Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABCAM PLC	ADS	000380204	28,853,250	1,275,000	SH		SOLE		1,275,000	0	0
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	63,841,480	908,000	SH		SOLE		908,000	0	0
ACCOLADE INC	COM	00437E102	30,819,540	2,913,000	SH		SOLE		2,913,000	0	0
ACELRX PHARMACEUTICALS INC	COM NEW	00444T209	183,547	316,460	SH		SOLE		316,460	0	0
ACELYRIN INC	COM	00445A100	1,442,879	141,876	SH		SOLE		141,876	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	27,129,076	3,960,449	SH		SOLE		3,960,449	0	0
ACUMEN PHARMACEUTICALS INC	COM	00509G209	11,672,203	2,812,579	SH		SOLE		2,812,579	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	2,174,519	2,787,845	SH		SOLE		2,787,845	0	0
AEGLEA BIOTHERAPEUTICS INC	COM NEW	00773J202	1,672,811	136,556	SH		SOLE		136,556	0	0
AGILON HEALTH INC	COM	00857U107	147,274,800	8,292,500	SH		SOLE		8,292,500	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	67,074,010	2,710,061	SH		SOLE		2,710,061	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	71,780,607	1,419,150	SH		SOLE		1,419,150	0	0
ALIGN TECHNOLOGY INC	COM	016255101	66,254,440	217,000	SH		SOLE		217,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	49,499,450	279,500	SH		SOLE		279,500	0	0
AMGEN INC	COM	031162100	18,275,680	68,000	SH		SOLE		68,000	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	12,935,881	1,063,806	SH		SOLE		1,063,806	0	0
AMYLYX PHARMACEUTICALS INC	COM	03237H101	28,289,243	1,545,016	SH		SOLE		1,545,016	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	2,013,934	808,809	SH		SOLE		808,809	0	0
ARGENX SE	SPONSORED ADR	04016X101	127,332,170	259,000	SH		SOLE		259,000	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	39,843,820	425,500	SH		SOLE		425,500	0	0
ATRECA INC	CL A COM	04965G109	94,620	362,530	SH		SOLE		362,530	0	0
AURA BIOSCIENCES INC	COM	05153U107	6,484,377	722,896	SH		SOLE		722,896	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	3,726,026	479,540	SH		SOLE		479,540	0	0
AZENTA INC	COM	114340102	23,965,725	477,500	SH		SOLE		477,500	0	0
BEAM THERAPEUTICS INC	COM	07373V105	2,679,892	111,430	SH		SOLE		111,430	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	18,062,680	2,551,226	SH		SOLE		2,551,226	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	23,402,960	264,500	SH		SOLE		264,500	0	0
BIOMEA FUSION INC	COM	09077A106	2,492,583	181,147	SH		SOLE		181,147	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	134,855,465	2,685,294	SH		SOLE		2,685,294	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	61,248,000	1,160,000	SH		SOLE		1,160,000	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	13,762,780	500,101	SH		SOLE		500,101	0	0
CEREVEL THERAPEUTICS HLDNG I	COM	15678U128	55,210,602	2,529,116	SH		SOLE		2,529,116	0	0
CERVOMED INC	COM	15713L109	369,752	80,033	SH		SOLE		80,033	0	0
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	12,560,700	562,000	SH		SOLE		562,000	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	10,862,162	5,513,788	SH		SOLE		5,513,788	0	0
COMPUGEN LTD	ORD	M25722105	1,199,691	1,289,990	SH		SOLE		1,289,990	0	0
CYTOKINETICS INC	COM NEW	23282W605	3,955,064	134,252	SH		SOLE		134,252	0	0
DESIGN THERAPEUTICS INC	COM	25056L103	1,086,523	460,391	SH		SOLE		460,391	0	0
DEXCOM INC	COM	252131107	54,487,200	584,000	SH		SOLE		584,000	0	0
DISC MEDICINE INC	COM	254604101	17,075,727	363,468	SH		SOLE		363,468	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	26,789,206	1,813,758	SH		SOLE		1,813,758	0	0
EDAP TMS S A	SPONSORED ADR	268311107	9,547,200	1,360,000	SH		SOLE		1,360,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	44,844,944	647,300	SH		SOLE		647,300	0	0
ESSA PHARMA INC	COM NEW	29668H708	2,091,945	677,005	SH		SOLE		677,005	0	0
EVOLENT HEALTH INC	CL A	30050B101	105,243,950	3,865,000	SH		SOLE		3,865,000	0	0
EXACT SCIENCES CORP	COM	30063P105	69,465,015	1,018,250	SH		SOLE		1,018,250	0	0
FATE THERAPEUTICS INC	COM	31189P102	1,297,896	612,215	SH		SOLE		612,215	0	0
FRESHPET INC	COM	358039105	43,645,500	662,500	SH		SOLE		662,500	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	3,230,868	727,673	SH		SOLE		727,673	0	0
GAMIDA CELL LTD	SHS	M47364100	53,575	52,015	SH		SOLE		52,015	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	3,707,987	9,573,000	PRN		SOLE		9,573,000	0	0
GOSSAMER BIO INC	COM	38341P102	2,720,724	3,266,960	SH		SOLE		3,266,960	0	0
HEALTH CATALYST INC	COM	42225T107	3,111,900	307,500	SH		SOLE		307,500	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	29,558,795	255,500	SH		SOLE		255,500	0	0
HUMANA INC	COM	444859102	212,365,980	436,500	SH		SOLE		436,500	0	0
ICOSAVAX INC	COM	45114M109	6,730,170	868,409	SH		SOLE		868,409	0	0
IDEXX LABS INC	COM	45168D104	85,049,015	194,500	SH		SOLE		194,500	0	0
IMMATICS N.V	SHS	N44445109	21,717,896	1,875,466	SH		SOLE		1,875,466	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	152,778,549	2,943,710	SH		SOLE		2,943,710	0	0
IMMUNOGEN INC	COM	45253H101	12,051,123	759,365	SH		SOLE		759,365	0	0
IMMUNOVANT INC	COM	45258J102	24,736,366	644,344	SH		SOLE		644,344	0	0
INOZYME PHARMA INC	COM	45790W108	15,460,931	3,681,174	SH		SOLE		3,681,174	0	0
INSPIRE MED SYS INC	COM	457730109	8,830,580	44,500	SH		SOLE		44,500	0	0
INSULET CORP	COM	45784P101	60,606,200	380,000	SH		SOLE		380,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	87,248,565	298,500	SH		SOLE		298,500	0	0
INVITAE CORP	COM	46185L103	354,441	585,659	SH		SOLE		585,659	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	33,061,695	350,750	SH		SOLE		350,750	0	0
KARUNA THERAPEUTICS INC	COM	48576A100	85,463,666	505,433	SH		SOLE		505,433	0	0
KINNATE BIOPHARMA INC	COM	49705R105	568,135	405,811	SH		SOLE		405,811	0	0
KRYSTAL BIOTECH INC	COM	501147102	10,504,960	90,560	SH		SOLE		90,560	0	0
KYMERA THERAPEUTICS INC	COM	501575104	20,910,479	1,504,351	SH		SOLE		1,504,351	0	0
LEAP THERAPEUTICS INC	COM NEW	52187K200	1,482,833	1,074,517	SH		SOLE		1,074,517	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	30,781,660	458,265	SH		SOLE		458,265	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	25,212,900	3,670,000	SH		SOLE		3,670,000	0	0
MACROGENICS INC	COM	556099109	5,493,189	1,178,796	SH		SOLE		1,178,796	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	28,677,729	196,369	SH		SOLE		196,369	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	9,902,660	7,676,481	SH		SOLE		7,676,481	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	4,321,979	3,403,133	SH		SOLE		3,403,133	0	0
MERUS N V	COM	N5749R100	19,770,132	838,428	SH		SOLE		838,428	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	11,102,849	1,167,492	SH		SOLE		1,167,492	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	49,275,377	1,131,207	SH		SOLE		1,131,207	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	57,535,163	1,820,733	SH		SOLE		1,820,733	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	139,050,000	1,236,000	SH		SOLE		1,236,000	0	0
NEUROCRINE BIOSCIENCES INC	NOTE 2.250% 5/1	64125CAD1	1,497,950	1,000,000	PRN		SOLE		1,000,000	0	0
NEVRO CORP	COM	64157F103	23,286,952	1,211,600	SH		SOLE		1,211,600	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	472,128	500,000	PRN		SOLE		500,000	0	0
NKARTA INC	COM	65487U108	460,884	331,571	SH		SOLE		331,571	0	0
NOVAVAX INC	COM NEW	670002401	4,689,348	647,700	SH		SOLE		647,700	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	13,403	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	24,728,375	1,676,500	SH		SOLE		1,676,500	0	0
PACIRA BIOSCIENCES INC	COM	695127100	32,382,740	1,055,500	SH		SOLE		1,055,500	0	0
PENUMBRA INC	COM	70975L107	121,862,163	503,750	SH		SOLE		503,750	0	0
PHREESIA INC	COM	71944F106	33,182,984	1,776,391	SH		SOLE		1,776,391	0	0
PLIANT THERAPEUTICS INC	COM	729139105	8,517,772	491,221	SH		SOLE		491,221	0	0
PROTHENA CORP PLC	SHS	G72800108	29,639,879	614,298	SH		SOLE		614,298	0	0
PULMONX CORP	COM	745848101	6,739,292	652,400	SH		SOLE		652,400	0	0
RELAY THERAPEUTICS INC	COM	75943R102	5,668,054	673,966	SH		SOLE		673,966	0	0
RENEO PHARMACEUTICALS INC	COM	75974E103	8,705,354	1,143,185	SH		SOLE		1,143,185	0	0
REVOLUTION MEDICINES INC	COM	76155X100	20,072,207	725,152	SH		SOLE		725,152	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	36,614,045	1,597,123	SH		SOLE		1,597,123	0	0
SAGIMET BIOSCIENCES INC	COM SER A	786700104	6,497,524	738,355	SH		SOLE		738,355	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	47,518,240	392,000	SH		SOLE		392,000	0	0
SEAGEN INC	COM	81181C104	84,902,430	400,200	SH		SOLE		400,200	0	0
SELECT SECTOR SPDR TR	SBI HEALTHCARE	81369Y209	25,748,000	200,000	SH		SOLE		200,000	0	0
SHOCKWAVE MED INC	COM	82489T104	29,367,250	147,500	SH		SOLE		147,500	0	0
SPERO THERAPEUTICS INC	COM	84833T103	69,421	57,373	SH		SOLE		57,373	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	6,165,563	2,728,125	SH		SOLE		2,728,125	0	0
TEMPEST THERAPEUTICS INC	COM	87978U108	163,384	536,214	SH		SOLE		536,214	0	0
THESEUS PHARMACEUTICALS INC	COM	88369M101	1,176,415	437,329	SH		SOLE		437,329	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	16,161,213	1,807,742	SH		SOLE		1,807,742	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	2,677,483	3,250,000	PRN		SOLE		3,250,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	52,635,122	1,476,441	SH		SOLE		1,476,441	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	115,963,700	230,000	SH		SOLE		230,000	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	2,543,854	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	900,636	891,719	SH		SOLE		891,719	0	0
WARBY PARKER INC	CL A COM	93403J106	20,727,000	1,575,000	SH		SOLE		1,575,000	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	75,792,420	202,000	SH		SOLE		202,000	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	40,240,548	1,178,002	SH		SOLE		1,178,002	0	0
XILIO THERAPEUTICS INC	COM	98422T100	3,040,001	1,440,759	SH		SOLE		1,440,759	0	0
ZAI LAB LTD	ADR	98887Q104	30,072,029	1,237,023	SH		SOLE		1,237,023	0	0