Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBOTT LABORATORIES	COM	002824900	2,347	555	SH	Call	DFND	1	0	555	0
ABBOTT LABORATORIES	COM	002824100	4,774	112,888	SH		DFND	1	0	112,888	0
ABBOTT LABORATORIES	COM	002824950	21,145	5,000	SH	Put	DFND	1	0	5,000	0
ABBVIE INC	COM	00287Y959	7,430	1,178	SH	Put	DFND	1	0	1,178	0
ABBVIE INC	COM	00287Y909	26,086	4,136	SH	Call	DFND	1	0	4,136	0
ACADIA PHARMACEUTICALS INC	COM	00404A959	1,743	548	SH	Put	DFND	1	0	548	0
ACADIA PHARMACEUTICALS INC	COM	00404A909	24,761	7,784	SH	Call	DFND	1	0	7,784	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q951	1,362	1,681	SH	Put	DFND	1	0	1,681	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	7,322	9,039	SH	Call	DFND	1	0	9,039	0
ACORDA THERAPEUTICS INC	COM	00484M906	374	179	SH	Call	DFND	1	0	179	0
ACORDA THERAPEUTICS INC	COM	00484M956	1,176	563	SH	Put	DFND	1	0	563	0
ACORDA THERAPEUTICS INC 15 JUN 21 1.75%	NOTE	00484MAA4	4,160	5,100,000	PRN		DFND	1	0	5,100,000	0
ACTINIUM PHARMACEUTICALS INC	COM	00507W107	1,867	1,382,629	SH		DFND	1	0	1,382,629	0
ACURA PHARMACEUTICALS INC	COM	00509L802	565	352,835	SH		DFND	1	0	352,835	0
ADAMAS PHARMACEUTICALS INC	COM	00548A106	463	28,200	SH		DFND	1	0	28,200	0
ADAMIS PHARMACEUTICALS CORP	COM	00547W958	51	148	SH	Put	DFND	1	0	148	0
ADVERUM BIOTECHNOLOGIES	COM	00773U108	1,655	402,603	SH		DFND	1	0	402,603	0
AERIE PHARMACEUTICALS INC	COM	00771V908	4,453	1,180	SH	Call	DFND	1	0	1,180	0
AETERNA ZENTARIS INC	COM	007975402	230	66,982	SH		DFND	1	0	66,982	0
AETERNA ZENTARIS INC	COM	007975952	254	740	SH	Put	DFND	1	0	740	0
AGENUS INC	COM	00847G955	1,795	2,500	SH	Put	DFND	1	0	2,500	0
AGIOS PHARMACEUTICALS INC	COM	00847X904	21,698	4,108	SH	Call	DFND	1	0	4,108	0
AKARI THERAPEUTICS PLC	ADR	00972G108	148	17,428	SH		DFND	1	0	17,428	0
ALCOBRA LTD	SHS	M2239P109	42	17,058	SH		DFND	1	0	17,058	0
ALCOBRA LTD	SHS	M2239P959	138	559	SH	Put	DFND	1	0	559	0
ALCOBRA LTD	SHS	M2239P909	1,192	4,826	SH	Call	DFND	1	0	4,826	0
ALKERMES PLC	SHS	G01767905	28,201	3,249	SH	Call	DFND	1	0	3,249	0
ALLIQUA BIOMEDICAL INC	COM	019621200	1,031	1,321,726	SH		DFND	1	0	1,321,726	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q957	5,890	869	SH	Put	DFND	1	0	869	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q907	9,815	1,448	SH	Call	DFND	1	0	1,448	0
AMARIN CORPORATION PLC	ADR	023111956	358	1,121	SH	Put	DFND	1	0	1,121	0
AMARIN CORPORATION PLC	ADR	023111906	4,354	13,648	SH	Call	DFND	1	0	13,648	0
AMGEN INC	COM	031162100	22,215	133,176	SH		DFND	1	0	133,176	0
AMGEN INC	COM	031162900	42,853	2,569	SH	Put	DFND	1	0	2,569	0
AMICUS THERAPEUTICS INC	COM	03152W959	1,689	2,282	SH	Put	DFND	1	0	2,282	0
AMICUS THERAPEUTICS INC	COM	03152W909	7,128	9,632	SH	Call	DFND	1	0	9,632	0
AMPLIPHI BIOSCIENCES CORP	COM	03211P202	782	521,378	SH		DFND	1	0	521,378	0
ANAVEX LIFE SCIENCES CORP	COM	032797950	311	858	SH	Put	DFND	1	0	858	0
ANTHERA PHARMACEUTICALS INC	COM	03674U201	297	94,201	SH		DFND	1	0	94,201	0
ANTHERA PHARMACEUTICALS INC	COM	03674U901	668	2,121	SH	Call	DFND	1	0	2,121	0
ARBUTUS BIOPHARMA CORP	COM	03879J900	670	1,949	SH	Call	DFND	1	0	1,949	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	3,022	878,531	SH		DFND	1	0	878,531	0
ASSEMBLY BIOSCIENCES INC	COM	045396108	542	75,200	SH		DFND	1	0	75,200	0
ASTERIAS BIOTHERAPEUTICS INC	COM	04624N907	85	200	SH	Call	DFND	1	0	200	0
ASTRAZENECA PLC	COM	046353908	11,567	3,520	SH	Call	DFND	1	0	3,520	0
ATHERSYS INC	COM	04744L106	190	89,139	SH		DFND	1	0	89,139	0
ATHERSYS INC	COM	04744L956	101	476	SH	Put	DFND	1	0	476	0
AVEXIS ORD SHS	COM	05366U100	412	10,000	SH		DFND	1	0	10,000	0
AXOVANT SCIENCES LTD	COM	G0750W104	1,304	93,109	SH		DFND	1	0	93,109	0
AXOVANT SCIENCES LTD	COM	G0750W904	6,552	4,680	SH	Call	DFND	1	0	4,680	0
BARCLAYS BANK PLC	IPATH	06740Q260	2,215	65,000	SH		DFND	1	0	65,000	0
BENITEC BIOPHARMA LTD	ADR	82053307	385	274,573	SH		DFND	1	0	274,573	0
BENITEC BIOPHARMA LTD	*W	082053117	17	98,146	SH		DFND	1	0	98,146	0
BIO PATH HOLDINGS INC	COM	09057N102	1,841	1,314,692	SH		DFND	1	0	1,314,692	0
BIOBLAST PHARMA LTD	SHS	M20156101	1,356	784,057	SH		DFND	1	0	784,057	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V903	1,140	2,584	SH	Call	DFND	1	0	2,584	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J906	478	1,770	SH	Call	DFND	1	0	1,770	0
BIODELIVERY SCIENCES INTERNATIONAL INC	COM	09060J106	1,863	689,900	SH		DFND	1	0	689,900	0
BIOGEN INC	COM	09062X953	3,130	100	SH	Put	DFND	1	0	100	0
BIOGEN INC	COM	09062X903	20,879	667	SH	Call	DFND	1	0	667	0
BIOPHARMX CORP	COM	09072X101	363	654,462	SH		DFND	1	0	654,462	0
BLUEBIRD BIO INC	COM	09609G900	9,354	1,380	SH	Call	DFND	1	0	1,380	0
BLUEPRINT MEDICINES CORP	COM	09627Y959	564	190	SH	Put	DFND	1	0	190	0
BRAINSTORM CELL THERAPEUTICS	COM	10501E201	1,062	444,500	SH		DFND	1	0	444,500	0
BRISTOL MYERS SQUIBB CO.	COM	110122108	8,459	156,887	SH		DFND	1	0	156,887	0
BRISTOL MYERS SQUIBB CO.	COM	110122958	18,705	3,469	SH	Put	DFND	1	0	3,469	0
BRISTOL MYERS SQUIBB CO.	COM	110122908	29,165	5,409	SH	Call	DFND	1	0	5,409	0
CALITHERA BIOSCIENCES INC.	COM	13089P101	1,055	324,500	SH		DFND	1	0	324,500	0
CANCER GENETICS INC	COM	13739U104	191	109,048	SH		DFND	1	0	109,048	0
CAPNIA INC.	COM	14066L105	236	245,737	SH		DFND	1	0	245,737	0
CAPRICOR THERAPEUTICS INC.	COM	14070B101	1,183	357,436	SH		DFND	1	0	357,436	0
CARDIOME PHARMA CORP	COM	14159U301	1,521	484,505	SH		DFND	1	0	484,505	0
CASCADIAN THERAPEUTICS INC.	COM	14740B101	392	238,899	SH		DFND	1	0	238,899	0
CEL SCI CORP	COM	150837508	1,029	3,372,642	SH		DFND	1	0	3,372,642	0
CELGENE CORP	COM	151020104	3,944	37,728	SH		DFND	1	0	37,728	0
CELGENE CORP	COM	151020954	25,244	2,415	SH	Put	DFND	1	0	2,415	0
CELGENE CORP	COM	151020904	36,073	3,451	SH	Call	DFND	1	0	3,451	0
CELLECT BIOTECHNOLOGY LTD	ADS	15116C102	264	57,348	SH		DFND	1	0	57,348	0
CELLECTAR BIOSCIENCES INC	*W	15117F120	188	228,788	SH		DFND	1	0	228,788	0
CELSION CORP.	COM	15117N404	1,091	894,406	SH		DFND	1	0	894,406	0
CEMPRA INC	COM	15130J909	7,306	3,019	SH	Call	DFND	1	0	3,019	0
CEMPRA INC	COM	15130J959	15,302	6,323	SH	Put	DFND	1	0	6,323	0
CHAMPIONS ONCOLOGY INC	COM	15870P307	905	538,593	SH		DFND	1	0	538,593	0
CHECK CAP LTD	SHS	M2361E112	1,159	585,569	SH		DFND	1	0	585,569	0
CHIMERIX INC.	COM	16934W106	443	79,900	SH		DFND	1	0	79,900	0
CIDARA THERAPEUTICS INC.	COM	171757107	2,180	190,358	SH		DFND	1	0	190,358	0
CLOVIS ONCOLOGY INC	COM	189464950	7,538	2,091	SH	Put	DFND	1	0	2,091	0
CLOVIS ONCOLOGY INC	COM	189464900	21,089	5,850	SH	Call	DFND	1	0	5,850	0
COMBIMATRIX CORP.	*W	20009T147	429	857,746	SH		DFND	1	0	857,746	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668108	359	31,122	SH		DFND	1	0	31,122	0
COMMUNITY HEALTH SYSTEMS INC	COM	203668958	477	413	SH	Put	DFND	1	0	413	0
CYTORI THERAPEUTICS INC.	*W	23283K121	1,547	895,017	SH		DFND	1	0	895,017	0
CYTORI THERAPEUTICS INC.	COM	23283K204	3,579	1,762,846	SH		DFND	1	0	1,762,846	0
CYTRX CORP.	COM	232828509	4,368	7,424,786	SH		DFND	1	0	7,424,786	0
DEPOMED INC	COM	249908904	10,798	4,321	SH	Call	DFND	1	0	4,321	0
DERMIRA INC	COM	24983L954	2,293	678	SH	Put	DFND	1	0	678	0
DERMIRA INC	COM	24983L904	2,442	722	SH	Call	DFND	1	0	722	0
DEXCOM INC	COM	252131907	7,065	806	SH	Call	DFND	1	0	806	0
DEXTERA SURGICAL INC	COM	252366109	851	450,507	SH		DFND	1	0	450,507	0
DICERNA PHARMACEUTICALS INC	COM	253031108	294	50,000	SH		DFND	1	0	50,000	0
DRAGONWAVE INC.	COM	26144M400	1,018	378,338	SH		DFND	1	0	378,338	0
DURECT CORP	COM	266605904	245	1,759	SH	Call	DFND	1	0	1,759	0
DURECT CORP	COM	266605104	2,502	1,800,000	SH		DFND	1	0	1,800,000	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	5,474	521,875	SH		DFND	1	0	521,875	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	8,002	7,628	SH	Put	DFND	1	0	7,628	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	10,473	9,984	SH	Call	DFND	1	0	9,984	0
EDAP TMS S A	ADR	268311957	53	182	SH	Put	DFND	1	0	182	0
EDAP TMS S A	ADR	268311107	1,583	545,918	SH		DFND	1	0	545,918	0
EDITAS MEDICINE INC.	COM	28106W103	1,820	135,000	SH		DFND	1	0	135,000	0
EIGER BIOPHARMACEUTICALS INC.	COM	28249U105	3,090	230,803	SH		DFND	1	0	230,803	0
ELI LILLY & CO	COM	532457958	39,311	4,898	SH	Put	DFND	1	0	4,898	0
ELI LILLY & CO	COM	532457908	235,539	29,347	SH	Call	DFND	1	0	29,347	0
ENDO INTERNATIONAL PLC	SHS	G30401106	1,194	59,237	SH		DFND	1	0	59,237	0
ENDO INTERNATIONAL PLC	SHS	G30401956	2,208	1,096	SH	Put	DFND	1	0	1,096	0
EVOKE PHARMA INC.	COM	30049G104	144	63,768	SH		DFND	1	0	63,768	0
EXACT SCIENCES CORP	COM	30063P955	2,137	1,153	SH	Put	DFND	1	0	1,153	0
EXELIXIS INC	COM	30161Q904	2,468	1,930	SH	Call	DFND	1	0	1,930	0
EXELIXIS INC	COM	30161Q954	6,896	5,392	SH	Put	DFND	1	0	5,392	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G958	11,927	1,691	SH	Put	DFND	1	0	1,691	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G908	20,433	2,897	SH	Call	DFND	1	0	2,897	0
EYEGATE PHARMACEUTICALS INC	*W	30233M115	16	46,968	SH		DFND	1	0	46,968	0
EYEGATE PHARMACEUTICALS INC	COM	30233M107	834	508,598	SH		DFND	1	0	508,598	0
FIBROGEN INC	COM	31572Q908	339	164	SH	Call	DFND	1	0	164	0
FIBROGEN INC	COM	31572Q808	1,504	72,669	SH		DFND	1	0	72,669	0
FLEXION THERAPEUTICS INC	COM	33938J106	238	12,176	SH		DFND	1	0	12,176	0
FLEXION THERAPEUTICS INC	COM	33938J956	395	202	SH	Put	DFND	1	0	202	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135905	670	724	SH	Call	DFND	1	0	724	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	1,866	201,564	SH		DFND	1	0	201,564	0
FORWARD PHARMA A/S	ADR	34986J105	2,080	99,053	SH		DFND	1	0	99,053	0
GALECTIN THERAPEUTICS INC	COM	363225952	93	825	SH	Put	DFND	1	0	825	0
GALECTIN THERAPEUTICS INC	COM	363225202	99	87,999	SH		DFND	1	0	87,999	0
GALENA BIOPHARMA INC	COM	363256108	49	141,000	SH		DFND	1	0	141,000	0
GALENA BIOPHARMA INC	COM	363256958	57	1,624	SH	Put	DFND	1	0	1,624	0
GENVEC INC	COM	37246C307	696	1,510,377	SH		DFND	1	0	1,510,377	0
GILEAD SCIENCES INC	COM	375558953	6,100	771	SH	Put	DFND	1	0	771	0
GILEAD SCIENCES INC	COM	375558903	92,499	11,691	SH	Call	DFND	1	0	11,691	0
GLOBAL BLOOD THERAPEUTICS INC	COM	37890U908	1,662	721	SH	Call	DFND	1	0	721	0
GREAT PANTHER SILVER LTD	COM	39115V101	55	40,450	SH		DFND	1	0	40,450	0
GW PHARMACEUTICALS PLC	ADS	36197T953	2,548	192	SH	Put	DFND	1	0	192	0
GW PHARMACEUTICALS PLC	ADS	36197T903	3,624	273	SH	Call	DFND	1	0	273	0
HALOZYME THERAPEUTICS INC	COM	40637H909	5,920	4,901	SH	Call	DFND	1	0	4,901	0
HCA HOLDINGS INC	COM	40412C951	2,390	316	SH	Put	DFND	1	0	316	0
HCA HOLDINGS INC	COM	40412C901	58,084	7,680	SH	Call	DFND	1	0	7,680	0
HEMISPHERX BIOPHARMA INC.	COM	42366C301	1,690	1,351,850	SH		DFND	1	0	1,351,850	0
HESS CORP	COM	42809H907	11,040	2,059	SH	Call	DFND	1	0	2,059	0
HISTOGENICS CORP.	COM	43358V109	151	47,823	SH		DFND	1	0	47,823	0
HORIZON PHARMA PLC	COM	G4617B955	839	463	SH	Put	DFND	1	0	463	0
HORIZON PHARMA PLC	COM	G4617B905	7,412	4,088	SH	Call	DFND	1	0	4,088	0
HUMANA INC	COM	444859902	4,918	278	SH	Call	DFND	1	0	278	0
HUMANA INC	COM	444859952	12,382	700	SH	Put	DFND	1	0	700	0
IGNYTA INC	COM	451731103	1,421	225,900	SH		DFND	1	0	225,900	0
IMMUNOCELLULAR THERAPEUTICS	COM	452536105	756	6,405,230	SH		DFND	1	0	6,405,230	0
IMMUNOCELLULAR THERAPEUTICS	*W	452536113	1,077	15,161,641	SH		DFND	1	0	15,161,641	0
IMMUNOMEDICS INC.	COM	452907108	966	297,310	SH		DFND	1	0	297,310	0
INCYTE CORP	COM	45337C902	339	36	SH	Call	DFND	1	0	36	0
INFINITY PHARMACEUTICALS INC	COM	45665G903	26	167	SH	Call	DFND	1	0	167	0
INOTEK PHARMACEUTICALS CORP	COM	45780V902	100	106	SH	Call	DFND	1	0	106	0
INOTEK PHARMACEUTICALS CORP	COM	45780V952	474	500	SH	Put	DFND	1	0	500	0
INOTEK PHARMACEUTICALS CORP	COM	45780V102	1,365	144,002	SH		DFND	1	0	144,002	0
INSMED INC	COM	457669957	1,811	1,247	SH	Put	DFND	1	0	1,247	0
INSMED INC	COM	457669907	2,118	1,459	SH	Call	DFND	1	0	1,459	0
INSPIREMD INC	COM	45779A507	54	679,224	SH		DFND	1	0	679,224	0
INSPIREMD INC	*W	45779A119	888	29,594,500	SH		DFND	1	0	29,594,500	0
INTEC PHARMA LTD.	COM	M53644106	2,898	498,006	SH		DFND	1	0	498,006	0
INTELLIA THERAPEUTICS INC	COM	45826J105	1,784	104,841	SH		DFND	1	0	104,841	0
INTRA CELLULAR THERAPIES INC	COM	46116X951	226	148	SH	Put	DFND	1	0	148	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	226	14,800	SH		DFND	1	0	14,800	0
INTRA CELLULAR THERAPIES INC	COM	46116X901	812	533	SH	Call	DFND	1	0	533	0
INVIVO THERAPEUTICS HOLDINGS CORP	COM	46186M909	135	199	SH	Call	DFND	1	0	199	0
IONIS PHARMACEUTICALS INC	COM	462222950	2,700	737	SH	Put	DFND	1	0	737	0
IONIS PHARMACEUTICALS INC	COM	462222900	7,955	2,171	SH	Call	DFND	1	0	2,171	0
ISHARES RUSSELL 2000	ETF	464287905	67,583	5,441	SH	Call	DFND	1	0	5,441	0
ISHARES RUSSELL 2000	ETF	464287955	184,973	14,892	SH	Put	DFND	1	0	14,892	0
JUNO THERAPEUTICS INC	COM	48205A909	309	103	SH	Call	DFND	1	0	103	0
KITE PHARMA INC	COM	49803L909	6,044	1,082	SH	Call	DFND	1	0	1,082	0
KITE PHARMA INC	COM	49803L959	6,575	1,177	SH	Put	DFND	1	0	1,177	0
LA JOLLA PHARMACEUTICAL CO	COM	503459604	2,878	120,964	SH		DFND	1	0	120,964	0
LA JOLLA PHARMACEUTICAL CO	COM	503459904	4,910	2,064	SH	Call	DFND	1	0	2,064	0
LEXICON PHARMACEUTICALS INC	COM	528872952	1,084	600	SH	Put	DFND	1	0	600	0
LEXICON PHARMACEUTICALS INC	COM	528872902	11,317	6,263	SH	Call	DFND	1	0	6,263	0
LION BIOTECHNOLOGIES INC	COM	53619R902	408	496	SH	Call	DFND	1	0	496	0
LION BIOTECHNOLOGIES INC	COM	53619R102	2,027	246,342	SH		DFND	1	0	246,342	0
LION BIOTECHNOLOGIES INC	COM	53619R952	6,503	7,901	SH	Put	DFND	1	0	7,901	0
MANNKIND CORP	COM	56400P201	1,107	1,785,368	SH		DFND	1	0	1,785,368	0
MANNKIND CORP	COM	56400P951	3,863	62,303	SH	Put	DFND	1	0	62,303	0
MEDGENICS INC	COM	58436Q903	297	533	SH	Call	DFND	1	0	533	0
MEDGENICS INC	COM	58436Q203	791	141,977	SH		DFND	1	0	141,977	0
MEDICINES CO	COM	584688955	377	100	SH	Put	DFND	1	0	100	0
MEDICINES CO	COM	584688105	510	13,508	SH		DFND	1	0	13,508	0
MEDICINES CO	COM	584688905	4,340	1,150	SH	Call	DFND	1	0	1,150	0
MEDIGUS LTD	COM	58471G102	1,373	1,042,813	SH		DFND	1	0	1,042,813	0
MERCK & CO INC	COM	58933Y905	28,003	4,487	SH	Call	DFND	1	0	4,487	0
MIRATI THERAPEUTICS INC.	COM	60468T105	659	99,735	SH		DFND	1	0	99,735	0
MOMENTA PHARMACEUTICALS INC	COM	60877T900	321	275	SH	Call	DFND	1	0	275	0
MONSANTO CO	COM	61166W901	57,304	5,607	SH	Call	DFND	1	0	5,607	0
MYLAN N.V.	SHS	N59465909	10,689	2,804	SH	Call	DFND	1	0	2,804	0
NATERA INC	COM	632307904	161	145	SH	Call	DFND	1	0	145	0
NEURALSTEM INC.	COM	64127R302	892	2,787,745	SH		DFND	1	0	2,787,745	0
NEUROCRINE BIOSCIENCES INC	COM	64125C909	6,148	1,214	SH	Call	DFND	1	0	1,214	0
NEUROMETRIX INC	COM	641255500	338	219,336	SH		DFND	1	0	219,336	0
NEUROMETRIX INC	*W	641255153	400	3,060,947	SH		DFND	1	0	3,060,947	0
NEVRO CORP	COM	64157F903	1,681	161	SH	Call	DFND	1	0	161	0
NEWLINK GENETICS CORP	COM	651511957	150	100	SH	Put	DFND	1	0	100	0
NEWLINK GENETICS CORP	COM	651511107	519	34,561	SH		DFND	1	0	34,561	0
NEWLINK GENETICS CORP	COM	651511907	4,336	2,887	SH	Call	DFND	1	0	2,887	0
NIVALIS THERAPEUTICS INC	COM	65481J109	2,176	267,650	SH		DFND	1	0	267,650	0
NOVAVAX INC	COM	670002954	176	844	SH	Put	DFND	1	0	844	0
NOVAVAX INC	COM	670002904	457	2,195	SH	Call	DFND	1	0	2,195	0
NOVO NORDISK A/S	ADR	670100955	3,573	859	SH	Put	DFND	1	0	859	0
OCERA THERAPEUTICS INC	COM	67552A108	1,060	400,035	SH		DFND	1	0	400,035	0
OCULAR THERAPEUTIX INC	COM	67576A100	262	38,100	SH		DFND	1	0	38,100	0
ONCOBIOLOGICS INC	*W	68235M113	905	902,050	SH		DFND	1	0	902,050	0
ONCOBIOLOGICS INC	*W	68235M121	1,332	926,651	SH		DFND	1	0	926,651	0
ONCOBIOLOGICS INC	COM	68235M105	9,643	2,268,585	SH		DFND	1	0	2,268,858	0
ONCONOVA THERAPEUTICS INC	COM	68232V306	1,039	392,023	SH		DFND	1	0	392,023	0
ONCONOVA THERAPEUTICS INC	*W	68232V116	1,124	725,434	SH		DFND	1	0	725,434	0
ONCOSEC MEDICAL INC	COM	68234L207	1,426	834,004	SH		DFND	1	0	834,004	0
OPGEN INC.	COM	68373L109	3,545	2,161,467	SH		DFND	1	0	2,161,467	0
OPHTHOTECH CORP	COM	683745903	6,998	1,517	SH	Call	DFND	1	0	1,517	0
OPKO HEALTH INC	COM	68375N953	2,147	2,027	SH	Put	DFND	1	0	2,027	0
OPKO HEALTH INC	COM	68375N903	2,638	2,491	SH	Call	DFND	1	0	2,491	0
OVASCIENCE INC	COM	69014Q101	358	50,000	SH		DFND	1	0	50,000	0
PACIRA PHARMACEUTICALS INC	COM	695127950	544	159	SH	Put	DFND	1	0	159	0
PACIRA PHARMACEUTICALS INC	COM	695127900	1,057	309	SH	Call	DFND	1	0	309	0
PARATEK PHARMACEUTICALS INC	COM	699374302	2,277	175,000	SH		DFND	1	0	175,000	0
PARNELL PHARMACEUTICALS HOLDINGS LTD	SHS	Q73622104	532	369,700	SH		DFND	1	0	369,700	0
PIERIS PHARMACEUTICALS INC	COM	720795103	2,824	1,543,307	SH		DFND	1	0	1,543,307	0
PORTOLA PHARMACEUTICALS INC	COM	737010908	681	300	SH	Call	DFND	1	0	300	0
PRONAI THERAPEUTICS INC.	COM	74346L101	1,252	687,734	SH		DFND	1	0	687,734	0
PROQR THERAPEUTICS N V	COM	N71542109	393	58,910	SH		DFND	1	0	58,910	0
PROTHENA CORPORATION PLC	SHS	G72800990	1,949	325	SH	Call	DFND	1	0	325	0
PROVECTUS BIOPHARMACEUTICALS INC	COM	74373P108	107	1,077,555	SH		DFND	1	0	1,077,555	0
PSIVIDA CORP	COM	74440J101	587	195,100	SH		DFND	1	0	195,100	0
PTC THERAPEUTICS INC	COM	69366J900	5,589	3,989	SH	Call	DFND	1	0	3,989	0
PUMA BIOTECHNOLOGY INC	COM	74587V957	4,311	643	SH	Put	DFND	1	0	643	0
PUMA BIOTECHNOLOGY INC	COM	74587V907	13,551	2,021	SH	Call	DFND	1	0	2,021	0
QUEST RESOURCE HOLDING CORP	COM	74836W203	281	138,980	SH		DFND	1	0	138,980	0
RADIUS HEALTH INC	COM	750469957	763	141	SH	Put	DFND	1	0	141	0
RADIUS HEALTH INC	COM	750469907	1,055	195	SH	Call	DFND	1	0	195	0
REDHILL BIOPHARMA LTD	ADS	757468103	888	63,800	SH		DFND	1	0	63,800	0
REGENERON PHARMACEUTICALS INC	COM	75886F907	2,533	63	SH	Call	DFND	1	0	63	0
REGENERON PHARMACEUTICALS INC	COM	75886F107	30,521	75,919	SH		DFND	1	0	75,919	0
REGENERON PHARMACEUTICALS INC	COM	75886F957	72,042	1,792	SH	Put	DFND	1	0	1,792	0
REGENXBIO ORD SHS	COM	75901B107	3,687	263,177	SH		DFND	1	0	263,177	0
REGULUS THERAPEUTIC INC	COM	75915K901	3,630	11,000	SH	Call	DFND	1	0	11,000	0
RENNOVA HEALTH INC	*W	759757123	258	3,682,014	SH		DFND	1	0	3,682,014	0
RENNOVA HEALTH INC	COM	759757107	516	2,724,721	SH		DFND	1	0	2,724,721	0
RETROPHIN INC	COM	761299956	897	401	SH	Put	DFND	1	0	401	0
RETROPHIN INC	COM	761299906	14,084	6,293	SH	Call	DFND	1	0	6,293	0
REXAHN PHARMACEUTICALS INC	COM	761640101	1,988	9,464,849	SH		DFND	1	0	9,464,849	0
RICEBRAN TECHNOLOGIES	COM	762831204	1,073	794,436	SH		DFND	1	0	794,436	0
RIGEL PHARMACEUTICALS INC	COM	766559903	116	316	SH	Call	DFND	1	0	316	0
RIGEL PHARMACEUTICALS INC	COM	766559603	319	86,900	SH		DFND	1	0	86,900	0
SAGE THERAPEUTICS INC	COM	78667J958	1,220	265	SH	Put	DFND	1	0	265	0
SAGE THERAPEUTICS INC	COM	78667J908	5,365	1,165	SH	Call	DFND	1	0	1,165	0
SANGAMO BIOSCIENCES INC	COM	800677106	152	32,804	SH		DFND	1	0	32,804	0
SANGAMO BIOSCIENCES INC	COM	800677906	2,598	5,611	SH	Call	DFND	1	0	5,611	0
SAREPTA THERAPEUTICS INC	COM	803607900	21,653	3,526	SH	Call	DFND	1	0	3,526	0
SAREPTA THERAPEUTICS INC	COM	803607100	32,933	536,282	SH		DFND	1	0	536,282	0
SAREPTA THERAPEUTICS INC	COM	803607950	164,259	26,748	SH	Put	DFND	1	0	26,748	0
SHIRE PLC	COM	82481R106	6,043	31,172	SH		DFND	1	0	31,172	0
SHIRE PLC	COM	82481R906	13,531	698	SH	Call	DFND	1	0	698	0
SHIRE PLC	COM	82481R956	13,531	698	SH	Put	DFND	1	0	698	0
SOPHIRIS BIO INC.	COM	83578Q209	2,354	757,033	SH		DFND	1	0	757,033	0
SORRENTO THERAPEUTICS INC	COM	83587F902	127	164	SH	Call	DFND	1	0	164	0
SORRENTO THERAPEUTICS INC	COM	83587F202	162	20,986	SH		DFND	1	0	20,986	0
SPDR S&P 500 ETF TRUST	UNIT	78462F903	216,300	10,000	SH	Call	DFND	1	0	10,000	0
SPDR S&P 500 ETF TRUST	UNIT	78462F953	302,820	14,000	SH	Put	DFND	1	0	14,000	0
SPDR SERIES TRUST	UNIT	78464A950	12,980	1,958	SH	Put	DFND	1	0	1,958	0
STEMLINE THERAPEUTICS INC	COM	85858C907	240	222	SH	Call	DFND	1	0	222	0
STEMLINE THERAPEUTICS INC	COM	85858C107	1,062	98,050	SH		DFND	1	0	98,050	0
STRATA SKIN SCIENCES INC	COM	86272A107	510	1,000,790	SH		DFND	1	0	1,000,790	0
SUNSHINE HEART INC.	COM	86782U106	518	908,021	SH		DFND	1	0	908,021	0
SUPERCONDUCTOR TECHNOLOGIES INC.	COM	867931503	669	250,474	SH		DFND	1	0	250,474	0
SYNERGY PHARMACEUTICALS INC.	*W	871639118	268	348,743	SH		DFND	1	0	348,743	0
SYNERGY PHARMACEUTICALS INC.	COM	871639958	2,117	3,842	SH	Put	DFND	1	0	3,842	0
SYNERGY PHARMACEUTICALS INC.	COM	871639908	4,360	7,912	SH	Call	DFND	1	0	7,912	0
TENAX THERAPEUTICS INC	COM	88032L950	39	169	SH	Put	DFND	1	0	169	0
TENAX THERAPEUTICS INC	COM	88032L900	583	2,534	SH	Call	DFND	1	0	2,534	0
TENAX THERAPEUTICS INC	COM	88032L100	5,550	2,412,857	SH		DFND	1	0	2,412,857	0
TENET HEALTHCARE CORP	COM	88033G407	2,557	112,831	SH		DFND	1	0	112,831	0
TENET HEALTHCARE CORP	COM	88033G957	3,952	1,744	SH	Put	DFND	1	0	1,744	0
TENET HEALTHCARE CORP	COM	88033G907	7,204	3,179	SH	Call	DFND	1	0	3,179	0
TESARO INC	COM	881569957	501	50	SH	Put	DFND	1	0	50	0
TESARO INC	COM	881569107	2,757	27,500	SH		DFND	1	0	27,500	0
TESARO INC	COM	881569907	3,338	333	SH	Call	DFND	1	0	333	0
THERAPEUTICSMD INC	COM	88338N107	232	34,030	SH		DFND	1	0	34,030	0
THERAPEUTICSMD INC	COM	88338N957	399	586	SH	Put	DFND	1	0	586	0
THERAPEUTICSMD INC	COM	88338N907	1,301	1,910	SH	Call	DFND	1	0	1,910	0
TOKAI PHARMACEUTICALS INC.	COM	88907J107	492	321,600	SH		DFND	1	0	321,600	0
TONIX PHARMACEUTICALS HOLDING CORP.	COM	890260201	142	203,097	SH		DFND	1	0	203,097	0
UNITED THERAPEUTICS CORP	COM	91307C102	3,319	28,112	SH		DFND	1	0	28,112	0
UNITED THERAPEUTICS CORP	COM	91307C952	12,965	1,098	SH	Put	DFND	1	0	1,098	0
VANDA PHARMACEUTICALS INC	COM	921659908	2,075	1,247	SH	Call	DFND	1	0	1,247	0
VERSARTIS INC.	COM	92529L102	2,143	174,968	SH		DFND	1	0	174,968	0
VERTEX PHARMACEUTICALS INC	COM	92532F950	2,267	260	SH	Put	DFND	1	0	260	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	17,050	1,955	SH	Call	DFND	1	0	1,955	0
VIKING THERAPEUTICS INC	*W	92686J114	53	117,008	SH		DFND	1	0	117,008	0
VISTAGEN THERAPEUTICS INC	COM	92840H202	1,452	349,096	SH		DFND	1	0	349,096	0
VTV THERAPEUTICS INC	CL A	918385105	969	134,747	SH		DFND	1	0	134,747	0
WAFERGEN BIO SYSTEMS INC.	COM	93041P308	1,520	1,578,616	SH		DFND	1	0	1,578,616	0
WINDTREE THERAPEUTICS INC.	COM	97382D105	797	310,000	SH		DFND	1	0	310,000	0
XTL BIOPHARMACEUTICALS LTD	ADR	98386D208	714	751,289	SH		DFND	1	0	751,289	0
ZAFGEN INC	COM	98885E903	15	2,149	SH	Call	DFND	1	0	2,149	0
ZOGENIX INC	COM	98978L204	1,715	150,000	SH		DFND	1	0	150,000	0
ZOGENIX INC	COM	98978L904	3,265	1,228	SH	Call	DFND	1	0	1,228	0
ZOSANO PHARMA CORP.	COM	98979H103	82	103,600	SH		DFND	1	0	103,600	0