Soliton (SOLY) 10-K 29 Mar 19 2018 FY Annual report Financial data

Document And Entity Information

Document And Entity Information - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Mar. 27, 2019	Jun. 30, 2018
Document Information [Line Items]
Entity Registrant Name	Soliton, Inc.
Entity Central Index Key	0001548187
Trading Symbol	soly
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Current Reporting Status	No
Entity Voluntary Filers	No
Entity Well-known Seasoned Issuer	No
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Small Business	true
Entity Common Stock, Shares Outstanding (in shares)		14,613,000
Entity Public Float			$ 0
Entity Shell Company	false
Document Type	10-K
Document Period End Date	Dec. 31, 2018
Document Fiscal Year Focus	2018
Document Fiscal Period Focus	FY
Amendment Flag	false

Balance Sheets

Balance Sheets - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 133,435	$ 18,412
Prepaid expenses and other current assets	10,533	7,746
Total current assets	143,968	26,158
Deferred direct issuance costs - offering	276,560
Property and equipment, net of accumulated depreciation	1,014,240	336,726
Intangible assets, net of accumulated amortization	84,942	92,102
Other assets	23,283	23,283
Total assets	1,542,993	478,269
Current liabilities:
Accounts payable	2,737,836	445,453
Accrued liabilities	1,863,874	853,443
Dividends payable	4,613,260	3,333,260
Accrued interest	133,804
Accrued interest - related party	1,162,719	295,830
Convertible notes payable, net	1,784,976
Convertible notes payable - related party	8,422,000	6,025,000
Notes payable, net	293,568
Notes payable – related party, net	65,479
Deferred rent - current portion	7,106
Total current liabilities	21,084,622	10,952,986
Deferred rent	16,256	25,878
Total liabilities	21,100,878	10,978,864
Commitments and contingencies
Stockholders’ deficit
Common stock, $0.001 par value, 100,000,000 authorized, 1,998,056 and 1,820,556 shares issued and outstanding, respectively	1,998	1,821
Additional paid-in capital	22,568,857	21,031,388
Accumulated deficit	(42,131,275)	(31,536,339)
Total stockholders’ deficit	(19,557,885)	(10,500,595)
Total liabilities and stockholders’ deficit	1,542,993	478,269
Series A Preferred Stock [Member]
Stockholders’ deficit
Preferred stock	417	417
Series B Preferred Stock [Member]
Stockholders’ deficit
Preferred stock	$ 2,118	$ 2,118

Balance Sheets (Parentheticals)

Balance Sheets (Parentheticals) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Preferred stock, par value (in dollars per share)	$ 0.001
Preferred stock, shares designated (in shares)	2,534,766
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized (in shares)	100,000,000	100,000,000
Common stock, shares issued (in shares)	1,998,056	1,820,556
Common stock, shares outstanding (in shares)	1,998,056	1,820,556
Series A Preferred Stock [Member]
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, liquidation value	$ 1,999,997	$ 1,999,997
Preferred stock, shares designated (in shares)	416,666	416,666
Preferred stock, shares issued (in shares)	416,666	416,666
Preferred stock, shares outstanding (in shares)	416,666	416,666
Series B Preferred Stock [Member]
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, liquidation value	$ 14,000,641	$ 14,000,641
Preferred stock, shares designated (in shares)	2,118,100	2,118,100
Preferred stock, shares issued (in shares)	2,118,100	2,118,100
Preferred stock, shares outstanding (in shares)	2,118,100	2,118,100

Statements of Operations

Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Revenue
Operating expenses:
Research and development	4,669,747	3,965,276
Sales and marketing	304,601	91,288
Depreciation and amortization expense	120,488	130,075
General and administrative expenses	3,107,813	3,001,969
Total operating expenses	8,202,649	7,188,608
Loss from operations	(8,202,649)	(7,188,608)
Other (expense) income:
Interest expense	(1,115,501)	(295,830)
Other income	3,214	3,814
Total other (expense) income	(1,112,287)	(292,016)
Loss before income taxes	(9,314,936)	(7,480,624)
Income tax expense	0	0
Net loss	(9,314,936)	(7,480,624)
Dividends to Series A and Series B preferred stockholders	(1,280,000)	(1,280,000)
Net loss attributable to common stockholders	$ (10,594,936)	$ (8,760,624)
Net loss per common share, basic and diluted (in dollars per share)	$ (5.64)	$ (5.15)
Weighted average number of common shares outstanding, basic and diluted (in shares)	1,877,775	1,700,275

Statements of Stockholders' Equ

Statements of Stockholders' Equity - USD ($)	Preferred Stock [Member]Series A Preferred Stock [Member]	Preferred Stock [Member]Series B Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Balance (in shares) at Dec. 31, 2016	416,666	2,118,100	1,643,056
Balance at Dec. 31, 2016	$ 417	$ 2,118	$ 1,643	$ 20,445,460	$ (22,775,715)	$ (2,326,077)
Share-based compensation (in shares)			177,500
Share-based compensation			$ 178	585,928		586,106
Accrued preferred dividends					(1,280,000)	(1,280,000)
Net loss					(7,480,624)	(7,480,624)
Capital contributions – debt forgiveness
Balance (in shares) at Dec. 31, 2017	416,666	2,118,100	1,820,556
Balance at Dec. 31, 2017	$ 417	$ 2,118	$ 1,821	21,031,388	(31,536,339)	(10,500,595)
Share-based compensation (in shares)			177,500
Share-based compensation			$ 177	938,007		938,184
Accrued preferred dividends					(1,280,000)	(1,280,000)
Net loss					(9,314,936)	(9,314,936)
Debt discount on convertible notes and notes payable – issuance of warrants				466,754		466,754
Capital contributions – debt forgiveness				132,708		132,708
Balance (in shares) at Dec. 31, 2018	416,666	2,118,100	1,998,056
Balance at Dec. 31, 2018	$ 417	$ 2,118	$ 1,998	$ 22,568,857	$ (42,131,275)	$ (19,557,885)

Statements of Cash Flows

Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (9,314,936)	$ (7,480,624)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	120,488	130,075
Share-based compensation	938,184	586,106
Write-down of intangible assets	19,138
Amortization of debt discount	111,537
Changes in operating assets – (Increase)/Decrease:
Prepaid expenses and other current assets	(2,787)	25,817
Changes in operating liabilities – Increase/(Decrease):
Accounts payable	1,387,383	10,057
Accrued liabilities	1,143,139	335,213
Accrued interest – non-related party	133,804
Accrued interest – related party	866,889	295,830
Deferred rent	(2,516)	1,978
NET CASH USED IN OPERATING ACTIVITIES:	(4,599,677)	(6,095,548)
CASH FLOWS FROM INVESTING ACTIVITIES:
Payments for the purchase of property and equipment	(17,626)	(48,807)
Payments for acquisition of intangibles	(12,354)	(18,125)
NET CASH USED IN INVESTING ACTIVITIES:	(29,980)	(66,932)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from issuance of convertible notes – related party	2,397,000
Proceeds from issuance of convertible notes, net	1,814,240
Proceeds from issuance of non-convertible notes – related party	125,000	6,025,000
Proceeds from issuance of non-convertible notes	560,000
Payment of deferred direct issuance costs – proposed offering	(151,560)
NET CASH PROVIDED BY FINANCING ACTIVITIES:	4,744,680	6,025,000
Net increase (decrease) in cash and cash equivalents	115,023	(137,480)
Cash and cash equivalents, beginning of period	18,412	155,892
Cash and cash equivalents, end of period	133,435	18,412
Supplemental cash flow disclosures:
Cash paid for interest
Cash paid for income taxes
Non-cash investing and financing activities:
Accrued direct issuance costs – offering	125,000
Property and equipment acquired through accounts payable	780,000
Capital contributions – debt forgiveness	132,708
Accrued preferred dividends	1,280,000	1,280,000
Debt discount on convertible notes and notes payable – issuance of warrants	$ 466,754

Note 1 - Background and Organiz

Note 1 - Background and Organization and Going Concern	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]	1. Background, Organization and Going Concern Soliton, Inc. (the “Company”) was organized under the laws of the State of Delaware on March 27, 2012. Initial Public Offering On February 19, 2019, 2,172,591 $5.00 $10,862,955 $9,700,000. $11,784,987 6,825,391 $4,773,480 954,696 2,534,766 127,500 14,613,000. not 4.99% 4.99% $47,781 273,034 not 4.99% not Going Concern The Company is an early stage and emerging growth company and has not not For the years ended December 31, 2018 2017, $10,594,936 $8,760,624, $4,599,677 $6,095,548, December 31, 2018, $42,131,275, $20,940,654 $133,435. not one not The Company’s cash on hand of $5,885,411 March 22, 2019 not February 2020. no

Note 2 - Summary of Significant

Note 2 - Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Significant Accounting Policies [Text Block]	2. Summary of Significant Accounting Policies Basis of Presentation The accompanying annual financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) and the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”). Segments The Company operates in one Use of Estimates in Financial Statement Presentation The preparation of these financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. The Company's significant estimates and assumptions include valuation of equity related instruments, depreciable lives of long-lived assets (including property and equipment and intangible assets), and the valuation allowance related to deferred taxes. Some of these judgments can be subjective and complex, and, consequently, actual results could differ from those estimates. Although the Company believes that its estimates and assumptions are reasonable, they are based upon information available at the time the estimates and assumptions were made. Actual results could differ from those estimates. Cash and Cash Equivalents The Company considers all highly liquid accounts with original maturities of three $250,000 may $250,000. Property and Equipment Property and equipment are stated at historical cost and depreciated on a straight-line basis over the estimated useful lives, generally three five Intangible Assets Intangible assets include patents and trademarks. Patent related costs in connection with filing and prosecuting patent applications and patents filed by the Company are expensed as incurred and are classified as research and development expenses. The Company does not may Long-Lived Assets The Company evaluates its long-lived assets, including equipment, for impairment whenever events or changes in circumstances indicate that the carrying value of these assets may not Convertible Debt When conversion terms related to convertible debt would be triggered by future events not Operating and Capital Leases The Company has one not December 31, 2018. Fair Value Measurements Fair value is defined as the price which would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. A three Level 1 Level 2 1 not Level 3 At December 31, 2018 2017, At December 31, 2018 2017, not 820, Revenue Recognition Beginning from January 1, 2019, Research and Development Expenses Research and development expenses are recognized as incurred and include the costs related to the Company's various contract research service providers, suppliers, engineering studies, supplies, outsourced testing and consulting, clinical costs, and salaries and related costs of employees working directly on research activities. Stock-Based Compensation Stock-based compensation expense includes the estimated fair value of equity awards vested during the reporting period. The expense for equity awards vested during the reporting period is determined based upon the grant date fair value of the award and is recognized as expense over the applicable vesting period of the stock award using the straight-line method. Income Taxes The Company uses the asset and liability method of accounting for income taxes. Under this method, deferred tax assets and liabilities are determined based on the differences between the financial reporting and the tax bases of reported assets and liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. The Company must then assess the likelihood that the resulting deferred tax assets will be realized. A valuation allowance is provided when it is more likely than not not Management has evaluated and concluded that there were no December 31, 2018. not twelve The Company classified interest expense and any related penalties related to income tax uncertainties as a component of income tax expense. No 2018 2017. Net Loss per Common Share Basic net loss per common share are computed by dividing net loss available to common stockholders by the weighted-average number of common shares outstanding during the period. Diluted net loss per common share is determined using the weighted-average number of common shares outstanding during the period, adjusted for the dilutive effect of common stock equivalents. In periods when losses are reported, the weighted-average number of common shares outstanding excludes common stock equivalents, because their inclusion would be anti-dilutive. As of December 31, 2018 2017, 2,235,000 15,000 2,534,766 127,500 305,000 776,350 0 JOBS Act Accounting Election The Company is an emerging growth company ("EGC"), as defined in the Jumpstart Our Business Startups Act of 2012 not may Subsequent Events The Company’s management reviewed all material events through the date that the financial statements were issued for subsequent event disclosure consideration as discussed in Note 10 Recent Accounting Standards In February 2016 No. 2016 02, Leases (Topic 842 one December 15, 2019 first January 1, 2020. July 2018 2018 11, Leases (Topic 842 2018 11. 2016 02 7 not 2016 02 In June 2018, No. 2018 07, 718 January 1, 2020. not not December 31, 2018. The Company does not not

Note 3 - Deferred Direct Issuan

Note 3 - Deferred Direct Issuance Costs - Offering	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Deferred Direct Issuance Costs, Proposed Offering [Text Block]	3. Deferred Direct Issuance Costs – Offering As of December 31, 2018, $276,560, February 2019.

Note 4 - Property and Equipment

Note 4 - Property and Equipment	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Property, Plant and Equipment Disclosure [Text Block]	4. Property and Equipment Property and equipment consisted of the following: December 31, 2018 December 31, 2017 Computer equipment and software $ 105,704 $ 95,130 Lab equipment 1,024,480 241,377 Leasehold improvements 242,167 242,167 Furniture 19,893 19,893 Subtotal 1,392,244 598,567 Less: accumulated depreciation (378,004 ) (261,841 ) Total property and equipment $ 1,014,240 $ 336,726 As of December 31, 2018, $680,000 2019. Depreciation expense for the years ended December 31, 2018 2017 $120,112 $128,587,

Note 5 - Intangible Assets

Note 5 - Intangible Assets	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Intangible Assets Disclosure [Text Block]	5. Intangible Assets The carrying amount and accumulated amortization of intangible assets are as follows: December 31, 2018 December 31, 2017 Patents $ - $ 22,527 Trademarks 84,942 72,590 Subtotal 84,942 95,117 Less: accumulated amortization - (3,015 ) Total intangible assets, net $ 84,942 $ 92,102 During the year ended December 31, 2018, $19,138. December 31, 2018 2017 $376 $1,488,

Note 6 - Notes Payable

Note 6 - Notes Payable	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Debt Disclosure [Text Block]	6. Notes Payable On January 18, 2017, $3,000,000 75% not $5,000,000 85% 8.25% January 31, 2018, 12.0% The Company closed the initial tranche of the First Note on January 23, 2017 $1,000,000, March 1, 2017 $1,000,000 April 27, 2017 $1,000,000. On June 19, 2017, first $3,250,000 $6,250,000. The Company closed $1,300,000 June 19, 2017 $700,000 July 17, 2017. No As of December 31, 2018, $5,000,000 On November 1, 2017, second $1,900,000 75% not $5,000,000 85% 8.25% June 29, 2018, 12.0% The Company closed the initial tranche of the Second Note on November 9, 2017 $400,000, December 1, 2017, $375,000, third December 26, 2017 $250,000, fourth January 8, 2018 $250,000, fifth January 25, 2018 $250,000 February 13, 2018 $375,000 $1,900,000. On June 29, 2018, April 30, 2019. As of December 31, 2018, $1,900,000 On April 2, 2018, August 10, 2018, $500,000 $0.175. not 4.99% 10.0% April 2, 2020. As of December 31, 2018, $500,000. $250,000 $250,000 four On April 17, 2018, $3,000,000 $1.75. 10.0% two As of December 31, 2018, $3,000,000. $1,272,000 $1,728,000 The Company incurred issuance costs relating to the Fourth Note in the amount of $163,760, 24 December 31, 2018, $118,492. The Company also issued warrants to purchase 91,350 $1.75 $103,006, 24 December 31, 2018, $74,532. On August 7, 2018, $485,000 10% five one $1.75 five $125,000 one On August 31, 2018, $200,000 August 7, 2018. December 21, 2018, $300,000 August 7, 2018 $985,000. October 2018 February 2019, $125,000 $860,000 February 15, 2019, $1,005,039 The Company issued 685,000 2018. $775,616. $363,748 $66,423 $297,325 24 December 31, 2018, $59,521 $266,432, The following table summarizes convertible notes payable and interest as of December 31, 2018: Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest First Note 8.25 % 12.00% $ 5,000,000 $ — $ 5,000,000 Second Note 8.25 % 12.00% 1,900,000 — 1,900,000 Third Note 10.00 % 10.00% 250,000 250,000 500,000 Fourth Note 10.00 % 10.00% 1,272,000 1,728,000 3,000,000 Total $ 8,422,000 $ 1,160,555 $ 1,978,000 $ 126,529 $ 10,400,000 $ 1,287,084 Unamortized Discount — — (193,024 ) — (193,024 ) — Total, Net $ 8,422,000 $ 1,160,555 $ 1,784,976 $ 126,529 $ 10,206,976 $ 1,287,084 The following table summarizes convertible notes payable and interest as of December 31, 2017: Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest First Note 8.25 % 12.00% $ 5,000,000 $ — $ 5,000,000 Second Note 8.25 % 12.00% 1,025,000 — 1,025,000 Total $ 6,025,000 $ 295,830 $ — $ — $ 6,025,000 $ 295,830 The following table summarizes non-convertible notes payable and interest as of December 31, 2018: Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest Fifth Note 10.00 % 10.00% $ 125,000 $ 560,000 $ 685,000 Total $ 125,000 $ 2,164 $ 560,000 $ 7,275 $ 685,000 $ 9,439 Unamortized Discount (59,521 ) — (266,432 ) — (325,953 ) — Total, Net $ 65,479 $ 2,164 $ 293,568 $ 7,275 $ 359,047 $ 9,439 During the years ended December 31, 2018 2017, $1,000,693 $295,830,

Note 7 - Commitments and Contin

Note 7 - Commitments and Contingencies	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Commitments Contingencies and Guarantees [Text Block]	7. Commitments and Contingencies On April 5, 2012, 30 third MD Anderson has the right to terminate the agreement upon advanced notice in the event of a default by Soliton. The agreement will expire upon the expiration of the licensed intellectual property. The rights obtained by the Company pursuant to the agreement are made subject to the rights of the U.S. government to the extent that the technology covered by the licensed intellectual property was developed under a funding agreement between MD Anderson and the U.S. government. All out-of-pocket expenses incurred by MD Anderson in filing, prosecuting and maintaining the licensed patents have been and shall continue to be assumed by the Company. For the years ended December 31, 2018 2017, $55,000 $45,000, Leases The Company leases space for its corporate office, which provides for a five July 15, 2015, $8,053 December 31, 2018 2017 $89,643 $96,631, Future minimum lease payments as of December 31, 2018 Year Ending December, 31 Amount 2019 103,737 2020 108,429 Thereafter 36,668 Total future minimum lease payments $ 248,834 Legal Proceedings In the normal course of business, from time-to-time, the Company may not

Note 8 - Stockholders' Deficit

Note 8 - Stockholders' Deficit	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Stockholders' Equity Note Disclosure [Text Block]	8. Stockholders’ Deficit Preferred Stock As of December 31, 2018, 2,534,766 $0.001 may As of December 31, 2018 2017, 416,666 2,118,100 The Series A preferred stock has the following features: 1. Dividends accrue at a rate of 8% $4.80 $24.00 $50,000,000 50.1% 2. A liquidation right preferable over the right of the Company’s common stock. 3. Each share of the Series A preferred stock has one 4. Each share of the Series A preferred stock is convertible by the holder, at any time, into shares of common stock equal to $4.80 $4.80. The Series B preferred stock has similar rights as Series A preferred stock except that the dividends are based on $6.61 $6.61 $6.61. December 31, 2018 2017, $4,613,260 $3,333,260, December 31, 2018, $4.80 $6.61, All outstanding shares of Series A and Series B preferred stock and accrued dividends on these shares were converted into common stock upon the Company’s IPO on February 14, 2019. February 19, 2019 no Adoption of 2012 In November 2012, 2012 “2012 2012 may 2012 2012 2012 789,745 December 31, 2018, 14,745 2012 Adoption of 2018 In June 2018, 2018 2018 may 2018 2018 2018 3,000,000 December 31, 2018, 780,000 2018 Restricted Stock During the years ended December 31, 2018 2017, $533,550 $570,536, December 31, 2018 2017, 177,500 December 31, 2018, 127,500 December 31, 2018, $264,451. Stock Options The following table summarizes stock option activities for the years ended December 31, 2018: Number of Shares Weighted Average Exercise Price Weighted Average Remaining Life (in Years) Aggregate Intrinsic Value Outstanding, December 31, 2016 — $ — $ — Granted 15,000 0.13 Outstanding, December 31, 2017 15,000 0.13 9.75 — Granted 2,220,000 1.75 Outstanding, December 31, 2018 2,235,000 1.74 9.44 $ 23,100 Exercisable, December 31, 2018 7,500 $ 0.13 8.76 $ 11,550 During the year ended December 31, 2018, 2,220,000 $1.75 10 4 $2,694,567 1 2.77% 2 6.25 3 84.5% 84.7% 4 no 5 $1.67 On October 1, 2017, 15,000 ten $0.13 3,750 3,750 $46,711 1 1.92% 2 5.75 3 79.0% 4 no 5 $3.21 All options issued and outstanding are being amortized over their respective vesting periods. The unrecognized compensation expense at December 31, 2018 $2,321,072. December 31, 2018 2017, $404,635 $15,570, Warrants On April 20, 2018, 79,350 $1.75. April 20, 2023. On June 8, 2018, 12,000 $1.75. June 8, 2023. From October December 2018, 685,000 $1.75. five The grant date fair value of these 776,350 $878,622, 1 2.8% 3.05% 2 5 3 84% 86% 4 no 5 $1.67 The fair value amount was included in discounts on convertible notes payable and notes payable, which were amortized over the life of the debt. At December 31, 2018, $400,485. During the year ended December 31, 2018, $66,269. The following table summarizes warrant activities for the year ended December 31, 2018: Number of Shares Weighted Average Exercise Price Weighted Average Remaining Contractual Term (in Years) Aggregate Intrinsic Value Outstanding, December 31, 2017 — $ — — $ — Granted 776,350 1.75 Exercised — — Canceled — — Outstanding, December 31, 2018 776,350 $ 1.75 4.80 $ — Exercisable, December 31, 2018 776,350 $ 1.75 4.80 $ — During the year ended December 31, 2018, $132,708 2015 2018

Note 9 - Income Taxes

Note 9 - Income Taxes	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Income Tax Disclosure [Text Block]	9. Income Taxes On December 22, 2017, not 1 35 21 2 3 4 December 31, 2017; ( 5 6 100% $3.4 December 31, 2017. no The Company files U.S. federal and various U.S. state income tax returns. Due to the Company’s losses, there was no December 31, 2018 2017. The income tax provision differs from the amount using the statutory federal income tax rate of 21% 2018 34% 2017 December 31, 2018 December 31, 2017 Amount % Amount % Tax benefit at the U.S. federal statutory rate $ (1,956,137 ) (21.00 %) $ (2,543,412 ) (34.00 %) Tax rate change — — 3,391,624 45.34 % Permanent differences 119,266 1.28 % 8,908 0.11 % Return to provision (94,219 ) (1.01 %) (92,256 ) (1.23 %) Valuation allowance 1,931,090 20.73 % (764,864 ) (10.23 %) Effective income tax rate $ — — % $ — — % The effective income tax rate varied from the statutory rate in 2018 2017 Deferred tax assets and liabilities consist of the following: December 31, 2018 December 31, 2017 Assets related to: Accounts payable and accrued liabilities $ 1,224,599 $ 325,560 Net operating losses 6,240,595 5,192,813 Total deferred tax assets 7,465,194 5,518,373 Valuation allowance for deferred tax assets (7,409,867 ) (5,478,777 ) Net deferred tax 55,327 39,596 Liabilities related to: Accounts receivable and prepaid expenses (27,976 ) (665 ) Depreciation and amortization of property and equipment and intangibles (27,351 ) (38,931 ) Net deferred tax liabilities (55,327 ) (39,596 ) Net deferred tax assets $ — $ — The Company has federal net operating loss (“NOL”) carryforwards of approximately $24.7 2036. $5.0 2018. not 80% The Company has recorded a full valuation allowance against its net total deferred tax assets as of December 31, 2018 2017 not not not not During the year ended December 31, 2018, $1.9

Note 10 - Subsequent Events

Note 10 - Subsequent Events	12 Months Ended
	Dec. 31, 2018
Notes to Financial Statements
Subsequent Events [Text Block]	Note 10 In January 2019, one $484,000 September 30, 2018, February 5, 2019, 401,750 $1.75 10 four In January February 2019, $300,000 10% five one $1.75. On February 19, 2019, 1. On February 19, 2019, no 100,000,000. On February 26, 2019, 2019, one $25,000 On March 4, 2019, March 18, 2019, 510 On March 12, 2019, $ 60,000 $70,000; $30,000. On March 20, 2019, $200,000 March 20, 2020. March 29, 2019,

Significant Accounting Policies

Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2018
Accounting Policies [Abstract]
Basis of Accounting, Policy [Policy Text Block]	Basis of Presentation The accompanying annual financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) and the rules and regulations of the U.S. Securities and Exchange Commission (“SEC”).
Segment Reporting, Policy [Policy Text Block]	Segments The Company operates in one
Use of Estimates, Policy [Policy Text Block]	Use of Estimates in Financial Statement Presentation The preparation of these financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. The Company's significant estimates and assumptions include valuation of equity related instruments, depreciable lives of long-lived assets (including property and equipment and intangible assets), and the valuation allowance related to deferred taxes. Some of these judgments can be subjective and complex, and, consequently, actual results could differ from those estimates. Although the Company believes that its estimates and assumptions are reasonable, they are based upon information available at the time the estimates and assumptions were made. Actual results could differ from those estimates.
Cash and Cash Equivalents, Policy [Policy Text Block]	Cash and Cash Equivalents The Company considers all highly liquid accounts with original maturities of three $250,000 may $250,000.
Property, Plant and Equipment, Policy [Policy Text Block]	Property and Equipment Property and equipment are stated at historical cost and depreciated on a straight-line basis over the estimated useful lives, generally three five
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]	Intangible Assets Intangible assets include patents and trademarks. Patent related costs in connection with filing and prosecuting patent applications and patents filed by the Company are expensed as incurred and are classified as research and development expenses. The Company does not may
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]	Long-Lived Assets The Company evaluates its long-lived assets, including equipment, for impairment whenever events or changes in circumstances indicate that the carrying value of these assets may not
Debt, Policy [Policy Text Block]	Convertible Debt When conversion terms related to convertible debt would be triggered by future events not
Lessee, Leases [Policy Text Block]	Operating and Capital Leases The Company has one not December 31, 2018.
Fair Value Measurement, Policy [Policy Text Block]	Fair Value Measurements Fair value is defined as the price which would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. A three Level 1 Level 2 1 not Level 3 At December 31, 2018 2017, At December 31, 2018 2017, not 820,
Revenue from Contract with Customer [Policy Text Block]	Revenue Recognition Beginning from January 1, 2019,
Research and Development Expense, Policy [Policy Text Block]	Research and Development Expenses Research and development expenses are recognized as incurred and include the costs related to the Company's various contract research service providers, suppliers, engineering studies, supplies, outsourced testing and consulting, clinical costs, and salaries and related costs of employees working directly on research activities.
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]	Stock-Based Compensation Stock-based compensation expense includes the estimated fair value of equity awards vested during the reporting period. The expense for equity awards vested during the reporting period is determined based upon the grant date fair value of the award and is recognized as expense over the applicable vesting period of the stock award using the straight-line method.
Income Tax, Policy [Policy Text Block]	Income Taxes The Company uses the asset and liability method of accounting for income taxes. Under this method, deferred tax assets and liabilities are determined based on the differences between the financial reporting and the tax bases of reported assets and liabilities and are measured using the enacted tax rates and laws that will be in effect when the differences are expected to reverse. The Company must then assess the likelihood that the resulting deferred tax assets will be realized. A valuation allowance is provided when it is more likely than not not Management has evaluated and concluded that there were no December 31, 2018. not twelve The Company classified interest expense and any related penalties related to income tax uncertainties as a component of income tax expense. No 2018 2017.
Earnings Per Share, Policy [Policy Text Block]	Net Loss per Common Share Basic net loss per common share are computed by dividing net loss available to common stockholders by the weighted-average number of common shares outstanding during the period. Diluted net loss per common share is determined using the weighted-average number of common shares outstanding during the period, adjusted for the dilutive effect of common stock equivalents. In periods when losses are reported, the weighted-average number of common shares outstanding excludes common stock equivalents, because their inclusion would be anti-dilutive. As of December 31, 2018 2017, 2,235,000 15,000 2,534,766 127,500 305,000 776,350 0
JOBS Act Accounting Election [Policy Text Block]	JOBS Act Accounting Election The Company is an emerging growth company ("EGC"), as defined in the Jumpstart Our Business Startups Act of 2012 not may
Subsequent Events, Policy [Policy Text Block]	Subsequent Events The Company’s management reviewed all material events through the date that the financial statements were issued for subsequent event disclosure consideration as discussed in Note 10
New Accounting Pronouncements, Policy [Policy Text Block]	Recent Accounting Standards In February 2016 No. 2016 02, Leases (Topic 842 one December 15, 2019 first January 1, 2020. July 2018 2018 11, Leases (Topic 842 2018 11. 2016 02 7 not 2016 02 In June 2018, No. 2018 07, 718 January 1, 2020. not not December 31, 2018. The Company does not not

Note 4 - Property and Equipme_2

Note 4 - Property and Equipment (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Property, Plant and Equipment [Table Text Block]	December 31, 2018 December 31, 2017 Computer equipment and software $ 105,704 $ 95,130 Lab equipment 1,024,480 241,377 Leasehold improvements 242,167 242,167 Furniture 19,893 19,893 Subtotal 1,392,244 598,567 Less: accumulated depreciation (378,004 ) (261,841 ) Total property and equipment $ 1,014,240 $ 336,726

Note 5 - Intangible Assets (Tab

Note 5 - Intangible Assets (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Schedule of Intangible Assets and Goodwill [Table Text Block]	December 31, 2018 December 31, 2017 Patents $ - $ 22,527 Trademarks 84,942 72,590 Subtotal 84,942 95,117 Less: accumulated amortization - (3,015 ) Total intangible assets, net $ 84,942 $ 92,102

Note 6 - Notes Payable (Tables)

Note 6 - Notes Payable (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Schedule of Long-term Debt Instruments [Table Text Block]	Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest First Note 8.25 % 12.00% $ 5,000,000 $ — $ 5,000,000 Second Note 8.25 % 12.00% 1,900,000 — 1,900,000 Third Note 10.00 % 10.00% 250,000 250,000 500,000 Fourth Note 10.00 % 10.00% 1,272,000 1,728,000 3,000,000 Total $ 8,422,000 $ 1,160,555 $ 1,978,000 $ 126,529 $ 10,400,000 $ 1,287,084 Unamortized Discount — — (193,024 ) — (193,024 ) — Total, Net $ 8,422,000 $ 1,160,555 $ 1,784,976 $ 126,529 $ 10,206,976 $ 1,287,084 Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest First Note 8.25 % 12.00% $ 5,000,000 $ — $ 5,000,000 Second Note 8.25 % 12.00% 1,025,000 — 1,025,000 Total $ 6,025,000 $ 295,830 $ — $ — $ 6,025,000 $ 295,830 Interest Rate Related Party Non-Related Party Total Initial Post-Maturity Principal Interest Principal Interest Principal Interest Fifth Note 10.00 % 10.00% $ 125,000 $ 560,000 $ 685,000 Total $ 125,000 $ 2,164 $ 560,000 $ 7,275 $ 685,000 $ 9,439 Unamortized Discount (59,521 ) — (266,432 ) — (325,953 ) — Total, Net $ 65,479 $ 2,164 $ 293,568 $ 7,275 $ 359,047 $ 9,439

Note 7 - Commitments and Cont_2

Note 7 - Commitments and Contingencies (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Schedule of Future Minimum Rental Payments for Operating Leases [Table Text Block]	Year Ending December, 31 Amount 2019 103,737 2020 108,429 Thereafter 36,668 Total future minimum lease payments $ 248,834

Note 8 - Stockholders' Deficit

Note 8 - Stockholders' Deficit (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Share-based Compensation, Stock Options, Activity [Table Text Block]	Number of Shares Weighted Average Exercise Price Weighted Average Remaining Life (in Years) Aggregate Intrinsic Value Outstanding, December 31, 2016 — $ — $ — Granted 15,000 0.13 Outstanding, December 31, 2017 15,000 0.13 9.75 — Granted 2,220,000 1.75 Outstanding, December 31, 2018 2,235,000 1.74 9.44 $ 23,100 Exercisable, December 31, 2018 7,500 $ 0.13 8.76 $ 11,550
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]	Number of Shares Weighted Average Exercise Price Weighted Average Remaining Contractual Term (in Years) Aggregate Intrinsic Value Outstanding, December 31, 2017 — $ — — $ — Granted 776,350 1.75 Exercised — — Canceled — — Outstanding, December 31, 2018 776,350 $ 1.75 4.80 $ — Exercisable, December 31, 2018 776,350 $ 1.75 4.80 $ —

Note 9 - Income Taxes (Tables)

Note 9 - Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2018
Notes Tables
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]	December 31, 2018 December 31, 2017 Amount % Amount % Tax benefit at the U.S. federal statutory rate $ (1,956,137 ) (21.00 %) $ (2,543,412 ) (34.00 %) Tax rate change — — 3,391,624 45.34 % Permanent differences 119,266 1.28 % 8,908 0.11 % Return to provision (94,219 ) (1.01 %) (92,256 ) (1.23 %) Valuation allowance 1,931,090 20.73 % (764,864 ) (10.23 %) Effective income tax rate $ — — % $ — — %
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]	December 31, 2018 December 31, 2017 Assets related to: Accounts payable and accrued liabilities $ 1,224,599 $ 325,560 Net operating losses 6,240,595 5,192,813 Total deferred tax assets 7,465,194 5,518,373 Valuation allowance for deferred tax assets (7,409,867 ) (5,478,777 ) Net deferred tax 55,327 39,596 Liabilities related to: Accounts receivable and prepaid expenses (27,976 ) (665 ) Depreciation and amortization of property and equipment and intangibles (27,351 ) (38,931 ) Net deferred tax liabilities (55,327 ) (39,596 ) Net deferred tax assets $ — $ —

Note 1 - Background and Organ_2

Note 1 - Background and Organization and Going Concern (Details Textual) - USD ($)	Feb. 19, 2019	Dec. 31, 2018	Dec. 31, 2017	Mar. 22, 2019	Feb. 18, 2019
Common Stock, Shares, Outstanding, Ending Balance		1,998,056	1,820,556
Net Income (Loss) Available to Common Stockholders, Basic, Total		$ (10,594,936)	$ (8,760,624)
Net Cash Provided by (Used in) Operating Activities, Total		(4,599,677)	(6,095,548)
Retained Earnings (Accumulated Deficit), Ending Balance		(42,131,275)	$ (31,536,339)
Working Capital		(20,940,654)
Cash, Ending Balance		$ 133,435
Subsequent Event [Member]
Stock Issued During Period, Shares, New Issues	2,172,591
Shares Issued, Price Per Share	$ 5
Proceeds from Issuance of Common Stock	$ 10,862,955
Proceeds from Issuance of Common Stock, Net	9,700,000
Debt Conversion, Original Debt, Amount	$ 11,784,987
Debt Conversion, Converted Instrument, Shares Issued	6,825,391
Conversion of Accrued Dividends into Common Stock, Amount Converted	$ 4,773,480
Conversion of Accrued Dividends into Common Stock, Shares Issued	954,696
Common Stock, Shares, Outstanding, Ending Balance	14,613,000				127,500
Debt Instrument, Convertible, Threshold Percentage of Stock Ownership After Conversion	4.99%
Convertible Debt, Total	$ 47,781
Debt Instrument, Convertible, Number of Equity Instruments	273,034
Cash, Ending Balance				$ 5,885,411
Subsequent Event [Member] | Conversion of Preferred Stock into Common Stock [Member]
Conversion of Stock, Shares Issued	2,534,766

Note 2 - Summary of Significa_2

Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Capital Lease Obligations, Total	$ 0
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total	$ 0	$ 0
Employee Stock Option [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	2,235,000	15,000
Convertible Preferred Stocks [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	2,534,766	2,534,766
Restricted Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	127,500	305,000
Convertible Debt Securities [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	776,350	0
Minimum [Member]
Property, Plant and Equipment, Useful Life	3 years
Maximum [Member]
Property, Plant and Equipment, Useful Life	5 years

Note 3 - Deferred Direct Issu_2

Note 3 - Deferred Direct Issuance Costs - Offering (Details Textual)	Dec. 31, 2018USD ($)
Deferred Direct Issuance Costs, Proposed Offering	$ 276,560

Note 4 - Property and Equipme_3

Note 4 - Property and Equipment (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Depreciation, Total	$ 120,112	$ 128,587
Equipment [Member]
Property, Plant and Equipment, Held for Testing	$ 680,000

Note 4 - Property and Equipme_4

Note 4 - Property and Equipment - Property and Equipment (Details) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Property and Equipment, Gross	$ 1,392,244	$ 598,567
Less: accumulated depreciation	(378,004)	(261,841)
Total property and equipment	1,014,240	336,726
Computer Equipment [Member]
Property and Equipment, Gross	105,704	95,130
Equipment [Member]
Property and Equipment, Gross	1,024,480	241,377
Leasehold Improvements [Member]
Property and Equipment, Gross	242,167	242,167
Furniture and Fixtures [Member]
Property and Equipment, Gross	$ 19,893	$ 19,893

Note 5 - Intangible Assets (Det

Note 5 - Intangible Assets (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Impairment of Intangible Assets, Finite-lived	$ 19,138
Amortization of Intangible Assets, Total	$ 376	$ 1,488

Note 5 - Intangible Assets - In

Note 5 - Intangible Assets - Intangible Assets (Details) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Intangible assets, gross	$ 84,942	$ 95,117
Less: accumulated amortization		(3,015)
Total intangible assets, net	84,942	92,102
Patents [Member]
Intangible assets, gross		22,527
Trademarks [Member]
Intangible assets, gross	$ 84,942	$ 72,590

Note 6 - Notes Payable (Details

Note 6 - Notes Payable (Details Textual) - USD ($)	Feb. 28, 2019	Feb. 19, 2019	Feb. 15, 2019	Dec. 21, 2018	Oct. 31, 2018	Aug. 31, 2018	Aug. 10, 2018	Feb. 13, 2018	Jan. 25, 2018	Jan. 08, 2018	Dec. 26, 2017	Dec. 01, 2017	Nov. 09, 2017	Nov. 01, 2017	Jul. 17, 2017	Jun. 19, 2017	Apr. 27, 2017	Mar. 01, 2017	Jan. 23, 2017	Jan. 18, 2017	Feb. 13, 2018	Dec. 31, 2018	Dec. 31, 2017	Aug. 07, 2018	Jun. 08, 2018	Apr. 20, 2018	Apr. 17, 2018
Class of Warrant or Right, Number of Securities Called by Warrants or Rights																						776,350
Class of Warrant or Right, Exercise Price of Warrants or Rights																						$ 1.75
Warrants and Rights Outstanding																						$ 878,622
Interest Expense, Debt, Total																						$ 1,000,693	$ 295,830
Subsequent Event [Member]
Debt Instrument, Convertible, Threshold Percentage of Stock Ownership After Conversion		4.99%
Warrant Issued Under Fourth Note [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights																						91,350			12,000	79,350
Class of Warrant or Right, Exercise Price of Warrants or Rights																						$ 1.75			$ 1.75	$ 1.75
Warrants and Rights Outstanding																						$ 103,006
Debt Instrument, Unamortized Discount, Total																						$ 74,532
Warrant Issued with Fifth Note [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights																								1
Class of Warrant or Right, Exercise Price of Warrants or Rights																								$ 1.75
Warrants and Rights Outstanding, Term																								5 years
Warrants Issued in Connection with Fifth Note [Member]
Class of Warrant or Right, Issued During Period																						685,000
Class of Warrant or Right, Issued During Period, Value																						$ 775,616
Convertible Debt [Member]
Debt Instrument, Unamortized Discount, Total																						193,024
Convertible Debt [Member] | Non-related Party Investors [Member]
Debt Instrument, Unamortized Discount, Total																						$ 193,024
First Note [Member] | Convertible Debt [Member]
Debt Agreement, Maximum Borrowing Capacity																$ 6,250,000				$ 3,000,000
Debt Instrument, Convertible, Percentage of Stock Price, Subsequent Equity Financing Gross Proceeds Note Less Than 5 Million																				75.00%
Debt Instrument, Convertible, Equity Financing Gross Proceeds Trigger																				$ 5,000,000
Debt Instrument, Convertible, Percentage of Stock Price, Fully-diluted Common Shares																				85.00%
Debt Instrument, Interest Rate, Stated Percentage																				8.25%		8.25%	8.25%
Debt Instrument, Interest Rate, Maturity																				12.00%		12.00%	12.00%
Proceeds from Issuance of Long-term Debt, Total															$ 700,000	1,300,000	$ 1,000,000	$ 1,000,000	$ 1,000,000
Debt Agreement, Additional Borrowing Capacity																$ 3,250,000
First Note [Member] | Convertible Debt [Member] | A Single Related Party [Member]
Debt Instrument, Face Amount																						$ 5,000,000
Second Note [Member] | Convertible Debt [Member]
Debt Agreement, Maximum Borrowing Capacity														$ 1,900,000
Debt Instrument, Convertible, Percentage of Stock Price, Subsequent Equity Financing Gross Proceeds Note Less Than 5 Million														75.00%
Debt Instrument, Convertible, Percentage of Stock Price, Fully-diluted Common Shares														85.00%
Debt Instrument, Interest Rate, Stated Percentage														8.25%								8.25%	8.25%
Debt Instrument, Interest Rate, Maturity														12.00%								12.00%	12.00%
Proceeds from Issuance of Long-term Debt, Total								$ 375,000	$ 250,000	$ 250,000	$ 250,000	$ 375,000	$ 400,000								$ 1,900,000
Second Note [Member] | Convertible Debt [Member] | A Single Related Party [Member]
Debt Instrument, Face Amount																						$ 1,900,000
Third Note [Member] | Convertible Debt [Member]
Debt Agreement, Maximum Borrowing Capacity							$ 500,000
Debt Instrument, Interest Rate, Stated Percentage							10.00%															10.00%
Debt Instrument, Interest Rate, Maturity																						10.00%
Debt Instrument, Face Amount																						$ 500,000
Debt Instrument, Convertible, Conversion Price							$ 0.175
Debt Instrument, Convertible, Threshold Percentage of Stock Ownership After Conversion							4.99%
Third Note [Member] | Convertible Debt [Member] | Non-related Party Investors [Member]
Debt Instrument, Face Amount																						250,000
Third Note [Member] | Convertible Debt [Member] | A Single Related Party [Member]
Debt Instrument, Face Amount																						$ 250,000
Fourth Note [Member] | Convertible Debt [Member]
Debt Agreement, Maximum Borrowing Capacity																											$ 3,000,000
Debt Instrument, Interest Rate, Stated Percentage																						10.00%					10.00%
Debt Instrument, Interest Rate, Maturity																						10.00%
Debt Instrument, Face Amount																											$ 3,000,000
Debt Instrument, Convertible, Conversion Price																											$ 1.75
Debt Issuance Costs, Gross																						$ 163,760
Debt Issuance Costs, Net, Total																						118,492
Fourth Note [Member] | Convertible Debt [Member] | Non-related Party Investors [Member]
Debt Instrument, Face Amount																						1,728,000
Fourth Note [Member] | Convertible Debt [Member] | Investor [Member]
Debt Instrument, Face Amount																						1,272,000
Fifth Note [Member] | Convertible Debt [Member]
Debt Instrument, Unamortized Discount, Total																						400,485
Fifth Note [Member] | Non-convertible Promissory Notes [Member]
Debt Agreement, Maximum Borrowing Capacity				$ 985,000																				$ 485,000
Debt Instrument, Interest Rate, Stated Percentage																								10.00%
Debt Agreement, Additional Borrowing Capacity				300,000		$ 200,000
Debt Issuance Costs, Net, Total				363,748
Proceeds from (Repayments of) Notes Payable, Total			$ (1,005,039)
Fifth Note [Member] | Non-convertible Promissory Notes [Member] | Subsequent Event [Member]
Proceeds from Issuance of Long-term Debt, Total	$ 860,000
Fifth Note [Member] | Non-convertible Promissory Notes [Member] | Non-related Party Investors [Member]
Debt Issuance Costs, Net, Total				297,325
Debt Instrument, Unamortized Discount, Total																						266,432
Fifth Note [Member] | Non-convertible Promissory Notes [Member] | Related Party [Member]
Proceeds from Issuance of Long-term Debt, Total					$ 125,000
Debt Issuance Costs, Net, Total				$ 66,423
Debt Instrument, Unamortized Discount, Total																						$ 59,521

Note 6 - Notes Payable - Summar

Note 6 - Notes Payable - Summarizes Notes Payable and Interest (Details) - USD ($)	Dec. 31, 2018	Aug. 10, 2018	Apr. 17, 2018	Dec. 31, 2017	Nov. 01, 2017	Jan. 18, 2017
Convertible Debt [Member]
Principal	$ 10,400,000			$ 6,025,000
Interest	1,287,084			295,830
Unamortized Discount	(193,024)
Principal, Net	10,206,976
Convertible Debt [Member] | Non-related Party Investors [Member]
Principal	1,978,000
Interest	126,529
Unamortized Discount	(193,024)
Principal, Net	1,784,976
Convertible Debt [Member] | Related Party [Member]
Principal	8,422,000			6,025,000
Interest	1,160,555			$ 295,830
Unamortized Discount
Principal, Net	$ 8,422,000
Convertible Debt [Member] | First Note [Member]
Interest Rate Initial	8.25%			8.25%		8.25%
Interest Rate Post-Maturity	12.00%			12.00%		12.00%
Principal	$ 5,000,000			$ 5,000,000
Interest
Convertible Debt [Member] | First Note [Member] | Non-related Party Investors [Member]
Principal
Interest
Convertible Debt [Member] | First Note [Member] | Related Party [Member]
Principal	5,000,000			5,000,000
Interest
Convertible Debt [Member] | Fifth Note [Member]
Unamortized Discount	$ (400,485)
Convertible Debt [Member] | Second Note [Member]
Interest Rate Initial	8.25%			8.25%	8.25%
Interest Rate Post-Maturity	12.00%			12.00%	12.00%
Principal	$ 1,900,000			$ 1,025,000
Interest
Convertible Debt [Member] | Second Note [Member] | Non-related Party Investors [Member]
Principal
Interest
Convertible Debt [Member] | Second Note [Member] | Related Party [Member]
Principal	1,900,000			1,025,000
Interest
Convertible Debt [Member] | Third Note [Member]
Interest Rate Initial	10.00%	10.00%
Interest Rate Post-Maturity	10.00%
Principal	$ 500,000
Interest
Convertible Debt [Member] | Third Note [Member] | Non-related Party Investors [Member]
Principal	250,000
Interest
Convertible Debt [Member] | Third Note [Member] | Related Party [Member]
Principal	250,000
Interest
Convertible Debt [Member] | Fourth Note [Member]
Interest Rate Initial	10.00%		10.00%
Interest Rate Post-Maturity	10.00%
Principal	$ 3,000,000
Interest
Convertible Debt [Member] | Fourth Note [Member] | Non-related Party Investors [Member]
Principal	1,728,000
Interest
Convertible Debt [Member] | Fourth Note [Member] | Related Party [Member]
Principal	1,272,000
Interest
Notes Payable, Other Payables [Member]
Principal	685,000
Interest	9,439
Unamortized Discount	(325,953)
Principal, Net	359,047
Notes Payable, Other Payables [Member] | Non-related Party Investors [Member]
Principal	560,000
Interest	7,275
Unamortized Discount	(266,432)
Principal, Net	293,568
Notes Payable, Other Payables [Member] | Related Party [Member]
Principal	125,000
Interest	2,164
Unamortized Discount	(59,521)
Principal, Net	$ 65,479
Notes Payable, Other Payables [Member] | Fifth Note [Member]
Interest Rate Initial	10.00%
Interest Rate Post-Maturity	10.00%
Principal	$ 685,000
Interest
Notes Payable, Other Payables [Member] | Fifth Note [Member] | Non-related Party Investors [Member]
Principal	560,000
Interest
Notes Payable, Other Payables [Member] | Fifth Note [Member] | Related Party [Member]
Principal	125,000
Interest

Note 7 - Commitments and Cont_3

Note 7 - Commitments and Contingencies (Details Textual) - USD ($)	Jul. 15, 2018	Dec. 31, 2018	Dec. 31, 2017
Operating Leases, Rent Expense, Net, Total		$ 89,643	$ 96,631
office Space Lease Arrangement [Member]
Lessee, Operating Lease, Term of Contract	5 years
Leases, Monthly Payment	$ 8,053
MD Anderson [Member]
Payments for Patent and Technology License Agreement Expenses		$ 55,000	$ 45,000

Note 7 - Commitments and Cont_4

Note 7 - Commitments and Contingencies - Future Minimum Lease Payments (Details)	Dec. 31, 2018USD ($)
2019	$ 103,737
2020	108,429
Thereafter	36,668
Total future minimum lease payments	$ 248,834

Note 8 - Stockholders' Defici_2

Note 8 - Stockholders' Deficit (Details Textual) - USD ($)	Oct. 01, 2017	Dec. 31, 2018	Dec. 31, 2017	Jun. 30, 2018	Jun. 08, 2018	Apr. 20, 2018	Nov. 30, 2012
Preferred Stock, Shares Authorized		2,534,766
Preferred Stock, Par or Stated Value Per Share		$ 0.001
Dividends Payable		$ 1,280,000	$ 1,280,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross	15,000	2,220,000	15,000
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price	$ 0.13	$ 1.75	$ 0.13
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period	10 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Aggregated Grant Date Fair Value		$ 2,694,567
Share Price		$ 1.67
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested, Number of Shares	3,750
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		776,350
Class of Warrant or Right, Exercise Price of Warrants or Rights		$ 1.75
Warrants and Rights Outstanding		$ 878,622
Amortization of Debt Discount (Premium)		111,537
Extinguishment of Debt, Gain (Loss), Net of Tax, Total		132,708
Convertible Debt [Member]
Debt Instrument, Unamortized Discount, Total		193,024
Fifth Note [Member] | Convertible Debt [Member]
Debt Instrument, Unamortized Discount, Total		400,485
Amortization of Debt Discount (Premium)		$ 66,269
Measurement Input, Expected Term [Member]
Warrants and Rights Outstanding, Measurement Input		5
Measurement Input, Expected Dividend Payment [Member]
Warrants and Rights Outstanding, Measurement Input		0
Measurement Input, Share Price [Member]
Warrants and Rights Outstanding, Measurement Input		1.67
Warrant Issued Under Fourth Note [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		91,350			12,000	79,350
Class of Warrant or Right, Exercise Price of Warrants or Rights		$ 1.75			$ 1.75	$ 1.75
Warrants and Rights Outstanding		$ 103,006
Debt Instrument, Unamortized Discount, Total		$ 74,532
Fifth Note [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		685,000
Class of Warrant or Right, Exercise Price of Warrants or Rights		$ 1.75
Warrants and Rights Outstanding, Term		5 years
Minimum [Member] | Measurement Input, Discount Rate [Member]
Warrants and Rights Outstanding, Measurement Input		0.028
Minimum [Member] | Measurement Input, Price Volatility [Member]
Warrants and Rights Outstanding, Measurement Input		0.84
Maximum [Member] | Measurement Input, Discount Rate [Member]
Warrants and Rights Outstanding, Measurement Input		0.0305
Maximum [Member] | Measurement Input, Price Volatility [Member]
Warrants and Rights Outstanding, Measurement Input		0.86
Restricted Stock [Member]
Allocated Share-based Compensation Expense, Total		$ 533,550	$ 570,536
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period		177,500	177,500
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number, Ending Balance		127,500
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Total		$ 264,451
Employee Stock Option [Member]
Allocated Share-based Compensation Expense, Total		404,635	$ 15,570
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Total		$ 2,321,072
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period		10 years
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		4 years
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Discount Rate	1.92%	2.77%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term	5 years 273 days	6 years 91 days
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate	79.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Payments	$ 0	$ 0
Share Price	$ 3.21
Stock Granted, Value, Share-based Compensation, Net of Forfeitures, Total	$ 46,711
Employee Stock Option [Member] | Minimum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate		84.50%
Employee Stock Option [Member] | Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate		84.70%
2012 Long Term Incentive Plan [Member]
Common Stock, Capital Shares Reserved for Future Issuance							789,745
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		14,745
2018 Stock Plan [Member]
Common Stock, Capital Shares Reserved for Future Issuance				3,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant		780,000
Series A Preferred Stock [Member]
Preferred Stock, Shares Authorized		416,666	416,666
Preferred Stock, Par or Stated Value Per Share		$ 0.001	$ 0.001
Preferred Stock, Shares Issued, Total		416,666	416,666
Preferred Stock, Dividend Rate, Percentage		8.00%
Preferred Stock, Dividend Rate, Per-Dollar-Amount		$ 4.80
Preferred Stock, Dividend Payable, Share Price		$ 24
Preferred Stock, Dividend Payable, Gross Proceeds from Common Shares		$ 50,000,000
Preferred Stock, Dividend Payable, Percentage of Issued and Outstanding Shares		50.10%
Convertible Preferred Stock, Conversion Price		$ 4.80
Preferred Stock, Shares Outstanding, Ending Balance		416,666	416,666
Series B Preferred Stock [Member]
Preferred Stock, Shares Authorized		2,118,100	2,118,100
Preferred Stock, Par or Stated Value Per Share		$ 0.001	$ 0.001
Preferred Stock, Shares Issued, Total		2,118,100	2,118,100
Preferred Stock, Dividend Rate, Per-Dollar-Amount		$ 6.61
Convertible Preferred Stock, Conversion Price		$ 6.61
Dividends Payable		$ 4,613,260	$ 3,333,260
Preferred Stock, Shares Outstanding, Ending Balance		2,118,100	2,118,100

Note 8 - Stockholders' Defici_3

Note 8 - Stockholders' Deficit - Stock Options (Details) - USD ($)	Oct. 01, 2017	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Outstanding, Number of Shares (in shares)		15,000
Outstanding, Weighted Average Exercise Price (in dollars per share)		$ 0.13
Outstanding, Weighted Average Remaining Life (Year)		9 years 160 days	9 years 273 days
Granted, Number of Shares (in shares)	15,000	2,220,000	15,000
Granted, Weighted Average Exercise Price (in dollars per share)	$ 0.13	$ 1.75	$ 0.13
Outstanding, Number of Shares (in shares)		2,235,000	15,000
Outstanding, Weighted Average Exercise Price (in dollars per share)		$ 1.74	$ 0.13
Outstanding, Aggregate Intrinsic Value		$ 23,100
Exercisable, Number of Shares (in shares)		7,500
Exercisable, Weighted Average Exercise Price (in dollars per share)		$ 0.13
Exercisable, Weighted Average Remaining Life (Year)		8 years 277 days
Exercisable, Aggregate Intrinsic Value		$ 11,550

Note 8 - Stockholders' Defici_4

Note 8 - Stockholders' Deficit - Warrants (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Warrant outstanding, shares (in shares)
Warrant outstanding, weighted average exercise price (in dollars per share)
Warrant outstanding, weighted average remaining contractual term (Year)	4 years 292 days
Warrant granted, shares (in shares)	776,350
Warrant granted, weighted average exercise price (in dollars per share)	$ 1.75
Warrant exercised, shares (in shares)
Warrant exercised, weighted average exercise price (in dollars per share)
Warrant canceled, shares (in shares)
Warrant canceled, weighted average exercise price (in dollars per share)
Warrant outstanding, shares (in shares)	776,350
Warrant outstanding, weighted average exercise price (in dollars per share)	$ 1.75
Warrant outstanding, aggregate intrinsic value
Warrant exercisable, shares (in shares)	776,350
Warrant exercisable, weighted average exercise price (in dollars per share)	$ 1.75
Warrant exercisable, weighted average remaining contractual term (Year)	4 years 292 days
Warrant exercisable, aggregate intrinsic value

Note 9 - Income Taxes (Details

Note 9 - Income Taxes (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability		$ 3,400
Income Tax Expense (Benefit), Total	$ 0	$ 0
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	21.00%	34.00%
Operating Loss Carryforwards, Increase	$ 5,000
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount	1,900
Domestic Tax Authority [Member]
Operating Loss Carryforwards, Total	$ 24,700

Note 9 - Income Taxes - Income

Note 9 - Income Taxes - Income Tax Reconciliation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017
Tax benefit at the U.S. federal statutory rate, amount	$ (1,956,137)	$ (2,543,412)
Tax benefit at the U.S. federal statutory rate, percent	(21.00%)	(34.00%)
Tax rate change, amount		$ 3,391,624
Tax rate change, percent		45.34%
Permanent differences, amount	$ 119,266	$ 8,908
Permanent differences, percent	1.28%	0.11%
Return to provision, amount	$ (94,219)	$ (92,256)
Return to provision, percent	(1.01%)	(1.23%)
Valuation allowance, amount	$ 1,931,090	$ (764,864)
Valuation allowance, percent	20.73%	(10.23%)
Effective income tax rate, amount	$ 0	$ 0
Effective income tax rate, percent

Note 9 - Income Taxes - Deferre

Note 9 - Income Taxes - Deferred Tax Assets and Liabilities (Details) - USD ($)	Dec. 31, 2018	Dec. 31, 2017
Assets related to:
Accounts payable and accrued liabilities	$ 1,224,599	$ 325,560
Net operating losses	6,240,595	5,192,813
Total deferred tax assets	7,465,194	5,518,373
Valuation allowance for deferred tax assets	(7,409,867)	(5,478,777)
Net deferred tax	55,327	39,596
Liabilities related to:
Accounts receivable and prepaid expenses	(27,976)	(665)
Depreciation and amortization of property and equipment and intangibles	(27,351)	(38,931)
Net deferred tax liabilities	(55,327)	(39,596)
Net deferred tax assets

Note 10 - Subsequent Events (De

Note 10 - Subsequent Events (Details Textual)	Mar. 12, 2019USD ($)	Feb. 26, 2019USD ($)	Feb. 05, 2019$ / sharesshares	Oct. 01, 2017$ / sharesshares	Jan. 31, 2019USD ($)	Dec. 31, 2018$ / sharesshares	Dec. 31, 2017$ / sharesshares	Mar. 20, 2019USD ($)	Feb. 28, 2019USD ($)$ / sharesshares	Feb. 19, 2019shares
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | shares				15,000		2,220,000	15,000
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares				$ 0.13		$ 1.75	$ 0.13
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period				10 years
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares						$ 1.75
Preferred Stock, Shares Authorized | shares						2,534,766
Common Stock, Shares Authorized | shares						100,000,000	100,000,000
Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period						10 years
Subsequent Event [Member]
Extinguishment of Deferred Compensation, Amount					$ 484,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross | shares			401,750
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ / shares			$ 1.75
Share-based Compensation Arrangement by Share-based Payment Award, Options, Number of Quarterly Installments			4
Preferred Stock, Shares Authorized | shares										0
Common Stock, Shares Authorized | shares										100,000,000
Letters of Credit Outstanding, Amount								$ 200,000
Subsequent Event [Member] | Non-employee Director [Member]
One-time Cash Compensation Paid for Services to Each Independent Director		$ 25,000
Subsequent Event [Member] | Chief Executive Officer [Member]
Salary and Wage, Excluding Cost of Good and Service Sold, Total	$ 60,000
Subsequent Event [Member] | Chief Financial Officer [Member]
Salary and Wage, Excluding Cost of Good and Service Sold, Total	70,000
Subsequent Event [Member] | Chief Operating Officer [Member]
Salary and Wage, Excluding Cost of Good and Service Sold, Total	30,000
Subsequent Event [Member] | Board of Directors Chairman [Member]
Salary and Wage, Excluding Cost of Good and Service Sold, Total	$ 60,000
Subsequent Event [Member] | Warrants in Connection with Non-convertible Promissory Notes [Member]
Warrants and Rights Outstanding, Term									5 years
Class of Warrant or Right, Exercise Price of Warrants or Rights | $ / shares									$ 1.75
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right | shares									1
Subsequent Event [Member] | Non-convertible Promissory Notes [Member]
Debt Instrument, Face Amount									$ 300,000
Debt Instrument, Interest Rate, Stated Percentage									10.00%
Subsequent Event [Member] | Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period			10 years