| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABS | COM | 002824900 | 2,182 | 555 | SH | Call | DFND | 1 | 0 | 555 | 0 |
| ABBOTT LABS | COM | 002824100 | 10,405 | 264,700 | SH | | DFND | 1 | 0 | 264,700 | 0 |
| ABBOTT LABS | COM | 002824950 | 19,655 | 5,000 | SH | Put | DFND | 1 | 0 | 5,000 | 0 |
| ABBVIE INC | COM | 00287Y959 | 14,530 | 2,347 | SH | Put | DFND | 1 | 0 | 2,347 | 0 |
| ABBVIE INC | COM | 00287Y909 | 111,481 | 18,007 | SH | Call | DFND | 1 | 0 | 18,007 | 0 |
| ABEONA THERAPEUTICS ORD SHS | COM | 00289Y107 | 637 | 270,000 | SH | | DFND | 1 | 0 | 270,000 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225958 | 1,607 | 495 | SH | Put | DFND | 1 | 0 | 495 | 0 |
| ACADIA PHARMACEUTICALS INC | COM | 004225908 | 15,172 | 4,674 | SH | Call | DFND | 1 | 0 | 4,674 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q951 | 780 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 2,985 | 3,827 | SH | Call | DFND | 1 | 0 | 3,827 | 0 |
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 292 | 15,812 | SH | | DFND | 1 | 0 | 15,812 | 0 |
| ACORDA THERAPEUTICS INC | COM | 00484M956 | 255 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| ACORDA THERAPEUTICS INC 1.75% | NOTE | 00484MAA4 | 8,388 | 9,600,000 | PRN | | DFND | 1 | 0 | 9,600,000 | 0 |
| ACURA PHARMACEUTICALS INC | COM | 00509L802 | 959 | 518,444 | SH | | DFND | 1 | 0 | 518,444 | 0 |
| ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 1,478 | 97,600 | SH | | DFND | 1 | 0 | 97,600 | 0 |
| ADMA BIOLOGICS INC | COM | 000899104 | 595 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| ADURO BIOTECH INC | COM | 00739L901 | 1,495 | 1,322 | SH | Call | DFND | 1 | 0 | 1,322 | 0 |
| ADVAXIS INC | COM | 007624958 | 113 | 140 | SH | Put | DFND | 1 | 0 | 140 | 0 |
| ADVAXIS INC | COM | 007624208 | 113 | 14,000 | SH | | DFND | 1 | 0 | 14,000 | 0 |
| ADVERUM BIOTECHNOLOGIES INC. | COM | 00773U108 | 2,465 | 779,926 | SH | | DFND | 1 | 0 | 779,926 | 0 |
| AERIE PHARMACEUTICALS INC | COM | 00771V908 | 1,186 | 674 | SH | Call | DFND | 1 | 0 | 674 | 0 |
| AETERNA ZENTARIS INC | COM | 007975402 | 867 | 265,803 | SH | | DFND | 1 | 0 | 265,803 | 0 |
| AKARI THERAPEUTICS PLC | ADR | 00972G108 | 235 | 17,428 | SH | | DFND | 1 | 0 | 17,428 | 0 |
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 75 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| ALCOBRA LTD | SHS | M2239P109 | 82 | 18,317 | SH | | DFND | 1 | 0 | 18,317 | 0 |
| ALCOBRA LTD | SHS | M2239P959 | 184 | 409 | SH | Put | DFND | 1 | 0 | 409 | 0 |
| ALCOBRA LTD | SHS | M2239P909 | 2,006 | 4,467 | SH | Call | DFND | 1 | 0 | 4,467 | 0 |
| ALKERMES PLC | SHS | G01767905 | 7,930 | 1,335 | SH | Call | DFND | 1 | 0 | 1,335 | 0 |
| ALLIQUA BIOMEDICAL INC | COM | 019621900 | 54 | 483 | SH | Call | DFND | 1 | 0 | 483 | 0 |
| ALLIQUA BIOMEDICAL INC | COM | 019621200 | 1,680 | 1,500,000 | SH | | DFND | 1 | 0 | 1,500,000 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q957 | 3,363 | 606 | SH | Put | DFND | 1 | 0 | 606 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 5,477 | 987 | SH | Call | DFND | 1 | 0 | 987 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111956 | 241 | 1,118 | SH | Put | DFND | 1 | 0 | 1,118 | 0 |
| AMARIN CORPORATION PLC | ADR | 023111906 | 2,033 | 9,411 | SH | Call | DFND | 1 | 0 | 9,411 | 0 |
| AMGEN INC | COM | 031162100 | 23,444 | 154,082 | SH | | DFND | 1 | 0 | 154,082 | 0 |
| AMGEN INC | COM | 031162950 | 59,978 | 3,942 | SH | Put | DFND | 1 | 0 | 3,942 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 687 | 125,912 | SH | | DFND | 1 | 0 | 125,912 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W959 | 1,220 | 2,234 | SH | Put | DFND | 1 | 0 | 2,234 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W909 | 4,364 | 7,992 | SH | Call | DFND | 1 | 0 | 7,992 | 0 |
| AMPLIPHI BIOSCIENCES CORP | COM | 03211P202 | 951 | 613,782 | SH | | DFND | 1 | 0 | 613,782 | 0 |
| ANTARES PHARMA INC | COM | 036642106 | 445 | 424,100 | SH | | DFND | 1 | 0 | 424,100 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U201 | 309 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U901 | 518 | 1,677 | SH | Call | DFND | 1 | 0 | 1,677 | 0 |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X900 | 136 | 413 | SH | Call | DFND | 1 | 0 | 413 | 0 |
| ARALEZ PHARMACEUTICALS INC | COM | 03852X100 | 754 | 228,364 | SH | | DFND | 1 | 0 | 228,364 | 0 |
| ARBUTUS BIOPHARMA CORP | COM | 03879J900 | 233 | 669 | SH | Call | DFND | 1 | 0 | 669 | 0 |
| ARBUTUS BIOPHARMA CORP | COM | 03879J100 | 4,093 | 1,176,031 | SH | | DFND | 1 | 0 | 1,176,031 | 0 |
| ASSEMBLY BIOSCIENCES INC | COM | 045396108 | 502 | 90,362 | SH | | DFND | 1 | 0 | 90,362 | 0 |
| ASTERIAS BIOTHERAPEUTICS INC | COM | 04624N107 | 741 | 308,909 | SH | | DFND | 1 | 0 | 308,909 | 0 |
| ATHERSYS INC SHS | COM | 04744L956 | 49 | 225 | SH | Put | DFND | 1 | 0 | 225 | 0 |
| ATHERSYS INC SHS | COM | 04744L106 | 199 | 91,746 | SH | | DFND | 1 | 0 | 91,746 | 0 |
| AXOVANT SCIENCES LTD | COM | G0750W104 | 2,440 | 190,000 | SH | | DFND | 1 | 0 | 190,000 | 0 |
| BARCLAYS BANK IPATH S&P 500 MT | ETN | 06740C519 | 2,805 | 260,000 | SH | | DFND | 1 | 0 | 260,000 | 0 |
| BENITEC BIOPHARMA LTD | ADR | 082053307 | 438 | 345,576 | SH | | DFND | 1 | 0 | 345,576 | 0 |
| BENITEC BIOPHARMA LTD | *W | 082053117 | 24 | 98,146 | SH | | DFND | 1 | 0 | 98,146 | 0 |
| BIO BLAST PHARMA LTD | SHS | M20156101 | 1,328 | 830,253 | SH | | DFND | 1 | 0 | 830,253 | 0 |
| BIO PATH HOLDINGS INC | COM | 09057N102 | 5,947 | 2,988,295 | SH | | DFND | 1 | 0 | 2,988,295 | 0 |
| BIODELIVERY SCIENCES INTERNATIONAL INC | COM | 09060J906 | 384 | 1,626 | SH | Call | DFND | 1 | 0 | 1,626 | 0 |
| BIODELIVERY SCIENCES INTERNATIONAL INC | COM | 09060J106 | 1,854 | 785,799 | SH | | DFND | 1 | 0 | 785,799 | 0 |
| BIOGEN INC | COM | 09062X953 | 2,418 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| BIOGEN INC | COM | 09062X103 | 2,418 | 10,000 | SH | | DFND | 1 | 0 | 10,000 | 0 |
| BIOGEN INC | COM | 09062X903 | 45,124 | 1,866 | SH | Call | DFND | 1 | 0 | 1,866 | 0 |
| BIOPHARMX CORP | COM | 09072X101 | 622 | 957,000 | SH | | DFND | 1 | 0 | 957,000 | 0 |
| BRAINSTORM CELL THERAPEUTICS INC | COM | 10501E201 | 1,149 | 476,719 | SH | | DFND | 1 | 0 | 476,719 | 0 |
| CANCER GENETICS INC | COM | 13739U104 | 397 | 199,580 | SH | | DFND | 1 | 0 | 199,580 | 0 |
| CAPNIA INC. | COM | 14066L105 | 581 | 501,240 | SH | | DFND | 1 | 0 | 501,240 | 0 |
| CAPRICOR THERAPEUTICS INC | COM | 14070B101 | 719 | 182,083 | SH | | DFND | 1 | 0 | 182,083 | 0 |
| CAPSTONE TURBINE CORP | COM | 14067D409 | 1,845 | 1,336,901 | SH | | DFND | 1 | 0 | 1,336,901 | 0 |
| CASCADIAN THERAPEUTICS INC | COM | 14740B101 | 815 | 864,402 | SH | | DFND | 1 | 0 | 864,402 | 0 |
| CEL SCI CORP | COM | 150837508 | 3,755 | 8,163,816 | SH | | DFND | 1 | 0 | 8,163,816 | 0 |
| CELATOR PHARMACEUTICALS INC | COM | 15089R102 | 800 | 26,500 | SH | | DFND | 1 | 0 | 26,500 | 0 |
| CELGENE CORP | COM | 151020954 | 759 | 77 | SH | Put | DFND | 1 | 0 | 77 | 0 |
| CELGENE CORP | COM | 151020904 | 6,855 | 695 | SH | Call | DFND | 1 | 0 | 695 | 0 |
| CELLECTAR BIOSCIENCES INC | *W | 15117F120 | 219 | 230,013 | SH | | DFND | 1 | 0 | 230,013 | 0 |
| CELSION CORP. | COM | 15117N404 | 1,930 | 1,519,365 | SH | | DFND | 1 | 0 | 1,519,365 | 0 |
| CEMPRA INC | COM | 15130J109 | 1,056 | 64,065 | SH | | DFND | 1 | 0 | 64,065 | 0 |
| CEMPRA INC | COM | 15130J909 | 2,535 | 1,537 | SH | Call | DFND | 1 | 0 | 1,537 | 0 |
| CEMPRA INC | COM | 15130J959 | 3,859 | 2,340 | SH | Put | DFND | 1 | 0 | 2,340 | 0 |
| CHAMPIONS ONCOLOGY INC | COM | 15870P307 | 1,175 | 546,728 | SH | | DFND | 1 | 0 | 546,728 | 0 |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 209 | 20,277 | SH | | DFND | 1 | 0 | 20,277 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464950 | 141 | 103 | SH | Put | DFND | 1 | 0 | 103 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 821 | 59,836 | SH | | DFND | 1 | 0 | 59,836 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464900 | 2,231 | 1,626 | SH | Call | DFND | 1 | 0 | 1,626 | 0 |
| COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 1,202 | 101,410 | SH | | DFND | 1 | 0 | 101,410 | 0 |
| COMBIMATRIX CORP. | COM | 20009T501 | 41 | 14,391 | SH | | DFND | 1 | 0 | 14,391 | 0 |
| COMBIMATRIX CORP. | *W | 20009T147 | 573 | 855,171 | SH | | DFND | 1 | 0 | 855,171 | 0 |
| CORSICANTO LTD 3.5% | NOTE | 220480AB3 | 7,877 | 7,756,000 | PRN | | DFND | 1 | 0 | 7,756,000 | 0 |
| CYNAPSUS THERAPEUTICS INC | COM | 23257Y859 | 305 | 18,194 | SH | | DFND | 1 | 0 | 18,194 | 0 |
| CYTORI THERAPEUTICS INC | *W | 23283K121 | 793 | 1,004,065 | SH | | DFND | 1 | 0 | 1,004,065 | 0 |
| CYTORI THERAPEUTICS INC | COM | 23283K204 | 4,110 | 1,966,708 | SH | | DFND | 1 | 0 | 1,966,708 | 0 |
| DEPOMED INC | COM | 249908904 | 1,546 | 788 | SH | Call | DFND | 1 | 0 | 788 | 0 |
| DERMIRA INC | COM | 24983L104 | 781 | 26,693 | SH | | DFND | 1 | 0 | 26,693 | 0 |
| DERMIRA INC | COM | 24983L954 | 845 | 289 | SH | Put | DFND | 1 | 0 | 289 | 0 |
| DERMIRA INC | COM | 24983L904 | 1,205 | 412 | SH | Call | DFND | 1 | 0 | 412 | 0 |
| DEXCOM INC | COM | 252131907 | 9,361 | 1,180 | SH | Call | DFND | 1 | 0 | 1,180 | 0 |
| DEXCOM INC | COM | 252131957 | 33,430 | 4,214 | SH | Put | DFND | 1 | 0 | 4,214 | 0 |
| DEXTERA SURGICAL INC. | COM | 252366109 | 868 | 482,000 | SH | | DFND | 1 | 0 | 482,000 | 0 |
| DURECT CORP | COM | 266605904 | 94 | 770 | SH | Call | DFND | 1 | 0 | 770 | 0 |
| DURECT CORP | COM | 266605104 | 3,099 | 2,540,278 | SH | | DFND | 1 | 0 | 2,540,278 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158201 | 4,236 | 290,505 | SH | | DFND | 1 | 0 | 290,505 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158951 | 8,663 | 5,942 | SH | Put | DFND | 1 | 0 | 5,942 | 0 |
| DYNAVAX TECHNOLOGIES CORP | COM | 268158901 | 15,618 | 10,712 | SH | Call | DFND | 1 | 0 | 10,712 | 0 |
| EDAP TMS S A | ADR | 268311957 | 52 | 157 | SH | Put | DFND | 1 | 0 | 157 | 0 |
| EDAP TMS S A | ADR | 268311107 | 2,804 | 847,225 | SH | | DFND | 1 | 0 | 847,225 | 0 |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 3,473 | 175,249 | SH | | DFND | 1 | 0 | 175,249 | 0 |
| ELI LILLY & CO | COM | 532457958 | 38,517 | 4,891 | SH | Put | DFND | 1 | 0 | 4,891 | 0 |
| ELI LILLY & CO | COM | 532457908 | 237,203 | 30,121 | SH | Call | DFND | 1 | 0 | 30,121 | 0 |
| ENDO INTERNATIONAL PLC | SHS | G30401106 | 936 | 60,061 | SH | | DFND | 1 | 0 | 60,061 | 0 |
| EXELIXIS INC | COM | 30161Q904 | 1,393 | 1,783 | SH | Call | DFND | 1 | 0 | 1,783 | 0 |
| EXPRESS SCRIPTS HOLDING CO. | COM | 30219E103 | 1,242 | 16,386 | SH | | DFND | 1 | 0 | 16,386 | 0 |
| EXPRESS SCRIPTS HOLDING CO. | COM | 30219E953 | 5,041 | 665 | SH | Put | DFND | 1 | 0 | 665 | 0 |
| EYEGATE PHARMACEUTICALS INC | *W | 30233M115 | 2 | 53,893 | SH | | DFND | 1 | 0 | 53,893 | 0 |
| EYEGATE PHARMACEUTICALS INC | COM | 30233M107 | 1,002 | 386,940 | SH | | DFND | 1 | 0 | 386,940 | 0 |
| FIBROGEN INC | COM | 31572Q808 | 1,596 | 97,274 | SH | | DFND | 1 | 0 | 97,274 | 0 |
| FLEXION THERAPEUTICS INC | COM | 33938J106 | 1,508 | 100,800 | SH | | DFND | 1 | 0 | 100,800 | 0 |
| FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 1,611 | 253,706 | SH | | DFND | 1 | 0 | 253,706 | 0 |
| FORWARD PHARMA A/S | ADR | 34986J105 | 1,856 | 102,135 | SH | | DFND | 1 | 0 | 102,135 | 0 |
| GALECTIN THERAPEUTICS INC | COM | 363225202 | 974 | 662,467 | SH | | DFND | 1 | 0 | 662,467 | 0 |
| GALENA BIOPHARMA INC | COM | 363256108 | 53 | 113,530 | SH | | DFND | 1 | 0 | 113,530 | 0 |
| GALENA BIOPHARMA INC | COM | 363256958 | 107 | 2,289 | SH | Put | DFND | 1 | 0 | 2,289 | 0 |
| GENVEC INC | COM | 37246C307 | 931 | 1,625,435 | SH | | DFND | 1 | 0 | 1,625,435 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U908 | 698 | 421 | SH | Call | DFND | 1 | 0 | 421 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U108 | 4,214 | 254,029 | SH | | DFND | 1 | 0 | 254,029 | 0 |
| GW PHARMACEUTICALS PLC | COM | 36197T903 | 1,575 | 172 | SH | Call | DFND | 1 | 0 | 172 | 0 |
| HALOZYME THERAPEUTICS INC | COM | 40637H909 | 1,813 | 2,101 | SH | Call | DFND | 1 | 0 | 2,101 | 0 |
| HCA HOLDINGS INC | COM | 40412C951 | 770 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| HCA HOLDINGS INC | COM | 40412C901 | 71,550 | 9,291 | SH | Call | DFND | 1 | 0 | 9,291 | 0 |
| HEARTWARE INTERNATIONAL INC | COM | 422368950 | 514 | 89 | SH | Put | DFND | 1 | 0 | 89 | 0 |
| HISTOGENICS INC | COM | 43358V109 | 258 | 150,630 | SH | | DFND | 1 | 0 | 150,630 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B955 | 763 | 463 | SH | Put | DFND | 1 | 0 | 463 | 0 |
| HORIZON PHARMA PLC | SHS | G4617B905 | 3,632 | 2,205 | SH | Call | DFND | 1 | 0 | 2,205 | 0 |
| IGNYTA INC | COM | 451731103 | 1,220 | 225,000 | SH | | DFND | 1 | 0 | 225,000 | 0 |
| ILLUMINA INC | COM | 452327109 | 2,808 | 20,000 | SH | | DFND | 1 | 0 | 20,000 | 0 |
| IMMUNOCELLULAR THERAPEUTICS INC | COM | 452536105 | 1,025 | 4,452,128 | SH | | DFND | 1 | 0 | 4,452,128 | 0 |
| IMMUNOMEDICS INC | COM | 452907108 | 986 | 425,000 | SH | | DFND | 1 | 0 | 425,000 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G903 | 22 | 167 | SH | Call | DFND | 1 | 0 | 167 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G953 | 30 | 225 | SH | Put | DFND | 1 | 0 | 225 | 0 |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 30 | 22,500 | SH | | DFND | 1 | 0 | 22,500 | 0 |
| INOTEK PHARMACEUTICALS CORP | COM | 45780V102 | 792 | 106,454 | SH | | DFND | 1 | 0 | 106,454 | 0 |
| INSMED INC | COM | 457669307 | 433 | 43,964 | SH | | DFND | 1 | 0 | 43,964 | 0 |
| INSMED INC | COM | 457669957 | 760 | 771 | SH | Put | DFND | 1 | 0 | 771 | 0 |
| INSMED INC | COM | 457669907 | 1,327 | 1,346 | SH | Call | DFND | 1 | 0 | 1,346 | 0 |
| INTEC PHARMA LTD | SHS | M53644106 | 3,346 | 743,545 | SH | | DFND | 1 | 0 | 743,545 | 0 |
| INTELLIPHARMACEUTICS INTERNATIONAL INC | COM | 458173951 | 19 | 122 | SH | Put | DFND | 1 | 0 | 122 | 0 |
| INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 2,793 | 71,943 | SH | | DFND | 1 | 0 | 71,943 | 0 |
| INTRA CELLULAR THERAPIES INC | COM | 46116X901 | 5,330 | 1,373 | SH | Call | DFND | 1 | 0 | 1,373 | 0 |
| INTRA CELLULAR THERAPIES INC | COM | 46116X951 | 5,695 | 1,467 | SH | Put | DFND | 1 | 0 | 1,467 | 0 |
| INTREXON CORP | COM | 46122T952 | 2,796 | 1,136 | SH | Put | DFND | 1 | 0 | 1,136 | 0 |
| INTREXON CORP | COM | 46122T102 | 2,962 | 120,359 | SH | | DFND | 1 | 0 | 120,359 | 0 |
| INVIVO THERAPEUTICS HOLDINGS CORP | COM | 46186M909 | 58 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| INVIVO THERAPEUTICS HOLDINGS CORP | COM | 46186M209 | 3,354 | 580,343 | SH | | DFND | 1 | 0 | 580,343 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222950 | 2,292 | 984 | SH | Put | DFND | 1 | 0 | 984 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222900 | 8,384 | 3,600 | SH | Call | DFND | 1 | 0 | 3,600 | 0 |
| IPATH S&P 500 MT | ETN | 06740C519 | 5,485 | 3,972 | SH | Call | DFND | 1 | 0 | 3,972 | 0 |
| IPATH S&P 500 VIX | ETN | 06742E901 | 414 | 300 | SH | Call | DFND | 1 | 0 | 300 | 0 |
| ISHARES RUSSELL 2000 ETF | ETF | 464287951 | 156,359 | 13,600 | SH | Put | DFND | 1 | 0 | 13,600 | 0 |
| JOHNSON & JOHNSON | COM | 478160904 | 34,073 | 2,809 | SH | Call | DFND | 1 | 0 | 2,809 | 0 |
| JUNO THERAPEUTICS INC | COM | 48205A909 | 923 | 240 | SH | Call | DFND | 1 | 0 | 240 | 0 |
| KITE PHARMA INC | COM | 49803L909 | 4,255 | 851 | SH | Call | DFND | 1 | 0 | 851 | 0 |
| KITOV PHARMACEUTICALS HOLDINGS | ADR | 49803V107 | 725 | 232,524 | SH | | DFND | 1 | 0 | 232,524 | 0 |
| KITOV PHARMACEUTICALS HOLDINGS | *W | 49803V115 | 944 | 1,210,785 | SH | | DFND | 1 | 0 | 1,210,785 | 0 |
| LA JOLLA PHARMACEUTICAL CO | COM | 503459904 | 2,333 | 1,458 | SH | Call | DFND | 1 | 0 | 1,458 | 0 |
| LA JOLLA PHARMACEUTICAL CO | COM | 503459604 | 3,298 | 206,131 | SH | | DFND | 1 | 0 | 206,131 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872952 | 1,405 | 979 | SH | Put | DFND | 1 | 0 | 979 | 0 |
| LEXICON PHARMACEUTICALS INC | COM | 528872902 | 7,634 | 5,320 | SH | Call | DFND | 1 | 0 | 5,320 | 0 |
| LION BIOTECHNOLOGIES INC | COM | 53619R102 | 2,975 | 367,242 | SH | | DFND | 1 | 0 | 367,242 | 0 |
| LION BIOTECHNOLOGIES INC | COM | 53619R952 | 6,096 | 7,526 | SH | Put | DFND | 1 | 0 | 7,526 | 0 |
| LIPOCINE INC | COM | 53630X104 | 194 | 63,875 | SH | | DFND | 1 | 0 | 63,875 | 0 |
| MANNKIND CORP | COM | 56400P951 | 18,271 | 52,978 | SH | Put | DFND | 1 | 0 | 52,978 | 0 |
| MAST THERAPEUTICS INC | COM | 576314958 | 17 | 369 | SH | Put | DFND | 1 | 0 | 369 | 0 |
| MEDGENICS INC | COM | 58436Q203 | 770 | 138,777 | SH | | DFND | 1 | 0 | 138,777 | 0 |
| MEDICINES CO | COM | 584688105 | 235 | 7,000 | SH | | DFND | 1 | 0 | 7,000 | 0 |
| MEDICINES CO | COM | 584688955 | 336 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| MEDICINES CO | COM | 584688905 | 12,154 | 3,614 | SH | Call | DFND | 1 | 0 | 3,614 | 0 |
| MEDIVATION INC | COM | 58501N951 | 271 | 45 | SH | Put | DFND | 1 | 0 | 45 | 0 |
| MEDIVATION INC | COM | 58501N101 | 271 | 4,500 | SH | | DFND | 1 | 0 | 4,500 | 0 |
| MINERVA NEUROSCIENCES INC | COM | 603380106 | 388 | 38,000 | SH | | DFND | 1 | 0 | 38,000 | 0 |
| MIRATI THERAPEUTICS INC | COM | 60468T955 | 586 | 107,235 | SH | | DFND | 1 | 0 | 107,235 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T950 | 172 | 159 | SH | Put | DFND | 1 | 0 | 159 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 1,572 | 145,600 | SH | | DFND | 1 | 0 | 145,600 | 0 |
| MOMENTA PHARMACEUTICALS INC | COM | 60877T900 | 1,875 | 1,736 | SH | Call | DFND | 1 | 0 | 1,736 | 0 |
| MONSANTO CO | COM | 61166W901 | 55,159 | 5,334 | SH | Call | DFND | 1 | 0 | 5,334 | 0 |
| MYLAN N.V. | SHS | N59465909 | 12,124 | 2,804 | SH | Call | DFND | 1 | 0 | 2,804 | 0 |
| NATERA INC | COM | 632307904 | 174 | 144 | SH | Call | DFND | 1 | 0 | 144 | 0 |
| NEURALSTEM INC | COM | 64127R302 | 1,893 | 6,503,800 | SH | | DFND | 1 | 0 | 6,503,800 | 0 |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C909 | 3,695 | 813 | SH | Call | DFND | 1 | 0 | 813 | 0 |
| NEUROMETRIX INC | COM | 641255500 | 286 | 172,236 | SH | | DFND | 1 | 0 | 172,236 | 0 |
| NEUROMETRIX INC | *W | 641255153 | 612 | 3,060,197 | SH | | DFND | 1 | 0 | 3,060,197 | 0 |
| NEWLINK GENETICS CORP | COM | 651511957 | 97 | 162 | SH | Put | DFND | 1 | 0 | 162 | 0 |
| NEWLINK GENETICS CORP | COM | 651511107 | 318 | 28,261 | SH | | DFND | 1 | 0 | 28,261 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 3,463 | 5,771 | SH | Call | DFND | 1 | 0 | 5,771 | 0 |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 2,951 | 641,492 | SH | | DFND | 1 | 0 | 641,492 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P950 | 47 | 813 | SH | Put | DFND | 1 | 0 | 813 | 0 |
| NORTHWEST BIOTHERAPEUTICS INC | COM | 66737P600 | 512 | 881,585 | SH | | DFND | 1 | 0 | 881,585 | 0 |
| NOVAVAX INC | COM | 670002104 | 1,038 | 142,726 | SH | | DFND | 1 | 0 | 142,726 | 0 |
| NOVAVAX INC | COM | 670002904 | 2,182 | 3,001 | SH | Call | DFND | 1 | 0 | 3,001 | 0 |
| NOVAVAX INC | COM | 670002954 | 7,595 | 10,447 | SH | Put | DFND | 1 | 0 | 10,447 | 0 |
| OCERA THERAPEUTICS INC | COM | 67552A108 | 806 | 424,035 | SH | | DFND | 1 | 0 | 424,035 | 0 |
| ONCOBIOLOGICS INC | *W | 68235M121 | 196 | 436,923 | SH | | DFND | 1 | 0 | 436,923 | 0 |
| ONCOBIOLOGICS INC | *W | 68235M113 | 209 | 426,184 | SH | | DFND | 1 | 0 | 426,184 | 0 |
| ONCOBIOLOGICS INC | COM | 68235M105 | 7,035 | 2,068,968 | SH | | DFND | 1 | 0 | 2,068,968 | 0 |
| ONCOSEC MEDICAL INC | COM | 68234L207 | 997 | 608,052 | SH | | DFND | 1 | 0 | 608,052 | 0 |
| OPGEN INC | COM | 68373L109 | 2,470 | 1,625,000 | SH | | DFND | 1 | 0 | 1,625,000 | 0 |
| OPHTHOTECH CORP | COM | 683745903 | 1,842 | 361 | SH | Call | DFND | 1 | 0 | 361 | 0 |
| OPKO HEALTH INC | COM | 68375N903 | 1,393 | 1,491 | SH | Call | DFND | 1 | 0 | 1,491 | 0 |
| OPKO HEALTH INC | COM | 68375N103 | 1,780 | 190,554 | SH | | DFND | 1 | 0 | 190,554 | 0 |
| OPKO HEALTH INC | COM | 68375N953 | 2,470 | 2,645 | SH | Put | DFND | 1 | 0 | 2,645 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 704 | 135,101 | SH | | DFND | 1 | 0 | 135,101 | 0 |
| PARATEK PHARMACEUTICALS INC | COM | 699374902 | 341 | 245 | SH | Call | DFND | 1 | 0 | 245 | 0 |
| PARATEK PHARMACEUTICALS INC | COM | 699374302 | 4,256 | 305,964 | SH | | DFND | 1 | 0 | 305,964 | 0 |
| PARNELL PHARMACEUTICALS HOLDINGS LTD | SHS | Q73622104 | 635 | 389,400 | SH | | DFND | 1 | 0 | 389,400 | 0 |
| PFIZER INC | COM | 717081903 | 35,210 | 10,000 | SH | Call | DFND | 1 | 0 | 10,000 | 0 |
| PIERIS PHARMACEUTICALS ORD SHS | COM | 720795103 | 2,602 | 1,615,992 | SH | | DFND | 1 | 0 | 1,615,992 | 0 |
| PROGENICS PHARMACEUTICALS INC | COM | 743187956 | 55 | 130 | SH | Put | DFND | 1 | 0 | 130 | 0 |
| PROGENICS PHARMACEUTICALS INC | COM | 743187906 | 152 | 361 | SH | Call | DFND | 1 | 0 | 361 | 0 |
| PROGENICS PHARMACEUTICALS INC | COM | 743187106 | 738 | 174,900 | SH | | DFND | 1 | 0 | 174,900 | 0 |
| PRONAI THERAPEUTICS INC | COM | 74346L101 | 1,174 | 590,011 | SH | | DFND | 1 | 0 | 590,011 | 0 |
| PROQR THERAPEUTICS N.V. | SHS | N71542109 | 532 | 110,000 | SH | | DFND | 1 | 0 | 110,000 | 0 |
| PROVECTUS BIOPHARMACEUTICALS | COM | 74373P108 | 35 | 93,283 | SH | | DFND | 1 | 0 | 93,283 | 0 |
| PSIVIDA CORP | COM | 74440J101 | 730 | 257,800 | SH | | DFND | 1 | 0 | 257,800 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J900 | 1,221 | 1,740 | SH | Call | DFND | 1 | 0 | 1,740 | 0 |
| PUMA BIOTECHNOLOGY INC | COM | 74587V907 | 1,364 | 458 | SH | Call | DFND | 1 | 0 | 458 | 0 |
| QUEST RESOURCE HOLDING CORP | COM | 74836W104 | 382 | 1,315,708 | SH | | DFND | 1 | 0 | 1,315,708 | 0 |
| RADIUS HEALTH INC | COM | 750469957 | 441 | 120 | SH | Put | DFND | 1 | 0 | 120 | 0 |
| RADIUS HEALTH INC | COM | 750469907 | 577 | 157 | SH | Call | DFND | 1 | 0 | 157 | 0 |
| REDHILL BIOPHARMA LTD | COM | 757468103 | 1,611 | 147,500 | SH | | DFND | 1 | 0 | 147,500 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F907 | 1,502 | 43 | SH | Call | DFND | 1 | 0 | 43 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F107 | 24,979 | 71,525 | SH | | DFND | 1 | 0 | 71,525 | 0 |
| REGENERON PHARMACEUTICALS INC | COM | 75886F957 | 40,511 | 1,160 | SH | Put | DFND | 1 | 0 | 1,160 | 0 |
| REGENXBIO INC | COM | 75901B107 | 3,295 | 411,926 | SH | | DFND | 1 | 0 | 411,926 | 0 |
| REGULUS THERAPEUTIC INC | COM | 75915K101 | 142 | 49,231 | SH | | DFND | 1 | 0 | 49,231 | 0 |
| REGULUS THERAPEUTIC INC | COM | 75915K901 | 3,341 | 11,560 | SH | Call | DFND | 1 | 0 | 11,560 | 0 |
| RELYPSA INC | COM | 759531956 | 163 | 88 | SH | Put | DFND | 1 | 0 | 88 | 0 |
| RELYPSA INC | COM | 759531906 | 213 | 115 | SH | Call | DFND | 1 | 0 | 115 | 0 |
| RENNOVA HEALTH INC | *W | 759757115 | 32 | 3,225,806 | SH | | DFND | 1 | 0 | 3,225,806 | 0 |
| RETROPHIN INC | COM | 761299956 | 8,595 | 4,826 | SH | Put | DFND | 1 | 0 | 4,826 | 0 |
| RETROPHIN INC | COM | 761299906 | 16,822 | 9,445 | SH | Call | DFND | 1 | 0 | 9,445 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330909 | 461 | 339 | SH | Call | DFND | 1 | 0 | 339 | 0 |
| REXAHN PHARMACEUTICALS INC | COM | 761640101 | 2,279 | 9,071,168 | SH | | DFND | 1 | 0 | 9,071,168 | 0 |
| RICEBRAN TECHNOLOGIES INC | COM | 762831204 | 1,304 | 785,476 | SH | | DFND | 1 | 0 | 785,476 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559903 | 375 | 1,684 | SH | Call | DFND | 1 | 0 | 1,684 | 0 |
| RIGEL PHARMACEUTICALS INC | COM | 766559603 | 972 | 435,957 | SH | | DFND | 1 | 0 | 435,957 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J108 | 2,077 | 68,950 | SH | | DFND | 1 | 0 | 68,950 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J958 | 10,533 | 3,496 | SH | Put | DFND | 1 | 0 | 3,496 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J908 | 12,079 | 4,009 | SH | Call | DFND | 1 | 0 | 4,009 | 0 |
| SANGAMO BIOSCIENCES INC | COM | 800677906 | 2,548 | 4,400 | SH | Call | DFND | 1 | 0 | 4,400 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607100 | 14,941 | 783,497 | SH | | DFND | 1 | 0 | 783,497 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 29,034 | 15,225 | SH | Call | DFND | 1 | 0 | 15,225 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 55,780 | 29,250 | SH | Put | DFND | 1 | 0 | 29,250 | 0 |
| SCYNEXIS INC | COM | 811292101 | 1,243 | 572,928 | SH | | DFND | 1 | 0 | 572,928 | 0 |
| SERES THERAPEUTICS INC | COM | 81750R902 | 142 | 49 | SH | Call | DFND | 1 | 0 | 49 | 0 |
| SERES THERAPEUTICS INC | COM | 81750R102 | 598 | 20,590 | SH | | DFND | 1 | 0 | 20,590 | 0 |
| SHIRE PLC | COM | 82481R106 | 5,440 | 29,550 | SH | | DFND | 1 | 0 | 29,550 | 0 |
| SHIRE PLC | COM | 82481R906 | 12,849 | 698 | SH | Call | DFND | 1 | 0 | 698 | 0 |
| SHIRE PLC | COM | 82481R956 | 12,849 | 698 | SH | Put | DFND | 1 | 0 | 698 | 0 |
| SKYLINE MEDICAL INC | COM | 83084T309 | 298 | 1,957,037 | SH | | DFND | 1 | 0 | 1,957,037 | 0 |
| SORRENTO THERAPEUTICS INC | COM | 83587F202 | 1,421 | 253,805 | SH | | DFND | 1 | 0 | 253,805 | 0 |
| SPDR GOLD TRUST | SHS | 78463V907 | 12,652 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| SPDR S&P 500 | UNIT | 78462F953 | 176,319 | 8,415 | SH | Put | DFND | 1 | 0 | 8,415 | 0 |
| SPDR S&P 500 BIOTECH | TR | 78464A950 | 10,050 | 1,858 | SH | Put | DFND | 1 | 0 | 1,858 | 0 |
| STAFFING 360 SOLUTIONS INC | COM | 852387208 | 216 | 136,583 | SH | | DFND | 1 | 0 | 136,583 | 0 |
| STRATA SKIN SCIENCES INC | COM | 86272A107 | 623 | 1,020,524 | SH | | DFND | 1 | 0 | 1,020,524 | 0 |
| SUPERCONDUCTOR TECHNOLOGIES INC | COM | 867931404 | 322 | 1,701,245 | SH | | DFND | 1 | 0 | 1,701,245 | 0 |
| TEARLAB CORP. | COM | 878193101 | 1,205 | 1,882,347 | SH | | DFND | 1 | 0 | 1,882,347 | 0 |
| TENAX THERAPEUTICS INC | COM | 88032L100 | 6,671 | 2,606,035 | SH | | DFND | 1 | 0 | 2,606,035 | 0 |
| TENAX THERAPEUTICS INC | COM | 88032L950 | 43 | 169 | SH | Put | DFND | 1 | 0 | 169 | 0 |
| TENAX THERAPEUTICS INC | COM | 88032L900 | 86 | 335 | SH | Call | DFND | 1 | 0 | 335 | 0 |
| TENET HEALTHCARE CORP | COM | 88033G907 | 224 | 81 | SH | Call | DFND | 1 | 0 | 81 | 0 |
| TESARO INC | COM | 881569907 | 18,138 | 2,158 | SH | Call | DFND | 1 | 0 | 2,158 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624959 | 5,023 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| TEVA PHARMACEUTICAL INDUSTRIES LTD | ADR | 881624909 | 18,173 | 3,618 | SH | Call | DFND | 1 | 0 | 3,618 | 0 |
| THERAPEUTICSMD INC | COM | 88338N907 | 980 | 1,153 | SH | Call | DFND | 1 | 0 | 1,153 | 0 |
| TOKAI PHARMACEUTICALS | COM | 88907J107 | 4,128 | 749,205 | SH | | DFND | 1 | 0 | 749,205 | 0 |
| TONIX PHARMACEUTICALS HOLDINGS CORP | COM | 890260201 | 1,166 | 585,914 | SH | | DFND | 1 | 0 | 585,914 | 0 |
| VANDA PHARMACEUTICALS INC | COM | 921659908 | 1,555 | 1,390 | SH | Call | DFND | 1 | 0 | 1,390 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 2,237 | 260 | SH | Put | DFND | 1 | 0 | 260 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 5,239 | 609 | SH | Call | DFND | 1 | 0 | 609 | 0 |
| VIKING THERAPEUTICS INC | *W | 92686J114 | 51 | 176,113 | SH | | DFND | 1 | 0 | 176,113 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 2,431 | 623,317 | SH | | DFND | 1 | 0 | 623,317 | 0 |
| VTV THERAPEUTICS INC | CL A | 918385105 | 811 | 139,747 | SH | | DFND | 1 | 0 | 139,747 | 0 |
| WAFERGEN BIO SYSTEMS INC | COM | 93041P308 | 1,533 | 1,867,250 | SH | | DFND | 1 | 0 | 1,867,250 | 0 |
| WINDTREE THERAPEUTICS INC | COM | 97382D105 | 866 | 448,509 | SH | | DFND | 1 | 0 | 448,509 | 0 |
| XTL BIOPHARMACEUTICALS LTD | ADR | 98386D208 | 1,161 | 1,001,170 | SH | | DFND | 1 | 0 | 1,001,170 | 0 |
| ZAFGEN INC | COM | 98885E903 | 557 | 930 | SH | Call | DFND | 1 | 0 | 930 | 0 |
| ZOGENIX INC | COM | 98978L904 | 2,199 | 12,072 | SH | Call | DFND | 1 | 0 | 12,072 | 0 |
| ZOGENIX INC | COM | 98978L204 | 2,328 | 289,200 | SH | | DFND | 1 | 0 | 289,200 | 0 |
| ZOSANO PHARMA INC | COM | 98979H103 | 170 | 128,600 | SH | | DFND | 1 | 0 | 128,600 | 0 |
