Sabby Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBVIE INC	COM	00287Y909	13,801	2,204	SH	Call	DFND	1	0	2,204	0
ABBVIE INC	COM	00287Y959	7,377	1,178	SH	Put	DFND	1	0	1,178	0
ACADIA PHARMACEUTICALS INC	COM	004225908	18,659	6,470	SH	Call	DFND	1	0	6,470	0
ACADIA PHARMACEUTICALS INC	COM	004225958	1,580	548	SH	Put	DFND	1	0	548	0
ACHILLION PHARMACEUTICALS INC	COM	00448Q901	4,166	10,087	SH	Call	DFND	1	0	10,087	0
ACORDA THERAPEUTICS INC	COM	00484M106	4,962	263,947	SH		DFND	1	0	263,947	0
ACORDA THERAPEUTICS INC	COM	00484M906	748	398	SH	Call	DFND	1	0	398	0
ACORDA THERAPEUTICS INC	COM	00484M956	11,553	6,145	SH	Put	DFND	1	0	6,145	0
ACTINIUM PHARMACEUTICALS INC	COM	00507W107	760	868,608	SH		DFND	1	0	868,608	0
ACURA PHARMACEUTICALS INC.	COM	00509L802	79	103,444	SH		DFND	1	0	103,444	0
ADAMIS PHARMACEUTICALS CORP	COM	00547W958	42	134	SH	Put	DFND	1	0	134	0
ADVAXIS INC	COM	007624208	75	10,443	SH		DFND	1	0	10,443	0
ADVAXIS INC	COM	007624908	193	270	SH	Call	DFND	1	0	270	0
ADVAXIS INC	COM	007624958	296	414	SH	Put	DFND	1	0	414	0
ADVERUM BIOTECHNOLOGIES INC.	COM	00773U108	822	283,306	SH		DFND	1	0	283,306	0
AETERNA ZENTARIS INC	COM	007975402	1,442	400,560	SH		DFND	1	0	400,560	0
AETERNA ZENTARIS INC	COM	007975952	221	614	SH	Put	DFND	1	0	614	0
AEVI GENOMIC MEDICINE INC.	COM	00835P105	716	138,195	SH		DFND	1	0	138,195	0
AGENUS INC	COM	00847G955	1,031	2,503	SH	Put	DFND	1	0	2,503	0
AGIOS PHARMACEUTICALS INC	COM	00847X904	2,274	545	SH	Call	DFND	1	0	545	0
AKARI THERAPEUTICS PLC	ADR	00972G108	120	17,428	SH		DFND	1	0	17,428	0
ALCOBRA LTD	SHS	M2239P109	193	91,858	SH		DFND	1	0	91,858	0
ALCOBRA LTD	SHS	M2239P909	651	3,102	SH	Call	DFND	1	0	3,102	0
ALCOBRA LTD	SHS	M2239P959	117	559	SH	Put	DFND	1	0	559	0
ALEXION PHARMACEUTICALS INC	COM	015351909	19,405	1,586	SH	Call	DFND	1	0	1,586	0
ALKERMES PLC	SHS	G01767905	9,110	1,639	SH	Call	DFND	1	0	1,639	0
ALLIQUA BIOMEDICAL INC	COM	019621200	649	1,100,398	SH		DFND	1	0	1,100,398	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	518	13,823	SH		DFND	1	0	13,823	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q907	4,643	1,240	SH	Call	DFND	1	0	1,240	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q957	7,698	2,056	SH	Put	DFND	1	0	2,056	0
AMARIN CORPORATION PLC	ADR	023111906	3,803	12,346	SH	Call	DFND	1	0	12,346	0
AMARIN CORPORATION PLC	ADR	023111956	344	1,118	SH	Put	DFND	1	0	1,118	0
AMGEN INC	COM	031162100	36,961	252,795	SH		DFND	1	0	252,795	0
AMGEN INC	COM	031162900	4,401	301	SH	Call	DFND	1	0	301	0
AMGEN INC	COM	031162950	54,010	3,694	SH	Put	DFND	1	0	3,694	0
AMICUS THERAPEUTICS INC	COM	03152W109	300	60,309	SH		DFND	1	0	60,309	0
AMICUS THERAPEUTICS INC	COM	03152W909	5,077	10,216	SH	Call	DFND	1	0	10,216	0
AMICUS THERAPEUTICS INC	COM	03152W959	567	1,140	SH	Put	DFND	1	0	1,140	0
AMPLIPHI BIOSCIENCES CORP	COM	03211P202	668	1,518,814	SH		DFND	1	0	1,518,814	0
ANTHERA PHARMACEUTICALS INC	COM	03674U201	59	91,055	SH		DFND	1	0	91,055	0
ANTHERA PHARMACEUTICALS INC	COM	03674U901	64	987	SH	Call	DFND	1	0	987	0
APPLIED DNA SCIENCES	*W	03815U110	1,139	2,277,612	SH		DFND	1	0	2,277,612	0
APPLIED DNA SCIENCES	COM	03815U201	3,903	2,109,601	SH		DFND	1	0	2,109,601	0
ARBUTUS BIOPHARMA CORP	COM	03879J100	1,942	792,617	SH		DFND	1	0	792,617	0
ARBUTUS BIOPHARMA CORP	COM	03879J900	498	2,033	SH	Call	DFND	1	0	2,033	0
ASTERIAS BIOTHERAPEUTICS INC	COM	04624N907	92	200	SH	Call	DFND	1	0	200	0
ASTRAZENECA PLC	ADR	004635308	12,985	4,753	SH	Call	DFND	1	0	4,753	0
ATHERSYS INC	COM	04744L106	66	43,263	SH		DFND	1	0	43,263	0
AXOVANT SCIENCES LTD	COM	G0750W104	1,254	100,998	SH		DFND	1	0	100,998	0
AXOVANT SCIENCES LTD	COM	G0750W904	7,112	5,726	SH	Call	DFND	1	0	5,726	0
AXOVANT SCIENCES LTD	COM	G0750W954	3,276	2,638	SH	Put	DFND	1	0	2,638	0
AZURRX BIOPHARMA INC.	COM	05502L105	564	118,993	SH		DFND	1	0	118,993	0
BARCLAYS BANK PLC	IPATH	06740Q260	1,743	50,000	SH		DFND	1	0	50,000	0
BELLEROPHON THERAPEUTICS INC	COM	078771102	414	789,857	SH		DFND	1	0	789,857	0
BENITEC BIOPHARMA LTD	*W	082053117	10	98,146	SH		DFND	1	0	98,146	0
BENITEC BIOPHARMA LTD	ADR	082053307	389	254,445	SH		DFND	1	0	254,445	0
BIO PATH HOLDINGS INC.	COM	09057N102	896	664,046	SH		DFND	1	0	664,046	0
BIOBLAST PHARMA LTD	SHS	M20156101	687	660,157	SH		DFND	1	0	660,157	0
BIOCEPT INC	COM	09072V204	319	411,432	SH		DFND	1	0	411,432	0
BIODELIVERY SCIENCES INTL INC.	COM	09060J106	1,222	698,235	SH		DFND	1	0	698,235	0
BIOGEN INC	COM	09062X103	5,672	20,000	SH		DFND	1	0	20,000	0
BIOGEN INC	COM	09062X903	3,261	115	SH	Call	DFND	1	0	115	0
BIOGEN INC	COM	09062X953	2,836	100	SH	Put	DFND	1	0	100	0
BIOPHARMX CORP	COM	09072X101	265	708,046	SH		DFND	1	0	708,046	0
BLUEBIRD BIO INC	COM	09609G900	3,665	597	SH	Call	DFND	1	0	597	0
BLUEPRINT MEDICINES CORP	COM	09627Y959	533	190	SH	Put	DFND	1	0	190	0
BRAINSTORM CELL THERAPEUTICS	COM	10501E201	637	250,766	SH		DFND	1	0	250,766	0
BRISTOL MYERS SQUIBB CO	COM	110122108	16,900	289,183	SH		DFND	1	0	289,183	0
BRISTOL MYERS SQUIBB CO	COM	110122908	31,669	5,419	SH	Call	DFND	1	0	5,419	0
BRISTOL MYERS SQUIBB CO	COM	110122958	49,545	8,478	SH	Put	DFND	1	0	8,478	0
CANCER GENETICS INC	COM	13739U104	97	71,971	SH		DFND	1	0	71,971	0
CAPNIA INC	COM	14066L105	145	179,002	SH		DFND	1	0	179,002	0
CAPRICOR THERAPEUTICS INC	COM	14070B101	990	372,046	SH		DFND	1	0	372,046	0
CARDIOME PHARMA CORP	COM	14159U301	1,208	437,720	SH		DFND	1	0	437,720	0
CEL SCI CORP	COM	150837508	427	6,360,207	SH		DFND	1	0	6,360,207	0
CELLECT BIOTECHNOLOGY LTD	ADS	15116C102	177	57,348	SH		DFND	1	0	57,348	0
CELLECTAR BIOSCIENCES INC	*W	15117F120	85	201,889	SH		DFND	1	0	201,889	0
CELLECTAR BIOSCIENCES INC	COM	15117F302	395	323,515	SH		DFND	1	0	323,515	0
CELSION CORP	COM	15117N404	416	1,333,093	SH		DFND	1	0	1,333,093	0
CEMPRA INC	COM	15130J109	121	43,121	SH		DFND	1	0	43,121	0
CHAMPIONS ONCOLOGY INC	COM	15870P307	641	253,504	SH		DFND	1	0	253,504	0
CHECK CAP LTD	SHS	M2361E112	1,352	575,113	SH		DFND	1	0	575,113	0
CHIMERIX INC	COM	16934W106	368	79,900	SH		DFND	1	0	79,900	0
CIDARA THERAPEUTICS INC	COM	171757107	3,041	292,398	SH		DFND	1	0	292,398	0
CLOVIS ONCOLOGY INC	COM	189464900	15,005	3,378	SH	Call	DFND	1	0	3,378	0
CLOVIS ONCOLOGY INC	COM	189464950	1,866	420	SH	Put	DFND	1	0	420	0
COHERUS BIOSCIENCES INC	COM	19249H103	806	28,618	SH		DFND	1	0	28,618	0
COHERUS BIOSCIENCES INC	COM	19249H953	2,567	912	SH	Put	DFND	1	0	912	0
COMBIMATRIX CORP	*W	20009T147	363	844,917	SH		DFND	1	0	844,917	0
CYTORI THERAPEUTICS INC	*W	23283K121	866	1,273,712	SH		DFND	1	0	1,273,712	0
CYTORI THERAPEUTICS INC	COM	23283K204	2,494	1,651,835	SH		DFND	1	0	1,651,835	0
CYTRX CORP	COM	232828509	1,749	4,697,802	SH		DFND	1	0	4,697,802	0
DEPOMED INC	COM	249908904	335	186	SH	Call	DFND	1	0	186	0
DEXTERA SURGICAL INC	COM	252366109	382	397,863	SH		DFND	1	0	397,863	0
DICERNA PHARMACEUTICALS INC	COM	253031108	288	100,000	SH		DFND	1	0	100,000	0
DURECT CORP	COM	266605104	2,048	1,528,516	SH		DFND	1	0	1,528,516	0
DURECT CORP	COM	266605904	928	6,927	SH	Call	DFND	1	0	6,927	0
DYNAVAX TECHNOLOGIES CORP	COM	268158201	261	66,091	SH		DFND	1	0	66,091	0
DYNAVAX TECHNOLOGIES CORP	COM	268158901	782	1,979	SH	Call	DFND	1	0	1,979	0
DYNAVAX TECHNOLOGIES CORP	COM	268158951	102	258	SH	Put	DFND	1	0	258	0
EDAP TMS S A	ADR	268311107	76	22,993	SH		DFND	1	0	22,993	0
EDAP TMS S A	ADR	268311957	112	341	SH	Put	DFND	1	0	341	0
EDITAS MEDICINE INC.	COM	28106W103	1,866	115,000	SH		DFND	1	0	115,000	0
EIGER BIOPHARMACEUTICALS INC	COM	28249U105	2,802	240,541	SH		DFND	1	0	240,541	0
ELI LILLY & CO	COM	532457108	15,674	213,113	SH		DFND	1	0	213,113	0
ELI LILLY & CO	COM	532457908	174,130	23,675	SH	Call	DFND	1	0	23,675	0
ELI LILLY & CO	COM	532457958	29,736	4,043	SH	Put	DFND	1	0	4,043	0
ENDO INTERNATIONAL PLC	SHS	G30401106	2,078	126,139	SH		DFND	1	0	126,139	0
ENDO INTERNATIONAL PLC	SHS	G30401956	2,179	1,323	SH	Put	DFND	1	0	1,323	0
ENTEROMEDICS INC	COM	29365M505	67	33,387	SH		DFND	1	0	33,387	0
EXELIXIS INC	COM	30161Q904	2,658	1,783	SH	Call	DFND	1	0	1,783	0
EXELIXIS INC	COM	30161Q954	8,039	5,392	SH	Put	DFND	1	0	5,392	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G108	1,616	23,494	SH		DFND	1	0	23,494	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G908	19,928	2,897	SH	Call	DFND	1	0	2,897	0
EXPRESS SCRIPTS HOLDING CO	COM	30219G958	8,193	1,191	SH	Put	DFND	1	0	1,191	0
EYEGATE PHARMACEUTICALS INC	COM	30233M107	314	192,721	SH		DFND	1	0	192,721	0
EYEGATE PHARMACEUTICALS INC	*W	30233M115	6	20,604	SH		DFND	1	0	20,604	0
FIBROGEN INC	COM	31572Q908	2,544	1,189	SH	Call	DFND	1	0	1,189	0
FLEXION THERAPEUTICS INC	COM	33938J106	208	10,914	SH		DFND	1	0	10,914	0
FLEXION THERAPEUTICS INC	COM	33938J906	240	126	SH	Call	DFND	1	0	126	0
FLEXION THERAPEUTICS INC	COM	33938J956	472	248	SH	Put	DFND	1	0	248	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135105	648	58,338	SH		DFND	1	0	58,338	0
FOAMIX PHARMACEUTICALS LTD	SHS	M46135905	978	881	SH	Call	DFND	1	0	881	0
FORWARD PHARMA A/S	ADR	34986J105	1,565	104,273	SH		DFND	1	0	104,273	0
GALECTIN THERAPEUTICS INC	COM	363225952	23	235	SH	Put	DFND	1	0	235	0
GALENA BIOPHARMA INC	COM	363256504	45	23,298	SH		DFND	1	0	23,298	0
GALENA BIOPHARMA INC	COM	363256954	164	847	SH	Put	DFND	1	0	847	0
GENETIC TECHNOLOGIES LTD	SHS	37185R208	1,156	1,070,333	SH		DFND	1	0	1,070,333	0
GENVEC INC	COM	37246C406	387	120,544	SH		DFND	1	0	120,544	0
GILEAD SCIENCES INC	COM	375558903	30,914	4,317	SH	Call	DFND	1	0	4,317	0
GREAT PANTHER SILVER LTD	COM	39115V951	45	269	SH	Put	DFND	1	0	269	0
GW PHARMACEUTICALS PLC	ADS	36197T903	2,615	234	SH	Call	DFND	1	0	234	0
GW PHARMACEUTICALS PLC	ADS	36197T953	2,146	192	SH	Put	DFND	1	0	192	0
HALOZYME THERAPEUTICS INC	COM	40637H909	2,676	2,708	SH	Call	DFND	1	0	2,708	0
HALOZYME THERAPEUTICS INC	COM	40637H959	526	532	SH	Put	DFND	1	0	532	0
HCA HOLDINGS INC	COM	40412C901	48,046	6,491	SH	Call	DFND	1	0	6,491	0
HCA HOLDINGS INC	COM	40412C951	740	100	SH	Put	DFND	1	0	100	0
HEMISPHERX BIOPHARMA INC	COM	42366C301	960	1,391,286	SH		DFND	1	0	1,391,286	0
HERON THERAPEUTICS INC	COM	427746902	185	141	SH	Call	DFND	1	0	141	0
HESS CORP	COM	42809H907	5,619	902	SH	Call	DFND	1	0	902	0
HISTOGENICS CORP	COM	43358V109	1,578	944,891	SH		DFND	1	0	944,891	0
HORIZON PHARMA PLC	SHS	G4617B905	9,647	5,962	SH	Call	DFND	1	0	5,962	0
HORIZON PHARMA PLC	SHS	G4617B955	4,516	2,791	SH	Put	DFND	1	0	2,791	0
HUMANA INC	COM	444859902	5,937	291	SH	Call	DFND	1	0	291	0
IGNYTA INC	COM	451731103	1,034	195,000	SH		DFND	1	0	195,000	0
IMMUNOCELLULAR THERAPEUTICS	*W	452536121	192	383,471	SH		DFND	1	0	383,471	0
IMMUNOCELLULAR THERAPEUTICS	COM	452536204	328	160,129	SH		DFND	1	0	160,129	0
IMMUNOMEDICS INC	COM	452907108	184	50,000	SH		DFND	1	0	50,000	0
INOTEK PHARMACEUTICALS CORP	COM	45780V102	921	150,930	SH		DFND	1	0	150,930	0
INOTEK PHARMACEUTICALS CORP	COM	45780V902	65	106	SH	Call	DFND	1	0	106	0
INOTEK PHARMACEUTICALS CORP	COM	45780V952	305	500	SH	Put	DFND	1	0	500	0
INSMED INC	COM	457669307	636	48,043	SH		DFND	1	0	48,043	0
INSMED INC	COM	457669907	1,930	1,459	SH	Call	DFND	1	0	1,459	0
INSMED INC	COM	457669957	2,531	1,913	SH	Put	DFND	1	0	1,913	0
INSPIREMD INC	*W	45779A127	726	1,210,106	SH		DFND	1	0	1,210,106	0
INTEC PHARMA LTD	SHS	M53644106	2,930	514,100	SH		DFND	1	0	514,100	0
INTELLIA THERAPEUTICS INC	COM	45826J105	1,704	130,000	SH		DFND	1	0	130,000	0
INTRA-CELLULAR THERAPIES INC	COM	46116X901	2,688	1,781	SH	Call	DFND	1	0	1,781	0
IONIS PHARMACEUTICALS INC	COM	462222900	5,041	1,054	SH	Call	DFND	1	0	1,054	0
IONIS PHARMACEUTICALS INC	COM	462222950	3,525	737	SH	Put	DFND	1	0	737	0
ISHARES TR	ETF	464287955	100,045	7,419	SH	Put	DFND	1	0	7,419	0
JUNO THERAPEUTICS INC	COM	48205A909	194	103	SH	Call	DFND	1	0	103	0
KITE PHARMA INC	COM	49803L909	5,251	1,171	SH	Call	DFND	1	0	1,171	0
KITE PHARMA INC	COM	49803L959	1,305	291	SH	Put	DFND	1	0	291	0
LA JOLLA PHARMACEUTICAL CO	COM	503459604	3,698	210,978	SH		DFND	1	0	210,978	0
LA JOLLA PHARMACEUTICAL CO	COM	503459904	2,957	1,687	SH	Call	DFND	1	0	1,687	0
LA JOLLA PHARMACEUTICAL CO	COM	503459954	589	336	SH	Put	DFND	1	0	336	0
LEXICON PHARMACEUTICALS INC	COM	528872302	969	70,040	SH		DFND	1	0	70,040	0
LEXICON PHARMACEUTICALS INC	COM	528872902	2,162	1,563	SH	Call	DFND	1	0	1,563	0
LEXICON PHARMACEUTICALS INC	COM	528872952	167	121	SH	Put	DFND	1	0	121	0
LION BIOTECHNOLOGIES INC	COM	53619R102	1,571	226,081	SH		DFND	1	0	226,081	0
LION BIOTECHNOLOGIES INC	COM	53619R952	876	1,260	SH	Put	DFND	1	0	1,260	0
LION BIOTECHNOLOGIES INC	COM	53619R990	136	195	SH	Call	DFND	1	0	195	0
MANNKIND CORP	COM	56400P951	499	7,842	SH	Put	DFND	1	0	7,842	0
MEDICINES CO	COM	584688105	3,815	112,392	SH		DFND	1	0	112,392	0
MEDICINES CO	COM	584688905	1,551	457	SH	Call	DFND	1	0	457	0
MEDICINES CO	COM	584688955	3,978	1,172	SH	Put	DFND	1	0	1,172	0
MEDIGUS LTD	ADR	58471G102	50	87,876	SH		DFND	1	0	87,876	0
MERCK & CO	COM	58933Y905	74,459	12,648	SH	Call	DFND	1	0	12,648	0
MIRATI THERAPEUTICS INC	COM	60468T105	474	99,735	SH		DFND	1	0	99,735	0
MIRNA THERAPEUTICS INC	COM	60470J103	180	100,200	SH		DFND	1	0	100,200	0
MONSANTO CO	COM	61166W901	3,293	313	SH	Call	DFND	1	0	313	0
MOTIF BIO PLC	COM	619784101	5,121	847,826	SH		DFND	1	0	847,826	0
MOTIF BIO PLC	*W	619784119	550	426,170	SH		DFND	1	0	426,170	0
MYLAN N.V.	SHS	N59465909	15,878	4,162	SH	Call	DFND	1	0	4,162	0
NEKTAR THERAPEUTICS	COM	640268908	135	110	SH	Call	DFND	1	0	110	0
NEURALSTEM INC	COM	64127R302	63	229,521	SH		DFND	1	0	229,521	0
NEUROCRINE BIOSCIENCES INC	COM	64125C909	4,462	1,153	SH	Call	DFND	1	0	1,153	0
NEURODERM LTD	SHS	M74231107	511	23,033	SH		DFND	1	0	23,033	0
NEUROMETRIX INC	*W	641255153	211	3,017,747	SH		DFND	1	0	3,017,747	0
NEUROMETRIX INC	COM	641255500	123	166,268	SH		DFND	1	0	166,268	0
NEVRO CORP	COM	64157F903	1,199	165	SH	Call	DFND	1	0	165	0
NEWLINK GENETICS CORP	COM	651511107	579	56,289	SH		DFND	1	0	56,289	0
NEWLINK GENETICS CORP	COM	651511907	1,624	1,580	SH	Call	DFND	1	0	1,580	0
NIVALIS THERAPEUTICS INC	COM	65481J109	90	40,004	SH		DFND	1	0	40,004	0
NOVAVAX INC	COM	670002904	20	159	SH	Call	DFND	1	0	159	0
OCERA THERAPEUTICS INC	COM	67552A108	690	328,632	SH		DFND	1	0	328,632	0
OHR PHARMACEUTICAL INC	COM	67778H200	1,735	1,156,393	SH		DFND	1	0	1,156,393	0
ONCOBIOLOGICS INC	COM	68235M105	6,738	2,238,470	SH		DFND	1	0	2,238,470	0
ONCOBIOLOGICS INC	*W	68235M113	154	930,592	SH		DFND	1	0	930,592	0
ONCOBIOLOGICS INC	*W	68235M121	726	930,272	SH		DFND	1	0	930,272	0
ONCONOVA THERAPEUTICS INC	*W	68232V116	428	691,072	SH		DFND	1	0	691,072	0
ONCONOVA THERAPEUTICS INC	COM	68232V306	1,028	452,804	SH		DFND	1	0	452,804	0
ONCOSEC MEDICAL INC	COM	68234L207	1,444	1,173,946	SH		DFND	1	0	1,173,946	0
OPGEN INC	COM	68373L109	604	525,146	SH		DFND	1	0	525,146	0
OPHTHOTECH CORP	COM	683745903	426	883	SH	Call	DFND	1	0	883	0
OPKO HEALTH INC	COM	68375N103	1,776	190,955	SH		DFND	1	0	190,955	0
OPKO HEALTH INC	COM	68375N903	1,387	1,491	SH	Call	DFND	1	0	1,491	0
OPKO HEALTH INC	COM	68375N953	2,116	2,275	SH	Put	DFND	1	0	2,275	0
OTONOMY ORD SHS	COM	68906L105	159	10,000	SH		DFND	1	0	10,000	0
OVASCIENCE INC	COM	69014Q101	74	48,450	SH		DFND	1	0	48,450	0
PACIRA PHARMACEUTICALS INC	COM	695127900	2,261	700	SH	Call	DFND	1	0	700	0
PACIRA PHARMACEUTICALS INC	COM	695127950	514	159	SH	Put	DFND	1	0	159	0
PALATIN TECHNOLOGIES INC	COM	696077403	853	1,672,573	SH		DFND	1	0	1,672,573	0
PARATEK PHARMACEUTICALS INC	COM	699374302	1,694	110,000	SH		DFND	1	0	110,000	0
PARNELL PHARMACEUTICALS HOLDINGS LTD	COM	Q73622104	138	200,549	SH		DFND	1	0	200,549	0
PIERIS PHARMACEUTICALS INC	COM	720795103	1,814	1,296,034	SH		DFND	1	0	1,296,034	0
PORTOLA PHARMACEUTICALS INC	COM	737010908	4,046	1,803	SH	Call	DFND	1	0	1,803	0
PORTOLA PHARMACEUTICALS INC	COM	737010958	240	107	SH	Put	DFND	1	0	107	0
PRONAI THERAPEUTICS INC.	COM	74346L101	1,402	940,841	SH		DFND	1	0	940,841	0
PROQR THERAPEUTICS N V	SHS	N71542109	196	40,000	SH		DFND	1	0	40,000	0
PROTHENA CORPORATION PLC	COM	G72800908	2,410	490	SH	Call	DFND	1	0	490	0
PSIVIDA CORP	COM	74440J101	351	205,100	SH		DFND	1	0	205,100	0
PTC THERAPEUTICS INC	COM	69366J900	6,481	5,940	SH	Call	DFND	1	0	5,940	0
PTC THERAPEUTICS INC	COM	69366J950	651	597	SH	Put	DFND	1	0	597	0
PUMA BIOTECHNOLOGY INC	COM	74587V107	3,170	103,243	SH		DFND	1	0	103,243	0
PUMA BIOTECHNOLOGY INC	COM	74587V907	6,683	2,177	SH	Call	DFND	1	0	2,177	0
PUMA BIOTECHNOLOGY INC	COM	74587V957	5,216	1,699	SH	Put	DFND	1	0	1,699	0
RADIUS HEALTH INC	COM	750469957	4,526	1,190	SH	Put	DFND	1	0	1,190	0
REDHILL BIOPHARMA LTD	ADS	757468103	2,006	191,785	SH		DFND	1	0	191,785	0
REGENERON PHARMACEUTICALS INC	COM	75886F107	59,658	162,517	SH		DFND	1	0	162,517	0
REGENERON PHARMACEUTICALS INC	COM	75886F907	7,415	202	SH	Call	DFND	1	0	202	0
REGENERON PHARMACEUTICALS INC	COM	75886F957	80,686	2,198	SH	Put	DFND	1	0	2,198	0
REGENXBIO INC	COM	75901B107	898	48,400	SH		DFND	1	0	48,400	0
RENNOVA HEALTH INC	COM	759757107	167	2,022,213	SH		DFND	1	0	2,022,213	0
RENNOVA HEALTH INC	*W	759757123	118	4,926,013	SH		DFND	1	0	4,926,013	0
RETROPHIN INC	COM	761299906	9,083	4,798	SH	Call	DFND	1	0	4,798	0
RETROPHIN INC	COM	761299956	772	408	SH	Put	DFND	1	0	408	0
REXAHN PHARMACEUTICALS INC	COM	761640101	1,040	7,326,681	SH		DFND	1	0	7,326,681	0
RICEBRAN TECHNOLOGIES	COM	762831204	902	875,286	SH		DFND	1	0	875,286	0
RIGEL PHARMACEUTICALS INC	COM	766559603	29	12,350	SH		DFND	1	0	12,350	0
ROKA BIOSCIENCE INC	COM	775431208	1,549	365,220	SH		DFND	1	0	365,220	0
ROSETTA GENOMICS LTD	SHS	M82183126	248	591,339	SH		DFND	1	0	591,339	0
RXI PHARMACEUTICALS CORP	*W	74979C113	454	2,270,283	SH		DFND	1	0	2,270,283	0
RXI PHARMACEUTICALS CORP	COM	74979C501	284	397,371	SH		DFND	1	0	397,371	0
SAGE THERAPEUTICS INC	COM	78667J908	4,335	849	SH	Call	DFND	1	0	849	0
SAGE THERAPEUTICS INC	COM	78667J958	521	102	SH	Put	DFND	1	0	102	0
SANGAMO BIOSCIENCES INC	COM	800677106	193	63,204	SH		DFND	1	0	63,204	0
SANGAMO BIOSCIENCES INC	COM	800677906	1,884	6,177	SH	Call	DFND	1	0	6,177	0
SAREPTA THERAPEUTICS INC	COM	803607100	55,266	2,014,787	SH		DFND	1	0	2,014,787	0
SAREPTA THERAPEUTICS INC	COM	803607900	1,676	611	SH	Call	DFND	1	0	611	0
SAREPTA THERAPEUTICS INC	COM	803607950	52,805	19,251	SH	Put	DFND	1	0	19,251	0
SIENTRA INC	COM	82621J105	605	70,973	SH		DFND	1	0	70,973	0
SIENTRA INC	COM	82621J955	2,056	2,413	SH	Put	DFND	1	0	2,413	0
SOPHIRIS BIO INC	COM	83578Q209	1,391	496,729	SH		DFND	1	0	496,729	0
SPDR S&P 500 ETF TR	ETF	78462F953	134,118	6,000	SH	Put	DFND	1	0	6,000	0
SPDR S&P BIOTECH ETF	ETF	78464A870	693	11,700	SH		DFND	1	0	11,700	0
SPDR S&P BIOTECH ETF	ETF	78464A950	27,364	4,623	SH	Put	DFND	1	0	4,623	0
STEMLINE THERAPEUTICS INC	COM	85858C107	3,829	357,806	SH		DFND	1	0	357,806	0
STEMLINE THERAPEUTICS INC	COM	85858C907	381	356	SH	Call	DFND	1	0	356	0
STRATA SKIN SCIENCES INC	COM	86272A107	455	1,034,820	SH		DFND	1	0	1,034,820	0
SUCAMPO PHARMACEUTICALS INC	CL A	864909106	1,016	75,000	SH		DFND	1	0	75,000	0
SUNESIS PHARMACEUTICALS INC	COM	867328700	801	221,326	SH		DFND	1	0	221,326	0
SUPERCONDUCTOR TECHNOLOGIES	COM	867931503	535	434,747	SH		DFND	1	0	434,747	0
SYNERGY PHARMACEUTICALS INC	COM	871639908	4,589	7,536	SH	Call	DFND	1	0	7,536	0
SYNTHETIC BIOLOGICS INC	COM	87164U102	2,312	3,031,953	SH		DFND	1	0	3,031,953	0
TENAX THERAPEUTICS INC	COM	88032L100	2,958	1,516,835	SH		DFND	1	0	1,516,835	0
TENAX THERAPEUTICS INC	COM	88032L900	2,386	12,237	SH	Call	DFND	1	0	12,237	0
TENAX THERAPEUTICS INC	COM	88032L950	33	169	SH	Put	DFND	1	0	169	0
TESARO INC	COM	881569907	25,094	1,866	SH	Call	DFND	1	0	1,866	0
TESARO INC	COM	881569957	7,571	563	SH	Put	DFND	1	0	563	0
TEVA PHARMACEUTICAL INDUSTRIES LTD	ADR	881624909	31,313	8,638	SH	Call	DFND	1	0	8,638	0
TG THERAPEUTICS INC	COM	88322Q958	394	848	SH	Put	DFND	1	0	848	0
THERAPEUTICSMD INC	COM	88338N107	144	24,955	SH		DFND	1	0	24,955	0
THERAPEUTICSMD INC	COM	88338N907	406	703	SH	Call	DFND	1	0	703	0
THERAPEUTICSMD INC	COM	88338N957	338	586	SH	Put	DFND	1	0	586	0
UNITED THERAPEUTICS CORP	COM	91307C902	3,772	263	SH	Call	DFND	1	0	263	0
UNITED THERAPEUTICS CORP	COM	91307C952	15,777	1,100	SH	Put	DFND	1	0	1,100	0
VANDA PHARMACEUTICALS INC	COM	921659908	802	503	SH	Call	DFND	1	0	503	0
VERACYTE INC	COM	92337F107	1,502	193,999	SH		DFND	1	0	193,999	0
VERICEL INC	COM	92346J108	450	149,900	SH		DFND	1	0	149,900	0
VERTEX PHARMACEUTICALS INC	COM	92532F900	7,883	1,070	SH	Call	DFND	1	0	1,070	0
VERTEX PHARMACEUTICALS INC	COM	92532F950	2,181	296	SH	Put	DFND	1	0	296	0
VIKING THERAPEUTICS INC	*W	92686J114	39	86,349	SH		DFND	1	0	86,349	0
VISTAGEN THERAPEUTICS INC	COM	92840H202	658	176,384	SH		DFND	1	0	176,384	0
VTV THERAPEUTICS INC	CL A	918385105	640	132,547	SH		DFND	1	0	132,547	0
WAFERGEN BIO SYSTEMS INC	COM	93041P506	1,771	358,535	SH		DFND	1	0	358,535	0
WINDTREE THERAPEUTICS INC	COM	97382D105	415	334,414	SH		DFND	1	0	334,414	0
XTL BIOPHARMACEUTICALS LTD	ADR	98386D208	434	724,134	SH		DFND	1	0	724,134	0
ZAFGEN INC.	COM	98885E103	986	310,000	SH		DFND	1	0	310,000	0
ZOGENIX INC	COM	98978L904	15,025	12,366	SH	Call	DFND	1	0	12,366	0
ZOGENIX INC	COM	98978L954	165	136	SH	Put	DFND	1	0	136	0
ZOSANO PHARMA ORD SHS	COM	98979H103	81	103,600	SH		DFND	1	0	103,600	0