Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	26,208	1,432,900	SH		SOLE		1,432,900	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	49,377	753,500	SH		SOLE		753,500	0	0
ACCOLADE INC	COM	00437E102	26,428	1,505,000	SH		SOLE		1,505,000	0	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	1,807	6,329,202	SH		SOLE		6,329,202	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	66,633	3,865,034	SH		SOLE		3,865,034	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	4,732	2,297,194	SH		SOLE		2,297,194	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	4,166	1,811,425	SH		SOLE		1,811,425	0	0
AGILON HEALTH INC	COM	00857U107	193,674	7,640,000	SH		SOLE		7,640,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	77,586	2,665,275	SH		SOLE		2,665,275	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	9,014	635,214	SH		SOLE		635,214	0	0
ALIGN TECHNOLOGY INC	COM	016255101	94,394	216,500	SH		SOLE		216,500	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	54,294	332,500	SH		SOLE		332,500	0	0
AMARIN CORP PLC	SPONS ADR NEW	023111206	14,541	4,419,700	SH		SOLE		4,419,700	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	9,588	1,012,506	SH		SOLE		1,012,506	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	10,799	1,305,825	SH		SOLE		1,305,825	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	12,828	998,307	SH		SOLE		998,307	0	0
ANAPTYSBIO INC	COM	032724106	13,936	563,300	SH		SOLE		563,300	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	1,481	701,680	SH		SOLE		701,680	0	0
ARGENX SE	SPONSORED ADR	04016X101	110,359	350,000	SH		SOLE		350,000	0	0
ARVINAS INC	COM	04335A105	30,796	457,600	SH		SOLE		457,600	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	48,998	417,500	SH		SOLE		417,500	0	0
ATHIRA PHARMA INC	COM	04746L104	7,455	552,252	SH		SOLE		552,252	0	0
ATRECA INC	CL A COM	04965G109	1,466	462,530	SH		SOLE		462,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	22,179	1,008,114	SH		SOLE		1,008,114	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	9,545	771,018	SH		SOLE		771,018	0	0
BAXTER INTL INC	COM	071813109	58,209	750,700	SH		SOLE		750,700	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	3,050	309,000	SH		SOLE		309,000	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	20,393	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	5,198	1,165,582	SH		SOLE		1,165,582	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	60,540	947,715	SH		SOLE		947,715	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	3,315	97,317	SH		SOLE		97,317	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	60,334	1,723,341	SH		SOLE		1,723,341	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	11,458	700,349	SH		SOLE		700,349	0	0
CINCOR PHARMA INC	COM	17240Y109	18,087	1,031,159	SH		SOLE		1,031,159	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	14,761	725,000	SH		SOLE		725,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	7,299	5,328,088	SH		SOLE		5,328,088	0	0
COMPUGEN LTD	ORD	M25722105	4,154	1,289,990	SH		SOLE		1,289,990	0	0
CONMED CORP	COM	207410101	30,081	202,500	SH		SOLE		202,500	0	0
COVETRUS INC	COM	22304C100	28,123	1,675,000	SH		SOLE		1,675,000	0	0
CULLINAN ONCOLOGY INC	COM	230031106	6,832	652,578	SH		SOLE		652,578	0	0
CYTOKINETICS INC	NOTE 4.000%11/1	23282WAA8	29,275	8,000,000	PRN		SOLE		8,000,000	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	5,581	345,597	SH		SOLE		345,597	0	0
DEXCOM INC	COM	252131107	53,206	104,000	SH		SOLE		104,000	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	17,245	1,590,894	SH		SOLE		1,590,894	0	0
EDAP TMS S A	SPONSORED ADR	268311107	5,945	820,000	SH		SOLE		820,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	70,220	596,500	SH		SOLE		596,500	0	0
ENCOMPASS HEALTH CORP	COM	29261A100	35,733	502,500	SH		SOLE		502,500	0	0
EPIZYME INC	COM	29428V104	8,358	7,267,696	SH		SOLE		7,267,696	0	0
EQRX INC	COM	26886C107	4,130	1,000,000	SH		SOLE		1,000,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	3,244	524,944	SH		SOLE		524,944	0	0
EVOLENT HEALTH INC	CL A	30050B101	76,874	2,380,000	SH		SOLE		2,380,000	0	0
EXACT SCIENCES CORP	COM	30063P105	39,854	570,000	SH		SOLE		570,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	4,265	110,000	SH		SOLE		110,000	0	0
FRESHPET INC	COM	358039105	60,814	592,500	SH		SOLE		592,500	0	0
F-STAR THERAPEUTICS INC	COM	30315R107	2,669	751,889	SH		SOLE		751,889	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	10,278	434,590	SH		SOLE		434,590	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	7,369	948,327	SH		SOLE		948,327	0	0
GAMIDA CELL LTD	SHS	M47364100	8,940	2,154,300	SH		SOLE		2,154,300	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	7,692	9,573,000	PRN		SOLE		9,573,000	0	0
GRAPHITE BIO INC	COM	38870X104	9,133	1,790,754	SH		SOLE		1,790,754	0	0
GUARDANT HEALTH INC	COM	40131M109	13,248	200,000	SH		SOLE		200,000	0	0
HCA HEALTHCARE INC	COM	40412C101	93,983	375,000	SH		SOLE		375,000	0	0
HEALTH CATALYST INC	COM	42225T107	23,870	913,500	SH		SOLE		913,500	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	78,487	746,000	SH		SOLE		746,000	0	0
HUMANA INC	COM	444859102	160,404	368,600	SH		SOLE		368,600	0	0
ICOSAVAX INC	COM	45114M109	5,361	761,557	SH		SOLE		761,557	0	0
IDEXX LABS INC	COM	45168D104	119,669	218,750	SH		SOLE		218,750	0	0
IMARA INC	COM	45249V107	1,584	842,402	SH		SOLE		842,402	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	76,306	2,552,034	SH		SOLE		2,552,034	0	0
INOZYME PHARMA INC	COM	45790W108	4,880	1,193,195	SH		SOLE		1,193,195	0	0
INSULET CORP	COM	45784P101	128,320	481,700	SH		SOLE		481,700	0	0
INTERSECT ENT INC	COM	46071F103	15,406	550,000	SH		SOLE		550,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	90,051	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	26,491	3,323,821	SH		SOLE		3,323,821	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	68,657	436,000	SH		SOLE		436,000	0	0
JIYA ACQUISITION CORP	COM CL A	47760M102	2,027	206,200	SH		SOLE		206,200	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	54,842	432,543	SH		SOLE		432,543	0	0
KINNATE BIOPHARMA INC	COM	49705R105	3,875	344,146	SH		SOLE		344,146	0	0
KYMERA THERAPEUTICS INC	COM	501575104	31,989	755,875	SH		SOLE		755,875	0	0
LEAP THERAPEUTICS INC	COM	52187K101	6,292	3,595,447	SH		SOLE		3,595,447	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	14,942	411,184	SH		SOLE		411,184	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	20,220	2,000,000	SH		SOLE		2,000,000	0	0
MACROGENICS INC	COM	556099109	8,217	932,728	SH		SOLE		932,728	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	26,836	273,500	SH		SOLE		273,500	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	6,804	6,074,943	SH		SOLE		6,074,943	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	14,986	3,755,820	SH		SOLE		3,755,820	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	46,021	559,734	SH		SOLE		559,734	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	36,690	1,666,208	SH		SOLE		1,666,208	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,320	1,000,000	PRN		SOLE		1,000,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	103,594	1,105,000	SH		SOLE		1,105,000	0	0
NEVRO CORP	COM	64157F103	52,186	721,500	SH		SOLE		721,500	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	541	500,000	PRN		SOLE		500,000	0	0
NKARTA INC	COM	65487U108	5,803	509,948	SH		SOLE		509,948	0	0
NOVAVAX INC	COM NEW	670002401	33,010	448,200	SH		SOLE		448,200	0	0
NOVOCURE LTD	ORD SHS	G6674U108	14,499	175,000	SH		SOLE		175,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	108	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	17,413	986,000	SH		SOLE		986,000	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	9,820	1,000,000	SH		SOLE		1,000,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	76,320	1,000,000	SH		SOLE		1,000,000	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	5,128	1,726,637	SH		SOLE		1,726,637	0	0
PENUMBRA INC	COM	70975L107	45,426	204,500	SH		SOLE		204,500	0	0
PHASEBIO PHARMACEUTICALS INC	COM	717224109	3,450	2,613,825	SH		SOLE		2,613,825	0	0
PHREESIA INC	COM	71944F106	25,042	950,000	SH		SOLE		950,000	0	0
POSEIDA THERAPEUTICS INC	COM	73730P108	1,298	289,754	SH		SOLE		289,754	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	2,546	368,959	SH		SOLE		368,959	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	23,574	624,307	SH		SOLE		624,307	0	0
PROTHENA CORP PLC	SHS	G72800108	24,265	663,530	SH		SOLE		663,530	0	0
PULMONX CORP	COM	745848101	17,427	702,400	SH		SOLE		702,400	0	0
RADIUS HEALTH INC	NOTE 3.000% 9/0	750469AA6	1,478	1,500,000	PRN		SOLE		1,500,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	18,008	601,667	SH		SOLE		601,667	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	3,361	1,143,185	SH		SOLE		1,143,185	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	14,251	1,237,026	SH		SOLE		1,237,026	0	0
RIGEL PHARMACEUTICALS INC	COM NEW	766559603	14,715	4,921,487	SH		SOLE		4,921,487	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	33,435	428,000	SH		SOLE		428,000	0	0
SEAGEN INC	COM	81181C104	38,966	270,500	SH		SOLE		270,500	0	0
SHATTUCK LABS INC	COM	82024L103	1,336	313,499	SH		SOLE		313,499	0	0
SHOCKWAVE MED INC	COM	82489T104	56,298	271,500	SH		SOLE		271,500	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	37,652	1,174,786	SH		SOLE		1,174,786	0	0
SPERO THERAPEUTICS INC	COM	84833T103	8,621	990,913	SH		SOLE		990,913	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	3,262	1,622,689	SH		SOLE		1,622,689	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	2,784	823,654	SH		SOLE		823,654	0	0
THERAVANCE BIOPHARMA INC	NOTE 3.250%11/0	88339KAA0	1,420	1,500,000	PRN		SOLE		1,500,000	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	5,042	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	24,524	951,650	SH		SOLE		951,650	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	3,396	3,250,000	PRN		SOLE		3,250,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	74,661	1,028,109	SH		SOLE		1,028,109	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	122,393	240,000	SH		SOLE		240,000	0	0
VERVE THERAPEUTICS INC	COM	92539P101	11,502	504,037	SH		SOLE		504,037	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	3,318	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	3,257	814,194	SH		SOLE		814,194	0	0
WARBY PARKER INC	CL A COM	93403J106	35,112	1,038,500	SH		SOLE		1,038,500	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	28,442	69,250	SH		SOLE		69,250	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	25,755	842,498	SH		SOLE		842,498	0	0
XILIO THERAPEUTICS INC	COM	98422T100	8,421	1,191,094	SH		SOLE		1,191,094	0	0
ZAI LAB LTD	ADR	98887Q104	53,035	1,205,900	SH		SOLE		1,205,900	0	0