Synaptogenix (SNPX) 10-Q 15 May 24 2024 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2024	May 13, 2024
Document and Entity Information
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2024
Document Transition Report	false
Entity File Number	001-40458
Entity Registrant Name	Synaptogenix, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	46-1585656
Entity Address, Address Line One	1185 Avenue of the Americas
Entity Address, Address Line Two	3rd Floor
Entity Address, City or Town	New York
Entity Address, State or Province	NY
Entity Address, Postal Zip Code	10036
City Area Code	973
Local Phone Number	242-0005
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	SNPX
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		1,233,230
Entity Central Index Key	0001571934
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2024
Document Fiscal Period Focus	Q1
Amendment Flag	false

Condensed Balance Sheets

Condensed Balance Sheets - USD ($)		Mar. 31, 2024	Dec. 31, 2023
CURRENT ASSETS
Cash and cash equivalents		$ 26,329,957	$ 28,661,498
Prepaid Clinical trial expenses			375,085
Available for sale debt security		1,937,800	1,438,500
Prepaid expenses and other current assets		560,583	57,677
TOTAL CURRENT ASSETS		28,828,340	30,532,760
Equity method investment		553,802	562,402
Fixed assets, net of accumulated depreciation		17,106	18,505
TOTAL ASSETS		29,399,248	31,113,667
CURRENT LIABILITIES
Accounts payable		238,905	444,633
Accrued expenses		45,692	435,891
Accrued Series B Convertible Preferred payments payable		6,015,115	3,395,945
TOTAL CURRENT LIABILITIES		6,299,712	4,276,469
Warrant liability		82,000	140,000
Derivative liability		141,000	1,113,000
TOTAL LIABILITIES		6,522,712	5,529,469
Commitments and contingencies
Series B Convertible redeemable preferred stock, $.0001 par value and $1,000 face value, 1,000,000 shares authorized; 3,000 and 6,000 shares issued and outstanding at March 31, 2024 and December 31, 2023, respectively.Liquidation preference of $3,000,000 plus dividends accrued at 7% per annum of $839,228 as of March 31, 2024.		823,555	1,236,940
STOCKHOLDERS' EQUITY
Common stock - 150,000,000 shares authorized, $0.0001 par value;1,085,237 shares issued and outstanding as of March 31, 2024 and963,489 shares issued and outstanding as of December 31, 2023.	[1]	109	96
Additional paid-in capital		56,088,576	57,957,008
Accumulated other comprehensive income		202	902
Accumulated deficit		(34,035,906)	(33,610,748)
TOTAL STOCKHOLDERS' EQUITY		22,052,981	24,347,258
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY		$ 29,399,248	$ 31,113,667
[1]Adjusted to reflect the impact of the 1

Condensed Balance Sheets (Paren

Condensed Balance Sheets (Parenthetical)	3 Months Ended	12 Months Ended
	Mar. 31, 2024 USD ($) $ / shares shares	Dec. 31, 2023 $ / shares shares
Series B Convertible redeemable preferred stock, par value (in dollars per share) | $ / shares	$ 0.0001	$ 0.0001
Series B Convertible redeemable preferred stock, face value (in dollars per share) | $ / shares	$ 1,000	$ 1,000
Series B Convertible redeemable preferred stock, Shares authorized	1,000,000	1,000,000
Series B Convertible redeemable preferred stock, Shares issued	3,000	6,000
Series B Convertible redeemable preferred stock, Shares outstanding	3,000	6,000
Series B Convertible redeemable preferred stock, Liquidation preference value | $	$ 3,000,000
Series B Convertible redeemable preferred stock, Liquidation preference, percentage of accrued dividends	7%
Series B Convertible redeemable preferred stock, Liquidation preference, amount of accrued dividends | $	$ 839,228
Common stock, shares authorized	150,000,000	150,000,000
Common stock, par value (in dollars per share) | $ / shares	$ 0.0001	$ 0.0001
Common stock, shares issued	1,085,237	963,489
Common stock, shares outstanding	1,085,237	963,489

Condensed Statements of Compreh

Condensed Statements of Comprehensive Loss - USD ($)		3 Months Ended
		Mar. 31, 2024	Mar. 31, 2023
OPERATING EXPENSES:
Research and development		$ 609,249	$ 877,717
General and administrative		1,082,245	2,044,224
TOTAL OPERATING EXPENSES		1,691,494	2,921,941
OTHER INCOME:
Interest income		463,395	396,357
Share of net loss in equity investment		(8,600)
Change in fair value of warrant liability		58,000	588,000
Change in fair value of derivative liability		972,000	225,800
TOTAL OTHER INCOME		1,484,795	1,210,157
Net loss before income taxes		(206,699)	(1,711,784)
Net loss		(206,699)	(1,711,784)
Preferred Stock dividends		218,459	266,074
Net Loss attributable to common stockholders		(425,158)	(1,977,858)
Change in fair value of available for sale debt security		(700)
Net comprehensive loss		$ (425,858)	$ (1,977,858)
PER SHARE DATA:
Basic loss per common share (in dollars per share)	[1]	$ (0.41)	$ (6.59)
Diluted loss per common share (in dollars per share)	[1]	$ (0.41)	$ (6.59)
Basic weighted average common shares outstanding (in shares)	[1]	1,036,700	300,100
Diluted weighted average common shares outstanding (in shares)	[1]	1,036,700	300,100
[1]Adjusted to reflect the impact of the 1

Condensed Statements of Compr_2

Condensed Statements of Comprehensive Loss (Parenthetical)	Apr. 04, 2024
Subsequent Event
Reverse Stock Split, conversion ratio	0.04

Condensed Statements of Changes

Condensed Statements of Changes in Stockholders' Equity - USD ($)	Preferred Stock	Common Stock	Additional Paid-In Capital	Accumulated Deficit	Accumulated Other Comprehensive Income (Loss)	Total
Balance, Beginning at Dec. 31, 2022		$ 29	$ 52,524,461	$ (19,831,517)		$ 32,692,973
Balance, Beginning (in shares) at Dec. 31, 2022		290,681
Beginning balance at Dec. 31, 2022	$ 2,721,723
Beginning balance (in shares) at Dec. 31, 2022	15,000
Stock based compensation			644,781			644,781
Issuance of common stock for consulting fees		$ 3	104,497			104,500
Issuance of common stock for consulting fees (in shares)		3,713
Preferred dividends				(266,074)		(266,074)
Net Income (Loss)				(1,711,784)		(1,711,784)
Balance, Ending at Mar. 31, 2023		$ 32	53,273,739	(21,809,375)		31,464,396
Balance, Ending (in shares) at Mar. 31, 2023		294,394
Ending balance at Mar. 31, 2023	$ 2,721,723
Ending balance (in shares) at Mar. 31, 2023	15,000
Balance, Beginning at Dec. 31, 2023		$ 96	57,957,008	(33,610,748)	$ 902	24,347,258
Balance, Beginning (in shares) at Dec. 31, 2023		963,489
Beginning balance at Dec. 31, 2023	$ 1,236,940					$ 1,236,940
Beginning balance (in shares) at Dec. 31, 2023	6,000					6,000
Stock based compensation	$ 0	$ 0	14,407	0	0	$ 14,407
Issuance of common stock for consulting fees		$ 2	104,498			104,500
Issuance of common stock for consulting fees (in shares)		15,622
Preferred dividends						(218,459)
Accrued preferred stock dividends	87,500			(87,500)		(87,500)
Deemed dividends on preferred stock	130,959			(130,959)		(130,959)
Preferred stock redemptions and conversions	$ (468,330)	$ 11	468,319			468,330
Preferred stock redemptions and conversions (in shares)	(1,000)	106,126
Accrual of preferred stock and dividend redemption	$ (2,619,170)
Accrual of preferred stock and dividend redemption (in shares)	(2,000)
Preferred stock accretion	$ 2,455,656		(2,455,656)			(2,455,656)
Comprehensive income					(700)	(700)
Net Income (Loss)				(206,699)		(206,699)
Balance, Ending at Mar. 31, 2024		$ 109	$ 56,088,576	$ (34,035,906)	$ 202	22,052,981
Balance, Ending (in shares) at Mar. 31, 2024		1,085,237
Ending balance at Mar. 31, 2024	$ 823,555					$ 823,555
Ending balance (in shares) at Mar. 31, 2024	3,000					3,000

Condensed Statements of Chang_2

Condensed Statements of Changes in Stockholders' Equity (Parenthetical)	Apr. 04, 2024
Subsequent Event
Reverse Stock Split, conversion ratio	0.04

Condensed Statements of Cash Fl

Condensed Statements of Cash Flows - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
CASH FLOW USED IN OPERATING ACTIVITIES
Net loss	$ (206,699)	$ (1,711,784)
Adjustments to reconcile net loss to net cash used by operating activities
Stock based compensation	14,407	644,781
Change in fair value of warrant liability	(58,000)	(588,000)
Change in fair value of derivative liability	(972,000)	(225,800)
Share of net loss in equity investment	8,600
Consulting services paid by issuance of common stock	104,500	104,500
Depreciation expense	1,399	1,690
Change in assets and liabilities:
(Increase) decrease in prepaid expenses and other current assets	(127,821)	380,875
Decrease in accounts payable	(205,728)	(304,305)
Decrease (increase) in accrued expenses	(390,199)	2,231
Total adjustments	(1,624,842)	15,972
Net Cash Used in Operating Activities	(1,831,541)	(1,695,812)
CASH FLOWS USED IN INVESTING ACTIVITIES
Purchase of available for sale debt security	(500,000)
Purchase of fixed assets		(2,038)
Net Cash Used in Investing Activities	(500,000)	(2,038)
NET DECREASE IN CASH AND EQUIVALENTS	(2,331,541)	(1,697,850)
CASH AND EQUIVALENTS AT BEGINNING OF PERIOD	28,661,498	37,478,480
CASH AND EQUIVALENTS AT END OF PERIOD	26,329,957	35,780,630
DISCLOSURES OF NON-CASH INVESTING AND FINANCING ACTIVITIES:
Issuance of Common Stock for Series B Convertible Preferred Stock installment conversions	468,330
Accretion of Series B Convertible Preferred Stock to redemption value	2,455,656
Accrual of Series B Convertible Preferred Stock and Dividend Redemption	2,619,170	$ 266,074
Change in fair value of available for sale debt security	$ (700)

Organization, Business, Risks a

Organization, Business, Risks and Uncertainties:	3 Months Ended
	Mar. 31, 2024
Organization, Business, Risks and Uncertainties:
Organization, Business, Risks and Uncertainties:	Note 1 – Organization, Business, Risks and Uncertainties: Organization and Business On May 17, 2020, Neurotrope, Inc. (“Neurotrope” or “the Parent”) announced plans for the complete legal and structural separation of its wholly owned subsidiary, Neurotrope Bioscience, Inc., from Neurotrope (the “Spin-Off”). Under the Separation and Distribution Agreement, Neurotrope planned to distribute all of its equity interest in this wholly owned subsidiary to Neurotrope’s stockholders. Following the Spin-Off, Neurotrope does not own any equity interest in the Company, and the Company operates independently from Neurotrope. On December 7, 2020, the Company became an independent company, Synaptogenix, Inc., a Delaware corporation (formerly known as Neurotrope Bioscience, Inc.) (the “Company” or “Synaptogenix”) when the Company filed an amended and restated certificate of incorporation which, among other things, changed its name to Synaptogenix, Inc. The Company’s shares of common stock, par value $0.0001 per share (the “Common Stock”), are listed on The Nasdaq Capital Market under the symbol “SNPX.” On April 24, 2023, the Company received a written notice from the Listing Qualifications Department of the Nasdaq Stock Market LLC (“Nasdaq”) notifying the Company that for the preceding 30 consecutive business days, the Common Stock did not maintain a minimum closing bid price of $1.00 per share as required by Nasdaq Listing Rule 5550(a)(2) (the “Minimum Bid Price Requirement”). In accordance with Nasdaq Listing Rule 5810(c)(3)(A), the Company received an initial grace period of 180 calendar days, or until October 23, 2023 (the “Initial Compliance Period”), to regain compliance with the Minimum Bid Price Requirement. On October 24, 2023, the Company received a second written notice from Nasdaq, notifying the Company that it had not regained compliance with the Minimum Bid Price Requirement during the Initial Compliance Period and granting the Company an additional grace period of 180 calendar days, or until April 22, 2024, to regain compliance. On April 4, 2024, the Company effected a one On April 22, 2024, Nasdaq informed the Company that it had retained compliance with the Minimum Bid Price Requirement and that the matter was closed. Reverse Stock Split On April 4, 2024, the Company effected the Reverse Stock Split. All share and per share information in this quarterly report have been retroactively adjusted to reflect the Reverse Stock Split. Liquidity Uncertainties As of March 31, 2024, the Company had approximately $26.3 million in cash and cash equivalents as compared to $28.7 million at December 31, 2023. The Company expects that its current cash and cash equivalents, approximately $25.9 million as of the date of this Quarterly Report on Form 10-Q, will be sufficient to support its projected operating requirements and financial commitments for at least the next 12 months from the date of this Quarterly Report. The operating requirements include the current development plans for Bryostatin-1, the Company’s novel drug candidate targeting the activation of Protein Kinase C Epsilon and other development projects. The financial commitments include the potential redemption of the Series B Convertible Preferred Stock for cash. The Company expects to need additional capital in order to initiate and pursue potential additional development projects, including the continuing development beyond the ongoing Phase 2 trial of Bryostatin-1. Any additional equity financing, if available, may not be on favorable terms and would likely be significantly dilutive to the Company’s current stockholders, and debt financing, if available, may involve restrictive covenants. If the Company is able to access funds through collaborative or licensing arrangements, it may be required to relinquish rights to some of its technologies or product candidates that the Company would otherwise seek to develop or commercialize on its own, on terms that are not favorable to the Company. The Company’s ability to access capital when needed is not assured and, if not achieved on a timely basis, will likely have a materially adverse effect on its business, financial condition and results of operations. Other Risks and Uncertainties The Company operates in an industry that is subject to rapid technological change, intense competition, and significant government regulation. The Company’s operations are subject to significant risk and uncertainties including financial, operational, technological and regulatory. Such factors include, but are not necessarily limited to, the results of clinical testing and trial activities, the ability to obtain regulatory approval, the limited supply of raw materials, the ability to obtain favorable licensing, manufacturing or other agreements, including risk associated with the Company’s Cognitive Research Enterprises, Inc. (formerly known as the Blanchette Rockefeller Neurosciences Institute, or BRNI) (“CRE”) licensing agreement, and the ability to raise capital to achieve strategic objectives. CRE has entered into a material transfer agreement with the National Cancer Institute of the National Institutes of Health (“NCI”), pursuant to which the NCI has agreed to supply bryostatin required for the Company’s pre-clinical research and clinical trials. This agreement does not provide for a sufficient amount of bryostatin to support the completion of all of the clinical trials that the Company is required to conduct in order to seek U.S. Food and Drug Administration (“FDA”) approval. Therefore, CRE or the Company would have to enter into one or more subsequent agreements with the NCI for the supply of additional amounts of bryostatin. If CRE or the Company were unable to secure such additional agreements, or if the NCI otherwise discontinues the supply, the Company would have to either secure another source of bryostatin or discontinue its efforts to develop and commercialize Bryostatin-1 for the treatment of AD. In June 2020, the Company entered into a supply agreement (the “Supply Agreement”) with BryoLogyx Inc. (“BryoLogyx”), pursuant to which BryoLogyx agreed to be the Company’s exclusive supplier of synthetic bryostatin. Pursuant to the terms of the Supply Agreement, the Company received its initial order of one gram of synthetic bryostatin. See Note 3.

Summary of Significant Accounti

Summary of Significant Accounting Policies:	3 Months Ended
	Mar. 31, 2024
Summary of Significant Accounting Policies:
Summary of Significant Accounting Policies:	Note 2 – Summary of Significant Accounting Policies: Basis of Presentation: The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial reporting and with the instructions to Form 10-Q and Article 10 of Regulation S-X. In the opinion of management, the unaudited condensed financial statements included herein contain all adjustments necessary to present fairly the Company’s financial position and the results of its operations and cash flows for the interim periods presented. Such adjustments are of a normal recurring nature. The results of operations for the three months ended March 31, 2024 may not be indicative of results for the full year. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and the notes to those statements for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC on April 1, 2024. The Company is an emerging growth company as the term is used in The Jumpstart Our Business Startups Act, enacted on April 5, 2012, and has elected to comply with certain reduced public company reporting requirements, however, the Company may adopt accounting standards based on the effective dates for public entities. Use of Estimates: The preparation of financial statements in conformity with GAAP requires management to make significant estimates that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Management evaluates its estimates on an ongoing basis using historical experience and other factors, including the general economic environment and actions it may take in the future. The Company adjusts such estimates when facts and circumstances dictate. However, these estimates may involve significant uncertainties and judgments and cannot be determined with precision. In addition, these estimates are based on management’s best judgment at a point in time and as such these estimates may ultimately differ from actual results. Comprehensive Income (Loss) The Company follows The Company follows Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 220 in reporting comprehensive income (loss). Comprehensive income (loss) is a more inclusive financial reporting methodology that includes disclosure of certain financial information that historically has not been recognized in the calculation of net income (loss). Since the Company has items of other comprehensive income (loss), comprehensive income (loss) has been reflected in the Company’s financial statements. Net Earnings or Loss per Share: Net earnings or loss per share is computed by dividing net income or loss by the weighted-average number of shares of Common Stock outstanding during the period, excluding shares subject to redemption or forfeiture. The Company presents basic and diluted net earnings or loss per share. Diluted net earnings or loss per share reflect the actual weighted average of shares of Common Stock issued and outstanding during the period, adjusted for potentially dilutive securities outstanding. Potentially dilutive securities are excluded from the computation of the diluted net earnings or loss per share if their inclusion would be anti-dilutive. As all potentially dilutive securities are anti-dilutive as of March 31, 2024 and 2023, diluted net loss per share is the same as basic net loss per share for the three months ended March 31, 2024 and 2023. The weighted average dilutive securities that have been excluded from the calculation of diluted net loss per share for the three months ended March 31, 2024 and 2023 respectively, because to do so would be anti-dilutive (in Common Stock equivalents), are as follows: ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ March 31, ​ 2024 2023 Common Stock Options 29,674 29,674 Convertible Preferred Stock ​ 46,530 ​ — Common Stock Warrants 287,436 287,197 Total 363,640 316,871 ​ Cash and Cash Equivalents and Concentration of Credit Risk: The Company considers all highly liquid cash investments with an original maturity of three months or less when purchased to be cash equivalents. At March 31, 2024, the Company’s cash balances that exceed the current insured amounts under the Federal Deposit Insurance Corporation (“FDIC”) were approximately $0.4 million. In addition, approximately $25.9 million included in cash and cash equivalents were invested in a money market fund and in U.S. treasury bills, which is not insured under the FDIC. Investment in Debt Securities The Company’s convertible note receivable was determined to be an available-for-sale debt security under ASC 320, Investments, Fair Value of Financial Instruments: The carrying amounts reflected in the balance sheets for prepaid expenses and payables approximate fair value due to the short maturities of these instruments. The carrying amounts for available for sale debt security, warrant liability and derivative liability approximate fair value based on level 3 of the fair value hierarchy. Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy: Level 1 — Quoted prices in active markets for identical assets or liabilities. Level 2 — Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable markets. Level 3 — Unobservable inputs which are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques. Fixed Assets and Leases: The Company has two leases, both of which have a term of one year during the respective reporting periods. The Company has deemed the leases immaterial and has not recorded it as an obligation on the balance sheet nor a right-of-use asset. The total future expense relating to these leases is approximately $40,000 per year. Fixed assets are stated at cost less accumulated depreciation. Depreciation is computed on a straight line basis over the estimated useful life of the asset, which is deemed to be between three Research and Development Costs: All research and development costs, including costs to maintain or expand the Company’s patent portfolio licensed from CRE are expensed when incurred. Non-refundable advance payments for research and development are capitalized because the right to receive those services represents an economic benefit. Such capitalized advances will be expensed when the services occur and the economic benefit is realized. There were no capitalized research and development services, other than non-refundable advance payments as mentioned below for The Cleveland Clinic Foundation (“Cleveland Clinic”), at March 31, 2024 and December 31, 2023. Income Taxes: The Company accounts for income taxes using the asset and liability approach which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and amounts reportable for income tax purposes under the “Separate return method.” Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized. The Company applies the provisions for accounting for uncertainty in income taxes recognized in an enterprise’s financial statements and prescribes a recognition threshold and measurement process for financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. The Company has determined that there are no significant uncertain tax positions requiring recognition in the accompanying financial statements. The tax period that is subject to examination by major tax jurisdictions is generally three years from the date of filing. The Company had federal operating loss carryforwards for income tax purposes of approximately $95.9 million for the period from October 31, 2012 (inception) through March 31, 2024. The net operating loss carryforwards and other deferred tax assets resulted in Federal and state deferred tax assets of approximately $30.6 million at March 31, 2024. Income tax effects of share-based payments are recognized in the financial statements for those awards that will normally result in tax deductions under existing tax law. However, the deferred tax asset is offset by a full valuation allowance. The Company may be subject to significant U.S. federal income tax-related liabilities with respect to the Spin-Off if there is a determination that the Spin-Off is taxable for U.S. federal income tax purposes. In connection with the Spin-Off, the Company believes that, among other things, the Spin-Off should qualify as a tax-free transaction for U.S. federal income tax purposes under Section 355 and Section 368(a)(1)(D) of the Internal Revenue Code of 1986 (the “Code”). If the conclusions of the tax opinions are not correct, or if the Spin-Off is otherwise ultimately determined to be a taxable transaction, the Company would be liable for U.S. federal income tax related liabilities. Pursuant to the Separation and Distribution Agreement and the Tax Matters Agreement, Neurotrope agreed to indemnify Synaptogenix for certain liabilities, and Synaptogenix agreed to indemnify Neurotrope for certain liabilities, in each case for uncapped amounts. Indemnities that Synaptogenix may be required to provide Neurotrope are not subject to any cap, may be significant and could negatively impact Synaptogenix’s business, particularly with respect to indemnities provided in the Tax Matters Agreement. Third parties could also seek to hold Synaptogenix responsible for any of the liabilities that Neurotrope has agreed to retain. Further, the indemnity from Neurotrope may not be sufficient to protect Synaptogenix against the full amount of such liabilities, and Neurotrope may not be able to fully satisfy its indemnification obligations. Moreover, even if Synaptogenix ultimately succeeds in recovering from Neurotrope any amounts for which Synaptogenix is held liable, Synaptogenix may be temporarily required to bear these losses. At December 31, 2023 and as of the date of financial statement issuance date, the Company does not have any indemnification liabilities. Under Section 382 of the Code, as amended, changes in the Company’s ownership may limit the amount of its net operating loss carryforwards that could be utilized annually to offset future taxable income, if any. This limitation would generally apply in the event of a cumulative change in ownership of the Company of more than 50% within a three-year period. In addition, the significant historical operating losses incurred by the Company may limit the amount of its net operating loss carryforwards that could be utilized annually to offset future taxable income, if any. The Company believes that operating loss carryforwards may be limited under Section 382 limitations although Section 382 studies have not been conducted to determine the actual limitations. The Company has concluded that there are no significant uncertain tax positions requiring recognition in the accompanying financial statements. The tax period that is subject to examination by major tax jurisdictions is generally three years from the date of filing. Recently Issued Accounting Pronouncements Adopted and Not Yet Adopted: As of March 31, 2024 and for the 3 months then ended, there were no recently issued accounting standards adopted or not yet adopted which would have a material effect on the Company’s financial statements.

Collaborative Agreements and Co

Collaborative Agreements and Commitments:	3 Months Ended
	Mar. 31, 2024
Collaborative Agreements and Commitments:
Collaborative Agreements and Commitments:	Note 3– Collaborative Agreements and Commitments: Stanford License Agreements On May 12, 2014, the Company entered into a license agreement (the “Stanford Agreement”) with The Board of Trustees of The Leland Stanford Junior University (“Stanford”), pursuant to which Stanford has granted to the Company a revenue-bearing, world-wide right and exclusive license, with the right to grant sublicenses (on certain conditions), under certain patent rights and related technology for the use of bryostatin structural derivatives, known as “bryologs,” for use in the treatment of central nervous system disorders, lysosomal storage diseases, stroke, cardio protection and traumatic brain injury, for the life of the licensed patents. The Company is required to use commercially reasonable efforts to develop, manufacture and sell products (“Licensed Products”) in the Licensed Field of Use (as defined in the Stanford Agreement) during the term of the licensing agreement which expires upon the termination of the last valid claim of any licensed patent under this agreement. In addition, the Company must meet specific product development milestones, and upon meeting such milestones, make specific milestone payments to Stanford. The Company must also pay Stanford royalties of 3% of net sales, if any, of Licensed Products (as defined in the Stanford Agreement) and milestone payments of up to $3.7 million dependent upon stage of product development. As of March 31, 2024, no royalties nor milestone payments have been required. On January 19, 2017, the Company entered into a second license agreement with Stanford, pursuant to which Stanford has granted to the Company a revenue-bearing, world-wide right and exclusive license, with the right to grant sublicenses (on certain conditions), under certain patent rights and related technology for the use of “Bryostatin Compounds and Methods of Preparing the Same,” or synthesized bryostatin, for use in the treatment of neurological diseases, cognitive dysfunction and psychiatric disorders, for the life of the licensed patents. The Company paid Stanford $70,000 upon executing the license and is obligated to pay an additional $10,000 annually as a license maintenance fee. In addition, based upon certain milestones that include product development and commercialization, the Company will be obligated to pay up to an additional $2.1 million and between 1.5% and 4.5% royalty payments on certain revenues generated by the Company relating to the licensed technology. On November 9, 2021, the Company revised the existing licensing agreement with Stanford. The revisions extended all the required future product development and commercialization milestones. The Company is currently in full compliance with the revised agreement and is moving forward on its commitments. As of March 31, 2024, no royalties nor milestone payments have been earned or made. The Company has advanced the development of synthetic bryostatin by demonstrating the equivalence of the synthetic to the natural bryostatin product. The estimated cost to initiate and produce sufficient quantities of the synthetic bryostatin drug product is approximately $1.5 million. The Company is evaluating production alternatives at this time. Mt. Sinai License Agreement On July 14, 2014, the Company entered into an Exclusive License Agreement (the “Mount Sinai Agreement”) with the Icahn School of Medicine at Mount Sinai (“Mount Sinai”). Pursuant to the Mount Sinai Agreement, Mount Sinai granted the Company (a) a revenue-bearing, world-wide right and exclusive license, with the right to grant sublicenses (on certain conditions), under Mount Sinai’s interest in certain joint patents held by the Company and Mount Sinai (the “Joint Patents”) as well as in certain results and data (the “Data Package”) and (b) a non-exclusive license, with the right to grant sublicenses on certain conditions, to certain technical information, both relating to the diagnostic, prophylactic or therapeutic use for treating diseases or disorders in humans relying on activation of Protein Kinase C Epsilon (“PKC ε”), which includes Niemann-Pick Disease (the “Mount Sinai Field of Use”). The Mount Sinai Agreement allows the Company to research, discover, develop, make, have made, use, have used, import, lease, sell, have sold and offer certain products, processes or methods that are covered by valid claims of Mount Sinai’s interest in the Joint Patents or an Orphan Drug Designation Application covering the Data Package (“Mount Sinai Licensed Products”) in the Mount Sinai Field of Use (as such terms are defined in the Mount Sinai Agreement). The Company is required to pay Mt. Sinai milestone payments of $2.0 million upon approval of a new drug application (“NDA”) in the United States and an additional $1.5 million for an NDA approval in the European Union or Japan. In addition, the Company is required to pay Mt. Sinai royalties on net sales of licensed product of 2.0% for up to $250 million of net sales and 3.0% of net sales over $250 million. Since inception, the Company has paid Mt. Sinai approximately $200,000 consisting of licensing fees of $125,000 plus development costs and patent fees of approximately $75,000. As of March 31, 2024, no royalties nor milestone payments have been required. Agreements with BryoLogyx On June 9, 2020, the Company entered into a supply agreement (the “Supply Agreement”) with BryoLogyx Inc. (“BryoLogyx”), pursuant to which BryoLogyx agreed to serve as the Company’s exclusive supplier of synthetic bryostatin. Pursuant to the terms of the Supply Agreement, the Company placed an initial order and subsequently received one gram of current good manufacturing practice (“cGMP”) synthetic bryostatin as an active pharmaceutical ingredient to be used in a drug product (“API”). The Company may place additional orders for API beyond the initial order by making a written request to BryoLogyx no later than six months prior to the requested delivery date. The Company is not currently using synthetic bryostatin for its current Phase 2 clinical trial and will determine when to incorporate the synthetic into the clinical trial process. In connection with the Supply Agreement, on June 9, 2020, the Company entered into a transfer agreement (the “Transfer Agreement”) with BryoLogyx. Pursuant to the terms of the Transfer Agreement, the Company agreed to assign and transfer to BryoLogyx all of the Company’s right, title and interest in and to that certain Cooperative Research and Development Agreement, dated as of January 29, 2019 (the “CRADA”), by and between the Company and the U.S. Department of Health and Human Services, as represented by the NCI, under which Bryostatin-1’s ability to modulate CD22 in patients with relapsed/refractory CD22+ disease has been evaluated to date. Pursuant to guidance provided by NCI, the Company CRADA has been cancelled and BryoLogyx has initiated a request for a new CRADA in its name. BryoLogyx will be filing its own investigational new drug application (“IND”) for CD22 with the FDA. As consideration for the transfer of rights to the CRADA, BryoLogyx has agreed to pay to the Company 2% of the gross revenue received in connection with the sale of bryostatin products, up to an aggregate payment amount of $1 million. No such revenues have been earned as of March 31, 2024. Nemours Agreement On September 5, 2018, the Company announced a collaboration with Nemours A.I. DuPont Hospital (“Nemours”), a premier U.S. children’s hospital, to initiate a clinical trial in children with Fragile X syndrome, a genetic disorder. In addition to the primary objective of safety and tolerability, measurements will be made of working memory, language and other functional aspects such as anxiety, repetitive behavior, executive functioning, and social behavior. On August 5, 2021, the Company announced its memorandum of understanding with Nemours to initiate a clinical trial using Bryostatin-1, under Orphan Drug Status, to treat Fragile X. The Company intends to provide the Bryostatin-1 and obtain the IND, and Nemours intends to provide the clinical site and attendant support for the trial. The Company and Nemours, jointly, will develop the trial protocol. The Company estimates its total trial and IND cost to be approximately $2.0 million. As of March 31, 2024, the Company has incurred cumulative expenses associated with this agreement of approximately $100,000. The Company has filed an IND with the FDA. The FDA has placed the development of the IND on clinical hold pending completion of further analytics relating to drug pharmacokinetics and pharmacodynamics. The Company is currently evaluating its plans to advance Fragile X development. Cleveland Clinic On February 23, 2022, the Company announced its collaboration with Cleveland Clinic to pursue possible treatments for Multiple Sclerosis (“MS”), and on July 19, 2023, the Company announced that it had entered into an agreement with Cleveland Clinic to conduct a Phase 1 trial of Bryostatin-1 in MS. Cleveland Clinic will manage the clinical trial’s implementation, including an IND submission to the FDA and patient enrollment. The total estimated costs associated with this collaboration are approximately $2.0 million. As of March 31, 2024, the Company has paid Cleveland Clinic approximately $375,000 which was expensed during this current quarter. Strategic Investment in Debt and Equity Securities of Cannasoul On October 31, 2023, the Company entered into a share purchase agreement (the “Purchase Agreement”) with Cannasoul Analytics Ltd. (“Cannasoul”), pursuant to which the Company agreed to purchase from Cannasoul (i) 12,737 shares of Cannasoul’s Series A preferred shares (the “Preferred Shares”), representing 5% of Cannasoul’s issued and outstanding share capital, at a price of $44.1550 per Preferred Share for $562,402 and (ii) a convertible preferred note in an aggregate amount of up to $1,437,598 (the “Initial Convertible Note”) convertible into 32,648 Preferred Shares. The Preferred Shares are convertible (i) any time after the date of issuance at the Company’s option and (ii) automatically upon the earlier of a payment default, the consummation of Cannasoul’s IPO, or the majority consent of the majority holders of the Preferred Shares. Additionally, the Company agreed to purchase up to four additional convertible preferred notes in a total amount of up to approximately $2,000,000 (or approximately $500,000 per convertible preferred note), subject to Cannasoul achieving certain revenue and expense goals (the “Milestones”) over the next four quarters (the “Milestone Convertible Notes” and, together with the Initial Convertible Note, the “Cannasoul Convertible Notes”) as set forth in the Purchase Agreement. The Company’s purchase of the Preferred Shares, the Initial Convertible Notes and the Milestone Convertible Notes is herein referred to as the “Investment.” If Cannasoul fails to achieve a Milestone, the Company will not be obligated to purchase the applicable Milestone Convertible Note. If Cannasoul achieves a Milestone and the Company fails to purchase the applicable Milestone Convertible Note, Cannasoul will have the right to convert all the Company’s Preferred Shares into Cannasoul’s ordinary shares and the Company will lose certain board appointment rights and certain rights in Cannasoul’s subsidiaries. In January 2024, the Company purchased Milestone Convertible Notes for $500,000 following Cannasoul’s achievement of a Milestone. In connection with the Purchase Agreement, Cannasoul adopted amended and restated articles of incorporation (the “Cannasoul Charter”). Pursuant to the Cannasoul Charter, the Company has a number of rights as investor, including (i) the right to appoint and dismiss three of the seven members of Cannasoul’s board of directors and veto power with respect to a fourth member, (ii) preemptive rights to participate pro rata in any pre-initial public offering financings by Cannasoul, (iii) rights of first refusal with respect to transfers of Cannasoul ordinary shares by other investors, (iv) rights of co-sale with respect to proposed sales or transfers of Cannasoul ordinary shares by certain key investors, (v) veto rights with respect to certain major transactions, any amendment to the Cannasoul Charter, approval of Cannasoul’s budget and other items. It was determined that Cannasoul is considered a variable interest entity (“VIE”), but the Company lacks the power to direct the activities that most significantly influence the VIE’s economic performance. As such, the Company is not the primary beneficiary of the VIE and is not required to consolidate Cannasoul in accordance with ASC 810-10-25-38A. The Company’s investment in the Preferred Shares represents an investment in an equity security in accordance with ASC 320. The Preferred Shares are convertible at any time after the date of issuance, automatically upon a payment default, an IPO, or the written consent of the holders of a majority of the Preferred Shares. The conversion price is subject to traditional anti-dilution adjustments. The Company will account for its investment in Cannasoul’s Preferred Shares under the equity method of accounting as it was determined the Company has significant influence over Cannasoul based on its board representation and other veto rights per ASC 323-10-15-6 to The Company has elected to record the equity in earnings of the equity method investment on a three-month lag which is recognized in other comprehensive income (loss). As a result, the Company recorded a loss of $8,600 on its equity method investment during the three months ended March 31, 2024. The Cannasoul Convertible Notes are not traded in active markets and the fair value was determined using a probability weighted scenario-based model. The Cannasoul Convertible Notes are accounted for as an available-for-sale debt security based on “Level 3” inputs, which consist of unobservable inputs and reflect management’s estimates of assumptions that market participants would use in pricing the asset (i.e., implied market rate, risk free rate, share price, and probability of scenarios). Holding gains and losses are recorded in other comprehensive income (loss). Below is a summary of activity for the Cannasoul Convertible Notes as of March 31, 2024: ​ ​ ​ ​ Balance of Cannasoul Convertible Notes as of January 1, 2023 $ — Issued ​ 1,437,598 Change in fair value ​ 902 Balance of Cannasoul Convertible Notes as of December 31, 2023 ​ $ 1,438,500 Issued ​ 500,000 Change in fair value ​ (700) Balance of Cannasoul Convertible Notes as of March 31, 2024 ​ $ 1,937,800 ​ Cognitive Research Enterprises, Inc. (“CRE”) Effective October 31, 2012, the Company executed a Technology License and Services Agreement (the “TLSA”) with CRE, a related party, and NRV II, LLC (“NRV II”), another affiliate of CRE, which was amended by Amendment No. 1 to the TLSA as of August 21, 2013, as amended and restated on February 4, 2015 (the “CRE License Agreement”). Pursuant to the CRE License Agreement, CRE and NRV II provide research services and have granted the Company the exclusive and nontransferable world-wide, royalty-bearing right, with a right to sublicense (in accordance with the terms and conditions described below), under CRE’s and NRV II’s respective right, title and interest in and to certain patents and technology owned by CRE or licensed to NRV II by CRE as of or subsequent to October 31, 2012, to develop, use, manufacture, market, offer for sale, sell, distribute, import and export certain products or services for therapeutic applications for AD and other cognitive dysfunctions in humans or animals (the “Field of Use”). Additionally, the CRE License Agreement specifies that all patents that issue from a certain patent application shall constitute licensed patents and all trade secrets, know-how and other confidential information claimed by such patents constitute licensed technology under the CRE License. The CRE License Agreement terminates on the later of the date (a) the last of the licensed patent expires, is abandoned, or is declared unenforceable or invalid or (b) the last of the intellectual property enters the public domain. After Neurotrope’s initial Series A Stock financing, the CRE License Agreement required the Company to enter into scope of work agreements with CRE as the preferred service provider for any research and development services or other related scientific assistance and support services. There were no such statements of work agreements entered into during the years ended December 31, 2022 and 2021, respectively, or during the three months ended March 31, 2024. In addition, on November 10, 2018, the Company and CRE entered into a second amendment (the “Second Amendment”) to the TLSA pursuant to which CRE granted certain patent prosecution and maintenance rights to the Company. Under the Second Amendment, the Company will have the sole and exclusive right and the obligation, to apply for, file, prosecute and maintain patents and applications for the intellectual property licensed to the Company, and pay all fees, costs and expenses related to the licensed intellectual property.

Related Party Transactions_

Related Party Transactions:	3 Months Ended
	Mar. 31, 2024
Related Party Transactions:
Related Party Transactions:	Note 4- Related Party Transactions: On August 4, 2016, Neurotrope entered into a consulting agreement with SM Capital Management, LLC (“SMCM”), a limited liability company owned and controlled by the Company’s Chairman of the Board, Mr. Joshua N. Silverman (the “Consulting Agreement”). Pursuant to the Consulting Agreement, SMCM shall provide consulting services which shall include, but not be limited to, providing business development, financial communications and management transition services, for a one-year period, subject to annual review thereafter. SMCM’s annual consulting fee is $120,000, payable by the Company in monthly installments of $10,000. This contract was assigned to the Company as of December 1, 2020. For the three months ended March 31, 2024 and 2023, $30,000 is reflected in the Company’s statements of comprehensive loss, respectively.

Other Commitments_

Other Commitments:	3 Months Ended
	Mar. 31, 2024
Other Commitments:
Other Commitments:	Note 5 – Other Commitments: Clinical Trial Services Agreements On July 23, 2020, the Company entered into a services agreement with WCT (the “2020 Services Agreement”). The 2020 Services Agreement related to services for the current Phase 2 clinical trial assessing the safety, tolerability and long-term efficacy of Bryostatin-1 in the treatment of moderately severe AD subjects not receiving memantine treatment (the “2020 Study”).On January 22, 2022, the Company executed a change order with WCT to accelerate trial subject recruitment totaling approximately $1.4 million. In addition, on February 10, 2022, the Company signed an additional agreement with a third-party vendor to assist with the increased trial recruitment retention totaling approximately $1.0 million which was subsequently canceled with no charges incurred by the Company. The updated total estimated budget for these trial services, including pass-through costs, was approximately $11.0 million. As noted below, Neurotrope was granted a $2.7 million award from the National Institutes of Health, which award was used to support the Phase 2 Study, resulting in an estimated net budgeted cost of the Phase 2 Study to Neurotrope of $9.3 million. The Company was awarded a $2.7 million grant from the NIH, which will be used to support the 2020 Study, resulting in an estimated net budgeted cost of the 2020 Study to the Company of $8.3 million. The NIH grant provided for funds in the first year, which began in April 2020, of approximately $1.0 million and funding in year two, which began April 2021, of approximately $1.7 million. As of February 22, 2022, virtually all of the NIH grant had been received and offset against the clinical trial costs. The Company incurred approximately $11.2 million of cumulative expenses associated with the current Phase 2 clinical trial as of March 31, 2024. Of the total $11.2 million incurred for the trial as of March 31, 2024, $0 and $0.3 million is reflected in the statement of comprehensive loss for the three months ended March 31, 2024 and 2023, respectively. The 2020 Study was completed in December 2023. On May 12, 2022, the Company entered into a services agreement with WCT (the “2022 Services Agreement”). The 2022 Services Agreement related to services for a Phase 2 “open label,” dose ranging study, clinical trial assessing the safety, tolerability and efficacy of Bryostatin-1 administered via infusion in the treatment of moderately severe to severe AD subjects not receiving memantine treatment (the “2022 Study”). Pursuant to the terms of the 2022 Services Agreement, WCT provided services to enroll approximately twelve 2022 Study subjects. The first 2022 Study site was initiated during the third quarter of 2022. The total estimated budget for the services, including pass-through costs, is currently approximately $2.0 million. The Company terminated the 2022 Services Agreement in December 2022. The Company incurred approximately $1.6 million of cumulative expenses associated with the current 2022 Study as of March 31, 2024. Of the total $1.6 million incurred for the trial as of March 31, 2024, $0 and approximately $124,000 is reflected in the statement of comprehensive loss for the three months ended March 31, 2024 and 2023, respectively. Employment Agreements On December 7, 2020, the Company entered into an offer letter (as amended on August 4, 2022 and June 16, 2023, the “Offer Letter”) with Alan J. Tuchman, M.D., pursuant to which Dr. Tuchman agreed to serve as the Company’s Chief Executive Officer, commencing on December 7, 2020. In addition, in connection with his appointment as the Company’s Chief Executive Officer, Dr. Tuchman was appointed to the board of directors of the Company. Dr. Tuchman receives an annual base salary of $222,000, with an annual discretionary bonus of up to 50% of his base salary then in effect.The term of Dr. Tuchman’s employment pursuant to the Offer Letter is through June 7, 2024, with automatic monthly renewals thereafter unless earlier terminated in accordance with the terms of the Offer Letter. Pursuant to the Offer Letter, if Dr. Tuchman is terminated without cause, Dr. Tuchman shall be entitled to severance equal to six months of Dr. Tuchman’s annual base salary. Other Commitments and Agreements See Notes 3 and 4 for Collaboration and License Agreement related commitments. Contingencies Pursuant to the Separation Agreement and Tax Matters Agreement with Neurotrope, Neurotrope agreed to indemnify Synaptogenix for certain liabilities, and Synaptogenix agreed to indemnify Neurotrope for certain liabilities, in each case for uncapped amounts. Indemnities that Synaptogenix may be required to provide Neurotrope are not subject to any cap, may be significant and could negatively impact Synaptogenix’s business, particularly with respect to indemnities provided in the Tax Matters Agreement. Third parties could also seek to hold Synaptogenix responsible for any of the liabilities that Neurotrope has agreed to retain. Further, the indemnity from Neurotrope may not be sufficient to protect Synaptogenix against the full amount of such liabilities, and Neurotrope may not be able to fully satisfy its indemnification obligations. Moreover, even if Synaptogenix ultimately succeeds in recovering from Neurotrope any amounts for which Synaptogenix is held liable, Synaptogenix may be temporarily required to bear these losses ourselves. As of the reporting date, there are no claims relating to the indemnification agreement.

Stockholders' Equity_

Stockholders' Equity:	3 Months Ended
	Mar. 31, 2024
Stockholders' Equity:
Stockholders' Equity:	Note 6 – Stockholders’ Equity: The Company’s certificate of incorporation authorizes it to issue 150,000,000 shares of Common Stock and 1,000,000 shares of preferred stock, par value $0.0001 per share. The holders of Common Stock are entitled to receive dividends out of assets or funds legally available for the payment of dividends at such times and in such amounts as the Board from time to time may determine. To date, the Company has not paid dividends on its Common Stock. Holders of Common Stock are entitled to one vote for each share held on all matters submitted to a vote of stockholders. There is no cumulative voting of the election of directors then standing for election. The Common Stock is not entitled to pre-emptive rights and is not subject to conversion or redemption. Upon liquidation, dissolution or winding up of the Company, the assets legally available for distribution to stockholders are distributable ratably among the holders of Common Stock after payment of liabilities, accrued dividends and liquidation preferences, if any. Each outstanding share of Common Stock is duly and validly issued, fully paid and non-assessable. November 2022 Private Placement On November 17, 2022, the Company entered into a Securities Purchase Agreement (as amended on May 11, 2023, the “November Purchase Agreement”) with certain accredited investors (the “November Investors”), pursuant to which it agreed to sell to the November Investors (i) an aggregate of 15,000 shares of the Company’s newly-designated Series B convertible preferred stock with a stated value of $1,000 per share (the “Series B Preferred Stock”), initially convertible into up to 77,420 shares of Common Stock at a conversion price of $193.75 per share (the “Series B Preferred Shares”), and (ii) warrants to acquire up to an aggregate of 77,420 shares of Common Stock (the “November Warrants”) (collectively, the “November Private Placement”). The terms of the Series B Preferred Stock are as set forth in the Certificate of Designations for the Series B Preferred Stock (as amended on March 17, 2023, May 12, 2023 and September 22, 2023, the “Certificate of Designations”). The Series B Preferred Stock will be convertible into Series B Preferred Shares at the election of the holder at any time at an initial conversion price of $193.75 (the “Conversion Price”). The Conversion Price is subject to customary adjustments for stock dividends, stock splits, reclassifications and the like, and subject to price-based adjustment in the event of any issuances of Common Stock, or securities convertible, exercisable or exchangeable for Common Stock, at a price below the then-applicable Conversion Price (subject to certain exceptions). The Company will be required to redeem the Series B Preferred Stock in 15 equal monthly installments, commencing on June 1, 2023. The amortization payments due upon such redemption are payable, at the Company’s election, in cash, or subject to certain limitations, in shares of Common Stock valued at the lower of (i) the Conversion Price then in effect and (ii) the greater of (A) a 15% discount to the average of the three lowest closing prices of the Common Stock during the thirty On March 17, 2023, the Company filed an amendment (the “First CoD Amendment”) to the Certificate of Designations with the Secretary of State for the State of Delaware, pursuant to which it amended the terms of the Series B Preferred Stock by revising the definition of “floor price” for purposes of calculating amortization payments, extending the date for the first required amortization payments, extending the deadline for stockholder approval and extending the maturity date to August 31, 2024. On May 12, 2023, the Company filed an amendment (the “Second CoD Amendment”) to the Certificate of Designations with the Secretary of State for the State of Delaware, pursuant to which the Company amended the terms of the Series B Preferred Stock by removing all references to the “Make-Whole Amount”. In connection with the Second CoD Amendment, on May 11, 2023, the Company entered into an amendment to the November Purchase Agreement pursuant to which it agreed to extend the investors’ right of participation in a subsequent financing until the one year anniversary following the later of (x) such time that the Series B Preferred Shares are no longer outstanding and (y) the maturity date of the Series B Preferred Stock. On September 22, 2023, the Company filed an amendment (the “Third CoD Amendment”) to the Certificate of Designations with the Secretary of State for the State of Delaware, pursuant to which the Company amended the terms of the Series B Preferred Stock by providing that the Company and November Investors shall be permitted to mutually agree, in connection with any waiver of an Equity Conditions Failure (as defined in the Certificate of Designations), as to (i) whether the monthly amortization payments made to the Investors will be made in cash or shares of Common Stock, (ii) the methodology for calculating any applicable true-up shares required to be paid in connection with an amortization payment (including whether such true-up shares will be paid in cash or shares of Common Stock) and for calculating the conversion price in connection with any accelerated conversions, and (iii) whether any premium will apply in connection with any payment of true-up shares in cash instead of shares of Common Stock, subject to certain limitations as set forth in the Third CoD Amendment. The holders of the Series B Preferred Stock will be entitled to dividends of 7% per annum, compounded monthly, which will be payable in cash or shares of Common Stock at the Company’s option, in accordance with the terms of the Certificate of Designations. Upon the occurrence and during the continuance of a Triggering Event (as defined in the Certificate of Designations), the Series B Preferred Stock will accrue dividends at the rate of 15% per annum. The holders of Series B Preferred Stock have no voting rights on account of the Series B Preferred Stock, other than with respect to certain matters affecting the rights of the Series B Preferred Stock. Notwithstanding the foregoing, the Company’s ability to settle conversions and make amortization payments using shares of Common Stock is subject to certain limitations set forth in the Certificate of Designations, including a limit on the number of shares that may be issued until the time, if any, that the Company’s stockholders have approved the issuance of more than 19.9% of the Company’s outstanding shares of Common Stock in accordance with Nasdaq listing standards (the “Nasdaq Stockholder Approval”). The Company agreed to seek stockholder approval of these matters at a meeting to be held no later than June 1, 2023, and such approval was obtained at the Company’s special meeting of stockholders held on April 14, 2023. Further, the Certificate of Designations contains a certain beneficial ownership limitation after giving effect to the issuance of shares of Common Stock issuable upon conversion of, or as part of any amortization payment under, the Certificate of Designations or November Warrants. The Certificate of Designations includes certain Triggering Events (as defined in the Certificate of Designations), including, among other things, the failure to file and maintain an effective registration statement covering the sale of the holder’s securities registrable pursuant to the November Registration Rights Agreement (defined below) and the Company’s failure to pay any amounts due to the holders of the Series B Preferred Stock when due. In connection with a Triggering Event, each holder of Series B Preferred Stock will be able to require the Company to redeem in cash any or all of the holder’s Series B Preferred Stock at a premium set forth in the Certificate of Designations. The Company will be subject to certain affirmative and negative covenants regarding the incurrence of indebtedness, acquisition and investment transactions, the existence of liens, the repayment of indebtedness, the payment of cash in respect of dividends (other than dividends pursuant to the Certificate of Designations), distributions or redemptions, and the transfer of assets, among other matters. The November Warrants are exercisable for Warrant Shares immediately at an exercise price of $193.75 per share (the “Exercise Price”) and expire five years from the date of issuance. The Exercise Price is subject to customary adjustments for stock dividends, stock splits, reclassifications and the like, and subject to price-based adjustment, on a “full ratchet” basis, in the event of any issuances of Common Stock, or securities convertible, exercisable or exchangeable for Common Stock, at a price below the then-applicable Exercise Price (subject to certain exceptions). There is no established public trading market for the November Warrants and the Company does not intend to list the November Warrants on any national securities exchange or nationally recognized trading system. In connection with the November Purchase Agreement, the Company and the November Investors entered into a Registration Rights Agreement (the “November Registration Rights Agreement”) on November 17, 2022. Under the terms of the November Registration Rights Agreement, the Company agreed to register 200% of the Series B Preferred Shares, the Warrant Shares and the shares of Common Stock issuable as amortization payments as well as any shares of Common Stock paid as dividends. The Company filed a registration statement for the resale of such securities on December 16, 2022. The Company also agreed to other customary obligations regarding registration, including indemnification and maintenance of the effectiveness of the registration statement. In connection with the November Private Placement, pursuant to an Engagement Letter, between the Company and Katalyst Securities LLC (the “November Placement Agent”), the Company paid the November Placement Agent (i) a cash fee equal to 7% of the gross proceeds from any sale of securities in the November Private Placement and (ii) warrants to purchase shares of Common Stock equal to 3% of the number of shares of Common Stock that the Series B Preferred Shares are initially convertible into, with an exercise price of $193.75 per share and a five-year term. During the three months ended March 31, 2024, the Company redeemed $3,000,000 of the Series B Preferred Stock and $87,500 of accrued dividends by issuing 106,126 shares of Common Stock through installment conversions and proportionately relieved $2,455,656 of discount related to the redeemed Series B Preferred Stock. During the three months ended March 31, 2024, the Company recognized a deemed dividend of $130,959 related to cash premiums. As of March 31, 2024 and December 31, 2023, the Company has accrued a liability for installment payments owed to investors in either cash or shares of $6,015,115 and $3,395,945, respectively. Subsequent to March 31, 2024, and as of May 13, 2024, the Company has issued 147,896 shares of Common Stock in partial satisfaction of the accrued preferred redemption liability. The Company effected the Reverse Stock Split on April 4, 2024. Pursuant to the terms of the Certificate of Designations and the November Warrants, the exercise price of November Warrants and the conversion price of the Series B Preferred Stock were proportionately adjusted. Accounting Treatment of November Private Placement Series B Preferred Shares Effective March 17, 2023, the Company filed the First CoD Amendment. The First CoD Amendment modified (i) the definition of Floor Price to mean the lower of (i) $31.25 and (ii) 20% of the “Minimum Price” (as defined in Rule 5635 of the Rule of the Nasdaq Stock Market) on the date of receipt of Stockholder Approval (as defined in the Agreement), (ii) the definition of Installment Date to mean June 1, 2023, and thereafter, the first Trading Day of each calendar month immediately following the previous Installment Date until the Maturity Date, and the Maturity Date, and (iii) the definition of Maturity Date to mean August 31, 2023. In accordance with ASC 470-50 and 470-60, the Company has made an accounting policy election to account for amendments of the Series B Preferred Stock as modifications or extinguishments based on the change in fair value of the instrument immediately before and immediately after the amendment. The Company accounted for the First CoD Amendment as an extinguishment as the change in fair value of the Series B Preferred Stock was 34% (greater than ten percent (10%)) immediately before and immediately after. In accordance with ASC 260-10-S99-2, the Company recognized the $5.7 million increase in fair value as a deemed dividend on the statement of operations. On May 11, 2023, the Company filed the Second CoD Amendment. The Second CoD Amendment removed the definition of Make-Whole Amount (as was previously defined in the Agreement) and modified the definition of the Conversion Amount so as to remove the Make-Whole Amount from said definition. In accordance with ASC 470-50 and 470-60, the Company accounted for the amendment as a modification as the change in fair value of the Series B Preferred Stock was 0.05% (less than ten percent (10%)) immediately before and immediately after. The Company analogized to the share-based payments model for the appropriate modification accounting and did not recognize a deemed dividend as the fair value decreased upon modification. The Series B Preferred Shares were determined to be more akin to a debt-like host than an equity-like host. The Company identified the following embedded features that are not clearly and closely related to the debt host instrument: 1) make-whole interest upon a contingent redemption event, 2) make-whole interest upon a conversion event, 3) an installment redemption upon an Equity Conditions Failure (as defined in the Certificate of Designations), and 4) variable share-settled installment conversion. These features were bundled together, assigned probabilities of being affected and measured at fair value. Subsequent changes in fair value of these features are recognized in the Consolidated Statement of Operations. The Company estimated the $2.2 million fair value of the bifurcated embedded derivative at issuance using a Monte Carlo simulation model, with the following inputs: the fair value of the Common Stock of $163.00 on the issuance date, estimated equity volatility of 85.0%, estimated traded volume volatility of 255.0%, the time to maturity of 1.61 years, a discounted market interest rate of 7.3%, dividend rate of 7%, a penalty dividend rate of 15.0%, and probability of default of 8.2%. The fair value of the bifurcated derivative liability was estimated utilizing the with and without method which uses the probability weighted difference between the scenarios with the derivative and the plain vanilla maturity scenario without a derivative. The discount to the fair value is included as a reduction to the carrying value of the Series B Preferred Shares. During 2022, the Company recorded a total discount of approximately $12.3 million upon issuance of the Series B Preferred Shares, which was comprised of the issuance date fair value of the associated embedded derivative of approximately $2.2 million, stock issuance costs of approximately $0.5 million and the fair value of the Warrants of approximately $9.6 million. During the three months ended March 31, 2024, it was deemed probable that the Series B Preferred Shares will be redeemed for Common Stock upon Installment Redemptions (as defined the Certificate of Designations). As such, the Company recognized $2,455,656 to additional paid-in capital to accrete the Series B Preferred Shares to redemption amount pursuant to ASC 480-10-S99-3A with a corresponding increase in the carrying value of the Series B Preferred Shares. During the three months ended March 31, 2024 and 2023, the Company recorded a gain of $972,000 and $225,800, respectively. which is recorded in other income (expense) on the statements of comprehensive loss. The Company estimated the $141,000 fair value of the bifurcated embedded derivative at March 31, 2024 using a Monte Carlo simulation model, with the following inputs: the fair value of the Common Stock of $4.75 per share on the valuation date, estimated equity volatility of 120%, estimated traded volume volatility of 215%, the time to maturity of 0.42 years, a discounted market interest rate of 6.2%, dividend rate of 7%, a penalty dividend rate of 15.0%, and probability of default of 2.1%. Common Stock Warrants Pursuant to the Private Placement, the Company issued to investors Warrants and, pursuant to its advisory agreements, the Company issued to its advisor additional Warrants with the same terms. The Broker Warrants are within the scope of ASC 718 pursuant to ASC 718-10-20 but are subject to liability classification as they would be required to be classified as liabilities in accordance with ASC 480. The Warrants were determined to be within the scope of ASC 480-10 as they are puttable to the Company at Holders’ election upon the occurrence of a Fundamental Transaction (as defined in the agreements). As such, the Company recorded the Warrants as a liability at fair value with subsequent changes in fair value recognized in earnings. The Company utilized the Black Scholes Model to calculate the value of these warrants issued during the year ended December 31, 2023. The fair value of the Warrants of approximately $9.9 million was estimated at the date of issuance using the following weighted average assumptions: dividend yield 0%; expected term of five years; equity volatility of 105%; and a risk-free interest rate of 3.97%. Transaction costs incurred attributable to the issuance of the Warrants of $0.9 million were immediately expensed in accordance with ASC 480. During the three months ended March 31, 2024 and 2023, the Company recorded a gain of $58,000 and $588,000, respectively, related to the change in fair value of the warrant liability, which is recorded in other income (expense) on the statements of comprehensive loss. The fair value of the Warrants of approximately $82,000 was estimated at March 31, 2024 utilizing the Black Scholes Model using the following weighted average assumptions: dividend yield 0%; remaining term of 3.63 years; equity volatility of 120%; and a risk-free interest rate of 4.34%. Reverse Stock Split At the Company’s annual meeting of stockholders held on December 20, 2023, the stockholders approved an amendment to the Company’s amended and restated certificate of incorporation to effect one reverse stock split of the Company’s outstanding shares of Common Stock, at any ratio between 1-for-8 1-for-25 Based upon the Reverse Stock Split and pursuant to the November Private Placement, the total number of November Warrants held by the November Investors has been adjusted to 3,318,586 with an exercise price of $4.4437 per share. In addition, the Conversion Price is adjusted to $4.4437 per Series A Preferred Share. The effect of these adjustments will be reflected in the Company’s second quarter 2024 financial statements.

Stock Based Compensation_

Stock Based Compensation:	3 Months Ended
	Mar. 31, 2024
Stock Based Compensation:
Stock Based Compensation:	Note 7 – Stock Based Compensation: 2020 Equity Incentive Plan Upon completion of the Spin-Off, the Company’s 2020 Equity Incentive Plan (the “2020 Plan”) became effective on December 7, 2020. On December 20, 2023, the Company held its annual meeting of stockholders at which time the Company’s stockholders approved an amendment to the Company’s 2020 Plan was amended to increase the total number of shares of Common Stock authorized for issuance from 55,000 to an aggregate of 175,000 shares. The Compensation Committee of the Company’s board of directors (the “Committee”) administers the 2020 Plan and has full power to grant stock options and Common Stock, construe and interpret the 2020 Plan, establish rules and regulations and perform all other acts, including the delegation of administrative responsibilities, as it believes reasonable and proper. The Committee, in its absolute discretion, may award Common Stock to employees, consultants, and directors of the Company, and such other persons as the Committee may select, and permit holders of options to exercise such options prior to full vesting. Stock and Option Grants The following is a summary of stock option activity under the stock option plans for the three months ended March 31, 2024: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted- ​ ​ ​ ​ ​ ​ ​ Average ​ Aggregate ​ ​ ​ ​ Weighted- ​ Remaining ​ Intrinsic ​ ​ Number ​ Average ​ Contractual ​ Value ​ ​ of ​ Exercise ​ Term ​ (in ​ ​ Shares ​ Price ​ (Years) ​ millions) Options outstanding at January 1, 2024 29,674 ​ $ 153.75 6.15 ​ $ — Options granted — ​ $ — — ​ — Less options forfeited — ​ $ — — ​ — Less options expired/cancelled — ​ $ — — ​ — Less options exercised — ​ $ — — ​ — Options outstanding at March 31, 2024 29,674 ​ $ 153.75 5.90 ​ $ — Options exercisable at March 31, 2024 26,474 ​ $ 169.75 8.30 ​ $ — ​ The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying awards and the closing price of the Common Stock, which was $4.70 per share on March 31, 2024 and $6.80 per share on December 31, 2023. As of March 31, 2024, the Company had unrecognized stock option expense of $0 and a remaining weighted average period for recognition of 0 years. On April 8, 2024, Synaptogenix granted stock options to four Board members to purchase an aggregate of 3,200 shares of Common Stock. The stock options have an exercise price of $5.39 per share and an expiration date of ten years. They vest on the one-year anniversary from the date of the grant. The Company used the Black Scholes valuation method to determine the fair value of the options assuming the following: implied volatility of 124.35%, a risk free interest rate of 4.43% and have an aggregate fair value of $18,601. Director’s Compensation Policy On March 29, 2023, Synaptogenix adopted an amended and restated non-employee director compensation policy (the “Director Compensation Policy”). The Director Compensation Policy provides for the annual automatic grant of nonqualified stock options to purchase up to 800 shares of Synaptogenix’s Common Stock to each of Synaptogenix’s non-employee directors. Such grants shall occur annually on the fifth business day after the filing of Synaptogenix’s Annual Report on Form 10-K, if available under the Plan, and shall vest on the one-year anniversary from the date of grant, subject to the director’s continued service on the Board of Directors on the vesting date. Each newly appointed or elected director will also receive 800 options, and such options shall vest 50% on the grant date, 25% on the first anniversary of the grant date and 25% on the second anniversary of the grant date, subject to the director’s continued service on the Board of Directors on each vesting date. On April 8, 2024, the Company issued options to purchase a total of 3,200 shares of common stock at an exercise price of $5.39 per share to four directors pursuant to the Director Compensation Policy. The Company recorded total expenses relating to the outstanding stock options of $14,407 and $644,781 for the three months ended March 31, 2024 and 2023, respectively. Restricted Stock Issuances On January 5, 2023, the Company issued 3,533 shares of restricted stock to a consultant that was engaged to provide investor relations services with a total fair market value on date of issuance of $100,000 expensed upon issuance. On March 22, 2023, the Company issued 180 shares of restricted stock to a consultant that was engaged to provide investor relations services with a total fair market value on date of issuance of $4,500, expensed upon issuance. On January 8, 2024, the Company issued 14,641 shares of restricted stock to a consultant that was engaged to provide investor relations services with a total fair market value on date of issuance of $100,000, expensed upon issuance. On March 7, 2024, the Company issued 981 shares of restricted stock to a consultant that was engaged to provide investor relations services with a total fair market value on date of issuance of $4,500, expensed upon issuance. Stock Compensation Expense Total stock-based compensation for the three months ended March 31, 2024 and 2023 was $14,407 and 644,781, respectively, of which $0 and $99,726, respectively, was classified as research and development expense, and $14,407 and $545,055 was classified as general and administrative expense, respectively. The Company currently estimates, beginning at the closing date of the November Private Placement, implied volatility factor for all options and warrants based upon a blend of the Parent Company’s and Company’s historical volatility. Up until November 21, 2022, the Company computed implied volatility based upon a blend of the Parent Company’s and Company’s historical volatility along with the volatility of selected comparable publicly traded companies as, at that time, the Company lacked sufficient historical stock trading activity. It incorporated the historical volatility of the Parent Company as the Parent Company’s historical volatility provides a good estimation of the Company’s volatility since its operations were identical to the Company’s prior to the spin-out.

Common Stock Warrants_

Common Stock Warrants:	3 Months Ended
	Mar. 31, 2024
Common Stock Warrants:
Common Stock Warrants:	Note 8 – Common Stock Warrants: As of March 31, 2024, the Company had warrants outstanding consisting of the following: ​ ​ ​ ​ ​ Number ​ ​ of shares Warrants outstanding January 1, 2023 287,436 Warrants issued — Warrants exercised — Warrants expired ​ — Warrants outstanding and exercisable March 31, 2024 287,436 ​ As of March 31, 2024, the weighted average exercise price and the weighted average remaining life of the total warrants were $296.57 per warrant and 2.41 years, respectively. The intrinsic value of the warrants as of March 31, 2024 was approximately $24,000. The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying awards and the closing price of the Common Stock, which was $4.70 per share on March 31, 2024.

Fair Value on a Recurring Basis

Fair Value on a Recurring Basis	3 Months Ended
	Mar. 31, 2024
Fair Value on a Recurring Basis
Fair Value on a Recurring Basis	Note 9 - Fair Value on a Recurring Basis The Company follows the guidance in ASC 820 for its financial assets and liabilities that are re-measured and reported at fair value at each reporting period, and non-financial assets and liabilities that are re-measured and reported at fair value at least annually. The estimated fair value of the warrant liability and bifurcated embedded derivatives represent Level 3 measurements. The following table presents information about the Company’s liabilities that are measured at fair value on a recurring basis at March 31, 2024 and December 31, 2023, and indicates the fair value hierarchy of the valuation inputs the Company utilized to determine such fair value: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ December 31, Description Level 2024 2023 Liabilities: ​ ​ Warrant liability (Note 6) 3 ​ $ 82,000 ​ $ 140,000 Bifurcated embedded derivative liability (Note 6) 3 ​ $ 141,000 ​ $ 1,113,000 ​ The following table sets forth a summary of the change in the fair value of the warrant liability that is measured at fair value on a recurring basis: ​ ​ ​ ​ ​ ​ March 31, 2024 Balance on December 31, 2022 ​ $ 1,510,000 Change in fair value of warrant liability ​ (1,370,000) Balance on December 31, 2023 ​ $ 140,000 Change in fair value of warrant liability ​ (58,000) Balance on March 31, 2024 ​ $ 82,000 ​ The following table sets forth a summary of the change in the fair value of the bifurcated embedded derivative liability that is measured at fair value on a recurring basis: ​ ​ ​ ​ ​ ​ March 31, 2024 Balance on December 31, 2022 ​ $ 369,400 Change in fair value of bifurcated embedded derivative ​ (743,600) Balance on December 31, 2023 ​ $ 1,113,000 Change in fair value of warrant liability ​ (972,000) Balance on March 31, 2024 ​ $ 141,000 ​

Subsequent Events

Subsequent Events	3 Months Ended
	Mar. 31, 2024
Subsequent Events
Subsequent Events	Note 10 – Subsequent Events ​ Refer to Notes 6 and 7 for disclosure of applicable subsequent events.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies: (Policies)	3 Months Ended
	Mar. 31, 2024
Summary of Significant Accounting Policies:
Basis of Presentation:	Basis of Presentation: The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial reporting and with the instructions to Form 10-Q and Article 10 of Regulation S-X. In the opinion of management, the unaudited condensed financial statements included herein contain all adjustments necessary to present fairly the Company’s financial position and the results of its operations and cash flows for the interim periods presented. Such adjustments are of a normal recurring nature. The results of operations for the three months ended March 31, 2024 may not be indicative of results for the full year. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and the notes to those statements for the year ended December 31, 2023 included in the Company’s Annual Report on Form 10-K filed with the SEC on April 1, 2024. The Company is an emerging growth company as the term is used in The Jumpstart Our Business Startups Act, enacted on April 5, 2012, and has elected to comply with certain reduced public company reporting requirements, however, the Company may adopt accounting standards based on the effective dates for public entities.
Use of Estimates:	Use of Estimates: The preparation of financial statements in conformity with GAAP requires management to make significant estimates that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of expenses during the reporting period. Management evaluates its estimates on an ongoing basis using historical experience and other factors, including the general economic environment and actions it may take in the future. The Company adjusts such estimates when facts and circumstances dictate. However, these estimates may involve significant uncertainties and judgments and cannot be determined with precision. In addition, these estimates are based on management’s best judgment at a point in time and as such these estimates may ultimately differ from actual results.
Comprehensive Income (Loss)	Comprehensive Income (Loss) The Company follows The Company follows Financial Accounting Standards Board (“FASB”) Accounting Standards Codification (“ASC”) 220 in reporting comprehensive income (loss). Comprehensive income (loss) is a more inclusive financial reporting methodology that includes disclosure of certain financial information that historically has not been recognized in the calculation of net income (loss). Since the Company has items of other comprehensive income (loss), comprehensive income (loss) has been reflected in the Company’s financial statements.
Net Earnings or Loss per Share:	Net Earnings or Loss per Share: Net earnings or loss per share is computed by dividing net income or loss by the weighted-average number of shares of Common Stock outstanding during the period, excluding shares subject to redemption or forfeiture. The Company presents basic and diluted net earnings or loss per share. Diluted net earnings or loss per share reflect the actual weighted average of shares of Common Stock issued and outstanding during the period, adjusted for potentially dilutive securities outstanding. Potentially dilutive securities are excluded from the computation of the diluted net earnings or loss per share if their inclusion would be anti-dilutive. As all potentially dilutive securities are anti-dilutive as of March 31, 2024 and 2023, diluted net loss per share is the same as basic net loss per share for the three months ended March 31, 2024 and 2023. The weighted average dilutive securities that have been excluded from the calculation of diluted net loss per share for the three months ended March 31, 2024 and 2023 respectively, because to do so would be anti-dilutive (in Common Stock equivalents), are as follows: ​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ March 31, ​ 2024 2023 Common Stock Options 29,674 29,674 Convertible Preferred Stock ​ 46,530 ​ — Common Stock Warrants 287,436 287,197 Total 363,640 316,871
Cash and Cash Equivalents and Concentration of Credit Risk:	Cash and Cash Equivalents and Concentration of Credit Risk: The Company considers all highly liquid cash investments with an original maturity of three months or less when purchased to be cash equivalents. At March 31, 2024, the Company’s cash balances that exceed the current insured amounts under the Federal Deposit Insurance Corporation (“FDIC”) were approximately $0.4 million. In addition, approximately $25.9 million included in cash and cash equivalents were invested in a money market fund and in U.S. treasury bills, which is not insured under the FDIC.
Investment in Debt Securities	Investment in Debt Securities The Company’s convertible note receivable was determined to be an available-for-sale debt security under ASC 320, Investments,
Fair Value of Financial Instruments:	Fair Value of Financial Instruments: The carrying amounts reflected in the balance sheets for prepaid expenses and payables approximate fair value due to the short maturities of these instruments. The carrying amounts for available for sale debt security, warrant liability and derivative liability approximate fair value based on level 3 of the fair value hierarchy. Certain assets and liabilities are carried at fair value under GAAP. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. Financial assets and liabilities carried at fair value are to be classified and disclosed in one of the following three levels of the fair value hierarchy: Level 1 — Quoted prices in active markets for identical assets or liabilities. Level 2 — Observable inputs (other than Level 1 quoted prices), such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active for identical or similar assets or liabilities, or other inputs that are observable or can be corroborated by observable markets. Level 3 — Unobservable inputs which are supported by little or no market activity and that are significant to determining the fair value of the assets or liabilities, including pricing models, discounted cash flow methodologies and similar techniques.
Fixed Assets and Leases:	Fixed Assets and Leases: The Company has two leases, both of which have a term of one year during the respective reporting periods. The Company has deemed the leases immaterial and has not recorded it as an obligation on the balance sheet nor a right-of-use asset. The total future expense relating to these leases is approximately $40,000 per year. Fixed assets are stated at cost less accumulated depreciation. Depreciation is computed on a straight line basis over the estimated useful life of the asset, which is deemed to be between three
Research and Development Costs:	Research and Development Costs: All research and development costs, including costs to maintain or expand the Company’s patent portfolio licensed from CRE are expensed when incurred. Non-refundable advance payments for research and development are capitalized because the right to receive those services represents an economic benefit. Such capitalized advances will be expensed when the services occur and the economic benefit is realized. There were no capitalized research and development services, other than non-refundable advance payments as mentioned below for The Cleveland Clinic Foundation (“Cleveland Clinic”), at March 31, 2024 and December 31, 2023.
Income Taxes:	Income Taxes: The Company accounts for income taxes using the asset and liability approach which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of temporary differences between the carrying amount of assets and liabilities for financial reporting purposes and amounts reportable for income tax purposes under the “Separate return method.” Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized. The Company applies the provisions for accounting for uncertainty in income taxes recognized in an enterprise’s financial statements and prescribes a recognition threshold and measurement process for financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. The Company has determined that there are no significant uncertain tax positions requiring recognition in the accompanying financial statements. The tax period that is subject to examination by major tax jurisdictions is generally three years from the date of filing. The Company had federal operating loss carryforwards for income tax purposes of approximately $95.9 million for the period from October 31, 2012 (inception) through March 31, 2024. The net operating loss carryforwards and other deferred tax assets resulted in Federal and state deferred tax assets of approximately $30.6 million at March 31, 2024. Income tax effects of share-based payments are recognized in the financial statements for those awards that will normally result in tax deductions under existing tax law. However, the deferred tax asset is offset by a full valuation allowance. The Company may be subject to significant U.S. federal income tax-related liabilities with respect to the Spin-Off if there is a determination that the Spin-Off is taxable for U.S. federal income tax purposes. In connection with the Spin-Off, the Company believes that, among other things, the Spin-Off should qualify as a tax-free transaction for U.S. federal income tax purposes under Section 355 and Section 368(a)(1)(D) of the Internal Revenue Code of 1986 (the “Code”). If the conclusions of the tax opinions are not correct, or if the Spin-Off is otherwise ultimately determined to be a taxable transaction, the Company would be liable for U.S. federal income tax related liabilities. Pursuant to the Separation and Distribution Agreement and the Tax Matters Agreement, Neurotrope agreed to indemnify Synaptogenix for certain liabilities, and Synaptogenix agreed to indemnify Neurotrope for certain liabilities, in each case for uncapped amounts. Indemnities that Synaptogenix may be required to provide Neurotrope are not subject to any cap, may be significant and could negatively impact Synaptogenix’s business, particularly with respect to indemnities provided in the Tax Matters Agreement. Third parties could also seek to hold Synaptogenix responsible for any of the liabilities that Neurotrope has agreed to retain. Further, the indemnity from Neurotrope may not be sufficient to protect Synaptogenix against the full amount of such liabilities, and Neurotrope may not be able to fully satisfy its indemnification obligations. Moreover, even if Synaptogenix ultimately succeeds in recovering from Neurotrope any amounts for which Synaptogenix is held liable, Synaptogenix may be temporarily required to bear these losses. At December 31, 2023 and as of the date of financial statement issuance date, the Company does not have any indemnification liabilities. Under Section 382 of the Code, as amended, changes in the Company’s ownership may limit the amount of its net operating loss carryforwards that could be utilized annually to offset future taxable income, if any. This limitation would generally apply in the event of a cumulative change in ownership of the Company of more than 50% within a three-year period. In addition, the significant historical operating losses incurred by the Company may limit the amount of its net operating loss carryforwards that could be utilized annually to offset future taxable income, if any. The Company believes that operating loss carryforwards may be limited under Section 382 limitations although Section 382 studies have not been conducted to determine the actual limitations. The Company has concluded that there are no significant uncertain tax positions requiring recognition in the accompanying financial statements. The tax period that is subject to examination by major tax jurisdictions is generally three years from the date of filing.
Recently Issued Accounting Pronouncements Adopted and Not Yet Adopted:	Recently Issued Accounting Pronouncements Adopted and Not Yet Adopted: As of March 31, 2024 and for the 3 months then ended, there were no recently issued accounting standards adopted or not yet adopted which would have a material effect on the Company’s financial statements.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies: (Tables)	3 Months Ended
	Mar. 31, 2024
Summary of Significant Accounting Policies:
Schedule of anti-dilutive securities excluded from calculation	​ ​ ​ ​ ​ ​ ​ ​ For the Three Months Ended ​ March 31, ​ 2024 2023 Common Stock Options 29,674 29,674 Convertible Preferred Stock ​ 46,530 ​ — Common Stock Warrants 287,436 287,197 Total 363,640 316,871

Collaborative Agreements and _2

Collaborative Agreements and Commitments: (Tables)	3 Months Ended
	Mar. 31, 2024
Collaborative Agreements and Commitments:
Summary of activity for the Cannasoul Convertible Notes	Below is a summary of activity for the Cannasoul Convertible Notes as of March 31, 2024: ​ ​ ​ ​ Balance of Cannasoul Convertible Notes as of January 1, 2023 $ — Issued ​ 1,437,598 Change in fair value ​ 902 Balance of Cannasoul Convertible Notes as of December 31, 2023 ​ $ 1,438,500 Issued ​ 500,000 Change in fair value ​ (700) Balance of Cannasoul Convertible Notes as of March 31, 2024 ​ $ 1,937,800

Stock Based Compensation_ (Tabl

Stock Based Compensation: (Tables)	3 Months Ended
	Mar. 31, 2024
Stock Based Compensation:
Summary of stock option activity under the stock option plans	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted- ​ ​ ​ ​ ​ ​ ​ Average ​ Aggregate ​ ​ ​ ​ Weighted- ​ Remaining ​ Intrinsic ​ ​ Number ​ Average ​ Contractual ​ Value ​ ​ of ​ Exercise ​ Term ​ (in ​ ​ Shares ​ Price ​ (Years) ​ millions) Options outstanding at January 1, 2024 29,674 ​ $ 153.75 6.15 ​ $ — Options granted — ​ $ — — ​ — Less options forfeited — ​ $ — — ​ — Less options expired/cancelled — ​ $ — — ​ — Less options exercised — ​ $ — — ​ — Options outstanding at March 31, 2024 29,674 ​ $ 153.75 5.90 ​ $ — Options exercisable at March 31, 2024 26,474 ​ $ 169.75 8.30 ​ $ —

Common Stock Warrants_ (Tables)

Common Stock Warrants: (Tables)	3 Months Ended
	Mar. 31, 2024
Common Stock Warrants:
Schedule of warrants outstanding	​ ​ ​ ​ ​ Number ​ ​ of shares Warrants outstanding January 1, 2023 287,436 Warrants issued — Warrants exercised — Warrants expired ​ — Warrants outstanding and exercisable March 31, 2024 287,436

Fair Value on a Recurring Bas_2

Fair Value on a Recurring Basis (Tables)	3 Months Ended
	Mar. 31, 2024
Fair Value on a Recurring Basis
Schedule of liabilities that are measured at fair value on a recurring basis	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ December 31, Description Level 2024 2023 Liabilities: ​ ​ Warrant liability (Note 6) 3 ​ $ 82,000 ​ $ 140,000 Bifurcated embedded derivative liability (Note 6) 3 ​ $ 141,000 ​ $ 1,113,000
Summary of the change in the fair value of the liabilities that is measured at fair value on a recurring basis	​ ​ ​ ​ ​ ​ March 31, 2024 Balance on December 31, 2022 ​ $ 1,510,000 Change in fair value of warrant liability ​ (1,370,000) Balance on December 31, 2023 ​ $ 140,000 Change in fair value of warrant liability ​ (58,000) Balance on March 31, 2024 ​ $ 82,000 ​ ​ ​ ​ ​ ​ March 31, 2024 Balance on December 31, 2022 ​ $ 369,400 Change in fair value of bifurcated embedded derivative ​ (743,600) Balance on December 31, 2023 ​ $ 1,113,000 Change in fair value of warrant liability ​ (972,000) Balance on March 31, 2024 ​ $ 141,000 ​

Organization, Business, Risks_2

Organization, Business, Risks and Uncertainties: (Details)	Apr. 04, 2024	Mar. 31, 2024 USD ($) $ / shares	Dec. 31, 2023 USD ($) $ / shares	Oct. 24, 2023 D	Apr. 24, 2023 D $ / shares
Common stock, par value (in dollars per share) | $ / shares		$ 0.0001	$ 0.0001
Number of preceding consecutive business failed to maintain minimum closing bid price | D					30
Minimum closing bid price failed to be maintained in the preceding 30 consecutive business days | $ / shares					$ 1
Number of calendar days given as grace period to attain minimum bid price requirement | D				180	180
Cash and cash equivalents | $		$ 26,329,957	$ 28,661,498
Cash and cash equivalents expected amount at financial reporting date | $		$ 25,900,000
Subsequent Event
Reverse Stock Split, conversion ratio	0.04

Summary of Significant Accoun_4

Summary of Significant Accounting Policies: (Details) - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Summary Of Significant Accounting Policies:
Cash balance of insured FDIC amount	$ 400,000
Cash balance of uninsured amount	$ 25,900,000
Lease term	1 year
Total future expense relating to the leases	$ 40,000
Capitalized research and development services	0	$ 0
Net operating loss carryforwards	95,900,000
Net operating loss carryforward	$ 30,600,000
Maximum
Summary Of Significant Accounting Policies:
Estimated useful life (years)	10 years
Minimum
Summary Of Significant Accounting Policies:
Estimated useful life (years)	3 years

Summary of Significant Accoun_5

Summary of Significant Accounting Policies: - Anti-dilutive Securities (Details) - shares	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Summary of Significant Accounting Policies:
Antidilutive securities	363,640	316,871
Employee Stock Option
Summary of Significant Accounting Policies:
Antidilutive securities	29,674	29,674
Convertible Preferred Stock
Summary of Significant Accounting Policies:
Antidilutive securities	46,530
Common Stock Warrants
Summary of Significant Accounting Policies:
Antidilutive securities	287,436	287,197

Collaborative Agreements and _3

Collaborative Agreements and Commitments: (Details)

1 Months Ended

3 Months Ended

12 Months Ended

Oct. 31, 2023 USD ($) item $ / shares shares

Feb. 23, 2023 USD ($)

May 08, 2021 USD ($)

Jun. 09, 2020 USD ($)

Jan. 19, 2017 USD ($)

Jul. 14, 2014 USD ($)

May 12, 2014 USD ($)

Jan. 31, 2024 USD ($)

Mar. 31, 2024 USD ($) agreement

Dec. 31, 2022 agreement

Dec. 31, 2021 agreement

Dec. 31, 2023 USD ($)

Collaborative Agreements and Commitments:

Accrued liability for installment payment

$ 6,015,115

$ 3,395,945

Purchase of Convertible Notes

500,000

Loss from equity method investment

(8,600)

Stanford License Agreements

Collaborative Agreements and Commitments:

Royalty payment percentage

3%

Payments for royalties

0

Commitment to pay additional fee

$ 2,100,000

Estimated cost

1,500,000

Mt. Sinai License Agreement

Collaborative Agreements and Commitments:

Milestone payments made

0

Payments for royalties

0

Additional milestone payments

$ 1,500,000

Total amount paid

200,000

Licensing fees

125,000

Development costs and patent fees

75,000

Payable of milestone payments

$ 2,000,000

Mt. Sinai License Agreement | Net sales up to $250 million

Collaborative Agreements and Commitments:

Royalty payment percentage

2%

Threshold net sales

$ 250,000,000

Mt. Sinai License Agreement | Net sales over $250 million

Collaborative Agreements and Commitments:

Royalty payment percentage

3%

Threshold net sales

$ 250,000,000

Agreements with BryoLogyx

Collaborative Agreements and Commitments:

Percentage of gross revenue

2%

Other income

0

Nemours Agreement

Collaborative Agreements and Commitments:

Estimated cost

$ 2,000,000

Cumulative expenses incurred

100,000

Cleveland Clinic

Collaborative Agreements and Commitments:

Total amount paid

375,000

Estimated cost

$ 2,000,000

Strategic Investment in Debt and Equity Securities of Cannasoul

Collaborative Agreements and Commitments:

Loss from equity method investment

$ 8,600

Cognitive Research Enterprises, Inc

Collaborative Agreements and Commitments:

Number of statements of work agreements entered | agreement

0

0

0

Convertible Note | Strategic Investment in Debt and Equity Securities of Cannasoul

Collaborative Agreements and Commitments:

Number of shares acquired | shares

12,737

Percentage of issued and outstanding share capital

5%

Price per share acquired in an equity method investment | $ / shares

$ 44.1550

Purchase of strategic investment

$ 562,402

Purchase of Convertible Notes

$ 1,437,598

$ 500,000

Number of equity instruments | shares

32,648

Purchase of maximum number of notes | item

4

Maximum amount of investment in aggregate notes receivable

$ 2,000,000

Maximum amount of investment in each notes receivable

$ 500,000

Right to appoint and dismiss number of members in board of directors | item

3

Number of members in board of directors | item

7

License | Stanford License Agreements

Collaborative Agreements and Commitments:

Aggregate amount paid

70,000

Annual license maintenance fee

$ 10,000

Minimum | Mt. Sinai License Agreement

Collaborative Agreements and Commitments:

Royalty payment percentage

1.50%

Maximum | Stanford License Agreements

Collaborative Agreements and Commitments:

Royalty payment percentage

4.50%

Milestone payments made

$ 3,700,000

Maximum | Agreements with BryoLogyx

Collaborative Agreements and Commitments:

Payments for royalties

$ 1,000,000

Collaborative Agreements and _4

Collaborative Agreements and Commitments: - Summary of activity for the Notes (Details) - Convertible Note - Strategic Investment in Debt and Equity Securities of Cannasoul - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Collaborative Agreements and Commitments:
Balance of Initial Convertible Note	$ 1,438,500
Issued	500,000	$ 1,437,598
Change in fair value	(700)	902
Balance of Initial Convertible Note	$ 1,937,800	$ 1,438,500

Related Party Transactions_ (De

Related Party Transactions: (Details) - Consulting Agreement with SM Capital Management, LLC - USD ($)		3 Months Ended
	Aug. 04, 2016	Mar. 31, 2024	Mar. 31, 2023
Related Party Transactions:
Contract payments, term	1 year
Annual consulting fee	$ 120,000
Monthly installment of annual consulting fee	$ 10,000
Consultancy fees		$ 30,000	$ 30,000

Other Commitments_ (Details)

Other Commitments: (Details)				1 Months Ended	3 Months Ended
	May 12, 2022 item	Feb. 10, 2022 USD ($)	Jul. 23, 2020 USD ($)	Apr. 30, 2020 USD ($)	Mar. 31, 2024 USD ($)	Mar. 31, 2023 USD ($)	Jan. 22, 2022 USD ($)	Apr. 30, 2021 USD ($)	Dec. 07, 2020 USD ($)
Other Commitments:
Clinical trial expenses					$ 609,249	$ 877,717
2020 Services Agreement
Other Commitments:
Amount funded against the total trial cost		$ 1,000,000					$ 1,400,000
Total estimated budget for the services					11,000,000
Revised estimated budget for services			$ 9,300,000
Clinical trial expenses					0	300,000
Charges Incurred		$ 0
2020 Services Agreement | National Institutes of Health
Other Commitments:
Total estimated budget for the services			8,300,000
Amount of award received			$ 2,700,000
Funding received				$ 1,000,000
Funding receivable in year two								$ 1,700,000
Clinical trial expenses					11,200,000
Clinical trial expenses incurred					11,200,000
2022 Services Agreement
Other Commitments:
Target enrollment of study subjects | item	12
Total estimated budget for the services					2,000,000
Clinical trial expenses					0	$ 124,000
2022 Services Agreement | National Institutes of Health
Other Commitments:
Clinical trial expenses					1,600,000
Clinical trial expenses incurred					$ 1,600,000
Employment agreement with Alan J. Tuchman, M.D
Other Commitments:
Initial annual base salary									$ 222,000
Annual discretionary bonus payable (as a percent)									50%

Stockholders' Equity_ (Details)

Stockholders' Equity: (Details)	3 Months Ended
	Mar. 31, 2024 Vote $ / shares shares	Dec. 31, 2023 $ / shares shares
Stockholders' Equity:
Common stock, shares authorized	150,000,000	150,000,000
Preferred stock, shares authorized	1,000,000	1,000,000
Preferred stock, par value (in dollars per share) | $ / shares	$ 0.0001	$ 0.0001
Votes per share of common stock | Vote	1

Stockholders' Equity_ - Additio

Stockholders' Equity: - Additional Information (Details)							3 Months Ended		12 Months Ended
	May 13, 2024 shares	Apr. 04, 2024 $ / shares shares	Dec. 20, 2023	May 11, 2023	Mar. 17, 2023 USD ($) $ / shares	Nov. 17, 2022 USD ($) Y $ / shares installment D item shares	Mar. 31, 2024 USD ($) Y $ / shares shares	Mar. 31, 2023 USD ($)	Dec. 31, 2023 USD ($) Y $ / shares	Dec. 31, 2022 USD ($)
Stockholders' Equity:
Series B Preferred Stock, face value per share | $ / shares							$ 1,000		$ 1,000
Weighted-average exercise price of warrants (in $ per share) | $ / shares							$ 296.57
Fair value of warrants							$ 82,000		$ 140,000
Change in fair value of derivative liability							972,000	$ 225,800
Gain on change in fair value of the warrant liability							(58,000)	(588,000)
Accrued liability for installment payment							6,015,115	3,395,945
Redemption of accrued dividends							2,455,656
Subsequent Event
Stockholders' Equity:
Common stock | shares	147,896
Reverse Stock Split, conversion ratio		0.04
Minimum
Stockholders' Equity:
Reverse Stock Split, conversion ratio			0.125
Maximum
Stockholders' Equity:
Reverse Stock Split, conversion ratio			0.04
Series B Preferred Stock
Stockholders' Equity:
Additional paid-in capital to accrete the preferred shares to redemption value							$ 2,455,656
Redeemed series B preferred stock
Stockholders' Equity:
Shares redeemed | shares							3,000,000
Redemption of accrued dividends							$ 87,500
Common stock shares issued | shares							106,126
Discount relieved							$ 2,455,656
Deemed dividends relating to true up conversion of shares in excess of pre-amortization installment amounts							130,959
Preferred Stock
Stockholders' Equity:
Redemption of accrued dividends							(2,455,656)
November 2022 Private Placement
Stockholders' Equity:
Number of Series B Preferred Stock issued | shares						15,000
Series B Preferred Stock, face value per share | $ / shares						$ 1,000
Preferred shares issuable upon conversion of Series B Preferred Stock | shares						77,420
Preferred Stock, conversion price per share | $ / shares						$ 193.75
Warrants to purchase shares of common stock | shares						77,420
Number of equal monthly installments to redeem Series B Preferred Stock | installment						15
Percentage of discount on average closing share prices considered for determination of amortization payments						15%
Number of lowest closing share prices considered for determination of amortization payments | item						3
Trading day period considered for determination of amortization payments						30 days
Percentage of minimum price, considered for determination of amortization payments						20%
Series B Preferred Stock, Stock price trigger for conversion | $ / shares						$ 290.625
Series B Preferred Stock, Threshold Consecutive trading days considered for conversion | D						20
Series B Preferred Stock, Daily trading volume of the Common Stock trigger for conversion | shares						4,000
Series B Preferred Stock, dividend rate						7%
Series B Preferred Stock, dividend rate during the continuance of a Triggering Event						15%
Weighted-average exercise price of warrants (in $ per share) | $ / shares						$ 193.75
Term of warrants						5 years
Issuance date fair value of the associated embedded derivative							141,000
Fair value of warrants							82,000		$ 9,900,000
Warrant Issuance Costs							900,000
Gain on change in fair value of the warrant liability							$ 58,000	$ 588,000
November 2022 Private Placement | Minimum
Stockholders' Equity:
Per share value of Common stock, considered for determination of amortization payments | $ / shares						$ 31.25
November 2022 Private Placement | Maximum
Stockholders' Equity:
Per share value of Common stock, considered for determination of amortization payments | $ / shares						4.30
November 2022 Private Placement | Placement Agents
Stockholders' Equity:
Weighted-average exercise price of warrants (in $ per share) | $ / shares						$ 193.75
Term of warrants						5 years
Percentage of offering fees in cash						7%
Percentage of offering fees in warrants						3%
November 2022 Private Placement | November Purchase Agreement | Subsequent Event
Stockholders' Equity:
Preferred Stock, conversion price per share | $ / shares		$ 4.4437
Warrants to purchase shares of common stock | shares		3,318,586
Weighted-average exercise price of warrants (in $ per share) | $ / shares		$ 4.4437
November 2022 Private Placement | Dividend Rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							0.07
Warrants, measurement input									0
November 2022 Private Placement | Expected term
Stockholders' Equity:
Bifurcated embedded derivative, measurement input | Y							0.42
Warrants, measurement input | Y							3.63		5
November 2022 Private Placement | Risk-free interest rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							0.062
Warrants, measurement input							0.0434		0.0397
November 2022 Private Placement | Fair value of our common stock
Stockholders' Equity:
Bifurcated embedded derivative, measurement input | $ / shares							4.75
November 2022 Private Placement | Estimated equity volatility
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							1.20
Warrants, measurement input							1.20		1.05
November 2022 Private Placement | Estimated traded volume volatility
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							2.15
November 2022 Private Placement | Penalty dividend rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							0.150
November 2022 Private Placement | Probability of default
Stockholders' Equity:
Bifurcated embedded derivative, measurement input							0.021
Warrants, measurement input							0
November 2022 Private Placement | Series B Preferred Stock
Stockholders' Equity:
Percentage of common stock shares, agreed to register under the November registration rights agreement						200%
Issuance date fair value of the associated embedded derivative						$ 2,200,000				$ 2,200,000
Total discount upon issuance of Preferred Shares										12,300,000
Stock issuance costs										500,000
Fair value of warrants										$ 9,600,000
Percentage of preferred share floor price					20%
Percentage of changes in fair value convertible preferred stock				0.05%	34%
Increase in fair value of deemed dividend on preferred stock					$ 5,700,000
November 2022 Private Placement | Series B Preferred Stock | Minimum
Stockholders' Equity:
Floor price | $ / shares					$ 31.25
November 2022 Private Placement | Series B Preferred Stock | Maximum
Stockholders' Equity:
Percentage of changes in fair value convertible preferred stock				10%	10%
November 2022 Private Placement | Series B Preferred Stock | Dividend Rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						0.07
November 2022 Private Placement | Series B Preferred Stock | Expected term
Stockholders' Equity:
Bifurcated embedded derivative, measurement input | Y						1.61
November 2022 Private Placement | Series B Preferred Stock | Risk-free interest rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						0.073
November 2022 Private Placement | Series B Preferred Stock | Fair value of our common stock
Stockholders' Equity:
Bifurcated embedded derivative, measurement input | $ / shares						163
November 2022 Private Placement | Series B Preferred Stock | Estimated equity volatility
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						0.850
November 2022 Private Placement | Series B Preferred Stock | Estimated traded volume volatility
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						2.550
November 2022 Private Placement | Series B Preferred Stock | Penalty dividend rate
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						0.150
November 2022 Private Placement | Series B Preferred Stock | Probability of default
Stockholders' Equity:
Bifurcated embedded derivative, measurement input						0.082

Stock Based Compensation_ (Deta

Stock Based Compensation: (Details)							3 Months Ended
	Apr. 08, 2024 USD ($) director $ / shares shares	Mar. 07, 2024 USD ($) shares	Jan. 08, 2024 USD ($) shares	Mar. 29, 2023 shares	Mar. 22, 2023 USD ($) shares	Jan. 05, 2023 USD ($) shares	Mar. 31, 2024 USD ($) $ / shares	Mar. 31, 2023 USD ($)	Dec. 31, 2023 USD ($) $ / shares	Dec. 20, 2023 shares	Dec. 19, 2023 shares
Stock Based Compensation:
Closing stock price (in $ per share) | $ / shares							$ 4.70		$ 6.80
Unrecognized stock option expense							$ 0
Unrecognized stock option expense - Weighted average period of recognition (in years)							0 years
Fair value of stock options							$ 0		$ 0
Total stock-based compensation expense							14,407	$ 644,781
Research And Development
Stock Based Compensation:
Total stock-based compensation expense							0	99,726
General And Administrative
Stock Based Compensation:
Total stock-based compensation expense							$ 14,407	$ 545,055
Restricted Stock | Consulting Agreement With Sherwood Ventures LLC
Stock Based Compensation:
Number of shares issued (in shares) | shares			14,641		180	3,533
Fair market value of shares issued			$ 100,000		$ 4,500	$ 100,000
Restricted Stock | Consulting Agreement With Neil Cataldi
Stock Based Compensation:
Number of shares issued (in shares) | shares		981
Fair market value of shares issued		$ 4,500
Equity Incentive Plan 2020
Stock Based Compensation:
Number of shares of common stock authorized for issuance (in shares) | shares										175,000	55,000
Director Compensation Policy | Non employee directors
Stock Based Compensation:
Option vesting period (in years)				1 year
Number of securities available for grant (in shares) | shares				800
Director Compensation Policy | Non employee directors | Subsequent Event
Stock Based Compensation:
Number of directors to whom stock options were granted | director	4
Number of options granted (in shares) | shares	3,200
Option Exercise Price (in $ per share) | $ / shares	$ 5.39
Option expiration period (in years)	10 years
Option vesting period (in years)	1 year
Option Implied Volatility (in %)	124.35%
Option Risk-free interest rate (in %)	4.43%
Fair value of stock options	$ 18,601
Director Compensation Policy | Newly appointed director
Stock Based Compensation:
Number of securities available for grant (in shares) | shares				800
Option Vesting percentage (in %)				50%
Director Compensation Policy | Newly appointed director | First anniversary from Start Date
Stock Based Compensation:
Option Vesting percentage (in %)				25%
Director Compensation Policy | Newly appointed director | Second anniversary from Start Date
Stock Based Compensation:
Option Vesting percentage (in %)				25%

Stock Based Compensation_ - Sto

Stock Based Compensation: - Stock option activity under the stock option plans (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Number of Shares
Options outstanding at the beginning	29,674
Options outstanding at the end	29,674	29,674
Options exercisable at the end	26,474
Weighted-Average Exercise Price
Options outstanding at the beginning (in dollars per share)	$ 153.75
Options outstanding at the end (in dollars per share)	153.75	$ 153.75
Options exercisable at the end (in dollars per share)	$ 169.75
Weighted-Average Remaining Contractual Term (Years)
Options outstanding at the end (in years)	5 years 10 months 24 days	6 years 1 month 24 days
Options exercisable at the end (in years)	8 years 3 months 18 days
Aggregate Intrinsic Value (in millions)
Options outstanding at the beginning (in dollars)	$ 0
Options outstanding at the end (in dollars)	0	$ 0
Options exercisable at the end (in dollars)	$ 0

Common Stock Warrants_ - Common

Common Stock Warrants: - Common stock warrant outstanding (Details)	3 Months Ended
	Mar. 31, 2024 shares
Common Stock Warrants:
Warrants outstanding January 1, 2023	287,436
Warrants issued	0
Warrants exercised	0
Warrants expired	0
Warrants outstanding and exercisable March 31, 2024	287,436

Common Stock Warrants_ - Additi

Common Stock Warrants: - Additional Information (Details) - USD ($)	3 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Common Stock Warrants:
Weighted-average exercise price of warrants (in $ per share)	$ 296.57
Weighted-average remaining life of total warrants (in years)	2 years 4 months 28 days
Intrinsic value of the warrants	$ 24,000
Closing stock price (in $ per share)	$ 4.70	$ 6.80

Fair Value on a Recurring Bas_3

Fair Value on a Recurring Basis - Fair value hierarchy of the valuation inputs (Details) - Recurring - Fair Value, Inputs, Level 3 - USD ($)	Mar. 31, 2024	Dec. 31, 2023
Warrant liability
Liabilities:
Liabilities, fair value	$ 82,000	$ 140,000
Bifurcated embedded derivative liability
Liabilities:
Liabilities, fair value	$ 141,000	$ 1,113,000

Fair Value on a Recurring Bas_4

Fair Value on a Recurring Basis - Change in the fair value (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2024	Dec. 31, 2023
Warrant liability
Change in the fair value of the liability
Beginning balance	$ 140,000	$ 1,510,000
Change in fair value of warrant liability	(58,000)	(1,370,000)
Ending balance	82,000	140,000
Bifurcated embedded derivative liability
Change in the fair value of the liability
Beginning balance	1,113,000	369,400
Change in fair value of warrant liability	(972,000)	(743,600)
Ending balance	$ 141,000	$ 1,113,000

Pay vs Performance Disclosure

Pay vs Performance Disclosure - USD ($)	3 Months Ended
	Mar. 31, 2024	Mar. 31, 2023
Pay vs Performance Disclosure
Net Income (Loss)	$ (206,699)	$ (1,711,784)

Insider Trading Arrangements

Insider Trading Arrangements	3 Months Ended
	Mar. 31, 2024
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Non-Rule 10b5-1 Arrangement Terminated	false
Rule 10b5-1 Arrangement Modified	false
Non-Rule 10b5-1 Arrangement Modified	false