Clearside Biomedical (CLSD) 10-Q 10 May 18 2018 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2018	May 07, 2018
Document And Entity Information [Abstract]
Entity Registrant Name	Clearside Biomedical, Inc.
Amendment Flag	false
Document Period End Date	Mar. 31, 2018
Document Fiscal Year Focus	2,018
Document Fiscal Period Focus	Q1
Trading Symbol	CLSD
Document Type	10-Q
Entity Central Index Key	1,539,029
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		31,947,033

Balance Sheets

Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 84,834	$ 9,224
Short-term investments	16,221	28,416
Prepaid expenses	2,168	1,445
Other current assets	6	116
Total current assets	103,229	39,201
Property and equipment, net	838	885
Restricted cash	360	360
Other assets	35	47
Total assets	104,462	40,493
Current liabilities:
Accounts payable	6,744	5,384
Accrued liabilities	3,697	4,716
Current portion of long-term debt	3,200	3,200
Current portion of deferred rent	202	199
Other current liabilities		20
Total current liabilities	13,843	13,519
Long-term debt	4,107	4,809
Deferred rent	581	610
Deferred revenue		140
Total liabilities	18,531	19,078
Commitments and contingencies
Stockholders’ equity:
Preferred stock, $0.001 par value; 10,000,000 shares authorized and no shares issued at March 31, 2018 and December 31, 2017
Common stock, $0.001 par value; 100,000,000 shares authorized at March 31, 2018 and December 31, 2017; 31,947,033 and 25,354,651 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively	32	25
Additional paid-in capital	226,567	145,618
Accumulated deficit	(140,667)	(124,220)
Accumulated other comprehensive loss	(1)	(8)
Total stockholders’ equity	85,931	21,415
Total liabilities and stockholders’ equity	$ 104,462	$ 40,493

Balance Sheets (Parenthetical)

Balance Sheets (Parenthetical) - $ / shares	Mar. 31, 2018	Dec. 31, 2017
Statement Of Financial Position [Abstract]
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares, issued	31,947,033	25,354,651
Common stock, shares outstanding	31,947,033	25,354,651

Statements of Operations and Co

Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Income Statement [Abstract]
License revenue		$ 5
Operating expenses:
Research and development	$ 13,379	7,590
General and administrative	3,074	2,671
Total operating expenses	16,453	10,261
Loss from operations	(16,453)	(10,256)
Other expense, net	(154)	(117)
Net loss	$ (16,607)	$ (10,373)
Net loss per share of common stock — basic and diluted	$ (0.62)	$ (0.41)
Weighted average shares outstanding — basic and diluted	26,818,137	25,250,333
Net loss	$ (16,607)	$ (10,373)
Unrealized gain (loss) on available-for-sale investments	7	(8)
Comprehensive loss	$ (16,600)	$ (10,381)

Statements of Cash Flows

Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Operating activities
Net loss	$ (16,607)	$ (10,373)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	47	30
Share-based compensation expense	1,138	752
Non-cash interest expense	49	52
Accretion of debt discount	49	53
Amortization and accretion on available-for-sale investments, net	(43)	18
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	(613)	(2,305)
Other assets	12	(62)
Accounts payable and accrued liabilities	341	872
Deferred revenue		(5)
Deferred rent	(26)	(10)
Net cash used in operating activities	(15,653)	(10,978)
Investing activities
Purchase of available-for-sale investments	(8,725)	(12,656)
Maturities of available-for-sale investments	20,970	6,975
Acquisition of property and equipment		(309)
Net cash provided by (used in) investing activities	12,245	(5,990)
Financing activities
Proceeds from follow-on public offering, net of issuance costs	79,581	5,057
Proceeds from exercise of stock options	237	76
Principal payments made on long-term debt	(800)
Net cash provided by financing activities	79,018	5,133
Net increase (decrease) in cash, cash equivalents and restricted cash	75,610	(11,835)
Cash, cash equivalents and restricted cash, beginning of period	9,584	35,184
Cash, cash equivalents and restricted cash, end of period	$ 85,194	23,349
Supplemental schedule of noncash investing and financing activities
Tenant improvements paid by landlord		$ 637

The Company

The Company	3 Months Ended
	Mar. 31, 2018
Organization Consolidation And Presentation Of Financial Statements [Abstract]
The Company	1. The Company Clearside Biomedical, Inc. (the “Company”) is a late-stage clinical biopharmaceutical company developing first-in-class drug therapies to treat blinding diseases of the eye. The Company’s current product candidates are injected into the suprachoroidal space (“SCS”) using our proprietary SCS Microinjector, and focus on the treatment of diseases affecting the retina and choroid, especially diseases associated with macular edema. Incorporated in the State of Delaware on May 26, 2011, the Company has its corporate headquarters in Alpharetta, Georgia. The Company’s activities since inception have primarily consisted of developing product and technology rights, raising capital and performing research and development activities. The Company has no current source of revenue to sustain present activities, and does not expect to generate meaningful revenue until and unless the Company receives regulatory approval of, and successfully commercializes, its product candidates. The Company is subject to a number of risks and uncertainties similar to those of other life science companies at a similar stage of development, including, among others, the need to obtain adequate additional financing, successful development efforts, regulatory approval of products, compliance with government regulations, successful commercialization of potential products, protection of proprietary technology and dependence on key individuals. Liquidity The Company has funded its operations primarily through the proceeds of its public offerings of common stock, sale of convertible preferred stock and the issuance of long-term debt. On March 12, 2018, the Company closed a follow-on public offering in which it sold 6,538,462 shares of common stock at a public offering price of $13.00 per share, resulting in net proceeds of $79.6 million after deducting underwriting discounts and commissions and estimated offering expenses. The Company will continue to need to obtain additional financing to fund future operations, including completing the development and commercialization of its primary product candidates. The Company will need to expend substantial resources for research and development, including costs associated with the clinical testing of its product candidates. The Company will also need to obtain additional financing to conduct additional trials for the regulatory approval of its product candidates if requested by regulatory bodies, and to complete the development of any additional product candidates that might be acquired. If such products were to receive regulatory approval, the Company would need to prepare for the potential commercialization of its product candidates and fund the commercial launch of the products, if the Company decides to commercialize the products on its own. Moreover, the Company’s fixed expenses such as rent and other contractual commitments are substantial and are expected to increase in the future. The Company had cash, cash equivalents and short-term investments of $101.1 million as of March 31, 2018. In the absence of product or other revenues, the amount, timing, nature or source of which cannot be predicted, the Company’s losses will continue as it conducts its research and development activities. Until the Company can generate a sufficient amount of revenue, the Company may finance future cash needs through public or private equity offerings, license agreements, debt financings, collaborations, strategic alliances and marketing or distribution arrangements. The Company has incurred losses and negative cash flows since inception and expects operating losses and negative cash flows to continue into the foreseeable future. Absent raising additional funds, the Company expects that it will be able to delay, reduce or eliminate certain research and development programs or reduce administrative expense while still advancing clinical trials for key product candidates in order that the cash on hand as of the filing date, May 10, 2018, will be sufficient to fund its operations into the fourth quarter of 2019.

Significant Accounting Policies

Significant Accounting Policies	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
Significant Accounting Policies	2. Significant Accounting Policies Basis of Presentation The Company’s financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”). Unaudited Interim Financial Information The accompanying balance sheet as of March 31, 2018, statements of operations and comprehensive loss for the three months ended March 31, 2018 and 2017 and statements of cash flows for the three months ended March 31, 2018 and 2017 are unaudited. The unaudited interim financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include normal recurring adjustments, necessary for the fair presentation of the Company’s financial position as of March 31, 2018 and its results of its operations for the three months ended March 31, 2018 and 2017 and its cash flows for the three months ended March 31, 2018 and 2017. The financial data and other information disclosed in these notes related to the three months ended March 31, 2018 and 2017 are unaudited. The results for the three months ended March 31, 2018 are not indicative of results to be expected for the year ending December 31, 2018, any other interim periods or any future year or period. These unaudited financial statements should be read in conjunction with the audited financial statements and related footnotes, which are included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2017. Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of income and expenses during the reporting periods. Significant items subject to such estimates and assumptions include the accounting for useful lives to calculate depreciation and amortization, clinical trial estimates and related accrued liabilities, share-based compensation expense and income tax valuation allowance. Actual results could differ from these estimates. Research and Development Costs Research and development costs are charged to expense as incurred and include, but are not limited to: • employee-related expenses, including salaries, benefits, travel and share-based compensation expense for research and development personnel; • expenses incurred under agreements with contract research organizations, contract manufacturing organizations and consultants that conduct clinical trials and preclinical studies; • costs associated with nonclinical and clinical development activities; • costs associated with technology and intellectual property licenses; • costs for the Company’s research and development facility; and • depreciation expense for assets used in research and development activities. Costs for certain development activities, such as clinical trials, are recognized based on an evaluation of the progress to completion of specific tasks using data such as patient enrollment, clinical site activations, or information provided to the Company by its vendors on their actual costs incurred. Payments for these activities are based on the terms of the individual arrangements, which may differ from the patterns of costs incurred, and are reflected in the financial statements as prepaid or accrued expense. No material adjustments to these estimates have been recorded in these financial statements. Share-Based Compensation Compensation cost related to share-based awards granted to employees is measured based on the estimated fair value of the award at the grant date. The Company estimates the fair value of stock options using a Black-Scholes option pricing model. Compensation expense for options granted to non-employees is determined as the fair value of consideration received or the fair value of the equity instruments issued, whichever is more reliably measured. The fair value of awards granted to non-employees is re-measured each period until the related service is complete. Share-based compensation costs are expensed on a straight-line basis over the relevant vesting period. Compensation cost related to shares purchased through the Company’s employee stock purchase plan, which is considered compensatory, is based on the estimated fair value of the shares on the offering date, including consideration of the discount and the look back period. The Company estimates the fair value of the shares using a Black-Scholes option pricing model. Compensation expense is recognized over the six-month withholding period prior to the purchase date. All share-based compensation costs are recorded in general and administrative or research and development costs in the statements of operations and comprehensive loss based upon the underlying employees’ roles within the Company. Cash Equivalents Cash equivalents consist of short-term, highly liquid investments with an original term of three months or less at the date of purchase. Short-Term Investments Short-term investments are investments with original maturities of between 90 and 365 days when purchased and are comprised of commercial paper, corporate bonds and government bonds. The Company classifies its short-term investments as available-for-sale securities. Short-term investments are recorded at fair value and unrealized gains and losses are recorded within accumulated other comprehensive income (loss) until realized. In addition, the Company evaluates the short-investments with unrealized losses to determine whether such losses are other-than-temporary. Concentration of Credit Risk Arising From Cash Deposits in Excess of Insured Limits The Company maintains its cash in bank deposits that at times may exceed federally insured limits. The Company has not experienced any loss in such accounts. The Company believes it is not exposed to any significant risks with respect to its cash balances. Recent Accounting Pronouncements Accounting Pronouncements Recently Adopted In May 2014, the Financial Accounting Standards Board (“FASB”) Revenue from Contracts with Customers The Company adopted the standard effective January 1, 2018 using the modified retrospective transition method. After evaluating its current and prior license agreements, as well as its other collaboration agreements, the Company recorded the remaining $160,000 of deferred revenue as a cumulative adjustment to accumulated deficit. The adoption of the new standard did not have a material impact on the Company’s financial statements and related disclosures. In August 2016, the FASB Statement of Cash Flows Classification of Certain Cash Receipts and Cash Payments In November 2016, the FASB issued ASU 2016-18, Restricted Cash, The following table is a reconciliation of cash and cash equivalents and restricted cash reported within the balance sheets that sum to the total amounts in the statements of cash flows (in thousands). March 31, 2018 2017 Cash and cash equivalents $ 84,834 $ 22,989 Restricted cash 360 360 Cash, cash equivalents and restricted cash shown on the statements of cash flows $ 85,194 $ 23,349 Restricted cash consists of amounts held by a financial institution under a contractual agreement. In May 2017, the FASB issued ASU 2017-9 , Compensation-Stock Compensation: Scope of Stock Compensation Modification Accounting financial statements and related disclosure would depend on any future modifications to its share-based awards. Recent Accounting Pronouncements Not Yet Adopted In February 2016, the FASB issued ASU 2016-02, Leases (ASC 842),

Property and Equipment, Net

Property and Equipment, Net	3 Months Ended
	Mar. 31, 2018
Property Plant And Equipment [Abstract]
Property and Equipment, Net	3. Property and Equipment, Net Property and equipment, net consisted of the following (dollar amounts in thousands): Estimated Useful Lives (Years) March 31, 2018 December 2017 Furniture and fixtures 5 $ 303 $ 303 Machinery and equipment 5 121 121 Computer equipment 3 32 41 Leasehold improvements Lesser of useful life remaining lease term 667 667 1,123 1,132 Less: Accumulated depreciation (285 ) (247 ) $ 838 $ 885

Accrued Liabilities

Accrued Liabilities	3 Months Ended
	Mar. 31, 2018
Payables And Accruals [Abstract]
Accrued Liabilities	4. Accrued Liabilities Accrued liabilities consisted of the following (in thousands): March 31, December 2018 2017 Accrued research and development $ 2,682 $ 3,360 Accrued bonuses 274 920 Accrued professional fees 224 62 Accrued vacation 84 113 Accrued interest payable 54 58 Accrued expense 379 203 $ 3,697 $ 4,716

Long-Term Debt

Long-Term Debt	3 Months Ended
	Mar. 31, 2018
Debt Disclosure [Abstract]
Long-Term Debt	5. Long-Term Debt Loan and Security Agreements In September 2016, the Company entered into an amended and restated loan and security agreement, which was subsequently amended on October 31, 2017 (as amended, the “loan agreement”) with Silicon Valley Bank (“SVB”), MidCap Funding XII Trust and MidCap Financial Trust (together, “MidCap” and collectively with SVB, the “Lenders”), which amended and restated in its entirety the Company’s prior loan and security agreement. The loan agreement provides for new term loans of up to $15.0 million, with a floating interest rate equal to 7% plus the greater of (i) the 30-day U.S. LIBOR, as reported in the Wall Street Journal on the last business day of the month that immediately precedes the month in which the interest will accrue, or (ii) 0.50%. Under the terms of the loan agreement, an initial tranche of $8.0 million was advanced on September 28, 2016. The draw period for the remaining $7.0 million available under the loan agreement expired on March 31, 2018. The Company was required to pay accrued interest only on the outstanding $8.0 million balance through December 31, 2017, followed by 30 equal payments of principal and accrued interest. The Company has the option to prepay the outstanding balance of the term loans in full, subject to a prepayment fee of 2% of the original principal amount of the aggregate term loans for any prepayments through May 31, 2020. A final payment of $0.5 million, is due at maturity of the loan on June 1, 2020, or upon the prepayment of the facility or the acceleration of amounts due under the facility as a result of an event of default, and is being accreted in long-term debt over the life of the loan. Of the $8.0 million borrowed, $5.3 million was used to repay all amounts outstanding under the prior loan agreement. Closing costs incurred in the refinancing portion of the loan were recorded as expense while the financing costs for the new portion of the loan are recorded in long-term debt and being accreted over the life of the loan. Upon repayment of the original loan agreement, all remaining closing costs associated with the original loan agreement are being accreted to long-term debt over the life of the loan agreement. The term loans under the loan agreement are secured by substantially all of the Company’s assets, except that the collateral does not include any of the Company’s intellectual property. However, pursuant to the terms of a negative pledge arrangement, the Company has agreed not to encumber any of its intellectual property. Interest expense on the borrowings under the loan agreements was $161,000 and $156,000 for the three months ended March 31, 2018 and 2017, respectively. Accretion of the scheduled final payment was $49,000 and $52,000 for the three months ended March 31, 2018 and 2017, respectively. Accretion of the deferred debt issuance costs was $49,000 and $53,000 for the three months ended March 31, 2018 and 2017, respectively. As of March 31, 2018, the scheduled payments for the loan agreement, including the scheduled final payment in 2020, were as follows (in thousands): Year Ending December 31, Principal Interest and Final Total 2018 $ 2,400 $ 336 $ 2,736 2019 3,200 234 3,434 2020 1,600 545 2,145 $ 7,200 $ 1,115 $ 8,315

Common Stock

Common Stock	3 Months Ended
	Mar. 31, 2018
Equity [Abstract]
Common Stock	6. Common Stock The Company’s amended and restated certificate of incorporation authorizes the Company to issue 100,000,000 shares of $0.001 par value common stock. As of March 31, 2018 and December 31, 2017, there were 31,947,033 and 25,354,651 shares of common stock outstanding, respectively.

Stock Purchase Warrants

Stock Purchase Warrants	3 Months Ended
	Mar. 31, 2018
Stock Purchase Warrants [Abstract]
Stock Purchase Warrants	7. Stock Purchase Warrants In September 2016, in connection with the loan agreement (see Note 5), the Company issued warrants to the Lenders to purchase up to 29,796 shares of common stock at a price per share of $10.74. The warrants expire in September 2026, or earlier upon the occurrence of specified mergers or acquisitions of the Company, and are immediately exercisable .

Share-Based Compensation

Share-Based Compensation	3 Months Ended
	Mar. 31, 2018
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Share-Based Compensation	8. Share-Based Compensation Share-based compensation is accounted for in accordance with the provisions of ASC 718, Compensation-Stock Compensation Stock Options The Company has granted stock option awards to employees, directors and consultants from its 2011 Stock Incentive Plan (the “2011 Plan”) and its 2016 Equity Incentive Plan (the “2016 Plan”). The estimated fair value of options granted is determined as of the date of grant using the Black-Scholes option pricing model. The resulting fair value is recognized ratably over the requisite service period, which is generally the vesting period of the awards. Options granted to non-employees are re-measured at each financial reporting period until required services are performed. Share-based compensation expense for options granted under the 2011 Plan and the 2016 Plan is reflected in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended March 31, 2018 2017 Research and development $ 431 $ 325 General and administrative 702 417 Total $ 1,133 $ 742 The following table summarizes the activity related to stock options during the three months ended March 31, 2018: Weighted Number of Average Shares Exercise Price Options outstanding at January 1, 2018 3,075,349 $ 6.17 Granted 142,500 6.23 Exercised (53,920 ) 4.40 Forfeited (28,000 ) 7.72 Options outstanding at March 31, 2018 3,135,929 6.19 Options exercisable at December 31, 2017 1,114,286 3.94 Options exercisable at March 31, 2018 1,170,429 4.28 As of March 31, 2018, the Company had $11.0 million of unrecognized compensation expense related to unvested stock options, which is expected to be recognized over a weighted average period of 2.9 years. Employee Stock Purchase Plan In January 2016, the Company’s board of directors adopted and approved, and in January 2016 the Company’s stockholders approved, the Clearside Biomedical, Inc. 2016 Employee Stock Purchase Plan (the “2016 ESPP”) which became effective on June 1, 2016. The first offering period for the 2016 ESPP commenced January 1, 2017. The 2016 ESPP is considered a compensatory plan and the fair value of the discount and the look-back period are estimated using the Black-Scholes option pricing model and expense is recognized over the six month withholding period prior to the purchase date. The Company has issued a total of 9,692 shares of common stock purchased under the 2016 ESPP. For the three months ended March 31, 2018 and 2017, the Company has reported $5,000 and $10,000, respectively, of share-based compensation expense in the statements of operations and comprehensive loss for the estimated number of shares to be purchased on the next purchase date.

Commitment and Contingencies

Commitment and Contingencies	3 Months Ended
	Mar. 31, 2018
Commitments And Contingencies Disclosure [Abstract]
Commitments and Contingencies	9. Commitments and Contingencies Lease Commitment Summary In November 2016, the Company signed an office lease agreement to lease approximately 20,000 square feet of office space in Alpharetta, Georgia for its corporate headquarters. The lease agreement is for a 6.5 year term with a renewal option for one additional five-year term. Rental payments are $35,145 per month subject to an increase of 3% per year. Rent expense under this lease is recognized on a straight-line basis over the term of the lease. In addition, the lease agreement requires payment of the pro-rata share of the annual operating expenses associated with the premises. The Company relocated to this new space in March 2017. Total future minimum lease payments were as follows at March 31, 2018 (in thousands): Year Ending December 31, 2018 $ 326 2019 444 2020 458 2021 472 Thereafter 860 Total minimum lease payments $ 2,560 Rent expense was $58,000 and $40,000 for three months ended March 31, 2018 and 2017, respectively. Contract Service Providers In the course of the Company’s normal business operations, it has agreements with contract service providers to assist in the performance of its research and development, clinical research and manufacturing. Substantially all of these contracts are on an as needed basis.

License and Collaboration Agree

License and Collaboration Agreements	3 Months Ended
	Mar. 31, 2018
License And Collaboration Agreements [Abstract]
License and Collaboration Agreements	10. License and Collaboration Agreements In August 2014, the Company entered into a royalty-bearing license agreement with NovaMedica LLC (“NovaMedica”). Under this agreement, the Company granted to NovaMedica the right to use the Company’s intellectual property to develop and commercialize the intended products (the “Covered Products”) and to have the exclusive right to sell those products in Russia and specified adjacent territories involving the use of the corticosteroid triamcinolone acetonide as the sole active pharmaceutical ingredient for administration in the SCS. In connection with this royalty-bearing license, NovaMedica made an upfront payment to the Company of $200,000. The Company is currently developing product candidates that, when completed, would be subject to this license giving NovaMedica the exclusive right to then sell the products in the specified geographic territories. In mid-December 2015, the Company received positive results from the Phase 2 clinical trial relating to the product candidate and determined, based on these results, that the intellectual property could become commercially feasible. Beginning in the first quarter of 2016, the Company began recognizing the $200,000 to revenue over the period of time estimated to complete clinical development and commercialization of the Covered Products and the beginning of the first set of patent expirations in 2027. On January 1, 2018, upon the adoption of ASU 2014-09, the Company accelerated the recognition of the deferred revenue and recorded the remaining balance of $160,000 as a cumulative adjustment to accumulated deficit. The Company recorded $5,000 of license revenue during the three months ended March 31, 2017, from this license agreement. NovaMedica is jointly owned by Rusnano MedInvest LLC and Domain Russia Investments Limited. The Company has periodically entered into other short-term collaboration agreements, generally with performance obligations of one-to-two months, to evaluate the potential use of its proprietary SCS Microinjector with third-party product candidates for the treatment of various diseases. Funds received from these collaboration agreements are recognized as revenue over the term of the agreement.

Available-for-Sale Investments

Available-for-Sale Investments	3 Months Ended
	Mar. 31, 2018
Investments Debt And Equity Securities [Abstract]
Available-for-Sale Investments	11. Available-for-Sale Investments The following table summarizes the Company’s available-for-sale investments (in thousands): March 31, 2018 Amortized Unrealized Fair Cost Losses Value Government bonds $ 1,000 $ — $ 1,000 Commercial paper 14,472 — 14,472 Corporate bonds 750 (1 ) 749 Total available-for-sale investments $ 16,222 $ (1 ) $ 16,221

Fair Value Measurements

Fair Value Measurements	3 Months Ended
	Mar. 31, 2018
Fair Value Disclosures [Abstract]
Fair Value Measurements	12. Fair Value Measurements The Company records certain financial assets and liabilities at fair value in accordance with the provisions of ASC Topic 820, Fair Value Measurements and Disclosures • Level 1—Unadjusted quoted prices in active, accessible markets for identical assets or liabilities. • Level 2—Other inputs that are directly or indirectly observable in the marketplace. • Level 3—Unobservable inputs that are supported by little or no market activity. The fair value hierarchy also requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The Company’s material financial instruments at March 31, 2018 and December 31, 2017 consisted primarily of cash and cash equivalents, short-term investments and long-term debt. The fair value of cash and cash equivalents, government bonds, other current assets and accounts payable approximate their respective carrying values due to the short term nature of these instruments and are classified as Level 1 in the fair hierarchy. The fair value of long-term debt approximates the carrying value due to variable interest rates that correspond to market rates. The Company has determined its short-term investments, comprised of corporate bonds and commercial paper, to be Level 2 in the fair value hierarchy. The fair value was determined using a market approach, based on prices and other relevant information generated by market transactions involving similar assets. The short-term investments consist of investments with original maturity dates from date of acquisition of 90 to 365 days and are classified as available-for-sale. There were no significant transfers between Levels 1, 2 and 3 during the three months ended March 31, 2018 and the year ended December 31, 2017. The following tables summarize the fair value of financial assets that are measured at fair value and the classification by level of input within the fair value hierarchy (in thousands): March 31, 2018 Level 1 Level 2 Level 3 Recorded Value Financial Assets: Cash and money markets $ 66,530 $ — $ — $ 66,530 Restricted cash money market 360 — — 360 Government bonds 1,000 — — 1,000 Corporate bonds — 749 — 749 Commercial paper — 32,776 — 32,776 Total financial assets $ 67,890 $ 33,525 $ — $ 101,415 December 31, 2017 Level 1 Level 2 Level 3 Recorded Value Financial Assets: Cash and money markets $ 9,224 $ — $ — $ 9,224 Restricted cash money market 360 — — 360 Government bonds 11,238 — — 11,238 Certificates of deposit — 1,960 — 1,960 Corporate bonds — 5,064 — 5,064 Commercial paper — 10,154 — 10,154 Total financial assets $ 20,822 $ 17,178 $ — $ 38,000

Net Loss per Share

Net Loss per Share	3 Months Ended
	Mar. 31, 2018
Earnings Per Share [Abstract]
Net Loss Per Share	13. Net Loss Per Share Basic net loss per share is calculated by dividing the net loss by the weighted average number of shares of common stock outstanding for the period, without consideration of the dilutive effect of potential common stock equivalents. Diluted net loss per share gives effect to all dilutive potential shares of common stock outstanding during this period. For all periods presented, the Company’s potential common stock equivalents, which included stock options and stock purchase warrants, have been excluded from the computation of diluted net loss per share as their inclusion would have the effect of reducing the net loss per share. Therefore, the denominator used to calculate both basic and diluted net loss per share is the same in all periods presented. The Company’s potential common stock equivalents that have been excluded from the computation of diluted net loss per share for all periods presented because of their antidilutive effect consisted of the following: Three Months Ended March 31, 2018 2017 Outstanding stock options 3,135,929 2,179,092 Stock purchase warrants 29,796 29,796 3,165,725 2,208,888

Subsequent Event

Subsequent Event	3 Months Ended
	Mar. 31, 2018
Subsequent Events [Abstract]
Subsequent Event	14 . Subsequent Event On May 8, 2018, the Company entered into a Supply Agreement with Gerresheimer Regensburg GMBH, a company incorporated under laws of Germany (“Gerresheimer”), pursuant to which Gerresheimer will manufacture and supply the Company’s proprietary SCS Microinjector in accordance with purchase orders from the Company. The agreement contains an initial five-year term that will automatically renew for successive periods of three years.

Significant Accounting Polici20

Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The Company’s financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“U.S. GAAP”).
Unaudited Interim Financial Information	Unaudited Interim Financial Information The accompanying balance sheet as of March 31, 2018, statements of operations and comprehensive loss for the three months ended March 31, 2018 and 2017 and statements of cash flows for the three months ended March 31, 2018 and 2017 are unaudited. The unaudited interim financial statements have been prepared on the same basis as the annual financial statements and, in the opinion of management, reflect all adjustments, which include normal recurring adjustments, necessary for the fair presentation of the Company’s financial position as of March 31, 2018 and its results of its operations for the three months ended March 31, 2018 and 2017 and its cash flows for the three months ended March 31, 2018 and 2017. The financial data and other information disclosed in these notes related to the three months ended March 31, 2018 and 2017 are unaudited. The results for the three months ended March 31, 2018 are not indicative of results to be expected for the year ending December 31, 2018, any other interim periods or any future year or period. These unaudited financial statements should be read in conjunction with the audited financial statements and related footnotes, which are included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2017.
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of income and expenses during the reporting periods. Significant items subject to such estimates and assumptions include the accounting for useful lives to calculate depreciation and amortization, clinical trial estimates and related accrued liabilities, share-based compensation expense and income tax valuation allowance. Actual results could differ from these estimates.
Research and Development Costs	Research and Development Costs Research and development costs are charged to expense as incurred and include, but are not limited to: • employee-related expenses, including salaries, benefits, travel and share-based compensation expense for research and development personnel; • expenses incurred under agreements with contract research organizations, contract manufacturing organizations and consultants that conduct clinical trials and preclinical studies; • costs associated with nonclinical and clinical development activities; • costs associated with technology and intellectual property licenses; • costs for the Company’s research and development facility; and • depreciation expense for assets used in research and development activities. Costs for certain development activities, such as clinical trials, are recognized based on an evaluation of the progress to completion of specific tasks using data such as patient enrollment, clinical site activations, or information provided to the Company by its vendors on their actual costs incurred. Payments for these activities are based on the terms of the individual arrangements, which may differ from the patterns of costs incurred, and are reflected in the financial statements as prepaid or accrued expense. No material adjustments to these estimates have been recorded in these financial statements.
Share-Based Compensation	Share-Based Compensation Compensation cost related to share-based awards granted to employees is measured based on the estimated fair value of the award at the grant date. The Company estimates the fair value of stock options using a Black-Scholes option pricing model. Compensation expense for options granted to non-employees is determined as the fair value of consideration received or the fair value of the equity instruments issued, whichever is more reliably measured. The fair value of awards granted to non-employees is re-measured each period until the related service is complete. Share-based compensation costs are expensed on a straight-line basis over the relevant vesting period. Compensation cost related to shares purchased through the Company’s employee stock purchase plan, which is considered compensatory, is based on the estimated fair value of the shares on the offering date, including consideration of the discount and the look back period. The Company estimates the fair value of the shares using a Black-Scholes option pricing model. Compensation expense is recognized over the six-month withholding period prior to the purchase date. All share-based compensation costs are recorded in general and administrative or research and development costs in the statements of operations and comprehensive loss based upon the underlying employees’ roles within the Company.
Cash Equivalents	Cash Equivalents Cash equivalents consist of short-term, highly liquid investments with an original term of three months or less at the date of purchase.
Short-Term Investments	Short-Term Investments Short-term investments are investments with original maturities of between 90 and 365 days when purchased and are comprised of commercial paper, corporate bonds and government bonds. The Company classifies its short-term investments as available-for-sale securities. Short-term investments are recorded at fair value and unrealized gains and losses are recorded within accumulated other comprehensive income (loss) until realized. In addition, the Company evaluates the short-investments with unrealized losses to determine whether such losses are other-than-temporary.
Concentration of Credit Risk Arising From Cash Deposits in Excess of Insured Limits	Concentration of Credit Risk Arising From Cash Deposits in Excess of Insured Limits The Company maintains its cash in bank deposits that at times may exceed federally insured limits. The Company has not experienced any loss in such accounts. The Company believes it is not exposed to any significant risks with respect to its cash balances.
Recent Accounting Pronouncements	Recent Accounting Pronouncements Accounting Pronouncements Recently Adopted In May 2014, the Financial Accounting Standards Board (“FASB”) Revenue from Contracts with Customers The Company adopted the standard effective January 1, 2018 using the modified retrospective transition method. After evaluating its current and prior license agreements, as well as its other collaboration agreements, the Company recorded the remaining $160,000 of deferred revenue as a cumulative adjustment to accumulated deficit. The adoption of the new standard did not have a material impact on the Company’s financial statements and related disclosures. In August 2016, the FASB Statement of Cash Flows Classification of Certain Cash Receipts and Cash Payments In November 2016, the FASB issued ASU 2016-18, Restricted Cash, The following table is a reconciliation of cash and cash equivalents and restricted cash reported within the balance sheets that sum to the total amounts in the statements of cash flows (in thousands). March 31, 2018 2017 Cash and cash equivalents $ 84,834 $ 22,989 Restricted cash 360 360 Cash, cash equivalents and restricted cash shown on the statements of cash flows $ 85,194 $ 23,349 Restricted cash consists of amounts held by a financial institution under a contractual agreement. In May 2017, the FASB issued ASU 2017-9 , Compensation-Stock Compensation: Scope of Stock Compensation Modification Accounting financial statements and related disclosure would depend on any future modifications to its share-based awards. Recent Accounting Pronouncements Not Yet Adopted In February 2016, the FASB issued ASU 2016-02, Leases (ASC 842),

Significant Accounting Polici21

Significant Accounting Policies (Tables)	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
Schedule of Reconciliation of Cash and Cash Equivalents and Restricted Cash	The following table is a reconciliation of cash and cash equivalents and restricted cash reported within the balance sheets that sum to the total amounts in the statements of cash flows (in thousands). March 31, 2018 2017 Cash and cash equivalents $ 84,834 $ 22,989 Restricted cash 360 360 Cash, cash equivalents and restricted cash shown on the statements of cash flows $ 85,194 $ 23,349

Property and Equipment, Net (Ta

Property and Equipment, Net (Tables)	3 Months Ended
	Mar. 31, 2018
Property Plant And Equipment [Abstract]
Schedule of Property and Equipment, Net	Property and equipment, net consisted of the following (dollar amounts in thousands): Estimated Useful Lives (Years) March 31, 2018 December 2017 Furniture and fixtures 5 $ 303 $ 303 Machinery and equipment 5 121 121 Computer equipment 3 32 41 Leasehold improvements Lesser of useful life remaining lease term 667 667 1,123 1,132 Less: Accumulated depreciation (285 ) (247 ) $ 838 $ 885

Accrued Liabilities (Tables)

Accrued Liabilities (Tables)	3 Months Ended
	Mar. 31, 2018
Payables And Accruals [Abstract]
Schedule of Accrued Liabilities	Accrued liabilities consisted of the following (in thousands): March 31, December 2018 2017 Accrued research and development $ 2,682 $ 3,360 Accrued bonuses 274 920 Accrued professional fees 224 62 Accrued vacation 84 113 Accrued interest payable 54 58 Accrued expense 379 203 $ 3,697 $ 4,716

Long-Term Debt (Tables)

Long-Term Debt (Tables)	3 Months Ended
	Mar. 31, 2018
Debt Disclosure [Abstract]
Scheduled Payments for the Loan Agreement	As of March 31, 2018, the scheduled payments for the loan agreement, including the scheduled final payment in 2020, were as follows (in thousands): Year Ending December 31, Principal Interest and Final Total 2018 $ 2,400 $ 336 $ 2,736 2019 3,200 234 3,434 2020 1,600 545 2,145 $ 7,200 $ 1,115 $ 8,315

Share-Based Compensation (Table

Share-Based Compensation (Tables)	3 Months Ended
	Mar. 31, 2018
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]
Summary of Share-based Compensation Expense	Share-based compensation expense for options granted under the 2011 Plan and the 2016 Plan is reflected in the statements of operations and comprehensive loss as follows (in thousands): Three Months Ended March 31, 2018 2017 Research and development $ 431 $ 325 General and administrative 702 417 Total $ 1,133 $ 742
Summary of Activity Related to Stock Options	The following table summarizes the activity related to stock options during the three months ended March 31, 2018: Weighted Number of Average Shares Exercise Price Options outstanding at January 1, 2018 3,075,349 $ 6.17 Granted 142,500 6.23 Exercised (53,920 ) 4.40 Forfeited (28,000 ) 7.72 Options outstanding at March 31, 2018 3,135,929 6.19 Options exercisable at December 31, 2017 1,114,286 3.94 Options exercisable at March 31, 2018 1,170,429 4.28

Commitment and Contingencies (T

Commitment and Contingencies (Tables)	3 Months Ended
	Mar. 31, 2018
Commitments And Contingencies Disclosure [Abstract]
Total Future Minimum Commitments Due Under Non-Cancelable Operating Leases	Total future minimum lease payments were as follows at March 31, 2018 (in thousands): Year Ending December 31, 2018 $ 326 2019 444 2020 458 2021 472 Thereafter 860 Total minimum lease payments $ 2,560

Available-for-Sale Investments

Available-for-Sale Investments (Tables)	3 Months Ended
	Mar. 31, 2018
Investments Debt And Equity Securities [Abstract]
Summary of Company's Available-For-Sale Investments	The following table summarizes the Company’s available-for-sale investments (in thousands): March 31, 2018 Amortized Unrealized Fair Cost Losses Value Government bonds $ 1,000 $ — $ 1,000 Commercial paper 14,472 — 14,472 Corporate bonds 750 (1 ) 749 Total available-for-sale investments $ 16,222 $ (1 ) $ 16,221

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
	Mar. 31, 2018
Fair Value Disclosures [Abstract]
Summary of Assets Measured at Fair Value	The following tables summarize the fair value of financial assets that are measured at fair value and the classification by level of input within the fair value hierarchy (in thousands): March 31, 2018 Level 1 Level 2 Level 3 Recorded Value Financial Assets: Cash and money markets $ 66,530 $ — $ — $ 66,530 Restricted cash money market 360 — — 360 Government bonds 1,000 — — 1,000 Corporate bonds — 749 — 749 Commercial paper — 32,776 — 32,776 Total financial assets $ 67,890 $ 33,525 $ — $ 101,415 December 31, 2017 Level 1 Level 2 Level 3 Recorded Value Financial Assets: Cash and money markets $ 9,224 $ — $ — $ 9,224 Restricted cash money market 360 — — 360 Government bonds 11,238 — — 11,238 Certificates of deposit — 1,960 — 1,960 Corporate bonds — 5,064 — 5,064 Commercial paper — 10,154 — 10,154 Total financial assets $ 20,822 $ 17,178 $ — $ 38,000

Net Loss per Share (Tables)

Net Loss per Share (Tables)	3 Months Ended
	Mar. 31, 2018
Earnings Per Share [Abstract]
Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share	The Company’s potential common stock equivalents that have been excluded from the computation of diluted net loss per share for all periods presented because of their antidilutive effect consisted of the following: Three Months Ended March 31, 2018 2017 Outstanding stock options 3,135,929 2,179,092 Stock purchase warrants 29,796 29,796 3,165,725 2,208,888

The Company - Additional Inform

The Company - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	Mar. 12, 2018	Mar. 31, 2018	Mar. 31, 2017
Organization Consolidation And Presentation Of Financial Statements [Abstract]
Entity incorporation date		May 26, 2011
Issuance of common stock for follow-on public offering, shares	6,538,462
Common stock, Share offering price	$ 13
Net offering proceeds after deducting underwriting discount and commissions and estimated offering expenses	$ 79,600	$ 79,581	$ 5,057
Cash, cash equivalents and short-term investments		$ 101,100

Significant Accounting Polici31

Significant Accounting Policies - Additional Information (Details) - USD ($)	Jan. 01, 2018	Mar. 31, 2018
Significant Accounting Policies [Line Items]
Short-term investments maturity start period		90 days
Short-term investments maturity end period		365 days
ASU 2014-09
Significant Accounting Policies [Line Items]
Cumulative adjustment to accumulated deficit	$ 160,000

Significant Accounting Polici32

Significant Accounting Policies - Schedule on Reconciliation of Cash and Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017	Dec. 31, 2016
Cash And Cash Equivalents [Abstract]
Cash and cash equivalents	$ 84,834	$ 9,224	$ 22,989
Restricted cash	360	360	360
Cash, cash equivalents and restricted cash shown on the statements of cash flows	$ 85,194	$ 9,584	$ 23,349	$ 35,184

Property and Equipment, Net - S

Property and Equipment, Net - Schedule of Property and Equipment, Net (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Property Plant And Equipment [Line Items]
Property and Equipment, gross	$ 1,123	$ 1,132
Less: Accumulated depreciation	(285)	(247)
Property and equipment, net	838	885
Furniture and Fixtures
Property Plant And Equipment [Line Items]
Property and Equipment, gross	$ 303	303
Estimated Useful Lives (Years)	5 years
Machinery and Equipment
Property Plant And Equipment [Line Items]
Property and Equipment, gross	$ 121	121
Estimated Useful Lives (Years)	5 years
Computer Equipment
Property Plant And Equipment [Line Items]
Property and Equipment, gross	$ 32	41
Estimated Useful Lives (Years)	3 years
Leasehold Improvements
Property Plant And Equipment [Line Items]
Property and Equipment, gross	$ 667	$ 667
Estimated Useful Lives (Years)	Lesser of useful life or remaining lease term

Accrued Liabilities - Schedule

Accrued Liabilities - Schedule of Accrued Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Payables And Accruals [Abstract]
Accrued research and development	$ 2,682	$ 3,360
Accrued bonuses	274	920
Accrued professional fees	224	62
Accrued vacation	84	113
Accrued interest payable	54	58
Accrued expense	379	203
Accrued liabilities, current	$ 3,697	$ 4,716

Long-Term Debt - Additional Inf

Long-Term Debt - Additional Information (Details) - USD ($)	Sep. 28, 2016	Sep. 30, 2016	Mar. 31, 2018	Mar. 31, 2017
Debt Instrument [Line Items]
Long term debt			$ 7,200,000
Interest expense on borrowings			161,000	$ 156,000
Accretion of scheduled final payment			49,000	52,000
Accretion of deferred debt issuance costs			49,000	$ 53,000
Silicon Valley Bank , MidCap Funding XII Trust and MidCap Financial Trust
Debt Instrument [Line Items]
Long term debt	$ 8,000,000
Line of credit facility, remaining borrowing capacity			$ 7,000,000
Debt Instrument, Payment Terms			The Company was required to pay accrued interest only on the outstanding $8.0 million balance through December 31, 2017, followed by 30 equal payments of principal and accrued interest.
Final payment during maturity			$ 500,000
Debt instrument, maturity date			Jun. 1, 2020
Repay all the amount outstanding under the prior loan agreement	$ 5,300,000
Silicon Valley Bank , MidCap Funding XII Trust and MidCap Financial Trust | Prepayments Through May 31, 2020
Debt Instrument [Line Items]
Prepayment fee percentage of the original principal amount of the aggregate term loans		2.00%
Silicon Valley Bank , MidCap Funding XII Trust and MidCap Financial Trust | Amended and Restated Loan and Security Agreement
Debt Instrument [Line Items]
Interest rate		0.50%
Debt instrument, description of variable rate basis			30-day U.S. LIBOR
Line of credit facility, maximum borrowing capacity		$ 15,000,000
Silicon Valley Bank , MidCap Funding XII Trust and MidCap Financial Trust | Floating Interest Rate | Amended and Restated Loan and Security Agreement
Debt Instrument [Line Items]
Interest rate		7.00%

Long-Term Debt - Scheduled Paym

Long-Term Debt - Scheduled Payments for Loan Agreement (Details) $ in Thousands	Mar. 31, 2018USD ($)
Debt Disclosure [Abstract]
Principal, 2018	$ 2,400
Principal, 2019	3,200
Principal, 2020	1,600
Principal	7,200
Interest and Final Payment, 2018	336
Interest and Final Payment, 2019	234
Interest and Final Payment, 2020	545
Interest and Final Payment	1,115
Total, 2018	2,736
Total, 2019	3,434
Total, 2020	2,145
Total	$ 8,315

Common Stock - Additional Infor

Common Stock - Additional Information (Detail) - $ / shares	Mar. 31, 2018	Dec. 31, 2017
Equity [Abstract]
Common stock, shares authorized	100,000,000	100,000,000
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares outstanding	31,947,033	25,354,651

Stock Purchase Warrants - Addit

Stock Purchase Warrants - Additional Information (Details) - Convertible Stock Warrant - Amended and Restated Loan And Security Agreement - $ / shares	1 Months Ended	3 Months Ended
	Sep. 30, 2016	Mar. 31, 2018
Class Of Warrant Or Right [Line Items]
Class of warrant Exercise	$ 10.74
Warrants expiration term	2026-09
Weighted average remaining life of warrants		8 years 6 months
Maximum
Class Of Warrant Or Right [Line Items]
Number of stock that can be purchased by each warrant	29,796

Share-Based Compensation - Summ

Share-Based Compensation - Summary of Share-based Compensation Expense (Details) - Stock Options - 2011 Stock Incentive Plan, 2016 Equity Incentive Plan - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 1,133	$ 742
Research and Development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-based compensation expense	431	325
General and Administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 702	$ 417

Share-Based Compensation - Su40

Share-Based Compensation - Summary of Activity Related to Stock Options (Details) - Stock Options - $ / shares	3 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of Shares, Options outstanding, Beginning balance	3,075,349
Number of Shares, Granted	142,500
Number of Shares, Exercised	(53,920)
Number of Shares, Forfeited	(28,000)
Number of Shares, Options outstanding, Ending balance	3,135,929
Number of Shares, Options exercisable	1,170,429	1,114,286
Weighted Average Exercise Price, Options outstanding, Beginning balance	$ 6.17
Weighted Average Exercise Price, Granted	6.23
Weighted Average Exercise Price, Exercised	4.40
Weighted Average Exercise Price, Forfeited	7.72
Weighted Average Exercise Price, Options outstanding, Ending balance	6.19
Weighted Average Exercise Price, Options exercisable	$ 4.28	$ 3.94

Share-Based Compensation - Addi

Share-Based Compensation - Additional Information (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
2016 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock purchased	9,692
Share-based compensation expense	$ 5,000	$ 10,000
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized compensation expense related to unvested stock options	$ 11,000
Expected to be recognized over a weighted average period	2 years 10 months 24 days

Commitment and Contingencies -

Commitment and Contingencies - Additional Information (Details)	1 Months Ended	3 Months Ended
	Nov. 30, 2016USD ($)ft²	Mar. 31, 2018USD ($)	Mar. 31, 2017USD ($)
Commitment And Contingencies [Line Items]
Rent expense		$ 58,000	$ 40,000
GEORGIA
Commitment And Contingencies [Line Items]
Area of office leased | ft²	20,000
Operating lease agreement term	6 years 6 months
Operating lease agreement renewal option term	5 years
Minimum monthly lease payments	$ 35,145
Percentage of increase per year	3.00%

Commitment and Contingencies 43

Commitment and Contingencies - Total Future Minimum Commitments Due Under Non-Cancelable Operating Leases (Details) $ in Thousands	Mar. 31, 2018USD ($)
Commitments And Contingencies Disclosure [Abstract]
2,018	$ 326
2,019	444
2,020	458
2,021	472
Thereafter	860
Total minimum lease payments	$ 2,560

License and Collaboration Agr44

License and Collaboration Agreements - Additional Information (Detail) - USD ($)	Jan. 01, 2018	Mar. 31, 2018	Mar. 31, 2017	Mar. 31, 2016	Aug. 31, 2014
Research And Development Arrangement Contract To Perform For Others [Line Items]
License revenue			$ 5,000
Minimum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Other short-term collaboration agreements performance obligations period		1 month
Maximum
Research And Development Arrangement Contract To Perform For Others [Line Items]
Other short-term collaboration agreements performance obligations period		2 months
ASU 2014-09
Research And Development Arrangement Contract To Perform For Others [Line Items]
Cumulative adjustment to accumulated deficit	$ 160,000
NovaMedica
Research And Development Arrangement Contract To Perform For Others [Line Items]
License revenue			$ 5,000
Patent expirations period		2,027
NovaMedica | ASU 2014-09
Research And Development Arrangement Contract To Perform For Others [Line Items]
Cumulative adjustment to accumulated deficit	$ 160,000
NovaMedica | Upfront payment
Research And Development Arrangement Contract To Perform For Others [Line Items]
Deferred revenue				$ 200,000	$ 200,000

Available-for-Sale Investment45

Available-for-Sale Investments - Summary of Company's Available-For-Sale Investments (Details) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	$ 16,222
Unrealized Losses	(1)
Fair Value	16,221	$ 28,416
Government Bonds
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	1,000
Fair Value	1,000
Commercial Paper
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	14,472
Fair Value	14,472
Corporate Bonds
Schedule of Available-for-sale Securities [Line Items]
Amortized Cost	750
Unrealized Losses	(1)
Fair Value	$ 749

Fair Value Measurements - Addit

Fair Value Measurements - Additional Information (Detail) - USD ($)	3 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Fair Value Disclosures [Abstract]
Short-term investments maturity start period	90 days
Short-term investments maturity end period	365 days
Significant transfers between Levels 1, 2 and 3	$ 0	$ 0

Fair Value Measurements - Summa

Fair Value Measurements - Summary of Assets Measured at Fair Value (Detail) - USD ($) $ in Thousands	Mar. 31, 2018	Dec. 31, 2017
Financial Assets:
Total financial assets	$ 101,415	$ 38,000
Corporate Bonds
Financial Assets:
Total financial assets	749	5,064
Commercial Paper
Financial Assets:
Total financial assets	32,776	10,154
Cash and Money Markets
Financial Assets:
Total financial assets	66,530	9,224
Restricted Cash Money Market
Financial Assets:
Total financial assets	360	360
Government Bonds
Financial Assets:
Total financial assets	1,000	11,238
Certificates of Deposit
Financial Assets:
Total financial assets		1,960
Level 1
Financial Assets:
Total financial assets	67,890	20,822
Level 1 | Cash and Money Markets
Financial Assets:
Total financial assets	66,530	9,224
Level 1 | Restricted Cash Money Market
Financial Assets:
Total financial assets	360	360
Level 1 | Government Bonds
Financial Assets:
Total financial assets	1,000	11,238
Level 2
Financial Assets:
Total financial assets	33,525	17,178
Level 2 | Corporate Bonds
Financial Assets:
Total financial assets	749	5,064
Level 2 | Commercial Paper
Financial Assets:
Total financial assets	$ 32,776	10,154
Level 2 | Certificates of Deposit
Financial Assets:
Total financial assets		$ 1,960

Net Loss Per Share - Potential

Net Loss Per Share - Potential Common Stock Equivalents Excluded from Computation of Diluted Net Loss per Share (Details) - shares	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	3,165,725	2,208,888
Outstanding Stock Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	3,135,929	2,179,092
Stock Purchase Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	29,796	29,796

Subsequent Event - Additional I

Subsequent Event - Additional Information (Details) - Subsequent Event	May 08, 2018
Subsequent Event [Line Items]
Initial agreement term	5 years
Agreement successive renewal terms	3 years