Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89BIO INC	COM	282559103	2,505,335	164,500	SH	Call	SOLE		164,500	0	0
ABCAM PLC	ADS	000380204	30,184,050	2,242,500	SH		SOLE		2,242,500	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	62,197,713	860,868	SH		SOLE		860,868	0	0
ACCOLADE INC	COM	00437E102	36,597,100	2,545,000	SH		SOLE		2,545,000	0	0
ACELRX PHARMACEUTICALS INC	COM NEW	00444T209	208,231	316,460	SH		SOLE		316,460	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	32,051,358	3,961,849	SH		SOLE		3,961,849	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	3,038,751	2,787,845	SH		SOLE		2,787,845	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	990,033	3,413,906	SH		SOLE		3,413,906	0	0
AGILON HEALTH INC	COM	00857U107	187,209,375	7,882,500	SH		SOLE		7,882,500	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	61,137,067	2,661,605	SH		SOLE		2,661,605	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	55,639,758	1,454,254	SH		SOLE		1,454,254	0	0
ALIGN TECHNOLOGY INC	COM	016255101	82,649,529	247,350	SH		SOLE		247,350	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	69,110,400	345,000	SH		SOLE		345,000	0	0
ALTIMMUNE INC	COM NEW	02155H200	942,136	223,255	SH		SOLE		223,255	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	11,797,609	1,063,806	SH		SOLE		1,063,806	0	0
AMRYT PHARMA PLC	SPONSORED ADS	03217L106	19,327,613	1,325,625	SH		SOLE		1,325,625	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	42,625,621	1,452,816	SH		SOLE		1,452,816	0	0
ANAPTYSBIO INC	COM	032724106	12,546,816	576,600	SH		SOLE		576,600	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	633,300	780,791	SH		SOLE		780,791	0	0
ARGENX SE	SPONSORED ADR	04016X101	130,403,000	350,000	SH		SOLE		350,000	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	45,622,110	425,500	SH		SOLE		425,500	0	0
ATRECA INC	CL A COM	04965G109	413,284	362,530	SH		SOLE		362,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	9,463,345	1,019,757	SH		SOLE		1,019,757	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	5,255,758	479,540	SH		SOLE		479,540	0	0
AZENTA INC	COM	114340102	19,240,144	431,200	SH		SOLE		431,200	0	0
BEAM THERAPEUTICS INC	COM	07373V105	3,411,987	111,430	SH		SOLE		111,430	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	19,466,269	2,334,085	SH		SOLE		2,334,085	0	0
BIOHAVEN LTD	COM	G1110E107	9,365,610	685,623	SH		SOLE		685,623	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	25,719,980	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	40,226,575	1,297,213	SH		SOLE		1,297,213	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	91,466,830	2,033,048	SH		SOLE		2,033,048	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	15,165,714	421,504	SH		SOLE		421,504	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	61,314,411	2,513,916	SH		SOLE		2,513,916	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	11,748,903	507,512	SH		SOLE		507,512	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	15,593,500	650,000	SH		SOLE		650,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	18,030,087	5,513,788	SH		SOLE		5,513,788	0	0
COMPUGEN LTD	ORD	M25722105	905,573	1,289,990	SH		SOLE		1,289,990	0	0
CONMED CORP	COM	207410101	21,291,300	205,000	SH		SOLE		205,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	15,751,044	447,600	SH		SOLE		447,600	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	2,656,456	460,391	SH		SOLE		460,391	0	0
DEXCOM INC	COM	252131107	56,986,290	490,500	SH		SOLE		490,500	0	0
DISC MEDICINE INC	COM	254604101	6,642,387	313,468	SH		SOLE		313,468	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	17,792,966	1,813,758	SH		SOLE		1,813,758	0	0
EDAP TMS S A	SPONSORED ADR	268311107	11,402,100	1,030,000	SH		SOLE		1,030,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	53,435,307	645,900	SH		SOLE		645,900	0	0
ESSA PHARMA INC	COM NEW	29668H708	1,559,084	524,944	SH		SOLE		524,944	0	0
EVOLENT HEALTH INC	CL A	30050B101	123,423,575	3,803,500	SH		SOLE		3,803,500	0	0
EXACT SCIENCES CORP	COM	30063P105	63,843,115	941,500	SH		SOLE		941,500	0	0
FATE THERAPEUTICS INC	COM	31189P102	3,489,626	612,215	SH		SOLE		612,215	0	0
FRESHPET INC	COM	358039105	43,850,875	662,500	SH		SOLE		662,500	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	2,073,868	727,673	SH		SOLE		727,673	0	0
GAMIDA CELL LTD	SHS	M47364100	1,899,166	2,344,649	SH		SOLE		2,344,649	0	0
GOSSAMER BIO INC	COM	38341P102	1,386,345	1,100,274	SH		SOLE		1,100,274	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	2,641,308	9,573,000	PRN		SOLE		9,573,000	0	0
GUARDANT HEALTH INC	COM	40131M109	4,688,000	200,000	SH		SOLE		200,000	0	0
HEALTH CATALYST INC	COM	42225T107	10,851,933	929,900	SH		SOLE		929,900	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	80,774,514	740,100	SH		SOLE		740,100	0	0
HUMANA INC	COM	444859102	207,048,690	426,500	SH		SOLE		426,500	0	0
ICOSAVAX INC	COM	45114M109	5,014,158	864,510	SH		SOLE		864,510	0	0
IDEXX LABS INC	COM	45168D104	103,766,600	207,500	SH		SOLE		207,500	0	0
IMMATICS N.V	SHS	N44445109	17,346,069	2,513,923	SH		SOLE		2,513,923	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	148,402,169	3,001,662	SH		SOLE		3,001,662	0	0
INOZYME PHARMA INC	COM	45790W108	18,421,377	3,214,900	SH		SOLE		3,214,900	0	0
INSULET CORP	COM	45784P101	171,201,780	536,750	SH		SOLE		536,750	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	76,257,795	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	4,375,924	3,241,425	SH		SOLE		3,241,425	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	38,381,084	309,450	SH		SOLE		309,450	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	89,644,244	493,527	SH		SOLE		493,527	0	0
KINNATE BIOPHARMA INC	COM	49705R105	4,668,581	746,973	SH		SOLE		746,973	0	0
KYMERA THERAPEUTICS INC	COM	501575104	36,396,870	1,228,379	SH		SOLE		1,228,379	0	0
LEAP THERAPEUTICS INC	COM	52187K101	1,582,763	4,655,186	SH		SOLE		4,655,186	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	22,097,538	458,265	SH		SOLE		458,265	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	21,547,000	2,900,000	SH		SOLE		2,900,000	0	0
MACROGENICS INC	COM	556099109	8,052,598	1,123,096	SH		SOLE		1,123,096	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	84,335,793	348,121	SH		SOLE		348,121	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	4,414,518	6,244,897	SH		SOLE		6,244,897	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	16,866,630	4,103,803	SH		SOLE		4,103,803	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	18,282,925	1,167,492	SH		SOLE		1,167,492	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	39,606,404	1,065,261	SH		SOLE		1,065,261	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	43,133,507	1,795,733	SH		SOLE		1,795,733	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,351,500	1,000,000	PRN		SOLE		1,000,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	122,486,322	1,210,100	SH		SOLE		1,210,100	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	470,000	500,000	PRN		SOLE		500,000	0	0
NEVRO CORP	COM	64157F103	38,966,085	1,077,900	SH		SOLE		1,077,900	0	0
NKARTA INC	COM	65487U108	1,396,531	393,389	SH		SOLE		393,389	0	0
NOVAVAX INC	COM NEW	670002401	3,710,322	535,400	SH		SOLE		535,400	0	0
NOVOCURE LTD	ORD SHS	G6674U108	7,517,500	125,000	SH		SOLE		125,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	16,083	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	37,174,500	1,650,000	SH		SOLE		1,650,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	42,140,406	1,032,600	SH		SOLE		1,032,600	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	4,404,454	1,734,037	SH		SOLE		1,734,037	0	0
PENUMBRA INC	COM	70975L107	120,812,115	433,500	SH		SOLE		433,500	0	0
PHREESIA INC	COM	71944F106	42,057,725	1,302,500	SH		SOLE		1,302,500	0	0
PLIANT THERAPEUTICS INC	COM	729139105	13,066,479	491,221	SH		SOLE		491,221	0	0
PROMETHEUS BIOSCIENCES INC	COM	74349U108	110,705,946	1,031,550	SH		SOLE		1,031,550	0	0
PROTHENA CORP PLC	SHS	G72800108	36,520,303	753,462	SH		SOLE		753,462	0	0
PULMONX CORP	COM	745848101	7,293,832	652,400	SH		SOLE		652,400	0	0
RELAY THERAPEUTICS INC	COM	75943R102	11,100,220	673,966	SH		SOLE		673,966	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	6,836,246	1,143,185	SH		SOLE		1,143,185	0	0
REVOLUTION MEDICINES INC	COM	76155X100	15,220,742	702,712	SH		SOLE		702,712	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	28,492,674	1,597,123	SH		SOLE		1,597,123	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	60,989,775	442,500	SH		SOLE		442,500	0	0
SEAGEN INC	COM	81181C104	81,028,494	400,200	SH		SOLE		400,200	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	25,892,000	200,000	SH		SOLE		200,000	0	0
SHOCKWAVE MED INC	COM	82489T104	24,957,133	115,100	SH		SOLE		115,100	0	0
SPERO THERAPEUTICS INC	COM	84833T103	970,823	669,533	SH		SOLE		669,533	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	6,029,156	2,728,125	SH		SOLE		2,728,125	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	1,910,877	823,654	SH		SOLE		823,654	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	3,883,482	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	3,126,481	3,250,000	PRN		SOLE		3,250,000	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	28,711,859	1,276,650	SH		SOLE		1,276,650	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	53,589,680	1,336,401	SH		SOLE		1,336,401	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	127,599,300	270,000	SH		SOLE		270,000	0	0
VERVE THERAPEUTICS INC	COM	92539P101	8,058,430	558,837	SH		SOLE		558,837	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	4,620,469	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	927,388	891,719	SH		SOLE		891,719	0	0
WARBY PARKER INC	CL A COM	93403J106	13,767,000	1,300,000	SH		SOLE		1,300,000	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	69,986,940	202,000	SH		SOLE		202,000	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	42,160,692	1,178,002	SH		SOLE		1,178,002	0	0
XILIO THERAPEUTICS INC	COM	98422T100	4,567,206	1,440,759	SH		SOLE		1,440,759	0	0
ZAI LAB LTD	ADR	98887Q104	35,245,622	1,059,700	SH		SOLE		1,059,700	0	0