Yaron Tikotzky, Adv. (CPA)* Eli Doron, Adv. & Notary Ronen Kantor, Adv. Azriel Cederboum, Adv. Giora Gutman, Adv. Rachel (Goren) Cavallero, Adv. Gil Mor, Adv. & Notary** Sharon Fishman, Adv. & Notary Moti Hoffman, Adv. & Notary Efrat Hamami, Adv. Tamir Kalderon, Adv. Asaf Gershgoren, Adv .& economist Efi Ohana, Adv .& economist Ron Soulema, Adv. Sagiv Bar Shalom, Adv. Ori Perel, Adv. Asaf Hofman, Adv. & economist David Rozen, Adv. Israel Mark, Adv. Amir Bar-dayan, Adv. Sandrine Dray, Adv. & Notary*** Nahi Hamud, Adv. Shmulik Cohen, Adv. Yair Messalem, Adv. Maayan Peled, Adv. Igal Rosenberg, Adv. Lilach Cohen-Shamir, Adv. Rivka Mangoni, Adv. Gil Salomon, Adv. Israel Asaraf, Adv. Jossef Prins, Adv. Shay Almakies, Adv.& Notary Yael Porat Kotzer, Adv. Gali Ganoni, Adv. Odelia Cohen-Shondorf, Adv. Hasan Hasan, Adv. Yana Shapiro Orbach, Adv. Ronit Rabinovich, Adv. Nidal Siaga, Adv. Remon Zinaty, Adv. Avi Cohen, Adv. Amit Moshe Cohen, Adv. Sonny Knaz, Adv. Bat-El Ovadia, Adv. Aharon Eitan, Adv. Sivan Kaufman, Adv. Iris Borcom, Adv. Sivan Feldhamer, Adv. Inbal Naim, Adv. Roman Shalev, Adv. Amir Keren, Adv. Ariel Regev, Adv. Inbal Harel Gershon, Adv. Shirli Rahmani, Adv. Omer Katzir, Adv. Hadar Weizner, Adv. & economist Eli Kulas. Adv. Notary & Mediator- Counselor Jan Robinsohn, M.Jur. Adv. & Notary. Head of Polish desk - Counselor **** Giora Amir, Adv. Notary- Counselor *Member of the New York State Bar **Member of the Law Society in England & Wales | Can-Fite BioPharma Ltd. September 26, 2017 10 Bareket St. Petach Tikva 4951778 Israel Re: Form F-3 Registration Statement Ladies and Gentlemen: We have acted as Israeli counsel for Can-Fite BioPharma Ltd., an Israeli company organized under the laws of the State of Israel (the “Company”), in connection with the registration statement on Form F-3 (the “Registration Statement”) to be filed with the Securities and Exchange Commission (the “SEC”) on or about September 26, 2017 under the Securities Act of 1933, as amended (the “Act”). The Registration Statement relates to the proposed offer and sale by the Company from time to time, as set forth in the prospectus contained in the Registration Statement (the “Prospectus”) and as shall be set forth in one or more supplements to the Prospectus (each, a “Prospectus Supplement”), of up to a $50,000,000 aggregate amount of any of all the following securities (the “Securities”): (i) American Depositary Shares (“ADSs”) representing ordinary shares, no par value per share, of the Company (“Ordinary Shares”), (ii) Ordinary Shares, (iii) warrants to purchase ADSs and/or Ordinary Shares, including an expansion of the Company's existing warrants which are currently listed on The NASDAQ Capital Market (“Warrants”), (iv) subscription rights (“Subscription Rights”) to purchase ADSs and/or Ordinary Shares, and (v) units comprised of one or more of the securities that are offered under the Prospectus (“Units”). The Warrants will be issued under a warrant agreement (the “Warrant Agreement”) between the Company and a warrant agent (the “Warrant Agent”) and/or the Warrant holder. The Subscription Rights will be issued under a subscription rights agreement (the “Subscription Rights Agreement”) between the Company and a rights agent (the “Rights Agent”). The Units will be issued under a unit agreement (the “Unit Agreement”) between the Company and a unit agent (the “Unit Agent”). We also have assumed that: (1) at the time of execution, issuance and delivery of any Warrants, the related Warrant Agreement will be the valid and legally binding obligation of the Warrant Agent and/or the Warrant holder, as the case may be, enforceable against such party in accordance with its terms; (2) at the time of execution, issuance and delivery of any Subscription Rights, the related Subscription Rights Agreement will be the valid and legally binding obligation of the Rights Agent, enforceable against such party in accordance with its terms; (3) at the time of the execution, issuance and delivery of the Units, the related Unit Agreement will be the valid and legally binding obligation of the Unit Agent, enforceable against such party in accordance with its terms. We have assumed further that: (1) at the time of execution, issuance and delivery of any Warrants, the related Warrant Agreement will have been duly authorized, executed and delivered by the Company and the Warrant Agent and/or the Warrant holder, as the case may be; (2) at the time of execution, issuance and delivery of any Subscription Rights, the related Subscription Rights Agreement will have been duly authorized, executed and delivered by the Company and the Rights Agent; (3) at the time of execution, issuance and delivery of the Units, the Unit Agreement will have been duly authorized, executed and delivered by the Company and the Unit Agent; and (4) at the time of the issuance and sale of any of the Securities, the terms of the Securities, and their issuance and sale, will have been established so as not to violate any applicable law or regulation or result in a default under or breach of any agreement or instrument binding upon the Company and so as to comply with any requirement or restriction imposed by any court or governmental body having jurisdiction over the Company. |