uniQure (QURE) SC 13G/A uniQure N.V.

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

SCHEDULE 13G

Under the Securities Exchange Act of 1934
(Amendment No. 2)*

uniQure N.V.

(Name of Issuer)

Ordinary Shares

(Title of Class of Securities)

N90064101

(CUSIP Number)

December 31, 2016

(Date of Event Which Requires Filing of this Statement)

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

o Rule 13d-1(b)

o Rule 13d-1(c)

x Rule 13d-1(d)

*The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Gilde Healthcare Holding BV
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) OO

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CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Coöperatieve Gilde Healthcare II U.A.
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) OO

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CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Gilde Healthcare II Management BV
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) OO

4

CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Marc Olivier Perret
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) IN

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CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Edwin de Graaf
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) IN

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CUSIP No. N90064101						Schedule 13G
	1.	Names of Reporting Persons Martemanshurk BV (100% owned by Pieter van der Meer)
	2.	Check the Appropriate Box if a Member of a Group (See Instructions)
		(a)		o
		(b)		o
	3.	SEC Use Only
	4.	Citizenship or Place of Organization The Netherlands
Number of Shares Beneficially Owned by Each Reporting Person With			5.		Sole Voting Power 0
			6.		Shared Voting Power 1,056,946
			7.		Sole Dispositive Power 0
			8.		Shared Dispositive Power 1,056,946
	9.	Aggregate Amount Beneficially Owned by Each Reporting Person 1,056,946
	10.	Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)  o
	11.	Percent of Class Represented by Amount in Row (9) 4.2%
	12.	Type of Reporting Person (See Instructions) OO

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CUSIP No. N90064101 Schedule 13G

Item 1.
	(a)		Name of Issuer: uniQure, N.V.
	(b)		Address of the Issuer’s Principal Executive Offices: Meibergdreef 61 1105 BA Amsterdam The Netherlands
Item 2.
	(a)		Name of Person Filing: Gilde Healthcare Holding BV Coöperatieve Gilde Healthcare II UA Gilde Healthcare II Management BV Marc Olivier Perret Edwin de Graaf Martemanshurk BV (100% owned by Pieter van der Meer)
	(b)		Address of Principal Business Office or if none, Residence: c/o Gilde Healthcare Partners BV Newtonlaan 91 3584 BP Utrecht The Netherlands
	(c)		Citizenship: Each of the reporting persons is organized and based in the Netherlands
	(d)		Title and Class of Securities: Ordinary Shares, nominal value EUR 0.05 per share
	(e)		CUSIP Number: N90064101
Item 3.
Not applicable.
Item 4.		Ownership:
Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item 1.
		(a)		Amount beneficially owned:
				Gilde Healthcare Holding BV	1,056,946 shares
				Coöperatieve Gilde Healthcare II UA	1,056,946 shares
				Gilde Healthcare II Management BV	1,056,946 shares
				Marc Olivier Perret	1,056,946 shares
				Edwin de Graaf	1,056,946 shares
				Martemanshurk BV (100% owned by Pieter van der Meer)	1,056,946 shares
				Coöperatieve Gilde Healthcare II UA directly owns 1,047,046 ordinary shares of the Issuer and a warrant to purchase 9,900 ordinary shares of the Issuer (the “Shares). The manager of Coöperatieve Gilde Healthcare II UA is Gilde Healthcare II Management BV which is owned by Gilde Healthcare Holding BV. The three managing partners of Gilde Healthcare Holding BV are Edwin de Graaf, Marc Olivier Perret and Martemanshurk BV (of which Pieter van der Meer is the owner and manager).

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CUSIP No. N90064101 Schedule 13G

	Each of Messrs. Perret, De Graaf, van der Meer and Martemanshurk BV disclaim beneficial ownership of the Shares except to the extent of his or its pecuniary interest therein.
(b)	Percent of class:
	Gilde Healthcare Holding BV			4.2%
	Coöperatieve Gilde Healthcare II UA			4.2%
	Gilde Healthcare II Management BV			4.2%
	Marc Olivier Perret			4.2%
	Edwin de Graaf			4.2%
	Martemanshurk BV (100% owned by Pieter van der Meer)			4.2%
(c)	Number of shares as to which the person has:
	(i)	Sole power to vote or to direct the vote:
		Gilde Healthcare Holding BV		0 shares
		Coöperatieve Gilde Healthcare II UA		0 shares
		Gilde Healthcare II Management BV		0 shares
		Marc Olivier Perret		0 shares
		Edwin de Graaf		0 shares
		Martemanshurk BV (100% owned by Pieter van der Meer)		0 shares
	(ii)	Shared power to vote or to direct the vote:
		Gilde Healthcare Holding BV		1,056,946 shares
		Coöperatieve Gilde Healthcare II UA		1,056,946 shares
		Gilde Healthcare II Management BV		1,056,946 shares
		Marc Olivier Perret		1,056,946 shares
		Edwin de Graaf		1,056,946 shares
		Martemanshurk BV (100% owned by Pieter van der Meer)		1,056,946 shares
		Includes a warrant to purchase 9,900 ordinary shares of the Issuer.
	(iii)	Sole power to dispose or to direct the disposition of:
		Gilde Healthcare Holding BV	0 shares
		Coöperatieve Gilde Healthcare II UA	0 shares
		Gilde Healthcare II Management BV	0 shares
		Marc Olivier Perret	0 shares
		Edwin de Graaf	0 shares
		Martemanshurk BV (100% owned by Pieter van der Meer)	0 shares
	(iv)	Shared power to dispose or to direct the disposition of:
		Gilde Healthcare Holding BV	1,056,946 shares
		Coöperatieve Gilde Healthcare II UA	1,056,946 shares
		Gilde Healthcare II Management BV	1,056,946 shares
		Marc Olivier Perret	1,056,946 shares
		Edwin de Graaf	1,056,946 shares
		Martemanshurk BV (100% owned by Pieter van der Meer)	1,056,946 shares
		Includes a warrant to purchase 9,900 ordinary shares of the Issuer.

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CUSIP No. N90064101 Schedule 13G

Item 5.	Ownership of Five Percent or Less of a Class:
If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than 5 percent of the class of securities, check the following   x.
Item 6.	Ownership of More than Five Percent on Behalf of Another Person:
Not Applicable
Item 7.	Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person:
Not Applicable
Item 8.	Identification and Classification of Members of the Group:
Item 9.	Notice of Dissolution of Group:
Not Applicable

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CUSIP No. N90064101 Schedule 13G

Item 10.	Certifications:
Not Applicable

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

Gilde Healthcare Holding BV
By:	/s/ / Marc Olivier Perret	By:	/s/ Edwin de Graaf	By:	/s/ Pieter van der Meer
Name:	Marc Olivier Perret	Name:	Edwin de Graaf	Name:	Martemanshurk BV
Title:	Managing Partner	Title:	Managing Partner		By:	Pieter van der Meer
					Title:	Managing Partner
*****
Coöperatieve Gilde Healthcare II U.A.
By:	/s/ / Marc Olivier Perret	By:	/s/ Edwin de Graaf	By:	/s/ Pieter van der Meer
Name:	Marc Olivier Perret	Name:	Edwin de Graaf	Name:	Martemanshurk BV
Title:	Managing Partner	Title:	Managing Partner		By:	Pieter van der Meer
					Title:	Managing Partner
*****
Gilde Healthcare II Management BV
By:	/s/ Marc Olivier Perret	By:	/s/ Edwin de Graaf	By:	/s/ Pieter van der Meer
Name:	Marc Olivier Perret	Name:	Edwin de Graaf	Name:	Martemanshurk BV
Title:	Managing Partner	Title:	Managing Partner		By:	Pieter van der Meer
					Title:	Managing Partner
*****
By:	/s/ / Marc Olivier Perret	By:	/s/ Edwin de Graaf	By:	/s/ Pieter van der Meer
Name:	Marc Olivier Perret	Name:	Edwin de Graaf	Name:	Martemanshurk BV
					By:	Pieter van der Meer
					Title:	Managing Partner

February 3, 2017

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CUSIP No. N90064101 Schedule 13G

EXHIBIT INDEX

Exhibit 1Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended.

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