RBC Capital Markets, LLC
200 Vesey Street, 8th Floor
New York, NY 10281
Stifel, Nicolaus & Company, Incorporated
237 Park Ave, 8th Floor
New York, NY 10017
June 8, 2015
VIA EDGAR
Securities and Exchange Commission
Division of Corporation Finance
100 F Street, N.E.
Washington, D.C. 20549
| Re: | Biotie Therapies Corp. | |
| Registration Statement on Form F-1 | ||
| File No. 333-204147 |
Ladies and Gentlemen:
Pursuant to Rule 461 promulgated under the Securities Act of 1933, as amended (the “Securities Act”), the undersigned, as representatives of the several underwriters (the “Underwriters”) in connection with the offering pursuant to the above-captioned Registration Statement, hereby join in the request of Biotie Therapies Corp. that the effective date of the above-captioned Registration Statement be accelerated to 2:00pm on June 10, 2015, or as soon thereafter as practicable.
In connection with this acceleration request and pursuant to Rule 460 under the Securities Act, please be advised that between June 4, 2015 and the date hereof, copies of the preliminary prospectus dated June 4, 2015 were distributed as follows:
| To Whom Distributed | Number of Copies |
| Prospective Underwriters | 0 |
| Prospective Dealers | 0 |
| Institutional Investors | 993 |
| Individual Investors | 2017 |
| Rating Agencies | 0 |
| Others | 0 |
The undersigned, as representatives of the several Underwriters, have and will, and each Underwriter and dealer has advised the undersigned that it has and will, comply with Rule 15c2-8 promulgated under the Securities Exchange Act of 1934, as amended.
| Very truly yours, | |||
| RBC Capital Markets, LLC | |||
| Stifel, Nicolaus & Company, Incorporated | |||
| As Representatives of the Several Underwriters | |||
| By: | RBC Capital Markets, LLC | ||
| By: | /s/ Jennifer Caruso | ||
| Name: Jennifer Caruso | |||
| Title: Managing Director | |||
| By: | Stifel, Nicolaus & Company, Incorporated | ||
| By: | /s/ Keith Lister | ||
| Name: Keith Lister | |||
| Title: Managing Director | |||
