UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
SCHEDULE 13D
(Amendment No. 6)*
Under the Securities Exchange Act of 1934
CLEARSIDE BIOMEDICAL, INC.
(Name of Issuer)
Common Stock, $0.001 Par Value
(Title of Class of Securities)
185063 10 4
(CUSIP Number)
Clay Thorp
280 S. Mangum Street, Suite 350
Durham, North Carolina 27701
(919) 484-0730
(Name, Address and Telephone Number of Person Authorized to Receive Notices and Communications)
December 15, 2022
(Date of Event which Requires Filing of this Statement)
If the filing person has previously filed a statement on Schedule l3G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of §§ 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. ☐
Note: Schedules filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See § 240.13d-7 for other parties to whom copies are to be sent.
| * | The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page. |
The information required on the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).
CUSIP No. 185063 10 4
Page 2 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-4822068
Hatteras Venture Advisors III, LLC | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
0 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
0 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
0 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 3 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-482290
Hatteras Venture Partners III, LP | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
0 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
0 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
0 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0% | |||||
| 14. | Type of Reporting Person
PN | |||||
CUSIP No. 185063 10 4
Page 4 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-5052088
Hatteras Venture Affiliates III, LP | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
0 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
0 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
0 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0% | |||||
| 14. | Type of Reporting Person
PN | |||||
CUSIP No. 185063 10 4
Page 5 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
Hatteras Venture Advisors IV SBIC, LLC | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
3,055,052 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
3,055,052 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
3,055,052 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☒ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.1% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 6 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 32-0389462
Hatteras Venture Partners IV SBIC, LP | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
3,055,052 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
3,055,052 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
3,055,052 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.1% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 7 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 20-4822068
Hatteras Venture Advisors IV, LLC | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
489,988 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
489,988 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
489,988 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☒ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0.8% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 8 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 45-2827886
Hatteras Venture Partners IV, LP | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
387,475 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
387,475 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
387,475 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0.6% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 9 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only) 38-3890444
Hatteras NC Fund, LP | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
0 | ||||
| 8. | Shared Voting Power
102,513 | |||||
| 9. | Sole Dispositive Power
0 | |||||
| 10. | Shared Dispositive Power
102,513 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
102,513 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
0.2% | |||||
| 14. | Type of Reporting Person
CO | |||||
CUSIP No. 185063 10 4
Page 10 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
John C. Crumpler | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
5,174 | ||||
| 8. | Shared Voting Power
3,545,040 | |||||
| 9. | Sole Dispositive Power
5,174 | |||||
| 10. | Shared Dispositive Power
3,545,040 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
$3,550,214 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.9% | |||||
| 14. | Type of Reporting Person
IN | |||||
CUSIP No. 185063 10 4
Page 11 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
Robert A. Ingram | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
10,262 | ||||
| 8. | Shared Voting Power
3,545,040 | |||||
| 9. | Sole Dispositive Power
10,262 | |||||
| 10. | Shared Dispositive Power
3,545,040 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
$3,555,302 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.9% | |||||
| 14. | Type of Reporting Person
IN | |||||
CUSIP No. 185063 10 4
Page 12 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
Kenneth B. Lee | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
5,174 | ||||
| 8. | Shared Voting Power
3,545,040 | |||||
| 9. | Sole Dispositive Power
5,174 | |||||
| 10. | Shared Dispositive Power
3,545,040 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
$3,550,214 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.9% | |||||
| 14. | Type of Reporting Person
IN | |||||
CUSIP No. 185063 10 4
Page 13 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
Clay B. Thorp | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
109,022 (1) | ||||
| 8. | Shared Voting Power
3,545,040 | |||||
| 9. | Sole Dispositive Power
109,022 (1) | |||||
| 10. | Shared Dispositive Power
3,545,040 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
3,654,062 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
6.1% | |||||
| 14. | Type of Reporting Person
IN | |||||
| 1 | Includes 16,522 shares held directly by the Reporting Person and 92,500 shares of Common Stock subject to options held by the Reporting Person that are exercisable within 60 days of December 20, 2022. |
CUSIP No. 185063 10 4
Page 14 of 20
| 1. | Name of Reporting Person I.R.S. Identification No. of Above Person (Entities Only)
Douglas Reed | |||||
| 2. | Check the Appropriate Box if a Member of a Group (a) ☐ (b) ☐
Not Applicable | |||||
| 3. | SEC Use Only
| |||||
| 4. | Source of Funds (See Instructions)
OO – See Item 3 | |||||
| 5. | Check if Disclosure of Legal Proceeding Is Required Pursuant to Items 2(d) or 2(e)
Not Applicable | |||||
| 6. | Citizenship or Place of Organization
United States | |||||
Number of Shares Beneficially Owned By Each Reporting Person with
| 7. | Sole Voting Power
6,392 | ||||
| 8. | Shared Voting Power
3,545,040 | |||||
| 9. | Sole Dispositive Power
6,392 | |||||
| 10. | Shared Dispositive Power
3,545,040 | |||||
| 11. | Aggregate Amount Beneficially Owned by Each Reporting Person
3,551,432 | |||||
| 12. | Check Box if the Aggregate Amount in Row (11) Excludes Certain Shares
☐ | |||||
| 13. | Percent of Class Represented by Amount in Row (11)
5.9% | |||||
| 14. | Type of Reporting Person
IN | |||||
CUSIP No. 185063 10 4
Page 15 of 20
This Amendment No. 6 on Schedule 13D amends the statement on Schedule 13D, dated June 7, 2016, which relates to the Common Stock, par value $0.001 per share (the “Common Stock”) of Clearside Biomedical, Inc. (the “Issuer”) which was previously amended on Schedule 13D/A, dated January 20 and April 17, 2017, March 21, 2018 and July 17 and December 4, 2019 filed by:
Hatteras Venture Advisors III, LLC (“HVA III”)
Hatteras Venture Partners III, LP (“HVP III”)
Hatteras Venture Affiliates III, LP (“HV Affiliates”)
Hatteras Venture Advisors IV SBIC, LLC (“HVA SBIC”)
Hatteras Venture Partners IV SBIC, LP (“HVP SBIC”)
Hatteras Venture Advisors IV, LLC (“HVA IV”)
Hatteras Venture Partners IV, LP (“HVP IV”)
Hatteras NC Fund, LP (“Hatteras Fund”)
John C. Crumpler
Robert A. Ingram
Kenneth B. Lee
Clay B. Thorp
Douglas Reed
(collectively, the “Reporting Persons”).
Except as expressly amended below, the Schedule 13D, dated June 7, 2016, remains in effect.
| Item 5. | Interest in Securities of the Issuer. |
| (a) | Aggregate number and percentage beneficially owned: |
HVA III — 0 or 0%
HVP III — 0 or 0%
HV Affiliates — 0 or 0%
HVA SBIC— 3,055,052 or 5.1%
HVP SBIC — 3,055,052 or 5.1%
HVA IV— 489,988 or less than 1%
HVP IV — 387,475 or less than 1%
Hatteras Fund— 102,513 or less than 1%
John C. Crumpler — 3,550,214 or 5.9%
Robert A. Ingram — 3,555,302 or 5.9%
Kenneth B. Lee — 3,550,214 or 5.9%
Clay B. Thorp — 3,654,062 or 6.1%
Douglas Reed — 3,551,432 or 5.9%
| (b) | Number of shares as to which the person has: |
| (i) | Sole power to vote or to direct the vote |
HVA III — 0
HVP III — 0
HV Affiliates — 0
HVA SBIC— 0
CUSIP No. 185063 10 4
Page 16 of 20
HVP SBIC — 0
HVA IV— 0
HVP IV — 0
Hatteras Fund— 0
John C. Crumpler — 5,174
Robert A. Ingram — 10,262
Kenneth B. Lee — 5,174
Clay B. Thorp — 109,022
Douglas Reed — 6,392
| (iii) | Sole power to dispose or to direct the disposition of |
HVA III — 0
HVP III — 0
HV Affiliates — 0
HVA SBIC— 0
HVP SBIC — 0
HVA IV— 0
HVP IV — 0
Hatteras Fund— 0
John C. Crumpler — 5,174
Robert A. Ingram — 10,262
Kenneth B. Lee — 5,174
Clay B. Thorp — 109,022
Douglas Reed — 6,392
| (iv) | Shared power to dispose or to direct the disposition of |
HVA III — 0
HVP III — 0
HV Affiliates — 0
HVA SBIC— 3,055,052
HVP SBIC — 3,055,052
HVA IV— 489,988
HVP IV — 387,475
Hatteras Fund— 102,513
John C. Crumpler — 3,545,040
Robert A. Ingram — 3,545,040
Kenneth B. Lee — 3,545,040
Clay B. Thorp — 3,545,040
Douglas Reed — 3,545,040
| (ii) | Shared power to vote or to direct the vote |
HVA III — 0
HVP III — 0
HV Affiliates — 0
HVA SBIC— 3,055,052
HVP SBIC — 3,055,052
HVA IV— 489,988
HVP IV — 387,475
Hatteras Fund— 102,513
John C. Crumpler — 3,545,040
CUSIP No. 185063 10 4
Page 17 of 20
Robert A. Ingram — 3,545,040
Kenneth B. Lee — 3,545,040
Clay B. Thorp — 3,545,040
Douglas Reed — 3,545,040
(c) Each of the required transactions described in this Item 5(a) were reported on Forms 4 filed by Mr. Thorp filed with the Securities and Exchange Commission (the “SEC”) pursuant to Section 16 of the Act and are available on the SEC’s website at www.sec.gov, except for the following:
[insert details related to the distributions-in-kind as the final details were not reported on Forms 4]
CUSIP No. 185063 10 4
Page 18 of 20
SIGNATURE
After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.
Date: January 4, 2023
| HATTERAS VENTURE ADVISORS III, LLC | ||
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS VENTURE PARTNERS III, LP | ||
| By: | Hatteras Venture Advisors III, LLC, its general partner | |
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS VENTURE AFFILIATES III, LP | ||
| By: | Hatteras Venture Advisors III, LLC, its general partner | |
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS VENTURE ADVISORS IV SBIC, LLC | ||
| By: | /s/ Clay B. Thorp | |
| Manager | ||
CUSIP No. 185063 10 4
Page 19 of 20
| HATTERAS VENTURE PARTNERS IV SBIC, LP | ||
| By: | Hatteras Venture Advisors IV SBIC, LLC, its general partner | |
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS VENTURE ADVISORS IV, LLC | ||
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS VENTURE PARTNERS IV, LP | ||
| By: | Hatteras Venture Advisors IV, LLC, its general partner | |
| By: | /s/ Clay B. Thorp | |
| Manager | ||
| HATTERAS NC FUND, LP | ||
| By: | Hatteras Venture Advisors IV, LLC, its general partner | |
| By: | /s/ Clay B. Thorp | |
| Manager | ||
* | ||
| John C. Crumpler | ||
* | ||
| Robert A. Ingram | ||
* | ||
| Kenneth B. Lee | ||
CUSIP No. 185063 10 4
Page 20 of 20
* | ||
| Clay B. Thorp | ||
* | ||
| Douglas Reed | ||
| By: | /s/ Clay B. Thorp | |
| Clay B. Thorp, as Attorney-in-Fact | ||
This Amendment No. 6 to Schedule 13D was executed by Clay B. Thorp on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which was previously filed with the Reporting Person’s Schedule 13D filed with the SEC on June 17, 2016 and as amended on February 8 and April 25, 2017, March 21, 2018 and July 17 and December 4, 2019.
