Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” in this Registration Statement (Form S-3) and related Prospectus of Epizyme, Inc. for the registration of its debt securities, common stock, preferred stock, units and warrants and to the incorporation by reference therein of our reports dated February 23, 2021, with respect to the consolidated financial statements of Epizyme, Inc., and the effectiveness of internal control over financial reporting of Epizyme, Inc., included in its Annual Report (Form 10-K) for the year ended December 31, 2020, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Boston, Massachusetts
May 6, 2021
