Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
10X GENOMICS INC	CL A COM	88025U109	10,762	76,000	SH		SOLE		76,000	0	0
ABCAM PLC	ADS	000380204	19,934	925,000	SH		SOLE		925,000	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	35,182	700,000	SH		SOLE		700,000	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	86,204	1,612,500	SH		SOLE		1,612,500	0	0
ACCOLADE INC	COM	00437E102	21,750	500,000	SH		SOLE		500,000	0	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	4,690	3,782,457	SH		SOLE		3,782,457	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	17,314	2,676,100	SH		SOLE		2,676,100	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	8,328	1,545,000	SH		SOLE		1,545,000	0	0
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	37,548	635,000	SH		SOLE		635,000	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	12,435	1,580,000	SH		SOLE		1,580,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	109,344	2,523,521	SH		SOLE		2,523,521	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	13,297	515,371	SH		SOLE		515,371	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	47,927	306,750	SH		SOLE		306,750	0	0
ALIGN TECHNOLOGY INC	COM	016255101	87,371	163,500	SH		SOLE		163,500	0	0
ALLAKOS INC	COM	01671P100	47,810	341,500	SH		SOLE		341,500	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	43,540	335,000	SH		SOLE		335,000	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	20,514	4,195,000	SH		SOLE		4,195,000	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	23,760	1,029,000	SH		SOLE		1,029,000	0	0
ANAPTYSBIO INC	COM	032724106	6,652	309,413	SH		SOLE		309,413	0	0
ANNEXON INC	COM	03589W102	1,137	45,413	SH		SOLE		45,413	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	13,995	635,837	SH		SOLE		635,837	0	0
ARDELYX INC	COM	039697107	33,308	5,148,112	SH		SOLE		5,148,112	0	0
ARGENX SE	SPONSORED ADR	04016X101	84,551	287,500	SH		SOLE		287,500	0	0
ARVINAS INC	COM	04335A105	63,358	746,000	SH		SOLE		746,000	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	38,943	233,500	SH		SOLE		233,500	0	0
ATEA PHARMACEUTICALS INC	COM	04683R106	70,917	1,697,403	SH		SOLE		1,697,403	0	0
ATHIRA PHARMA INC	COM	04746L104	29,486	860,902	SH		SOLE		860,902	0	0
ATRECA INC	CL A COM	04965G109	7,287	451,230	SH		SOLE		451,230	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	10,700	773,669	SH		SOLE		773,669	0	0
BAXTER INTL INC	COM	071813109	24,152	301,000	SH		SOLE		301,000	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	3,442	309,000	SH		SOLE		309,000	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	58,138	225,000	SH		SOLE		225,000	0	0
BIOGEN INC	COM	09062X103	24,486	100,000	SH		SOLE		100,000	0	0
BIOGEN INC	COM	09062X103	31,832	130,000	SH	Call	SOLE		130,000	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	22,229	253,500	SH		SOLE		253,500	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	94,430	842,000	SH		SOLE		842,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	28,760	800,000	SH		SOLE		800,000	0	0
BRIGHT HORIZONS FAM SOL IN D	COM	109194100	28,630	165,500	SH		SOLE		165,500	0	0
CENTENE CORP DEL	COM	15135B101	43,822	730,000	SH		SOLE		730,000	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	16,563	999,000	SH		SOLE		999,000	0	0
CERTARA INC	COM	15687V109	5,058	150,000	SH		SOLE		150,000	0	0
CHIASMA INC	COM	16706W102	9,294	2,136,514	SH		SOLE		2,136,514	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	10,608	668,849	SH		SOLE		668,849	0	0
COHERUS BIOSCIENCES INC	COM	19249H103	20,204	1,162,500	SH		SOLE		1,162,500	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	22,033	1,100,000	SH		SOLE		1,100,000	0	0
COMPUGEN LTD	ORD	M25722105	13,728	1,133,600	SH		SOLE		1,133,600	0	0
CONMED CORP	COM	207410101	8,736	78,000	SH		SOLE		78,000	0	0
CONSTELLATION PHARMCETICLS I	COM	210373106	6,703	232,743	SH		SOLE		232,743	0	0
COVETRUS INC	COM	22304C100	36,931	1,285,000	SH		SOLE		1,285,000	0	0
CYTOKINETICS INC	NOTE 4.000%11/1	23282WAA8	17,270	8,000,000	PRN		SOLE		8,000,000	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	7,340	1,649,420	SH		SOLE		1,649,420	0	0
EARGO INC	COM	270087109	40,338	900,000	SH		SOLE		900,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	53,096	582,000	SH		SOLE		582,000	0	0
ENCOMPASS HEALTH CORP	COM	29261A100	41,345	500,000	SH		SOLE		500,000	0	0
EPIZYME INC	COM	29428V104	27,728	2,553,208	SH		SOLE		2,553,208	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	2,196	206,000	SH		SOLE		206,000	0	0
EXACT SCIENCES CORP	COM	30063P105	64,258	485,000	SH		SOLE		485,000	0	0
FIBROGEN INC	COM	31572Q808	11,475	309,387	SH		SOLE		309,387	0	0
FIVE PRIME THERAPEUTICS INC	COM	33830X104	12,275	721,633	SH		SOLE		721,633	0	0
FRESHPET INC	COM	358039105	71,918	506,500	SH		SOLE		506,500	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	11,143	948,327	SH		SOLE		948,327	0	0
GALAPAGOS NV	SPON ADR	36315X101	16,332	165,000	SH		SOLE		165,000	0	0
GALERA THERAPEUTICS INC	COM	36338D108	5,806	567,552	SH		SOLE		567,552	0	0
GAMIDA CELL LTD	SHS	M47364100	17,569	2,094,000	SH		SOLE		2,094,000	0	0
GLOBAL CORD BLOOD CORPORATIO	SHS	G39342103	2,875	775,000	SH		SOLE		775,000	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	14,184	15,573,000	PRN		SOLE		15,573,000	0	0
GUARDANT HEALTH INC	COM	40131M109	25,776	200,000	SH		SOLE		200,000	0	0
GW PHARMACEUTICALS PLC	ADS	36197T103	13,755	119,188	SH		SOLE		119,188	0	0
HCA HEALTHCARE INC	COM	40412C101	74,007	450,000	SH		SOLE		450,000	0	0
HEALTH CATALYST INC	COM	42225T107	34,171	785,000	SH		SOLE		785,000	0	0
HEALTHEQUITY INC	COM	42226A107	5,228	75,000	SH		SOLE		75,000	0	0
HELIX ACQUISITION CORP	COM CL A	G4444C102	1,757	154,500	SH		SOLE		154,500	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	45,719	625,000	SH		SOLE		625,000	0	0
HUMANA INC	COM	444859102	116,927	285,000	SH		SOLE		285,000	0	0
IDEXX LABS INC	COM	45168D104	62,484	125,000	SH		SOLE		125,000	0	0
IMARA INC	COM	45249V107	7,949	360,500	SH		SOLE		360,500	0	0
IMMUNOVANT INC	COM	45258J102	41,155	891,000	SH		SOLE		891,000	0	0
INCYTE CORP	COM	45337C102	26,094	300,000	SH		SOLE		300,000	0	0
INOZYME PHARMA INC	COM	45790W108	17,142	830,546	SH		SOLE		830,546	0	0
INSMED INC	NOTE 1.750% 1/1	457669AA7	6,763	6,000,000	PRN		SOLE		6,000,000	0	0
INSPIRE MED SYS INC	COM	457730109	40,129	213,350	SH		SOLE		213,350	0	0
INSULET CORP	COM	45784P101	81,290	318,000	SH		SOLE		318,000	0	0
INTERSECT ENT INC	COM	46071F103	16,030	700,000	SH		SOLE		700,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	98,172	120,000	SH		SOLE		120,000	0	0
INVITAE CORP	COM	46185L103	77,435	1,852,067	SH		SOLE		1,852,067	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	148,256	625,000	SH		SOLE		625,000	0	0
ITEOS THERAPEUTICS INC	COM	46565G104	5,410	159,957	SH		SOLE		159,957	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	14,442	87,500	SH		SOLE		87,500	0	0
JIYA ACQUISITION CORP	COM CL A	47760M102	2,124	206,200	SH		SOLE		206,200	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	24,783	243,950	SH		SOLE		243,950	0	0
KINNATE BIOPHARMA INC	COM	49705R105	12,916	324,686	SH		SOLE		324,686	0	0
KURA ONCOLOGY INC	COM	50127T109	16,595	508,116	SH		SOLE		508,116	0	0
KYMERA THERAPEUTICS INC	COM	501575104	44,260	713,865	SH		SOLE		713,865	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	8,713	309,418	SH		SOLE		309,418	0	0
LIFESCI ACQUISITION II CORP	COM	53229E103	2,200	206,200	SH		SOLE		206,200	0	0
MACROGENICS INC	COM	556099109	7,075	309,510	SH		SOLE		309,510	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	28,545	256,768	SH		SOLE		256,768	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	54,914	2,063,667	SH		SOLE		2,063,667	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	81,959	373,152	SH		SOLE		373,152	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	26,129	1,496,525	SH		SOLE		1,496,525	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	14,224	515,000	SH		SOLE		515,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	150,964	1,575,000	SH		SOLE		1,575,000	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,390	1,000,000	PRN		SOLE		1,000,000	0	0
NEVRO CORP	COM	64157F103	68,375	395,000	SH		SOLE		395,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	912	500,000	PRN		SOLE		500,000	0	0
NGM BIOPHARMACEUTICALS INC	COM	62921N105	10,921	360,500	SH		SOLE		360,500	0	0
NKARTA INC	COM	65487U108	33,255	541,000	SH		SOLE		541,000	0	0
NOVAVAX INC	COM NEW	670002401	62,803	563,205	SH		SOLE		563,205	0	0
NOVOCURE LTD	ORD SHS	G6674U108	30,282	175,000	SH		SOLE		175,000	0	0
NURIX THERAPEUTICS INC	COM	67080M103	8,458	257,250	SH		SOLE		257,250	0	0
OAK STR HEALTH INC	COM	67181A107	22,935	375,000	SH		SOLE		375,000	0	0
ODONATE THERAPEUTICS INC	COM	676079106	7,252	377,700	SH		SOLE		377,700	0	0
ONESPAWORLD HOLDINGS LIMITED	COM	P73684113	6,997	690,000	SH		SOLE		690,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	61,336	1,025,000	SH		SOLE		1,025,000	0	0
PACIRA BIOSCIENCES INC	NOTE 2.375% 4/0	695127AD2	1,149	1,000,000	PRN		SOLE		1,000,000	0	0
PANACEA ACQUISITION CORP	UNIT 99/99/9999	698102209	5,131	402,088	SH		SOLE		402,088	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	10,521	1,680,614	SH		SOLE		1,680,614	0	0
PENUMBRA INC	COM	70975L107	27,825	159,000	SH		SOLE		159,000	0	0
PHASEBIO PHARMACEUTICALS INC	COM	717224109	4,416	1,314,374	SH		SOLE		1,314,374	0	0
PHREESIA INC	COM	71944F106	46,121	850,000	SH		SOLE		850,000	0	0
POPULATION HEALTH INVS CO IN	UNIT 99/99/9999	G71716123	2,101	201,044	SH		SOLE		201,044	0	0
POSEIDA THERAPEUTICS INC	COM	73730P108	3,179	289,754	SH		SOLE		289,754	0	0
PPD INC	COM	69355F102	17,966	525,000	SH		SOLE		525,000	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	25,784	360,363	SH		SOLE		360,363	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	15,572	643,200	SH		SOLE		643,200	0	0
PROTHENA CORP PLC	SHS	G72800108	13,705	1,141,100	SH		SOLE		1,141,100	0	0
PULMONX CORP	COM	745848101	34,510	500,000	SH		SOLE		500,000	0	0
RADIUS HEALTH INC	NOTE 3.000% 9/0	750469AA6	1,348	1,500,000	PRN		SOLE		1,500,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	17,123	412,000	SH		SOLE		412,000	0	0
RETROPHIN INC	NOTE 2.500% 9/1	761299AB2	3,311	3,250,000	PRN		SOLE		3,250,000	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	14,578	490,339	SH		SOLE		490,339	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	16,600	4,742,891	SH		SOLE		4,742,891	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	21,956	400,370	SH		SOLE		400,370	0	0
ROYALTY PHARMA PLC	SHS CLASS A	G7709Q104	24,024	480,000	SH		SOLE		480,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	56,049	328,750	SH		SOLE		328,750	0	0
SEAGEN INC	COM	81181C104	43,785	250,000	SH		SOLE		250,000	0	0
SHATTUCK LABS INC	COM	82024L103	25,628	489,000	SH		SOLE		489,000	0	0
SHOCKWAVE MED INC	COM	82489T104	22,818	220,000	SH		SOLE		220,000	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	9,095	567,358	SH		SOLE		567,358	0	0
SPERO THERAPEUTICS INC	COM	84833T103	23,947	1,235,000	SH		SOLE		1,235,000	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	39,650	1,631,000	SH		SOLE		1,631,000	0	0
TELEFLEX INCORPORATED	COM	879369106	53,504	130,000	SH		SOLE		130,000	0	0
TG THERAPEUTICS INC	COM	88322Q108	25,438	489,000	SH		SOLE		489,000	0	0
THERAVANCE BIOPHARMA INC	COM	G8807B106	12,052	678,200	SH		SOLE		678,200	0	0
THERAVANCE BIOPHARMA INC	NOTE 3.250%11/0	88339KAA0	1,420	1,500,000	PRN		SOLE		1,500,000	0	0
TRANSLATE BIO INC	COM	89374L104	11,860	643,500	SH		SOLE		643,500	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	27,827	1,021,000	SH		SOLE		1,021,000	0	0
TRILLIUM THERAPEUTICS INC	COM NEW	89620X506	9,098	618,500	SH		SOLE		618,500	0	0
TURMERIC ACQUISITION CORP	UNIT 10/08/2025	G9127T116	2,116	206,000	SH		SOLE		206,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	78,421	566,500	SH		SOLE		566,500	0	0
UNIQURE NV	SHS	N90064101	7,533	208,500	SH		SOLE		208,500	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	142,025	405,000	SH		SOLE		405,000	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	8,074	28,500	SH		SOLE		28,500	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	7,921	515,000	SH		SOLE		515,000	0	0
ZAI LAB LTD	ADR	98887Q104	115,702	854,899	SH		SOLE		854,899	0	0