Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y909	40,568	7,456	SH	Call	DFND	1	0	7,456	0
ABBVIE INC	COM	00287Y109	1,280	23,516	SH		DFND	1	0	23,516	0
ABBVIE INC	COM	00287Y959	12,362	2,272	SH	Put	DFND	1	0	2,272	0
ABEONA THERAPEUTICS INC	COM	00289Y107	1,380	340,702	SH		DFND	1	0	340,702	0
ACADIA PHARMACEUTICALS INC	COM	004225908	4,755	1,438	SH	Call	DFND	1	0	1,438	0
ACADIA PHARMACEUTICALS INC	COM	004225958	7,471	2,259	SH	Put	DFND	1	0	2,259	0
ACELRX PHARMACEUTICALS INC	COM	00444T900	52	172	SH	Call	DFND	1	0	172	0
ACELRX PHARMACEUTICALS INC	COM	00444T950	57	186	SH	Put	DFND	1	0	186	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	301	98,602	SH		DFND	1	0	98,602	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	4,779	6,916	SH	Call	DFND	1	0	6,916	0
ACORDA THERAPEUTICS INC NOTE 1.75%	NOTE	00484MAA4	8,664	9,600,000	SH		DFND	1	0	9,600,000	0
ACTINIUM PHARMACEUTICALS INC	COM	00507W107	121	68,427	SH		DFND	1	0	68,427	0
ACURA PHARMACEUTICALS INC	COM	00509L802	1,747	743,603	SH		DFND	1	0	743,603	0
ADAMAS PHARMACEUTICALS INC	COM	00548A106	1,284	76,717	SH		DFND	1	0	76,717	0
ADAPTIMMUNE THERAPEUTICS PLC	ADR	00653A107	120	10,004	SH		DFND	1	0	10,004	0
ADVAXIS INC	COM	007624958	872	852	SH	Put	DFND	1	0	852	0
ADVAXIS INC	COM	007624208	877	85,700	SH		DFND	1	0	85,700	0
ADVAXIS INC	COM	007624908	1,494	1,460	SH	Call	DFND	1	0	1,460	0
AERIE PHARMACEUTICALS INC	COM	00771V908	381	215	SH	Call	DFND	1	0	215	0
AFFIMED N V	COM	N01045108	350	56,773	SH		DFND	1	0	56,773	0
AGIOS PHARMACEUTICALS INC	COM	00847X904	1,645	233	SH	Call	DFND	1	0	233	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	7,731	109,521	SH		DFND	1	0	109,521	0
AGIOS PHARMACEUTICALS INC	COM	00847X954	8,280	1,173	SH	Put	DFND	1	0	1,173	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	787	134,997	SH		DFND	1	0	134,997	0
ALEXION PHARMACEUTICALS INC	COM	015351909	2,377	152	SH	Call	DFND	1	0	152	0
ALEXION PHARMACEUTICALS INC	COM	015351109	7,725	49,397	SH		DFND	1	0	49,397	0
ALEXION PHARMACEUTICALS INC	COM	015351959	15,248	975	SH	Put	DFND	1	0	975	0
ALKERMES PLC	SHS	G01767105	260	537	SH	Call	DFND	1	0	537	0
ALLIQUA BIOMEDICAL INC	COM	019621200	1,047	330,128	SH		DFND	1	0	330,128	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	547	6,809	SH		DFND	1	0	6,809	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q957	6,340	789	SH	Put	DFND	1	0	789	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q907	13,468	1,676	SH	Call	DFND	1	0	1,676	0
AMARIN CORPORATION PLC	ADR	023111906	216	1,118	SH	Put	DFND	1	0	1,118	0
AMARIN CORPORATION PLC	ADR	023111206	1,579	8,183	SH	Call	DFND	1	0	8,183	0
AMICUS THERAPEUTICS INC	COM	03152W909	1,021	730	SH	Call	DFND	1	0	730	0
AMICUS THERAPEUTICS INC	COM	03152W959	3,248	2,322	SH	Put	DFND	1	0	2,322	0
ANACOR PHARMACEUTICALS INC	COM	032420101	942	8,000	SH		DFND	1	0	8,000	0
ANACOR PHARMACEUTICALS INC	COM	032420901	1,177	100	SH	Call	DFND	1	0	100	0
ANACOR PHARMACEUTICALS INC	COM	032420951	1,177	100	SH	Put	DFND	1	0	100	0
ANADARKO PETROLEUM CORP	COM	032511957	6,178	1,023	SH	Put	DFND	1	0	1,023	0
ANADARKO PETROLEUM CORP	COM	032511107	6,178	102,300	SH		DFND	1	0	102,300	0
ANTARES PHARMA INC	COM	036642906	466	2,742	SH	Call	DFND	1	0	2,742	0
ANTARES PHARMA INC	COM	036642106	1,228	722,567	SH		DFND	1	0	722,567	0
ANTHERA PHARMACEUTICALS INC	COM	03674U901	1,218	2,000	SH	Call	DFND	1	0	2,000	0
AOXING PHARMACEUTICAL INC	COM	03740A106	3,158	2,134,054	SH		DFND	1	0	2,134,054	0
APPLE INC	COM	037833900	12,243	1,110	SH	Call	DFND	1	0	1,110	0
APPLIED DNA SCIENCES EQUITY WARRANTS	*W	03815U110	196	63,310	SH		DFND	1	0	63,310	0
APPLIED GENETIC TECHNOLOGIES CORP	COM	03820J100	1,629	124,000	SH		DFND	1	0	124,000	0
APRICUS BIOSCIENCES INC SHS	COM	03832V109	18	12,176	SH		DFND	1	0	12,176	0
APRICUS BIOSCIENCES INC SHS	COM	03832V959	88	605	SH	Put	DFND	1	0	605	0
AQUINOX PHARMACEUTICALS INC	COM	03842B101	844	60,000	SH		DFND	1	0	60,000	0
ARBUTUS BIOPHARMA CORP	COM	03879J900	479	787	SH	Call	DFND	1	0	787	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	4,415	725,007	SH		DFND	1	0	725,007	0
ARIAD PHARMACEUTICALS INC	COM	04033A950	987	1,690	SH	Put	DFND	1	0	1,690	0
ARIAD PHARMACEUTICALS INC	COM	04033A100	987	169,000	SH		DFND	1	0	169,000	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G957	247	300	SH	Put	DFND	1	0	300	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G907	437	530	SH	Call	DFND	1	0	530	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G107	4,732	574,260	SH		DFND	1	0	574,260	0
AXOVANT SCIENCES ORD SHS	COM	G0750W104	272	21,053	SH		DFND	1	0	21,053	0
BARCLAYS BANK PLC	ETN	06740C909	1,736	1,334	SH	Call	DFND	1	0	1,334	0
BARCLAYS BANK PLC	ETN	06740C519	5,861	450,500	SH		DFND	1	0	450,500	0
BELLICUM PHARMACEUTICALS INC	COM	079481957	472	325	SH	Put	DFND	1	0	325	0
BELLICUM PHARMACEUTICALS INC	COM	079481907	764	526	SH	Call	DFND	1	0	526	0
BELLICUM PHARMACEUTICALS INC	COM	079481107	1,745	120,094	SH		DFND	1	0	120,094	0
BENITEC BIOPHARMA LTD	ADR	082053307	3,107	505,220	SH		DFND	1	0	505,220	0
BENITEC BIOPHARMA LTD	*W	082053117	143	391,826	SH		DFND	1	0	391,826	0
BIO PATH HOLDINGS INC	COM	09057N102	17	14,873	SH		DFND	1	0	14,873	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	985	86,395	SH		DFND	1	0	86,395	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V953	2,199	1,929	SH	Put	DFND	1	0	1,929	0
BIODEL INC	COM	09064M204	433	983,670	SH		DFND	1	0	983,670	0
BIODEL INC	COM	09064M954	8	182	SH	Put	DFND	1	0	182	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J906	255	458	SH	Call	DFND	1	0	458	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J956	439	789	SH	Put	DFND	1	0	789	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J106	2,050	368,641	SH		DFND	1	0	368,641	0
BIOGEN IDEC INC	COM	09062X103	22,945	78,629	SH		DFND	1	0	78,629	0
BIOGEN IDEC INC	COM	09062X953	41,408	1,419	SH	Put	DFND	1	0	1,419	0
BIOGEN IDEC INC	COM	09062X903	90,169	3,090	SH	Call	DFND	1	0	3,090	0
BIOLASE INC	COM	090911108	255	283,231	SH		DFND	1	0	283,231	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	18,333	174,073	SH		DFND	1	0	174,073	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G901	25,014	2,375	SH	Call	DFND	1	0	2,375	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G951	30,659	2,911	SH	Put	DFND	1	0	2,911	0
BIOMARIN PHARMACEUTICAL INC. NOTE .75%	NOTE	09061GAE1	6,459	5,000,000	SH		DFND	1	0	5,000,000	0
BIOTIE THERAPIES OYJ	ADR	09074D103	524	40,000	SH		DFND	1	0	40,000	0
BLUEBIRD BIO INC	COM	09609G950	3,473	406	SH	Put	DFND	1	0	406	0
BLUEBIRD BIO INC	COM	09609G900	7,605	889	SH	Call	DFND	1	0	889	0
BLUEPRINT MEDICINES INC	COM	09627Y109	6,583	308,504	SH		DFND	1	0	308,504	0
BRAINSTORM CELL THERAPEUTICS	COM	10501E201	1,952	852,348	SH		DFND	1	0	852,348	0
BRISTOL MYERS SQUIBB CO	COM	110122908	18,192	3,073	SH	Call	DFND	1	0	3,073	0
CAPRICOR THERAPEUTICS INC	COM	14070B101	1,014	250,450	SH		DFND	1	0	250,450	0
CARDICA INC	COM	14141R101	1,521	5,281,185	SH		DFND	1	0	5,281,185	0
CASI PHARMACEUTICALS ORD SHS	COM	14757U109	217	202,536	SH		DFND	1	0	202,536	0
CASTLIGHT HEALTH INC	CL B	14862Q900	447	1,065	SH	Call	DFND	1	0	1,065	0
CELLDEX THERAPEUTICS INC	COM	15117B953	251	238	SH	Put	DFND	1	0	238	0
CELLDEX THERAPEUTICS INC	COM	15117B903	4,688	4,448	SH	Call	DFND	1	0	4,448	0
CELLECTAR BIOSCIENCES INC	*W	15117F112	1,079	653,712	SH		DFND	1	0	653,712	0
CELLECTAR BIOSCIENCES INC	COM	15117F203	751	381,172	SH		DFND	1	0	381,172	0
CELSION CORPORATION	COM	15117N954	91	546	SH	Put	DFND	1	0	546	0
CELSION CORPORATION	COM	15117N404	128	76,805	SH		DFND	1	0	76,805	0
CEMPRA INC	COM	15130J109	2,038	73,195	SH		DFND	1	0	73,195	0
CEMPRA INC	COM	15130J959	3,012	1,082	SH	Put	DFND	1	0	1,082	0
CEMPRA INC	COM	15130J909	10,159	3,649	SH	Call	DFND	1	0	3,649	0
CESCA THERAPEUTICS INC.	COM	157131103	1,855	3,500,037	SH		DFND	1	0	3,500,037	0
CHAMPIONS ONCOLOGY ORD SHS	COM	15870P307	893	169,397	SH		DFND	1	0	169,397	0
CHINA BIOLOGIC PRODUCTS INC	COM	16938C106	1,796	20,000	SH		DFND	1	0	20,000	0
CHINA JO-JO DRUGSTORES INC	COM	16949A206	1,118	614,149	SH		DFND	1	0	614,149	0
CHINA MOBILE LIMITED	ADR	16941M909	19	481	SH	Call	DFND	1	0	481	0
CIDARA THERAPEUTICS	COM	171757107	3,893	306,044	SH		DFND	1	0	306,044	0
COLLABRX ORD SHS	COM	19422J108	635	920,375	SH		DFND	1	0	920,375	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668108	1,856	43,397	SH		DFND	1	0	43,397	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668958	2,831	662	SH	Put	DFND	1	0	662	0
CONATUS PHARMACEUTICALS INC	COM	20600T108	278	62,500	SH		DFND	1	0	62,500	0
CTI BIOPHARMA CORP	COM	12648L906	839	5,747	SH	Call	DFND	1	0	5,747	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L306	1,202	2,356,091	SH		DFND	1	0	2,356,091	0
CYMABAY THERAPEUTICS INC	COM	23257D103	569	293,294	SH		DFND	1	0	293,294	0
CYNAPSUS THERAPEUTICS INC	COM	23257Y859	845	52,169	SH		DFND	1	0	52,169	0
CYTOKINETICS INC	COM	23282W955	787	1,176	SH	Put	DFND	1	0	1,176	0
CYTOKINETICS INC	COM	23282W905	2,078	3,106	SH	Call	DFND	1	0	3,106	0
CYTORI THERAPEUTICS INC	COM	23283K105	1,000	2,941,880	SH		DFND	1	0	2,941,880	0
CYTRX ORD SHS	COM	232828509	378	159,584	SH		DFND	1	0	159,584	0
DBV TECHNOLOGIES S A	ADR	23306J101	660	18,541	SH		DFND	1	0	18,541	0
DEPOMED INC	COM	249908104	943	50,000	SH		DFND	1	0	50,000	0
DEPOMED INC	COM	249908904	5,052	2,680	SH	Call	DFND	1	0	2,680	0
DERMIRA INC	COM	24983L104	4,435	190,000	SH		DFND	1	0	190,000	0
DISCOVERY LABORATORIES INC.	COM	254668403	1,411	4,703,551	SH		DFND	1	0	4,703,551	0
DYAX CORP	COM	26746E103	1,520	79,613	SH		DFND	1	0	79,613	0
DYAX CORP	COM	26746E953	1,941	1,017	SH	Put	DFND	1	0	1,017	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	1,458	594	SH	Put	DFND	1	0	594	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	3,312	134,954	SH		DFND	1	0	134,954	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	5,087	2,073	SH	Call	DFND	1	0	2,073	0
EDAP TMS SA	ADR	268311957	819	1,466	SH	Put	DFND	1	0	1,466	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	10,983	77,255	SH		DFND	1	0	77,255	0
EDWARDS LIFESCIENCES CORP	COM	28176E958	34,896	1,682	SH	Put	DFND	1	0	1,682	0
ELEVEN BIOTHERAPEUTICS INC	COM	286221106	413	171,541	SH		DFND	1	0	171,541	0
ELI LILLY & CO	COM	532457958	20,404	2,438	SH	Put	DFND	1	0	2,438	0
ELI LILLY & CO	COM	532457908	182,904	21,855	SH	Call	DFND	1	0	21,855	0
ENDO INTERNATIONAL PLC	SHS	G30401956	1,552	224	SH	Put	DFND	1	0	224	0
ENDO INTERNATIONAL PLC	SHS	G30401106	3,510	50,658	SH		DFND	1	0	50,658	0
ENDO INTERNATIONAL PLC	SHS	G30401906	4,164	601	SH	Call	DFND	1	0	601	0
ENDOCYTE INC	COM	29269A102	121	26,423	SH		DFND	1	0	26,423	0
ENDOLOGIX INC	COM	29266S106	1,226	100,000	SH		DFND	1	0	100,000	0
ENTEROMEDICS INC	COM	29365M208	536	2,063,336	SH		DFND	1	0	2,063,336	0
ESPERION THERAPEUTICS INC	COM	29664W105	566	23,990	SH		DFND	1	0	23,990	0
EXACT SCIENCES CORP	COM	30063P105	5,201	289,112	SH		DFND	1	0	289,112	0
EXACT SCIENCES CORP	COM	30063P955	7,723	4,293	SH	Put	DFND	1	0	4,293	0
EXELIXIS INC	COM	30161Q954	157	280	SH	Put	DFND	1	0	280	0
EXELIXIS INC	COM	30161Q904	1,000	1,783	SH	Call	DFND	1	0	1,783	0
EYEGATE PHARMACEUTICALS INC	COM	30233M107	695	243,790	SH		DFND	1	0	243,790	0
EYEGATE PHARMACEUTICALS WARRANTS	*W	30233M115	204	200,000	SH		DFND	1	0	200,000	0
FEI CO	COM	30241L909	2,483	340	SH	Call	DFND	1	0	340	0
FIBROGEN INC	COM	31572Q808	517	23,597	SH		DFND	1	0	23,597	0
FLUIDIGM CORP DEL	COM	34385P908	488	3,617	SH	Call	DFND	1	0	3,617	0
FLUIDIGM CORP DEL	COM	34385P108	5,095	628,260	SH		DFND	1	0	628,260	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	1,784	243,361	SH		DFND	1	0	243,361	0
FORWARD PHARMA A/S	ADR	34986J105	1,649	70,000	SH		DFND	1	0	70,000	0
GALENA BIOPHARMA INC	COM	363256958	1,081	6,832	SH	Put	DFND	1	0	6,832	0
GENOCEA BIOSCIENCES INC	COM	372427104	4,995	729,141	SH		DFND	1	0	729,141	0
GEVO INC	COM	374396208	9,819	100,000	SH		DFND	1	0	100,000	0
GILEAD SCIENCES INC	COM	375558103	4,432	45,140	SH		DFND	1	0	45,140	0
GILEAD SCIENCES INC	COM	375558953	48,830	4,973	SH	Put	DFND	1	0	4,973	0
GILEAD SCIENCES INC	COM	375558903	97,169	9,896	SH	Call	DFND	1	0	9,896	0
GLOBAL BLOOD THERAPEUTICS INC	COM	37890U108	14,455	342,857	SH		DFND	1	0	342,857	0
GLOBUS MEDICAL INC	CL A	379577208	345	16,700	SH		DFND	1	0	16,700	0
GLOBUS MEDICAL INC	CL A	379577958	1,886	913	SH	Put	DFND	1	0	913	0
GW PHARMACEUTICALS PLC	ADS	36197T903	914	100	SH	Call	DFND	1	0	100	0
GW PHARMACEUTICALS PLC	ADS	36197T103	6,556	71,757	SH		DFND	1	0	71,757	0
GW PHARMACEUTICALS PLC	ADS	36197T953	24,780	2,712	SH	Put	DFND	1	0	2,712	0
HALOZYME THERAPEUTICS INC	COM	40637H959	1,128	840	SH	Put	DFND	1	0	840	0
HALOZYME THERAPEUTICS INC	COM	40637H909	5,391	4,014	SH	Call	DFND	1	0	4,014	0
HCA HOLDINGS INC	COM	40412C901	4,827	624	SH	Call	DFND	1	0	624	0
HEARTWARE INTERNATIONAL INC	COM	422368100	915	17,500	SH		DFND	1	0	17,500	0
HEARTWARE INTERNATIONAL INC	COM	422368950	1,041	199	SH	Put	DFND	1	0	199	0
HEAT BIOLOGICS ORD SHS	COM	42237K102	149	32,201	SH		DFND	1	0	32,201	0
HERON THERAPEUTICS INC	COM	427746102	3,912	160,323	SH		DFND	1	0	160,323	0
HERON THERAPEUTICS INC	COM	427746902	10,304	4,223	SH	Call	DFND	1	0	4,223	0
HISTOGENICS CORP	COM	43358V109	110	27,505	SH		DFND	1	0	27,505	0
HORIZON PHARMA PLC	SHS	G4617B105	3,264	164,658	SH		DFND	1	0	164,658	0
HORIZON PHARMA PLC	SHS	G4617B955	3,286	1,658	SH	Put	DFND	1	0	1,658	0
IDERA PHARMACEUTICALS INC	COM	45168K956	372	1,111	SH	Put	DFND	1	0	1,111	0
IDERA PHARMACEUTICALS INC	COM	45168K306	461	137,700	SH		DFND	1	0	137,700	0
IDERA PHARMACEUTICALS INC	COM	45168K906	857	2,558	SH	Call	DFND	1	0	2,558	0
IGNYTA ORD SHS	COM	451731103	2,221	252,974	SH		DFND	1	0	252,974	0
IMMUNE DESIGN CORP	COM	45252L103	244	20,000	SH		DFND	1	0	20,000	0
IMMUNOCELLULAR THERAPEUTICS	COM	452536105	1,751	4,169,243	SH		DFND	1	0	4,169,243	0
INFINITY PHARMACEUTICALS INC	COM	45665G953	254	300	SH	Put	DFND	1	0	300	0
INFINITY PHARMACEUTICALS INC	COM	45665G303	254	30,000	SH		DFND	1	0	30,000	0
INFINITY PHARMACEUTICALS INC	COM	45665G903	1,665	1,971	SH	Call	DFND	1	0	1,971	0
INOTEK PHARMACEUTICALS CORP	COM	45780V102	1,034	110,000	SH		DFND	1	0	110,000	0
INOVIO PHARMACEUTICALS INC	COM	45773H901	2,292	3,965	SH	Call	DFND	1	0	3,965	0
INOVIO PHARMACEUTICALS INC	COM	45773H201	4,263	737,551	SH		DFND	1	0	737,551	0
INSMED INC	COM	457669907	949	511	SH	Call	DFND	1	0	511	0
INSMED INC	COM	457669957	1,419	764	SH	Put	DFND	1	0	764	0
INSPIREMD ORD SHS	COM	45779A309	153	927,876	SH		DFND	1	0	927,876	0
INTEC PHARMA LTD	SHS	M53644106	3,438	613,910	SH		DFND	1	0	613,910	0
INTELLIPHARMACEUTICS INTERNATIONAL INC	COM	458173951	47	187	SH	Put	DFND	1	0	187	0
INTEROIL CORP	COM	460951106	11,081	328,705	SH		DFND	1	0	328,705	0
INTEROIL CORP	COM	460951956	11,313	3,356	SH	Put	DFND	1	0	3,356	0
INTRA-CELLULAR THERAPIES INC	COM	46116X901	5,518	1,378	SH	Call	DFND	1	0	1,378	0
INTREXON CORP	COM	46122T952	426	134	SH	Put	DFND	1	0	134	0
INTREXON CORP	COM	46122T902	1,034	325	SH	Call	DFND	1	0	325	0
INVIVO THERAPEUTICS HOLDINGS CORP	COM	46186M909	2,248	2,608	SH	Call	DFND	1	0	2,608	0
ISHARES RUSSELL 2000 ETF	ETF	464287655	35,727	327,168	SH		DFND	1	0	327,168	0
ISHARES RUSSELL 2000 ETF	ETF	464287955	273,123	25,500	SH	Put	DFND	1	0	25,500	0
ISIS PHARMACEUTICALS INC	COM	464330909	4,685	1,159	SH	Call	DFND	1	0	1,159	0
KERYX BIOPHARMACEUTICALS INC	COM	492515951	56	158	SH	Put	DFND	1	0	158	0
KITE PHARMA INC	COM	49803L109	7,634	137,099	SH		DFND	1	0	137,099	0
KITE PHARMA INC	COM	49803L959	10,150	1,823	SH	Put	DFND	1	0	1,823	0
KONINKLIJKE PHILIPS N V	COM	500472903	5,569	2,374	SH	Call	DFND	1	0	2,374	0
LA JOLLA PHARMACEUTICAL CO	COM	503459604	2,362	85,011	SH		DFND	1	0	85,011	0
LEXICON PHARMACEUTICALS INC	COM	528872952	279	260	SH	Put	DFND	1	0	260	0
LEXICON PHARMACEUTICALS INC	COM	528872902	548	510	SH	Call	DFND	1	0	510	0
LEXICON PHARMACEUTICALS INC	COM	528872302	2,810	261,595	SH		DFND	1	0	261,595	0
LION BIOTECHNOLOGIES INC	COM	53619R102	3,237	561,894	SH		DFND	1	0	561,894	0
LIPOCINE INC	COM	53630X104	2,383	201,409	SH		DFND	1	0	201,409	0
LPATH INC.	COM	548910306	213	1,086,171	SH		DFND	1	0	1,086,171	0
MACROGENICS INC	COM	556099909	244	114	SH	Call	DFND	1	0	114	0
MANNKIND CORP	COM	56400P201	173	53,800	SH		DFND	1	0	53,800	0
MANNKIND CORP	COM	56400P951	6,701	20,875	SH	Put	DFND	1	0	20,875	0
MANNKIND CORP	COM	56400P901	9,929	30,930	SH	Call	DFND	1	0	30,930	0
MEDGENICS EQUITY WARRANTS	*W	58436Q112	2,544	1,453,640	SH		DFND	1	0	1,453,640	0
MEDICINES CO	COM	584688905	44,599	11,749	SH	Call	DFND	1	0	11,749	0
MEDICINES CO 1.375%	DBCV	584688AC9	7,278	5,000,000	SH		DFND	1	0	5,000,000	0
MEDICINOVA ORD SHS	COM	58468P206	1,420	500,000	SH		DFND	1	0	500,000	0
MEI PHARMA ORD SHS	COM	55279B202	464	295,491	SH		DFND	1	0	295,491	0
MELA SCIENCES INC.	COM	55277R308	750	657,860	SH		DFND	1	0	657,860	0
MERRIMACK PHARMACEUTICALS INC	COM	590328900	426	500	SH	Call	DFND	1	0	500	0
MIRATI THERAPEUTICS INC	COM	60468T105	2,065	60,000	SH		DFND	1	0	60,000	0
MOBILEYE N.V.	ORD	N51488907	3,120	686	SH	Call	DFND	1	0	686	0
MOBILEYE N.V.	ORD	N51488117	10,725	235,819	SH		DFND	1	0	235,819	0
MOBILEYE N.V.	ORD	N51488957	23,459	5,158	SH	Put	DFND	1	0	5,158	0
MOMENTA PHARMACEUTICALS INC	COM	60877T100	821	50,030	SH		DFND	1	0	50,030	0
MOMENTA PHARMACEUTICALS INC	COM	60877T900	1,641	1,000	SH	Call	DFND	1	0	1,000	0
MYLAN N.V.	SHS	N59465909	7,033	1,747	SH	Call	DFND	1	0	1,747	0
MYLAN N.V.	SHS	N59465109	15,171	376,827	SH		DFND	1	0	376,827	0
MYLAN N.V.	SHS	N59465959	23,174	5,756	SH	Put	DFND	1	0	5,756	0
NANOSPHERE ORD SHS	COM	63009F204	297	181,946	SH		DFND	1	0	181,946	0
NATERA ORD SHS	COM	632307104	939	86,523	SH		DFND	1	0	86,523	0
NEUROCRINE BIOSCIENCES INC	COM	64125C959	4,397	1,267	SH	Put	DFND	1	0	1,267	0
NEUROCRINE BIOSCIENCES INC	COM	64125C909	5,583	1,403	SH	Call	DFND	1	0	1,403	0
NEURODERM LTD	ORD	M74231107	257	12,416	SH		DFND	1	0	12,416	0
NEUROMETRIX EQUITY WARRANTS	*W	641255138	3,052	12,212,278	SH		DFND	1	0	12,212,278	0
NEUROMETRIX INC	COM	641255302	771	873,454	SH		DFND	1	0	873,454	0
NEVRO CORP	COM	64157F103	421	9,066	SH		DFND	1	0	9,066	0
NEVRO CORP	COM	64157F903	942	203	SH	Call	DFND	1	0	203	0
NEVRO CORP	COM	64157F953	3,456	745	SH	Put	DFND	1	0	745	0
NEWLINK GENETICS CORP	COM	651511107	1,206	33,658	SH		DFND	1	0	33,658	0
NEWLINK GENETICS CORP	COM	651511957	1,541	430	SH	Put	DFND	1	0	430	0
NEWLINK GENETICS CORP	COM	651511907	13,264	3,701	SH	Call	DFND	1	0	3,701	0
NIVALIS THERAPEUTICS INC	COM	65481J109	4,990	384,734	SH		DFND	1	0	384,734	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P600	3,578	572,518	SH		DFND	1	0	572,518	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P950	3,776	6,042	SH	Put	DFND	1	0	6,042	0
NOVAVAX INC	COM	670002904	2,841	4,018	SH	Call	DFND	1	0	4,018	0
NOVAVAX INC	COM	670002104	3,726	527,040	SH		DFND	1	0	527,040	0
NOVAVAX INC	COM	670002954	5,952	8,418	SH	Put	DFND	1	0	8,418	0
NOVO NORDISK A/S SHS	ADR	670100955	456	84	SH	Put	DFND	1	0	84	0
NUVASIVE INC	COM	670704905	1,543	320	SH	Call	DFND	1	0	320	0
NUVASIVE INC	COM	670704105	1,688	35,000	SH		DFND	1	0	35,000	0
OCERA THERAPEUTICS INC	COM	67552A108	1,348	426,544	SH		DFND	1	0	426,544	0
OCULAR THERAPEUTIX INC	COM	67576A900	162	115	SH	Call	DFND	1	0	115	0
OCULAR THERAPEUTIX INC	COM	67576A100	1,479	105,190	SH		DFND	1	0	105,190	0
OMEROS CORP	COM	682143102	464	42,377	SH		DFND	1	0	42,377	0
OMEROS CORP	COM	682143902	1,632	1,489	SH	Call	DFND	1	0	1,489	0
ONCOSEC MEDICAL INC	COM	68234L207	1,752	340,169	SH		DFND	1	0	340,169	0
OPEXA THERAPEUTICS EQUITY WARRANTS	*W	68372T129	46	382,765	SH		DFND	1	0	382,765	0
OPHTHOTECH CORP	COM	683745903	567	140	SH	Call	DFND	1	0	140	0
OPKO HEALTH INC	COM	68375N903	3,785	4,500	SH	Call	DFND	1	0	4,500	0
OPKO HEALTH INC	COM	68375N103	5,173	615,157	SH		DFND	1	0	615,157	0
OPKO HEALTH INC	COM	68375N953	5,429	6,456	SH	Put	DFND	1	0	6,456	0
ORAMED PHARMACEUTICALS INC	COM	68403P203	58	10,558	SH		DFND	1	0	10,558	0
OVASCIENCE INC	COM	69014Q901	588	692	SH	Call	DFND	1	0	692	0
OVASCIENCE INC	COM	69014Q951	1,868	2,200	SH	Put	DFND	1	0	2,200	0
OVASCIENCE INC	COM	69014Q101	2,530	297,955	SH		DFND	1	0	297,955	0
OXIGENE INC	COM	691828404	305	328,431	SH		DFND	1	0	328,431	0
PACIRA PHARMACEUTICALS INC	COM	695127100	1,278	31,100	SH		DFND	1	0	31,100	0
PARATEK PHARMACEUTICALS INC	COM	699374302	2,224	117,046	SH		DFND	1	0	117,046	0
PEREGRINE PHARMACEUTICALS INC	COM	713661304	215	10,907	SH		DFND	1	0	10,907	0
PERRIGO CO. PLC	SHS	G97822903	7,722	491	SH	Call	DFND	1	0	491	0
PERSEON EQUITY WARRANTS	*W	715270112	355	1,743,292	SH		DFND	1	0	1,743,292	0
PERSEON INC	COM	715270203	177	569,985	SH		DFND	1	0	569,985	0
PIERIS PHARMACEUTICALS INC	COM	720795103	276	150,708	SH		DFND	1	0	150,708	0
PIONEER NATURAL RESOURCE INC	COM	723787957	15,035	1,236	SH	Put	DFND	1	0	1,236	0
PIONEER NATURAL RESOURCE INC	COM	723787107	15,035	123,600	SH		DFND	1	0	123,600	0
PLURISTEM THERAPEUTICS INC	COM	72940R952	53	292	SH	Put	DFND	1	0	292	0
PLURISTEM THERAPEUTICS INC	COM	72940R102	2,683	1,474,369	SH		DFND	1	0	1,474,369	0
PORTOLA PHARMACEUTICALS INC	COM	737010108	477	11,201	SH		DFND	1	0	11,201	0
PORTOLA PHARMACEUTICALS INC	COM	737010958	878	206	SH	Put	DFND	1	0	206	0
POZEN INC	COM	73941U102	1,167	200,000	SH		DFND	1	0	200,000	0
PROGENICS PHARMACEUTICALS INC	COM	743187906	480	840	SH	Call	DFND	1	0	840	0
PROQR THERAPEUTICS N V	SHS	N71542109	320	21,950	SH		DFND	1	0	21,950	0
PROVECTUS BIOPHARMACEUTICALS INC	COM	74373P108	1,140	1,982,137	SH		DFND	1	0	1,982,137	0
PTC THERAPEUTICS INC	COM	69366J950	318	119	SH	Put	DFND	1	0	119	0
PTC THERAPEUTICS INC	COM	69366J200	624	23,387	SH		DFND	1	0	23,387	0
PTC THERAPEUTICS INC	COM	69366J900	3,100	1,161	SH	Call	DFND	1	0	1,161	0
PUMA BIOTECHNOLOGY INC	COM	74587V907	1,470	195	SH	Call	DFND	1	0	195	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	2,012	26,704	SH		DFND	1	0	26,704	0
PUMA BIOTECHNOLOGY INC	COM	74587V957	2,170	288	SH	Put	DFND	1	0	288	0
QUEST RESOURCE HOLDING	COM	74836W104	1,795	3,148,401	SH		DFND	1	0	3,148,401	0
RADIUS HEALTH INC	COM	750469207	804	11,600	SH		DFND	1	0	11,600	0
RADIUS HEALTH INC	COM	750469907	4,006	578	SH	Call	DFND	1	0	578	0
RAPTOR PHARMACEUTICAL CORP	COM	75382F956	264	436	SH	Put	DFND	1	0	436	0
RAPTOR PHARMACEUTICAL CORP	COM	75382F906	4,410	7,289	SH	Call	DFND	1	0	7,289	0
RARE ELEMENT RESOURCES LTD	COM	75381M102	1,080	3,843,873	SH		DFND	1	0	3,843,873	0
REDHILL BIOPHARMA LTD	ADS	757468103	2,241	173,550	SH		DFND	1	0	173,550	0
REGENERON PHARMACEUTICALS INC	COM	75886F107	535	1,150	SH		DFND	1	0	1,150	0
REGENERON PHARMACEUTICALS INC	COM	75886F957	2,465	53	SH	Put	DFND	1	0	53	0
REGULUS THERAPEUTIC INC	COM	75915K101	2,332	356,504	SH		DFND	1	0	356,504	0
REGULUS THERAPEUTIC INC	COM	75915K901	7,931	12,127	SH	Call	DFND	1	0	12,127	0
RELYPSA INC	COM	759531906	555	300	SH	Call	DFND	1	0	300	0
RELYPSA INC	COM	759531106	1,295	69,980	SH		DFND	1	0	69,980	0
REPROS THERAPEUTICS INC	COM	76028H909	2,063	2,777	SH	Call	DFND	1	0	2,777	0
REPROS THERAPEUTICS INC	COM	76028H959	2,075	2,793	SH	Put	DFND	1	0	2,793	0
REVANCE THERAPEUTICS INC	COM	761330909	2,425	815	SH	Call	DFND	1	0	815	0
RICEBRAN TECHNOLOGIES	COM	762831204	1,975	901,973	SH		DFND	1	0	901,973	0
ROCKWELL MEDICAL INC	COM	774374102	358	46,469	SH		DFND	1	0	46,469	0
ROCKWELL MEDICAL INC	COM	774374952	381	494	SH	Put	DFND	1	0	494	0
SAGE THERAPEUTICS INC	COM	78667J908	1,062	251	SH	Call	DFND	1	0	251	0
SAGE THERAPEUTICS INC	COM	78667J108	1,694	40,019	SH		DFND	1	0	40,019	0
SANGAMO BIOSCIENCES INC	COM	800677906	121	215	SH	Call	DFND	1	0	215	0
SANGAMO BIOSCIENCES INC	COM	800677106	2,455	435,225	SH		DFND	1	0	435,225	0
SAREPTA THERAPEUTICS INC	COM	803607950	5,895	1,836	SH	Put	DFND	1	0	1,836	0
SAREPTA THERAPEUTICS INC	COM	803607900	21,421	6,671	SH	Call	DFND	1	0	6,671	0
SERES THERAPEUTICS INC	COM	81750R102	1,920	64,775	SH		DFND	1	0	64,775	0
SKYLINE MEDICAL UNITS	COM	830830105	3,454	447,944	SH		DFND	1	0	447,944	0
SKYSTAR BIO PHARMACEUTICAL	COM	830884300	141	147,926	SH		DFND	1	0	147,926	0
SORRENTO THERAPEUTICS INC	COM	83587F202	1,402	167,064	SH		DFND	1	0	167,064	0
SORRENTO THERAPEUTICS INC	COM	83587F902	1,909	2,275	SH	Call	DFND	1	0	2,275	0
SPARK THERAPEUTICS INC	COM	84652J953	5,755	1,379	SH	Put	DFND	1	0	1,379	0
SPARK THERAPEUTICS INC	COM	84652J903	5,851	1,402	SH	Call	DFND	1	0	1,402	0
SPDR S&P 500 ETF TRUST	UNIT	78462F953	306,773	16,250	SH	Put	DFND	1	0	16,250	0
SPDR SERIES TRUST	S&P BIOTECH	78464A950	19,571	3,144	SH	Put	DFND	1	0	3,144	0
STEMCELLS INC	COM	85857R204	856	2,039,122	SH		DFND	1	0	2,039,122	0
SUNEDISON INC	COM	86732Y909	718	1,000	SH	Call	DFND	1	0	1,000	0
SUPERCONDUCTOR TECHNOLOGIES INC	COM	867931404	494	796,934	SH		DFND	1	0	796,934	0
SYNERGY PHARMACEUTICALS EQUITY WARRANTS	*W	871639118	486	291,206	SH		DFND	1	0	291,206	0
SYNERGY PHARMACEUTICALS INC	COM	871639958	855	1,613	SH	Put	DFND	1	0	1,613	0
SYNERGY PHARMACEUTICALS INC	COM	871639908	1,476	2,785	SH	Call	DFND	1	0	2,785	0
T2 BIOSYSTEMS INC	COM	89853L104	1,354	154,521	SH		DFND	1	0	154,521	0
TENAX THERAPEUTICS INC	COM	88032L100	7,892	2,604,660	SH		DFND	1	0	2,604,660	0
TENET HEALTHCARE CORP	COM	88033G407	9,080	245,938	SH		DFND	1	0	245,938	0
TENET HEALTHCARE CORP	COM	88033G957	10,733	2,907	SH	Put	DFND	1	0	2,907	0
TENET HEALTHCARE CORP	COM	88033G907	28,595	7,745	SH	Call	DFND	1	0	7,745	0
TESARO INC	COM	881569957	802	200	SH	Put	DFND	1	0	200	0
TESARO INC	COM	881569107	802	20,000	SH		DFND	1	0	20,000	0
TETRAPHASE PHARMACEUTICALS INC.	COM	88165N105	606	81,185	SH		DFND	1	0	81,185	0
THERAPEUTICSMD INC	COM	88338N907	5,743	9,800	SH	Call	DFND	1	0	9,800	0
TOBIRA THERAPEUTICS INC	COM	88883P101	1,690	174,943	SH		DFND	1	0	174,943	0
TOKAI PHARMACEUTICALS ORD SHS	COM	88907J107	6,772	654,283	SH		DFND	1	0	654,283	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260201	837	158,140	SH		DFND	1	0	158,140	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260901	863	1,631	SH	Call	DFND	1	0	1,631	0
TRANSENTERIX INC	COM	89366M901	2,266	10,026	SH	Call	DFND	1	0	10,026	0
TRANSENTERIX INC	COM	89366M201	3,596	1,591,117	SH		DFND	1	0	1,591,117	0
TRANSITION THERAPEUTICS INC	COM	893716209	685	382,600	SH		DFND	1	0	382,600	0
TROVAGENE INC	COM	897238309	1,138	200,000	SH		DFND	1	0	200,000	0
TROVAGENE INC	COM	897238909	1,479	2,600	SH	Call	DFND	1	0	2,600	0
UNIQURE B.V.	SHS	N90064951	425	208	SH	Put	DFND	1	0	208	0
UNIQURE B.V.	SHS	N90064901	1,726	844	SH	Call	DFND	1	0	844	0
UNITED THERAPEUTICS CORP	COM	91307C902	12,048	918	SH	Call	DFND	1	0	918	0
VALEANT PHARMACEUTICALS INTERNATIONAL INC	COM	91911K102	209	1,171	SH		DFND	1	0	1,171	0
VALEANT PHARMACEUTICALS INTERNATIONAL INC	COM	91911K952	285	16	SH	Put	DFND	1	0	16	0
VAPOR CORP DEL	UNIT	922099502	2,015	225,387	SH		DFND	1	0	225,387	0
VASCULAR SOLUTIONS INC	COM	92231M109	1,209	37,296	SH		DFND	1	0	37,296	0
VASCULAR SOLUTIONS INC	COM	92231M959	1,967	607	SH	Put	DFND	1	0	607	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	3,124	30,000	SH		DFND	1	0	30,000	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	3,551	341	SH	Call	DFND	1	0	341	0
VIGGLE INC.	COM	92672V204	666	812,687	SH		DFND	1	0	812,687	0
VITAL THERAPIES INC	COM	92847R904	101	250	SH	Call	DFND	1	0	250	0
VITAL THERAPIES INC	COM	92847R104	156	38,700	SH		DFND	1	0	38,700	0
VITAL THERAPIES INC	COM	92847R954	404	1,000	SH	Put	DFND	1	0	1,000	0
VTV THERAPEUTICS INC	CL A	918385105	1,047	160,556	SH		DFND	1	0	160,556	0
XOMA CORP	COM	98419J907	38	500	SH	Call	DFND	1	0	500	0
XTL BIOPHARMACEUTICALS	ADR	98386D208	1,794	1,149,886	SH		DFND	1	0	1,149,886	0
ZAFGEN INC	COM	98885E953	946	296	SH	Put	DFND	1	0	296	0
ZAFGEN INC	COM	98885E903	3,067	960	SH	Call	DFND	1	0	960	0
ZELTIQ AESTHETICS INC	COM	98933Q108	320	10,000	SH		DFND	1	0	10,000	0
ZELTIQ AESTHETICS INC	COM	98933Q908	3,203	1,000	SH	Call	DFND	1	0	1,000	0
ZOGENIX INC	COM	98978L904	42,005	31,115	SH	Call	DFND	1	0	31,115	0
ZOSANO PHARMA INC	COM	98979H103	647	163,365	SH		DFND	1	0	163,365	0
ZS PHARMA INC	COM	98979G105	780	11,875	SH		DFND	1	0	11,875	0
ZS PHARMA INC	COM	98979G905	1,950	297	SH	Call	DFND	1	0	297	0
ZS PHARMA INC	COM	98979G955	4,202	640	SH	Put	DFND	1	0	640	0