| Cover | Dec. 06, 2021 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Dec. 6, 2021 |
| Entity File Number | 001-38022 |
| Entity Registrant Name | MATINAS BIOPHARMA HOLDINGS, INC. |
| Entity Central Index Key | 0001582554 |
| Entity Tax Identification Number | 46-3011414 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 1545 Route 206 South |
| Entity Address, Address Line Two | Suite 302 |
| Entity Address, City or Town | Bedminster |
| Entity Address, State or Province | NJ |
| Entity Address, Postal Zip Code | 07921 |
| City Area Code | (908) |
| Local Phone Number | 443-1860 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock |
| Trading Symbol | MTNB |
| Security Exchange Name | NYSEAMER |
| Entity Emerging Growth Company | false |
| Entity Information, Former Legal or Registered Name | Not Applicable |
