Syros Pharmaceuticals (SYRS) SC 13G/A Syros Pharmaceuticals / Avidity Partners Management ownership change

Exhibit A

JOINT FILING AGREEMENT

The undersigned agree that this Schedule 13G Amendment No. 4 dated February 14, 2025 relating to the Common Stock, $0.001 par value, of Syros Pharmaceuticals, Inc. shall be filed on behalf of the undersigned.

AVIDITY PARTNERS MANAGEMENT LP

By Avidity Partners Management (GP) LLC, its general partner

By: /s/ Michael Gregory

Title: Managing Member

AVIDITY PARTNERS MANAGEMENT (GP) LLC

By: /s/ Michael Gregory

Title: Managing Member

AVIDITY CAPITAL PARTNERS FUND (GP) LP

By Avidity Capital Partners (GP) LLC, its general partner

By: /s/ Michael Gregory

Title: Managing Member

AVIDITY CAPITAL PARTNERS (GP) LLC

By: /s/ Michael Gregory

Title: Managing Member

AVIDITY MASTER FUND LP

By Avidity Capital Partners Fund (GP) LP, its general partner

By: Avidity Capital Partners (GP) LLC, its general partner

By: /s/ Michael Gregory

Title: Managing Member

AVIDITY PRIVATE MASTER FUND I LP

By Avidity Capital Partners Fund (GP) LP, its general partner

By: Avidity Capital Partners (GP) LLC, its general partner

By: /s/ Michael Gregory

Title: Managing Member

DAVID WITZKE

By: /s/ David Witzke

MICHAEL GREGORY

By: /s/ Michael Gregory