Rock Springs Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACADIA HEALTHCARE COMPANY IN	COM	00404A109	79,528,350	1,177,500	SH		SOLE		1,177,500	0	0
ACCOLADE INC	COM	00437E102	8,198,200	2,290,000	SH		SOLE		2,290,000	0	0
ACLARIS THERAPEUTICS INC	COM	00461U105	3,028,845	2,753,495	SH		SOLE		2,753,495	0	0
ACUMEN PHARMACEUTICALS INC	COM	00509G209	5,566,143	2,300,059	SH		SOLE		2,300,059	0	0
ADAPTIMMUNE THERAPEUTICS PLC	SPONDS ADR	00653A107	2,364,589	2,425,468	SH		SOLE		2,425,468	0	0
AGILON HEALTH INC	COM	00857U107	58,206,000	8,900,000	SH		SOLE		8,900,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	45,028,534	1,044,261	SH		SOLE		1,044,261	0	0
AKERO THERAPEUTICS INC	COM	00973Y108	25,202,163	1,074,261	SH		SOLE		1,074,261	0	0
ALIGN TECHNOLOGY INC	COM	016255101	30,782,325	127,500	SH		SOLE		127,500	0	0
ALLAKOS INC	COM	01671P100	1,200,409	1,200,409	SH		SOLE		1,200,409	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	60,750,000	250,000	SH		SOLE		250,000	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	12,088,314	1,218,580	SH		SOLE		1,218,580	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	5,397,252	140,700	SH		SOLE		140,700	0	0
APPLIED THERAPEUTICS INC	COM	03828A101	7,261,869	1,555,004	SH		SOLE		1,555,004	0	0
ARGENX SE	SPONSORED ADR	04016X101	98,586,670	229,250	SH		SOLE		229,250	0	0
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	39,550,200	290,000	SH		SOLE		290,000	0	0
AURINIA PHARMACEUTICALS INC	COM	05156V102	6,736,315	1,179,740	SH		SOLE		1,179,740	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	3,594,798	1,032,988	SH		SOLE		1,032,988	0	0
AZENTA INC	COM	114340102	36,623,520	696,000	SH		SOLE		696,000	0	0
BEAM THERAPEUTICS INC	COM	07373V105	5,855,696	249,923	SH		SOLE		249,923	0	0
BIOCRYST PHARMACEUTICALS INC	COM	09058V103	22,367,014	3,619,258	SH		SOLE		3,619,258	0	0
BIOHAVEN LTD	COM	G1110E107	4,427,538	127,558	SH		SOLE		127,558	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	12,431,830	151,000	SH		SOLE		151,000	0	0
BIOMEA FUSION INC	COM	09077A106	815,162	181,147	SH		SOLE		181,147	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	265,183,744	2,460,417	SH		SOLE		2,460,417	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	6,143,460	57,000	SH	Call	SOLE		57,000	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	62,955,675	817,500	SH		SOLE		817,500	0	0
CELLDEX THERAPEUTICS INC NEW	COM NEW	15117B202	51,776,768	1,398,994	SH		SOLE		1,398,994	0	0
CHARLES RIV LABS INTL INC	COM	159864107	12,446,445	60,250	SH		SOLE		60,250	0	0
COMPASS THERAPEUTICS INC	COM	20454B104	5,513,788	5,513,788	SH		SOLE		5,513,788	0	0
COMPUGEN LTD	ORD	M25722105	1,663,183	989,990	SH		SOLE		989,990	0	0
CRINETICS PHARMACEUTICALS IN	COM	22663K107	12,962,226	289,400	SH		SOLE		289,400	0	0
CULLINAN THERAPEUTICS INC	COM	230031106	11,481,415	658,338	SH		SOLE		658,338	0	0
DEXCOM INC	COM	252131107	56,690,000	500,000	SH		SOLE		500,000	0	0
DYNAVAX TECHNOLOGIES CORP	COM NEW	268158201	14,516,314	1,292,637	SH		SOLE		1,292,637	0	0
DYNE THERAPEUTICS INC	COM	26818M108	16,269,678	461,028	SH		SOLE		461,028	0	0
EDAP TMS S A	SPONSORED ADR	268311107	8,024,000	1,475,000	SH		SOLE		1,475,000	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	50,803,500	550,000	SH		SOLE		550,000	0	0
ELI LILLY & CO	COM	532457108	110,003,670	121,500	SH		SOLE		121,500	0	0
ENLIVEN THERAPEUTICS INC	COM	29337E102	10,015,704	428,571	SH		SOLE		428,571	0	0
ESSA PHARMA INC	COM NEW	29668H708	3,561,046	677,005	SH		SOLE		677,005	0	0
EVOLENT HEALTH INC	CL A	30050B101	77,961,800	4,077,500	SH		SOLE		4,077,500	0	0
EXACT SCIENCES CORP	COM	30063P105	45,693,375	1,081,500	SH		SOLE		1,081,500	0	0
FRESHPET INC	COM	358039105	62,107,200	480,000	SH		SOLE		480,000	0	0
FULCRUM THERAPEUTICS INC	COM	359616109	4,511,573	727,673	SH		SOLE		727,673	0	0
GOSSAMER BIO INC	NOTE 5.000% 6/0	38341PAA0	4,735,945	9,573,000	PRN		SOLE		9,573,000	0	0
GOSSAMER BIO INC	COM	38341P102	2,943,204	3,266,960	SH		SOLE		3,266,960	0	0
HUMANA INC	COM	444859102	55,078,999	147,408	SH		SOLE		147,408	0	0
IDEXX LABS INC	COM	45168D104	58,220,400	119,500	SH		SOLE		119,500	0	0
IMMUNOCORE HLDGS PLC	ADS	45258D105	14,200,927	419,030	SH		SOLE		419,030	0	0
IMMUNOVANT INC	COM	45258J102	31,301,266	1,185,654	SH		SOLE		1,185,654	0	0
INOZYME PHARMA INC	COM	45790W108	16,494,748	3,698,374	SH		SOLE		3,698,374	0	0
INSMED INC	COM PAR $.01	457669307	54,159,852	808,356	SH		SOLE		808,356	0	0
INSPIRE MED SYS INC	COM	457730109	17,397,900	130,000	SH		SOLE		130,000	0	0
INSULET CORP	COM	45784P101	39,351,000	195,000	SH		SOLE		195,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	132,787,725	298,500	SH		SOLE		298,500	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	42,786,900	397,500	SH		SOLE		397,500	0	0
JASPER THERAPEUTICS INC	COM NEW	471871202	9,178,405	404,335	SH		SOLE		404,335	0	0
JOHNSON & JOHNSON	COM	478160104	24,847,200	170,000	SH		SOLE		170,000	0	0
KORRO BIO INC	COM	500946108	1,209,803	35,719	SH		SOLE		35,719	0	0
KRYSTAL BIOTECH INC	COM	501147102	19,386,691	105,569	SH		SOLE		105,569	0	0
KYMERA THERAPEUTICS INC	COM	501575104	34,744,594	1,163,973	SH		SOLE		1,163,973	0	0
KYVERNA THERAPEUTICS INC	COM	501976104	1,342,223	178,963	SH		SOLE		178,963	0	0
LEAP THERAPEUTICS INC	COM NEW	52187K200	2,482,430	1,266,546	SH		SOLE		1,266,546	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	22,401,262	505,786	SH		SOLE		505,786	0	0
LIFESTANCE HEALTH GROUP INC	COM	53228F101	23,704,007	4,827,700	SH		SOLE		4,827,700	0	0
MACROGENICS INC	COM	556099109	4,478,000	1,053,647	SH		SOLE		1,053,647	0	0
MADRIGAL PHARMACEUTICALS INC	COM	558868105	68,779,000	245,499	SH		SOLE		245,499	0	0
MEREO BIOPHARMA GROUP PLC	SPON ADS	589492107	33,420,571	9,283,492	SH		SOLE		9,283,492	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	6,124,032	3,046,782	SH		SOLE		3,046,782	0	0
MERUS N V	COM	N5749R100	59,233,489	1,001,073	SH		SOLE		1,001,073	0	0
MINERALYS THERAPEUTICS INC	COM	603170101	4,433,504	378,932	SH		SOLE		378,932	0	0
MIRUM PHARMACEUTICALS INC	COM	604749101	60,585,979	1,772,038	SH		SOLE		1,772,038	0	0
NEUMORA THERAPEUTICS INC.	COM	640979100	7,470,869	760,007	SH		SOLE		760,007	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	129,409,800	940,000	SH		SOLE		940,000	0	0
NEVRO CORP	NOTE 2.750% 4/0	64157FAC7	483,261	500,000	PRN		SOLE		500,000	0	0
NEVRO CORP	COM	64157F103	11,632,230	1,381,500	SH		SOLE		1,381,500	0	0
NOVAVAX INC	COM NEW	670002401	8,545,500	675,000	SH		SOLE		675,000	0	0
NOVO-NORDISK A S	ADR	670100205	21,054,150	147,500	SH		SOLE		147,500	0	0
NUVALENT INC	COM	670703107	19,419,326	255,989	SH		SOLE		255,989	0	0
NUVATION BIO INC	*W EXP 07/07/202	67080N119	21,444	134,028	SH		SOLE		134,028	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	12,740,000	500,000	SH		SOLE		500,000	0	0
OSCAR HEALTH INC	CL A	687793109	19,798,730	1,251,500	SH		SOLE		1,251,500	0	0
PACIRA BIOSCIENCES INC	COM	695127100	22,458,850	785,000	SH		SOLE		785,000	0	0
PENUMBRA INC	COM	70975L107	47,692,050	265,000	SH		SOLE		265,000	0	0
PERSPECTIVE THERAPEUTICS INC	COM NEW	46489V302	3,999,924	401,196	SH		SOLE		401,196	0	0
PHARVARIS N V	COM	N69605108	14,230,303	756,931	SH		SOLE		756,931	0	0
PHREESIA INC	COM	71944F106	51,251,000	2,417,500	SH		SOLE		2,417,500	0	0
PLIANT THERAPEUTICS INC	COM	729139105	4,138,707	384,996	SH		SOLE		384,996	0	0
PROTHENA CORP PLC	SHS	G72800108	12,900,991	625,048	SH		SOLE		625,048	0	0
PULMONX CORP	COM	745848101	4,136,216	652,400	SH		SOLE		652,400	0	0
REVOLUTION MEDICINES INC	COM	76155X100	36,605,398	943,195	SH		SOLE		943,195	0	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	52,577,043	1,280,493	SH		SOLE		1,280,493	0	0
SAGIMET BIOSCIENCES INC	COM SER A	786700104	2,694,303	787,808	SH		SOLE		787,808	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	44,872,000	284,000	SH		SOLE		284,000	0	0
SPRINGWORKS THERAPEUTICS INC	COM	85205L107	7,528,538	199,855	SH		SOLE		199,855	0	0
SPRUCE BIOSCIENCES INC	COM	85209E109	1,350,744	2,609,125	SH		SOLE		2,609,125	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	2,576,112	65,600	SH	Call	SOLE		65,600	0	0
STRUCTURE THERAPEUTICS INC	SPONSORED ADS	86366E106	39,264,581	999,862	SH		SOLE		999,862	0	0
TALPHERA INC	COM NEW	00444T209	281,649	316,460	SH		SOLE		316,460	0	0
TRAVERE THERAPEUTICS INC	COM	89422G107	36,844,218	4,482,265	SH		SOLE		4,482,265	0	0
TRAVERE THERAPEUTICS INC	NOTE 2.500% 9/1	761299AB2	2,887,651	3,250,000	PRN		SOLE		3,250,000	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	79,079,359	1,924,072	SH		SOLE		1,924,072	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	140,046,500	275,000	SH		SOLE		275,000	0	0
VERA THERAPEUTICS INC	CL A	92337R101	13,791,527	381,192	SH		SOLE		381,192	0	0
VIGIL NEUROSCIENCE INC	COM	92673K108	1,887,832	471,958	SH		SOLE		471,958	0	0
VINCERX PHARMA INC	COM NEW	92731L106	722,292	891,719	SH		SOLE		891,719	0	0
WARBY PARKER INC	CL A COM	93403J106	33,404,800	2,080,000	SH		SOLE		2,080,000	0	0
WEST PHARMACEUTICAL SVSC INC	COM	955306105	47,926,245	145,500	SH		SOLE		145,500	0	0
XENON PHARMACEUTICALS INC	COM	98420N105	49,629,474	1,272,877	SH		SOLE		1,272,877	0	0
XILIO THERAPEUTICS INC	COM	98422T100	2,845,588	3,003,259	SH		SOLE		3,003,259	0	0
ZAI LAB LTD	ADR	98887Q104	22,492,139	1,297,873	SH		SOLE		1,297,873	0	0