| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBVIE INC | COM | 00287Y909 | 3,493 | 369 | SH | Call | DFND | 1 | 0 | 369 | 0 |
| ABEONA THERAPEUTICS INC | COM | 00289Y107 | 187 | 12,998 | SH | | DFND | 1 | 0 | 12,998 | 0 |
| ACCELERON PHARMA INC | COM | 00434H908 | 215 | 55 | SH | Call | DFND | 1 | 0 | 55 | 0 |
| ACCELERON PHARMA INC | COM | 00434H108 | 338 | 8,646 | SH | | DFND | 1 | 0 | 8,646 | 0 |
| ACCELERON PHARMA INC | COM | 00434H958 | 2,049 | 524 | SH | Put | DFND | 1 | 0 | 524 | 0 |
| ACHAOGEN INC | COM | 004449904 | 923 | 713 | SH | Call | DFND | 1 | 0 | 713 | 0 |
| ACHAOGEN INC | COM | 004449954 | 1,819 | 1,405 | SH | Put | DFND | 1 | 0 | 1,405 | 0 |
| ACTINIUM PHARMACEUTICALS INC | COM | 00507W107 | 729 | 1,997,700 | SH | | DFND | 1 | 0 | 1,997,700 | 0 |
| ADOMANI INC COM | COM | 00726A100 | 995 | 843,407 | SH | | DFND | 1 | 0 | 843,407 | 0 |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U908 | 548 | 944 | SH | Call | DFND | 1 | 0 | 944 | 0 |
| ADVERUM BIOTECHNOLOGIES INC | COM | 00773U108 | 1,154 | 198,964 | SH | | DFND | 1 | 0 | 198,964 | 0 |
| AFFIMED INC | COM | N01045108 | 787 | 425,463 | SH | | DFND | 1 | 0 | 425,463 | 0 |
| AKEBIA THERAPEUTICS INC | COM | 00972D105 | 975 | 102,338 | SH | | DFND | 1 | 0 | 102,338 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351959 | 1,070 | 96 | SH | Put | DFND | 1 | 0 | 96 | 0 |
| ALEXION PHARMACEUTICALS INC | COM | 015351909 | 6,610 | 593 | SH | Call | DFND | 1 | 0 | 593 | 0 |
| ALKERMES PLC | SHS | G01767955 | 910 | 157 | SH | Put | DFND | 1 | 0 | 157 | 0 |
| ALKERMES PLC | SHS | G01767905 | 3,918 | 676 | SH | Call | DFND | 1 | 0 | 676 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 1,370 | 11,500 | SH | | DFND | 1 | 0 | 11,500 | 0 |
| ALNYLAM PHARMACEUTICALS INC | COM | 02043Q957 | 2,978 | 250 | SH | Put | DFND | 1 | 0 | 250 | 0 |
| AMARIN CORP PLC | ADR | 023111206 | 61 | 20,300 | SH | | DFND | 1 | 0 | 20,300 | 0 |
| AMARIN CORP PLC | ADR | 023111956 | 334 | 1,109 | SH | Put | DFND | 1 | 0 | 1,109 | 0 |
| AMARIN CORP PLC | ADR | 023111906 | 2,504 | 8,319 | SH | Call | DFND | 1 | 0 | 8,319 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 976 | 64,910 | SH | | DFND | 1 | 0 | 64,910 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W959 | 1,504 | 1,000 | SH | Put | DFND | 1 | 0 | 1,000 | 0 |
| AMICUS THERAPEUTICS INC | COM | 03152W909 | 1,512 | 1,005 | SH | Call | DFND | 1 | 0 | 1,005 | 0 |
| AMPLIPHI BIOSCIENCES CORP | COM | 03211P301 | 907 | 831,961 | SH | | DFND | 1 | 0 | 831,961 | 0 |
| AMYRIS INC | COM | 03236M950 | 1,887 | 2,821 | SH | Put | DFND | 1 | 0 | 2,821 | 0 |
| APPLIED DNA SCIENCES INC | *W | 03815U110 | 162 | 648,824 | SH | | DFND | 1 | 0 | 648,824 | 0 |
| APPLIED DNA SCIENCES INC | COM | 03815U201 | 654 | 454,381 | SH | | DFND | 1 | 0 | 454,381 | 0 |
| APRICUS BIOSCIENCES INC | COM | 03832V307 | 731 | 1,800,000 | SH | | DFND | 1 | 0 | 1,800,000 | 0 |
| AQUABOUNTY TECHNOLOGIES INC | COM | 03842K200 | 0 | 113 | SH | | DFND | 1 | 0 | 113 | 0 |
| ARCADIA BIOSCIENCES INC | COM | 039014204 | 3,611 | 150,376 | SH | | DFND | 1 | 0 | 150,376 | 0 |
| ASTRAZENECA PLC | ADR | 046353958 | 29,305 | 8,380 | SH | Put | DFND | 1 | 0 | 8,380 | 0 |
| ASTRAZENECA PLC | ADR | 046353908 | 51,214 | 14,645 | SH | Call | DFND | 1 | 0 | 14,645 | 0 |
| AURIS MEDICAL HOLDING AG | COM | H0381L104 | 549 | 342,989 | SH | | DFND | 1 | 0 | 342,989 | 0 |
| AVEO PHARMACEUTICALS INC | COM | 053588909 | 2,486 | 8,571 | SH | Call | DFND | 1 | 0 | 8,571 | 0 |
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 199 | 81,159 | SH | | DFND | 1 | 0 | 81,159 | 0 |
| BENITEC BIOPHARMA LTD | *W | 082053117 | 21 | 87,693 | SH | Call | DFND | 1 | 0 | 87,693 | 0 |
| BIO PATH HOLDINGS INC | COM | 09057N102 | 170 | 85,013 | SH | | DFND | 1 | 0 | 85,013 | 0 |
| BIOAMBER INC | COM | 09072Q106 | 368 | 7,819,887 | SH | | DFND | 1 | 0 | 7,819,887 | 0 |
| BIOCEPT INC | COM | 09072V204 | 27 | 92,374 | SH | | DFND | 1 | 0 | 92,374 | 0 |
| BIOGEN INC | COM | 09062X903 | 821 | 30 | SH | Call | DFND | 1 | 0 | 30 | 0 |
| BIOGEN INC | COM | 09062X953 | 48,928 | 2,071 | SH | Put | DFND | 1 | 0 | 2,071 | 0 |
| BIOGEN INC | COM | 09062X103 | 50,081 | 182,898 | SH | | DFND | 1 | 0 | 182,898 | 0 |
| BRAINSTORM CELL THERAPEUTICS | COM | 10501E201 | 70 | 22,323 | SH | | DFND | 1 | 0 | 22,323 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122108 | 1,474 | 23,312 | SH | | DFND | 1 | 0 | 23,312 | 0 |
| BRISTOL MYERS SQUIBB | COM | 110122958 | 1,777 | 281 | SH | Put | DFND | 1 | 0 | 281 | 0 |
| CAN FITE BIOPHARMA LTD | ADR | 13471N102 | 1,768 | 1,228,091 | SH | | DFND | 1 | 0 | 1,228,091 | 0 |
| CELLECT BIOTECHNOLOGY LTD | ADS | 15116C102 | 1,557 | 243,980 | SH | | DFND | 1 | 0 | 243,980 | 0 |
| CELSION CORP | COM | 15117N503 | 828 | 369,860 | SH | | DFND | 1 | 0 | 369,860 | 0 |
| CHECK-CAP LTD | COM | M2361E112 | 39 | 75,280 | SH | | DFND | 1 | 0 | 75,280 | 0 |
| CHF SOLUTIONS INC | COM | 12542Q508 | 504 | 180,498 | SH | | DFND | 1 | 0 | 180,498 | 0 |
| CITIUS PHARMACEUTICALS INC | COM | 17322U207 | 1,988 | 641,201 | SH | | DFND | 1 | 0 | 641,201 | 0 |
| CYTORI THERAPEUTICS INC | COM | 23283K121 | 14 | 520,858 | SH | Call | DFND | 1 | 0 | 520,858 | 0 |
| DBV TECHNOLOGIES SA | ADS | 23306J901 | 595 | 258 | SH | Call | DFND | 1 | 0 | 258 | 0 |
| EDAP TMS SA | ADR | 268311107 | 141 | 60,600 | SH | | DFND | 1 | 0 | 60,600 | 0 |
| EDAP TMS SA | ADR | 268311957 | 234 | 1,008 | SH | Put | DFND | 1 | 0 | 1,008 | 0 |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 317 | 32,190 | SH | | DFND | 1 | 0 | 32,190 | 0 |
| ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 1,287 | 1,226,117 | SH | | DFND | 1 | 0 | 1,226,117 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W105 | 1,361 | 18,823 | SH | | DFND | 1 | 0 | 18,823 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W905 | 3,891 | 538 | SH | Call | DFND | 1 | 0 | 538 | 0 |
| ESPERION THERAPEUTICS INC | COM | 29664W955 | 43,781 | 6,053 | SH | Put | DFND | 1 | 0 | 6,053 | 0 |
| EYENOVIA INC | COM | 30234E104 | 908 | 97,770 | SH | | DFND | 1 | 0 | 97,770 | 0 |
| FIBROGEN INC | COM | 31572Q908 | 522 | 113 | SH | Call | DFND | 1 | 0 | 113 | 0 |
| FUELCELL ENERGY INC | COM | 35952H502 | 158 | 91,400 | SH | | DFND | 1 | 0 | 91,400 | 0 |
| FUELCELL ENERGY INC | COM | 35952H952 | 570 | 3,297 | SH | Put | DFND | 1 | 0 | 3,297 | 0 |
| GALECTIN THERAPEUTICS INC | COM | 363225952 | 100 | 210 | SH | Put | DFND | 1 | 0 | 210 | 0 |
| GALECTIN THERAPEUTICS INC | COM | 363225202 | 680 | 143,400 | SH | | DFND | 1 | 0 | 143,400 | 0 |
| GLOBAL BLOOD THERAPEUTICS INC | COM | 37890U908 | 3,661 | 758 | SH | Call | DFND | 1 | 0 | 758 | 0 |
| GLYCOMIMETICS INC | COM | 38000Q102 | 838 | 51,603 | SH | | DFND | 1 | 0 | 51,603 | 0 |
| HALOZYME THERAPEUTICS INC | COM | 40637H109 | 2 | 102 | SH | | DFND | 1 | 0 | 102 | 0 |
| HELIOS &MATHESON ANALYTICS INC | COM | 42327L950 | 581 | 2,054 | SH | Put | DFND | 1 | 0 | 2,054 | 0 |
| HELIOS &MATHESON ANALYTICS INC | COM | 42327L200 | 706 | 249,294 | SH | | DFND | 1 | 0 | 249,294 | 0 |
| IMMUNOCELLULAR THERAPEUTICS | *W | 452536121 | 7 | 225,187 | SH | Call | DFND | 1 | 0 | 225,187 | 0 |
| IMMUNOGEN INC | COM | 45253H951 | 173 | 164 | SH | Put | DFND | 1 | 0 | 164 | 0 |
| INCYTE CORP | COM | 45337C102 | 6,821 | 81,861 | SH | | DFND | 1 | 0 | 81,861 | 0 |
| INCYTE CORP | COM | 45337C902 | 9,500 | 1,140 | SH | Call | DFND | 1 | 0 | 1,140 | 0 |
| INCYTE CORP | COM | 45337C952 | 10,791 | 1,295 | SH | Put | DFND | 1 | 0 | 1,295 | 0 |
| INPIXON | COM | 45790J305 | 394 | 366,925 | SH | | DFND | 1 | 0 | 366,925 | 0 |
| INSMED INC | COM | 457669307 | 300 | 13,300 | SH | | DFND | 1 | 0 | 13,300 | 0 |
| INSMED INC | COM | 457669957 | 1,223 | 543 | SH | Put | DFND | 1 | 0 | 543 | 0 |
| INSPIREMD INC | *W | 45779A127 | 18 | 911,373 | SH | | DFND | 1 | 0 | 911,373 | 0 |
| INSPIREMD INC | *W | 45779A135 | 30 | 1,998,417 | SH | | DFND | 1 | 0 | 1,998,417 | 0 |
| INSPIREMD INC | COM | 45779A804 | 254 | 243,794 | SH | | DFND | 1 | 0 | 243,794 | 0 |
| INTERPACE DIAGNOSTICS GROUP | COM | 46062X204 | 812 | 919,854 | SH | | DFND | 1 | 0 | 919,854 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287905 | 37,958 | 2,500 | SH | Call | DFND | 1 | 0 | 2,500 | 0 |
| ISHARES RUSSELL 2000 | ETF | 464287955 | 43,651 | 2,875 | SH | Put | DFND | 1 | 0 | 2,875 | 0 |
| MANNKIND CORP | COM | 56400P706 | 228 | 1,000 | SH | Call | DFND | 1 | 0 | 1,000 | 0 |
| MANNKIND CORP | COM | 56400P706 | 460 | 201,908 | SH | | DFND | 1 | 0 | 201,908 | 0 |
| MANNKIND CORP | COM | 56400P906 | 735 | 3,224 | SH | Put | DFND | 1 | 0 | 3,224 | 0 |
| MARINUS PHARMACEUTICALS INC | COM | 56854Q901 | 172 | 451 | SH | Call | DFND | 1 | 0 | 451 | 0 |
| MEDIGUS LTD | ADR | 58471G201 | 30 | 23,606 | SH | | DFND | 1 | 0 | 23,606 | 0 |
| MERCK & CO INC | COM | 58933Y105 | 374 | 6,864 | SH | | DFND | 1 | 0 | 6,864 | 0 |
| MERCK & CO INC | COM | 58933Y955 | 654 | 120 | SH | Put | DFND | 1 | 0 | 120 | 0 |
| MERCK & CO INC | COM | 58933Y905 | 13,563 | 2,490 | SH | Call | DFND | 1 | 0 | 2,490 | 0 |
| MICROBOT MED INC | COM | 59503A105 | 843 | 1,249,400 | SH | | DFND | 1 | 0 | 1,249,400 | 0 |
| NANOVIBRONIX INC | COM | 63008J108 | 408 | 85,791 | SH | | DFND | 1 | 0 | 85,791 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268958 | 2,975 | 280 | SH | Put | DFND | 1 | 0 | 280 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268108 | 6,251 | 58,831 | SH | | DFND | 1 | 0 | 58,831 | 0 |
| NEKTAR THERAPEUTICS | COM | 640268908 | 7,704 | 725 | SH | Call | DFND | 1 | 0 | 725 | 0 |
| NEUROMETRIX INC | COM | 641255708 | 1,002 | 710,389 | SH | | DFND | 1 | 0 | 710,389 | 0 |
| NOVAN INC | COM | 66988N106 | 1,597 | 545,149 | SH | | DFND | 1 | 0 | 545,149 | 0 |
| ODONATE THERAPEUTICS INC | COM | 676079106 | 15,552 | 734,272 | SH | | DFND | 1 | 0 | 734,272 | 0 |
| ONCOBIOLOGICS INC | COM | 68235M105 | 1,876 | 2,108,249 | SH | | DFND | 1 | 0 | 2,108,249 | 0 |
| ONCONOVA THERAPEUTICS INC | *W | 68232V116 | 196 | 654,019 | SH | | DFND | 1 | 0 | 654,019 | 0 |
| ONCONOVA THERAPEUTICS INC | COM | 68232V306 | 334 | 399,580 | SH | | DFND | 1 | 0 | 399,580 | 0 |
| OPGEN INC | COM | 68373L109 | 875 | 521,076 | SH | | DFND | 1 | 0 | 521,076 | 0 |
| OVASCIENCE INC | COM | 69014Q101 | 1,185 | 1,461,525 | SH | | DFND | 1 | 0 | 1,461,525 | 0 |
| PAVMED INC | COM | 70387R106 | 1,490 | 908,817 | SH | | DFND | 1 | 0 | 908,817 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R952 | 17 | 122 | SH | Put | DFND | 1 | 0 | 122 | 0 |
| PLURISTEM THERAPEUTICS INC | COM | 72940R102 | 38 | 27,640 | SH | | DFND | 1 | 0 | 27,640 | 0 |
| PRECIPIO INC | COM | 74019L107 | 411 | 764,411 | SH | | DFND | 1 | 0 | 764,411 | 0 |
| PROQR THERAPEUTICS N V | SHS | N71542109 | 529 | 172,160 | SH | | DFND | 1 | 0 | 172,160 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800908 | 74 | 240 | SH | Call | DFND | 1 | 0 | 240 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800108 | 899 | 24,500 | SH | | DFND | 1 | 0 | 24,500 | 0 |
| PROTHENA CORPORATION PLC | SHS | G72800958 | 1,336 | 431 | SH | Put | DFND | 1 | 0 | 431 | 0 |
| PTC THERAPEUTICS INC | COM | 69366J900 | 84 | 1,475 | SH | Call | DFND | 1 | 0 | 1,475 | 0 |
| PULMATRIX INC | COM | 74584P103 | 554 | 1,087,507 | SH | | DFND | 1 | 0 | 1,087,507 | 0 |
| ROSETTA GENOMICS LTD | SHS | M82183209 | 383 | 934,608 | SH | | DFND | 1 | 0 | 934,608 | 0 |
| RXI PHARMACEUTICALS CORP | *W | 74979C121 | 88 | 196,522 | SH | | DFND | 1 | 0 | 196,522 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677906 | 435 | 229 | SH | Call | DFND | 1 | 0 | 229 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677106 | 2,701 | 142,136 | SH | | DFND | 1 | 0 | 142,136 | 0 |
| SANGAMO THERAPEUTICS INC | COM | 800677956 | 6,433 | 3,386 | SH | Put | DFND | 1 | 0 | 3,386 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607950 | 6,579 | 888 | SH | Put | DFND | 1 | 0 | 888 | 0 |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 17,285 | 2,333 | SH | Call | DFND | 1 | 0 | 2,333 | 0 |
| SELLAS LIFE SCIENCES GROUP INC | COM | 81642T900 | 4 | 1,518 | SH | Call | DFND | 1 | 0 | 1,518 | 0 |
| SELLAS LIFE SCIENCES GROUP INC | COM | 81642T100 | 1,067 | 309,207 | SH | | DFND | 1 | 0 | 309,207 | 0 |
| SENESTECH INC | COM | 81720R109 | 405 | 794,740 | SH | | DFND | 1 | 0 | 794,740 | 0 |
| SIGMA LABS INC | *W | 826598112 | 142 | 375,718 | SH | | DFND | 1 | 0 | 375,718 | 0 |
| SOLENO THERAPEUTICS | COM | 834203200 | 1,661 | 917,835 | SH | | DFND | 1 | 0 | 917,835 | 0 |
| SOLID BIOSCIENCES INC | COM | 83422E105 | 188 | 25,000 | SH | | DFND | 1 | 0 | 25,000 | 0 |
| SONOMA PHARMACEUTICALS INC | COM | 83558L105 | 255 | 69,200 | SH | | DFND | 1 | 0 | 69,200 | 0 |
| SOPHIRIS BIO INC | COM | 83578Q909 | 58 | 290 | SH | Call | DFND | 1 | 0 | 290 | 0 |
| SOPHIRIS BIO INC | COM | 83578Q959 | 147 | 729 | SH | Put | DFND | 1 | 0 | 729 | 0 |
| SPARK THERAPEUTICS INC | COM | 84652J903 | 5,161 | 775 | SH | Call | DFND | 1 | 0 | 775 | 0 |
| SPARK THERAPEUTICS INC | COM | 84652J953 | 6,759 | 1,015 | SH | Put | DFND | 1 | 0 | 1,015 | 0 |
| SPDR S&P 500 | TR | 78462F103 | 11,710 | 44,500 | SH | | DFND | 1 | 0 | 44,500 | 0 |
| SPDR S&P 500 | TR | 78462F953 | 259,650 | 9,867 | SH | Put | DFND | 1 | 0 | 9,867 | 0 |
| SPDR S&P BIOTECH | S&P BIOTECH | 78464A950 | 9,843 | 1,122 | SH | Put | DFND | 1 | 0 | 1,122 | 0 |
| STRATA SKIN SCIENCES INC | COM | 86272A206 | 368 | 315,745 | SH | | DFND | 1 | 0 | 315,745 | 0 |
| SUNESIS PHARMACEUTICALS INC | COM | 867328900 | 380 | 1,396 | SH | Call | DFND | 1 | 0 | 1,396 | 0 |
| SUPERCONDUCTOR TECHNOLOGIES | COM | 867931503 | 693 | 735,880 | SH | | DFND | 1 | 0 | 735,880 | 0 |
| SYNERGY PHARMACEUTICALS INC | COM | 871639908 | 907 | 4,954 | SH | Call | DFND | 1 | 0 | 4,954 | 0 |
| TRANSENTERIX INC | COM | 89366M951 | 124 | 728 | SH | Put | DFND | 1 | 0 | 728 | 0 |
| TRANSENTERIX INC | COM | 89366M201 | 436 | 256,715 | SH | | DFND | 1 | 0 | 256,715 | 0 |
| UNUM THERAPEUTICS INC | COM | 903214104 | 9,375 | 843,850 | SH | | DFND | 1 | 0 | 843,850 | 0 |
| VERSARTIS INC | COM | 92529L902 | 3 | 200 | SH | Call | DFND | 1 | 0 | 200 | 0 |
| VERSARTIS INC | COM | 92529L102 | 1,159 | 702,364 | SH | | DFND | 1 | 0 | 702,364 | 0 |
| VERTEX PHARMACEUTICALS INC | COM | 92532F900 | 861 | 1,315 | SH | Call | DFND | 1 | 0 | 1,315 | 0 |
| VICAL INC. | COM | 925602203 | 87 | 59,832 | SH | | DFND | 1 | 0 | 59,832 | 0 |
| VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 133 | 143,486 | SH | | DFND | 1 | 0 | 143,486 | 0 |
| VOLITIONRX LTD | COM | 928661107 | 32 | 13,167 | SH | | DFND | 1 | 0 | 13,167 | 0 |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 328 | 67,000 | SH | | DFND | 1 | 0 | 67,000 | 0 |
| ZOGENIX INC | COM | 98978L954 | 2,751 | 687 | SH | Put | DFND | 1 | 0 | 687 | 0 |
| ZOGENIX INC | COM | 98978L904 | 16,256 | 4,059 | SH | Call | DFND | 1 | 0 | 4,059 | 0 |
| ZOSANO PHARMA CORO | COM | 98979H202 | 1,178 | 233,779 | SH | | DFND | 1 | 0 | 233,779 | 0 |
