The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Argos Therapeutics Inc. | Common | 040221103 | 39,428 | 13,142,784 | SH | DFND | 1 | 0 | 13,142,784 | 0 | |
| Argos Therapeutics Inc. | Common | 040221103 | 15,362 | 5,120,604 | SH | Call | DFND | 1 | 0 | 5,120,604 | 0 |
| Proteon Therapeutics Inc. | Common | 74371L109 | 3,169 | 1,667,907 | SH | DFND | 1 | 0 | 1,667,907 | 0 | |
| Protagonist Therapeutics, Inc. | Common | 74366E102 | 20,431 | 982,270 | SH | DFND | 1 | 0 | 982,270 | 0 | |
| Jounce Therapeutics, Inc. | Common | 481116101 | 8,441 | 662,063 | SH | DFND | 1 | 0 | 662,063 | 0 | |
| Allena Pharmaceuticals | Common | 018119107 | 10,435 | 1,037,267 | SH | DFND | 1 | 0 | 1,037,267 | 0 | |