Cover Page
Cover Page - shares | 6 Months Ended | |
Jun. 30, 2020 | Aug. 03, 2020 | |
Cover [Abstract] | ||
Entity Central Index Key | 0001576263 | |
Amendment Flag | false | |
Current Fiscal Year End Date | --12-31 | |
Document Fiscal Year Focus | 2020 | |
Document Fiscal Period Focus | Q2 | |
Document Type | 10-Q | |
Document Quarterly Report | true | |
Document Period End Date | Jun. 30, 2020 | |
Document Transition Report | false | |
Entity File Number | 001-35921 | |
Entity Registrant Name | Mirati Therapeutics, Inc. | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 46-2693615 | |
Entity Address, Address Line One | 9393 Towne Centre Drive, Suite 200 | |
Entity Address, City or Town | San Diego | |
Entity Address, State or Province | CA | |
Entity Address, Postal Zip Code | 92121 | |
City Area Code | 858 | |
Local Phone Number | 332-3410 | |
Title of 12(b) Security | Common Stock, par value $0.001 per share | |
Trading Symbol | MRTX | |
Security Exchange Name | NASDAQ | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Large Accelerated Filer | |
Entity Small Business | false | |
Entity Emerging Growth Company | false | |
Entity Shell Company | false | |
Entity Common Stock, Shares Outstanding | 44,540,693 |
CONDENSED CONSOLIDATED BALANCE
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Current assets | ||
Cash and cash equivalents | $ 131,689 | $ 46,535 |
Short-term investments | 514,021 | 368,515 |
Other current assets | 8,327 | 9,357 |
Total current assets | 654,037 | 424,407 |
Property and equipment, net | 3,187 | 1,776 |
Other long-term assets | 6,726 | 6,017 |
Total assets | 663,950 | 432,200 |
Current liabilities | ||
Accounts payable and accrued liabilities | 56,843 | 48,082 |
Deferred revenue and other current liabilities | 852 | 824 |
Total current liabilities | 57,695 | 48,906 |
Other long-term liabilities | 1,251 | 999 |
Total liabilities | 58,946 | 49,905 |
Commitments and contingencies (see Note 11) | ||
Shareholders’ equity | ||
Preferred stock, $0.001 par value; 10,000,000 shares authorized; none issued and outstanding at both June 30, 2020 and December 31, 2019 | 0 | 0 |
Common stock, $0.001 par value; 100,000,000 shares authorized; 44,482,308 and 39,517,329 issued and outstanding at June 30, 2020 and December 31, 2019, respectively | 45 | 40 |
Additional paid-in capital | 1,535,490 | 1,144,667 |
Accumulated other comprehensive income | 11,284 | 9,889 |
Accumulated deficit | (941,815) | (772,301) |
Total shareholders’ equity | 605,004 | 382,295 |
Total liabilities and shareholders’ equity | $ 663,950 | $ 432,200 |
CONDENSED CONSOLIDATED BALANC_2
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares | Jun. 30, 2020 | Dec. 31, 2019 |
Statement of Financial Position [Abstract] | ||
Preferred stock, par value (USD per share) | $ 0.001 | $ 0.001 |
Preferred stock authorized (shares) | 10,000,000 | 10,000,000 |
Preferred stock issued (shares) | 0 | 0 |
Preferred stock outstanding (shares) | 0 | 0 |
Common stock, par value (USD per share) | $ 0.001 | $ 0.001 |
Common stock authorized (shares) | 100,000,000 | 100,000,000 |
Common stock issued (shares) | 44,482,308 | 39,517,329 |
Common stock outstanding (shares) | 44,482,308 | 39,517,329 |
CONDENSED CONSOLIDATED STATEMEN
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Revenue | ||||
License and collaboration revenues | $ 0 | $ 577 | $ 267 | $ 1,821 |
Total revenue | 0 | 577 | 267 | 1,821 |
Operating expenses | ||||
Research and development | 65,083 | 38,324 | 136,791 | 72,564 |
General and administrative | 19,779 | 9,894 | 37,825 | 19,656 |
Total operating expenses | 84,862 | 48,218 | 174,616 | 92,220 |
Loss from operations | (84,862) | (47,641) | (174,349) | (90,399) |
Other income, net | 2,003 | 1,946 | 4,835 | 3,792 |
Net loss | (82,859) | (45,695) | (169,514) | (86,607) |
Unrealized gain on available-for-sale investments | 1,577 | 151 | 1,395 | 309 |
Comprehensive loss | $ (81,282) | $ (45,544) | $ (168,119) | $ (86,298) |
Basic and diluted net loss per share (USD per share) | $ (1.89) | $ (1.26) | $ (3.91) | $ (2.43) |
Weighted average number of shares used in computing net loss per share, basic and diluted (shares) | 43,825,723 | 36,173,605 | 43,356,207 | 35,580,279 |
CONDENSED CONSOLIDATED STATEM_2
CONDENSED CONSOLIDATED STATEMENTS OF CHANGES IN STOCKHOLDERS' EQUITY - USD ($) $ in Thousands | Total | Common Stock | Additional paid-in capital | Accumulated other comprehensive income | Accumulated deficit |
Balance at beginning of period (shares) at Dec. 31, 2018 | 32,538,857 | ||||
Balance at beginning of period at Dec. 31, 2018 | $ 201,576 | $ 33 | $ 751,109 | $ 9,479 | $ (559,045) |
Increase (Decrease) in Stockholders' Equity | |||||
Net loss for the period | (86,607) | (86,607) | |||
Issuance of common stock, net of issuance costs (shares) | 4,269,838 | ||||
Issuance of common stock, net of issuance costs | 327,810 | $ 5 | 327,805 | ||
Share-based compensation expense | 23,720 | 23,720 | |||
Issuance of common stock from ESPP (shares) | 9,844 | ||||
Issuance of common stock from ESPP | 323 | 323 | |||
Issuance of common stock under equity incentive plans (shares) | 332,887 | ||||
Issuance of common stock under equity incentive plans | $ 4,300 | 4,300 | |||
Net exercise of warrants (shares) | 1,400,000 | 1,400,000 | |||
Net exercise of warrants | $ 1 | (1) | |||
Proceeds from disgorgement of shareholders' short-swing profits | $ 1,050 | 1,050 | |||
Unrealized gain (loss) on investments | 309 | 309 | |||
Balance at end of period (shares) at Jun. 30, 2019 | 38,551,426 | ||||
Balance at end of period at Jun. 30, 2019 | 472,481 | $ 39 | 1,108,306 | 9,788 | (645,652) |
Balance at beginning of period (shares) at Mar. 31, 2019 | 36,029,093 | ||||
Balance at beginning of period at Mar. 31, 2019 | 283,554 | $ 36 | 873,838 | 9,637 | (599,957) |
Increase (Decrease) in Stockholders' Equity | |||||
Net loss for the period | (45,695) | (45,695) | |||
Issuance of common stock, net of issuance costs (shares) | 2,415,000 | ||||
Issuance of common stock, net of issuance costs | 219,927 | $ 3 | 219,924 | ||
Share-based compensation expense | 12,589 | 12,589 | |||
Issuance of common stock from ESPP (shares) | 9,844 | ||||
Issuance of common stock from ESPP | 323 | 323 | |||
Issuance of common stock under equity incentive plans (shares) | 97,489 | ||||
Issuance of common stock under equity incentive plans | 1,632 | 1,632 | |||
Unrealized gain (loss) on investments | 151 | 151 | |||
Balance at end of period (shares) at Jun. 30, 2019 | 38,551,426 | ||||
Balance at end of period at Jun. 30, 2019 | $ 472,481 | $ 39 | 1,108,306 | 9,788 | (645,652) |
Balance at beginning of period (shares) at Dec. 31, 2019 | 39,517,329 | 39,517,329 | |||
Balance at beginning of period at Dec. 31, 2019 | $ 382,295 | $ 40 | 1,144,667 | 9,889 | (772,301) |
Increase (Decrease) in Stockholders' Equity | |||||
Net loss for the period | (169,514) | (169,514) | |||
Issuance of common stock, net of issuance costs (shares) | 3,538,462 | ||||
Issuance of common stock, net of issuance costs | 323,977 | $ 4 | 323,973 | ||
Share-based compensation expense | 42,354 | 42,354 | |||
Issuance of common stock from ESPP (shares) | 6,207 | ||||
Issuance of common stock from ESPP | 524 | 524 | |||
Issuance of common stock under equity incentive plans (shares) | 820,310 | ||||
Issuance of common stock under equity incentive plans | $ 23,932 | 23,932 | |||
Net exercise of warrants (shares) | 600,000 | 600,000 | |||
Net exercise of warrants | $ 1 | (1) | |||
Proceeds from disgorgement of shareholders' short-swing profits | $ 41 | 41 | |||
Unrealized gain (loss) on investments | $ 1,395 | 1,395 | |||
Balance at end of period (shares) at Jun. 30, 2020 | 44,482,308 | 44,482,308 | |||
Balance at end of period at Jun. 30, 2020 | $ 605,004 | $ 45 | 1,535,490 | 11,284 | (941,815) |
Balance at beginning of period (shares) at Mar. 31, 2020 | 43,552,312 | ||||
Balance at beginning of period at Mar. 31, 2020 | 656,226 | $ 44 | 1,505,431 | 9,707 | (858,956) |
Increase (Decrease) in Stockholders' Equity | |||||
Net loss for the period | (82,859) | (82,859) | |||
Share-based compensation expense | 20,787 | 20,787 | |||
Issuance of common stock from ESPP (shares) | 6,207 | ||||
Issuance of common stock from ESPP | 524 | 524 | |||
Issuance of common stock under equity incentive plans (shares) | 323,789 | ||||
Issuance of common stock under equity incentive plans | $ 8,749 | 8,749 | |||
Net exercise of warrants (shares) | 600,000 | 600,000 | |||
Net exercise of warrants | $ 1 | (1) | |||
Unrealized gain (loss) on investments | $ 1,577 | 1,577 | |||
Balance at end of period (shares) at Jun. 30, 2020 | 44,482,308 | 44,482,308 | |||
Balance at end of period at Jun. 30, 2020 | $ 605,004 | $ 45 | $ 1,535,490 | $ 11,284 | $ (941,815) |
CONDENSED CONSOLIDATED STATEM_3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2020 | Jun. 30, 2019 | |
Operating activities: | ||
Net loss | $ (169,514) | $ (86,607) |
Non-cash adjustments reconciling net loss to operating cash flows: | ||
Depreciation of property and equipment | 253 | 99 |
Accretion of discount on investments | (863) | (1,964) |
Share-based compensation expense | 42,354 | 23,720 |
Changes in operating assets and liabilities: | ||
Other current assets | 1,029 | (6,313) |
Other long-term assets | (409) | (3,982) |
Accounts payable, accrued liabilities, deferred revenue and other liabilities | 8,803 | 2,097 |
Cash flows used in operating activities | (118,347) | (72,950) |
Investing activities: | ||
Purchases of short-term investments | (384,127) | (212,666) |
Sales and maturities of short-term investments | 240,878 | 171,600 |
Purchases of property, plant, and equipment | (1,425) | (69) |
Cash flows used in investing activities | (144,674) | (41,135) |
Financing activities: | ||
Proceeds from issuance of common stock, net of issuance costs | 323,977 | 327,810 |
Proceeds from issuance of common stock under equity incentive plans | 23,932 | 4,300 |
Proceeds from disgorgement of shareholders' short-swing profits | 41 | 1,050 |
Proceeds from stock issuances under employee stock purchase plan | 524 | 323 |
Cash flows provided by financing activities | 348,474 | 333,483 |
Increase in cash, cash equivalents and restricted cash | 85,453 | 219,398 |
Cash, cash equivalents and restricted cash, beginning of period | 46,856 | 32,694 |
Cash, cash equivalents and restricted cash, end of period | 132,309 | 252,092 |
Reconciliation of cash, cash equivalents and restricted cash, end of period: | ||
Total cash, cash equivalents and restricted cash | 132,309 | 252,092 |
Supplemental disclosures of non-cash investing activities: | ||
Purchases of property, plant, and equipment included within accounts payable and accrued liabilities | $ 239 | $ 0 |
Description of Business
Description of Business | 6 Months Ended |
Jun. 30, 2020 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Description of Business | Description of Business Mirati Therapeutics, Inc. ("Mirati" or the "Company") is a clinical-stage oncology company developing product candidates to address the genetic and immunological promoters of cancer. The Company was incorporated under the laws of the State of Delaware on April 29, 2013 as Mirati Therapeutics, Inc. and is located in San Diego, California. The Company has a wholly owned subsidiary in Canada, MethylGene, Inc., and operates in one |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | Summary of Significant Accounting Policies Basis of Presentation The unaudited condensed consolidated financial statements contained in this Quarterly Report on Form 10-Q have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission ("SEC") and, therefore, certain information and disclosures normally included in annual financial statements prepared in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP") have been omitted. In the opinion of management, the information reflects all adjustments necessary to make the results of operations for the interim periods a fair statement of such operations. All such adjustments are of a normal recurring nature. Interim results are not necessarily indicative of results for the full year. The condensed consolidated balance sheet at December 31, 2019 has been derived from the audited consolidated financial statements at that date, but does not include all information and footnotes required by U.S. GAAP for complete financial statements. These unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2019 . Use of Estimates The preparation of the Company's unaudited condensed consolidated financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period. Reported amounts and note disclosures reflect the overall economic conditions that are most likely to occur and anticipated measures management intends to take. Actual results could differ materially from those estimates. Estimates and assumptions are reviewed quarterly. Any revisions to accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected. Cash, Cash Equivalents and Short-term Investments Cash and cash equivalents consist of cash and highly liquid securities with original maturities at the date of acquisition of ninety days or less. Investments with an original maturity of more than ninety days are considered short-term investments and have been classified by management as available-for-sale. These investments are classified as current assets, even though the stated maturity date may be one year or more beyond the current balance sheet date, which reflects management’s intention to use the proceeds from sales of these securities to fund its operations, as necessary. Such investments are carried at fair value, and the unrealized gains and losses are reported as a component of accumulated other comprehensive income in shareholders’ equity until realized. Realized gains and losses from the sale of available-for-sale securities, if any, are determined on a specific identification basis. Concentration of Credit Risk The Company invests its excess cash in accordance with its investment policy. The Company's investments are comprised primarily of commercial paper and debt instruments of financial institutions, corporations, U.S. government-sponsored agencies and the U.S. Treasury. The Company mitigates credit risk by maintaining a diversified portfolio and limiting the amount of investment exposure as to institution, maturity and investment type. Financial instruments that potentially subject the Company to significant credit risk consist principally of cash equivalents and short-term investments. Revenue Recognition The Company recognizes revenue in connection with a collaboration and license agreement in accordance with the guidance of Revenue From Contracts With Customers, Accounting Standards Codification ("ASC") Topic 606 ("Topic 606"). Under Topic 606, the Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements the Company determines are within the scope of Topic 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that the Company will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Net Loss per Share Basic net loss per common share is calculated by dividing net loss by the weighted-average number of common shares outstanding during the period, without consideration for common share equivalents as they are anti-dilutive. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of common shares and common share equivalents outstanding for the period. Common share equivalents outstanding, determined using the treasury stock method, are comprised of shares that may be issued under the Company’s stock option and warrant agreements. The following table presents the weighted-average number of common share equivalents, calculated using the treasury stock method, not included in the calculation of diluted net loss per share due to the anti-dilutive effect of the securities: Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Common stock options 2,112,690 2,371,908 2,145,789 2,347,335 Common stock warrants 9,623,913 10,417,753 9,658,342 10,710,055 Total 11,736,603 12,789,661 11,804,131 13,057,390 |
Recently Adopted and Recently I
Recently Adopted and Recently Issued Accounting Pronouncements | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Recently Adopted and Recently Issued Accounting Pronouncements | Recently Adopted and Recently Issued Accounting Pronouncements From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board ("FASB") or other standard setting bodies that are adopted by the Company as of the specified effective date. Recently Adopted Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update ("ASU") 2016-13, Financial Instruments-Credit Losses: Measurement of Credit Losses on Financial Instruments , which changes the impairment model for most financial assets and certain other instruments. For trade receivables and other instruments, entities are required to use a new forward-looking expected loss model that generally results in the earlier recognition of allowances for losses. For available-for-sale debt securities with unrealized losses, the losses are recognized as allowances rather than as reductions in the amortized cost of the securities. This guidance is effective for annual reporting periods beginning after December 15, 2019, including interim periods within those years. Effective January 1, 2020, the Company adopted the provisions of ASU 2016-13. The adoption did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework - Changes to the Disclosure Requirements for Fair Value Measurement . The new guidance modifies the disclosure requirements on fair value measurements in Topic 820. The amendments in ASU 2018-13 are effective for all entities for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2019. Effective January 1, 2020, the Company adopted the provisions of ASU 2018-13. The adoption did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes . The update includes removing several exceptions under the existing guidance and includes several simplification updates, none of which apply to the Company's current accounting for income taxes. The guidance is effective for fiscal years beginning after December 15, 2020 and early adoption is permitted. Effective January 1, 2020, the Company early adopted this updated guidance and it did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. |
Short-Term Investments
Short-Term Investments | 6 Months Ended |
Jun. 30, 2020 | |
Investments, Debt and Equity Securities [Abstract] | |
Short-Term Investments | Short-Term Investments The following tables summarize the Company's short-term investments (dollars in thousands): As of June 30, 2020 Maturity Amortized cost Gross unrealized gains Gross unrealized losses Estimated fair value Corporate debt securities 2 years or less $ 177,244 $ 1,044 $ — $ 178,288 Commercial paper 1 year or less 233,296 594 (1 ) 233,889 U.S. Agency bonds 2 years or less 38,308 75 (1 ) 38,382 U.S. Treasury bills 1 year or less 63,411 52 (1 ) 63,462 $ 512,259 $ 1,765 $ (3 ) $ 514,021 As of December 31, 2019 Maturity Amortized cost Gross unrealized gains Gross unrealized losses Estimated fair value Corporate debt securities 2 years or less $ 160,065 $ 233 $ (1 ) $ 160,297 Commercial paper 1 year or less 120,862 74 — 120,936 U.S. Agency bonds 2 years or less 50,745 41 (4 ) 50,782 U.S. Treasury bills 2 years or less 36,474 27 (1 ) 36,500 $ 368,146 $ 375 $ (6 ) $ 368,515 The Company has classified all of its investment securities as available-for-sale as the sale of such securities may be required prior to maturity to implement management strategies, and accordingly, carries these investments at fair value. As of June 30, 2020 , and December 31, 2019 , aggregated gross unrealized losses of available-for-sale investments were not material, and accordingly, no allowance for credit losses was recorded as of June 30, 2020 . |
Fair Value Measurements
Fair Value Measurements | 6 Months Ended |
Jun. 30, 2020 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | Fair Value Measurements The Company has certain financial assets and liabilities recorded at fair value which have been classified as Level 1 or 2 within the fair value hierarchy as described in the accounting standards for fair value measurements. The authoritative guidance for fair value measurements defines fair value as the exchange price that would be received for an asset or paid to transfer a liability (an exit price) in the principal or the most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Market participants are buyers and sellers in the principal market that are (i) independent, (ii) knowledgeable, (iii) able to transact, and (iv) willing to transact. The guidance prioritizes the inputs used in measuring fair value into the following hierarchy: • Level 1- Quoted prices (unadjusted) in active markets for identical assets or liabilities; • Level 2- Inputs other than quoted prices included within Level 1 that are either directly or indirectly observable; and • Level 3- Unobservable inputs in which little or no market activity exists, therefore requiring an entity to develop its own assumptions about the assumptions that market participants would use in pricing. The following tables summarize the assets measured at fair value on a recurring basis (in thousands): June 30, 2020 Total Level 1 Level 2 Assets Cash and cash equivalents: Cash $ 12,198 $ 12,198 $ — Money market funds 119,491 119,491 — Total cash and cash equivalents 131,689 131,689 — Short-term investments: U.S. Treasury bills 63,462 63,462 — Corporate debt securities 178,288 — 178,288 Commercial paper 233,889 — 233,889 U.S. Agency bonds 38,382 — 38,382 Total short-term investments 514,021 63,462 450,559 Total $ 645,710 $ 195,151 $ 450,559 December 31, 2019 Total Level 1 Level 2 Assets Cash and cash equivalents: Cash $ 662 $ 662 $ — Money market funds 45,873 45,873 — Total cash and cash equivalents 46,535 46,535 — Short-term investments: U.S. Treasury bills 36,500 36,500 — Corporate debt securities 160,297 — 160,297 Commercial paper 120,936 — 120,936 U.S. Agency bonds 50,782 — 50,782 Total short-term investments 368,515 36,500 332,015 Total $ 415,050 $ 83,035 $ 332,015 The Company’s investments in Level 1 assets are valued based on publicly available quoted market prices for identical securities as of June 30, 2020 and December 31, 2019 . The Company determines the fair value of Level 2 related securities with the aid of valuations provided by third parties using proprietary valuation models and analytical tools. These valuation models and analytical tools use market pricing or prices for similar instruments that are both objective and publicly available, including matrix pricing or reported trades, benchmark yields, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids and/or offers. There were no transfers between fair value measurement levels during the three and six months ended June 30, 2020 or the year ended December 31, 2019 |
Other Current Assets and Other
Other Current Assets and Other Long-Term Assets | 6 Months Ended |
Jun. 30, 2020 | |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | |
Other Current Assets and Other Long-Term Assets | Other Current Assets and Other Long-Term Assets Other current assets consisted of the following (in thousands): June 30, December 31, 2020 2019 Prepaid expenses $ 5,043 $ 5,672 Deposits and other receivables 1,471 2,119 Interest receivable 1,813 1,566 $ 8,327 $ 9,357 The other long-term assets balance as of June 30, 2020 consisted of $5.4 million in deposits paid in conjunction with the Company's research and development activities, $0.7 million for an operating right-of-use asset for the Company's corporate headquarters, and $0.6 million for a security deposit in connection with the lease of the Company's future corporate headquarters. As of December 31, 2019 , the other long-term assets balance consisted of $5.1 million in deposits paid in conjunction with the Company's research and development activities, $0.6 million for an operating right-of-use asset for the Company's corporate headquarters, and $0.3 million for a security deposit in connection with the lease of the Company's future corporate headquarters. |
Property and Equipment, Net
Property and Equipment, Net | 6 Months Ended |
Jun. 30, 2020 | |
Property, Plant and Equipment [Abstract] | |
Property and Equipment, Net | Property and Equipment, Net Property and equipment consisted of the following (in thousands): June 30, December 31, 2020 2019 Computer equipment $ 201 $ 201 Office and other equipment 329 329 Laboratory equipment 2,791 2,212 Leasehold improvements 63 63 Assets not placed in service 1,085 — Gross property and equipment 4,469 2,805 Less: Accumulated depreciation (1,282 ) (1,029 ) Property and equipment, net $ 3,187 $ 1,776 The Company incurred $0.1 million and immaterial depreciation expense for the three months ended June 30, 2020 and 2019 , and $0.3 million and $0.1 million for the six months ended June 30, 2020 and 2019 , respectively. |
Accounts Payable, Accrued Liabi
Accounts Payable, Accrued Liabilities and Long-Term Liabilities | 6 Months Ended |
Jun. 30, 2020 | |
Payables and Accruals [Abstract] | |
Accounts Payable, Accrued Liabilities and Long-Term Liabilities | Accounts Payable, Accrued Liabilities and Long-Term Liabilities Accounts payable and accrued liabilities consisted of the following (in thousands): June 30, December 31, 2020 2019 Accounts payable $ 24,099 $ 16,367 Accrued clinical expense 22,920 21,290 Accrued development and other expense 4,743 2,510 Accrued compensation and benefits 5,081 7,915 $ 56,843 $ 48,082 The long-term liabilities balance of $1.3 million as of June 30, 2020 , and $1.0 million as of December 31, 2019 |
Collaboration Agreements
Collaboration Agreements | 6 Months Ended |
Jun. 30, 2020 | |
Research and Development [Abstract] | |
Collaboration Agreements | Collaboration Agreements BeiGene Agreement Terms of Agreement On January 7, 2018, the Company and BeiGene Ltd, ("BeiGene") entered into a Collaboration and License Agreement (the “Agreement”), pursuant to which the Company and BeiGene agreed to collaboratively develop sitravatinib in Asia (excluding Japan and certain other countries), Australia and New Zealand (the “Licensed Territory”). Under the Agreement, the Company granted BeiGene an exclusive license to develop, manufacture and commercialize sitravatinib in the Licensed Territory, with the Company retaining exclusive rights for the development, manufacture and commercialization of sitravatinib outside the Licensed Territory. As consideration for the rights granted to BeiGene under the Agreement, BeiGene paid the Company a non-refundable, non-creditable up-front fee of $10.0 million . BeiGene is also required to make milestone payments to the Company of up to an aggregate of $123.0 million upon the first achievement of specified clinical, regulatory and sales milestones. The Agreement additionally provides that BeiGene is obligated to pay to the Company royalties at tiered percentage rates ranging from mid-single digits to twenty percent on annual net sales of licensed products in the Licensed Territory, subject to reduction under specified circumstances. The Agreement also provides that the Company will supply BeiGene with sitravatinib for use in BeiGene’s development activities in the Licensed Territory. The Agreement will terminate upon the expiration of the last royalty term for the licensed products, which is the latest of (i) the date of expiration of the last valid patent claim related to the licensed products under the Agreement, (ii) 10 years after the first commercial sale of a licensed product and (iii) the expiration of any regulatory exclusivity as to a licensed product. BeiGene may terminate the Agreement at any time by providing 60 days prior written notice to the Company. Either party may terminate the Agreement upon a material breach by the other party that remains uncured following 60 days after the date of written notice of such breach or upon certain bankruptcy events. In addition, the Company may terminate the Agreement upon written notice to BeiGene under specified circumstances if BeiGene challenges the licensed patent rights. Revenue Recognition The Company evaluated the Agreement under Topic 606. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under the Agreement, the Company performed the following steps: (i) identified the promised goods or services in the contract; (ii) determined whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measured the transaction price, including any constraints on variable consideration; (iv) allocated the transaction price to the performance obligations; and (v) recognized revenue when (or as) the Company satisfied each performance obligation. The Company determined the transaction price is equal to the up-front fee of $10.0 million . The transaction price was allocated to the performance obligations on the basis of the relative stand-alone selling price estimated for each performance obligation. In estimating the stand-alone selling price for each performance obligation, the Company developed assumptions that require judgment and included forecasted revenues, expected development timelines, discount rates, probabilities of technical and regulatory success and costs for manufacturing clinical supplies. As such, of the up-front fee, the Company allocated $9.5 million to the license to the Company's intellectual property, bundled with the associated know-how, and $0.5 million to the initial obligation to supply sitravatinib for clinical development in the Licensed Territory. Licenses of Intellectual Property. The license to the Company’s intellectual property, bundled with the associated know-how, represents a distinct performance obligation. The license and associated know-how was transferred to BeiGene during the three months ended March 31, 2018, therefore during 2018 the Company recognized the full revenue amount of $9.5 million related to this performance obligation as license and collaboration revenues in its condensed consolidated statements of operations and comprehensive loss; no revenue related to this performance obligation was recorded during the three and six months ended June 30, 2020 or 2019 . Manufacturing Supply Services. The Company's initial obligation to supply sitravatinib for clinical development in the Licensed Territory represents a distinct performance obligation. The Company recognizes revenue when BeiGene obtains control of the goods, upon delivery, over the period of the obligation, which began in late 2018 and will continue into 2020. No revenue related to this performance obligation was recognized for the three months ended June 30, 2020 . The Company recognized $0.6 million as license and collaboration revenues for this performance obligation for the three months ended June 30, 2019 , primarily consisting of cost-sharing payments due from BeiGene. The Company recognized $0.3 million as license and collaboration revenues for this performance obligation for the six months ended June 30, 2020 , primarily consisting of cost-sharing payments due from BeiGene. The Company recognized $1.8 million as license and collaboration revenues for this performance obligation for the six months ended June 30, 2019 , of which $1.6 million relates to cost-sharing payments due from BeiGene and $0.2 million relates to recognition from the deferred revenue balance. Milestone Payments. The Company is entitled to development milestones under the agreement. The next clinical development milestone is for BeiGene initiating the first pivotal clinical trial in the Licensed Territory upon which the Company will be paid a $5.0 million milestone payment. The Company is also entitled to certain regulatory milestone payments which are paid upon receipt of regulatory approvals within the Licensed Territory. No milestone payments were earned during the three and six months ended June 30, 2020 or 2019 . The Company evaluated whether the remaining milestones are considered probable of being reached and determined that their achievement is highly dependent on factors outside of the Company's control. Therefore, these payments have been fully constrained and are not included in the transaction price. At the end of each subsequent reporting period, the Company will re-evaluate the probability of achievement of each milestone and any related constraint, and if necessary, adjust its estimate of the overall transaction price. Any such adjustments are recorded on a cumulative catch-up basis, which would affect the reported amount of license and collaboration revenues in the period of adjustment. Royalties. As the license is deemed to be the predominant item to which sales-based royalties relate, the Company will recognize revenue when the related sales occur. No royalty revenue was recognized during the three and six months ended June 30, 2020 or 2019 . The following table presents a summary of the activity in the Company's contract liabilities during the six months ended June 30, 2020 (in thousands): Opening balance, January 1, 2020 $ (172 ) Revenue from performance obligations satisfied during reporting period 29 Closing balance, June 30, 2020 $ (143 ) The closing balance represents deferred revenue and was classified within current liabilities at June 30, 2020 . Pfizer Agreement In October 2014, the Company entered into a drug discovery collaboration and option agreement with Array BioPharma, Inc. ("Array," acquired by Pfizer Inc. during 2019) whereby Array provided services to facilitate the discovery, optimization and development of small molecule compounds that bind and specifically inhibit KRAS G12C. In June 2017, the two parties entered into a second, separate discovery collaboration and option agreement whereby Array provided services to facilitate the discovery, optimization and development of small molecule compounds that bind and specifically inhibit KRAS G12D. Both agreements established an option mechanism which enabled the Company to elect an exclusive worldwide license under the technology for the development and commercialization of certain products based on such compounds. Under the agreements, following the joint discovery periods which have concluded, the Company executed its options to retain exclusive worldwide licenses to develop, manufacture and commercialize inhibitors of KRAS G12C and KRAS G12D, including but not limited to, MRTX849 and MRTX1133. Under each agreement, Pfizer is entitled to potential development milestone payments of up to $9.3 million , and tiered sales milestone payments of up to $337.0 million based upon worldwide net sales, and tiered royalties in the high single digits to mid-teens on worldwide net sales of products arising from the collaborations. Under the agreements, the Company has incurred $4.3 million in development milestone payments from inception through June 30, 2020 . The royalty term for each agreement shall be payable on a country-by-country and product-by-product basis, and separately will terminate at the later of (i) the date of expiration of the last valid patent claim within the collaboration patent rights or the Pfizer background technology covering such product in the country in which such product is sold at the time of such sale, or (ii) 10 years after the first commercial sale of such product in such country. The Company may terminate each agreement at any time by providing 60 days prior written notice to Pfizer. Either party may terminate each agreement upon a material breach by the other party that remains uncured following 60 days after the date of written notice of such breach or upon certain bankruptcy events. No expense was incurred under these agreements for the three months ended June 30, 2020 . For the six months ended June 30, 2020 , the Company incurred expenses under these agreements with Pfizer of $4.5 million , consisting of a $3.0 million milestone payment for initiation of the first Phase 2 trial for MRTX849, and $1.5 million in research and development services. For the three months ended June 30, 2019 , the Company incurred expense of $1.5 million , consisting of research and development services. For the six months ended June 30, 2019 , the Company incurred expense of $4.0 million , consisting of a $1.0 million milestone payment for initiation of the first Phase 1 trial for MRTX849, and $3.0 million in research and development services. |
Warrants
Warrants | 6 Months Ended |
Jun. 30, 2020 | |
Equity [Abstract] | |
Warrants | Warrants As of June 30, 2020 , the following warrants for common stock were issued and outstanding: Issue date Expiration date Exercise price Number of warrants outstanding January 11, 2017 None $ 0.001 4,533,224 November 20, 2017 None $ 0.001 4,137,999 June 11, 2018 None $ 0.001 421,650 9,092,873 During the three and six months ended June 30, 2020 , 600,006 warrants for shares of the Company's common stock were exercised via cashless exercise, resulting in the issuance of 600,000 shares of common stock. No warrants were exercised during the three months ended June 30, 2019 . During the six months ended June 30, 2019 , 1,400,025 warrants for shares of the Company's common stock were exercised via cashless exercise, resulting in the issuance of 1,400,000 shares of common stock. Sale of Common Stock In January 2020, the Company sold 3,538,462 shares of its common stock at a public offering price of $97.50 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net proceeds from the transaction of $324.0 million . In June 2019, the Company sold 2,415,000 shares of its common stock at a public offering price at $97.00 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net proceeds from the transaction of $219.9 million . In January 2019, the Company sold 1,854,838 shares of its common stock at a public offering price of $62.00 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net cash proceeds from the transaction of $107.9 million . Share-based Compensation Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Research and development expense $ 11,457 $ 6,611 $ 23,305 $ 11,768 General and administrative expense 9,330 5,978 19,049 11,952 $ 20,787 $ 12,589 $ 42,354 $ 23,720 During the three and six months ended June 30, 2020 , 323,789 and 820,310 shares were issued under our equity incentive plans, generating net proceeds of $8.7 million and $23.9 million , respectively. During the three and six months ended June 30, 2019 , 97,489 and 332,887 shares were issued under our equity incentive plans, generating net proceeds of $1.6 million and $4.3 million , respectively. Disgorgement Proceeds In January 2019, the Company received a payment of $1.1 million |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2020 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | Commitments and Contingencies On June 24, 2014, the Company entered into a lease agreement for completed office and laboratory space located in San Diego, California. The office space under the lease is the Company's corporate headquarters. The lease commenced in two phases (in July 2014 and March 2015) at a combined total initial monthly rent of $24,100 per month. The leased property is subject to a 3% annual rent increase following availability. In addition to such base monthly rent, the Company is obligated to pay certain customary amounts for its share of operating expenses and facility amenities. The original lease provided for expiration on January 31, 2018. On March 23, 2017, the Company entered into a First Amendment to Lease Agreement to amend the original lease agreement and to extend the term of the original lease for one year through January 31, 2019. On April 5, 2018, the Company entered into a Second Amendment to Lease Agreement to extend the lease term through January 31, 2020. On August 2, 2018, the Company entered into a Third Amendment to Lease Agreement to expand the size of the existing space for an additional base rent of $4,000 per month. On October 30, 2019, the Company entered into a Fourth Amendment to Lease Agreement to extend the lease term to approximately October 1, 2020, and to expand the size of the existing space for no additional base rent. On March 4, 2020, the Company entered into a Fifth Amendment to Lease Agreement to expand the size of the existing space for no additional base rent. All other terms and covenants from the original lease agreement remain unchanged. The Company's building lease is considered to be an operating lease. The lease agreement indicates the interest rate applicable to the lease is 12% , therefore the Company used a discount rate of 12% to calculate the value of its lease obligations. The Company recorded less than $0.1 million and $0.1 million in operating lease cost for the three months ended June 30, 2020 and 2019 , respectively. The Company recorded $0.1 million and $0.2 million in operating lease cost for the six months ended June 30, 2020 and 2019 , respectively. The building lease has a remaining lease term of under one year from June 30, 2020 . As of June 30, 2020 , the condensed consolidated balance sheet includes a $0.7 million operating right-of-use asset within other long-term assets, and a $0.7 million operating lease liability in deferred revenue and other current liabilities, and remaining lease payments on an undiscounted basis are $0.2 million for 2020 and $0.1 million for 2021. On June 30, 2020, the Company entered into an amended and restated lease agreement (the "Amended and Restated Lease") for office and laboratory space located in San Diego, California, for the Company's future corporate headquarters. The Amended and Restated Lease supersedes in its entirety the original lease agreement for the Company's future corporate headquarters dated as of August 22, 2019. The commencement date of the Amended and Restated Lease is expected to be March 22, 2021, and the Amended and Restated Lease will have a lease term of 12 years ("Lease Term"), unless terminated earlier. The Lease Term has an initial abatement period, and the initial base rent payable will be approximately $0.6 million per month following the abatement period, which amount will increase by 3% per year over the Lease Term. The Company has also received customary incentives from the landlord for tenant improvements, which effectively reduce the total lease payments owed for the lease. As of June 30, 2020 , the Company had not taken control of the space and the Lease Term had not commenced. Accordingly, no |
Shareholders' Equity
Shareholders' Equity | 6 Months Ended |
Jun. 30, 2020 | |
Share-based Payment Arrangement [Abstract] | |
Shareholders' Equity | Warrants As of June 30, 2020 , the following warrants for common stock were issued and outstanding: Issue date Expiration date Exercise price Number of warrants outstanding January 11, 2017 None $ 0.001 4,533,224 November 20, 2017 None $ 0.001 4,137,999 June 11, 2018 None $ 0.001 421,650 9,092,873 During the three and six months ended June 30, 2020 , 600,006 warrants for shares of the Company's common stock were exercised via cashless exercise, resulting in the issuance of 600,000 shares of common stock. No warrants were exercised during the three months ended June 30, 2019 . During the six months ended June 30, 2019 , 1,400,025 warrants for shares of the Company's common stock were exercised via cashless exercise, resulting in the issuance of 1,400,000 shares of common stock. Sale of Common Stock In January 2020, the Company sold 3,538,462 shares of its common stock at a public offering price of $97.50 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net proceeds from the transaction of $324.0 million . In June 2019, the Company sold 2,415,000 shares of its common stock at a public offering price at $97.00 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net proceeds from the transaction of $219.9 million . In January 2019, the Company sold 1,854,838 shares of its common stock at a public offering price of $62.00 per share. After deducting underwriter discounts, commissions and offering expenses, the Company received net cash proceeds from the transaction of $107.9 million . Share-based Compensation Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Research and development expense $ 11,457 $ 6,611 $ 23,305 $ 11,768 General and administrative expense 9,330 5,978 19,049 11,952 $ 20,787 $ 12,589 $ 42,354 $ 23,720 During the three and six months ended June 30, 2020 , 323,789 and 820,310 shares were issued under our equity incentive plans, generating net proceeds of $8.7 million and $23.9 million , respectively. During the three and six months ended June 30, 2019 , 97,489 and 332,887 shares were issued under our equity incentive plans, generating net proceeds of $1.6 million and $4.3 million , respectively. Disgorgement Proceeds In January 2019, the Company received a payment of $1.1 million |
Subsequent Event
Subsequent Event | 6 Months Ended |
Jun. 30, 2020 | |
Subsequent Events [Abstract] | |
Subsequent Event | Subsequent Event At the Market Facility On July 2, 2020, the Company entered into a sales agreement pursuant to which the Company may, from time to time, sell shares of the Company's common stock, par value $0.001 per share, having an aggregate offering price of up to $200.0 million . ORIC Pharmaceuticals Agreement On August 3, 2020, the Company entered into a license agreement with ORIC Pharmaceuticals, Inc. ("ORIC") under which it granted an exclusive worldwide license to develop and commercialize small molecule inhibitors of the polycomb repressive complex 2, or PRC2 (the "ORIC Agreement"). Under the terms of the ORIC Agreement, Mirati received a one-time non-cash payment of $20.0 million in shares of ORIC common stock. The number of shares issued to the Company were based on a price of $34.00 per share, representing a premium of 10% to the 60-day volume weighted average trading price of ORIC shares. Mirati’s obligation under the ORIC Agreement is to transfer the licensed technology to ORIC. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Basis of Presentation | Basis of Presentation The unaudited condensed consolidated financial statements contained in this Quarterly Report on Form 10-Q have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission ("SEC") and, therefore, certain information and disclosures normally included in annual financial statements prepared in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP") have been omitted. In the opinion of management, the information reflects all adjustments necessary to make the results of operations for the interim periods a fair statement of such operations. All such adjustments are of a normal recurring nature. Interim results are not necessarily indicative of results for the full year. The condensed consolidated balance sheet at December 31, 2019 has been derived from the audited consolidated financial statements at that date, but does not include all information and footnotes required by U.S. GAAP for complete financial statements. These unaudited condensed consolidated financial statements should be read in conjunction with the audited financial statements included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31, 2019 . |
Use of Estimates | Use of Estimates The preparation of the Company's unaudited condensed consolidated financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenue and expenses during the reporting period. Reported amounts and note disclosures reflect the overall economic conditions that are most likely to occur and anticipated measures management intends to take. Actual results could differ materially from those estimates. Estimates and assumptions are reviewed quarterly. Any revisions to accounting estimates are recognized in the period in which the estimates are revised and in any future periods affected. |
Cash and Cash Equivalents | Cash and cash equivalents consist of cash and highly liquid securities with original maturities at the date of acquisition of ninety days or less. |
Short-term Investments | Investments with an original maturity of more than ninety days |
Concentration of Credit Risk | Concentration of Credit Risk The Company invests its excess cash in accordance with its investment policy. The Company's investments are comprised primarily of commercial paper and debt instruments of financial institutions, corporations, U.S. government-sponsored agencies and the U.S. Treasury. The Company mitigates credit risk by maintaining a diversified portfolio and limiting the amount of investment exposure as to institution, maturity and investment type. Financial instruments that potentially subject the Company to significant credit risk consist principally of cash equivalents and short-term investments. |
Revenue Recognition | Revenue Recognition The Company recognizes revenue in connection with a collaboration and license agreement in accordance with the guidance of Revenue From Contracts With Customers, Accounting Standards Codification ("ASC") Topic 606 ("Topic 606"). Under Topic 606, the Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration that the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements the Company determines are within the scope of Topic 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that the Company will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations, and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. |
Net Loss per Share | Net Loss per Share |
Recently Adopted Accounting Pronouncements | Recently Adopted Accounting Pronouncements In June 2016, the FASB issued Accounting Standards Update ("ASU") 2016-13, Financial Instruments-Credit Losses: Measurement of Credit Losses on Financial Instruments , which changes the impairment model for most financial assets and certain other instruments. For trade receivables and other instruments, entities are required to use a new forward-looking expected loss model that generally results in the earlier recognition of allowances for losses. For available-for-sale debt securities with unrealized losses, the losses are recognized as allowances rather than as reductions in the amortized cost of the securities. This guidance is effective for annual reporting periods beginning after December 15, 2019, including interim periods within those years. Effective January 1, 2020, the Company adopted the provisions of ASU 2016-13. The adoption did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. In August 2018, the FASB issued ASU 2018-13, Fair Value Measurement (Topic 820): Disclosure Framework - Changes to the Disclosure Requirements for Fair Value Measurement . The new guidance modifies the disclosure requirements on fair value measurements in Topic 820. The amendments in ASU 2018-13 are effective for all entities for fiscal years, and interim periods within those fiscal years, beginning after December 15, 2019. Effective January 1, 2020, the Company adopted the provisions of ASU 2018-13. The adoption did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. In December 2019, the FASB issued ASU 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes . The update includes removing several exceptions under the existing guidance and includes several simplification updates, none of which apply to the Company's current accounting for income taxes. The guidance is effective for fiscal years beginning after December 15, 2020 and early adoption is permitted. Effective January 1, 2020, the Company early adopted this updated guidance and it did not have a material impact on the Company's consolidated financial statements or related financial statement disclosures. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Accounting Policies [Abstract] | |
Schedule of Potentially Dilutive Securities not included in the Calculation of Diluted Net Loss per Share | The following table presents the weighted-average number of common share equivalents, calculated using the treasury stock method, not included in the calculation of diluted net loss per share due to the anti-dilutive effect of the securities: Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Common stock options 2,112,690 2,371,908 2,145,789 2,347,335 Common stock warrants 9,623,913 10,417,753 9,658,342 10,710,055 Total 11,736,603 12,789,661 11,804,131 13,057,390 |
Short-Term Investments (Tables)
Short-Term Investments (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Investments, Debt and Equity Securities [Abstract] | |
Schedule of Short-Term Investments | The following tables summarize the Company's short-term investments (dollars in thousands): As of June 30, 2020 Maturity Amortized cost Gross unrealized gains Gross unrealized losses Estimated fair value Corporate debt securities 2 years or less $ 177,244 $ 1,044 $ — $ 178,288 Commercial paper 1 year or less 233,296 594 (1 ) 233,889 U.S. Agency bonds 2 years or less 38,308 75 (1 ) 38,382 U.S. Treasury bills 1 year or less 63,411 52 (1 ) 63,462 $ 512,259 $ 1,765 $ (3 ) $ 514,021 As of December 31, 2019 Maturity Amortized cost Gross unrealized gains Gross unrealized losses Estimated fair value Corporate debt securities 2 years or less $ 160,065 $ 233 $ (1 ) $ 160,297 Commercial paper 1 year or less 120,862 74 — 120,936 U.S. Agency bonds 2 years or less 50,745 41 (4 ) 50,782 U.S. Treasury bills 2 years or less 36,474 27 (1 ) 36,500 $ 368,146 $ 375 $ (6 ) $ 368,515 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Fair Value Disclosures [Abstract] | |
Schedule of Assets and Liabilities Measured at Fair Value on a Recurring Basis | The following tables summarize the assets measured at fair value on a recurring basis (in thousands): June 30, 2020 Total Level 1 Level 2 Assets Cash and cash equivalents: Cash $ 12,198 $ 12,198 $ — Money market funds 119,491 119,491 — Total cash and cash equivalents 131,689 131,689 — Short-term investments: U.S. Treasury bills 63,462 63,462 — Corporate debt securities 178,288 — 178,288 Commercial paper 233,889 — 233,889 U.S. Agency bonds 38,382 — 38,382 Total short-term investments 514,021 63,462 450,559 Total $ 645,710 $ 195,151 $ 450,559 December 31, 2019 Total Level 1 Level 2 Assets Cash and cash equivalents: Cash $ 662 $ 662 $ — Money market funds 45,873 45,873 — Total cash and cash equivalents 46,535 46,535 — Short-term investments: U.S. Treasury bills 36,500 36,500 — Corporate debt securities 160,297 — 160,297 Commercial paper 120,936 — 120,936 U.S. Agency bonds 50,782 — 50,782 Total short-term investments 368,515 36,500 332,015 Total $ 415,050 $ 83,035 $ 332,015 |
Other Current Assets and Othe_2
Other Current Assets and Other Long-Term Assets (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | |
Schedule of Other Current Assets | Other current assets consisted of the following (in thousands): June 30, December 31, 2020 2019 Prepaid expenses $ 5,043 $ 5,672 Deposits and other receivables 1,471 2,119 Interest receivable 1,813 1,566 $ 8,327 $ 9,357 |
Property and Equipment, Net (Ta
Property and Equipment, Net (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Property, Plant and Equipment [Abstract] | |
Schedule of Property and Equipment | Property and equipment consisted of the following (in thousands): June 30, December 31, 2020 2019 Computer equipment $ 201 $ 201 Office and other equipment 329 329 Laboratory equipment 2,791 2,212 Leasehold improvements 63 63 Assets not placed in service 1,085 — Gross property and equipment 4,469 2,805 Less: Accumulated depreciation (1,282 ) (1,029 ) Property and equipment, net $ 3,187 $ 1,776 |
Accounts Payable, Accrued Lia_2
Accounts Payable, Accrued Liabilities and Long-Term Liabilities (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Payables and Accruals [Abstract] | |
Schedule of Accounts Payable and Accrued Liabilities | Accounts payable and accrued liabilities consisted of the following (in thousands): June 30, December 31, 2020 2019 Accounts payable $ 24,099 $ 16,367 Accrued clinical expense 22,920 21,290 Accrued development and other expense 4,743 2,510 Accrued compensation and benefits 5,081 7,915 $ 56,843 $ 48,082 |
Collaboration Agreements (Table
Collaboration Agreements (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Research and Development [Abstract] | |
Schedule of Activity in Contract Liabilities | The following table presents a summary of the activity in the Company's contract liabilities during the six months ended June 30, 2020 (in thousands): Opening balance, January 1, 2020 $ (172 ) Revenue from performance obligations satisfied during reporting period 29 Closing balance, June 30, 2020 $ (143 ) |
Warrants (Tables)
Warrants (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Equity [Abstract] | |
Schedule of Warrants Issued and Outstanding | As of June 30, 2020 , the following warrants for common stock were issued and outstanding: Issue date Expiration date Exercise price Number of warrants outstanding January 11, 2017 None $ 0.001 4,533,224 November 20, 2017 None $ 0.001 4,137,999 June 11, 2018 None $ 0.001 421,650 9,092,873 |
Shareholders' Equity (Tables)
Shareholders' Equity (Tables) | 6 Months Ended |
Jun. 30, 2020 | |
Share-based Payment Arrangement [Abstract] | |
Schedule of Employee Service Share-based Compensation Allocation | Total share-based compensation expense by statement of operations and comprehensive loss classification is presented below (in thousands): Three Months Ended June 30, Six Months Ended June 30, 2020 2019 2020 2019 Research and development expense $ 11,457 $ 6,611 $ 23,305 $ 11,768 General and administrative expense 9,330 5,978 19,049 11,952 $ 20,787 $ 12,589 $ 42,354 $ 23,720 |
Description of Business - Narra
Description of Business - Narrative (Details) | 6 Months Ended |
Jun. 30, 2020segment | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Number of operating segments | 1 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Narrative (Details) | 6 Months Ended |
Jun. 30, 2020 | |
Marketable Securities | |
Minimum original maturity period of marketable securities | 90 days |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Antidilutive Securities (Details) - shares | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||||
Antidilutive securities | 11,736,603 | 12,789,661 | 11,804,131 | 13,057,390 |
Common stock options | ||||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||||
Antidilutive securities | 2,112,690 | 2,371,908 | 2,145,789 | 2,347,335 |
Common stock warrants | ||||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||||
Antidilutive securities | 9,623,913 | 10,417,753 | 9,658,342 | 10,710,055 |
Short-Term Investments - Summar
Short-Term Investments - Summary (Details) - USD ($) $ in Thousands | 6 Months Ended | 12 Months Ended |
Jun. 30, 2020 | Dec. 31, 2019 | |
Debt Securities, Available-for-sale [Line Items] | ||
Amortized cost | $ 512,259 | $ 368,146 |
Gross unrealized gains | 1,765 | 375 |
Gross unrealized losses | (3) | (6) |
Estimated fair value | $ 514,021 | $ 368,515 |
Corporate debt securities | ||
Debt Securities, Available-for-sale [Line Items] | ||
Maturity | 2 years | 2 years |
Amortized cost | $ 177,244 | $ 160,065 |
Gross unrealized gains | 1,044 | 233 |
Gross unrealized losses | 0 | (1) |
Estimated fair value | $ 178,288 | $ 160,297 |
Commercial paper | ||
Debt Securities, Available-for-sale [Line Items] | ||
Maturity | 1 year | 1 year |
Amortized cost | $ 233,296 | $ 120,862 |
Gross unrealized gains | 594 | 74 |
Gross unrealized losses | (1) | 0 |
Estimated fair value | $ 233,889 | $ 120,936 |
U.S. Agency bonds | ||
Debt Securities, Available-for-sale [Line Items] | ||
Maturity | 2 years | 2 years |
Amortized cost | $ 38,308 | $ 50,745 |
Gross unrealized gains | 75 | 41 |
Gross unrealized losses | (1) | (4) |
Estimated fair value | $ 38,382 | $ 50,782 |
U.S. Treasury bills | ||
Debt Securities, Available-for-sale [Line Items] | ||
Maturity | 1 year | 2 years |
Amortized cost | $ 63,411 | $ 36,474 |
Gross unrealized gains | 52 | 27 |
Gross unrealized losses | (1) | (1) |
Estimated fair value | $ 63,462 | $ 36,500 |
Fair Value Measurements - Summa
Fair Value Measurements - Summary (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | $ 131,689 | $ 46,535 |
Total short-term investments | 514,021 | 368,515 |
Total | 645,710 | 415,050 |
U.S. Treasury bills | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 63,462 | 36,500 |
Corporate debt securities | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 178,288 | 160,297 |
Commercial paper | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 233,889 | 120,936 |
U.S. Agency bonds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 38,382 | 50,782 |
Cash | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 12,198 | 662 |
Money market funds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 119,491 | 45,873 |
Level 1 | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 131,689 | 46,535 |
Total short-term investments | 63,462 | 36,500 |
Total | 195,151 | 83,035 |
Level 1 | U.S. Treasury bills | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 63,462 | 36,500 |
Level 1 | Corporate debt securities | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 0 | 0 |
Level 1 | Commercial paper | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 0 | 0 |
Level 1 | U.S. Agency bonds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 0 | 0 |
Level 1 | Cash | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 12,198 | 662 |
Level 1 | Money market funds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 119,491 | 45,873 |
Level 2 | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 0 | 0 |
Total short-term investments | 450,559 | 332,015 |
Total | 450,559 | 332,015 |
Level 2 | U.S. Treasury bills | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 0 | 0 |
Level 2 | Corporate debt securities | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 178,288 | 160,297 |
Level 2 | Commercial paper | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 233,889 | 120,936 |
Level 2 | U.S. Agency bonds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total short-term investments | 38,382 | 50,782 |
Level 2 | Cash | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | 0 | 0 |
Level 2 | Money market funds | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Total cash and cash equivalents | $ 0 | $ 0 |
Other Current Assets and Othe_3
Other Current Assets and Other Long-Term Assets - Summary (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract] | ||
Prepaid expenses | $ 5,043 | $ 5,672 |
Deposits and other receivables | 1,471 | 2,119 |
Interest receivable | 1,813 | 1,566 |
Other current assets | 8,327 | 9,357 |
Deposits paid for research and development | 5,400 | 5,100 |
Long-term operating right-of-use asset | 700 | 600 |
Security deposit for lease | $ 600 | $ 300 |
Property and Equipment, Net - S
Property and Equipment, Net - Summary (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2019 | |
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | $ 4,469 | $ 4,469 | $ 2,805 | |
Less: Accumulated depreciation | (1,282) | (1,282) | (1,029) | |
Property and equipment, net | 3,187 | 3,187 | 1,776 | |
Depreciation | 100 | 253 | $ 99 | |
Computer equipment | ||||
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | 201 | 201 | 201 | |
Office and other equipment | ||||
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | 329 | 329 | 329 | |
Laboratory equipment | ||||
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | 2,791 | 2,791 | 2,212 | |
Leasehold improvements | ||||
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | 63 | 63 | 63 | |
Assets not placed in service | ||||
Property, Plant and Equipment [Line Items] | ||||
Gross property and equipment | $ 1,085 | $ 1,085 | $ 0 |
Accounts Payable, Accrued Lia_3
Accounts Payable, Accrued Liabilities and Long-Term Liabilities - Summary (Details) - USD ($) $ in Thousands | Jun. 30, 2020 | Dec. 31, 2019 |
Payables and Accruals [Abstract] | ||
Accounts payable | $ 24,099 | $ 16,367 |
Accrued clinical expense | 22,920 | 21,290 |
Accrued development and other expense | 4,743 | 2,510 |
Accrued compensation and benefits | 5,081 | 7,915 |
Total accounts payable and accrued liabilities | 56,843 | 48,082 |
Long-term liabilities | $ 1,251 | $ 999 |
Collaboration Agreements - Narr
Collaboration Agreements - Narrative (Details) - USD ($) | Jan. 07, 2018 | Oct. 31, 2014 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2018 |
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Expenses related to collaboration agreement | $ 65,083,000 | $ 38,324,000 | $ 136,791,000 | $ 72,564,000 | |||
BeiGene Agreement | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Up-front fee received | $ 10,000,000 | ||||||
Revenue from performance obligation expected to be earned | $ 123,000,000 | ||||||
Termination of contract, period after first commercial sale of product | 10 years | ||||||
Period required for notice of termination of contract | 60 days | ||||||
Revenue from performance obligations satisfied during reporting period | 29,000 | ||||||
BeiGene Agreement | Licenses of Intellectual Property | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Revenue from performance obligation earned | 0 | 0 | 0 | 0 | $ 9,500,000 | ||
BeiGene Agreement | Manufacturing Supply Services | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Revenue from performance obligation earned | 1,600,000 | $ 500,000 | |||||
Payments received in advance | 0 | (600,000) | (300,000) | (1,800,000) | |||
Revenue from performance obligations satisfied during reporting period | 200,000 | ||||||
BeiGene Agreement | Milestone Payments | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Revenue from performance obligation expected to be earned | 5,000,000 | 5,000,000 | |||||
Milestone payments earned | 0 | 0 | 0 | 0 | |||
BeiGene Agreement | Royalties | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Revenue | 0 | 0 | 0 | 0 | |||
Pfizer Agreement | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Termination of contract, period after first commercial sale of product | 10 years | ||||||
Period required for notice of termination of contract | 60 days | ||||||
Expenses related to collaboration agreement | $ 0 | $ 1,500,000 | 4,500,000 | 4,000,000 | |||
Pfizer Agreement | Milestone Payments | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Expenses related to collaboration agreement | 3,000,000 | 1,000,000 | |||||
Pfizer Agreement | Research and Development Services | |||||||
Research and Development Arrangement, Contract to Perform for Others [Line Items] | |||||||
Expenses related to collaboration agreement | $ 1,500,000 | $ 3,000,000 |
Collaboration Agreements - Acti
Collaboration Agreements - Activity in Contract Liabilities (Details) - BeiGene Agreement $ in Thousands | 6 Months Ended |
Jun. 30, 2020USD ($) | |
Movement in Deferred Revenue [Roll Forward] | |
Opening balance at beginning of period | $ (172) |
Revenue from performance obligations satisfied during reporting period | 29 |
Closing balance at end of period | $ (143) |
Warrants - Summary (Details)
Warrants - Summary (Details) - $ / shares | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Class of Warrant or Right [Line Items] | ||||
Number of warrants outstanding (shares) | 9,092,873 | 9,092,873 | ||
Warrants exercised via cashless exercises (shares) | 600,006 | 0 | 600,006 | 1,400,025 |
Common stock issued from exercise of warrants (shares) | 600,000 | 600,000 | 1,400,000 | |
January 11, 2017 Warrants | ||||
Class of Warrant or Right [Line Items] | ||||
Exercise price of warrants (USD per share) | $ 0.001 | $ 0.001 | ||
Number of warrants outstanding (shares) | 4,533,224 | 4,533,224 | ||
November 20, 2017 Warrants | ||||
Class of Warrant or Right [Line Items] | ||||
Exercise price of warrants (USD per share) | $ 0.001 | $ 0.001 | ||
Number of warrants outstanding (shares) | 4,137,999 | 4,137,999 | ||
June 11, 2018 Warrants | ||||
Class of Warrant or Right [Line Items] | ||||
Exercise price of warrants (USD per share) | $ 0.001 | $ 0.001 | ||
Number of warrants outstanding (shares) | 421,650 | 421,650 |
Commitments and Contingencies -
Commitments and Contingencies - Narrative (Details) - USD ($) | 3 Months Ended | 6 Months Ended | |||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Dec. 31, 2019 | |
Lessee, Lease, Description [Line Items] | |||||
Right-of-use asset | $ 700,000 | $ 700,000 | $ 600,000 | ||
Current Headquarters | |||||
Lessee, Lease, Description [Line Items] | |||||
Minimum monthly rental expense | $ 4,000 | ||||
Discount rate (as a percent) | 12.00% | 12.00% | |||
Operating lease cost | $ 100,000 | $ 100,000 | $ 100,000 | $ 200,000 | |
Remaining lease term | 1 year | 1 year | |||
Right-of-use asset | $ 700,000 | $ 700,000 | |||
Operating lease liability | 700,000 | 700,000 | |||
Remaining lease payments for remainder of fiscal year | 200,000 | 200,000 | |||
Remaining lease payments for next year | 100,000 | 100,000 | |||
Future Headquarters | |||||
Lessee, Lease, Description [Line Items] | |||||
Right-of-use asset | 0 | 0 | |||
Operating lease liability | $ 0 | 0 | |||
Building | Current Headquarters | |||||
Lessee, Lease, Description [Line Items] | |||||
Minimum monthly rental expense | $ 24,100 | ||||
Annual rent increase (as a percent) | 3.00% | 3.00% | |||
Building | Future Headquarters | |||||
Lessee, Lease, Description [Line Items] | |||||
Minimum monthly rental expense | $ 600,000 | ||||
Annual rent increase (as a percent) | 3.00% | 3.00% | |||
Lease term | 12 years | 12 years |
Shareholders' Equity - Narrativ
Shareholders' Equity - Narrative (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||||
Jan. 31, 2020 | Jun. 30, 2019 | Jan. 31, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Share-based Payment Arrangement [Abstract] | |||||||
Stock issued in transaction (shares) | 3,538,462 | 2,415,000 | 1,854,838 | ||||
Sale price of common stock (USD per share) | $ 97.50 | $ 97 | $ 62 | $ 97 | $ 97 | ||
Proceeds from sale of stock | $ 324,000 | $ 219,900 | $ 107,900 | ||||
Stock issued pursuant to stock option exercises (shares) | 323,789 | 97,489 | 820,310 | 332,887 | |||
Proceeds from stock options exercised | $ 8,700 | $ 1,600 | $ 23,900 | $ 4,300 | |||
Proceeds from disgorgement of shareholders' short-swing profits | $ 1,100 | $ 41 | $ 1,050 |
Shareholders' Equity - Summary
Shareholders' Equity - Summary (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2020 | Jun. 30, 2019 | Jun. 30, 2020 | Jun. 30, 2019 | |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||||
Allocated share-based compensation expense | $ 20,787 | $ 12,589 | $ 42,354 | $ 23,720 |
Research and development expense | ||||
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||||
Allocated share-based compensation expense | 11,457 | 6,611 | 23,305 | 11,768 |
General and administrative expense | ||||
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||||
Allocated share-based compensation expense | $ 9,330 | $ 5,978 | $ 19,049 | $ 11,952 |
Subsequent Event - Narrative (D
Subsequent Event - Narrative (Details) - USD ($) $ / shares in Units, $ in Millions | Aug. 03, 2020 | Jul. 02, 2020 | Jun. 30, 2020 | Jan. 31, 2020 | Dec. 31, 2019 | Jun. 30, 2019 | Jan. 31, 2019 |
Subsequent Event [Line Items] | |||||||
Common stock, par value (USD per share) | $ 0.001 | $ 0.001 | |||||
Sale price of common stock (USD per share) | $ 97.50 | $ 97 | $ 62 | ||||
Subsequent Event | Common Stock | |||||||
Subsequent Event [Line Items] | |||||||
Common stock, par value (USD per share) | $ 0.001 | ||||||
Aggregate offering price | $ 200 | ||||||
License Agreement with ORIC Pharmaceuticals, Inc. | Subsequent Event | |||||||
Subsequent Event [Line Items] | |||||||
One-time non-cash payment for license agreement | $ 20 | ||||||
Sale price of common stock (USD per share) | $ 34 | ||||||
Premium rate (as a percent) | 10.00% |
Uncategorized Items - mrtx-2020
Label | Element | Value |
Restricted Cash | us-gaap_RestrictedCash | $ 0 |
Restricted Cash | us-gaap_RestrictedCash | 620,000 |
Pfizer Discovery and Collaboration Agreement [Member] | Development Milestone Payments [Member] | ||
Research and Development Arrangement, Discovery and Collaboration Agreement, Compensation Expected to be Paid | mrtx_ResearchandDevelopmentArrangementDiscoveryandCollaborationAgreementCompensationExpectedtobePaid | 9,300,000 |
Research and Development Arrangement, Discovery and Collaboration Agreement, Milestone Payments Paid | mrtx_ResearchandDevelopmentArrangementDiscoveryandCollaborationAgreementMilestonePaymentsPaid | 4,300,000 |
Pfizer Discovery and Collaboration Agreement [Member] | Sales Milestone Payments [Member] | ||
Research and Development Arrangement, Discovery and Collaboration Agreement, Compensation Expected to be Paid | mrtx_ResearchandDevelopmentArrangementDiscoveryandCollaborationAgreementCompensationExpectedtobePaid | $ 337,000,000 |