Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y909	33,998	5,739	SH	Call	DFND	1	0	5,739	0
ABBVIE INC	COM	00287Y959	14,526	2,452	SH	Put	DFND	1	0	2,452	0
ABBVIE INC	COM	00287Y109	2,735	46,166	SH		DFND	1	0	46,166	0
ABEONA THERAPEUTICS INC	COM	00289Y107	1,008	300,000	SH		DFND	1	0	300,000	0
ACADIA PHARMACEUTICALS INC	COM	004225908	5,308	1,489	SH	Call	DFND	1	0	1,489	0
ACADIA PHARMACEUTICALS INC	COM	004225958	14,884	4,175	SH	Put	DFND	1	0	4,175	0
ACADIA PHARMACEUTICALS INC	COM	004225108	4,058	113,838	SH		DFND	1	0	113,838	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	6,342	5,878	SH	Call	DFND	1	0	5,878	0
ACORDA THERAPEUTICS INC 1.75%	NOTE	00484MAA4	11,112	9,600,000	PRN		DFND	1	0	9,600,000	0
ACURA PHARMACEUTICALS INC	COM	00509L802	1,841	727,865	SH		DFND	1	0	727,865	0
ADAMAS PHARMACEUTICALS INC	COM	00548A906	688	243	SH	Call	DFND	1	0	243	0
AERIE PHARMACEUTICALS INC	COM	00771V908	524	215	SH	Call	DFND	1	0	215	0
AETERNA ZENTARIS INC	COM	007975402	2,393	534,145	SH		DFND	1	0	534,145	0
AFFIMED NV	COM	N01045108	404	56,773	SH		DFND	1	0	56,773	0
ALCOBRA LTD	SHS	M2239P909	314	500	SH	Call	DFND	1	0	500	0
ALCOBRA LTD	SHS	M2239P109	1,052	167,500	SH		DFND	1	0	167,500	0
ALDEYRA THERAPEUTICS INC.	COM	01438T106	466	68,699	SH		DFND	1	0	68,699	0
ALEXION PHARMACEUTICALS INC	COM	015351909	2,899	152	SH	Call	DFND	1	0	152	0
ALEXION PHARMACEUTICALS INC	COM	015351959	18,598	975	SH	Put	DFND	1	0	975	0
ALEXION PHARMACEUTICALS INC	COM	015351109	373	1,956	SH		DFND	1	0	1,956	0
ALKERMES PLC	SHS	G01767105	10,452	131,671	SH		DFND	1	0	131,671	0
ALKERMES PLC	SHS	G01767905	4,509	568	SH	Call	DFND	1	0	568	0
ALKERMES PLC	SHS	G01767955	25,052	3,156	SH	Put	DFND	1	0	3,156	0
ALLIQUA BIOMEDICAL INC.	COM	019621200	1,423	664,791	SH		DFND	1	0	664,791	0
AMARIN CORPORATION PLC	ADR	023111906	1,641	8,683	SH	Call	DFND	1	0	8,683	0
AMARIN CORPORATION PLC	ADR	023111956	211	1,118	SH	Put	DFND	1	0	1,118	0
AMICUS THERAPEUTICS INC	COM	03152W909	1,685	1,737	SH	Call	DFND	1	0	1,737	0
AMICUS THERAPEUTICS INC	COM	03152W959	3,394	3,499	SH	Put	DFND	1	0	3,499	0
AMICUS THERAPEUTICS INC	COM	03152W109	249	25,661	SH		DFND	1	0	25,661	0
ANACOR PHARMACEUTICALS INC	COM	032420901	13,421	1,188	SH	Call	DFND	1	0	1,188	0
ANACOR PHARMACEUTICALS INC	COM	032420951	1,130	100	SH	Put	DFND	1	0	100	0
ANACOR PHARMACEUTICALS INC	COM	032420101	2,259	20,000	SH		DFND	1	0	20,000	0
ANTARES PHARMA INC	COM	036642906	105	866	SH	Call	DFND	1	0	866	0
ANTARES PHARMA INC	COM	036642106	918	758,718	SH		DFND	1	0	758,718	0
ANTHERA PHARMACEUTICALS INC	COM	03674U901	928	2,000	SH	Call	DFND	1	0	2,000	0
APPLE INC	COM	037833900	11,684	1,110	SH	Call	DFND	1	0	1,110	0
APPLE INC	COM	037833950	12,463	1,184	SH	Put	DFND	1	0	1,184	0
AQUINOX PHARMACEUTICALS INC	COM	03842B101	753	60,313	SH		DFND	1	0	60,313	0
ARBUTUS BIOPHARMA CORP	COM	03879J900	156	351	SH	Call	DFND	1	0	351	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	4,450	1,000,000	SH		DFND	1	0	1,000,000	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G107	1,858	195,132	SH		DFND	1	0	195,132	0
BARCLAYS BANK PLC	ETN	06740C519	5,850	525,132	SH		DFND	1	0	525,132	0
BELLICUM PHARMACEUTICALS INC	COM	079481907	5,931	2,926	SH	Call	DFND	1	0	2,926	0
BELLICUM PHARMACEUTICALS INC	COM	079481957	659	325	SH	Put	DFND	1	0	325	0
BENITEC BIOPHARMA LTD	ADR	082053307	2,377	597,115	SH		DFND	1	0	597,115	0
BENITEC BIOPHARMA LTD 8/14/202	*W	082053117	199	99,555	SH		DFND	1	0	99,555	0
BIOCRYST PHARMACEUTICALS	COM	09058V953	1,999	1,937	SH	Put	DFND	1	0	1,937	0
BIOCRYST PHARMACEUTICALS	COM	09058V103	1,708	165,529	SH		DFND	1	0	165,529	0
BIODEL INC SHS	COM	09064M954	6	182	SH	Put	DFND	1	0	182	0
BIODEL INC SHS	COM	09064M204	507	1,480,728	SH		DFND	1	0	1,480,728	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J906	862	1,800	SH	Call	DFND	1	0	1,800	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J956	862	1,800	SH	Put	DFND	1	0	1,800	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J106	2,958	617,496	SH		DFND	1	0	617,496	0
BIOGEN INC	COM	09062X903	105,292	3,437	SH	Call	DFND	1	0	3,437	0
BIOGEN INC	COM	09062X953	37,987	1,240	SH	Put	DFND	1	0	1,240	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G901	13,703	1,308	SH	Call	DFND	1	0	1,308	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G951	4,976	475	SH	Put	DFND	1	0	475	0
BIOMARIN PHARMACEUTICAL INC. 1.875%	NOTE	09061G101	6,475	5,000,000	PRN		DFND	1	0	5,000,000	0
BIOTIE THERAPIES OYJ	ADR	09074D103	714	50,460	SH		DFND	1	0	50,460	0
BLUEBIRD BIO INC	COM	09609G900	5,529	861	SH	Call	DFND	1	0	861	0
BLUEBIRD BIO INC	COM	09609G950	3,314	516	SH	Put	DFND	1	0	516	0
BLUEBIRD BIO INC	COM	09609G100	2,919	45,449	SH		DFND	1	0	45,449	0
BLUEPRINT MEDICINES CORP	COM	09627Y909	7,902	3,000	SH	Call	DFND	1	0	3,000	0
BRAINSTORM CELL THERAPEUTICS INC	COM	10501E201	2,201	769,534	SH		DFND	1	0	769,534	0
BRISTOL-MYERS SQUIBB CO	COM	110122908	11,343	1,649	SH	Call	DFND	1	0	1,649	0
CANCER GENETICS INC	COM	13739U104	209	63,251	SH		DFND	1	0	63,251	0
CAPRICOR THERAPEUTICS INC	COM	14070B101	570	185,664	SH		DFND	1	0	185,664	0
CARDICA INC.	COM	14141R101	1,328	8,569,181	SH		DFND	1	0	8,569,181	0
CASTLIGHT HEALTH INC	CL B	14862Q100	455	106,500	SH		DFND	1	0	106,500	0
CELATOR PHARMACEUTICALS INC.	COM	15089R102	594	337,462	SH		DFND	1	0	337,462	0
CELGENE CORP	COM	151020904	3,748	313	SH	Call	DFND	1	0	313	0
CELLDEX THERAPEUTICS INC	COM	15117B903	7,006	4,468	SH	Call	DFND	1	0	4,468	0
CELLDEX THERAPEUTICS INC	COM	15117B953	373	238	SH	Put	DFND	1	0	238	0
CELLECTAR BIOSCIENCES INC	COM	15117F203	633	857,600	SH		DFND	1	0	857,600	0
CELLECTAR BIOSCIENCES INC	*W	15117F112	365	653,712	SH		DFND	1	0	653,712	0
CELSION CORP.	COM	15117N404	36	18,789	SH		DFND	1	0	18,789	0
CELSION CORPORATION	COM	15117N954	105	546	SH	Put	DFND	1	0	546	0
CEMPRA INC	COM	15130J909	1,170	376	SH	Call	DFND	1	0	376	0
CEMPRA INC	COM	15130J959	1,292	415	SH	Put	DFND	1	0	415	0
CEMPRA INC	COM	15130J109	2,950	94,763	SH		DFND	1	0	94,763	0
CERES INC	COM	156773400	186	570,919	SH		DFND	1	0	570,919	0
CESCA THERAPEUTICS INC	COM	157131103	387	2,124,558	SH		DFND	1	0	2,124,558	0
CHAMPIONS ONCOLOGY INC	COM	15870P307	1,041	291,595	SH		DFND	1	0	291,595	0
CHINA MOBILE LIMITED	ADR	16941M909	2,709	481	SH	Call	DFND	1	0	481	0
CLOVIS ONCOLOGY INC	COM	189464900	875	250	SH	Call	DFND	1	0	250	0
CLOVIS ONCOLOGY INC	COM	189464100	732	20,923	SH		DFND	1	0	20,923	0
CONATUS PHARMACEUTICALS INC	COM	20600T108	254	88,210	SH		DFND	1	0	88,210	0
CTI BIOPHARMA CORP	COM	12648L906	707	5,747	SH	Call	DFND	1	0	5,747	0
CTI BIOPHARMA CORP	COM	12648L106	708	575,669	SH		DFND	1	0	575,669	0
CYCLACEL PHARMACEUTICALS INC.	COM	23254L306	755	1,510,806	SH		DFND	1	0	1,510,806	0
CYMABAY THERAPEUTICS INC	COM	23257D103	1,004	593,900	SH		DFND	1	0	593,900	0
CYNAPSUS THERAPEUTICS INC	COM	23257Y859	905	58,610	SH		DFND	1	0	58,610	0
CYTORI THERAPEUTICS INC.	COM	23283K105	3,190	17,150,297	SH		DFND	1	0	17,150,297	0
CYTRX CORP	COM	232828909	45	170	SH	Call	DFND	1	0	170	0
DBV TECHNOLOGIES S A	ADR	23306J101	1,692	46,587	SH		DFND	1	0	46,587	0
DEPOMED INC	COM	249908904	7,198	3,970	SH	Call	DFND	1	0	3,970	0
DEPOMED INC	COM	249908954	408	225	SH	Put	DFND	1	0	225	0
DERMIRA INC	COM	24983L954	280	100	SH	Put	DFND	1	0	100	0
DISCOVERY LABORATORIES INC*	COM	254668403	1,570	7,339,548	SH		DFND	1	0	7,339,548	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	4,607	1,907	SH	Call	DFND	1	0	1,907	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	1,375	569	SH	Put	DFND	1	0	569	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	2,899	120,000	SH		DFND	1	0	120,000	0
EDAP TMS SA	ADR	268311957	349	846	SH	Put	DFND	1	0	846	0
EDWARDS LIFESCIENCES CORP	COM	28176E958	9,478	1,200	SH	Put	DFND	1	0	1,200	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	482	6,107	SH		DFND	1	0	6,107	0
ELEVEN BIOTHERAPEUTICS INC.	COM	286221106	584	194,041	SH		DFND	1	0	194,041	0
ELI LILLY & CO	COM	532457908	200,488	23,794	SH	Call	DFND	1	0	23,794	0
ELI LILLY & CO	COM	532457958	23,627	2,804	SH	Put	DFND	1	0	2,804	0
ENDO INTERNATIONAL PLC	SHS	G30401906	6,581	1,075	SH	Call	DFND	1	0	1,075	0
ENDO INTERNATIONAL PLC	SHS	G30401956	337	55	SH	Put	DFND	1	0	55	0
ENDOLOGIX ORD SHS	COM	29266S106	990	100,000	SH		DFND	1	0	100,000	0
ESPERION THERAPEUTICS INC	COM	29664W105	423	19,000	SH		DFND	1	0	19,000	0
EXELIXIS INC	COM	30161Q904	1,006	1,783	SH	Call	DFND	1	0	1,783	0
EXELIXIS INC	COM	30161Q954	158	280	SH	Put	DFND	1	0	280	0
EYEGATE PHARMACEUTICALS INC	COM	30233M107	624	227,660	SH		DFND	1	0	227,660	0
EYEGATE PHARMACEUTICALS WARRANTS EXP 08/05/202	*W	30233M115	131	174,150	SH		DFND	1	0	174,150	0
FLAMEL TECHNOLOGIE SA	ADR	338488959	232	190	SH	Put	DFND	1	0	190	0
FLAMEL TECHNOLOGIE SA	ADR	338488109	148	12,100	SH		DFND	1	0	12,100	0
FLUIDIGM CORP	COM	34385P908	3,580	3,312	SH	Call	DFND	1	0	3,312	0
FLUIDIGM CORP	COM	34385P108	2,856	264,196	SH		DFND	1	0	264,196	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	1,933	238,400	SH		DFND	1	0	238,400	0
FORWARD PHARMA A/S	ADR	34986J105	1,330	70,000	SH		DFND	1	0	70,000	0
GALECTIN THERAPEUTICS INC	COM	363225202	1,782	1,086,615	SH		DFND	1	0	1,086,615	0
GALENA BIOPHARMA INC	COM	363256958	1,006	6,842	SH	Put	DFND	1	0	6,842	0
GENOCEA BIOSCIENCES INC	COM	372427104	823	156,134	SH		DFND	1	0	156,134	0
GILEAD SCIENCES INC	COM	375558903	98,701	9,754	SH	Call	DFND	1	0	9,754	0
GILEAD SCIENCES INC	COM	375558953	9,249	914	SH	Put	DFND	1	0	914	0
GLOBAL BLOOD THERAPEUTICS	COM	37890U108	6,446	342,857	SH		DFND	1	0	342,857	0
GW PHARMACEUTICALS PLC	ADS	36197T103	11,139	160,406	SH		DFND	1	0	160,406	0
GW PHARMACEUTICALS PLC	ADS	36197T903	694	100	SH	Call	DFND	1	0	100	0
GW PHARMACEUTICALS PLC	ADS	36197T953	22,103	3,183	SH	Put	DFND	1	0	3,183	0
HALOZYME THERAPEUTICS INC	COM	40637H909	6,956	4,014	SH	Call	DFND	1	0	4,014	0
HALOZYME THERAPEUTICS INC	COM	40637H959	1,456	840	SH	Put	DFND	1	0	840	0
HCA HOLDINGS INC	COM	40412C901	4,220	624	SH	Call	DFND	1	0	624	0
HEARTWARE INTERNATIONAL INC	COM	422368950	1,003	199	SH	Put	DFND	1	0	199	0
HEARTWARE INTERNATIONAL INC	COM	422368100	1,003	19,900	SH		DFND	1	0	19,900	0
HEAT BIOLOGICS INC	COM	42237K102	54	21,971	SH		DFND	1	0	21,971	0
HERON THERAPEUTICS INC	COM	427746902	278	104	SH	Call	DFND	1	0	104	0
HISTOGENICS CORP.	COM	43358V109	412	117,665	SH		DFND	1	0	117,665	0
IDERA PHARMACEUTICALS INC	COM	45168K906	836	2,707	SH	Call	DFND	1	0	2,707	0
IGNYTA INC	COM	451731103	725	54,099	SH		DFND	1	0	54,099	0
IMMUNOCELLULAR THERAPEUTICS	COM	452536105	1,579	4,443,914	SH		DFND	1	0	4,443,914	0
INFINITY PHARMACEUTICALS INC	COM	45665G903	1,547	1,971	SH	Call	DFND	1	0	1,971	0
INOTEK PHARMACEUTICALS CORP	COM	45780V102	993	87,652	SH		DFND	1	0	87,652	0
INOVIO PHARMACEUTICALS INC	COM	45773H901	2,682	3,991	SH	Call	DFND	1	0	3,991	0
INOVIO PHARMACEUTICALS INC	COM	45773H201	4,161	619,185	SH		DFND	1	0	619,185	0
INSMED INC	COM	457669907	592	326	SH	Call	DFND	1	0	326	0
INSMED INC	COM	457669957	1,579	870	SH	Put	DFND	1	0	870	0
INSPIREMD INC1.75WTS EXP 05/08/2018	COM	45779A309	83	92,787	SH		DFND	1	0	92,787	0
INTEC PHARMA LTD JERUSALEM	SHS	M53644106	3,594	670,449	SH		DFND	1	0	670,449	0
INTELLIPHARMACEUTICS INTERNATIONAL INC	COM	458173951	33	165	SH	Put	DFND	1	0	165	0
INTRA-CELLULAR THERAPIES INC	COM	46116X901	538	100	SH	Call	DFND	1	0	100	0
INTRA-CELLULAR THERAPIES INC	COM	46116X951	2,797	520	SH	Put	DFND	1	0	520	0
INTREXON CORP	COM	46122T902	980	325	SH	Call	DFND	1	0	325	0
INTREXON CORP	COM	46122T952	404	134	SH	Put	DFND	1	0	134	0
INTREXON CORP	COM	46122T102	331	10,995	SH		DFND	1	0	10,995	0
INVIVO THERAPEUTICS HOLDINGS CORP	COM	46186M909	1,872	2,600	SH	Call	DFND	1	0	2,600	0
IONIS PHARMACEUTICALS INC	COM	462222900	7,178	1,159	SH	Call	DFND	1	0	1,159	0
ISHARES RUSSELL 2000 ETF	ETF	464287655	33,123	294,400	SH		DFND	1	0	294,400	0
ISHARES RUSSELL 2000 ETF	ETF	464287955	196,881	17,499	SH	Put	DFND	1	0	17,499	0
KERYX BIOPHARMACEUTICALS	COM	492515951	80	158	SH	Put	DFND	1	0	158	0
KITE PHARMA INC	COM	49803L959	4,979	808	SH	Put	DFND	1	0	808	0
KITE PHARMA INC	COM	49803L109	1,021	16,571	SH		DFND	1	0	16,571	0
KITOV PHARMACEUTICALS HOLDINGS WARRANTS 11/20/202	*W	49803V115	56	114,720	SH		DFND	1	0	114,720	0
LA JOLLA PHARMACEUTICAL CO	COM	503459604	1,759	65,158	SH		DFND	1	0	65,158	0
LANNETT INC	COM	516012901	2,070	516	SH	Call	DFND	1	0	516	0
LEXICON PHARMACEUTICALS INC	COM	528872902	3,640	2,735	SH	Call	DFND	1	0	2,735	0
LEXICON PHARMACEUTICALS INC	COM	528872302	901	67,710	SH		DFND	1	0	67,710	0
LION BIOTECHNOLOGIES INC	COM	53619R902	1,894	2,453	SH	Call	DFND	1	0	2,453	0
LION BIOTECHNOLOGIES INC	COM	53619R102	2,084	270,000	SH		DFND	1	0	270,000	0
LIPOCINE INC	COM	53630X904	453	350	SH	Call	DFND	1	0	350	0
LIPOCINE INC	COM	53630X104	1,968	152,221	SH		DFND	1	0	152,221	0
LPATH INC	COM	548910306	249	1,106,870	SH		DFND	1	0	1,106,870	0
MACROGENICS INC	COM	556099909	353	114	SH	Call	DFND	1	0	114	0
MACROGENICS INC	COM	556099959	248	80	SH	Put	DFND	1	0	80	0
MANNKIND CORP	COM	56400P901	5,153	35,535	SH	Call	DFND	1	0	35,535	0
MANNKIND CORP	COM	56400P951	2,945	20,310	SH	Put	DFND	1	0	20,310	0
MANNKIND CORP	COM	56400P201	922	635,903	SH		DFND	1	0	635,903	0
MEDGENICS EQUITY WARRANTS EXP 03/31/201	*W	58436Q112	1,377	1,529,526	SH		DFND	1	0	1,529,526	0
MEDICINES CO	COM	584688905	23,703	6,348	SH	Call	DFND	1	0	6,348	0
MEDICINES CO 1.375%	DBCV	584688AC9	2,152	1,500,000	PRN		DFND	1	0	1,500,000	0
MEDICINOVA INC	COM	58468P206	1,686	474,803	SH		DFND	1	0	474,803	0
MEI PHARMA INC	COM	55279B202	320	200,000	SH		DFND	1	0	200,000	0
MELA SCIENCES INC **	COM	55277R308	1,021	911,781	SH		DFND	1	0	911,781	0
MIRATI THERAPEUTICS INC.	COM	60468T105	822	26,027	SH		DFND	1	0	26,027	0
MOBILEYE N.V. REG.	ORD	N51488907	1,949	461	SH	Call	DFND	1	0	461	0
MOBILEYE N.V. REG.	ORD	N51488957	8,503	2,011	SH	Put	DFND	1	0	2,011	0
MOBILEYE N.V. REG.	ORD	N51488117	7,258	171,672	SH		DFND	1	0	171,672	0
MOMENTA PHARMACEUTICALS INC	COM	60877T100	2,226	150,030	SH		DFND	1	0	150,030	0
MYLAN N.V.	SHS	N59465909	13,258	2,452	SH	Call	DFND	1	0	2,452	0
MYLAN N.V.	SHS	N59465959	14,772	2,732	SH	Put	DFND	1	0	2,732	0
NANOSPHERE ORD SHS	COM	63009F204	102	166,234	SH		DFND	1	0	166,234	0
NATERA ORD SHS	COM	632307104	936	86,623	SH		DFND	1	0	86,623	0
NEUROCRINE BIOSCIENCES INC	COM	64125C909	7,224	1,277	SH	Call	DFND	1	0	1,277	0
NEUROCRINE BIOSCIENCES INC	COM	64125C959	1,363	241	SH	Put	DFND	1	0	241	0
NEURODERM LTD	SHS	M74231957	1,110	651	SH	Put	DFND	1	0	651	0
NEUROMETRIX EQUITY WARRANTS EX 05/29/202	*W	641255153	953	3,117,833	SH		DFND	1	0	3,117,833	0
NEUROMETRIX INC	COM	641255500	650	328,467	SH		DFND	1	0	328,467	0
NEVRO CORP	COM	64157F903	2,032	301	SH	Call	DFND	1	0	301	0
NEVRO CORP	COM	64157F953	5,387	798	SH	Put	DFND	1	0	798	0
NEWLINK GENETICS CORP	COM	651511907	8,119	2,231	SH	Call	DFND	1	0	2,231	0
NEWLINK GENETICS CORP	COM	651511957	1,696	466	SH	Put	DFND	1	0	466	0
NEWLINK GENETICS CORP	COM	651511107	6,232	171,266	SH		DFND	1	0	171,266	0
NIVALIS THERAPEUTICS INC	COM	65481J109	3,898	503,595	SH		DFND	1	0	503,595	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P950	373	1,165	SH	Put	DFND	1	0	1,165	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P600	2,937	917,942	SH		DFND	1	0	917,942	0
NOVAVAX INC	COM	670002904	3,371	4,018	SH	Call	DFND	1	0	4,018	0
NOVAVAX INC	COM	670002954	906	1,080	SH	Put	DFND	1	0	1,080	0
NOVO-NORDISK A/S	ADR	670100905	5,053	870	SH	Call	DFND	1	0	870	0
NUVASIVE INC	COM	670704105	812	15,000	SH		DFND	1	0	15,000	0
OASMIA PHARMACEUTICAL AB	ADR	67421W109	2,401	663,138	SH		DFND	1	0	663,138	0
OCATA THERAPEUTICS INC	COM	67457L950	525	624	SH	Put	DFND	1	0	624	0
OCERA THERAPEUTICS ORD SHS	COM	67552A108	1,202	385,300	SH		DFND	1	0	385,300	0
OCULAR THERAPEUTIX INC	COM	67576A900	94	100	SH	Call	DFND	1	0	100	0
OCULAR THERAPEUTIX INC	COM	67576A100	843	90,000	SH		DFND	1	0	90,000	0
OMEROS CORP	COM	682143902	2,264	1,439	SH	Call	DFND	1	0	1,439	0
OMEROS CORP	COM	682143102	369	23,450	SH		DFND	1	0	23,450	0
ONCOSEC MEDICAL INC	COM	68234L207	2,902	1,224,359	SH		DFND	1	0	1,224,359	0
OPEXA THERAPEUTICS EQUITY WARRANTS 03/13/201	*W	68372T202	10	99,268	SH		DFND	1	0	99,268	0
OPKO HEALTH INC	COM	68375N903	4,523	4,500	SH	Call	DFND	1	0	4,500	0
OPKO HEALTH INC	COM	68375N953	958	953	SH	Put	DFND	1	0	953	0
OPKO HEALTH INC	COM	68375N103	983	97,811	SH		DFND	1	0	97,811	0
OVASCIENCE INC	COM	69014Q901	489	500	SH	Call	DFND	1	0	500	0
OXIGENE INC	COM	691828404	160	214,924	SH		DFND	1	0	214,924	0
PACIRA PHARMACEUTICALS INC	COM	695127900	4,246	553	SH	Call	DFND	1	0	553	0
PARATEK PHARMACEUTICALS INC	COM	699374302	2,326	122,613	SH		DFND	1	0	122,613	0
PERSEON CORP.	COM	715270203	4	16,451	SH		DFND	1	0	16,451	0
PERSEON EQUITY WARRANTS	*W	715270112	49	1,887,892	SH		DFND	1	0	1,887,892	0
PIERIS PHARMACEUTICALS	COM	720795103	172	75,208	SH		DFND	1	0	75,208	0
PLURISTEM THERAPEUTICS INC.	COM	72940R102	2,048	1,812,668	SH		DFND	1	0	1,812,668	0
PORTOLA PHARMACEUTICALS INC	COM	737010908	602	117	SH	Call	DFND	1	0	117	0
PORTOLA PHARMACEUTICALS INC	COM	737010958	1,122	218	SH	Put	DFND	1	0	218	0
PORTOLA PHARMACEUTICALS INC	COM	737010108	201	3,900	SH		DFND	1	0	3,900	0
POZEN INC	COM	73941U102	1,365	199,800	SH		DFND	1	0	199,800	0
PROGENICS PHARMACEUTICALS INC	COM	743187906	515	840	SH	Call	DFND	1	0	840	0
PROQR THERAPEUTICS N V	SHS	N71542109	346	39,871	SH		DFND	1	0	39,871	0
PROVECTUS BIOPHARMACEUTICALS INC	COM	74373P108	724	1,856,019	SH		DFND	1	0	1,856,019	0
PSIVIDA CORP	COM	74440J951	165	343	SH	Put	DFND	1	0	343	0
PTC THERAPEUTICS INC	COM	69366J900	2,738	845	SH	Call	DFND	1	0	845	0
PTC THERAPEUTICS INC	COM	69366J950	2,168	669	SH	Put	DFND	1	0	669	0
QUEST RESOURCE HOLDING CORP.	COM	74836W104	1,631	2,435,037	SH		DFND	1	0	2,435,037	0
RADIUS HEALTH INC	COM	750469907	3,557	578	SH	Call	DFND	1	0	578	0
RAPTOR PHARMACEUTICAL CORP	COM	75382F906	368	707	SH	Call	DFND	1	0	707	0
RARE ELEMENT RESOURCES LTD	COM	75381M102	519	3,436,858	SH		DFND	1	0	3,436,858	0
REDHILL BIOPHARMA LTD	ADS	757468103	2,063	160,144	SH		DFND	1	0	160,144	0
REGENXBIO INC.	COM	75901B107	1,940	116,860	SH		DFND	1	0	116,860	0
REGULUS THERAPEUTIC INC	COM	75915K901	10,440	11,973	SH	Call	DFND	1	0	11,973	0
REGULUS THERAPEUTIC INC	COM	75915K951	436	500	SH	Put	DFND	1	0	500	0
REGULUS THERAPEUTIC INC	COM	75915K101	1,831	210,000	SH		DFND	1	0	210,000	0
RELYPSA INC	COM	759531906	2,919	1,030	SH	Call	DFND	1	0	1,030	0
RENNOVA HEALTH INC.	COM	759757107	41	30,222	SH		DFND	1	0	30,222	0
RENNOVA HEALTH INC. WARRANTS	*W	759757115	1,427	3,225,806	SH		DFND	1	0	3,225,806	0
REPROS THERAPEUTICS INC	COM	76028H909	276	2,277	SH	Call	DFND	1	0	2,277	0
REVANCE THERAPEUTICS INC	COM	761330909	2,849	834	SH	Call	DFND	1	0	834	0
RICEBRAN TECHNOLOGIES	COM	762831204	1,773	933,441	SH		DFND	1	0	933,441	0
ROCKWELL MEDICAL INC	COM	774374952	132	129	SH	Put	DFND	1	0	129	0
ROCKWELL MEDICAL INC	COM	774374102	132	12,900	SH		DFND	1	0	12,900	0
ROSETTA GENOMICS LTD	SHS	M82183126	196	158,951	SH		DFND	1	0	158,951	0
ROYAL PHILIPS NV	SHS	500472903	6,042	2,374	SH	Call	DFND	1	0	2,374	0
SAGE THERAPEUTICS INC	COM	78667J908	414	71	SH	Call	DFND	1	0	71	0
SAGE THERAPEUTICS INC	COM	78667J108	474	8,123	SH		DFND	1	0	8,123	0
SANGAMO BIOSCIENCES INC	COM	800677906	1,118	1,225	SH	Call	DFND	1	0	1,225	0
SANGAMO BIOSCIENCES INC	COM	800677106	1,197	131,100	SH		DFND	1	0	131,100	0
SAREPTA THERAPEUTICS INC	COM	803607900	11,042	2,862	SH	Call	DFND	1	0	2,862	0
SAREPTA THERAPEUTICS INC	COM	803607950	12,739	3,302	SH	Put	DFND	1	0	3,302	0
SERES THERAPEUTICS INC	COM	81750R902	235	67	SH	Call	DFND	1	0	67	0
SERES THERAPEUTICS INC	COM	81750R102	368	10,495	SH		DFND	1	0	10,495	0
SKYLINE MEDICAL	UNIT	83084T408	3,268	453,944	SH		DFND	1	0	453,944	0
SORRENTO THERAPEUTICS INC.	COM	83587F202	2,613	300,000	SH		DFND	1	0	300,000	0
SPARK THERAPEUTICS INC	COM	84652J903	3,489	770	SH	Call	DFND	1	0	770	0
SPDR S&P 500 ETF TRUST	UNIT	78462F953	183,501	9,000	SH	Put	DFND	1	0	9,000	0
SPDR SERIES TRUST	S&P BIOTECH	78464A950	41,207	5,880	SH	Put	DFND	1	0	5,880	0
SPECTRANETICS CORP	COM	84760C907	316	210	SH	Call	DFND	1	0	210	0
STEMCELLS INC.	COM	85857R204	77	184,158	SH		DFND	1	0	184,158	0
SUNEDISON INC	COM	86732Y909	509	1,000	SH	Call	DFND	1	0	1,000	0
SUPERCONDUCTOR TECHNOLOGIES ORD SHS	COM	867931404	493	2,349,992	SH		DFND	1	0	2,349,992	0
SYNERGY PHARMACEUTICALS EQUITY WARRANTS 12/06/201	*W	871639118	1,652	291,306	SH		DFND	1	0	291,306	0
SYNERGY PHARMACEUTICALS INC	COM	871639908	1,579	2,785	SH	Call	DFND	1	0	2,785	0
T2 BIOSYSTEMS INC.	COM	89853L104	2,522	230,542	SH		DFND	1	0	230,542	0
TENAX THERAPEUTICS INC.	COM	88032L100	8,835	2,693,537	SH		DFND	1	0	2,693,537	0
TENET HEALTHCARE CORP	COM	88033G907	4,681	1,545	SH	Call	DFND	1	0	1,545	0
THERAPEUTICSMD INC	COM	88338N907	6,216	5,994	SH	Call	DFND	1	0	5,994	0
THERAPEUTICSMD INC	COM	88338N957	419	404	SH	Put	DFND	1	0	404	0
THRESHOLD PHARMACEUTICALS INC.	COM	885807206	609	1,268,717	SH		DFND	1	0	1,268,717	0
THRESHOLD PHARMACEUTICALS INC.	COM	885807906	58	1,203	SH	Call	DFND	1	0	1,203	0
TOBIRA THERAPEUTICS INC	COM	88883P101	1,070	106,507	SH		DFND	1	0	106,507	0
TOKAI PHARMACEUTICALS INC	COM	88883P101	6,722	770,835	SH		DFND	1	0	770,835	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260901	1,329	1,733	SH	Call	DFND	1	0	1,733	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260201	1,193	155,557	SH		DFND	1	0	155,557	0
TRANSENTERIX INC	COM	89366M901	3,839	15,481	SH	Call	DFND	1	0	15,481	0
TRANSENTERIX INC	COM	89366M201	3,773	1,521,505	SH		DFND	1	0	1,521,505	0
TRANSITION THERAPEUTICS INC.	COM	893716209	124	64,500	SH		DFND	1	0	64,500	0
TROVAGENE INC	COM	897238909	1,404	2,600	SH	Call	DFND	1	0	2,600	0
TROVAGENE INC	COM	897238309	865	160,140	SH		DFND	1	0	160,140	0
UNIQURE NV	SHS	N90064901	1,571	950	SH	Call	DFND	1	0	950	0
UNIQURE NV	SHS	N90064951	344	208	SH	Put	DFND	1	0	208	0
UNIQURE NV	SHS	N90064101	217	13,131	SH		DFND	1	0	13,131	0
UNITED THERAPEUTICS CORP	COM	91307C902	12,184	778	SH	Call	DFND	1	0	778	0
UNITED THERAPEUTICS CORP	COM	91307C952	12,529	800	SH	Put	DFND	1	0	800	0
UNITED THERAPEUTICS CORP	COM	91307C102	5,447	34,779	SH		DFND	1	0	34,779	0
VAPOR CORP DEL	COM	922099304	487	901,608	SH		DFND	1	0	901,608	0
VAPOR CORP DEL	UNIT	922099502	9,369	860,338	SH		DFND	1	0	860,338	0
VASCULAR SOLUTIONS INC	COM	92231M959	2,142	623	SH	Put	DFND	1	0	623	0
VASCULAR SOLUTIONS INC	COM	92231M109	1,053	30,626	SH		DFND	1	0	30,626	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	4,291	341	SH	Call	DFND	1	0	341	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	1,258	10,000	SH		DFND	1	0	10,000	0
VITAL THERAPIES INC	COM	92847R904	2,592	2,250	SH	Call	DFND	1	0	2,250	0
VTV THERAPEUTICS INC	CL A	918385105	952	139,747	SH		DFND	1	0	139,747	0
WAFERGEN BIO SYSTEMS INC.	COM	93041P308	1,014	1,381,074	SH		DFND	1	0	1,381,074	0
XOMA CORP	COM	98419J907	67	500	SH	Call	DFND	1	0	500	0
XTL BIOPHARMACEUTICALS	ADR	98386D208	1,668	1,111,962	SH		DFND	1	0	1,111,962	0
ZAFGEN INC	COM	98885E903	617	981	SH	Call	DFND	1	0	981	0
ZELTIQ AESTHETICS INC SHS CALL 30 01/15/2016	COM	98933Q908	1,740	610	SH	Call	DFND	1	0	610	0
ZOGENIX INC	COM	98978L904	22,378	15,182	SH	Call	DFND	1	0	15,182	0
ZOSANO PHARMA CORP.	COM	98979H103	287	128,900	SH		DFND	1	0	128,900	0