Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	58,850,350	2,405,000	SH		SOLE		2,405,000	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	72,313,120	908,000	SH		SOLE		908,000	0	0
ACCOLADE INC	COM	00437E102	37,985,400	2,820,000	SH		SOLE		2,820,000	0	0
ACELRX PHARMACEUTICALS INC	COM NEW	00444T209	351,271	316,460	SH		SOLE		316,460	0	0
ACELYRIN INC	COM	00445A100	2,965,208	141,876	SH		SOLE		141,876	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	41,084,374	3,961,849	SH		SOLE		3,961,849	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	2,578,757	2,787,845	SH		SOLE		2,787,845	0	0
AEGLEA BIOTHERAPEUTICS INC	COM	00773J103	1,537,965	3,413,906	SH		SOLE		3,413,906	0	0
AGILON HEALTH INC	COM	00857U107	143,618,550	8,282,500	SH		SOLE		8,282,500	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	76,072,249	2,686,167	SH		SOLE		2,686,167	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	72,404,704	1,550,754	SH		SOLE		1,550,754	0	0
ALIGN TECHNOLOGY INC	COM	016255101	76,739,880	217,000	SH		SOLE		217,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	65,529,300	345,000	SH		SOLE		345,000	0	0
ALTIMMUNE INC	COM NEW	02155H200	788,090	223,255	SH		SOLE		223,255	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	13,361,403	1,063,806	SH		SOLE		1,063,806	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	33,317,367	1,544,616	SH		SOLE		1,544,616	0	0
ANAPTYSBIO INC	COM	032724106	6,948,897	341,637	SH		SOLE		341,637	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	999,412	780,791	SH		SOLE		780,791	0	0
ARGENX SE	SPONSORED ADR	04016X101	136,405,500	350,000	SH		SOLE		350,000	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	37,975,875	425,500	SH		SOLE		425,500	0	0
ATRECA INC	CL A COM	04965G109	355,279	362,530	SH		SOLE		362,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	12,593,999	1,019,757	SH		SOLE		1,019,757	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	4,641,947	479,540	SH		SOLE		479,540	0	0
AZENTA INC	COM	114340102	21,934,932	469,900	SH		SOLE		469,900	0	0
BEAM THERAPEUTICS INC	COM	07373V105	3,557,960	111,430	SH		SOLE		111,430	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	17,580,239	2,497,193	SH		SOLE		2,497,193	0	0
BIOHAVEN LTD	COM	G1110E107	9,606,846	401,624	SH		SOLE		401,624	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	22,926,860	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	18,369,911	836,898	SH		SOLE		836,898	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	2,844,327	563,233	SH		SOLE		563,233	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	138,197,670	2,186,672	SH		SOLE		2,186,672	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	14,469,075	267,500	SH		SOLE		267,500	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	14,305,397	421,615	SH		SOLE		421,615	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	79,917,390	2,513,916	SH		SOLE		2,513,916	0	0
CHINOOK THERAPEUTICS INC	COM	16961L106	15,225,078	396,280	SH		SOLE		396,280	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	13,968,500	650,000	SH		SOLE		650,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	17,533,846	5,513,788	SH		SOLE		5,513,788	0	0
COMPUGEN LTD	ORD	M25722105	1,470,589	1,289,990	SH		SOLE		1,289,990	0	0
CONMED CORP	COM	207410101	27,857,450	205,000	SH		SOLE		205,000	0	0
CYTOKINETICS INC	COM NEW	23282W605	14,600,712	447,600	SH		SOLE		447,600	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	2,900,463	460,391	SH		SOLE		460,391	0	0
DEXCOM INC	COM	252131107	63,034,155	490,500	SH		SOLE		490,500	0	0
DISC MEDICINE INC	COM	254604101	16,137,979	363,468	SH		SOLE		363,468	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	23,433,753	1,813,758	SH		SOLE		1,813,758	0	0
EDAP TMS S A	SPONSORED ADR	268311107	10,937,686	1,186,300	SH		SOLE		1,186,300	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	60,927,747	645,900	SH		SOLE		645,900	0	0
ESSA PHARMA INC	COM NEW	29668H708	1,790,956	663,317	SH		SOLE		663,317	0	0
EVOLENT HEALTH INC	CL A	30050B101	115,246,050	3,803,500	SH		SOLE		3,803,500	0	0
EXACT SCIENCES CORP	COM	30063P105	88,594,650	943,500	SH		SOLE		943,500	0	0
FATE THERAPEUTICS INC	COM	31189P102	2,914,143	612,215	SH		SOLE		612,215	0	0
FRESHPET INC	COM	358039105	43,599,125	662,500	SH		SOLE		662,500	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	2,401,321	727,673	SH		SOLE		727,673	0	0
GAMIDA CELL LTD	SHS	M47364100	1,379,994	715,023	SH		SOLE		715,023	0	0
GOSSAMER BIO INC	COM	38341P102	1,320,329	1,100,274	SH		SOLE		1,100,274	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	2,888,997	9,573,000	PRN		SOLE		9,573,000	0	0
GUARDANT HEALTH INC	COM	40131M109	7,160,000	200,000	SH		SOLE		200,000	0	0
HEALTH CATALYST INC	COM	42225T107	11,623,750	929,900	SH		SOLE		929,900	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	50,910,750	495,000	SH		SOLE		495,000	0	0
HUMANA INC	COM	444859102	210,151,100	470,000	SH		SOLE		470,000	0	0
ICOSAVAX INC	COM	45114M109	8,623,301	868,409	SH		SOLE		868,409	0	0
IDEXX LABS INC	COM	45168D104	97,683,735	194,500	SH		SOLE		194,500	0	0
IMMATICS N.V	SHS	N44445109	29,267,102	2,536,144	SH		SOLE		2,536,144	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	181,583,464	3,028,410	SH		SOLE		3,028,410	0	0
IMMUNOGEN INC	COM	45253H101	2,125,139	112,620	SH		SOLE		112,620	0	0
INOZYME PHARMA INC	COM	45790W108	19,094,428	3,428,084	SH		SOLE		3,428,084	0	0
INSULET CORP	COM	45784P101	161,182,060	559,000	SH		SOLE		559,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	102,069,090	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	1,865,059	1,650,495	SH		SOLE		1,650,495	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	32,281,824	309,450	SH		SOLE		309,450	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	107,021,330	493,527	SH		SOLE		493,527	0	0
KINNATE BIOPHARMA INC	COM	49705R105	2,263,328	746,973	SH		SOLE		746,973	0	0
KRYSTAL BIOTECH INC	COM	501147102	4,097,377	34,901	SH		SOLE		34,901	0	0
KYMERA THERAPEUTICS INC	COM	501575104	34,198,797	1,487,551	SH		SOLE		1,487,551	0	0
LEAP THERAPEUTICS INC	COM NEW	52187K200	3,363,238	1,074,517	SH		SOLE		1,074,517	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	31,634,033	458,265	SH		SOLE		458,265	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	26,477,000	2,900,000	SH		SOLE		2,900,000	0	0
MACROGENICS INC	COM	556099109	6,008,564	1,123,096	SH		SOLE		1,123,096	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	46,019,358	199,218	SH		SOLE		199,218	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	9,295,956	7,042,391	SH		SOLE		7,042,391	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	11,196,308	3,403,133	SH		SOLE		3,403,133	0	0
MERUS N V	COM	N5749R100	12,599,721	478,531	SH		SOLE		478,531	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	19,905,739	1,167,492	SH		SOLE		1,167,492	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	40,525,106	1,121,647	SH		SOLE		1,121,647	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	47,102,363	1,820,733	SH		SOLE		1,820,733	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,276,050	1,000,000	PRN		SOLE		1,000,000	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	120,656,850	1,279,500	SH		SOLE		1,279,500	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	462,430	500,000	PRN		SOLE		500,000	0	0
NEVRO CORP	COM	64157F103	30,793,788	1,211,400	SH		SOLE		1,211,400	0	0
NKARTA INC	COM	65487U108	726,140	331,571	SH		SOLE		331,571	0	0
NOVAVAX INC	COM NEW	670002401	3,987,681	536,700	SH		SOLE		536,700	0	0
NOVOCURE LTD	ORD SHS	G6674U108	5,187,500	125,000	SH		SOLE		125,000	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	22,167	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	31,012,500	1,654,000	SH		SOLE		1,654,000	0	0
PACIRA BIOSCIENCES INC	COM	695127100	41,472,450	1,035,000	SH		SOLE		1,035,000	0	0
PARATEK PHARMACEUTICALS INC	COM	699374302	3,832,222	1,734,037	SH		SOLE		1,734,037	0	0
PENUMBRA INC	COM	70975L107	125,925,960	366,000	SH		SOLE		366,000	0	0
PHREESIA INC	COM	71944F106	40,468,050	1,305,000	SH		SOLE		1,305,000	0	0
PLIANT THERAPEUTICS INC	COM	729139105	8,900,925	491,221	SH		SOLE		491,221	0	0
PROTHENA CORP PLC	SHS	G72800108	51,446,385	753,462	SH		SOLE		753,462	0	0
PULMONX CORP	COM	745848101	8,552,964	652,400	SH		SOLE		652,400	0	0
RELAY THERAPEUTICS INC	COM	75943R102	8,465,013	673,966	SH		SOLE		673,966	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	7,499,294	1,143,185	SH		SOLE		1,143,185	0	0
REVOLUTION MEDICINES INC	COM	76155X100	18,797,546	702,712	SH		SOLE		702,712	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	26,336,558	1,597,123	SH		SOLE		1,597,123	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	48,671,000	425,000	SH		SOLE		425,000	0	0
SEAGEN INC	COM	81181C104	77,022,492	400,200	SH		SOLE		400,200	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	26,546,000	200,000	SH		SOLE		200,000	0	0
SHOCKWAVE MED INC	COM	82489T104	32,850,691	115,100	SH		SOLE		115,100	0	0
SPERO THERAPEUTICS INC	COM	84833T103	970,823	669,533	SH		SOLE		669,533	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	5,865,469	2,728,125	SH		SOLE		2,728,125	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	680,992	536,214	SH		SOLE		536,214	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	4,080,280	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	23,465,779	1,527,720	SH		SOLE		1,527,720	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	2,856,545	3,250,000	PRN		SOLE		3,250,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	63,856,329	1,384,269	SH		SOLE		1,384,269	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	110,547,200	230,000	SH		SOLE		230,000	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	4,436,405	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	1,159,235	891,719	SH		SOLE		891,719	0	0
WARBY PARKER INC	CL A COM	93403J106	15,489,250	1,325,000	SH		SOLE		1,325,000	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	77,258,940	202,000	SH		SOLE		202,000	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	45,353,077	1,178,002	SH		SOLE		1,178,002	0	0
XILIO THERAPEUTICS INC	COM	98422T100	3,774,789	1,440,759	SH		SOLE		1,440,759	0	0
ZAI LAB LTD	ADR	98887Q104	33,897,790	1,222,423	SH		SOLE		1,222,423	0	0