| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y909 | 94,858 | 10,675 | SH | Call | DFND | 1 | 0 | 10,675 | 0 |
| ACHILLION PHARMACEUTICALS INC | COM | 00448Q901 | 445 | 992 | SH | Call | DFND | 1 | 0 | 992 | 0 |
| ACTINIUM PHARMACEUTICALS INC. | COM | 00507W107 | 1,400 | 2,434,103 | SH | | DFND | 1 | 0 | 2,434,103 | 0 |
| ADAMIS PHARMACEUTICALS INC | COM | 00547W958 | 300 | 574 | SH | Put | DFND | 1 | 0 | 574 | 0 |
| ADAMIS PHARMACEUTICALS INC | COM | 00547W208 | 524 | 100,378 | SH | | DFND | 1 | 0 | 100,378 | 0 |
| ADVAXIS INC | COM | 007624908 | 113 | 270 | SH | Call | DFND | 1 | 0 | 270 | 0 |
| ADVAXIS INC | COM | 007624208 | 157 | 37,634 | SH | | DFND | 1 | 0 | 37,634 | 0 |
| ADVAXIS INC | COM | 007624958 | 173 | 414 | SH | Put | DFND | 1 | 0 | 414 | 0 |
| AERIE PHARMACEUTICALS INC | COM | 00771V108 | 230 | 4,726 | SH | | DFND | 1 | 0 | 4,726 | 0 |
| AERIE PHARMACEUTICALS INC | COM | 00771V958 | 360 | 74 | SH | Put | DFND | 1 | 0 | 74 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q957 | 37,186 | 3,165 | SH | Put | DFND | 1 | 0 | 3,165 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q907 | 54,985 | 4,680 | SH | Call | DFND | 1 | 0 | 4,680 | 0 |
| AMAG PHARMACEUTICALS INC | COM | 00163U906 | 469 | 254 | SH | Call | DFND | 1 | 0 | 254 | 0 |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 1,478 | 80,108 | SH | | DFND | 1 | 0 | 80,108 | 0 |
| AMAG PHARMACEUTICALS INC | COM | 00163U956 | 5,542 | 3,004 | SH | Put | DFND | 1 | 0 | 3,004 | 0 |
| AMARIN CORPORATION PLC | COM | 023111906 | 4,428 | 12,650 | SH | Call | DFND | 1 | 0 | 12,650 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W959 | 754 | 500 | SH | Put | DFND | 1 | 0 | 500 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W909 | 6,240 | 4,138 | SH | Call | DFND | 1 | 0 | 4,138 | 0 |
| AMPLIPHI BIOSCIENCES CORP. | COM | 03211P301 | 136 | 149,248 | SH | | DFND | 1 | 0 | 149,248 | 0 |
| ANTARES PHARMA INC | COM | 036642956 | 74 | 227 | SH | Put | DFND | 1 | 0 | 227 | 0 |
| ANTARES PHARMA INC | COM | 036642906 | 329 | 1,016 | SH | Call | DFND | 1 | 0 | 1,016 | 0 |
| ANTHERA PHARMACEUTICALS INC | COM | 03674U300 | 75 | 52,046 | SH | | DFND | 1 | 0 | 52,046 | 0 |
| APPLIED DNA SCIENCES INC | *W | 03815U110 | 575 | 857,768 | SH | | DFND | 1 | 0 | 857,768 | 0 |
| ARCA BIOPHARMA INC | COM | 00211Y407 | 110 | 100,000 | SH | | DFND | 1 | 0 | 100,000 | 0 |
| ASTRAZENECA PLC | ADR | 046353958 | 6,922 | 2,043 | SH | Put | DFND | 1 | 0 | 2,043 | 0 |
| ASTRAZENECA PLC | ADR | 046353908 | 15,209 | 4,489 | SH | Call | DFND | 1 | 0 | 4,489 | 0 |
| AXOVANT SCIENCES LTD | COM | G0750W904 | 874 | 1,270 | SH | Call | DFND | 1 | 0 | 1,270 | 0 |
| AXOVANT SCIENCES LTD | COM | G0750W104 | 4,421 | 642,557 | SH | | DFND | 1 | 0 | 642,557 | 0 |
| AXOVANT SCIENCES LTD | COM | G0750W954 | 5,283 | 7,679 | SH | Put | DFND | 1 | 0 | 7,679 | 0 |
| BARCLAYS BANK PLC | IPATH | 06740Q260 | 551 | 26,500 | SH | | DFND | 1 | 0 | 26,500 | 0 |
| BENITEC BIOPHARMA LTD | *W | 082053117 | 27 | 90,193 | SH | | DFND | 1 | 0 | 90,193 | 0 |
| BIOAMBER INC | COM | 09072Q106 | 1,559 | 3,180,973 | SH | | DFND | 1 | 0 | 3,180,973 | 0 |
| BIONDVAX PHARMACEUTICALS LTD | ADR | 09073Q105 | 139 | 19,376 | SH | | DFND | 1 | 0 | 19,376 | 0 |
| BLUEBIRD BIO INC | COM | 09609G950 | 7,760 | 565 | SH | Put | DFND | 1 | 0 | 565 | 0 |
| BLUEBIRD BIO INC | COM | 09609G900 | 53,992 | 3,931 | SH | Call | DFND | 1 | 0 | 3,931 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122908 | 26,962 | 4,230 | SH | Call | DFND | 1 | 0 | 4,230 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122108 | 62,654 | 982,955 | SH | | DFND | 1 | 0 | 982,955 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122958 | 210,782 | 33,069 | SH | Put | DFND | 1 | 0 | 33,069 | 0 |
| CEL SCI CORP. | COM | 150837607 | 976 | 587,822 | SH | | DFND | 1 | 0 | 587,822 | 0 |
| CELSION CORP. | COM | 15117N503 | 101 | 67,403 | SH | | DFND | 1 | 0 | 67,403 | 0 |
| CHECK CAP LTD | SHS | M2361E112 | 2,121 | 1,184,917 | SH | | DFND | 1 | 0 | 1,184,917 | 0 |
| CHF SOLUTIONS INC | COM | 12542Q102 | 216 | 367,893 | SH | | DFND | 1 | 0 | 367,893 | 0 |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 521 | 64,300 | SH | | DFND | 1 | 0 | 64,300 | 0 |
| CIGNA CORP | COM | 125509909 | 12,525 | 670 | SH | Call | DFND | 1 | 0 | 670 | 0 |
| CLOVIS ONCOLOGY INC | COM | 189464900 | 9,163 | 1,112 | SH | Call | DFND | 1 | 0 | 1,112 | 0 |
| CONTRAFECT CORP. | COM | 212326102 | 132 | 119,156 | SH | | DFND | 1 | 0 | 119,156 | 0 |
| CORMEDIX INC | COM | 21900C100 | 337 | 648,955 | SH | | DFND | 1 | 0 | 648,955 | 0 |
| CYTOKINETICS INC | COM | 23282W955 | 344 | 237 | SH | Put | DFND | 1 | 0 | 237 | 0 |
| CYTOKINETICS INC | COM | 23282W905 | 4,927 | 3,398 | SH | Call | DFND | 1 | 0 | 3,398 | 0 |
| CYTORI THERAPEUTICS INC | *W | 23283K121 | 45 | 1,237,952 | SH | | DFND | 1 | 0 | 1,237,952 | 0 |
| CYTRX CORP | COM | 232828959 | 4 | 100 | SH | Put | DFND | 1 | 0 | 100 | 0 |
| DBV TECHNOLOGIES SA | ADR | 23306J951 | 7,571 | 1,784 | SH | Put | DFND | 1 | 0 | 1,784 | 0 |
| DBV TECHNOLOGIES SA | ADR | 23306J901 | 46,294 | 10,908 | SH | Call | DFND | 1 | 0 | 10,908 | 0 |
| DELMAR PHARMACEUTICALS INC. | COM | 247078207 | 1,782 | 2,121,202 | SH | | DFND | 1 | 0 | 2,121,202 | 0 |
| EDAP TMS SA | ADR | 268311957 | 663 | 2,224 | SH | Put | DFND | 1 | 0 | 2,224 | 0 |
| EGALET CORP | COM | 28226B104 | 923 | 721,050 | SH | | DFND | 1 | 0 | 721,050 | 0 |
| EIGER BIOPHARMACEUTICALS | COM | 28249U105 | 1,018 | 92,500 | SH | | DFND | 1 | 0 | 92,500 | 0 |
| EKSO BIONICS HOLDINGS INC | COM | 282644202 | 850 | 702,364 | SH | | DFND | 1 | 0 | 702,364 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W105 | 4,178 | 83,357 | SH | | DFND | 1 | 0 | 83,357 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W955 | 7,413 | 1,479 | SH | Put | DFND | 1 | 0 | 1,479 | 0 |
| EYEGATE PHARMACEUTICALS INC | COM | 30233M107 | 54 | 46,378 | SH | | DFND | 1 | 0 | 46,378 | 0 |
| FIBROGEN INC | COM | 31572Q908 | 7,446 | 1,384 | SH | Call | DFND | 1 | 0 | 1,384 | 0 |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X954 | 3,101 | 758 | SH | Put | DFND | 1 | 0 | 758 | 0 |
| FLEXION THERAPEUTICS INC | COM | 33938J956 | 706 | 292 | SH | Put | DFND | 1 | 0 | 292 | 0 |
| FLEXION THERAPEUTICS INC | COM | 33938J906 | 825 | 341 | SH | Call | DFND | 1 | 0 | 341 | 0 |
| FUELCELL ENERGY INC | COM | 35952H502 | 21 | 11,968 | SH | | DFND | 1 | 0 | 11,968 | 0 |
| FUELCELL ENERGY INC | COM | 35952H952 | 42 | 239 | SH | Put | DFND | 1 | 0 | 239 | 0 |
| GALECTIN THERAPEUTICS INC | COM | 363225952 | 72 | 337 | SH | Put | DFND | 1 | 0 | 337 | 0 |
| GALENA BIOPHARMA INC | COM | 363256904 | 215 | 6,084 | SH | Call | DFND | 1 | 0 | 6,084 | 0 |
| GALENA BIOPHARMA INC | COM | 363256504 | 953 | 2,702,228 | SH | | DFND | 1 | 0 | 2,702,228 | 0 |
| GEVO INC | COM | 374396307 | 140 | 224,810 | SH | | DFND | 1 | 0 | 224,810 | 0 |
| GILEAD SCIENCES INC | COM | 375558903 | 3,678 | 454 | SH | Call | DFND | 1 | 0 | 454 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U908 | 935 | 301 | SH | Call | DFND | 1 | 0 | 301 | 0 |
| GW PHARMACEUTICALS PLC | ADS | 36197T103 | 2,894 | 28,517 | SH | | DFND | 1 | 0 | 28,517 | 0 |
| GW PHARMACEUTICALS PLC | ADS | 36197T953 | 11,661 | 1,149 | SH | Put | DFND | 1 | 0 | 1,149 | 0 |
| HALOZYME THERAPEUTICS INC | COM | 40637H909 | 22,645 | 13,037 | SH | Call | DFND | 1 | 0 | 13,037 | 0 |
| HEAT BIOLOGICS INC | COM | 42237K102 | 1,118 | 1,712,481 | SH | | DFND | 1 | 0 | 1,712,481 | 0 |
| HISTOGENICS CORP | COM | 43358V109 | 954 | 481,667 | SH | | DFND | 1 | 0 | 481,667 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K906 | 93 | 416 | SH | Call | DFND | 1 | 0 | 416 | 0 |
| IDERA PHARMACEUTICALS INC | COM | 45168K306 | 346 | 155,027 | SH | | DFND | 1 | 0 | 155,027 | 0 |
| IMMUNOCELLULAR THERAPEUTICS | *W | 452536121 | 8 | 420,103 | SH | | DFND | 1 | 0 | 420,103 | 0 |
| IMMUNOMEDICS INC | COM | 452907908 | 1,848 | 1,322 | SH | Call | DFND | 1 | 0 | 1,322 | 0 |
| INCYTE CORP | COM | 45337C952 | 2,148 | 184 | SH | Put | DFND | 1 | 0 | 184 | 0 |
| INCYTE CORP | COM | 45337C902 | 4,459 | 382 | SH | Call | DFND | 1 | 0 | 382 | 0 |
| INSMED INC | COM | 457669907 | 4,291 | 1,375 | SH | Call | DFND | 1 | 0 | 1,375 | 0 |
| INSMED INC | COM | 457669957 | 5,777 | 1,851 | SH | Put | DFND | 1 | 0 | 1,851 | 0 |
| INSPIREMD EQUITY | *W | 45779A135 | 40 | 2,002,648 | SH | | DFND | 1 | 0 | 2,002,648 | 0 |
| INSPIREMD EQUITY | *W | 45779A127 | 41 | 1,194,322 | SH | | DFND | 1 | 0 | 1,194,322 | 0 |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | 280 | 11,281 | SH | | DFND | 1 | 0 | 11,281 | 0 |
| INTERCEPT PHARMACEUTICALS INC | COM | 45845P908 | 580 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222900 | 7,215 | 1,423 | SH | Call | DFND | 1 | 0 | 1,423 | 0 |
| IONIS PHARMACEUTICALS INC | COM | 462222950 | 8,173 | 1,612 | SH | Put | DFND | 1 | 0 | 1,612 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 88,612 | 5,980 | SH | Put | DFND | 1 | 0 | 5,980 | 0 |
| JAGUAR HEALTH | COM | 47010C201 | 437 | 2,185,555 | SH | | DFND | 1 | 0 | 2,185,555 | 0 |
| KADMON HOLDINGS INC | COM | 48283N106 | 1,761 | 525,695 | SH | | DFND | 1 | 0 | 525,695 | 0 |
| KITE PHARMA INC | COM | 49803L959 | 9,764 | 543 | SH | Put | DFND | 1 | 0 | 543 | 0 |
| KRYSTAL BIOTECH INC | COM | 501147102 | 534 | 53,558 | SH | | DFND | 1 | 0 | 53,558 | 0 |
| MANNKIND CORP | COM | 56400P906 | 375 | 1,727 | SH | Call | DFND | 1 | 0 | 1,727 | 0 |
| MANNKIND CORP | COM | 56400P956 | 1,312 | 6,048 | SH | Put | DFND | 1 | 0 | 6,048 | 0 |
| MEDICINES CO | COM | 584688905 | 244 | 66 | SH | Call | DFND | 1 | 0 | 66 | 0 |
| MEDIGUS LTD | ADR | 58471G201 | 578 | 258,095 | SH | | DFND | 1 | 0 | 258,095 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 26,758 | 4,179 | SH | Put | DFND | 1 | 0 | 4,179 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 282,622 | 44,139 | SH | Call | DFND | 1 | 0 | 44,139 | 0 |
| MICROBOT MED INC | COM | 59503A105 | 1,464 | 1,251,398 | SH | | DFND | 1 | 0 | 1,251,398 | 0 |
| NEUROMETRIX INC. | COM | 641255708 | 190 | 93,561 | SH | | DFND | 1 | 0 | 93,561 | 0 |
| NEWLINK GENETICS CORP | COM | 651511957 | 124 | 122 | SH | Put | DFND | 1 | 0 | 122 | 0 |
| NEWLINK GENETICS CORP | COM | 651511907 | 1,018 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| OASMIA PHARMACEUTICAL | ADR | 67421W109 | 20 | 19,000 | SH | | DFND | 1 | 0 | 19,000 | 0 |
| OHR PHARMACEUTICAL INC | COM | 67778H200 | 110 | 152,127 | SH | | DFND | 1 | 0 | 152,127 | 0 |
| ONCOBIOLOGICS INC | *W | 68235M121 | 13 | 260,018 | SH | | DFND | 1 | 0 | 260,018 | 0 |
| ONCOBIOLOGICS INC | *W | 68235M113 | 18 | 158,295 | SH | | DFND | 1 | 0 | 158,295 | 0 |
| ONCOBIOLOGICS INC | COM | 68235M105 | 3,266 | 2,383,971 | SH | | DFND | 1 | 0 | 2,383,971 | 0 |
| ONCONOVA THERAPEUTICS INC | *W | 68232V116 | 252 | 645,350 | SH | | DFND | 1 | 0 | 645,350 | 0 |
| ONCONOVA THERAPEUTICS INC | COM | 68232V306 | 1,438 | 840,960 | SH | | DFND | 1 | 0 | 840,960 | 0 |
| ONCOSEC MEDICAL INC | COM | 68234L207 | 968 | 1,010,143 | SH | | DFND | 1 | 0 | 1,010,143 | 0 |
| OPGEN INC | COM | 68373L109 | 514 | 1,659,500 | SH | | DFND | 1 | 0 | 1,659,500 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164302 | 42 | 19,700 | SH | | DFND | 1 | 0 | 19,700 | 0 |
| OREXIGEN THERAPEUTICS INC | COM | 686164952 | 42 | 197 | SH | Put | DFND | 1 | 0 | 197 | 0 |
| OTONOMY INC | COM | 68906L905 | 89 | 275 | SH | Call | DFND | 1 | 0 | 275 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 781 | 550,000 | SH | | DFND | 1 | 0 | 550,000 | 0 |
| PROTEOSTASIS THERAPEUTICS INC | COM | 74373B109 | 315 | 150,151 | SH | | DFND | 1 | 0 | 150,151 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800908 | 6,471 | 999 | SH | Call | DFND | 1 | 0 | 999 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J900 | 2,555 | 1,277 | SH | Call | DFND | 1 | 0 | 1,277 | 0 |
| REGENXBIO INC | COM | 75901B907 | 257 | 78 | SH | Call | DFND | 1 | 0 | 78 | 0 |
| RENNOVA HEALTH INC | COM | 759757602 | 91 | 466,880 | SH | | DFND | 1 | 0 | 466,880 | 0 |
| REXAHN PHARMACEUTICALS INC | COM | 761640200 | 411 | 169,901 | SH | | DFND | 1 | 0 | 169,901 | 0 |
| RICEBRAN TECHNOLOGIES | COM | 762831204 | 575 | 442,033 | SH | | DFND | 1 | 0 | 442,033 | 0 |
| RITTER PHARMACEUTICALS INC | COM | 767836109 | 1,630 | 4,657,800 | SH | | DFND | 1 | 0 | 1,357,800 | 0 |
| ROKA BIOSCIENCE INC | COM | 775431208 | 173 | 237,322 | SH | | DFND | 1 | 0 | 237,322 | 0 |
| ROSETTA GENOMICS LTD | SHS | M82183209 | 149 | 141,741 | SH | | DFND | 1 | 0 | 141,741 | 0 |
| RXI PHARMACEUTICALS CORP | *W | 74979C113 | 355 | 2,100,797 | SH | | DFND | 1 | 0 | 2,100,797 | 0 |
| SAGE THERAPEUTICS INC | COM | 78667J908 | 4,373 | 702 | SH | Call | DFND | 1 | 0 | 702 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677956 | 863 | 575 | SH | Put | DFND | 1 | 0 | 575 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677906 | 5,976 | 3,984 | SH | Call | DFND | 1 | 0 | 3,984 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 2,350 | 518 | SH | Put | DFND | 1 | 0 | 518 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 32,945 | 7,263 | SH | Call | DFND | 1 | 0 | 7,263 | 0 |
| SEATTLE GENETICS INC | COM | 812578102 | 2,320 | 42,646 | SH | | DFND | 1 | 0 | 42,646 | 0 |
| SEATTLE GENETICS INC | COM | 812578902 | 2,949 | 542 | SH | Call | DFND | 1 | 0 | 542 | 0 |
| SEATTLE GENETICS INC | COM | 812578952 | 9,435 | 1,734 | SH | Put | DFND | 1 | 0 | 1,734 | 0 |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 827 | 533,563 | SH | | DFND | 1 | 0 | 533,563 | 0 |
| SIGMA LABS INC | *W | 826598112 | 131 | 246,519 | SH | | DFND | 1 | 0 | 246,519 | 0 |
| SIGMA LABS INC | COM | 826598302 | 132 | 70,000 | SH | | DFND | 1 | 0 | 70,000 | 0 |
| SOPHIRIS BIO INC | COM | 83578Q959 | 24 | 112 | SH | Put | DFND | 1 | 0 | 112 | 0 |
| SOPHIRIS BIO INC | COM | 83578Q209 | 716 | 333,641 | SH | | DFND | 1 | 0 | 333,641 | 0 |
| SPDR S&P 500 ETF | TR | 78462F953 | 125,615 | 5,000 | SH | Put | DFND | 1 | 0 | 5,000 | 0 |
| STEMLINE THERAPEUTICS INC | COM | 85858C107 | 486 | 43,749 | SH | | DFND | 1 | 0 | 43,749 | 0 |
| STEMLINE THERAPEUTICS INC | COM | 85858C907 | 890 | 802 | SH | Call | DFND | 1 | 0 | 802 | 0 |
| STRATA SKIN SCIENCES INC | COM | 86272A206 | 375 | 211,695 | SH | | DFND | 1 | 0 | 211,695 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328700 | 473 | 243,638 | SH | | DFND | 1 | 0 | 243,638 | 0 |
| TESARO INC | COM | 881569107 | 452 | 3,500 | SH | | DFND | 1 | 0 | 3,500 | 0 |
| TESARO INC | COM | 881569907 | 1,291 | 100 | SH | Call | DFND | 1 | 0 | 100 | 0 |
| TESARO INC | COM | 881569957 | 1,343 | 104 | SH | Put | DFND | 1 | 0 | 104 | 0 |
| TRANSENTERIX INC | COM | 89366M951 | 490 | 3,426 | SH | Put | DFND | 1 | 0 | 3,426 | 0 |
| TROVAGENE INC | COM | 897238309 | 1,234 | 1,689,778 | SH | | DFND | 1 | 0 | 1,689,778 | 0 |
| UNITED THERAPEUTICS CORP | COM | 91307C902 | 6,352 | 542 | SH | Call | DFND | 1 | 0 | 542 | 0 |
| VERSARTIS INC | COM | 92529L902 | 155 | 632 | SH | Call | DFND | 1 | 0 | 632 | 0 |
| VERSARTIS INC | COM | 92529L102 | 1,733 | 707,300 | SH | | DFND | 1 | 0 | 707,300 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F950 | 19,111 | 1,257 | SH | Put | DFND | 1 | 0 | 1,257 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 43,559 | 2,865 | SH | Call | DFND | 1 | 0 | 2,865 | 0 |
| VTV THERAPEUTICS INC | CL A | 918385105 | 364 | 60,897 | SH | | DFND | 1 | 0 | 60,897 | 0 |
| WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 1,631 | 75,000 | SH | | DFND | 1 | 0 | 75,000 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 907 | 307,600 | SH | | DFND | 1 | 0 | 307,600 | 0 |
| ZOGENIX INC | COM | 98978L954 | 4,469 | 1,275 | SH | Put | DFND | 1 | 0 | 1,275 | 0 |
| ZOGENIX INC | COM | 98978L904 | 17,052 | 4,865 | SH | Call | DFND | 1 | 0 | 4,865 | 0 |
