED GENETIC TECHNOLOGIES CORP	COM	03820J100	2,645	172,427	SH		DFND	1	0	172,427	0
APRICUS BIOSCIENCES INC	COM	03832V959	122	712	SH	Put	DFND	1	0	712	0
APRICUS BIOSCIENCES INC	COM	03832V109	64	37,160	SH		DFND	1	0	37,160	0
ARDELYX INC	COM	039697107	220	13,757	SH		DFND	1	0	13,757	0
ARIAD PHARMACEUTICALS INC	COM	04033A950	1,322	1,599	SH	Put	DFND	1	0	1,599	0
ARIAD PHARMACEUTICALS INC	COM	04033A100	1,367	165,270	SH		DFND	1	0	165,270	0
ASCENDIS PHARMA ADR	ADR	04351P101	2,813	160,000	SH		DFND	1	0	160,000	0
ATHERSYS INC	COM	04744L956	272	2,244	SH	Put	DFND	1	0	2,244	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G107	3,212	197,800	SH		DFND	1	0	197,800	0
BARCLAYS BANK IPATH SandP 500 VIX	IPATH	06740C519	5,031	450,000	SH		DFND	1	0	450,000	0
BARCLAYS BANK IPATH SandP 500 VIX	IPATH	06742E711	3,182	158,000	SH		DFND	1	0	158,000	0
BELLEROPHON THERAPEUTICS ORD SHS	COM	078771102	283	35,727	SH		DFND	1	0	35,727	0
BELLICUM PHARMACEUTICALS INC	COM	079481107	5,127	241,039	SH		DFND	1	0	241,039	0
BELLICUM PHARMACEUTICALS INC	COM	079481907	342	161	SH	Call	DFND	1	0	161	0
BELLICUM PHARMACEUTICALS INC	COM	079481957	691	325	SH	Put	DFND	1	0	325	0
BIO PATH HOLDINGS INC.	COM	09057N102	16	13,873	SH		DFND	1	0	13,873	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V903	2,571	1,722	SH	Call	DFND	1	0	1,722	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V953	4,955	3,319	SH	Put	DFND	1	0	3,319	0
BIODEL INC	COM	09064M954	19	182	SH	Put	DFND	1	0	182	0
BIODEL INC	COM	09064M204	1,184	1,149,394	SH		DFND	1	0	1,149,394	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J906	365	458	SH	Call	DFND	1	0	458	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J956	628	789	SH	Put	DFND	1	0	789	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J106	765	96,100	SH		DFND	1	0	96,100	0
BIOGEN IDEC INC	COM	09062X903	175,512	4,345	SH	Call	DFND	1	0	4,345	0
BIOGEN IDEC INC	COM	09062X953	44,837	1,110	SH	Put	DFND	1	0	1,110	0
BIOLASE INC	COM	090911108	522	300,000	SH		DFND	1	0	300,000	0
BIOMARIN PHARMACEUTICAL 0.75%	NOTE	09061GAE1	7,768	5,000,000	SH		DFND	1	0	5,000,000	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G901	51,922	3,796	SH	Call	DFND	1	0	3,796	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G951	22,596	1,652	SH	Put	DFND	1	0	1,652	0
BLUEBIRD BIO INC	COM	09609G900	24,060	1,429	SH	Call	DFND	1	0	1,429	0
BLUEBIRD BIO INC	COM	09609G950	14,968	889	SH	Put	DFND	1	0	889	0
BLUEPRINT MEDICINES ORD SHS	COM	09627Y109	7,995	301,804	SH		DFND	1	0	301,804	0
BRAINSTORM CELL THERAPEUTICS	COM	10501E201	2,685	743,647	SH		DFND	1	0	743,647	0
BRISTOL MYERS SQUIBB CO	COM	110122908	20,448	3,073	SH	Call	DFND	1	0	3,073	0
CALADRIUS BIOSCIENCES INC	COM	128058104	889	475,363	SH		DFND	1	0	475,363	0
CAPRICOR THERAPEUTICS INC	COM	14070B101	1,305	258,400	SH		DFND	1	0	258,400	0
CARDICA INC	COM	14141R101	2,063	4,134,400	SH		DFND	1	0	4,134,400	0
CASI PHARMACEUTICALS INC.	COM	14757U109	0	243,201	SH		DFND	1	0	243,201	0
CASTLIGHT HEALTH INC	COM	14862Q900	1,749	2,149	SH	Call	DFND	1	0	2,149	0
CEL SCI EQUITY WARRANTS	*W	150837177	369	1,845,841	SH		DFND	1	0	1,845,841	0
CELLDEX THERAPEUTICS INC	COM	15117B903	10,292	4,081	SH	Call	DFND	1	0	4,081	0
CELLDEX THERAPEUTICS INC	COM	15117B953	4,444	1,762	SH	Put	DFND	1	0	1,762	0
CELLECTAR BIOSCIENCES INC	COM	15117F203	1,643	570,380	SH		DFND	1	0	570,380	0
CELLECTAR BIOSCIENCES WARRANTS	*W	15117F112	492	656,513	SH		DFND	1	0	656,513	0
CELSION CORPORATION	COM	15117N954	128	546	SH	Put	DFND	1	0	546	0
CELSION CORPORATION	COM	15117N404	1,488	633,396	SH		DFND	1	0	633,396	0
CEMPRA INC	COM	15130J909	1,721	501	SH	Call	DFND	1	0	501	0
CEMPRA INC	COM	15130J109	2,733	79,553	SH		DFND	1	0	79,553	0
CESCA THERAPEUTICS INC.	COM	157131103	3,151	3,706,516	SH		DFND	1	0	3,706,516	0
CHINA BIOLOGIC PRODUCTS INC	COM	16938C106	576	5,000	SH		DFND	1	0	5,000	0
CHINA MOBILE LIMITED ADR	ADR	16941M909	3,583	559	SH	Call	DFND	1	0	559	0
CIDARA THERAPEUTICS INC	COM	171757107	4,136	294,982	SH		DFND	1	0	294,982	0
COHERUS BIOSCIENCES INC.	COM	19249H103	867	30,000	SH		DFND	1	0	30,000	0
COLLABRX INC	COM	19422J108	610	883,324	SH		DFND	1	0	883,324	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668908	1,606	255	SH	Call	DFND	1	0	255	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668958	4,452	707	SH	Put	DFND	1	0	707	0
CONATUS PHARMACEUTICALS INC	COM	20600T108	1,923	373,493	SH		DFND	1	0	373,493	0
CTI BIOPHARMA CORP	COM	12648L906	1,121	5,747	SH	Call	DFND	1	0	5,747	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L306	1,680	2,099,851	SH		DFND	1	0	2,099,851	0
CYMABAY THERAPEUTICS INC	COM	23257D103	269	100,000	SH		DFND	1	0	100,000	0
CYNAPSUS THERAPEUTICS INC	COM	23257Y859	314	19,303	SH		DFND	1	0	19,303	0
CYTOKINETICS INC	COM	23282W955	768	1,143	SH	Put	DFND	1	0	1,143	0
CYTORI THERAPEUTICS INC	COM	23283K105	2,988	5,364,100	SH		DFND	1	0	5,364,100	0
CYTRX CORP	COM	232828959	64	173	SH	Put	DFND	1	0	173	0
DERMIRA ORD SHS	COM	24983L104	4,861	276,994	SH		DFND	1	0	276,994	0
DYAX CORP	COM	26746E903	326	123	SH	Call	DFND	1	0	123	0
DYAX CORP	COM	26746E953	200	75	SH	Put	DFND	1	0	75	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	10,619	4,533	SH	Call	DFND	1	0	4,533	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	2,567	1,096	SH	Put	DFND	1	0	1,096	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	1,640	70,000	SH		DFND	1	0	70,000	0
EDAP TMS SA	ADR	268311957	670	2,061	SH	Put	DFND	1	0	2,061	0
EDWARDS LIFESCIENCES CORP.	COM	28176E958	16,622	1,167	SH	Put	DFND	1	0	1,167	0
EDWARDS LIFESCIENCES CORP.	COM	28176E108	2,537	17,815	SH		DFND	1	0	17,815	0
ELI LILLY & CO	COM	532457908	222,676	26,671	SH	Call	DFND	1	0	26,671	0
ELI LILLY & CO	COM	532457958	20,271	2,428	SH	Put	DFND	1	0	2,428	0
ENDO INTERNATIONAL PLC	SHS	G30401906	4,787	601	SH	Call	DFND	1	0	601	0
ENDO INTERNATIONAL PLC	SHS	G30401956	1,784	224	SH	Put	DFND	1	0	224	0
ENDO INTERNATIONAL PLC	SHS	G30401106	2,976	37,358	SH		DFND	1	0	37,358	0
ENTEROMEDICS INC	COM	29365M208	1,023	1,650,232	SH		DFND	1	0	1,650,232	0
ESPERION THERAPEUTICS INC	COM	29664W955	3,262	399	SH	Put	DFND	1	0	399	0
EXACT SCIENCES CORP	COM	30063P905	8,943	3,007	SH	Call	DFND	1	0	3,007	0
EXACT SCIENCES CORP	COM	30063P955	10,382	3,491	SH	Put	DFND	1	0	3,491	0
EXELIXIS INC	COM	30161Q904	856	2,276	SH	Call	DFND	1	0	2,276	0
EXELIXIS INC	COM	30161Q954	381	1,014	SH	Put	DFND	1	0	1,014	0
EXELIXIS INC 4.25%	NOTE	30161QAC8	6,197	6,900,000	SH		DFND	1	0	6,900,000	0
EXXON MOBIL	COM	30231G952	24,403	2,933	SH	Put	DFND	1	0	2,933	0
EXXON MOBIL	COM	30231G102	14,835	178,310	SH		DFND	1	0	178,310	0
FEI CO	COM	30241L909	2,820	340	SH	Call	DFND	1	0	340	0
FIBROGEN INC	COM	31572Q808	2,305	98,100	SH		DFND	1	0	98,100	0
FLUIDIGM CORP	COM	34385P908	1,077	445	SH	Call	DFND	1	0	445	0
FLUIDIGM CORP	COM	34385P108	4,002	165,385	SH		DFND	1	0	165,385	0
FOAMIX PHARMACEUTICALS	SHS	M46135105	1,804	176,000	SH		DFND	1	0	176,000	0
FORWARD PHARMA A/S	ADR	34986J105	1,334	35,050	SH		DFND	1	0	35,050	0
GALENA BIOPHARMA INC	COM	363256958	1,161	6,832	SH	Put	DFND	1	0	6,832	0
GENOCEA BIOSCIENCES INC	COM	372427104	2,315	168,580	SH		DFND	1	0	168,580	0
GEVO INC	COM	374396208	572	175,000	SH		DFND	1	0	175,000	0
GILEAD SCIENCES INC	COM	375558903	150,764	12,877	SH	Call	DFND	1	0	12,877	0
GILEAD SCIENCES INC	COM	375558953	34,363	2,935	SH	Put	DFND	1	0	2,935	0
GREAT BASIN SCIENTIFIC INC	COM	39013L106	153	51,771	SH		DFND	1	0	51,771	0
GREAT BASIN SCIENTIFIC UNITS	UNIT	39013L205	15,283	856,163	SH		DFND	1	0	856,163	0
GW PHARMACEUTICALS PLC	ADS	36197T903	1,843	150	SH	Call	DFND	1	0	150	0
GW PHARMACEUTICALS PLC	ADS	36197T953	25,330	2,062	SH	Put	DFND	1	0	2,062	0
GW PHARMACEUTICALS PLC	ADS	36197T103	2,261	18,405	SH		DFND	1	0	18,405	0
HALOZYME THERAPEUTICS INC	COM	40637H909	9,064	4,014	SH	Call	DFND	1	0	4,014	0
HALOZYME THERAPEUTICS INC	COM	40637H959	1,897	840	SH	Put	DFND	1	0	840	0
HCA HOLDINGS INC	COM	40412C901	4,754	524	SH	Call	DFND	1	0	524	0
HCA HOLDINGS INC	COM	40412C951	2,939	324	SH	Put	DFND	1	0	324	0
HEALTH CARE SELECT SECTOR SPDR	TR	81369Y959	44,637	5,998	SH	Put	DFND	1	0	5,998	0
HEARTWARE INTERNATIONAL INC	COM	422368900	363	50	SH	Call	DFND	1	0	50	0
HEAT BIOLOGICS INC	COM	42237K102	258	43,034	SH		DFND	1	0	43,034	0
HERON THERAPEUTICS INC	COM	427746902	10,236	3,285	SH	Call	DFND	1	0	3,285	0
HISTOGENICS CORP	COM	43358V109	178	27,505	SH		DFND	1	0	27,505	0
HUMANA INC	COM	444859902	9,564	500	SH	Call	DFND	1	0	500	0
IDERA PHARMACEUTICALS INC	COM	45168K906	714	1,924	SH	Call	DFND	1	0	1,924	0
IDERA PHARMACEUTICALS INC	COM	45168K956	95	257	SH	Put	DFND	1	0	257	0
IDERA PHARMACEUTICALS INC	COM	45168K306	86	23,297	SH		DFND	1	0	23,297	0
IGNYTA INC.	COM	451731103	2,476	164,100	SH		DFND	1	0	164,100	0
IMMUNOCELLULAR THERAPEUTICS	COM	452536105	2,771	5,871,816	SH		DFND	1	0	5,871,816	0
INFINITY PHARMACEUTICALS INC	COM	45665G903	2,158	1,971	SH	Call	DFND	1	0	1,971	0
INFINITY PHARMACEUTICALS INC	COM	45665G953	329	300	SH	Put	DFND	1	0	300	0
INFRAREIT INC	COM	45685L900	1,957	690	SH	Call	DFND	1	0	690	0
INOVIO PHARMACEUTICALS	COM	45773H201	7,393	906,000	SH		DFND	1	0	906,000	0
INSMED INC	COM	457669907	796	326	SH	Call	DFND	1	0	326	0
INSMED INC	COM	457669957	974	399	SH	Put	DFND	1	0	399	0
INSPIREMD ORD SHS	COM	45779A309	260	927,876	SH		DFND	1	0	927,876	0
INTELLIPHARMACEUTICS INTERNATIONAL INC	COM	458173951	243	826	SH	Put	DFND	1	0	826	0
INTEROIL CORP	COM	460951956	20,203	3,356	SH	Put	DFND	1	0	3,356	0
INTEROIL CORP	COM	460951106	9,219	153,144	SH		DFND	1	0	153,144	0
INTRA-CELLULAR THERAPIES INC	COM	46116X901	3,645	1,141	SH	Call	DFND	1	0	1,141	0
INTREXON CORP	COM	46122T902	1,581	324	SH	Call	DFND	1	0	324	0
INTREXON CORP	COM	46122T952	439	90	SH	Put	DFND	1	0	90	0
IPATH S&P 500 VIX MID-TERM FUTURES ETN	ETN	06740C909	4,774	4,270	SH	Call	DFND	1	0	4,270	0
IPATH S&P 500 VIX SHORT-TERM FUTURES ETN	ETN	06742E901	4,028	2,000	SH	Call	DFND	1	0	2,000	0
ISHARES 20+ YEAR TREASURY BOND ETF	ETF	464287432	28,895	246,000	SH		DFND	1	0	246,000	0
ISHARES 20+ YEAR TREASURY BOND ETF	ETF	464287952	41,111	3,500	SH	Put	DFND	1	0	3,500	0
ISHARES RUSSELL 2000 ETF	ETF	464287955	182,756	14,637	SH	Put	DFND	1	0	14,637	0
ISIS PHARMACEUTICALS INC	COM	464330909	6,670	1,159	SH	Call	DFND	1	0	1,159	0
JUNO THERAPEUTICS	COM	48205A959	693	130	SH	Put	DFND	1	0	130	0
JUNO THERAPEUTICS	COM	48205A109	604	11,333	SH		DFND	1	0	11,333	0
KERYX BIOPHARMACEUTICALS	COM	492515951	188	188	SH	Put	DFND	1	0	188	0
KITE PHARMA INC	COM	49803L959	622	102	SH	Put	DFND	1	0	102	0
KITE PHARMA INC	COM	49803L109	224	3,672	SH		DFND	1	0	3,672	0
LEXICON PHARMACEUTICALS INC	COM	528872302	2,566	318,775	SH		DFND	1	0	318,775	0
LION BIOTECHNOLOGIES INC	COM	53619R102	3,918	427,244	SH		DFND	1	0	427,244	0
LIPOCINE INC	COM	53630X104	6,221	725,000	SH		DFND	1	0	725,000	0
LPATH INC	COM	548910306	49	178,600	SH		DFND	1	0	178,600	0
LPATH ORD SHS	COM	548910306	25	90,058	SH		DFND	1	0	90,058	0
MALLINCKRODT PLC	SHS	G5785G907	1,495	127	SH	Call	DFND	1	0	127	0
MALLINCKRODT PLC	SHS	G5785G957	11,537	980	SH	Put	DFND	1	0	980	0
MALLINCKRODT PLC	SHS	G5785G107	4,772	40,539	SH		DFND	1	0	40,539	0
MANNKIND CORP	COM	56400P901	9,363	16,456	SH	Call	DFND	1	0	16,456	0
MANNKIND CORP	COM	56400P951	12,202	21,444	SH	Put	DFND	1	0	21,444	0
MANNKIND CORP	COM	56400P201	838	147,304	SH		DFND	1	0	147,304	0
MEDGENICS EQUITY WARRANTS	*W	58436Q112	1,440	1,439,840	SH		DFND	1	0	1,439,840	0
MEDICINES CO	COM	584688905	12,689	4,435	SH	Call	DFND	1	0	4,435	0
MEDICINES CO	COM	584688955	2,297	803	SH	Put	DFND	1	0	803	0
MEDICINES CO 1.375%	DBCV	584688AC9	13,414	11,213,000	SH		DFND	1	0	11,213,000	0
MEI PHARMA ORD SHS	COM	55279B202	505	295,491	SH		DFND	1	0	295,491	0
MELA SCIENCES INC.	COM	55277R308	523	454,352	SH		DFND	1	0	454,352	0
MERCK & CO INC	COM	58933Y955	29,797	5,234	SH	Put	DFND	1	0	5,234	0
MERCK & CO INC	COM	58933Y105	17,892	314,285	SH		DFND	1	0	314,285	0
MERCK & CO INC	COM	58933Y905	56,930	10,000	SH	Call	DFND	1	0	10,000	0
MOBILEYE N.V. REG.	SHS	N51488907	13,537	2,546	SH	Call	DFND	1	0	2,546	0
MOBILEYE N.V. REG.	SHS	N51488957	21,917	4,122	SH	Put	DFND	1	0	4,122	0
MOBILEYE N.V. REG.	SHS	N51488117	3,926	73,832	SH		DFND	1	0	73,832	0
MYLAN N.V.	SHS	N59465909	18,845	2,777	SH	Call	DFND	1	0	2,777	0
MYLAN N.V.	SHS	N59465959	22,095	3,256	SH	Put	DFND	1	0	3,256	0
NANOSPHERE INC	COM	63009F204	548	169,031	SH		DFND	1	0	169,031	0
NEUROCRINE BIOSCIENCES INC	COM	64125C909	6,605	1,383	SH	Call	DFND	1	0	1,383	0
NEUROCRINE BIOSCIENCES INC	COM	64125C959	1,151	241	SH	Put	DFND	1	0	241	0
NEUROMETRIX EQUITY WARRANTS	*W	641255138	2,437	12,182,926	SH		DFND	1	0	12,182,926	0
NEUROMETRIX INC.	COM	641255302	727	798,939	SH		DFND	1	0	798,939	0
NEWLINK GENETICS CORP	COM	651511907	13,826	3,123	SH	Call	DFND	1	0	3,123	0
NEWLINK GENETICS CORP	COM	651511957	6,185	1,397	SH	Put	DFND	1	0	1,397	0
NIVALIS THERAPEUTICS	COM	65481J109	6,515	430,041	SH		DFND	1	0	430,041	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P950	6,814	6,862	SH	Put	DFND	1	0	6,862	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P600	3,261	328,400	SH		DFND	1	0	328,400	0
NOVAVAX INC	COM	670002904	5,236	4,700	SH	Call	DFND	1	0	4,700	0
NOVAVAX INC	COM	670002954	7,685	6,899	SH	Put	DFND	1	0	6,899	0
NOVO-NORDISK ADR	ADR	670100955	460	84	SH	Put	DFND	1	0	84	0
NUVASIVE INC	COM	670704905	1,611	340	SH	Call	DFND	1	0	340	0
NXSTAGE MEDICAL INC	COM	67072V103	722	50,542	SH		DFND	1	0	50,542	0
OCATA THERAPEUTICS ORD SHS	COM	67457L100	1,858	352,544	SH		DFND	1	0	352,544	0
OCERA THERAPEUTICS ORD SHS	COM	67552A108	1,442	379,574	SH		DFND	1	0	379,574	0
OCULAR THERAPEUTIX ORD SHS	COM	67576A100	2,103	100,000	SH		DFND	1	0	100,000	0
OHR PHARMACEUTICAL ORD SHS	COM	67778H200	226	89,982	SH		DFND	1	0	89,982	0
OMEROS CORP	COM	682143902	894	497	SH	Call	DFND	1	0	497	0
ONCOSEC MEDICAL INC	COM	68234L207	4,860	767,733	SH		DFND	1	0	767,733	0
OPEXA THERAPEUTICS EQUITY WARRANTS	*W	68372T129	93	545,505	SH		DFND	1	0	545,505	0
OPKO HEALTH INC	COM	68375N903	7,236	4,500	SH	Call	DFND	1	0	4,500	0
OPKO HEALTH INC	COM	68375N953	12,054	7,496	SH	Put	DFND	1	0	7,496	0
OPKO HEALTH INC	COM	68375N103	3,588	223,126	SH		DFND	1	0	223,126	0
ORAMED PHARMACEUTICALS	COM	68403P203	1,204	212,017	SH		DFND	1	0	212,017	0
ORGANOVO HOLDINGS INC.	COM	68620A104	1,092	289,610	SH		DFND	1	0	289,610	0
ORIENT PAPER INC	COM	68619F955	17	103	SH	Put	DFND	1	0	103	0
OVASCIENCE INC	COM	69014Q901	6,365	2,200	SH	Call	DFND	1	0	2,200	0
OVASCIENCE INC	COM	69014Q951	579	200	SH	Put	DFND	1	0	200	0
OVASCIENCE INC	COM	69014Q101	10,270	355,000	SH		DFND	1	0	355,000	0
OXIGENE INC	COM	691828404	362	258,435	SH		DFND	1	0	258,435	0
PARATEK PHARMACEUTICALS INC	COM	699374302	1,433	55,613	SH		DFND	1	0	55,613	0
PEREGRINE PHARMACEUTICALS INC	COM	713661304	1,533	67,578	SH		DFND	1	0	67,578	0
PERRIGO CO	SHS	G97822903	17,097	925	SH	Call	DFND	1	0	925	0
PIONEER NATURAL RESOURCES CO	COM	723787957	17,142	1,236	SH	Put	DFND	1	0	1,236	0
PIONEER NATURAL RESOURCES CO	COM	723787107	10,578	76,273	SH		DFND	1	0	76,273	0
PLURISTEM THERAPEUTICS INC	COM	72940R952	996	3,953	SH	Put	DFND	1	0	3,953	0
PLURISTEM THERAPEUTICS INC	COM	72940R102	8,219	3,261,642	SH		DFND	1	0	3,261,642	0
PROGENICS PHARMACEUTICALS INC	COM	743187906	454	609	SH	Call	DFND	1	0	609	0
PROGENICS PHARMACEUTICALS INC	COM	743187956	2,513	3,369	SH	Put	DFND	1	0	3,369	0
PROGENICS PHARMACEUTICALS INC	COM	743187106	1,848	247,706	SH		DFND	1	0	247,706	0
PROQR THERAPEUTICS ORD SHS	SHS	N71542109	1,384	83,000	SH		DFND	1	0	83,000	0
PROVECTUS BIOPHARMACEUTICALS EQUITY WARRANTS	*W	74373P116	164	749,337	SH		DFND	1	0	749,337	0
PROVECTUS BIOPHARMACEUTICALS INC.	COM	74373P108	1,769	3,275,929	SH		DFND	1	0	3,275,929	0
PTC THERAPEUTICS INC	COM	69366J900	2,941	611	SH	Call	DFND	1	0	611	0
PTC THERAPEUTICS INC	COM	69366J950	573	119	SH	Put	DFND	1	0	119	0
PUMA BIOTECHNOLOGY INC	COM	74587V907	2,253	193	SH	Call	DFND	1	0	193	0
PUMA BIOTECHNOLOGY INC	COM	74587V957	3,304	283	SH	Put	DFND	1	0	283	0
QUEST RESOURCE HOLDING CORP	COM	74836W104	3,314	3,068,192	SH		DFND	1	0	3,068,192	0
RAPTOR PHARMACEUTICAL CORP	COM	75382F906	13,534	8,571	SH	Call	DFND	1	0	8,571	0
RAPTOR PHARMACEUTICAL CORP	COM	75382F956	1,626	1,030	SH	Put	DFND	1	0	1,030	0
RARE ELEMENT RESOURCES LTD	COM	75381M102	1,770	4,212,092	SH		DFND	1	0	4,212,092	0
RECEPTOS INC	COM	756207906	9,598	505	SH	Call	DFND	1	0	505	0
RECEPTOS INC	COM	756207956	7,203	379	SH	Put	DFND	1	0	379	0
REGENERON PHARMACEUTICALS INC	COM	75886F907	15,508	304	SH	Call	DFND	1	0	304	0
REGENERON PHARMACEUTICALS INC	COM	75886F957	46,269	907	SH	Put	DFND	1	0	907	0
REGULUS THERAPEUTIC INC	COM	75915K901	12,945	11,811	SH	Call	DFND	1	0	11,811	0
REGULUS THERAPEUTIC INC	COM	75915K101	3,778	344,667	SH		DFND	1	0	344,667	0
REPROS THERAPEUTICS INC	COM	76028H909	1,628	2,277	SH	Call	DFND	1	0	2,277	0
REPROS THERAPEUTICS INC	COM	76028H959	1,937	2,709	SH	Put	DFND	1	0	2,709	0
REPROS THERAPEUTICS INC	COM	76028H209	298	41,643	SH		DFND	1	0	41,643	0
REVANCE THERAPEUTICS INC	COM	761330909	1,964	614	SH	Call	DFND	1	0	614	0
RICEBRAN TECHNOLOGIES ORD SHS	COM	762831204	2,876	845,857	SH		DFND	1	0	845,857	0
ROCKWELL MEDICAL INC	COM	774374952	664	412	SH	Put	DFND	1	0	412	0
ROCKWELL MEDICAL INC	COM	774374102	286	17,759	SH		DFND	1	0	17,759	0
SAGE THERAPEUTICS INC	COM	78667J108	1,831	25,080	SH		DFND	1	0	25,080	0
SANGAMO BIOSCIENCES INC	COM	800677906	10,115	9,121	SH	Call	DFND	1	0	9,121	0
SANGAMO BIOSCIENCES INC	COM	800677106	3,586	323,390	SH		DFND	1	0	323,390	0
SAREPTA THERAPEUTICS INC	COM	803607900	20,458	6,723	SH	Call	DFND	1	0	6,723	0
SAREPTA THERAPEUTICS INC	COM	803607950	5,103	1,677	SH	Put	DFND	1	0	1,677	0
SAREPTA THERAPEUTICS INC	COM	803607100	2,179	71,600	SH		DFND	1	0	71,600	0
SKYSTAR BIO PHARMACEUTICAL CO.	COM	830884300	415	156,026	SH		DFND	1	0	156,026	0
SPARK THERAPEUTICS INC	COM	84652J903	5,412	898	SH	Call	DFND	1	0	898	0
SPARK THERAPEUTICS INC	COM	84652J953	4,574	759	SH	Put	DFND	1	0	759	0
SPDR S&P 500 ETF TRUST	UNIT	78462F953	205,852	10,000	SH	Put	DFND	1	0	10,000	0
SPDR S&P BIOTECH ETF	ETF	78464A950	16,749	664	SH	Put	DFND	1	0	664	0
STEMCELLS INC	COM	85857R204	1,144	2,117,234	SH		DFND	1	0	2,117,234	0
SUNESIS PHARMACEUTICALS INC	COM	867328951	1,534	5,097	SH	Put	DFND	1	0	5,097	0
SUNESIS PHARMACEUTICALS INC	COM	867328601	738	245,112	SH		DFND	1	0	245,112	0
SUPERCONDUCTOR TECHNOLOGIES INC.	COM	867931404	1,777	1,692,586	SH		DFND	1	0	1,692,586	0
SYNERGY PHARMACEUTICALS EQUITY WARRANTS	*W	871639118	1,112	296,606	SH		DFND	1	0	296,606	0
SYNERGY PHARMACEUTICALS INC	COM	871639958	2,603	3,136	SH	Put	DFND	1	0	3,136	0
T2 BIOSYSTEMS INC	COM	89853L104	1,578	97,208	SH		DFND	1	0	97,208	0
TEKMIRA PHARMACEUTICALS CORP	COM	87911B909	779	657	SH	Call	DFND	1	0	657	0
TEKMIRA PHARMACEUTICALS CORP	COM	87911B209	3,621	305,351	SH		DFND	1	0	305,351	0
TENAX THERAPEUTICS INC	COM	88032L100	9,913	2,686,247	SH		DFND	1	0	2,686,247	0
TENAX THERAPEUTICS INC	COM	88032L900	12,168	2,151	SH	Call	DFND	1	0	2,151	0
TENET HEALTHCARE CORP	COM	88033G957	35,585	6,148	SH	Put	DFND	1	0	6,148	0
TESARO INC	COM	881569907	523	89	SH	Call	DFND	1	0	89	0
TESARO INC	COM	881569957	1,176	200	SH	Put	DFND	1	0	200	0
TEVA PHARMACEUTICAL INDUSTRIES LTD	ADR	881624909	319	54	SH	Call	DFND	1	0	54	0
TEVA PHARMACEUTICAL INDUSTRIES LTD	ADR	881624959	30,791	5,210	SH	Put	DFND	1	0	5,210	0
TEVA PHARMACEUTICAL INDUSTRIES LTD	ADR	881624209	247	4,173	SH		DFND	1	0	4,173	0
THERAPEUTICSMD INC	COM	88338N907	5,075	6,457	SH	Call	DFND	1	0	6,457	0
THORATEC CORP	COM	885175907	11,080	2,486	SH	Call	DFND	1	0	2,486	0
THORATEC CORP	COM	885175957	267	60	SH	Put	DFND	1	0	60	0
TOKAI PHARMACEUTICALS INC.	COM	88907J107	1,703	128,041	SH		DFND	1	0	128,041	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260201	260	29,026	SH		DFND	1	0	29,026	0
TRANSENTERIX INC	COM	89366M201	5,057	1,685,800	SH		DFND	1	0	1,685,800	0
TRANSITION THERAPEUTICS INC	COM	893716209	636	302,837	SH		DFND	1	0	302,837	0
TRUPANION INC	COM	898202106	1,327	161,012	SH		DFND	1	0	161,012	0
UNIQURE B.V.	SHS	N90064901	1,031	382	SH	Call	DFND	1	0	382	0
UNITED THERAPEUTICS CORP	COM	91307C902	9,324	536	SH	Call	DFND	1	0	536	0
VALEANT PHARMACEUTICALS INTERNATIONAL INC	COM	91911K952	1,888	85	SH	Put	DFND	1	0	85	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	1,667	135	SH	Call	DFND	1	0	135	0
VIGGLE ORD SHS	COM	92672V204	4,053	1,976,911	SH		DFND	1	0	1,976,911	0
VITAL THERAPIES INC	COM	92847R954	306	145	SH	Put	DFND	1	0	145	0
XENOPORT INC	COM	98411C900	266	434	SH	Call	DFND	1	0	434	0
XOMA CORP	COM	98419J907	2,350	6,056	SH	Call	DFND	1	0	6,056	0
XOMA CORP	COM	98419J957	458	1,181	SH	Put	DFND	1	0	1,181	0
XTL BIOPHARMACEUTICALS LTD	ADR	98386D208	2,210	1,150,981	SH		DFND	1	0	1,150,981	0
ZAFGEN INC	COM	98885E903	381	110	SH	Call	DFND	1	0	110	0
ZAFGEN INC	COM	98885E953	1,025	296	SH	Put	DFND	1	0	296	0
ZOGENIX INC	COM	98978L905	4,281	25,485	SH	Call	DFND	1	0	25,485	0
ZOGENIX INC	COM	98978L105	10,018	5,963,095	SH		DFND	1	0	5,963,095	0
ZOSANO PHARMA ORD SHS	COM	98979H103	1,256	173,225	SH		DFND	1	0	173,225	0
ZS PHARMA INC	COM	98979G955	3,353	640	SH	Put	DFND	1	0	640	0
ZS PHARMA INC	COM	98979G105	778	14,848	SH		DFND	1	0	14,848	0