Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on FormS-8 of our report dated March 28, 2014, except for Note 13, as to which the date is July 2, 2014, relating to the financial statements of Sage Therapeutics, Inc., which appears in Sage Therapeutics, Inc.’s Amendment No. 3 to the Registration Statement on Form S-1 (No. 333-196849).
/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
July 17, 2014
