Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y959	8,831	1,546	SH	Put	DFND	1	0	1,546	0
ABBVIE INC	COM	00287Y909	79,774	13,966	SH	Call	DFND	1	0	13,966	0
ABEONA THERAPEUTICS INC	COM	00289Y107	855	334,108	SH		DFND	1	0	334,108	0
ACADIA PHARMACEUTICALS INC	COM	004225108	1,293	46,258	SH		DFND	1	0	46,258	0
ACADIA PHARMACEUTICALS INC	COM	004225958	3,895	1,393	SH	Put	DFND	1	0	1,393	0
ACADIA PHARMACEUTICALS INC	COM	004225908	5,145	1,840	SH	Call	DFND	1	0	1,840	0
ACCELERON PHARMA INC	COM	00434H108	1,320	50,000	SH		DFND	1	0	50,000	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q951	776	1,005	SH	Put	DFND	1	0	1,005	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q201	816	105,648	SH		DFND	1	0	105,648	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	1,774	2,298	SH	Call	DFND	1	0	2,298	0
ACORDA THERAPEUTICS INC 15JUN21 1.75%	NOTE	00484MAA4	8,580	9,600,000	PRN		DFND	1	0	0	0
ACURA PHARMACEUTICALS INC	COM	00509L802	1,836	648,884	SH		DFND	1	0	648,884	0
ADAMAS PHARMACEUTICALS INC	COM	00548A106	2,890	199,890	SH		DFND	1	0	199,890	0
ADURO BIOTECH INC	COM	00739L901	1,795	1,401	SH	Call	DFND	1	0	1,401	0
ADVAXIS INC	COM	007624958	485	537	SH	Put	DFND	1	0	537	0
ADVAXIS INC	COM	007624908	2,099	2,325	SH	Call	DFND	1	0	2,325	0
AETERNA ZENTARIS INC	COM	007975402	1,635	492,485	SH		DFND	1	0	492,485	0
AKARI THERAPEUTICS PLC	ADR	00972G108	606	40,705	SH		DFND	1	0	40,705	0
AKEBIA THERAPEUTICS INC	COM	00972D905	90	100	SH	Call	DFND	1	0	100	0
AKORN INC	COM	009728106	1,264	53,729	SH		DFND	1	0	53,729	0
AKORN INC	COM	009728906	1,918	815	SH	Call	DFND	1	0	815	0
AKORN INC	COM	009728956	2,809	1,194	SH	Put	DFND	1	0	1,194	0
ALCOBRA LTD	SHS	M2239P909	497	1,312	SH	Call	DFND	1	0	1,312	0
ALCOBRA LTD	SHS	M2239P109	761	200,868	SH		DFND	1	0	200,868	0
ALDEYRA THERAPEUTICS INC	COM	01438T106	172	41,096	SH		DFND	1	0	41,096	0
ALEXION PHARMACEUTICALS INC	COM	015351109	3,878	27,856	SH		DFND	1	0	27,856	0
ALEXION PHARMACEUTICALS INC	COM	015351959	4,761	342	SH	Put	DFND	1	0	342	0
ALKERMES PLC	SHS	G01767105	513	15,000	SH		DFND	1	0	15,000	0
ALLIQUA BIOMEDICAL INC	COM	019621900	40	483	SH	Call	DFND	1	0	483	0
ALLIQUA BIOMEDICAL INC	COM	019621200	1,613	1,967,208	SH		DFND	1	0	1,967,208	0
AMARIN CORP PLC	ADR	023111956	171	1,118	SH	Put	DFND	1	0	1,118	0
AMARIN CORP PLC	ADR	023111906	1,329	8,684	SH	Call	DFND	1	0	8,684	0
AMARIN CORP PLC	ADR	023111206	1,332	870,792	SH		DFND	1	0	870,792	0
AMGEN INC	COM	031162100	21,513	143,486	SH		DFND	1	0	143,486	0
AMGEN INC	COM	031162950	51,591	3,441	SH	Put	DFND	1	0	3,441	0
AMICUS THERAPEUTICS INC	COM	03152W109	501	59,324	SH		DFND	1	0	59,324	0
AMICUS THERAPEUTICS INC	COM	03152W909	2,032	2,405	SH	Call	DFND	1	0	2,405	0
AMICUS THERAPEUTICS INC	COM	03152W959	2,945	3,485	SH	Put	DFND	1	0	3,485	0
ANACOR PHARMACEUTICALS INC	COM	032420101	2,375	44,439	SH		DFND	1	0	44,439	0
ANACOR PHARMACEUTICALS INC	COM	032420901	6,489	1,214	SH	Call	DFND	1	0	1,214	0
ANTARES PHARMA INC	COM	036642906	35	399	SH	Call	DFND	1	0	399	0
ANTARES PHARMA INC	COM	036642106	675	775,212	SH		DFND	1	0	775,212	0
ANTHERA PHARMACEUTICALS INC	COM	03674U901	55	151	SH	Call	DFND	1	0	151	0
ANTHERA PHARMACEUTICALS INC	COM	03674U201	720	198,918	SH		DFND	1	0	198,918	0
ARALEZ PHARMACEUTICALS INC	COM	03852X900	133	375	SH	Call	DFND	1	0	375	0
ARALEZ PHARMACEUTICALS INC	COM	03852X100	839	236,364	SH		DFND	1	0	236,364	0
ARBUTUS BIOPHARMA CORP	COM	03879J900	260	630	SH	Call	DFND	1	0	630	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	4,945	1,197,338	SH		DFND	1	0	1,197,338	0
ARDELYX INC	COM	039697107	173	22,278	SH		DFND	1	0	22,278	0
ARIAD PHARMACEUTICALS INC	COM	04033A900	808	1,265	SH	Call	DFND	1	0	1,265	0
ARQULE INC	COM	04269E107	160	100,000	SH		DFND	1	0	100,000	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G907	55	106	SH	Call	DFND	1	0	106	0
AVALANCHE BIOTECHNOLOGIES INC	COM	05337G107	2,795	540,632	SH		DFND	1	0	540,632	0
AXOVANT SCIENCES LTD	COM	G0750W104	391	34,040	SH		DFND	1	0	34,040	0
BARCLAYS BK PLC IPATH S&P 500 MT ETN	ETN	06740C519	3,264	300,000	SH		DFND	1	0	300,000	0
BELLICUM PHARMACEUTICALS INC	COM	079481107	720	77,020	SH		DFND	1	0	77,020	0
BENITEC BIOPHARMA EQUITY WARRANTS EXP 14 AUG 2020	*W	082053117	100	99,555	SH		DFND	1	0	99,555	0
BENITEC BIOPHARMA LTD OPTIONS	ADR	082053307	739	422,101	SH		DFND	1	0	422,101	0
BIO BLAST PHARMA LTD	SHS	M20156101	2,824	1,133,937	SH		DFND	1	0	1,133,937	0
BIODEL INC	COM	09064M204	118	357,500	SH		DFND	1	0	357,500	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J906	295	912	SH	Call	DFND	1	0	912	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J106	1,796	555,969	SH		DFND	1	0	555,969	0
BIOGEN INC	COM	09062X103	9,652	37,077	SH		DFND	1	0	37,077	0
BIOGEN INC	COM	09062X953	27,386	1,052	SH	Put	DFND	1	0	1,052	0
BIOGEN INC	COM	09062X903	173,451	6,663	SH	Call	DFND	1	0	6,663	0
BIOMARIN PHARMACEUTICAL 0.75%	NOTE	09061GAE1	5,794	5,000,000	PRN		DFND	1	0	0	0
BIOPHARMX CORP	COM	09072X101	845	775,000	SH		DFND	1	0	775,000	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	535	29,624	SH		DFND	1	0	29,624	0
BLUEPRINT MEDICINES CORP	COM	09627Y909	5,415	3,000	SH	Call	DFND	1	0	3,000	0
BRAINSTORM CELL THERAPEUTICS INC	COM	10501E901	47	175	SH	Call	DFND	1	0	175	0
BRAINSTORM CELL THERAPEUTICS INC	COM	10501E201	1,317	493,191	SH		DFND	1	0	493,191	0
BRISTOL-MYERS SQUIBB CO	COM	110122908	1,686	264	SH	Call	DFND	1	0	264	0
CANCER GENETICS INC	COM	13739U104	231	81,300	SH		DFND	1	0	81,300	0
CAPNIA ORD SHS	COM	14066L105	637	530,524	SH		DFND	1	0	530,524	0
CAPRICOR THERAPEUTICS INC	COM	14070B101	513	202,083	SH		DFND	1	0	202,083	0
CARDICA INC	COM	14141R309	1,775	498,600	SH		DFND	1	0	498,600	0
CELATOR PHARMACEUTICALS INC	COM	15089R102	276	25,000	SH		DFND	1	0	25,000	0
CELGENE CORP	COM	151020904	3,748	313	SH	Call	DFND	1	0	313	0
CELLECTAR BIOSCIENCES EQUITY WARRANTS	*W	15117F120	47	65,362	SH		DFND	1	0	65,362	0
CELLECTAR BIOSCIENCES INC	COM	15117F302	242	71,313	SH		DFND	1	0	71,313	0
CELSION CORPORATION	COM	15117N404	27	18,789	SH		DFND	1	0	18,789	0
CEMPRA INC	COM	15130J959	1,177	672	SH	Put	DFND	1	0	672	0
CEMPRA INC	COM	15130J109	1,752	100,000	SH		DFND	1	0	100,000	0
CEMPRA INC	COM	15130J909	1,829	1,044	SH	Call	DFND	1	0	1,044	0
CERES INC.	COM	156773400	158	720,378	SH		DFND	1	0	720,378	0
CESCA THERAPEUTICS ORD SHS	COM	157131202	432	111,094	SH		DFND	1	0	111,094	0
CHAMPIONS ONCOLOGY INC	COM	15870P307	1,075	295,328	SH		DFND	1	0	295,328	0
CHIMERIX INC	COM	16934W106	274	53,620	SH		DFND	1	0	53,620	0
CIDARA THERAPEUTICS INC	COM	171757107	512	40,277	SH		DFND	1	0	40,277	0
CLOVIS ONCOLOGY INC	COM	189464950	192	100	SH	Put	DFND	1	0	100	0
CLOVIS ONCOLOGY INC	COM	189464100	256	13,326	SH		DFND	1	0	13,326	0
CLOVIS ONCOLOGY INC	COM	189464900	3,575	1,862	SH	Call	DFND	1	0	1,862	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	1,490	82,100	SH		DFND	1	0	82,100	0
COMBIMATRIX EQUITY WARRANTS	*W	20009T147	610	911,041	SH		DFND	1	0	911,041	0
CYCLACEL PHARMACEUTICALS INC	COM	23254L306	628	1,632,259	SH		DFND	1	0	1,632,259	0
CYMABAY THERAPEUTICS INC	COM	23257D103	91	67,534	SH		DFND	1	0	67,534	0
CYNAPSUS THERAPEUTICS INC	COM	23257Y859	792	66,522	SH		DFND	1	0	66,522	0
CYTOKINETICS INC	COM	23282W905	752	1,066	SH	Call	DFND	1	0	1,066	0
CYTORI THERAPEUTICS INC	COM	23283K105	14,310	7,305,690	SH		DFND	1	0	7,305,690	0
CYTRX CORP INC	COM	232828909	46	170	SH	Call	DFND	1	0	170	0
DBV TECHNOLOGIES S A	COM	23306J101	2,279	70,000	SH		DFND	1	0	70,000	0
DEPOMED INC	COM	249908104	1,477	106,057	SH		DFND	1	0	106,057	0
DEPOMED INC	COM	249908904	5,862	4,208	SH	Call	DFND	1	0	4,208	0
DERMIRA INC	COM	24983L954	207	100	SH	Put	DFND	1	0	100	0
DERMIRA INC	COM	24983L104	2,535	122,600	SH		DFND	1	0	122,600	0
DISCOVERY LABORATORIES INC	COM	254668502	934	566,352	SH		DFND	1	0	566,352	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	1,164	605	SH	Put	DFND	1	0	605	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	2,501	1,300	SH	Call	DFND	1	0	1,300	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	4,233	220,000	SH		DFND	1	0	220,000	0
EAGLE PHARMACEUTICALS INC	COM	269796958	405	100	SH	Put	DFND	1	0	100	0
EAGLE PHARMACEUTICALS INC	COM	269796108	405	10,000	SH		DFND	1	0	10,000	0
EAGLE PHARMACEUTICALS INC	COM	269796908	4,050	1,000	SH	Call	DFND	1	0	1,000	0
EDAP TMS SA	ADR	268311957	409	1,018	SH	Put	DFND	1	0	1,018	0
EDWARDS LIFESCIENCES CORP	COM	28176E958	19,415	2,201	SH	Put	DFND	1	0	2,201	0
EDWARDS LIFESCIENCES CORP	COM	28176E908	21,850	2,477	SH	Call	DFND	1	0	2,477	0
EIGER BIOPHARMACEUTICALS INC	COM	28249U105	4,354	259,643	SH		DFND	1	0	259,643	0
ELEVEN BIOTHERAPEUTICS INC	COM	286221106	387	1,213,984	SH		DFND	1	0	1,213,984	0
ELI LILLY & CO	COM	532457958	34,586	4,803	SH	Put	DFND	1	0	4,803	0
ELI LILLY & CO	COM	532457908	208,555	28,962	SH	Call	DFND	1	0	28,962	0
ENDO INTERNATIONAL PLC	SHS	G30401106	1,408	50,000	SH		DFND	1	0	50,000	0
EXELIXIS INC	COM	30161Q904	713	1,783	SH	Call	DFND	1	0	1,783	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G108	2,838	41,311	SH		DFND	1	0	41,311	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G958	7,309	1,064	SH	Put	DFND	1	0	1,064	0
EYEGATE PHARMACEUTICALS EQUITY WARRANTS	*W	30233M115	49	65,393	SH		DFND	1	0	65,393	0
FIBROGEN INC.	COM	31572Q808	2,323	109,100	SH		DFND	1	0	109,100	0
FLEXION THERAPEUTICS INC.	COM	33938J106	426	46,355	SH		DFND	1	0	46,355	0
FLUIDIGM INC	COM	34385P108	1,126	139,506	SH		DFND	1	0	139,506	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	1,698	260,400	SH		DFND	1	0	260,400	0
FORWARD PHARMA A/S	ADR	34986J105	1,305	76,785	SH		DFND	1	0	76,785	0
GALECTIN THERAPEUTICS INC.	COM	363225202	1,534	1,072,765	SH		DFND	1	0	1,072,765	0
GALENA BIOPHARMA INC	COM	363256958	34	235	SH	Put	DFND	1	0	235	0
GILEAD SCIENCES INC	COM	375558953	459	50	SH	Put	DFND	1	0	50	0
GILEAD SCIENCES INC	COM	375558903	77,530	8,440	SH	Call	DFND	1	0	8,440	0
GLOBAL BLOOD THERAPEUTICS INC	COM	37890U108	2,173	137,000	SH		DFND	1	0	137,000	0
GLOBAL BLOOD THERAPEUTICS INC	COM	37890U908	8,924	5,627	SH	Call	DFND	1	0	5,627	0
GW PHARMACEUTICALS PLC	ADS	36197T103	1,775	24,603	SH		DFND	1	0	24,603	0
GW PHARMACEUTICALS PLC	ADS	36197T953	6,551	908	SH	Put	DFND	1	0	908	0
HALOZYME THERAPEUTICS INC	COM	40637H109	568	60,000	SH		DFND	1	0	60,000	0
HALOZYME THERAPEUTICS INC	COM	40637H909	1,921	2,029	SH	Call	DFND	1	0	2,029	0
HCA HOLDINGS INC	COM	40412C901	53,058	6,798	SH	Call	DFND	1	0	6,798	0
HEAT BIOLOGICS INC	COM	42237K102	626	902,007	SH		DFND	1	0	902,007	0
HERON THERAPEUTICS INC	COM	427746902	239	126	SH	Call	DFND	1	0	126	0
HISTOGENICS INC.	COM	43358V109	345	150,630	SH		DFND	1	0	150,630	0
HORIZON PHARMA PLC	SHS	G4617B955	646	390	SH	Put	DFND	1	0	390	0
HORIZON PHARMA PLC	SHS	G4617B905	1,505	908	SH	Call	DFND	1	0	908	0
IGNYTA INC	COM	451731103	846	125,000	SH		DFND	1	0	125,000	0
IMMUNOCELLULAR THERAPEUTICS INC	COM	452536105	1,279	4,411,371	SH		DFND	1	0	4,411,371	0
IMMUNOMEDICS 15FEB20 4.75PCT	NOTE	452907108	182,240	2,680,000	PRN		DFND	1	0	0	0
INOTEK PHARMACEUTICALS CORP	COM	45780V102	862	116,454	SH		DFND	1	0	116,454	0
INSMED INC	COM	457669907	375	296	SH	Call	DFND	1	0	296	0
INSMED INC	COM	457669307	454	35,867	SH		DFND	1	0	35,867	0
INSMED INC	COM	457669957	977	771	SH	Put	DFND	1	0	771	0
INSPIREMD INC	COM	45779A507	399	790,538	SH		DFND	1	0	790,538	0
INTEC PHARMA LTD JERUSALEM	SHS	M53644106	2,949	714,062	SH		DFND	1	0	714,062	0
INTELLIPHARMACEUTICS INTERNATIONAL INC	COM	458173951	25	122	SH	Put	DFND	1	0	122	0
INTERCEPT PHARMACEUTICALS INC	COM	45845P958	925	72	SH	Put	DFND	1	0	72	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	2,168	78,000	SH		DFND	1	0	78,000	0
INTRA CELLULAR THERAPIES INC	COM	46116X901	2,836	1,020	SH	Call	DFND	1	0	1,020	0
INTRA CELLULAR THERAPIES INC	COM	46116X951	3,358	1,208	SH	Put	DFND	1	0	1,208	0
INTREXON CORP	COM	46122T952	3,436	1,014	SH	Put	DFND	1	0	1,014	0
INTREXON CORP	COM	46122T102	3,793	111,907	SH		DFND	1	0	111,907	0
INVIVO THERAPEUTICS HOLDINGS CORP	COM	46186M909	1,902	2,725	SH	Call	DFND	1	0	2,725	0
INVIVO THERAPEUTICS HOLDINGS CORP	COM	46186M209	3,787	542,500	SH		DFND	1	0	542,500	0
IONIS PHARMACEUTICALS INC	COM	462222100	284	7,002	SH		DFND	1	0	7,002	0
IONIS PHARMACEUTICALS INC	COM	462222950	753	186	SH	Put	DFND	1	0	186	0
IPATH S&P 500 MT	ETN	06740C519	521	479	SH	Call	DFND	1	0	479	0
ISHARES RUSSELL 2000 ETF	ETF	464287955	162,342	17,673	SH	Put	DFND	1	0	17,673	0
JOHNSON & JOHNSON	COM	478160954	22,300	2,061	SH	Put	DFND	1	0	2,061	0
JOHNSON & JOHNSON	COM	478160904	68,967	6,374	SH	Call	DFND	1	0	6,374	0
JUNO THERAPEUTICS INC	COM	48205A909	255	67	SH	Call	DFND	1	0	67	0
KITE PHARMA INC	COM	49803L909	1,632	605	SH	Call	DFND	1	0	605	0
KITOV PHARMACEUTICALS HOLDINGS EQUITY WARRANTS	*W	49803V115	126	114,720	SH		DFND	1	0	114,720	0
LA JOLLA PHARMACEUTICAL CO	COM	503459604	2,346	112,184	SH		DFND	1	0	112,184	0
LEXICON PHARMACEUTICALS INC	COM	528872902	4,890	4,092	SH	Call	DFND	1	0	4,092	0
LINKEDIN CORP	COM	53578A908	6,621	579	SH	Call	DFND	1	0	579	0
LION BIOTECHNOLOGIES INC	COM	53619R102	2,094	412,246	SH		DFND	1	0	412,246	0
LIPOCINE INC	COM	53630X904	355	350	SH	Call	DFND	1	0	350	0
LIPOCINE INC	COM	53630X104	1,534	151,086	SH		DFND	1	0	151,086	0
LPATH INC	COM	548910306	206	1,106,870	SH		DFND	1	0	1,106,870	0
MANNKIND CORP	COM	56400P951	176	1,096	SH	Put	DFND	1	0	1,096	0
MANNKIND CORP	COM	56400P901	966	6,000	SH	Call	DFND	1	0	6,000	0
MAST THERAPEUTICS INC	COM	576314108	1,062	3,877,356	SH		DFND	1	0	3,877,356	0
MEDGENICS EQUITY WARRANTS EXP 13 FEB 2018	*W	58436Q112	1,173	1,564,370	SH		DFND	1	0	1,564,370	0
MEDICINES CO	COM	584688905	30,185	9,501	SH	Call	DFND	1	0	9,501	0
MEDICINES CO 01JUN17 1.375%	DBCV	584688AC9	1,913	1,500,000	PRN		DFND	1	0	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	1,207	56,400	SH		DFND	1	0	56,400	0
MOMENTA PHARMACEUTICALS INC	COM	60877T100	2,589	280,225	SH		DFND	1	0	280,225	0
MYLAN N.V.	SHS	N59465909	1,409	304	SH	Call	DFND	1	0	304	0
NANOSPHERE ORD SHS	COM	63009F204	243	308,147	SH		DFND	1	0	308,147	0
NATERA INC	COM	632307104	659	69,272	SH		DFND	1	0	69,272	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	1,444	365	SH	Call	DFND	1	0	365	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	2,769	70,000	SH		DFND	1	0	70,000	0
NEUROMETRIX EQUITY WARRANTS EXPIRING 29 MAY 2020	*W	641255153	1,252	3,130,468	SH		DFND	1	0	3,130,468	0
NEUROMETRIX INC	COM	641255500	154	84,263	SH		DFND	1	0	84,263	0
NEWLINK GENETICS CORP	COM	651511957	420	231	SH	Put	DFND	1	0	231	0
NEWLINK GENETICS CORP	COM	651511107	2,320	127,459	SH		DFND	1	0	127,459	0
NEWLINK GENETICS CORP	COM	651511907	3,374	1,854	SH	Call	DFND	1	0	1,854	0
NIVALIS THERAPEUTICS INC	COM	65481J109	2,761	662,058	SH		DFND	1	0	662,058	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P950	119	813	SH	Put	DFND	1	0	813	0
NORTHWEST BIOTHERAPEUTICS INC	COM	66737P600	4,844	3,317,519	SH		DFND	1	0	3,317,519	0
NOVAVAX INC	COM	670002954	454	880	SH	Put	DFND	1	0	880	0
NOVAVAX INC	COM	670002904	529	1,025	SH	Call	DFND	1	0	1,025	0
NXSTAGE MEDICAL INC	COM	67072V953	150	100	SH	Put	DFND	1	0	100	0
OASMIA PHARMACEUTICAL AB	ADR	67421W109	2,021	477,836	SH		DFND	1	0	477,836	0
OCERA THERAPEUTICS INC	COM	67552A108	1,173	399,035	SH		DFND	1	0	399,035	0
OMEROS CORP	COM	682143902	637	415	SH	Call	DFND	1	0	415	0
ONCOSEC MEDICAL INC	COM	68234L207	2,834	1,111,348	SH		DFND	1	0	1,111,348	0
ONCOTHYREON INC	COM	682324108	939	739,004	SH		DFND	1	0	739,004	0
OPEXA THERAPEUTICS EQUITY WARRANTS	*W	68372T129	2	34,097	SH		DFND	1	0	34,097	0
OPKO HEALTH INC	COM	68375N953	1,138	1,095	SH	Put	DFND	1	0	1,095	0
OPKO HEALTH INC	COM	68375N103	1,164	112,011	SH		DFND	1	0	112,011	0
OTONOMY INC	COM	68906L105	746	50,000	SH		DFND	1	0	50,000	0
PARATEK PHARMACEUTICALS INC	COM	699374902	282	186	SH	Call	DFND	1	0	186	0
PARATEK PHARMACEUTICALS INC	COM	699374302	2,918	192,322	SH		DFND	1	0	192,322	0
PERSEON EQUITY WARRANTS	*W	715270112	4	1,887,892	SH		DFND	1	0	1,887,892	0
PIERIS PHARMACEUTICALS INC	COM	720795103	333	175,000	SH		DFND	1	0	175,000	0
PLURISTEM THERAPEUTICS INC	COM	72940R102	404	251,020	SH		DFND	1	0	251,020	0
PORTOLA PHARMACEUTICALS INC	COM	737010908	6,571	3,221	SH	Call	DFND	1	0	3,221	0
PROGENICS PHARMACEUTICALS INC	COM	743187956	57	130	SH	Put	DFND	1	0	130	0
PROGENICS PHARMACEUTICALS INC	COM	743187906	603	1,384	SH	Call	DFND	1	0	1,384	0
PROGENICS PHARMACEUTICALS INC	COM	743187106	1,505	345,197	SH		DFND	1	0	345,197	0
PROQR THERAPEUTICS N V	SHS	N71542109	732	149,934	SH		DFND	1	0	149,934	0
PROTHENA CORP PLC	SHS	G72800108	1,646	40,000	SH		DFND	1	0	40,000	0
PROVECTUS BIOPHARMACEUTICALS	COM	74373P108	275	726,200	SH		DFND	1	0	726,200	0
PSIVIDA CORP	COM	74440J101	787	293,585	SH		DFND	1	0	293,585	0
PTC THERAPEUTICS INC	COM	69366J900	644	1,000	SH	Call	DFND	1	0	1,000	0
QUEST RESOURCE HOLDING ORD SHS	COM	74836W104	895	2,131,914	SH		DFND	1	0	2,131,914	0
RADIUS HEALTH INC	COM	750469207	2,044	65,000	SH		DFND	1	0	65,000	0
REDHILL BIOPHARMA LTD	ADS	757468103	1,917	156,523	SH		DFND	1	0	156,523	0
REGENERON PHARMACEUTICALS INC	COM	75886F907	3,713	103	SH	Call	DFND	1	0	103	0
REGENERON PHARMACEUTICALS INC	COM	75886F107	14,067	39,027	SH		DFND	1	0	39,027	0
REGENERON PHARMACEUTICALS INC	COM	75886F957	21,194	588	SH	Put	DFND	1	0	588	0
REGENXBIO INC	COM	75901B107	3,244	300,329	SH		DFND	1	0	300,329	0
REGULUS THERAPEUTIC INC	COM	75915K951	398	574	SH	Put	DFND	1	0	574	0
REGULUS THERAPEUTIC INC	COM	75915K101	970	140,000	SH		DFND	1	0	140,000	0
REGULUS THERAPEUTIC INC	COM	75915K901	8,110	11,703	SH	Call	DFND	1	0	11,703	0
RELYPSA INC	COM	759531956	562	415	SH	Put	DFND	1	0	415	0
RELYPSA INC	COM	759531906	641	473	SH	Call	DFND	1	0	473	0
RELYPSA INC	COM	759531106	1,665	122,905	SH		DFND	1	0	122,905	0
RENNOVA HEALTH EQUITY WARRANTS	*W	759757115	161	3,225,806	SH		DFND	1	0	3,225,806	0
RENNOVA HEALTH INC	COM	759757107	23	30,761	SH		DFND	1	0	30,761	0
RETROPHIN INC	COM	761299106	2,142	156,774	SH		DFND	1	0	156,774	0
RETROPHIN INC	COM	761299906	4,941	3,617	SH	Call	DFND	1	0	3,617	0
RETROPHIN INC	COM	761299956	8,539	6,251	SH	Put	DFND	1	0	6,251	0
REVANCE THERAPEUTICS INC	COM	761330909	527	302	SH	Call	DFND	1	0	302	0
REXAHN PHARMACEUTICALS INC	COM	761640101	4,361	13,212,254	SH		DFND	1	0	13,212,254	0
RICEBRAN TECHNOLOGIES INC	COM	762831204	1,140	1,017,458	SH		DFND	1	0	1,017,458	0
SAGE THERAPEUTICS INC	COM	78667J908	939	293	SH	Call	DFND	1	0	293	0
SAGE THERAPEUTICS INC	COM	78667J108	3,206	100,000	SH		DFND	1	0	100,000	0
SANGAMO BIOSCIENCES INC	COM	800677106	814	134,500	SH		DFND	1	0	134,500	0
SANGAMO BIOSCIENCES INC	COM	800677906	1,818	3,005	SH	Call	DFND	1	0	3,005	0
SAREPTA THERAPEUTICS INC	COM	803607900	2,329	1,193	SH	Call	DFND	1	0	1,193	0
SAREPTA THERAPEUTICS INC	COM	803607100	9,876	505,937	SH		DFND	1	0	505,937	0
SAREPTA THERAPEUTICS INC	COM	803607950	17,224	8,824	SH	Put	DFND	1	0	8,824	0
SENSEONICS HOLDINGS INC	COM	81727U105	440	153,900	SH		DFND	1	0	153,900	0
SERES THERAPEUTICS INC	COM	81750R102	1,840	69,287	SH		DFND	1	0	69,287	0
SKYLINE MEDICAL INC	COM	83084T309	345	2,001,348	SH		DFND	1	0	2,001,348	0
SORRENTO THERAPEUTICS INC	COM	83587F202	2,043	379,800	SH		DFND	1	0	379,800	0
SPDR S&P 500 ETF TRUST	UNIT	78462F953	188,635	10,176	SH	Put	DFND	1	0	10,176	0
SPDR S&P 500 ETF TRUST	UNIT	78462F103	22,385	108,899	SH		DFND	1	0	108,899	0
SPDR S&P BIOTECH ETF	S&P	78464A950	27,571	5,337	SH	Put	DFND	1	0	5,337	0
SPECTRANETICS CORP	COM	84760C907	405	279	SH	Call	DFND	1	0	279	0
STRATA SKIN SCIENCES INC	COM	86272A107	542	573,077	SH		DFND	1	0	573,077	0
SUPERCONDUCTOR TECHNOLOGIES	COM	867931404	523	2,734,500	SH		DFND	1	0	2,734,500	0
SYNERGY PHARMACEUTICALS EQUITY WARRANTS	*W	871639118	157	285,414	SH		DFND	1	0	285,414	0
SYNERGY PHARMACEUTICALS INC	COM	871639308	1,083	392,273	SH		DFND	1	0	392,273	0
SYNERGY PHARMACEUTICALS INC	COM	871639908	2,685	9,727	SH	Call	DFND	1	0	9,727	0
T2 BIOSYSTEMS INC	COM	89853L104	1,430	145,000	SH		DFND	1	0	145,000	0
TENAX THERAPEUTICS INC	COM	88032L100	5,681	2,771,109	SH		DFND	1	0	2,771,109	0
TENAX THERAPEUTICS INC	COM	88032L900	35	173	SH	Call	DFND	1	0	173	0
THERAPEUTICSMD INC	COM	88338N957	259	404	SH	Put	DFND	1	0	404	0
THERAPEUTICSMD INC	COM	88338N907	327	511	SH	Call	DFND	1	0	511	0
THERAPEUTICSMD INC	COM	88338N107	835	130,400	SH		DFND	1	0	130,400	0
THRESHOLD PHARMACEUTICALS INC	COM	885807206	385	837,904	SH		DFND	1	0	837,904	0
TOBIRA THERAPEUTICS INC	COM	88883P101	818	100,000	SH		DFND	1	0	100,000	0
TOKAI PHARMACEUTICALS INC	COM	88907J107	4,556	812,200	SH		DFND	1	0	812,200	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260901	36	148	SH	Call	DFND	1	0	148	0
TONIX PHARMACEUTICALS HOLDING CORP	COM	890260201	928	385,248	SH		DFND	1	0	385,248	0
TRANSENTERIX INC	COM	89366M951	205	482	SH	Put	DFND	1	0	482	0
TRANSENTERIX INC	COM	89366M901	2,514	5,916	SH	Call	DFND	1	0	5,916	0
TRILLIUM THERAPEUTICS INC	COM	89620X506	131	14,137	SH		DFND	1	0	14,137	0
TROVAGENE INC	COM	897238309	395	85,000	SH		DFND	1	0	85,000	0
UNITED THERAPEUTICS CORP	COM	91307C902	8,357	750	SH	Call	DFND	1	0	750	0
VALEANT PHARMACEUTICALS INTERNATIONAL INC	COM	91911K902	392	149	SH	Call	DFND	1	0	149	0
VERTEX PHARMACEUTICALS INC	COM	92532F950	262	33	SH	Put	DFND	1	0	33	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	1,854	23,320	SH		DFND	1	0	23,320	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	4,372	550	SH	Call	DFND	1	0	550	0
VTV THERAPEUTICS INC	CL A	918385105	721	139,747	SH		DFND	1	0	139,747	0
WAFERGEN BIO SYSTEMS INC	COM	93041P308	765	1,195,470	SH		DFND	1	0	1,195,470	0
XTL BIOPHARMACEUTICALS LTD	ADR	98386D208	1,073	1,040,194	SH		DFND	1	0	1,040,194	0
ZAFGEN INC	COM	98885E903	966	1,446	SH	Call	DFND	1	0	1,446	0
ZOGENIX INC	COM	98978L204	2,351	254,424	SH		DFND	1	0	254,424	0
ZOGENIX INC	COM	98978L904	4,286	4,639	SH	Call	DFND	1	0	4,639	0
ZOSANO PHARMA INC	COM	98979H103	296	128,600	SH		DFND	1	0	128,600	0