Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	23,432	1,620,500	SH		SOLE		1,620,500	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	50,959	753,500	SH		SOLE		753,500	0	0
ACCOLADE INC	COM	00437E102	16,280	2,200,000	SH		SOLE		2,200,000	0	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	1,546	6,329,202	SH		SOLE		6,329,202	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	54,823	3,927,149	SH		SOLE		3,927,149	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	4,008	2,357,544	SH		SOLE		2,357,544	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	1,552	3,072,034	SH		SOLE		3,072,034	0	0
AGILON HEALTH INC	COM	00857U107	167,676	7,681,000	SH		SOLE		7,681,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	64,924	2,928,458	SH		SOLE		2,928,458	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	6,421	679,514	SH		SOLE		679,514	0	0
ALIGN TECHNOLOGY INC	COM	016255101	83,900	354,500	SH		SOLE		354,500	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	48,495	332,500	SH		SOLE		332,500	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	10,874	1,012,506	SH		SOLE		1,012,506	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	9,175	1,312,625	SH		SOLE		1,312,625	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	18,761	974,107	SH		SOLE		974,107	0	0
ANAPTYSBIO INC	COM	032724106	11,618	572,300	SH		SOLE		572,300	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	665	701,680	SH		SOLE		701,680	0	0
ARGENX SE	SPONSORED ADR	04016X101	132,608	350,000	SH		SOLE		350,000	0	0
ARVINAS INC	COM	04335A105	11,789	280,100	SH		SOLE		280,100	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	39,554	425,500	SH		SOLE		425,500	0	0
ATRECA INC	CL A COM	04965G109	828	462,530	SH		SOLE		462,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	14,295	1,008,814	SH		SOLE		1,008,814	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	8,192	815,126	SH		SOLE		815,126	0	0
AZENTA INC	COM	114340102	11,680	162,000	SH		SOLE		162,000	0	0
BAXTER INTL INC	COM	071813109	45,064	701,600	SH		SOLE		701,600	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	3,059	309,000	SH		SOLE		309,000	0	0
BEAM THERAPEUTICS INC	COM	07373V105	4,313	111,430	SH		SOLE		111,430	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	15,458	1,461,091	SH		SOLE		1,461,091	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	21,919	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	13,007	1,085,740	SH		SOLE		1,085,740	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	49,458	979,174	SH		SOLE		979,174	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	9,044	335,477	SH		SOLE		335,477	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	46,723	1,767,141	SH		SOLE		1,767,141	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	8,876	507,512	SH		SOLE		507,512	0	0
CINCOR PHARMA INC	COM	17240Y109	19,239	1,021,159	SH		SOLE		1,021,159	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	12,847	725,000	SH		SOLE		725,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	14,119	5,328,088	SH		SOLE		5,328,088	0	0
COMPUGEN LTD	ORD	M25722105	2,386	1,289,990	SH		SOLE		1,289,990	0	0
CONMED CORP	COM	207410101	21,354	223,000	SH		SOLE		223,000	0	0
COVETRUS INC	COM	22304C100	34,835	1,678,800	SH		SOLE		1,678,800	0	0
CYTOKINETICS INC	COM NEW	23282W605	15,716	400,000	SH		SOLE		400,000	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	6,445	460,391	SH		SOLE		460,391	0	0
DEXCOM INC	COM	252131107	35,238	472,800	SH		SOLE		472,800	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	21,170	1,681,458	SH		SOLE		1,681,458	0	0
EDAP TMS S A	SPONSORED ADR	268311107	6,188	910,000	SH		SOLE		910,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	57,244	602,000	SH		SOLE		602,000	0	0
EPIZYME INC	COM	29428V104	11,004	7,485,543	SH		SOLE		7,485,543	0	0
EQRX INC	COM	26886C107	4,690	1,000,000	SH		SOLE		1,000,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	1,654	524,944	SH		SOLE		524,944	0	0
EVOLENT HEALTH INC	CL A	30050B101	84,084	2,738,000	SH		SOLE		2,738,000	0	0
EXACT SCIENCES CORP	COM	30063P105	22,559	572,700	SH		SOLE		572,700	0	0
FATE THERAPEUTICS INC	COM	31189P102	2,726	110,000	SH		SOLE		110,000	0	0
FRESHPET INC	COM	358039105	33,085	637,600	SH		SOLE		637,600	0	0
F-STAR THERAPEUTICS INC	COM	30315R107	4,707	751,889	SH		SOLE		751,889	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	1,884	384,590	SH		SOLE		384,590	0	0
FUSION PHARMACEUTICALS INC	COM	36118A100	2,017	809,854	SH		SOLE		809,854	0	0
GAMIDA CELL LTD	SHS	M47364100	3,850	2,175,000	SH		SOLE		2,175,000	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	7,156	9,573,000	PRN		SOLE		9,573,000	0	0
GUARDANT HEALTH INC	COM	40131M109	8,068	200,000	SH		SOLE		200,000	0	0
HEALTH CATALYST INC	COM	42225T107	13,699	945,400	SH		SOLE		945,400	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	59,501	746,000	SH		SOLE		746,000	0	0
HUMANA INC	COM	444859102	199,565	426,358	SH		SOLE		426,358	0	0
ICOSAVAX INC	COM	45114M109	4,364	761,557	SH		SOLE		761,557	0	0
IDEXX LABS INC	COM	45168D104	78,476	223,750	SH		SOLE		223,750	0	0
IMARA INC	COM	45249V107	1,028	842,402	SH		SOLE		842,402	0	0
IMMATICS N.V	SHS	N44445109	9,825	1,127,970	SH		SOLE		1,127,970	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	99,679	2,671,652	SH		SOLE		2,671,652	0	0
INOZYME PHARMA INC	COM	45790W108	12,593	2,640,056	SH		SOLE		2,640,056	0	0
INSULET CORP	COM	45784P101	109,406	502,000	SH		SOLE		502,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	59,912	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	8,527	3,494,721	SH		SOLE		3,494,721	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	29,168	270,000	SH		SOLE		270,000	0	0
JIYA ACQUISITION CORP	COM CL A	47760M102	2,037	206,200	SH		SOLE		206,200	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	55,904	441,893	SH		SOLE		441,893	0	0
KINNATE BIOPHARMA INC	COM	49705R105	7,798	618,384	SH		SOLE		618,384	0	0
KYMERA THERAPEUTICS INC	COM	501575104	15,277	775,879	SH		SOLE		775,879	0	0
LEAP THERAPEUTICS INC	COM	52187K101	4,201	3,652,947	SH		SOLE		3,652,947	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	19,556	355,567	SH		SOLE		355,567	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	11,120	2,000,000	SH		SOLE		2,000,000	0	0
MACROGENICS INC	COM	556099109	2,816	954,728	SH		SOLE		954,728	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	22,726	317,485	SH		SOLE		317,485	0	0
MEREO BIOPHARMA GROUP PLC	ADS	589492107	6,978	6,230,275	SH		SOLE		6,230,275	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	18,831	4,075,958	SH		SOLE		4,075,958	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	56,723	844,977	SH		SOLE		844,977	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	33,427	1,717,733	SH		SOLE		1,717,733	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,328	1,000,000	PRN		SOLE		1,000,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	109,421	1,122,500	SH		SOLE		1,122,500	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	466	500,000	PRN		SOLE		500,000	0	0
NEVRO CORP	COM	64157F103	33,894	773,300	SH		SOLE		773,300	0	0
NKARTA INC	COM	65487U108	7,593	616,277	SH		SOLE		616,277	0	0
NOVAVAX INC	COM NEW	670002401	24,434	475,100	SH		SOLE		475,100	0	0
NOVOCURE LTD	ORD SHS	G6674U108	12,163	175,000	SH		SOLE		175,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	38	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	18,723	1,231,800	SH		SOLE		1,231,800	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	9,810	1,000,000	SH		SOLE		1,000,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	59,320	1,017,500	SH		SOLE		1,017,500	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	3,347	1,734,037	SH		SOLE		1,734,037	0	0
PENUMBRA INC	COM	70975L107	49,995	401,500	SH		SOLE		401,500	0	0
PHASEBIO PHARMACEUTICALS INC	COM	717224109	1,665	2,774,869	SH		SOLE		2,774,869	0	0
PHREESIA INC	COM	71944F106	32,468	1,298,200	SH		SOLE		1,298,200	0	0
PRELUDE THERAPEUTICS INC	COM	74065P101	1,926	368,959	SH		SOLE		368,959	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	18,194	644,507	SH		SOLE		644,507	0	0
PROTHENA CORP PLC	SHS	G72800108	18,420	678,462	SH		SOLE		678,462	0	0
PULMONX CORP	COM	745848101	10,339	702,400	SH		SOLE		702,400	0	0
RADIUS HEALTH INC	NOTE 3.000% 9/0	750469AA6	1,473	1,500,000	PRN		SOLE		1,500,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	10,356	618,267	SH		SOLE		618,267	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	3,029	1,143,185	SH		SOLE		1,143,185	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	5,824	1,403,298	SH		SOLE		1,403,298	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	32,083	428,000	SH		SOLE		428,000	0	0
SEAGEN INC	COM	81181C104	48,128	272,000	SH		SOLE		272,000	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	25,648	200,000	SH		SOLE		200,000	0	0
SHOCKWAVE MED INC	COM	82489T104	45,976	240,500	SH		SOLE		240,500	0	0
SIERRA ONCOLOGY INC	COM NEW	82640U404	64,601	1,174,786	SH		SOLE		1,174,786	0	0
SPERO THERAPEUTICS INC	COM	84833T103	571	770,710	SH		SOLE		770,710	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	2,823	1,622,689	SH		SOLE		1,622,689	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	1,771	823,654	SH		SOLE		823,654	0	0
THERAVANCE BIOPHARMA INC	NOTE 3.250%11/0	88339KAA0	1,381	1,500,000	PRN		SOLE		1,500,000	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	2,418	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	3,221	3,250,000	PRN		SOLE		3,250,000	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	23,058	951,650	SH		SOLE		951,650	0	0
TURNING POINT THERAPEUTICS I	COM	90041T108	20,452	271,787	SH		SOLE		271,787	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	65,210	1,093,030	SH		SOLE		1,093,030	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	137,910	268,500	SH		SOLE		268,500	0	0
VERVE THERAPEUTICS INC	COM	92539P101	7,702	504,037	SH		SOLE		504,037	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	1,218	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	1,075	814,194	SH		SOLE		814,194	0	0
WARBY PARKER INC	CL A COM	93403J106	14,340	1,273,500	SH		SOLE		1,273,500	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	33,563	111,000	SH		SOLE		111,000	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	34,180	1,123,604	SH		SOLE		1,123,604	0	0
XILIO THERAPEUTICS INC	COM	98422T100	3,980	1,362,878	SH		SOLE		1,362,878	0	0
ZAI LAB LTD	ADR	98887Q104	42,167	1,215,900	SH		SOLE		1,215,900	0	0