Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	20,896	1,097,500	SH		SOLE		1,097,500	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	43,925	700,000	SH		SOLE		700,000	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	24,390	1,000,000	SH		SOLE		1,000,000	0	0
ACCOLADE INC	COM	00437E102	36,116	665,000	SH		SOLE		665,000	0	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	5,228	3,788,757	SH		SOLE		3,788,757	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	66,066	3,762,312	SH		SOLE		3,762,312	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	6,582	1,545,000	SH		SOLE		1,545,000	0	0
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	26,559	650,000	SH		SOLE		650,000	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	10,978	1,577,296	SH		SOLE		1,577,296	0	0
AERPIO PHARMACEUTICALS INC	COM	00810B105	225	133,375	SH		SOLE		133,375	0	0
AGILON HEALTH INC	COM	00857U107	283,950	6,999,023	SH		SOLE		6,999,023	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	141,870	2,574,308	SH		SOLE		2,574,308	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	13,115	528,601	SH		SOLE		528,601	0	0
ALIGN TECHNOLOGY INC	COM	016255101	114,715	187,750	SH		SOLE		187,750	0	0
ALLAKOS INC	COM	01671P100	26,098	305,706	SH		SOLE		305,706	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	50,856	300,000	SH		SOLE		300,000	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	18,922	4,320,000	SH		SOLE		4,320,000	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	9,761	1,012,506	SH		SOLE		1,012,506	0	0
ANAPTYSBIO INC	COM	032724106	13,879	535,232	SH		SOLE		535,232	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	9,979	157,900	SH	Call	SOLE		157,900	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	14,581	701,680	SH		SOLE		701,680	0	0
ARDELYX INC	COM	039697107	39,786	5,248,829	SH		SOLE		5,248,829	0	0
ARGENX SE	SPONSORED ADR	04016X101	94,837	315,000	SH		SOLE		315,000	0	0
ARVINAS INC	COM	04335A105	48,210	626,100	SH		SOLE		626,100	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	30,717	233,500	SH		SOLE		233,500	0	0
ATAI LIFE SCIENCES NV	SHS	N0731H103	5,828	315,028	SH		SOLE		315,028	0	0
ATEA PHARMACEUTICALS INC	COM	04683R106	16,994	791,133	SH		SOLE		791,133	0	0
ATHIRA PHARMA INC	COM	04746L104	7,662	748,202	SH		SOLE		748,202	0	0
ATRECA INC	CL A COM	04965G109	3,918	459,830	SH		SOLE		459,830	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	10,184	785,769	SH		SOLE		785,769	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	3,254	309,000	SH		SOLE		309,000	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	68,638	200,000	SH		SOLE		200,000	0	0
BIOGEN INC	COM	09062X103	39,302	113,500	SH		SOLE		113,500	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	21,152	253,500	SH		SOLE		253,500	0	0
BIOMEA FUSION INC	COM	09077A106	18,194	1,165,582	SH		SOLE		1,165,582	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	71,147	808,860	SH		SOLE		808,860	0	0
BOLT BIOTHERAPEUTICS INC	COM	097702104	25,034	1,619,248	SH		SOLE		1,619,248	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	34,208	800,000	SH		SOLE		800,000	0	0
BRIGHT HEALTH GROUP INC	COM	10920V107	40,755	2,375,000	SH		SOLE		2,375,000	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	26,054	1,016,945	SH		SOLE		1,016,945	0	0
CHIASMA INC	COM	16706W102	15,411	3,258,144	SH		SOLE		3,258,144	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	9,636	682,449	SH		SOLE		682,449	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	21,749	920,000	SH		SOLE		920,000	0	0
COMPUGEN LTD	ORD	M25722105	10,242	1,236,988	SH		SOLE		1,236,988	0	0
CONMED CORP	COM	207410101	22,332	162,500	SH		SOLE		162,500	0	0
CONSTELLATION PHARMCETICLS I	COM	210373106	8,355	247,200	SH		SOLE		247,200	0	0
COVETRUS INC	COM	22304C100	39,285	1,455,000	SH		SOLE		1,455,000	0	0
CULLINAN ONCOLOGY INC	COM	230031106	27,705	1,075,912	SH		SOLE		1,075,912	0	0
CYTOKINETICS INC	NOTE 4.000%11/1	23282WAA8	16,570	8,000,000	PRN		SOLE		8,000,000	0	0
DAY ONE BIOPHARMACEUTICALS I	COM	23954D109	8,510	373,739	SH		SOLE		373,739	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	6,604	332,050	SH		SOLE		332,050	0	0
DEXCOM INC	COM	252131107	19,471	45,600	SH		SOLE		45,600	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	16,547	1,679,921	SH		SOLE		1,679,921	0	0
EARGO INC	COM	270087109	57,870	1,450,000	SH		SOLE		1,450,000	0	0
EDAP TMS S A	SPONSORED ADR	268311107	5,395	760,900	SH		SOLE		760,900	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	60,278	582,000	SH		SOLE		582,000	0	0
ENCOMPASS HEALTH CORP	COM	29261A100	39,015	500,000	SH		SOLE		500,000	0	0
EPIZYME INC	COM	29428V104	25,025	3,011,487	SH		SOLE		3,011,487	0	0
ESSA PHARMA INC	COM NEW	29668H708	14,372	503,035	SH		SOLE		503,035	0	0
EUCRATES BIOMEDICAL ACQU COR	UNIT 10/23/2027	G3141W114	2,101	206,000	SH		SOLE		206,000	0	0
EVOLENT HEALTH INC	CL A	30050B101	35,884	1,699,043	SH		SOLE		1,699,043	0	0
EXACT SCIENCES CORP	COM	30063P105	70,857	570,000	SH		SOLE		570,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	6,075	70,000	SH		SOLE		70,000	0	0
FIBROGEN INC	COM	31572Q808	8,327	312,687	SH		SOLE		312,687	0	0
FRESHPET INC	COM	358039105	82,539	506,500	SH		SOLE		506,500	0	0
FS DEVELOPMENT CORP II	COM CL A	30318F100	2,089	209,332	SH		SOLE		209,332	0	0
F-STAR THERAPEUTICS INC	COM	30315R107	9,056	1,054,232	SH		SOLE		1,054,232	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	7,662	948,327	SH		SOLE		948,327	0	0
GALAPAGOS NV	SPON ADR	36315X101	11,367	165,000	SH		SOLE		165,000	0	0
GALERA THERAPEUTICS INC	COM	36338D108	5,586	568,252	SH		SOLE		568,252	0	0
GAMIDA CELL LTD	SHS	M47364100	13,506	2,107,000	SH		SOLE		2,107,000	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	12,585	15,573,000	PRN		SOLE		15,573,000	0	0
GRAPHITE BIO INC	COM	38870X104	66,123	2,151,738	SH		SOLE		2,151,738	0	0
GUARDANT HEALTH INC	COM	40131M109	24,838	200,000	SH		SOLE		200,000	0	0
HCA HEALTHCARE INC	COM	40412C101	93,033	450,000	SH		SOLE		450,000	0	0
HEALTH CATALYST INC	COM	42225T107	43,575	785,000	SH		SOLE		785,000	0	0
HELIX ACQUISITION CORP	COM CL A	G4444C102	1,599	154,500	SH		SOLE		154,500	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	58,525	625,000	SH		SOLE		625,000	0	0
HUMANA INC	COM	444859102	133,923	302,500	SH		SOLE		302,500	0	0
IDEXX LABS INC	COM	45168D104	113,679	180,000	SH		SOLE		180,000	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	93,517	2,394,785	SH		SOLE		2,394,785	0	0
INNOVAGE HLDG CORP	COM	45784A104	19,232	902,500	SH		SOLE		902,500	0	0
INOZYME PHARMA INC	COM	45790W108	14,318	840,272	SH		SOLE		840,272	0	0
INSULET CORP	COM	45784P101	112,206	408,750	SH		SOLE		408,750	0	0
INTERSECT ENT INC	COM	46071F103	20,850	1,220,000	SH		SOLE		1,220,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	110,357	120,000	SH		SOLE		120,000	0	0
INVITAE CORP	COM	46185L103	77,648	2,302,032	SH		SOLE		2,302,032	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	29,725	448,000	SH		SOLE		448,000	0	0
JIYA ACQUISITION CORP	COM CL A	47760M102	2,050	206,200	SH		SOLE		206,200	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	44,071	386,618	SH		SOLE		386,618	0	0
KINNATE BIOPHARMA INC	COM	49705R105	7,719	331,586	SH		SOLE		331,586	0	0
KURA ONCOLOGY INC	COM	50127T109	17,030	816,800	SH		SOLE		816,800	0	0
KYMERA THERAPEUTICS INC	COM	501575104	30,387	626,527	SH		SOLE		626,527	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	12,833	312,618	SH		SOLE		312,618	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	41,790	1,500,000	SH		SOLE		1,500,000	0	0
MACROGENICS INC	COM	556099109	12,243	455,816	SH		SOLE		455,816	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	25,570	262,500	SH		SOLE		262,500	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	14,401	4,542,769	SH		SOLE		4,542,769	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	38,643	2,845,618	SH		SOLE		2,845,618	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	51,542	319,085	SH		SOLE		319,085	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	26,345	1,523,723	SH		SOLE		1,523,723	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	98,780	1,015,000	SH		SOLE		1,015,000	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,347	1,000,000	PRN		SOLE		1,000,000	0	0
NEVRO CORP	COM	64157F103	88,034	531,000	SH		SOLE		531,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	866	500,000	PRN		SOLE		500,000	0	0
NKARTA INC	COM	65487U108	15,780	497,948	SH		SOLE		497,948	0	0
NOVAVAX INC	COM NEW	670002401	96,601	455,000	SH		SOLE		455,000	0	0
NOVOCURE LTD	ORD SHS	G6674U108	38,819	175,000	SH		SOLE		175,000	0	0
NURIX THERAPEUTICS INC	COM	67080M103	8,366	315,350	SH		SOLE		315,350	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	348	134,028	SH		SOLE		134,028	0	0
NUVATION BIO INC	COM CL A	67080N101	2,248	241,485	SH		SOLE		241,485	0	0
OAK STR HEALTH INC	COM	67181A107	21,964	375,000	SH		SOLE		375,000	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	14,629	425,000	SH		SOLE		425,000	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	9,920	1,000,000	SH		SOLE		1,000,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	62,197	1,025,000	SH		SOLE		1,025,000	0	0
PACIRA BIOSCIENCES INC	NOTE 2.375% 4/0	695127AD2	1,094	1,000,000	PRN		SOLE		1,000,000	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	11,285	1,654,714	SH		SOLE		1,654,714	0	0
PENUMBRA INC	COM	70975L107	40,424	147,500	SH		SOLE		147,500	0	0
PHASEBIO PHARMACEUTICALS INC	COM	717224109	6,859	1,843,764	SH		SOLE		1,843,764	0	0
PHREESIA INC	COM	71944F106	58,848	960,000	SH		SOLE		960,000	0	0
POPULATION HEALTH INVS CO IN	UNIT 99/99/9999	G71716123	2,041	201,044	SH		SOLE		201,044	0	0
POSEIDA THERAPEUTICS INC	COM	73730P108	2,903	289,754	SH		SOLE		289,754	0	0
PPD INC	COM	69355F102	31,111	675,000	SH		SOLE		675,000	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	10,947	382,359	SH		SOLE		382,359	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	14,640	596,096	SH		SOLE		596,096	0	0
PROTARA THERAPEUTICS INC	COM STK	74365U107	6,755	693,542	SH		SOLE		693,542	0	0
PROTHENA CORP PLC	SHS	G72800108	48,844	950,091	SH		SOLE		950,091	0	0
PULMONX CORP	COM	745848101	26,141	592,500	SH		SOLE		592,500	0	0
RADIUS HEALTH INC	NOTE 3.000% 9/0	750469AA6	1,393	1,500,000	PRN		SOLE		1,500,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	16,475	450,258	SH		SOLE		450,258	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	10,534	1,129,024	SH		SOLE		1,129,024	0	0
RETROPHIN INC	NOTE 2.500% 9/1	761299AB2	2,765	3,250,000	PRN		SOLE		3,250,000	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	11,871	606,280	SH		SOLE		606,280	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	20,636	4,754,900	SH		SOLE		4,754,900	0	0
ROCKET PHARMACEUTICALS INC	COM	77313F106	17,861	403,270	SH		SOLE		403,270	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	25,557	328,750	SH		SOLE		328,750	0	0
SEAGEN INC	COM	81181C104	39,470	250,000	SH		SOLE		250,000	0	0
SHATTUCK LABS INC	COM	82024L103	9,088	313,499	SH		SOLE		313,499	0	0
SHOCKWAVE MED INC	COM	82489T104	41,741	220,000	SH		SOLE		220,000	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	19,833	1,018,658	SH		SOLE		1,018,658	0	0
SPERO THERAPEUTICS INC	COM	84833T103	13,484	965,928	SH		SOLE		965,928	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	17,992	1,605,001	SH		SOLE		1,605,001	0	0
TELEFLEX INCORPORATED	COM	879369106	52,233	130,000	SH		SOLE		130,000	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	3,468	310,161	SH		SOLE		310,161	0	0
THERAVANCE BIOPHARMA INC	COM	G8807B106	9,983	687,500	SH		SOLE		687,500	0	0
THERAVANCE BIOPHARMA INC	NOTE 3.250%11/0	88339KAA0	1,429	1,500,000	PRN		SOLE		1,500,000	0	0
TRANSLATE BIO INC	COM	89374L104	19,093	693,266	SH		SOLE		693,266	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	21,800	1,494,164	SH		SOLE		1,494,164	0	0
TRILLIUM THERAPEUTICS INC	COM NEW	89620X506	6,096	628,500	SH		SOLE		628,500	0	0
TURMERIC ACQUISITION CORP	UNIT 10/08/2025	G9127T116	2,072	206,000	SH		SOLE		206,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	44,338	465,000	SH		SOLE		465,000	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	96,106	240,000	SH		SOLE		240,000	0	0
VERVE THERAPEUTICS INC	COM	92539P101	58,011	962,826	SH		SOLE		962,826	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	10,234	28,500	SH		SOLE		28,500	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	10,660	572,500	SH		SOLE		572,500	0	0
ZAI LAB LTD	ADR	98887Q104	179,468	1,014,000	SH		SOLE		1,014,000	0	0