EPIZYME, INC.
400 Technology Square, 4th Floor
Cambridge, MA 02139
May 11, 2021
VIA EDGAR
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
| Re: | Epizyme, Inc. |
Registration Statement on Form S-3
File No. 333-255806
Request for Acceleration
Ladies and Gentlemen:
Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended, Epizyme, Inc. (the “Registrant”) hereby requests acceleration of the effective date of its Registration Statement on Form S-3 (File No. 333-255806), so that it may become effective at 4:00 p.m. Eastern time on May 13, 2021, or as soon thereafter as practicable, or at such later time as the Registrant or its counsel may orally request via telephone call to the staff.
| Very truly yours, | ||
| EPIZYME, INC. | ||
| By: | /s/ Paolo Tombesi | |
| Name: | Paolo Tombesi | |
| Title: | Chief Financial Officer | |
| cc: | Stuart M. Falber |
Molly W. Fox
Wilmer Cutler Pickering Hale and Dorr LLP
