5AM Ventures IV SC 13G scPharmaceuticals Inc.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT TO RULES 13d-1 (b), (c) AND (d) AND AMENDMENTS THERETO FILED PURSUANT TO 13d-2 (b)

(Amendment No.     )*

scPharmaceuticals Inc.

(Name of Issuer)

Common Stock, par value $0.0001 per share

(Title of Class of Securities)

810648 105

(CUSIP Number)

November 21, 2017

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

o Rule 13d-1(b)

x Rule 13d-1(c)

o Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. 5AM Ventures IV, L.P.
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization Delaware, United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 3,123,303 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 3,123,303  shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,123,303 shares (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 17.7% (3)
	12	Type of Reporting Person* PN

(1)This Schedule 13G is filed by 5AM Ventures IV, L.P., a Delaware limited partnership (“Ventures IV”), 5AM Co-Investors IV, L.P., a Delaware limited partnership (“Co-Investors IV”), 5AM Partners IV, LLC, a Delaware limited liability company (“Partners IV”), Dr. John D. Diekman (“Diekman”), Andrew J. Schwab (“Schwab”), and Dr. Scott M. Rocklage (“Rocklage” and together with Ventures IV, Co-Investors IV, Partners IV, Diekman and Schwab, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Partners IV serves as the sole general partner of Ventures IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV; however, they disclaim beneficial ownership of the shares held by Ventures IV except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

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CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. 5AM Co-Investors IV, L.P.
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization Delaware, United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 130,137 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 130,137 shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 130,137 shares of Common Stock (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 0.7% (3)
	12	Type of Reporting Person* PN

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Partners IV serves as the sole general partner of Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Co-Investors IV; however, they disclaim beneficial ownership of the shares held by Co-Investors IV except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

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CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. 5AM Partners IV, LLC
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization Delaware, United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 3,253,440 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 3,253,440 shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,253,440 shares (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 18.5% (3)
	12	Type of Reporting Person* OO

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Includes 3,123,303 shares of Common Stock held by Ventures IV and 130,137 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

4

CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. Dr. John D. Diekman
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 3,253,440 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 3,253,440 shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,253,440 shares (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 18.5% (3)
	12	Type of Reporting Person* IN

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Includes 3,123,303 shares of Common Stock held by Ventures IV and 130,137 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

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CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. Andrew J. Schwab
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 3,253,440 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 3,253,440 shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,253,440 shares (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 18.5% (3)
	12	Type of Reporting Person* IN

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Includes 3,123,303 shares of Common Stock held by Ventures IV and 130,137 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

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CUSIP No. 810648 105						13 G
	1	Names of Reporting Persons. Dr. Scott M. Rocklage
	2	Check the Appropriate Box if a Member of a Group*
		(a)		o
		(b)		x(1)
	3	SEC Use Only
	4	Citizenship or Place of Organization United States of America
Number of Shares Beneficially Owned by Each Reporting Person With			5		Sole Voting Power 0 shares
			6		Shared Voting Power 3,253,440 shares (2)
			7		Sole Dispositive Power 0 shares
			8		Shared Dispositive Power 3,253,440 shares (2)
	9	Aggregate Amount Beneficially Owned by Each Reporting Person 3,253,440 shares (2)
	10	Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o
	11	Percent of Class Represented by Amount in Row 9 18.5% (3)
	12	Type of Reporting Person* IN

(1)This Schedule 13G is filed by the Reporting Persons. The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)Includes 3,123,303 shares of Common Stock held by Ventures IV and 130,137 shares of Common Stock held by Co-Investors IV.  Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein.  The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017.

(3)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

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Introductory Note: This Statement on Schedule 13G (this “Statement”) is filed on behalf of the Reporting Persons, in respect of shares of Common Stock, par value $0.0001 per share (“Common Stock”), of scPharmaceuticals Inc., a Delaware corporation (the “Issuer”).

Item 1
	(a)	Name of Issuer: scPharmaceuticals Inc.
		Address of Issuer’s Principal Executive Offices: 2400 District Avenue, Suite 310 Burlington, Massachusetts 01830
Item 2
	(a)	Name of Person(s) Filing: 5AM Ventures IV, L.P. (“Ventures IV”) 5AM Co-Investors IV, L.P. (“Co-Investors IV”) 5AM Partners IV, LLC (“Partners IV”) Dr. John D. Diekman (“Diekman”) Andrew J. Schwab (“Schwab”) Dr. Scott M. Rocklage (“Rocklage”)
	(b)	Address of Principal Business Office: c/o 5AM Ventures 501 Second Street, Suite 350 San Francisco, CA 94107
	(b)	Citizenship: Entities: Individuals:	5AM Ventures IV, L.P. 5AM Co-Investors IV, L.P. 5AM Partners IV, LLC Diekman Schwab Rocklage	-         Delaware -         Delaware -         Delaware -         United States of America -         United States of America -         United States of America
	(d)	Title of Class of Securities: Common Stock
	(e)	CUSIP Number: 810648 105
Item 3	Not applicable.

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Item 4	Ownership.
The following information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of December 1, 2017:

Reporting Persons	Shares Held Directly	Sole Voting Power	Shared Voting Power	Sole Dispositive Power	Shared Dispositive Power	Beneficial Ownership	Percentage of Class (4)
Ventures IV (1) (3)	3,123,303	—	3,123,303	—	3,123,303	3,123,303	17.7	%
Co-Investors IV (2) (3)	130,137	—	130,137	—	130,137	130,137	0.7	%
Partners IV (1) (2) (3)	—	—	3,253,440	—	3,253,440	3,253,440	18.5	%
Diekman (1) (2) (3)	—	—	3,253,440	—	3,253,440	3,253,440	18.5	%
Schwab (1) (2) (3)	—	—	3,253,440	—	3,253,440	3,253,440	18.5	%
Rocklage (1) (2) (3)	—	—	3,253,440	—	3,253,440	3,253,440	18.5	%

(1)Includes 3,123,303 shares of Common Stock held by Ventures IV.

(2)Includes 130,137 shares of Common Stock held by Co-Investors IV.

(3)Partners IV serves as the sole general partner of Ventures IV and Co-Investors IV.  Diekman, Schwab and Rocklage are managing members of Partners IV and share voting and dispositive power over the shares held by Ventures IV and Co-Investors IV; however, they disclaim beneficial ownership of the shares held by such entities except to the extent of their pecuniary interests therein.

(4)This percentage is calculated based on 17,610,151 shares of Common Stock outstanding as of November 21, 2017 upon the closing of the Issuer’s initial public offering, as reported in the Issuer’s prospectus (the “Prospectus”) filed with the Securities and Exchange Commission (the “SEC”) on November 21, 2017 pursuant to Rule 424(b)(4) of the Securities Act of 1933, as amended.  The number of shares of Common Stock outstanding does not give effect to the underwriters’ option to purchase up to an additional 960,000 shares of Common Stock within 30 days from the date of the Prospectus.

Item 5	Ownership of Five Percent or Less of a Class.
If this statement is being filed to report the fact that as of the date hereof, the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities, check the following:     o
Item 6	Ownership of More than Five Percent on Behalf of Another Person.
Not applicable.
Item 7	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company.
Not applicable.
Item 8	Identification and Classification of Members of the Group.
Not applicable.
Item 9	Notice of Dissolution of Group.
Not applicable.

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Item 10	Certification.
Not applicable.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Dated: December 1, 2017

5AM Ventures IV, L.P.		5AM Co-Investors IV, L.P.
By:	5AM Partners IV, LLC	By:	5AM Partners IV, LLC
	its General Partner		its General Partner
By:	/s/ Andrew J. Schwab	By:	/s/ Andrew J. Schwab
	Name: Andrew J. Schwab		Name: Andrew J. Schwab
	Title: Managing Member		Title: Managing Member
5AM Partners IV, LLC
By:	/s/ Andrew J. Schwab
	Name: Andrew J. Schwab
	Title: Managing Member
	/s/ Dr. John D. Diekman		/s/ Andrew J. Schwab
	Dr. John D. Diekman		Andrew J. Schwab
	/s/ Dr. Scott M. Rocklage
	Dr. Scott M. Rocklage

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Exhibit(s):

A - Joint Filing Statement

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EXHIBIT A

JOINT FILING STATEMENT

We, the undersigned, hereby express our agreement that the attached Schedule 13G (or any amendments thereto) relating to the Common Stock of scPharmaceuticals Inc. is filed on behalf of each of us.

Dated: December 1, 2017

5AM Ventures IV, L.P.		5AM Co-Investors IV, L.P.
By:	5AM Partners IV, LLC	By:	5AM Partners IV, LLC
	its General Partner		its General Partner
By:	/s/ Andrew J. Schwab	By:	/s/ Andrew J. Schwab
	Name: Andrew J. Schwab		Name: Andrew J. Schwab
	Title: Managing Member		Title: Managing Member
5AM Partners IV, LLC
By:	/s/ Andrew J. Schwab
	Name: /s/ Andrew J. Schwab
	Title: Managing Member
	/s/ Dr. John D. Diekman		/s/ Andrew J. Schwab
	Dr. John D. Diekman		Andrew J. Schwab
	/s/ Dr. Scott M. Rocklage
	/s/ Dr. Scott M. Rocklage

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