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Exhibit 21.1
SUBSIDIARIES
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| Subsidiary |
| Jurisdiction of Incorporation |
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|
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1 |
| Sage Securities Corporation |
| Massachusetts |
2 |
| Sage (Bermuda) Ltd. |
| Bermuda |
3 |
| Sage Therapeutics Limited |
| England and Wales |
4 |
| Sage Therapeutics GmbH |
| Switzerland |
5 |
| Sage Therapeutics GmbH |
| Germany |
6 |
| Sage Therapeutics, Inc. |
| Canada |