Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	30,467	2,032,500	SH		SOLE		2,032,500	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	66,062	845,000	SH		SOLE		845,000	0	0
ACCOLADE INC	COM	00437E102	25,969	2,274,000	SH		SOLE		2,274,000	0	0
ACELRX PHARMACEUTICALS INC	COM	00444T100	1,323	6,329,202	SH		SOLE		6,329,202	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	62,350	3,961,249	SH		SOLE		3,961,249	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	2,534	2,357,544	SH		SOLE		2,357,544	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	1,796	3,413,906	SH		SOLE		3,413,906	0	0
AGILON HEALTH INC	COM	00857U107	181,446	7,747,500	SH		SOLE		7,747,500	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	86,477	3,057,869	SH		SOLE		3,057,869	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	46,648	1,369,973	SH		SOLE		1,369,973	0	0
ALIGN TECHNOLOGY INC	COM	016255101	71,246	344,000	SH		SOLE		344,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	66,553	332,500	SH		SOLE		332,500	0	0
ALTIMMUNE INC	COM NEW	02155H200	2,851	223,255	SH		SOLE		223,255	0	0
ALTIMMUNE INC	COM NEW	02155H200	428	33,500	SH	Call	SOLE		33,500	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	10,571	1,012,506	SH		SOLE		1,012,506	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	9,173	1,325,625	SH		SOLE		1,325,625	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	11,365	403,737	SH		SOLE		403,737	0	0
ANAPTYSBIO INC	COM	032724106	14,709	576,600	SH		SOLE		576,600	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	653	701,680	SH		SOLE		701,680	0	0
ARGENX SE	SPONSORED ADR	04016X101	123,568	350,000	SH		SOLE		350,000	0	0
ARVINAS INC	COM	04335A105	12,462	280,100	SH		SOLE		280,100	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	43,937	425,500	SH		SOLE		425,500	0	0
ATRECA INC	CL A COM	04965G109	726	462,530	SH		SOLE		462,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	18,406	1,015,757	SH		SOLE		1,015,757	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	8,019	1,066,408	SH		SOLE		1,066,408	0	0
AZENTA INC	COM	114340102	14,152	330,200	SH		SOLE		330,200	0	0
BAXTER INTL INC	COM	071813109	40,691	755,500	SH		SOLE		755,500	0	0
BCLS ACQUISITION CORP	COM CL A	G0904B105	3,096	309,000	SH		SOLE		309,000	0	0
BEAM THERAPEUTICS INC	COM	07373V105	5,309	111,430	SH		SOLE		111,430	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	21,578	1,712,507	SH		SOLE		1,712,507	0	0
BIOHAVEN LTD	COM	G1110E107	1,055	167,421	SH		SOLE		167,421	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	22,422	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	7,148	730,846	SH		SOLE		730,846	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	101,352	1,538,195	SH		SOLE		1,538,195	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	11,851	421,604	SH		SOLE		421,604	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	70,626	2,499,148	SH		SOLE		2,499,148	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	9,978	507,512	SH		SOLE		507,512	0	0
CINCOR PHARMA INC	COM	17240Y109	39,576	1,205,856	SH		SOLE		1,205,856	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	11,615	725,000	SH		SOLE		725,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	12,160	5,333,188	SH		SOLE		5,333,188	0	0
COMPUGEN LTD	ORD	M25722105	848	1,289,990	SH		SOLE		1,289,990	0	0
CONMED CORP	COM	207410101	18,680	233,000	SH		SOLE		233,000	0	0
COVETRUS INC	COM	22304C100	35,053	1,678,800	SH		SOLE		1,678,800	0	0
CYTOKINETICS INC	COM NEW	23282W605	21,463	443,000	SH		SOLE		443,000	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	7,698	460,391	SH		SOLE		460,391	0	0
DEXCOM INC	COM	252131107	39,505	490,500	SH		SOLE		490,500	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	17,574	1,683,358	SH		SOLE		1,683,358	0	0
EDAP TMS S A	SPONSORED ADR	268311107	7,508	910,000	SH		SOLE		910,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	52,140	631,000	SH		SOLE		631,000	0	0
EQRX INC	COM	26886C107	4,950	1,000,000	SH		SOLE		1,000,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	955	524,944	SH		SOLE		524,944	0	0
EVOLENT HEALTH INC	CL A	30050B101	117,222	3,262,500	SH		SOLE		3,262,500	0	0
EXACT SCIENCES CORP	COM	30063P105	18,799	578,600	SH		SOLE		578,600	0	0
FATE THERAPEUTICS INC	COM	31189P102	2,465	110,000	SH		SOLE		110,000	0	0
FRESHPET INC	COM	358039105	35,063	700,000	SH		SOLE		700,000	0	0
F-STAR THERAPEUTICS INC	COM	30315R107	3,850	751,889	SH		SOLE		751,889	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	3,111	384,590	SH		SOLE		384,590	0	0
GAMIDA CELL LTD	SHS	M47364100	6,551	4,119,883	SH		SOLE		4,119,883	0	0
GOSSAMER BIO INC	COM	38341P102	19,012	1,586,962	SH		SOLE		1,586,962	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	9,884	9,573,000	PRN		SOLE		9,573,000	0	0
GUARDANT HEALTH INC	COM	40131M109	10,766	200,000	SH		SOLE		200,000	0	0
HEALTH CATALYST INC	COM	42225T107	8,536	880,000	SH		SOLE		880,000	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	44,994	727,000	SH		SOLE		727,000	0	0
HUMANA INC	COM	444859102	206,934	426,500	SH		SOLE		426,500	0	0
ICOSAVAX INC	COM	45114M109	2,468	781,000	SH		SOLE		781,000	0	0
IDEXX LABS INC	COM	45168D104	73,082	224,315	SH		SOLE		224,315	0	0
IMARA INC	COM	45249V107	1,921	842,402	SH		SOLE		842,402	0	0
IMMATICS N.V	SHS	N44445109	16,812	1,681,224	SH		SOLE		1,681,224	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	163,996	3,493,743	SH		SOLE		3,493,743	0	0
INOZYME PHARMA INC	COM	45790W108	7,524	2,807,618	SH		SOLE		2,807,618	0	0
INSULET CORP	COM	45784P101	118,944	518,500	SH		SOLE		518,500	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	55,951	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	8,332	3,386,855	SH		SOLE		3,386,855	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	36,738	293,250	SH		SOLE		293,250	0	0
JIYA ACQUISITION CORP	COM CL A	47760M102	2,056	206,200	SH		SOLE		206,200	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	93,067	413,762	SH		SOLE		413,762	0	0
KINNATE BIOPHARMA INC	COM	49705R105	8,926	746,973	SH		SOLE		746,973	0	0
KYMERA THERAPEUTICS INC	COM	501575104	22,788	1,046,743	SH		SOLE		1,046,743	0	0
LEAP THERAPEUTICS INC	COM	52187K101	3,221	3,659,847	SH		SOLE		3,659,847	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	18,379	450,466	SH		SOLE		450,466	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	13,240	2,000,000	SH		SOLE		2,000,000	0	0
MACROGENICS INC	COM	556099109	4,175	1,206,642	SH		SOLE		1,206,642	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	20,633	317,485	SH		SOLE		317,485	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	5,377	6,244,897	SH		SOLE		6,244,897	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	27,553	4,075,958	SH		SOLE		4,075,958	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	60,536	866,776	SH		SOLE		866,776	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	37,728	1,795,733	SH		SOLE		1,795,733	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	119,221	1,122,500	SH		SOLE		1,122,500	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,413	1,000,000	PRN		SOLE		1,000,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	473	500,000	PRN		SOLE		500,000	0	0
NEVRO CORP	COM	64157F103	36,674	787,000	SH		SOLE		787,000	0	0
NKARTA INC	COM	65487U108	8,110	616,277	SH		SOLE		616,277	0	0
NOVAVAX INC	COM NEW	670002401	10,907	599,300	SH		SOLE		599,300	0	0
NOVOCURE LTD	ORD SHS	G6674U108	13,297	175,000	SH		SOLE		175,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	27	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	17,542	1,445,000	SH		SOLE		1,445,000	0	0
ORION ACQUISITION CORP	UNIT 02/19/2026	68626A207	9,870	1,000,000	SH		SOLE		1,000,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	54,121	1,017,500	SH		SOLE		1,017,500	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	4,456	1,734,037	SH		SOLE		1,734,037	0	0
PENUMBRA INC	COM	70975L107	90,250	476,000	SH		SOLE		476,000	0	0
PHASEBIO PHARMACEUTICALS INC	COM	717224109	479	2,719,074	SH		SOLE		2,719,074	0	0
PHREESIA INC	COM	71944F106	33,188	1,302,500	SH		SOLE		1,302,500	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	38,085	645,407	SH		SOLE		645,407	0	0
PROTHENA CORP PLC	SHS	G72800108	41,135	678,462	SH		SOLE		678,462	0	0
PULMONX CORP	COM	745848101	9,953	597,400	SH		SOLE		597,400	0	0
RELAY THERAPEUTICS INC	COM	75943R102	13,831	618,267	SH		SOLE		618,267	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	3,830	1,143,185	SH		SOLE		1,143,185	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	43,141	1,760,865	SH		SOLE		1,760,865	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	47,532	430,000	SH		SOLE		430,000	0	0
SEAGEN INC	COM	81181C104	37,218	272,000	SH		SOLE		272,000	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	24,222	200,000	SH		SOLE		200,000	0	0
SHOCKWAVE MED INC	COM	82489T104	50,080	180,100	SH		SOLE		180,100	0	0
SPERO THERAPEUTICS INC	COM	84833T103	1,541	770,710	SH		SOLE		770,710	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	2,223	1,622,689	SH		SOLE		1,622,689	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	1,433	823,654	SH		SOLE		823,654	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	2,537	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	3,289	3,250,000	PRN		SOLE		3,250,000	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	23,449	951,650	SH		SOLE		951,650	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	49,195	1,187,992	SH		SOLE		1,187,992	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	136,108	269,500	SH		SOLE		269,500	0	0
VERVE THERAPEUTICS INC	COM	92539P101	19,196	558,837	SH		SOLE		558,837	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	4,295	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	1,530	1,108,570	SH		SOLE		1,108,570	0	0
WARBY PARKER INC	CL A COM	93403J106	17,468	1,309,475	SH		SOLE		1,309,475	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	44,417	180,500	SH		SOLE		180,500	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	41,730	1,155,961	SH		SOLE		1,155,961	0	0
XILIO THERAPEUTICS INC	COM	98422T100	3,966	1,362,878	SH		SOLE		1,362,878	0	0
ZAI LAB LTD	ADR	98887Q104	40,780	1,192,400	SH		SOLE		1,192,400	0	0